PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23687615-6	2013	Additionally, these actin filaments are rapidly reorganized during BTB restructuring to accommodate the transit of preleptotene spermatocytes across the barrier at stage VIII of the epithelial cycle.	btb	67-70	cytochrome c oxidase subunit 8A	Homo sapiens	170-174
24307990-2	2013	Here, we report a biophysical characterization of the POZ/BTB of KCTD6, a protein that is involved in the turnover of the muscle small ankyrin-1 isoform 5 and, in combination with KCTD11, in the ubiquitination and degradation of HDAC1.	btb	58-61	potassium channel tetramerization domain containing 6	Homo sapiens	65-70
24307990-2	2013	Here, we report a biophysical characterization of the POZ/BTB of KCTD6, a protein that is involved in the turnover of the muscle small ankyrin-1 isoform 5 and, in combination with KCTD11, in the ubiquitination and degradation of HDAC1.	btb	58-61	potassium channel tetramerization domain containing 11	Homo sapiens	180-186
24307990-2	2013	Here, we report a biophysical characterization of the POZ/BTB of KCTD6, a protein that is involved in the turnover of the muscle small ankyrin-1 isoform 5 and, in combination with KCTD11, in the ubiquitination and degradation of HDAC1.	btb	58-61	histone deacetylase 1	Homo sapiens	229-234
23573258-6	2013	Both the BTB and BACK domains contribute to the Cul3 interaction surface, and an extended model of the dimeric CRL3 complex places the two E2 binding sites in a suprafacial arrangement with respect to the presumed substrate-binding sites.	btb	9-12	cullin 3	Homo sapiens	48-52
23573258-6	2013	Both the BTB and BACK domains contribute to the Cul3 interaction surface, and an extended model of the dimeric CRL3 complex places the two E2 binding sites in a suprafacial arrangement with respect to the presumed substrate-binding sites.	btb	9-12	interleukin 31 receptor A	Homo sapiens	111-115
23931822-7	2013	The disease is caused by mutation in the GAN gene encoding for gigaxonin, a member of BTB-Kelch.	btb	86-89	gigaxonin	Homo sapiens	41-44
23738048-6	2013	On the other hand, entry and accumulation of Nrf2 protein in the nucleus, while exportting the transcriptional repressor BTB and CNC homology 1 (Bach1) from nucleus to cytoplasm, were also confirmed by western blot and immunofluorescence assay.	btb	121-124	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
22712528-4	2012	We observed that miR-155 upregulation is directly linked to the attenuation of expression of BTB and CNC homology 1 (Bach1) and SH2-containing inositol 5"-phosphatase (SHIP1).	btb	93-96	microRNA 155	Mus musculus	17-24
22709582-1	2012	RhoBTB (BTB stands for broad-complex, tramtrack, bric a brac) proteins are tumor suppressors involved in the formation of cullin 3 (Cul3)-dependent ubiquitin ligase complexes.	btb	3-6	cullin 3	Homo sapiens	122-130
22709582-1	2012	RhoBTB (BTB stands for broad-complex, tramtrack, bric a brac) proteins are tumor suppressors involved in the formation of cullin 3 (Cul3)-dependent ubiquitin ligase complexes.	btb	3-6	cullin 3	Homo sapiens	132-136
22761335-4	2012	The conserved BTB protein interaction domain in NAC1 is the minimal region for actin binding.	btb	14-17	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	Mus musculus	48-52
22531886-1	2012	Our previous studies have demonstrated that both the RhoA/Rho kinase and the protein kinase C (PKC) signaling pathways are involved in the low-dose endothelial monocyte-activating polypeptide-II (EMAP-II)-induced blood-tumor barrier (BTB) opening.	btb	234-237	ras homolog family member A	Rattus norvegicus	53-57
22531886-1	2012	Our previous studies have demonstrated that both the RhoA/Rho kinase and the protein kinase C (PKC) signaling pathways are involved in the low-dose endothelial monocyte-activating polypeptide-II (EMAP-II)-induced blood-tumor barrier (BTB) opening.	btb	234-237	protein kinase C, alpha	Rattus norvegicus	95-98
22531886-2	2012	In the present study, an in vitro BTB model was used to investigate which isoforms of PKC were involved in this process as well as the interactions between the RhoA/Rho kinase and the PKC signaling pathways.	btb	34-37	protein kinase C, alpha	Rattus norvegicus	86-89
22531886-8	2012	The effects of EMAP-II on BTB permeability and TJ proteins expression were completely blocked by inhibition of both RhoA and PKC-zeta, whereas inhibition of both RhoA and PKC-alpha/beta had an effect similar to that of inhibition of RhoA alone.	btb	26-29	ras homolog family member A	Rattus norvegicus	116-120
22581438-3	2012	This study was performed to determine the role of signaling cascades involving reactive oxygen species (ROS)/RhoA/PI3K/PKB in increasing the permeability of the BTB induced by NS1619.	btb	161-164	ras homolog family member A	Rattus norvegicus	109-113
22581438-4	2012	Using an in vitro BTB model and selective inhibitors of signaling pathways, we investigated whether ROS/RhoA/PI3K/PKB pathway plays a key role in the process of the increase in BTB permeability induced by NS1619.	btb	177-180	ras homolog family member A	Rattus norvegicus	104-108
22581438-7	2012	The present study demonstrates that the activation of signaling cascades involving ROS/RhoA/PI3K/PKB in rat brain microvascular endothelial cells was required for the increase in BTB permeability induced by NS1619.	btb	179-182	ras homolog family member A	Rattus norvegicus	87-91
21647708-0	2012	Role of RhoA/ROCK signaling in endothelial-monocyte-activating polypeptide II opening of the blood-tumor barrier: role of RhoA/ROCK signaling in EMAP II opening of the BTB.	btb	168-171	ras homolog family member A	Rattus norvegicus	122-126
21647708-6	2012	The present study demonstrates that the activation of RhoA/ROCK signaling in RBMECs was required for the increase of BTB permeability and these effects are related with the ability for RhoA/ROCK to mediate TJ disassembly and stress fiber formation by phosphorylating cofilin and MLC.	btb	117-120	ras homolog family member A	Rattus norvegicus	54-58
21743489-5	2012	We further demonstrated that knockdown of NAC1 by RNA interference or inactivation of NAC1 by inducing the expression of a NAC1 deletion mutant that contains only the BTB/POZ domain significantly inhibited the cisplatin-induced autophagy, resulting in increased cisplatin cytotoxicity.	btb	167-170	nucleus accumbens associated 1	Homo sapiens	42-46
21647708-6	2012	The present study demonstrates that the activation of RhoA/ROCK signaling in RBMECs was required for the increase of BTB permeability and these effects are related with the ability for RhoA/ROCK to mediate TJ disassembly and stress fiber formation by phosphorylating cofilin and MLC.	btb	117-120	ras homolog family member A	Rattus norvegicus	185-189
21743489-5	2012	We further demonstrated that knockdown of NAC1 by RNA interference or inactivation of NAC1 by inducing the expression of a NAC1 deletion mutant that contains only the BTB/POZ domain significantly inhibited the cisplatin-induced autophagy, resulting in increased cisplatin cytotoxicity.	btb	167-170	nucleus accumbens associated 1	Homo sapiens	86-90
21743489-5	2012	We further demonstrated that knockdown of NAC1 by RNA interference or inactivation of NAC1 by inducing the expression of a NAC1 deletion mutant that contains only the BTB/POZ domain significantly inhibited the cisplatin-induced autophagy, resulting in increased cisplatin cytotoxicity.	btb	167-170	nucleus accumbens associated 1	Homo sapiens	86-90
21334421-4	2011	In addition, MPG also significantly inhibited the increase of BTB permeability and malonaldehyde (MDA) level induced by NS1619.	btb	62-65	N-methylpurine-DNA glycosylase	Rattus norvegicus	13-16
22289179-4	2012	Bach1 depletion resulted in disordered mitotic chromosome alignment, which was rescued by Bach1 mutants lacking the BTB or DNA binding domains, suggesting its transcription-independent mechanism.	btb	116-119	BTB domain and CNC homolog 1	Homo sapiens	0-5
22289179-4	2012	Bach1 depletion resulted in disordered mitotic chromosome alignment, which was rescued by Bach1 mutants lacking the BTB or DNA binding domains, suggesting its transcription-independent mechanism.	btb	116-119	BTB domain and CNC homolog 1	Homo sapiens	90-95
21331626-5	2011	This led to the conclusion that the MS-induced BTB permeability increase may be related to the accelerated formation of caveolin-1 protein, and could be mediated by ROS.	btb	47-50	caveolin 1	Rattus norvegicus	120-130
22219362-1	2012	Cullin-3 (Cul3) functions as a scaffolding protein in the Bric-a-brac, Tramtrack, Broad-complex (BTB)-Cul3-Rbx1 ubiquitin E3 ligase complex.	btb	97-100	cullin 3	Homo sapiens	0-8
22219362-1	2012	Cullin-3 (Cul3) functions as a scaffolding protein in the Bric-a-brac, Tramtrack, Broad-complex (BTB)-Cul3-Rbx1 ubiquitin E3 ligase complex.	btb	97-100	cullin 3	Homo sapiens	10-14
22219362-1	2012	Cullin-3 (Cul3) functions as a scaffolding protein in the Bric-a-brac, Tramtrack, Broad-complex (BTB)-Cul3-Rbx1 ubiquitin E3 ligase complex.	btb	97-100	cullin 3	Homo sapiens	102-106
22629405-3	2012	Here, we determine the extent of BTB permeability induced by the natural and synthetic peptide B1R agonists, LysdesArg(9)BK (LDBK) and SarLys[dPhe(8)]desArg(9)BK (NG29), in syngeneic F98 glioma-implanted Fischer rats.	btb	33-36	bradykinin receptor B1	Rattus norvegicus	95-98
22629405-9	2012	Our results documented a novel GPCR-signaling mechanism for promoting transient BTB disruption, involving activation of B1R and ensuing production of COX metabolites.	btb	80-83	bradykinin receptor B1	Rattus norvegicus	120-123
22629405-10	2012	They also underlined the potential value of synthetic biostable B1R agonists as selective BTB modulators for local delivery of different sized-therapeutics at (peri)tumoral sites.	btb	90-93	bradykinin receptor B1	Rattus norvegicus	64-67
21821048-5	2011	Here, we have shown by size-exclusion chromatography, chemical cross-linking, and nondenaturing PAGE that four additional BTB domains of the ttk group-Batman, Mod(mdg4), Pipsqueak, and Tramtrack-can form multimers, like GAF.	btb	122-125	tramtrack	Drosophila melanogaster	141-144
21821048-5	2011	Here, we have shown by size-exclusion chromatography, chemical cross-linking, and nondenaturing PAGE that four additional BTB domains of the ttk group-Batman, Mod(mdg4), Pipsqueak, and Tramtrack-can form multimers, like GAF.	btb	122-125	lola like	Drosophila melanogaster	151-157
21821048-5	2011	Here, we have shown by size-exclusion chromatography, chemical cross-linking, and nondenaturing PAGE that four additional BTB domains of the ttk group-Batman, Mod(mdg4), Pipsqueak, and Tramtrack-can form multimers, like GAF.	btb	122-125	modifier of mdg4	Drosophila melanogaster	159-167
21821048-5	2011	Here, we have shown by size-exclusion chromatography, chemical cross-linking, and nondenaturing PAGE that four additional BTB domains of the ttk group-Batman, Mod(mdg4), Pipsqueak, and Tramtrack-can form multimers, like GAF.	btb	122-125	tramtrack	Drosophila melanogaster	185-194
21821048-5	2011	Here, we have shown by size-exclusion chromatography, chemical cross-linking, and nondenaturing PAGE that four additional BTB domains of the ttk group-Batman, Mod(mdg4), Pipsqueak, and Tramtrack-can form multimers, like GAF.	btb	122-125	Trithorax-like	Drosophila melanogaster	220-223
21193965-2	2011	The second goal was to determine possible cellular mechanisms by which VEGF increases permeability of the BTB.	btb	106-109	vascular endothelial growth factor A	Rattus norvegicus	71-75
21193965-3	2011	In the rat C6 glioma model, the permeability of the BTB was significantly increased after VEGF injection at dose of 0.05 ng/g and reached its peak at 45 min.	btb	52-55	vascular endothelial growth factor A	Rattus norvegicus	90-94
21193965-6	2011	The time peak of expression level of caveolin-1 and caveolin-2 was identical with the peak time of permeability of the BTB and the density of pinocytotic vesicles.	btb	119-122	caveolin 1	Rattus norvegicus	37-47
21193965-6	2011	The time peak of expression level of caveolin-1 and caveolin-2 was identical with the peak time of permeability of the BTB and the density of pinocytotic vesicles.	btb	119-122	caveolin 2	Rattus norvegicus	52-62
21193965-7	2011	All of these results strongly indicated that VEGF increased permeability of the BTB caused by enhancement of the density of pinocytotic vesicles, and the molecular mechanism might be associated with upregulated expression of caveolin-1 and caveolin-2.	btb	80-83	vascular endothelial growth factor A	Rattus norvegicus	45-49
21193965-7	2011	All of these results strongly indicated that VEGF increased permeability of the BTB caused by enhancement of the density of pinocytotic vesicles, and the molecular mechanism might be associated with upregulated expression of caveolin-1 and caveolin-2.	btb	80-83	caveolin 1	Rattus norvegicus	225-235
21193965-7	2011	All of these results strongly indicated that VEGF increased permeability of the BTB caused by enhancement of the density of pinocytotic vesicles, and the molecular mechanism might be associated with upregulated expression of caveolin-1 and caveolin-2.	btb	80-83	caveolin 2	Rattus norvegicus	240-250
21472142-6	2011	Indeed, the novel genes (KCASH2(KCTD21) and KCASH3(KCTD6)) share with REN(KCTD11) a number of features, such as a BTB domain required for the formation of a Cullin3 ubiquitin ligase complex and HDAC1 ubiquitination and degradation capability, suppressing the acetylation-dependent Hh/Gli signaling.	btb	114-117	potassium channel tetramerization domain containing 21	Homo sapiens	25-31
20683758-7	2011	Significantly down-regulated expression levels of ZO-1, occludin and claudin-5 might be one of the molecular mechanisms of combining LFU and PA enhancing the permeability of BTB.	btb	174-177	tight junction protein 1	Rattus norvegicus	50-54
20683758-7	2011	Significantly down-regulated expression levels of ZO-1, occludin and claudin-5 might be one of the molecular mechanisms of combining LFU and PA enhancing the permeability of BTB.	btb	174-177	occludin	Rattus norvegicus	56-64
20683758-7	2011	Significantly down-regulated expression levels of ZO-1, occludin and claudin-5 might be one of the molecular mechanisms of combining LFU and PA enhancing the permeability of BTB.	btb	174-177	claudin 5	Rattus norvegicus	69-78
21472142-6	2011	Indeed, the novel genes (KCASH2(KCTD21) and KCASH3(KCTD6)) share with REN(KCTD11) a number of features, such as a BTB domain required for the formation of a Cullin3 ubiquitin ligase complex and HDAC1 ubiquitination and degradation capability, suppressing the acetylation-dependent Hh/Gli signaling.	btb	114-117	potassium channel tetramerization domain containing 21	Homo sapiens	32-38
21472142-6	2011	Indeed, the novel genes (KCASH2(KCTD21) and KCASH3(KCTD6)) share with REN(KCTD11) a number of features, such as a BTB domain required for the formation of a Cullin3 ubiquitin ligase complex and HDAC1 ubiquitination and degradation capability, suppressing the acetylation-dependent Hh/Gli signaling.	btb	114-117	potassium channel tetramerization domain containing 6	Homo sapiens	44-50
21472142-6	2011	Indeed, the novel genes (KCASH2(KCTD21) and KCASH3(KCTD6)) share with REN(KCTD11) a number of features, such as a BTB domain required for the formation of a Cullin3 ubiquitin ligase complex and HDAC1 ubiquitination and degradation capability, suppressing the acetylation-dependent Hh/Gli signaling.	btb	114-117	potassium channel tetramerization domain containing 6	Homo sapiens	51-56
21472142-6	2011	Indeed, the novel genes (KCASH2(KCTD21) and KCASH3(KCTD6)) share with REN(KCTD11) a number of features, such as a BTB domain required for the formation of a Cullin3 ubiquitin ligase complex and HDAC1 ubiquitination and degradation capability, suppressing the acetylation-dependent Hh/Gli signaling.	btb	114-117	potassium channel tetramerization domain containing 11	Homo sapiens	70-80
21472142-6	2011	Indeed, the novel genes (KCASH2(KCTD21) and KCASH3(KCTD6)) share with REN(KCTD11) a number of features, such as a BTB domain required for the formation of a Cullin3 ubiquitin ligase complex and HDAC1 ubiquitination and degradation capability, suppressing the acetylation-dependent Hh/Gli signaling.	btb	114-117	cullin 3	Homo sapiens	157-164
21472142-6	2011	Indeed, the novel genes (KCASH2(KCTD21) and KCASH3(KCTD6)) share with REN(KCTD11) a number of features, such as a BTB domain required for the formation of a Cullin3 ubiquitin ligase complex and HDAC1 ubiquitination and degradation capability, suppressing the acetylation-dependent Hh/Gli signaling.	btb	114-117	histone deacetylase 1	Homo sapiens	194-199
21472142-6	2011	Indeed, the novel genes (KCASH2(KCTD21) and KCASH3(KCTD6)) share with REN(KCTD11) a number of features, such as a BTB domain required for the formation of a Cullin3 ubiquitin ligase complex and HDAC1 ubiquitination and degradation capability, suppressing the acetylation-dependent Hh/Gli signaling.	btb	114-117	GLI family zinc finger 1	Homo sapiens	284-287
20728510-4	2010	The levels of occludin, claudin-5 and F-actin protein in the tumor tissues were down-regulated by papaverine via immunohistochemistry, immunofluorescence assays and Western blot, corresponding to the time-dependent change of the BTB permeability.	btb	229-232	occludin	Rattus norvegicus	14-22
21904435-3	2011	Trl-GAF binds to GAGA sites through its C2H2 zinc finger domain and has an N-terminal BTB/POZ domain.	btb	86-89	Trithorax-like	Drosophila melanogaster	0-3
21904435-3	2011	Trl-GAF binds to GAGA sites through its C2H2 zinc finger domain and has an N-terminal BTB/POZ domain.	btb	86-89	fibroblast growth factor 9	Mus musculus	4-7
20829328-9	2010	BTB permeability was associated with vascular remodeling and correlated with overexpression of the pericyte protein desmin.	btb	0-3	desmin	Mus musculus	116-122
20728510-7	2010	The results demonstrate that the reversible openning of BTB mediated by papaverine may be associated with the functional combination between PKA and HSP70.	btb	56-59	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	141-144
20852968-7	2011	The mRNA and protein expression levels of claudin-5, occludin, and ZO-1 decreased significantly at 3 h, restored gradually and nearly recovered after 12 h. The correlation between the increase of BTB permeability and the reduction of tight junction-related proteins suggests that LFU combined with microbubbles may be involved in the opening of the BTB by the tight junction-related proteins.	btb	196-199	claudin 5	Homo sapiens	42-51
20852968-7	2011	The mRNA and protein expression levels of claudin-5, occludin, and ZO-1 decreased significantly at 3 h, restored gradually and nearly recovered after 12 h. The correlation between the increase of BTB permeability and the reduction of tight junction-related proteins suggests that LFU combined with microbubbles may be involved in the opening of the BTB by the tight junction-related proteins.	btb	196-199	occludin	Homo sapiens	53-61
20852968-7	2011	The mRNA and protein expression levels of claudin-5, occludin, and ZO-1 decreased significantly at 3 h, restored gradually and nearly recovered after 12 h. The correlation between the increase of BTB permeability and the reduction of tight junction-related proteins suggests that LFU combined with microbubbles may be involved in the opening of the BTB by the tight junction-related proteins.	btb	196-199	tight junction protein 1	Homo sapiens	67-71
20852968-7	2011	The mRNA and protein expression levels of claudin-5, occludin, and ZO-1 decreased significantly at 3 h, restored gradually and nearly recovered after 12 h. The correlation between the increase of BTB permeability and the reduction of tight junction-related proteins suggests that LFU combined with microbubbles may be involved in the opening of the BTB by the tight junction-related proteins.	btb	349-352	claudin 5	Homo sapiens	42-51
20852968-7	2011	The mRNA and protein expression levels of claudin-5, occludin, and ZO-1 decreased significantly at 3 h, restored gradually and nearly recovered after 12 h. The correlation between the increase of BTB permeability and the reduction of tight junction-related proteins suggests that LFU combined with microbubbles may be involved in the opening of the BTB by the tight junction-related proteins.	btb	349-352	tight junction protein 1	Homo sapiens	67-71
20369389-8	2010	RhoA activation is important for BK-induced increase in BTB permeability and appears to involve the ability for RhoA to mediate occludin disassembly and stress fiber formation.	btb	56-59	ras homolog family member A	Rattus norvegicus	0-4
20728510-7	2010	The results demonstrate that the reversible openning of BTB mediated by papaverine may be associated with the functional combination between PKA and HSP70.	btb	56-59	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	149-154
20728510-9	2010	HSP70 is likely responsible for the BTB closing, which helping the repairment of injured TJ protein and the rebuilding of the BTB.	btb	36-39	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	0-5
20728510-9	2010	HSP70 is likely responsible for the BTB closing, which helping the repairment of injured TJ protein and the rebuilding of the BTB.	btb	126-129	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	0-5
20504342-11	2010	Co-expression studies with a haemagglutinin (HA) tagged wild type Mayven cDNA and EGFP tagged mutant cDNAs suggested a homomeric interaction mediated by the BTB/POZ domain.	btb	157-160	kelch-like family member 2	Rattus norvegicus	66-72
20146088-8	2010	This led to the conclusion that the BK-mediated BTB permeability increase resulting from augmentation of the quantity of pinocytotic vesicles (transcellular pathway) is associated with the significantly up-regulated expression of caveolin-1 and caveolin-2.	btb	48-51	caveolin 1	Rattus norvegicus	230-240
20146088-8	2010	This led to the conclusion that the BK-mediated BTB permeability increase resulting from augmentation of the quantity of pinocytotic vesicles (transcellular pathway) is associated with the significantly up-regulated expression of caveolin-1 and caveolin-2.	btb	48-51	caveolin 2	Rattus norvegicus	245-255
20179090-10	2010	CONCLUSIONS: This finding suggests that heme controls a macrophage iron recycling regulon involving Btb and Cnc Homology 1 and Nuclear Factor Erythroid 2-like to assure the coordinated degradation of heme by heme oxygenase 1, iron storage and detoxification by ferritin, and iron export by iron export protein ferroportin.	btb	100-103	heme oxygenase 1	Mus musculus	208-224
20493880-0	2010	Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1.	btb	33-36	zinc finger and BTB domain containing 32	Homo sapiens	82-86
20493880-0	2010	Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1.	btb	33-36	zinc finger and BTB domain containing 17	Homo sapiens	91-95
20493880-6	2010	The Miz1 BTB domain resembles a typical swapped BTB dimer, although it has a shorter N-terminus that is not able to form the interchain sheet.	btb	9-12	zinc finger and BTB domain containing 17	Homo sapiens	4-8
20493880-7	2010	Using cysteine cross-linking, we confirmed that the promyelocytic leukemia zinc finger (PLZF) BTB dimer is strand exchanged in solution, while the FAZF BTB dimer is not.	btb	94-97	zinc finger and BTB domain containing 16	Homo sapiens	52-86
20493880-7	2010	Using cysteine cross-linking, we confirmed that the promyelocytic leukemia zinc finger (PLZF) BTB dimer is strand exchanged in solution, while the FAZF BTB dimer is not.	btb	94-97	zinc finger and BTB domain containing 16	Homo sapiens	88-92
20385364-3	2010	One such compound disrupted BCL6/corepressor complexes in vitro and in vivo, and was observed by X-ray crystallography and NMR to bind the critical site within the BTB groove.	btb	164-167	BCL6 corepressor	Homo sapiens	28-44
20419092-11	2010	CONCLUSIONS/SIGNIFICANCE: These findings suggest that PDE5 inhibitors may effectively modulate BTB permeability, and enhance delivery and therapeutic efficacy of monoclonal antibodies in hard-to-treat brain metastases from different primary tumors that had metastasized to the brain.	btb	95-98	phosphodiesterase 5A, cGMP-specific	Mus musculus	54-58
20065070-7	2010	This point mutation lies near the predicted charged pocket region of the EOR-1 BTB dimer, a region that, in other BTB-zinc finger proteins, has been proposed to interact with corepressors or coactivators.	btb	79-82	Uncharacterized protein	Caenorhabditis elegans	73-78
19918814-6	2010	In a well-ordered single-crystal state, BTB-1 adopts a relatively rare parallel conformation, and forms an interesting two-dimensional structure due to the presence of multiple directional intermolecular interactions, including C--HN and C--HS hydrogen-bonding interactions, and pi-pi stacking interactions.	btb	40-43	nuclear receptor subfamily 4 group A member 3	Homo sapiens	228-243
20174020-5	2010	Aimed to mitigate this BtB 3-dB penalty, further partial PTC approach is proposed for trading the PMD tolerance with the BtB OSNR sensitivity.	btb	23-26	proteolipid protein 1	Homo sapiens	98-101
19818708-0	2009	Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.	btb	81-84	cullin 3	Homo sapiens	85-89
20027226-4	2009	A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 was resistant to dh404-induced stabilization of Nrf2 protein.	btb	101-104	kelch like ECH associated protein 1	Homo sapiens	9-14
20027226-4	2009	A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 was resistant to dh404-induced stabilization of Nrf2 protein.	btb	101-104	kelch like ECH associated protein 1	Homo sapiens	115-120
20027226-4	2009	A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 was resistant to dh404-induced stabilization of Nrf2 protein.	btb	101-104	NFE2 like bZIP transcription factor 2	Homo sapiens	169-173
19782033-0	2009	Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.	btb	69-72	CDK2 associated cullin domain 1	Homo sapiens	0-6
19782033-0	2009	Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.	btb	69-72	ras homolog family member A	Homo sapiens	31-35
19782033-5	2009	We identify a family of RhoA-binding BTB domain adaptors conserved from insects to mammals, designated BACURDs.	btb	37-40	ras homolog family member A	Homo sapiens	24-28
19525324-1	2009	The Arabidopsis (Arabidopsis thaliana) gene BT2 encodes a 41-kD protein that possesses an amino-terminal BTB domain, a central TAZ domain, and a carboxyl-terminal calmodulin-binding domain.	btb	105-108	BTB and TAZ domain protein 2	Arabidopsis thaliana	44-47
19326437-6	2009	BTB permeability increased in all the experimental groups, accompanied by opening of local TJ of the BTB, observed by transmission electron microscopy, and decreased mRNA and protein expressions of ZO-1, occludin, and claudin-5.	btb	0-3	tight junction protein 1	Rattus norvegicus	198-202
19326437-6	2009	BTB permeability increased in all the experimental groups, accompanied by opening of local TJ of the BTB, observed by transmission electron microscopy, and decreased mRNA and protein expressions of ZO-1, occludin, and claudin-5.	btb	0-3	occludin	Rattus norvegicus	204-212
19326437-6	2009	BTB permeability increased in all the experimental groups, accompanied by opening of local TJ of the BTB, observed by transmission electron microscopy, and decreased mRNA and protein expressions of ZO-1, occludin, and claudin-5.	btb	0-3	claudin 5	Rattus norvegicus	218-227
19326437-9	2009	The down-regulation of TJ-related proteins ZO-1, occludin, and claudin-5 may be one of the underlying mechanisms of the increase in BTB permeability induced by LFU and BK.	btb	132-135	tight junction protein 1	Rattus norvegicus	43-47
19326437-9	2009	The down-regulation of TJ-related proteins ZO-1, occludin, and claudin-5 may be one of the underlying mechanisms of the increase in BTB permeability induced by LFU and BK.	btb	132-135	occludin	Rattus norvegicus	49-57
19326437-9	2009	The down-regulation of TJ-related proteins ZO-1, occludin, and claudin-5 may be one of the underlying mechanisms of the increase in BTB permeability induced by LFU and BK.	btb	132-135	claudin 5	Rattus norvegicus	63-72
18762809-3	2008	RhoBTB2/DBC2 is an atypical member of this family of signaling proteins, containing two BTB domains in addition to its conserved Rho GTPase domain.	btb	3-6	Rho related BTB domain containing 2	Homo sapiens	8-12
18927431-2	2009	BCL6 lymphomagenic activity is dependent on its ability to recruit corepressor proteins to a unique binding site on its N-terminal BTB domain.	btb	131-134	BCL6 transcription repressor	Homo sapiens	0-4
18808454-0	2009	The BTB ubiquitin ligases ETO1, EOL1 and EOL2 act collectively to regulate ethylene biosynthesis in Arabidopsis by controlling type-2 ACC synthase levels.	btb	4-7	tetratricopeptide repeat (TPR)-containing protein	Arabidopsis thaliana	26-30
18808454-0	2009	The BTB ubiquitin ligases ETO1, EOL1 and EOL2 act collectively to regulate ethylene biosynthesis in Arabidopsis by controlling type-2 ACC synthase levels.	btb	4-7	ETO1-like 1	Arabidopsis thaliana	32-36
18808454-0	2009	The BTB ubiquitin ligases ETO1, EOL1 and EOL2 act collectively to regulate ethylene biosynthesis in Arabidopsis by controlling type-2 ACC synthase levels.	btb	4-7	ETO1-like 2	Arabidopsis thaliana	41-45
18719355-4	2008	The cDNA of KLHL31 is 5743 bp long, encoding a protein product of 634 amino acids containing a BTB domain.	btb	95-98	kelch like family member 31	Homo sapiens	12-18
19121354-7	2009	Both the NAC1 isoforms demonstrated selective interaction through the POZ/BTB domain but not with the non-POZ/BTB region.	btb	74-77	nucleus accumbens associated 1	Homo sapiens	9-13
19121354-7	2009	Both the NAC1 isoforms demonstrated selective interaction through the POZ/BTB domain but not with the non-POZ/BTB region.	btb	110-113	nucleus accumbens associated 1	Homo sapiens	9-13
19190685-1	2009	OBJECTIVE: To investigate the underlying mechanism for the selective modulation of the permeability of blood-tumor barrier (BTB) by small dose of bradykinin (BK).	btb	124-127	kininogen 1	Homo sapiens	146-156
19190685-1	2009	OBJECTIVE: To investigate the underlying mechanism for the selective modulation of the permeability of blood-tumor barrier (BTB) by small dose of bradykinin (BK).	btb	124-127	kininogen 1	Homo sapiens	158-160
19190685-7	2009	CONCLUSION: These results suggested that BK triggered CICR in C6 glioma cells and the associated NO generation might be the underlying mechanism for the selective modulation of BTB permeability by BK.	btb	177-180	kininogen 1	Homo sapiens	41-43
19190685-7	2009	CONCLUSION: These results suggested that BK triggered CICR in C6 glioma cells and the associated NO generation might be the underlying mechanism for the selective modulation of BTB permeability by BK.	btb	177-180	kininogen 1	Homo sapiens	197-199
18983897-7	2009	Our results suggested that the bradykinin-mediated BTB permeability increase is due to accelerated release of TNF-alpha, which could cause the increase of BTB permeability by promoting to the release HSF1 from neurospongioma cells.	btb	51-54	tumor necrosis factor	Rattus norvegicus	110-119
18983897-7	2009	Our results suggested that the bradykinin-mediated BTB permeability increase is due to accelerated release of TNF-alpha, which could cause the increase of BTB permeability by promoting to the release HSF1 from neurospongioma cells.	btb	51-54	heat shock transcription factor 1	Rattus norvegicus	200-204
18983897-7	2009	Our results suggested that the bradykinin-mediated BTB permeability increase is due to accelerated release of TNF-alpha, which could cause the increase of BTB permeability by promoting to the release HSF1 from neurospongioma cells.	btb	155-158	tumor necrosis factor	Rattus norvegicus	110-119
18983897-7	2009	Our results suggested that the bradykinin-mediated BTB permeability increase is due to accelerated release of TNF-alpha, which could cause the increase of BTB permeability by promoting to the release HSF1 from neurospongioma cells.	btb	155-158	heat shock transcription factor 1	Rattus norvegicus	200-204
18835386-6	2008	We also show that RhoBTB2 and RhoBTB3 are capable of homo and heterodimerizing through the BTB domain region.	btb	21-24	Rho related BTB domain containing 3	Homo sapiens	30-37
18923083-5	2008	Here we report the isolation and characterization of a novel member of the BTB complex termed BLAP18/RMI2.	btb	75-78	RecQ mediated genome instability 2	Homo sapiens	94-100
18923083-5	2008	Here we report the isolation and characterization of a novel member of the BTB complex termed BLAP18/RMI2.	btb	75-78	RecQ mediated genome instability 2	Homo sapiens	101-105
18923083-6	2008	BLAP18/RMI2 contains a putative OB-fold domain, and several lines of evidence suggest that it is essential for BTB complex function.	btb	111-114	RecQ mediated genome instability 2	Homo sapiens	0-6
18923083-6	2008	BLAP18/RMI2 contains a putative OB-fold domain, and several lines of evidence suggest that it is essential for BTB complex function.	btb	111-114	RecQ mediated genome instability 2	Homo sapiens	7-11
18923083-8	2008	Second, depletion of BLAP18/RMI2 results in the destabilization of the BTB complex.	btb	71-74	RecQ mediated genome instability 2	Homo sapiens	21-27
18923083-8	2008	Second, depletion of BLAP18/RMI2 results in the destabilization of the BTB complex.	btb	71-74	RecQ mediated genome instability 2	Homo sapiens	28-32
18923083-11	2008	Finally, BLAP18/RMI2 stimulates the dHJ resolution capability of the BTB complex.	btb	69-72	RecQ mediated genome instability 2	Homo sapiens	9-15
18923083-11	2008	Finally, BLAP18/RMI2 stimulates the dHJ resolution capability of the BTB complex.	btb	69-72	RecQ mediated genome instability 2	Homo sapiens	16-20
17359538-4	2007	We showed that intravenous infusion of NS1619, a KCa channel agonist, and bradykinin selectively enhanced BTB permeability in brain tumors, but not in normal brain.	btb	106-109	kininogen 1	Homo sapiens	74-84
18390547-1	2008	The BLAP75 protein combines with the BLM helicase and topoisomerase (Topo) IIIalpha to form an evolutionarily conserved complex, termed the BTB complex, that functions to regulate homologous recombination.	btb	140-143	RecQ mediated genome instability 1	Homo sapiens	4-10
18390547-1	2008	The BLAP75 protein combines with the BLM helicase and topoisomerase (Topo) IIIalpha to form an evolutionarily conserved complex, termed the BTB complex, that functions to regulate homologous recombination.	btb	140-143	BLM RecQ like helicase	Homo sapiens	37-40
18390547-8	2008	This result provides proof that the functional integrity of the BTB complex is contingent upon the interaction of BLAP75 with Topo IIIalpha.	btb	64-67	RecQ mediated genome instability 1	Homo sapiens	114-120
18390547-8	2008	This result provides proof that the functional integrity of the BTB complex is contingent upon the interaction of BLAP75 with Topo IIIalpha.	btb	64-67	DNA topoisomerase III alpha	Homo sapiens	126-139
18183615-3	2008	In rat brain glioma model and BTB model in vitro, we find that the protein expression levels of ZO-1, occludin, and claudin-5 are attenuated by BK induction.	btb	30-33	tight junction protein 1	Rattus norvegicus	96-100
18183615-3	2008	In rat brain glioma model and BTB model in vitro, we find that the protein expression levels of ZO-1, occludin, and claudin-5 are attenuated by BK induction.	btb	30-33	claudin 5	Rattus norvegicus	116-125
18183615-10	2008	This study demonstrates that the increase of BK-mediated BTB permeability is associated with the down-regulation of ZO-1, occludin, and claudin-5 and the rearrangement of F-actin and that cAMP/PKA signal transduction system might be involved in the modulating process.	btb	57-60	tight junction protein 1	Rattus norvegicus	116-120
18183615-10	2008	This study demonstrates that the increase of BK-mediated BTB permeability is associated with the down-regulation of ZO-1, occludin, and claudin-5 and the rearrangement of F-actin and that cAMP/PKA signal transduction system might be involved in the modulating process.	btb	57-60	occludin	Rattus norvegicus	122-130
18183615-10	2008	This study demonstrates that the increase of BK-mediated BTB permeability is associated with the down-regulation of ZO-1, occludin, and claudin-5 and the rearrangement of F-actin and that cAMP/PKA signal transduction system might be involved in the modulating process.	btb	57-60	claudin 5	Rattus norvegicus	136-145
18573101-7	2008	Analysis of the interaction with cullin3 showed that, in addition to the BTB domain, some amino acids in the N-terminus of KCTD5 are required for binding to cullin3.	btb	73-76	potassium channel tetramerization domain containing 5	Homo sapiens	123-128
18256039-5	2008	While both Bach2 and Bcl6 possess the BTB domain which mediates protein-protein interactions, they interacted in a BTB-independent manner.	btb	38-41	BTB domain and CNC homolog 2	Homo sapiens	11-16
18256039-5	2008	While both Bach2 and Bcl6 possess the BTB domain which mediates protein-protein interactions, they interacted in a BTB-independent manner.	btb	38-41	BCL6 transcription repressor	Homo sapiens	21-25
19856171-2	2008	It is conceivable that this event involves extensive junction restructuring particularly at the blood-testis barrier (BTB, a structure that segregates the seminiferous epithelium into the basal and the adluminal compartments) that occurs at stages VII-VIII of the seminiferous epithelial cycle.	btb	118-121	cytochrome c oxidase subunit 8A	Homo sapiens	252-256
19856171-6	2008	We postulate the testis is using a similar mechanism during spermatogenesis at stage VIII of the epithelial cycle that these induced basal ES proteins, likely form a "patch" surrounding the BTB, transiently maintain the BTB integrity while TJ is "opened", such as induced by TGF-b3 or TNFa, to facilitate preleptotene spermatocyte migration.	btb	190-193	cytochrome c oxidase subunit 8A	Homo sapiens	85-89
17364824-6	2007	It shared 74% identity in amino acid sequence with Arabidopsis EOL1 and had one BTB (Broad-complex, Tramtrack, Bric-a-brac) domain and two TPR (tetratricopeptide repeat) domains, which were also conserved domains in AtEOL1.	btb	80-83	ETO1-like 1	Arabidopsis thaliana	63-67
17301088-2	2007	The BTB (broad complex, tramtrack, bric-a-brac)-zinc finger gene Zbtb20 (also known as HOF, Znf288, Zfp288) encodes two protein isoforms, designated Zbtb20(S) and Zbtb20(L), which are expressed in newborn pyramidal neurons of the presumptive hippocampus in mice.	btb	4-7	zinc finger and BTB domain containing 20	Mus musculus	65-71
17301088-2	2007	The BTB (broad complex, tramtrack, bric-a-brac)-zinc finger gene Zbtb20 (also known as HOF, Znf288, Zfp288) encodes two protein isoforms, designated Zbtb20(S) and Zbtb20(L), which are expressed in newborn pyramidal neurons of the presumptive hippocampus in mice.	btb	4-7	zinc finger and BTB domain containing 20	Mus musculus	87-90
17301088-2	2007	The BTB (broad complex, tramtrack, bric-a-brac)-zinc finger gene Zbtb20 (also known as HOF, Znf288, Zfp288) encodes two protein isoforms, designated Zbtb20(S) and Zbtb20(L), which are expressed in newborn pyramidal neurons of the presumptive hippocampus in mice.	btb	4-7	zinc finger and BTB domain containing 20	Mus musculus	100-106
17301088-2	2007	The BTB (broad complex, tramtrack, bric-a-brac)-zinc finger gene Zbtb20 (also known as HOF, Znf288, Zfp288) encodes two protein isoforms, designated Zbtb20(S) and Zbtb20(L), which are expressed in newborn pyramidal neurons of the presumptive hippocampus in mice.	btb	4-7	zinc finger and BTB domain containing 20	Mus musculus	149-155
17301088-2	2007	The BTB (broad complex, tramtrack, bric-a-brac)-zinc finger gene Zbtb20 (also known as HOF, Znf288, Zfp288) encodes two protein isoforms, designated Zbtb20(S) and Zbtb20(L), which are expressed in newborn pyramidal neurons of the presumptive hippocampus in mice.	btb	4-7	zinc finger and BTB domain containing 20	Mus musculus	149-155
16676348-2	2006	Here, a 45-kDa isoform of PLZF without a BTB domain was identified via yeast two-hybrid screening using the C-terminal region of ATP7B as bait in our determination of the biological roles of the Wilson disease protein outside of its copper-binding domain.	btb	41-44	zinc finger and BTB domain containing 16	Homo sapiens	26-30
18997279-4	2007	This study first proposes the proapoptotic aspect of the BTB/POZ domain of SPOP protein based on the finding that cells expressing the C-terminal fragment of SPOP containing the BTB/POZ domain underwent apoptosis.	btb	57-60	speckle type BTB/POZ protein	Homo sapiens	75-79
18997279-4	2007	This study first proposes the proapoptotic aspect of the BTB/POZ domain of SPOP protein based on the finding that cells expressing the C-terminal fragment of SPOP containing the BTB/POZ domain underwent apoptosis.	btb	57-60	speckle type BTB/POZ protein	Homo sapiens	158-162
16982692-8	2006	MRP2 interacted with GSK3beta through its NH2 terminus containing the BTB domain, and these molecules colocalized along neurite processes and growth cones in differentiated PC12 cells and rat primary hippocampal neurons.	btb	70-73	ATP binding cassette subfamily C member 2	Rattus norvegicus	0-4
16982692-8	2006	MRP2 interacted with GSK3beta through its NH2 terminus containing the BTB domain, and these molecules colocalized along neurite processes and growth cones in differentiated PC12 cells and rat primary hippocampal neurons.	btb	70-73	glycogen synthase kinase 3 beta	Rattus norvegicus	21-29
17189472-0	2007	Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator.	btb	25-28	zinc finger and BTB domain containing 7A	Homo sapiens	45-48
17189472-0	2007	Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator.	btb	25-28	zinc finger and BTB domain containing 7A	Homo sapiens	49-54
17189472-4	2007	We determined the crystal structure of the BTB domain from human LRF to 2.1 A and observed the canonical BTB homodimer fold.	btb	43-46	zinc finger and BTB domain containing 7A	Homo sapiens	65-68
17189472-4	2007	We determined the crystal structure of the BTB domain from human LRF to 2.1 A and observed the canonical BTB homodimer fold.	btb	105-108	zinc finger and BTB domain containing 7A	Homo sapiens	65-68
16718364-2	2006	Here, we obtained a novel member of human BTB/POZ protein family, named as ZBTB34 (Zinc finger and BTB domain containing 34), which encodes 504 amino acid residues with a BTB/POZ domain at its N-terminus that is similar to the same domain of other known transcription regulators.	btb	42-45	zinc finger and BTB domain containing 34	Homo sapiens	75-81
16690916-3	2006	VACV contains three genes predicted to encode BTB/kelch proteins: A55R, F3L and C2L.	btb	46-49	kelch-like protein	Vaccinia virus	66-70
16306221-3	2005	Based on three-dimensional modeling of NRP/B, we generated an NRP/B-BTB mutant containing three mutations in the conserved amino acids D47A, H60A and R61D that was termed BTB mutant A.	btb	171-174	ectodermal-neural cortex 1	Rattus norvegicus	39-44
16542149-6	2006	The interaction found in yeast was confirmed by co-immunoprecipitation and refined to the N-terminal region of ZNF297B-(1-127) containing the BTB/POZ domain and the N-terminal end of BDP1-(1-299).	btb	142-145	zinc finger and BTB domain containing 43	Homo sapiens	111-118
16542149-6	2006	The interaction found in yeast was confirmed by co-immunoprecipitation and refined to the N-terminal region of ZNF297B-(1-127) containing the BTB/POZ domain and the N-terminal end of BDP1-(1-299).	btb	142-145	transcription factor TFIIIB subunit BDP1	Saccharomyces cerevisiae S288C	183-187
16306221-3	2005	Based on three-dimensional modeling of NRP/B, we generated an NRP/B-BTB mutant containing three mutations in the conserved amino acids D47A, H60A and R61D that was termed BTB mutant A.	btb	171-174	Nrp	Rattus norvegicus	39-42
16306221-4	2005	BTB mutant A significantly reduced the dimerization of NRP/B compared to wild-type NRP/B.	btb	0-3	ectodermal-neural cortex 1	Rattus norvegicus	55-60
16306221-4	2005	BTB mutant A significantly reduced the dimerization of NRP/B compared to wild-type NRP/B.	btb	0-3	ectodermal-neural cortex 1	Rattus norvegicus	83-88
16306221-5	2005	The NRP/B-BTB domain was required for nuclear localization and mediated the association of NRP/B with p110RB through the TR subdomain within the B pocket of p110RB.	btb	10-13	ectodermal-neural cortex 1	Rattus norvegicus	4-9
16306221-5	2005	The NRP/B-BTB domain was required for nuclear localization and mediated the association of NRP/B with p110RB through the TR subdomain within the B pocket of p110RB.	btb	10-13	Nrp	Rattus norvegicus	4-7
16024608-0	2005	The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.	btb	43-46	zinc finger and BTB domain containing 16	Homo sapiens	148-152
16227972-5	2005	We present evidence that gigaxonin binds to the ubiquitin-activating enzyme E1 through its amino-terminal BTB domain, while the carboxy-terminal kelch repeat domain interacts directly with the light chain (LC) of microtubule-associated protein 1B (MAP1B).	btb	106-109	gigaxonin	Homo sapiens	25-34
16227972-5	2005	We present evidence that gigaxonin binds to the ubiquitin-activating enzyme E1 through its amino-terminal BTB domain, while the carboxy-terminal kelch repeat domain interacts directly with the light chain (LC) of microtubule-associated protein 1B (MAP1B).	btb	106-109	ubiquitin like modifier activating enzyme 7	Homo sapiens	48-78
16024608-0	2005	The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.	btb	43-46	retinoic acid receptor alpha	Homo sapiens	153-161
15772280-5	2005	Similar to the AtCUL1 subunit of the SKP1-CUL1-F-box protein-type E3 ligases, the AtCUL3 subunit of the BTB-containing E3 ligase complexes is subjected to modification and possible regulation by the ubiquitin-like protein Related to Ubiquitin in vivo.	btb	104-107	cullin 1	Arabidopsis thaliana	15-21
15772280-5	2005	Similar to the AtCUL1 subunit of the SKP1-CUL1-F-box protein-type E3 ligases, the AtCUL3 subunit of the BTB-containing E3 ligase complexes is subjected to modification and possible regulation by the ubiquitin-like protein Related to Ubiquitin in vivo.	btb	104-107	cullin 3	Arabidopsis thaliana	82-88
15618422-4	2005	Here, we show that Arabidopsis (Arabidopsis thaliana) AtCUL3 proteins interact in yeast two-hybrid and in vitro pull-down assays with proteins containing a BTB/POZ (broad complex, tramtrack, bric-a-brac/pox virus and zinc finger) motif.	btb	156-159	cullin 3	Arabidopsis thaliana	54-60
15601839-6	2005	Here we report that the human BTB-Kelch protein Keap1, a negative regulator of the antioxidative transcription factor Nrf2, binds to CUL3 and Nrf2 via its BTB and Kelch domains, respectively.	btb	30-33	kelch like ECH associated protein 1	Homo sapiens	48-53
15601839-6	2005	Here we report that the human BTB-Kelch protein Keap1, a negative regulator of the antioxidative transcription factor Nrf2, binds to CUL3 and Nrf2 via its BTB and Kelch domains, respectively.	btb	30-33	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
15601839-6	2005	Here we report that the human BTB-Kelch protein Keap1, a negative regulator of the antioxidative transcription factor Nrf2, binds to CUL3 and Nrf2 via its BTB and Kelch domains, respectively.	btb	30-33	cullin 3	Homo sapiens	133-137
15601839-6	2005	Here we report that the human BTB-Kelch protein Keap1, a negative regulator of the antioxidative transcription factor Nrf2, binds to CUL3 and Nrf2 via its BTB and Kelch domains, respectively.	btb	30-33	NFE2 like bZIP transcription factor 2	Homo sapiens	142-146
16207353-5	2005	In contrast, the Skp1 and ElonginC proteins consist almost exclusively of the core BTB fold.	btb	83-86	mammalian SKIP (Ski interacting protein) homolog	Caenorhabditis elegans	17-21
16207353-5	2005	In contrast, the Skp1 and ElonginC proteins consist almost exclusively of the core BTB fold.	btb	83-86	Elongin-C	Caenorhabditis elegans	26-34
16207353-7	2005	Using the structural homology between Skp1 and the PLZF BTB homodimer, we present a model of a BTB-Cul3 SCF-like E3 ubiquitin ligase complex that shows that the BTB dimer or the T1 tetramer is compatible in this complex.	btb	56-59	mammalian SKIP (Ski interacting protein) homolog	Caenorhabditis elegans	38-42
16207353-7	2005	Using the structural homology between Skp1 and the PLZF BTB homodimer, we present a model of a BTB-Cul3 SCF-like E3 ubiquitin ligase complex that shows that the BTB dimer or the T1 tetramer is compatible in this complex.	btb	95-98	mammalian SKIP (Ski interacting protein) homolog	Caenorhabditis elegans	38-42
15572695-6	2004	A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 is markedly resistant to inhibition by either quinone-induced oxidative stress or sulforaphane.	btb	101-104	kelch like ECH associated protein 1	Homo sapiens	9-14
15572695-6	2004	A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 is markedly resistant to inhibition by either quinone-induced oxidative stress or sulforaphane.	btb	101-104	kelch like ECH associated protein 1	Homo sapiens	115-120
12897787-2	2003	Lola has a zinc finger DNA binding domain and a BTB (for Broad-complex, Tramtrack and Bric a brac) dimerization motif.	btb	48-51	longitudinals lacking	Drosophila melanogaster	0-4
15231840-7	2004	The BTB/POZ domain inhibits the binding of HIC1 to a single site but mediates cooperative binding to a probe containing five concatemerized binding sites, a property shared by other BTB/POZ proteins.	btb	4-7	HIC ZBTB transcriptional repressor 1	Homo sapiens	43-47
15367669-2	2004	Nrf2 activity is opposed by the BTB/POZ domain protein Keap1.	btb	32-35	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
15367669-2	2004	Nrf2 activity is opposed by the BTB/POZ domain protein Keap1.	btb	32-35	kelch like ECH associated protein 1	Homo sapiens	55-60
15448697-3	2004	Here, we report that human UV-damaged DNA-binding protein DDB1 associates stoichiometrically with CUL4A in vivo, and binds to an amino-terminal region in CUL4A in a manner analogous to SKP1, SOCS and BTB binding to CUL1, CUL2 and CUL3, respectively.	btb	200-203	damage specific DNA binding protein 1	Homo sapiens	58-62
15363856-4	2004	These genes showed 90.3% and 98.2% amino acid identity with the Drosophila BR-C and Manduca BR-C in the N-terminal BTB domain; 96.0%, 90.7%, and 85.2% identity with the three zinc finger domains of the Drosophila Z1, Z2, and Z4 isoforms; and 96.3% and 98.1% identity with the two zinc finger domains of the Manduca Z2 and Z4 isoforms, respectively.	btb	115-118	brc	Drosophila melanogaster	75-79
15363856-4	2004	These genes showed 90.3% and 98.2% amino acid identity with the Drosophila BR-C and Manduca BR-C in the N-terminal BTB domain; 96.0%, 90.7%, and 85.2% identity with the three zinc finger domains of the Drosophila Z1, Z2, and Z4 isoforms; and 96.3% and 98.1% identity with the two zinc finger domains of the Manduca Z2 and Z4 isoforms, respectively.	btb	115-118	brc	Drosophila melanogaster	92-96
15208678-6	2004	NRP/B mutations (13 mutations in the Kelch domains, two in the intervening sequence (IVS) domain and two in the BTB domain) were detected in brain tumor cell lines (A-172, CCF-STTG1, SK-N-SH and U87-MG) and in primary human malignant GBM tissues (eight samples).	btb	112-115	ectodermal-neural cortex 1	Homo sapiens	0-5
12897787-2	2003	Lola has a zinc finger DNA binding domain and a BTB (for Broad-complex, Tramtrack and Bric a brac) dimerization motif.	btb	48-51	tramtrack	Drosophila melanogaster	72-81
12500695-2	2002	This study investigated whether elevation of the B2R expression levels on glioma cells enhances BK-mediated BTB permeability increases.	btb	108-111	bradykinin receptor B2	Rattus norvegicus	49-52
12659862-4	2003	The BTB/POZ domain and the middle portion of BAZF bound to the BTB/POZ domain and the middle portion of Bcl6, respectively.	btb	4-7	B cell leukemia/lymphoma 6	Mus musculus	104-108
12723696-5	2003	All Mod(mdg4) protein isoforms share a common N-terminal region of 402 amino acids, which includes the conserved BTB/POZ domain.	btb	113-116	modifier of mdg4	Drosophila melanogaster	4-12
12500695-9	2002	These results suggested that alteration of B2R expression levels on tumor cells could modulate BK-mediated BTB permeability.	btb	107-110	bradykinin receptor B2	Rattus norvegicus	43-46
12500695-10	2002	Therefore, B2R expression levels in human glioma could be used to analyze the treatment results of patients undergoing treatment involving BK-modulated BTB permeability.	btb	152-155	bradykinin receptor B2	Homo sapiens	11-14
12213805-2	2002	Nd1-L contains a BTB/POZ domain in its N terminus and six kelch repeats in the C terminus.	btb	17-20	influenza virus NS1A binding protein	Mus musculus	0-5
12213805-5	2002	Nd1-L and Nd1-S proteins can form a dimer through the BTB/POZ domain.	btb	54-57	influenza virus NS1A binding protein	Mus musculus	0-5
12213805-5	2002	Nd1-L and Nd1-S proteins can form a dimer through the BTB/POZ domain.	btb	54-57	influenza virus NS1A binding protein	Mus musculus	10-15
11751886-5	2002	XKaiso contains an amino-terminal BTB/POZ domain and three carboxyl-terminal zinc fingers.	btb	34-37	zinc finger and BTB domain containing 33 S homeolog	Xenopus laevis	0-6
12193649-9	2002	These residues are located in the intervening region between BTB and Kelch repeat domains of Keap1 and probably are the direct sensors of inducers of the phase 2 system.	btb	61-64	kelch-like ECH-associated protein 1	Mus musculus	93-98
11554746-4	2001	Alignment of the HRG22 and HIC1 proteins from various species revealed high sequence homology in their N-terminal BTB/POZ and five C-terminal C(2)H(2) zinc finger domains and highlighted a conserved GLDLSKK/R peptide in their middle region.	btb	114-117	HIC ZBTB transcriptional repressor 2	Homo sapiens	17-22
11865059-2	2002	The highly conserved N-terminal BTB (bric a brac, tramtrack, broad complex)/POZ domain of PLZF plays a critical role in this disease, since it is required for transcriptional repression by the PLZF-RARalpha fusion protein.	btb	32-35	zinc finger and BTB domain containing 16	Homo sapiens	90-94
11865059-2	2002	The highly conserved N-terminal BTB (bric a brac, tramtrack, broad complex)/POZ domain of PLZF plays a critical role in this disease, since it is required for transcriptional repression by the PLZF-RARalpha fusion protein.	btb	32-35	zinc finger and BTB domain containing 16	Homo sapiens	193-197
11865059-2	2002	The highly conserved N-terminal BTB (bric a brac, tramtrack, broad complex)/POZ domain of PLZF plays a critical role in this disease, since it is required for transcriptional repression by the PLZF-RARalpha fusion protein.	btb	32-35	retinoic acid receptor alpha	Homo sapiens	198-206
11865059-9	2002	A comparison of the PLZF, Bcl-6, and the FAZF (Fanconi anemia zinc finger)/ROG protein shows that variations in the BTB pocket result in differential affinity for corepressors, which predicts the potency of transcriptional repression.	btb	116-119	zinc finger and BTB domain containing 16	Homo sapiens	20-24
11865059-9	2002	A comparison of the PLZF, Bcl-6, and the FAZF (Fanconi anemia zinc finger)/ROG protein shows that variations in the BTB pocket result in differential affinity for corepressors, which predicts the potency of transcriptional repression.	btb	116-119	BCL6 transcription repressor	Homo sapiens	26-31
11865059-9	2002	A comparison of the PLZF, Bcl-6, and the FAZF (Fanconi anemia zinc finger)/ROG protein shows that variations in the BTB pocket result in differential affinity for corepressors, which predicts the potency of transcriptional repression.	btb	116-119	zinc finger and BTB domain containing 32	Homo sapiens	41-45
11865059-9	2002	A comparison of the PLZF, Bcl-6, and the FAZF (Fanconi anemia zinc finger)/ROG protein shows that variations in the BTB pocket result in differential affinity for corepressors, which predicts the potency of transcriptional repression.	btb	116-119	zinc finger and BTB domain containing 32	Homo sapiens	47-73
11719366-8	2001	Deletion of the BTB/POZ domain significantly relieved PLZF-mediated repression of 1,25(OH)(2)D(3)-dependent activation.	btb	16-19	zinc finger and BTB domain containing 16	Homo sapiens	54-58
11554746-4	2001	Alignment of the HRG22 and HIC1 proteins from various species revealed high sequence homology in their N-terminal BTB/POZ and five C-terminal C(2)H(2) zinc finger domains and highlighted a conserved GLDLSKK/R peptide in their middle region.	btb	114-117	HIC ZBTB transcriptional repressor 1	Homo sapiens	27-31
11591818-2	2001	Using the yeast two-hybrid system, we have cloned a novel LAP2beta-binding protein, mGCL, which contains a BTB/POZ domain and is the mouse homologue of the Drosophila germ-cell-less (GCL) protein.	btb	107-110	germ cell-less, spermatogenesis associated 1	Mus musculus	84-88
11591818-2	2001	Using the yeast two-hybrid system, we have cloned a novel LAP2beta-binding protein, mGCL, which contains a BTB/POZ domain and is the mouse homologue of the Drosophila germ-cell-less (GCL) protein.	btb	107-110	germ cell-less	Drosophila melanogaster	167-181
11591818-2	2001	Using the yeast two-hybrid system, we have cloned a novel LAP2beta-binding protein, mGCL, which contains a BTB/POZ domain and is the mouse homologue of the Drosophila germ-cell-less (GCL) protein.	btb	107-110	germ cell-less 2, spermatogenesis associated	Homo sapiens	85-88
11279021-7	2001	Furthermore, we showed that the N-terminal BTB/POZ domain of TZFP has a repressor activity.	btb	43-46	zinc finger and BTB domain containing 32	Mus musculus	61-65
11536049-5	2001	The 584 residue MIPP protein has an N-terminal BTB domain and six C-terminal tandem Kelch repeats.	btb	47-50	IAP promoted placental gene	Mus musculus	16-20
11024164-0	2000	Functional studies of the BTB domain in the Drosophila GAGA and Mod(mdg4) proteins.	btb	26-29	Trithorax-like	Drosophila melanogaster	55-59
11062483-7	2000	Gigaxonin is composed of an amino-terminal BTB (for Broad-Complex, Tramtrack and Bric a brac) domain followed by a six kelch repeats, which are predicted to adopt a beta-propeller shape.	btb	43-46	gigaxonin	Homo sapiens	0-9
11024164-0	2000	Functional studies of the BTB domain in the Drosophila GAGA and Mod(mdg4) proteins.	btb	26-29	modifier of mdg4	Drosophila melanogaster	64-72
10978285-5	2000	We show that the BTB domain is essential for Ttk69 function and single amino acid changes in highly conserved residues in this domain abolish Ttk69 activity.	btb	17-20	tramtrack	Drosophila melanogaster	45-50
10978285-5	2000	We show that the BTB domain is essential for Ttk69 function and single amino acid changes in highly conserved residues in this domain abolish Ttk69 activity.	btb	17-20	tramtrack	Drosophila melanogaster	142-147
10978285-6	2000	Interestingly, the Ttk69 BTB can be substituted by the BTB of the human Bcl-6 protein, suggesting that BTB function has been conserved between Drosophila and humans.	btb	25-28	tramtrack	Drosophila melanogaster	19-24
10978285-6	2000	Interestingly, the Ttk69 BTB can be substituted by the BTB of the human Bcl-6 protein, suggesting that BTB function has been conserved between Drosophila and humans.	btb	55-58	BCL6 transcription repressor	Homo sapiens	72-77
10978285-6	2000	Interestingly, the Ttk69 BTB can be substituted by the BTB of the human Bcl-6 protein, suggesting that BTB function has been conserved between Drosophila and humans.	btb	55-58	BCL6 transcription repressor	Homo sapiens	72-77
10669750-6	2000	MAZR forms homo- and hetero-oligomers with Bach2 through the BTB domain, which oligomers bind to guanine-rich sequences.	btb	61-64	POZ (BTB) and AT hook containing zinc finger 1	Mus musculus	0-4
10938130-13	2000	These results indicate that PLZF requires the BTB/POZ domain for dimerization and the charged pocket for transcriptional repression.	btb	46-49	zinc finger and BTB domain containing 16	Homo sapiens	28-32
10873615-3	2000	This molecule, called myoneurin on the basis of its prevalent expression in the neuromuscular system, contains an amino-terminal BTB/POZ domain and eight tandemly repeated zinc-finger motifs of the C(2)H(2) type.	btb	129-132	myoneurin	Homo sapiens	22-31
10669750-6	2000	MAZR forms homo- and hetero-oligomers with Bach2 through the BTB domain, which oligomers bind to guanine-rich sequences.	btb	61-64	BTB and CNC homology, basic leucine zipper transcription factor 2	Mus musculus	43-48
10611298-4	1999	This insertion, located in a conserved region involved in the dimerization and scaffolding of the BTB/POZ domain, mainly affects slightly the ability of the HIC-1 and gammaFBP-B BTB/POZ domains to homo- and heterodimerize in vivo, as shown by mammalian two-hybrid experiments.	btb	98-101	HIC ZBTB transcriptional repressor 1	Homo sapiens	157-162
10620011-8	1999	Furthermore, in transfection studies we found that Bach1 repressed the enhancer activity of the LCR in a BTB/POZ domain-dependent manner.	btb	105-108	BTB domain and CNC homolog 1	Homo sapiens	51-56
10572087-5	1999	We show that the novel gene, FAZF, encodes a 486 amino acid protein containing a conserved amino terminal BTB/POZ protein interaction domain and three C-terminal Kruppel-like zinc fingers.	btb	106-109	zinc finger and BTB domain containing 32	Homo sapiens	29-33
10375692-3	1999	In this study, we examined the effects of glioma cell SF/HGF expression on BTB permeability to horseradish peroxidase (HRP).	btb	75-78	hepatocyte growth factor	Rattus norvegicus	57-60
10375692-10	1999	These data demonstrate that SF/HGF expression by intracerebral glial tumors can enhance BTB permeability independent of changes in VEGF/VPF expression.	btb	88-91	hepatocyte growth factor	Rattus norvegicus	28-34
10397770-3	1999	Mayven contains a BTB (broad complex, tramtrack, bric-a-brac)/POZ (poxvirus, zinc finger) domain-like structure in the predicted N terminus and "kelch repeats" in the predicted C-terminal domain.	btb	18-21	kelch like family member 2	Homo sapiens	0-6
10397770-6	1999	The BTB/POZ domain of Mayven can self-dimerize in vitro, which might be important for its interaction with other BTB/POZ-containing proteins.	btb	4-7	kelch like family member 2	Homo sapiens	22-28
9838134-1	1998	HIC-1 (hypermethylated in cancer), a new candidate tumor suppressor gene located in 17p13.3, encodes a protein with five Kruppel-like C2H2 zinc finger motifs and a N-terminal protein-protein interaction domain called BTB/POZ.	btb	217-220	HIC ZBTB transcriptional repressor 1	Homo sapiens	0-5
9927205-1	1999	The BCL-6 proto-oncogene encodes a 92- to 98-kDa transcriptional repressor containing the BTB/POZ domain at its N-terminal region and the zinc finger domain at its C-terminal region, respectively.	btb	90-93	BCL6 transcription repressor	Homo sapiens	4-9
9696811-3	1998	NS1-BP contains an N-terminal BTB/POZ domain and five kelch-like tandem repeat elements of approximately 50 amino acids.	btb	30-33	influenza virus NS1A binding protein	Homo sapiens	0-6
9808776-1	1998	A cDNA homolog of the Drosophila melanogaster Broad Complex (BRC) gene was isolated from the tobacco hornworm, Manduca sexta, which shows a predicted 88% amino acid identity with Drosophila BRC in the N-terminal BTB domain.	btb	212-215	brc	Drosophila melanogaster	46-65
9808776-1	1998	A cDNA homolog of the Drosophila melanogaster Broad Complex (BRC) gene was isolated from the tobacco hornworm, Manduca sexta, which shows a predicted 88% amino acid identity with Drosophila BRC in the N-terminal BTB domain.	btb	212-215	brc	Drosophila melanogaster	61-64
9770450-0	1998	Crystal structure of the BTB domain from PLZF.	btb	25-28	zinc finger and BTB domain containing 16	Homo sapiens	41-45
8972229-0	1997	Molecular cloning and characterization of a transcription factor for the copia retrotransposon with homology to the BTB-containing lola neurogenic factor.	btb	116-119	longitudinals lacking	Drosophila melanogaster	131-135
9713849-7	1998	At 30 min of bradykinin infusion, BTB permeability was significantly lower compared to 15 min of bradykinin infusion (3.79 +/- 0.99 vs. 16.20 +/- 3.43 microliters g-1 min-1, p < 0.001).	btb	34-37	kininogen 1	Homo sapiens	13-23
9713849-8	1998	Pretreatment with an NO donor significantly decreased BTB permeability in bradykinin infused rats (5.09 +/- 2.61 vs. 13.51 +/- 4.19 microliters g-1 min-1, p < 0.001), as did pretreatment with a cyclic GMP analogue (4.48 +/- 0.95 vs. 12.31 +/- 3.90 microliters g-1 min-1, p < 0.001).	btb	54-57	kininogen 1	Homo sapiens	74-84
9566959-2	1998	We have discovered a novel nuclear matrix protein, NRP/B (nuclear restricted protein/brain), which contains two major structural elements: a BTB domain-like structure in the predicted NH2 terminus, and a "kelch motif" in the predicted COOH-terminal domain.	btb	141-144	ectodermal-neural cortex 1	Homo sapiens	51-56
9531570-7	1998	It appears that N-CoR/histone deacetylase corepressor complex interacts directly in an ATRA-insensitive manner with the BTB/POZ-domain of the wild-type PLZF protein and is required, at least in part, for its function as a transcriptional repressor.	btb	120-123	nuclear receptor corepressor 1	Homo sapiens	16-21
9531570-7	1998	It appears that N-CoR/histone deacetylase corepressor complex interacts directly in an ATRA-insensitive manner with the BTB/POZ-domain of the wild-type PLZF protein and is required, at least in part, for its function as a transcriptional repressor.	btb	120-123	zinc finger and BTB domain containing 16	Homo sapiens	152-156
9177479-4	1997	Immunofluorescence studies revealed that HA-tagged hZF5 transiently expressed in COS-7 cells showed the nuclear dot pattern in the BTB/POZ domain-dependent manner.	btb	131-134	zinc finger and BTB domain containing 14	Homo sapiens	51-55
9341182-5	1997	We have overexpressed, purified, characterized, and crystallized the BTB/POZ domain from PLZF (PLZF-BTB/POZ).	btb	69-72	zinc finger and BTB domain containing 16	Homo sapiens	89-93
9341182-5	1997	We have overexpressed, purified, characterized, and crystallized the BTB/POZ domain from PLZF (PLZF-BTB/POZ).	btb	69-72	zinc finger and BTB domain containing 16	Homo sapiens	95-107
9019154-8	1995	Indeed, on the LAZ3/BCL6 cognate sequence, deletion of the BTB/POZ domain diminishes the repressive function.	btb	59-62	BCL6 transcription repressor	Homo sapiens	15-19
9019154-8	1995	Indeed, on the LAZ3/BCL6 cognate sequence, deletion of the BTB/POZ domain diminishes the repressive function.	btb	59-62	BCL6 transcription repressor	Homo sapiens	20-24
34819492-8	2021	Highly expressed HNF4G directly bound to the promoters of TJPs ZO-1, occludin and claudin-5 to promote their transcriptional activities and regulated BTB permeability.	btb	150-153	hepatocyte nuclear factor 4 gamma	Homo sapiens	17-22
7760839-2	1995	bab encodes a BTB domain (also called a POZ domain), an approximately 115-amino-acid conserved motif found primarily in the N termini of zinc finger proteins.	btb	14-17	bric a brac 1	Drosophila melanogaster	0-3
7760839-3	1995	In this paper, we show that the BTB domain of bab can mediate protein dimerization in vitro.	btb	32-35	bric a brac 1	Drosophila melanogaster	46-49
34819492-10	2021	In conclusion, the current study indicated that RPL32P3 knockdown increased BTB permeability through the YBX2/HNF4G pathway.	btb	76-79	Y-box binding protein 2	Homo sapiens	105-109
34819492-10	2021	In conclusion, the current study indicated that RPL32P3 knockdown increased BTB permeability through the YBX2/HNF4G pathway.	btb	76-79	hepatocyte nuclear factor 4 gamma	Homo sapiens	110-115
34739823-2	2021	describe an exposed binding site in the MIZ1 BTB domain due to an atypical flexible region within the BTB core.	btb	102-105	zinc finger and BTB domain containing 17	Homo sapiens	40-44
34830280-7	2021	Pita and Su(Hw) have two unstructured regions that appear to simultaneously interact with hydrophobic grooves in the BTB dimer.	btb	117-120	pita	Drosophila melanogaster	0-4
34830280-7	2021	Pita and Su(Hw) have two unstructured regions that appear to simultaneously interact with hydrophobic grooves in the BTB dimer.	btb	117-120	suppressor of Hairy wing	Drosophila melanogaster	9-15
34830280-8	2021	In dCTCF and CG31365, two adjacent regions interact simultaneously with the hydrophobic groove of the BTB and the M domain of CP190.	btb	102-105	CTCF	Drosophila melanogaster	3-8
34739823-3	2021	This site allows HECT-type ubiquitin ligase 1 to bind the MIZ1 homodimer by forming beta strands and completing the canonical BTB fold.	btb	126-129	zinc finger and BTB domain containing 17	Homo sapiens	58-62
34287839-2	2021	The available BCL6 BTB-specific inhibitors are poorly water soluble thus limiting their absorption in vivo and our understanding of therapeutic strategy targeting GC.	btb	19-22	B cell leukemia/lymphoma 6	Mus musculus	14-18
34189645-1	2021	The Drosophila TTK protein is involved in the processes of cell differentiation and is represented by two isoforms, TTK69 and TTK88, which have a common N-terminal BTB domain and different C-terminal sequences.	btb	164-167	tramtrack	Drosophila melanogaster	15-18
34580275-7	2021	Abnormal beta-catenin accumulation resulted in impaired testicular junction integrity, thus led to abnormal structure and functions of BTB.	btb	135-138	catenin (cadherin associated protein), beta 1	Mus musculus	9-21
34189645-1	2021	The Drosophila TTK protein is involved in the processes of cell differentiation and is represented by two isoforms, TTK69 and TTK88, which have a common N-terminal BTB domain and different C-terminal sequences.	btb	164-167	tramtrack	Drosophila melanogaster	116-121
34189645-1	2021	The Drosophila TTK protein is involved in the processes of cell differentiation and is represented by two isoforms, TTK69 and TTK88, which have a common N-terminal BTB domain and different C-terminal sequences.	btb	164-167	tramtrack	Drosophila melanogaster	126-131
34998172-5	2022	Therefore, serine hydroxymethyltransferase 1 (SHMT1) siRNA-loaded nanochains not only demonstrated to transmigrate the BTB, but also resulted in remarkably reducing the tumor size to 97% in the glioblastoma xenograft brain tumor mouse models.	btb	119-122	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	11-44
34998172-5	2022	Therefore, serine hydroxymethyltransferase 1 (SHMT1) siRNA-loaded nanochains not only demonstrated to transmigrate the BTB, but also resulted in remarkably reducing the tumor size to 97% in the glioblastoma xenograft brain tumor mouse models.	btb	119-122	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	46-51
32713259-6	2020	The low expression of ZNF765 was discovered in GECs and verified to increase BTB permeability by inhibiting the promoter activities of tight junction-related proteins.	btb	77-80	zinc finger protein 765	Homo sapiens	22-28
3379140-4	1988	The extravascular extraction of [3H]TeBG across the BTB or prostate plasma membrane [73 +/- 2% (+/- SE) and 92 +/- 9%, respectively] was significantly greater than extraction of [3H]albumin or other plasma space markers and indicative of a rapid first pass clearance of TeBG by Sertoli or prostate cells.	btb	52-55	sex hormone binding globulin	Homo sapiens	36-40
33238752-0	2021	BTB and CNC homology 1 inhibition ameliorates fibrosis and inflammation via blocking ERK pathway in pulmonary fibrosis.	btb	0-3	mitogen-activated protein kinase 1	Mus musculus	85-88
33452490-5	2021	More recently, accumulating evidence has demonstrated the essential roles of CRL3 E3s, consisting of a CUL3 protein and a BTB/POZ substrate adaptor.	btb	122-125	interleukin 31 receptor A	Homo sapiens	77-81
35052618-3	2022	In the present study, we have identified that BAP1 deubiquitinates KEAP1 by binding to the BTB domain.	btb	91-94	BRCA1 associated protein 1	Homo sapiens	46-50
35052618-3	2022	In the present study, we have identified that BAP1 deubiquitinates KEAP1 by binding to the BTB domain.	btb	91-94	kelch like ECH associated protein 1	Homo sapiens	67-72
33893670-4	2021	The BK ligand can prompt BTB adenosine receptor activation, which enhances transportation and accumulation inside tumors, as confirmed by T1 -weighted magnetic resonance and fluorescence imaging.	btb	25-28	synaptotagmin XVII	Mus musculus	4-6
33792302-9	2021	We identify G248R and R283Q as damaging mutations involved in the recognition process of the substrate RIT1 and R412C as a possible allosteric mutation from the Kelch to the C-term BTB-domain.	btb	181-184	Ras like without CAAX 1	Homo sapiens	103-107
33452577-11	2021	The percent increase in Group 3-6 m., 7-12 m., 1-2 y., 2-3 y., 3-4 y., and 4 y.- was significantly greater than that in Group 0-2 m. CONCLUSIONS: The CSA of the BTB autografts after the ART BTB ACLR increases rapidly by 3-6 months after ACLR, reached a maximum value of 190% at around 1 year, decreases gradually after that, and reaches a plateau at around 3 years.	btb	161-164	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	150-153
30704307-3	2020	The intracellular adhesion molecule-1 (ICAM-1) is a member of the immunoglobulin cell adhesion molecule family and is a constituent component of the BTB.	btb	149-152	intercellular adhesion molecule 1	Homo sapiens	4-37
30704307-3	2020	The intracellular adhesion molecule-1 (ICAM-1) is a member of the immunoglobulin cell adhesion molecule family and is a constituent component of the BTB.	btb	149-152	intercellular adhesion molecule 1	Homo sapiens	39-45
32713259-7	2020	Meanwhile, ZNF765 also inhibited the transcriptional activity of IGF2BP2, thereby forming a feedback loop in regulating the BTB permeability.	btb	124-127	zinc finger protein 765	Homo sapiens	11-17
32713259-7	2020	Meanwhile, ZNF765 also inhibited the transcriptional activity of IGF2BP2, thereby forming a feedback loop in regulating the BTB permeability.	btb	124-127	insulin like growth factor 2 mRNA binding protein 2	Homo sapiens	65-72
32713259-9	2020	In general, our study revealed the regulation mechanism of IGF2BP2/FBXL19-AS1/ZNF765 axis on BTB permeability, which may provide valuable insight into treatment strategy for glioma.	btb	93-96	insulin like growth factor 2 mRNA binding protein 2	Homo sapiens	59-66
32713259-9	2020	In general, our study revealed the regulation mechanism of IGF2BP2/FBXL19-AS1/ZNF765 axis on BTB permeability, which may provide valuable insight into treatment strategy for glioma.	btb	93-96	F-box and leucine rich repeat protein 19	Homo sapiens	67-73
32713259-9	2020	In general, our study revealed the regulation mechanism of IGF2BP2/FBXL19-AS1/ZNF765 axis on BTB permeability, which may provide valuable insight into treatment strategy for glioma.	btb	93-96	prostaglandin D2 receptor	Homo sapiens	74-77
32713259-9	2020	In general, our study revealed the regulation mechanism of IGF2BP2/FBXL19-AS1/ZNF765 axis on BTB permeability, which may provide valuable insight into treatment strategy for glioma.	btb	93-96	zinc finger protein 765	Homo sapiens	78-84
33127881-6	2020	MiR-140-3p silencing resulted in an increase in BTB permeability by targeting ZAK, while overexpression of miR-140-3p had the opposite results in GECs of BTB.	btb	48-51	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	78-81
33127881-7	2020	Overexpression of ZAK induced an increase in BTB permeability, and this effect was related to ZAK"s ability to mediate phosphorylation of NFkappaB-p65.	btb	45-48	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	18-21
33127881-7	2020	Overexpression of ZAK induced an increase in BTB permeability, and this effect was related to ZAK"s ability to mediate phosphorylation of NFkappaB-p65.	btb	45-48	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	94-97
33127881-7	2020	Overexpression of ZAK induced an increase in BTB permeability, and this effect was related to ZAK"s ability to mediate phosphorylation of NFkappaB-p65.	btb	45-48	RELA proto-oncogene, NF-kB subunit	Homo sapiens	138-150
33127881-8	2020	Conversely, ZAK silencing get opposite results in GECs of BTB.	btb	58-61	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	12-15
33127881-11	2020	Single or combined application of MIAT and miR-140-3p effectively promoted antitumor drug doxorubicin (Dox) across BTB to induce apoptosis of glioma cells.	btb	115-118	myocardial infarction associated transcript	Homo sapiens	34-38
32623796-5	2020	Moreover, overexpression of PTBP1 significantly reversed the increase in BTB permeability caused by siLnc00462717.	btb	73-76	polypyrimidine tract binding protein 1	Mus musculus	28-33
32814905-4	2020	We find that SCF-FBXL17 disrupts aberrant BTB dimers that fail to stabilize an intermolecular beta-sheet around a highly divergent beta-strand of the BTB domain.	btb	42-45	KIT ligand	Homo sapiens	13-16
32814905-4	2020	We find that SCF-FBXL17 disrupts aberrant BTB dimers that fail to stabilize an intermolecular beta-sheet around a highly divergent beta-strand of the BTB domain.	btb	42-45	F-box and leucine rich repeat protein 17	Homo sapiens	17-23
30586619-2	2019	In CUL3-based CRLs, the substrate specificity is conferred by the interaction with one of around 183 existing BTB proteins, implying a broad spectrum of possible ubiquitylation signals and possible direct ubiquitylation substrates.	btb	110-113	cullin 3	Homo sapiens	3-7
31898230-4	2020	Differently, a single BTB-containing adaptor molecule utilizing two protein interaction sites can link the CUL3 scaffold to the substrate, forming as many as 188 CUL3-BTB E3 ligase complexes in mammals.	btb	22-25	cullin 3	Homo sapiens	107-111
31690515-10	2020	Men with BTB had higher PSA (9.7 vs. 6.7 ng/mL, p = 0.029), PSAD (0.27 vs. 0.16, p = 0.007), GG (3.3 vs. 1.8, p < 0.001), more bilateral disease (75.9% vs. 55.6%, odds ratio 3.9, p = 0.008), and PCs (10.9 vs. 4.4, p < 0.001).	btb	9-12	kallikrein related peptidase 3	Homo sapiens	24-27
31295462-4	2019	To confirm the molecular targets of new derivatives in NRf2 and NFkappaB pathways the docking at Kelch and BTB active sites of Keap1 as well as IKK was done.	btb	107-110	NFE2 like bZIP transcription factor 2	Homo sapiens	55-59
31295462-4	2019	To confirm the molecular targets of new derivatives in NRf2 and NFkappaB pathways the docking at Kelch and BTB active sites of Keap1 as well as IKK was done.	btb	107-110	nuclear factor kappa B subunit 1	Homo sapiens	64-72
31295462-4	2019	To confirm the molecular targets of new derivatives in NRf2 and NFkappaB pathways the docking at Kelch and BTB active sites of Keap1 as well as IKK was done.	btb	107-110	kelch like ECH associated protein 1	Homo sapiens	127-132
32496219-3	2020	PATZ1 exerts its activity through an N-terminal BTB domain that mediates dimerization and co-repressor interactions and a C-terminal zinc-finger motif-containing domain that mediates DNA binding.	btb	48-51	POZ/BTB and AT hook containing zinc finger 1	Homo sapiens	0-5
31957918-7	2020	Dioscorea zingiberensis effectively increased ZO-1 expression in testis tissue to restore the integrity of the BTB.	btb	111-114	tight junction protein 1	Mus musculus	46-50
31484080-7	2019	Our findings link Psq variants lacking the BTB domain to Pc-bound active enhancers, thus shedding light into their molecular function in chromatin changes underlying the response to hormone stimulus.	btb	43-46	Polycomb	Drosophila melanogaster	57-59
29466066-8	2019	Results: In the BTB group, significant anterior reach, single hop, triple hops, and cross-over hops deficits were observed on the ACLR limb compared with the uninvolved limb.	btb	16-19	HOP homeobox	Homo sapiens	62-65
31296839-8	2019	The overexpressed miR-577 increased the permeability of BTB by reducing the tight junction-related protein expressions, and vice versa.	btb	56-59	microRNA 577	Homo sapiens	18-25
31296839-9	2019	Furthermore, cDENND4C acted as a molecular sponge of miR-577, which bound to miR-577 and inhibited its negative regulation of target genes ZO-1, occludin and claudin-1 to regulate BTB permeability.	btb	180-183	microRNA 577	Homo sapiens	53-60
31296839-9	2019	Furthermore, cDENND4C acted as a molecular sponge of miR-577, which bound to miR-577 and inhibited its negative regulation of target genes ZO-1, occludin and claudin-1 to regulate BTB permeability.	btb	180-183	microRNA 577	Homo sapiens	77-84
31296839-9	2019	Furthermore, cDENND4C acted as a molecular sponge of miR-577, which bound to miR-577 and inhibited its negative regulation of target genes ZO-1, occludin and claudin-1 to regulate BTB permeability.	btb	180-183	occludin	Homo sapiens	145-153
31296839-9	2019	Furthermore, cDENND4C acted as a molecular sponge of miR-577, which bound to miR-577 and inhibited its negative regulation of target genes ZO-1, occludin and claudin-1 to regulate BTB permeability.	btb	180-183	claudin 1	Homo sapiens	158-167
31296839-10	2019	Single or combined treatment of KHDRBS3, cDENND4C, and miR-577 effectively promoted antitumor drug doxorubicin (DOX) across BTB to induce apoptosis of glioma cells.	btb	124-127	KH RNA binding domain containing, signal transduction associated 3	Homo sapiens	32-39
31296839-10	2019	Single or combined treatment of KHDRBS3, cDENND4C, and miR-577 effectively promoted antitumor drug doxorubicin (DOX) across BTB to induce apoptosis of glioma cells.	btb	124-127	microRNA 577	Homo sapiens	55-62
31296839-11	2019	Collectively, the present study indicated that KHDRBS3 could regulate BTB permeability through the cDENND4C/miR-577 axis, which enhanced doxorubicin delivery across BTB.	btb	70-73	KH RNA binding domain containing, signal transduction associated 3	Homo sapiens	47-54
31296839-11	2019	Collectively, the present study indicated that KHDRBS3 could regulate BTB permeability through the cDENND4C/miR-577 axis, which enhanced doxorubicin delivery across BTB.	btb	70-73	microRNA 577	Homo sapiens	108-115
31296839-11	2019	Collectively, the present study indicated that KHDRBS3 could regulate BTB permeability through the cDENND4C/miR-577 axis, which enhanced doxorubicin delivery across BTB.	btb	165-168	KH RNA binding domain containing, signal transduction associated 3	Homo sapiens	47-54
31296839-11	2019	Collectively, the present study indicated that KHDRBS3 could regulate BTB permeability through the cDENND4C/miR-577 axis, which enhanced doxorubicin delivery across BTB.	btb	165-168	microRNA 577	Homo sapiens	108-115
30701278-4	2019	Recently, we found that yeast Whi2 (Saccharomyces cerevisiae) and a human counterpart, KCTD11, that shares a conserved BTB structural domain, are required to suppress TORC1 activity under low amino acid conditions.	btb	119-122	Whi2p	Saccharomyces cerevisiae S288C	30-34
30701278-4	2019	Recently, we found that yeast Whi2 (Saccharomyces cerevisiae) and a human counterpart, KCTD11, that shares a conserved BTB structural domain, are required to suppress TORC1 activity under low amino acid conditions.	btb	119-122	potassium channel tetramerization domain containing 11	Homo sapiens	87-93
30701278-4	2019	Recently, we found that yeast Whi2 (Saccharomyces cerevisiae) and a human counterpart, KCTD11, that shares a conserved BTB structural domain, are required to suppress TORC1 activity under low amino acid conditions.	btb	119-122	CREB regulated transcription coactivator 1	Homo sapiens	167-172
30777872-3	2019	We find that the highly conserved BTB corepressor binding site of BCL6 mediates stress adaptation across vertebrates.	btb	34-37	BCL6 transcription repressor	Homo sapiens	66-70
30142437-3	2019	A novel homozygous in-frame deletion was identified in exon 2 of KLHL7, affecting the BTB domain of the protein.	btb	86-89	kelch like family member 7	Homo sapiens	65-70
30814284-3	2019	One family of VACV proteins are the BTB-BACK (broad-complex, tram-trac, and bric-a-brac [BTB] and C-terminal Kelch [BACK]) domain-containing, Kelch-like (BBK) family of predicted cullin-3 E3 ligase adaptors: A55, C2, and F3.	btb	36-39	cullin 3	Homo sapiens	179-187
30024792-4	2019	In this study, we have identified that miR-132-3p is an essential miRNA by increasing the transcellular transport through the BTB.	btb	126-129	microRNA 1323	Homo sapiens	39-49
30905147-5	2019	The smaller size CNB1 has a deeper bowl depth ( d = 4.997 A) than CNB2 ( d = 3.682 A) and cannot undergo bowl-to-bowl (BTB) inversion below 373 K in toluene.	btb	119-122	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	17-21
30819806-4	2019	We report that the N-terminal BTB-BACK (BB) domain of A55 binds directly to the Cul3 N-terminal domain (Cul3-NTD), forming a 2:2 complex in solution.	btb	30-33	cullin 3	Homo sapiens	80-84
30819806-4	2019	We report that the N-terminal BTB-BACK (BB) domain of A55 binds directly to the Cul3 N-terminal domain (Cul3-NTD), forming a 2:2 complex in solution.	btb	30-33	cullin 3	Homo sapiens	104-108
30819806-4	2019	We report that the N-terminal BTB-BACK (BB) domain of A55 binds directly to the Cul3 N-terminal domain (Cul3-NTD), forming a 2:2 complex in solution.	btb	30-33	fuzzy planar cell polarity protein	Homo sapiens	109-112
30819806-5	2019	We solved the structure of an A55BB/Cul3-NTD complex from anisotropic crystals diffracting to 2.3/3.7 A resolution in the best/worst direction, revealing that the overall interaction and binding interface closely resemble the structures of cellular BTB/Cul3-NTD complexes, despite low sequence identity between A55 and cellular BTB domains.	btb	249-252	cullin 3	Homo sapiens	36-40
30819806-5	2019	We solved the structure of an A55BB/Cul3-NTD complex from anisotropic crystals diffracting to 2.3/3.7 A resolution in the best/worst direction, revealing that the overall interaction and binding interface closely resemble the structures of cellular BTB/Cul3-NTD complexes, despite low sequence identity between A55 and cellular BTB domains.	btb	249-252	fuzzy planar cell polarity protein	Homo sapiens	41-44
30024792-10	2019	In addition, miR132-3p+ significantly increased the delivery of doxorubicin across the BTB in vitro and contributed to the accumulation of doxorubicin within the brain tumor tissue.	btb	87-90	microRNA 132	Homo sapiens	13-19
29991775-9	2018	MiR-21 was found to directly target kelch repeat and BTB (POZ) domain containing 7 (KBTBD7), which promoted DAMP-triggered inflammatory responses in macrophages.	btb	53-56	microRNA 21a	Mus musculus	0-6
29322554-7	2018	Detection of transcripts of Collagen type2 A1 (Col2a1) revealed that both bTB and the anterior part of the hypophyseal cartilage developing anterior to the persistent epithelial stalk of the anterior lobe of the pituitary gland were suppressed in the Foxc1ch/ch .	btb	74-77	collagen, type II, alpha 1	Mus musculus	28-45
29322554-7	2018	Detection of transcripts of Collagen type2 A1 (Col2a1) revealed that both bTB and the anterior part of the hypophyseal cartilage developing anterior to the persistent epithelial stalk of the anterior lobe of the pituitary gland were suppressed in the Foxc1ch/ch .	btb	74-77	collagen, type II, alpha 1	Mus musculus	47-53
30006619-7	2018	S1P3 mediates its effects on BTB permeability through astrocytic secretion of IL-6 and CCL2, which relaxes endothelial cell adhesion.	btb	29-32	sphingosine-1-phosphate receptor 3	Homo sapiens	0-4
30006619-7	2018	S1P3 mediates its effects on BTB permeability through astrocytic secretion of IL-6 and CCL2, which relaxes endothelial cell adhesion.	btb	29-32	interleukin 6	Homo sapiens	78-82
30006619-7	2018	S1P3 mediates its effects on BTB permeability through astrocytic secretion of IL-6 and CCL2, which relaxes endothelial cell adhesion.	btb	29-32	C-C motif chemokine ligand 2	Homo sapiens	87-91
30006619-8	2018	Tumor cell overexpression of S1P3 mimics this pathway, enhancing IL-6 and CCL-2 production and elevating BTB permeability.	btb	105-108	sphingosine-1-phosphate receptor 3	Homo sapiens	29-33
30006619-9	2018	In conclusion, neuroinflammatory astrocytic S1P3 modulates BTB permeability.	btb	59-62	sphingosine-1-phosphate receptor 3	Homo sapiens	44-48
30680316-1	2019	HER2-targeted therapies effectively control systemic disease, but their efficacy against brain metastases is hindered by their low penetration of the blood-brain and blood-tumor barriers (BBB and BTB).	btb	196-199	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
30680316-2	2019	We investigate brain uptake and antitumor efficacy of transferrin receptor (TfR)-targeted, therapeutic nanoparticles designed to transcytose the BBB/BTB in three murine models.	btb	149-152	transferrin receptor	Mus musculus	54-74
30680316-2	2019	We investigate brain uptake and antitumor efficacy of transferrin receptor (TfR)-targeted, therapeutic nanoparticles designed to transcytose the BBB/BTB in three murine models.	btb	149-152	transferrin receptor	Mus musculus	76-79
30680316-6	2019	TfR-targeted nanoparticles accumulate and significantly delay growth in all three models, suggesting the IV model maintains a more intact BBB/BTB than the other models.	btb	142-145	transferrin receptor	Homo sapiens	0-3
29740849-4	2018	After 60 days of treatment, expressions of key apoptotic genes involved in both intrinsic and extrinsic pathways; solute carrier influx transporters SLCOB1, SLC22A1 and efflux transporter ABCB1 associated with transport of atorvastatin and nicotine, and proteins of BTB were assayed.	btb	266-269	ATP binding cassette subfamily B member 1A	Rattus norvegicus	188-193
30006619-6	2018	S1P3 inhibition functionally tightens the BTB in vitro and in vivo.	btb	42-45	sphingosine-1-phosphate receptor 3	Homo sapiens	0-4
29991775-9	2018	MiR-21 was found to directly target kelch repeat and BTB (POZ) domain containing 7 (KBTBD7), which promoted DAMP-triggered inflammatory responses in macrophages.	btb	53-56	kelch repeat and BTB (POZ) domain containing 7	Mus musculus	84-90
29673083-8	2018	These results demonstrate that PM2.5 restrained the expressions of BTB-associated proteins through activating TGF-beta3/p38 MAPK pathway and decreasing testosterone secretion, and therefore lead to the damage of BTB resulting in the decrease of sperm quality, which might be the potential reasons for its negative effects on spermatogenesis and male reproduction.	btb	67-70	transforming growth factor, beta 3	Rattus norvegicus	110-119
29743357-8	2018	We show that a single "humanizing" amino acid exchange in the BTB (broad-complex, tramtrack, and bric-a-brac)/POZ (poxvirus and zinc finger) domain is sufficient to fully rescue the antiviral activity of a shortened version of rhesus macaque 90K, but not that of the full-length protein.	btb	62-65	galectin 3 binding protein	Homo sapiens	242-245
29743357-9	2018	Comparison of the X-ray structures of the BTB/POZ domains of 90K from rhesus macaques and humans point toward a slightly larger hydrophobic patch at the surface of the rhesus macaque BTB domain that may modulate a direct interaction with either a second 90K domain or a different protein.IMPORTANCE The cellular 90K protein has been shown to diminish the infectivity of nascent HIV-1 particles.	btb	42-45	galectin 3 binding protein	Homo sapiens	61-64
29587386-4	2018	These SBUs are bridged by BTB ligands to yield a three-dimensional (3D) non-interpenetrated MOF as a result of the less effective packing due to the geometrically contrasting SBUs.	btb	26-29	lysine acetyltransferase 8	Homo sapiens	92-95
28929458-8	2018	Here we report near complete backbone 15N, 13C and 1H assignments for the BTB-POZ domain of BCL6 to assist in the analysis of binding modes for small molecules.	btb	74-77	BCL6 transcription repressor	Homo sapiens	92-96
29311822-4	2017	Pre-miR-330-3p markedly decreased the permeability of BTB and increased the expression of tight junction (TJ) related proteins ZO-1, occludin and claudin-5, however, anti-miR-330-3p had the opposite effects.	btb	54-57	microRNA 330	Homo sapiens	4-11
29499952-5	2018	In the present study, we demonstrated that the PIWIL1/piRNA-DQ593109 (piR-DQ593109) complex was the predominant regulator of BTB permeability.	btb	125-128	piwi like RNA-mediated gene silencing 1	Homo sapiens	47-53
29499952-8	2018	Downregulation of PIWIL1 or piR-DQ593109 increased the permeability of the BTB.	btb	75-78	piwi like RNA-mediated gene silencing 1	Homo sapiens	18-24
29499952-12	2018	In conclusion, downregulating PIWIL1 and piR-DQ593109 increased BTB permeability through the MEG3/miR-330-5p/RUNX3 axis.	btb	64-67	piwi like RNA-mediated gene silencing 1	Homo sapiens	30-36
29499952-12	2018	In conclusion, downregulating PIWIL1 and piR-DQ593109 increased BTB permeability through the MEG3/miR-330-5p/RUNX3 axis.	btb	64-67	maternally expressed 3	Homo sapiens	93-97
29499952-12	2018	In conclusion, downregulating PIWIL1 and piR-DQ593109 increased BTB permeability through the MEG3/miR-330-5p/RUNX3 axis.	btb	64-67	RUNX family transcription factor 3	Homo sapiens	109-114
28939920-1	2018	The best-studied Drosophila insulator complex consists of two BTB-containing proteins, the Mod(mdg4)-67.2 isoform and CP190, which are recruited cooperatively to chromatin through interactions with the DNA-binding architectural protein Su(Hw).	btb	62-65	modulo	Drosophila melanogaster	91-105
28939920-1	2018	The best-studied Drosophila insulator complex consists of two BTB-containing proteins, the Mod(mdg4)-67.2 isoform and CP190, which are recruited cooperatively to chromatin through interactions with the DNA-binding architectural protein Su(Hw).	btb	62-65	Centrosomal protein 190kD	Drosophila melanogaster	118-123
28939920-1	2018	The best-studied Drosophila insulator complex consists of two BTB-containing proteins, the Mod(mdg4)-67.2 isoform and CP190, which are recruited cooperatively to chromatin through interactions with the DNA-binding architectural protein Su(Hw).	btb	62-65	suppressor of Hairy wing	Drosophila melanogaster	236-242
29467620-1	2018	The blood-tumor barrier (BTB) hinders delivery of chemotherapeutic drugs to tumors in the brain; previous studies have shown that the BTB can be selectively opened by endothelial monocyte activating polypeptide-II (EMAP-II), but the specific mechanism involved remains elusive.	btb	25-28	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	167-213
29467620-1	2018	The blood-tumor barrier (BTB) hinders delivery of chemotherapeutic drugs to tumors in the brain; previous studies have shown that the BTB can be selectively opened by endothelial monocyte activating polypeptide-II (EMAP-II), but the specific mechanism involved remains elusive.	btb	25-28	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	215-222
29467620-1	2018	The blood-tumor barrier (BTB) hinders delivery of chemotherapeutic drugs to tumors in the brain; previous studies have shown that the BTB can be selectively opened by endothelial monocyte activating polypeptide-II (EMAP-II), but the specific mechanism involved remains elusive.	btb	134-137	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	167-213
29467620-1	2018	The blood-tumor barrier (BTB) hinders delivery of chemotherapeutic drugs to tumors in the brain; previous studies have shown that the BTB can be selectively opened by endothelial monocyte activating polypeptide-II (EMAP-II), but the specific mechanism involved remains elusive.	btb	134-137	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	215-222
29467620-5	2018	In in vitro BTB models, we also found that EMAP-II significantly increased BTB permeability, decreased expression of ZO-1, occludin and claudin-5 in GECs, in a time- and dose-dependent manner.	btb	12-15	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	43-50
29467620-5	2018	In in vitro BTB models, we also found that EMAP-II significantly increased BTB permeability, decreased expression of ZO-1, occludin and claudin-5 in GECs, in a time- and dose-dependent manner.	btb	75-78	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	43-50
29467620-6	2018	EMAP-II greatly increased miR-429 expression in GECs of the BTB models in vitro.	btb	60-63	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	0-7
29467620-6	2018	EMAP-II greatly increased miR-429 expression in GECs of the BTB models in vitro.	btb	60-63	microRNA 429	Homo sapiens	26-33
29467620-7	2018	Overexpression of miR-429 in GECs significantly decreased the transepithelial electric resistance (TEER) values in BTB models, and led to enhanced horseradish peroxidase (HRP) flux.	btb	115-118	microRNA 429	Homo sapiens	18-25
29467620-11	2018	The dual-luciferase reporter assay also showed that p70S6K was a target gene of miR-429; miR-429 overexpression down-regulated expression and phosphorylation levels of p70S6K, and also decreased phosphorylation levels of S6 and increased BTB permeability.	btb	238-241	ribosomal protein S6 kinase B1	Homo sapiens	52-58
29467620-11	2018	The dual-luciferase reporter assay also showed that p70S6K was a target gene of miR-429; miR-429 overexpression down-regulated expression and phosphorylation levels of p70S6K, and also decreased phosphorylation levels of S6 and increased BTB permeability.	btb	238-241	microRNA 429	Homo sapiens	80-87
29467620-11	2018	The dual-luciferase reporter assay also showed that p70S6K was a target gene of miR-429; miR-429 overexpression down-regulated expression and phosphorylation levels of p70S6K, and also decreased phosphorylation levels of S6 and increased BTB permeability.	btb	238-241	microRNA 429	Homo sapiens	89-96
29467620-11	2018	The dual-luciferase reporter assay also showed that p70S6K was a target gene of miR-429; miR-429 overexpression down-regulated expression and phosphorylation levels of p70S6K, and also decreased phosphorylation levels of S6 and increased BTB permeability.	btb	238-241	ribosomal protein S6 kinase B1	Homo sapiens	168-174
29467620-12	2018	Conversely, silencing of miR-429 increased the expression and phosphorylation levels of p70S6K, and increased phosphorylation levels of S6, while decreasing BTB permeability.	btb	157-160	microRNA 429	Homo sapiens	25-32
29311822-5	2017	Anti-miR-330-3p could enhance the effect of EMAP-II on increasing the permeability of BTB, however, pre-miR-330-3p partly reversed the effect of EMAP-II on that.	btb	86-89	microRNA 330	Homo sapiens	5-12
29311822-5	2017	Anti-miR-330-3p could enhance the effect of EMAP-II on increasing the permeability of BTB, however, pre-miR-330-3p partly reversed the effect of EMAP-II on that.	btb	86-89	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	44-51
29311822-5	2017	Anti-miR-330-3p could enhance the effect of EMAP-II on increasing the permeability of BTB, however, pre-miR-330-3p partly reversed the effect of EMAP-II on that.	btb	86-89	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	145-152
29311822-9	2017	These suggested that EMAP-II could increase the permeability of BTB through inhibiting miR-330-3p which target negative regulation of PKC-alpha.	btb	64-67	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	21-28
29311822-9	2017	These suggested that EMAP-II could increase the permeability of BTB through inhibiting miR-330-3p which target negative regulation of PKC-alpha.	btb	64-67	microRNA 330	Homo sapiens	87-94
29311822-9	2017	These suggested that EMAP-II could increase the permeability of BTB through inhibiting miR-330-3p which target negative regulation of PKC-alpha.	btb	64-67	protein kinase C alpha	Homo sapiens	134-143
29311822-10	2017	Pre-miR-330-3p and PKC-alpha inhibitor decreased the BTB permeability and up-regulated the expression levels of ZO-1, occludin and claudin-5 while anti-miR-330-3p and PKC-alpha activator brought the reverse effects.	btb	53-56	microRNA 330	Homo sapiens	4-11
29311822-10	2017	Pre-miR-330-3p and PKC-alpha inhibitor decreased the BTB permeability and up-regulated the expression levels of ZO-1, occludin and claudin-5 while anti-miR-330-3p and PKC-alpha activator brought the reverse effects.	btb	53-56	protein kinase C alpha	Homo sapiens	19-28
29311822-10	2017	Pre-miR-330-3p and PKC-alpha inhibitor decreased the BTB permeability and up-regulated the expression levels of ZO-1, occludin and claudin-5 while anti-miR-330-3p and PKC-alpha activator brought the reverse effects.	btb	53-56	claudin 5	Homo sapiens	131-140
29311822-10	2017	Pre-miR-330-3p and PKC-alpha inhibitor decreased the BTB permeability and up-regulated the expression levels of ZO-1, occludin and claudin-5 while anti-miR-330-3p and PKC-alpha activator brought the reverse effects.	btb	53-56	microRNA 330	Homo sapiens	152-159
29311822-11	2017	Compared with EMAP-II, anti-miR-330-3p and PKC-alpha activator alone, the combination of the three combinations significantly increased the BTB permeability.	btb	140-143	protein kinase C alpha	Homo sapiens	43-52
29311822-13	2017	Our studies suggest that low-dose EMAP-II up-regulates the expression of PKC-alpha and increases the activity of PKC-alpha by inhibiting the expression of miR-330-3p, reduces the expression of ZO-1, occludin and claudin-5, and thereby increasing the permeability of BTB.	btb	266-269	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	34-41
29311822-13	2017	Our studies suggest that low-dose EMAP-II up-regulates the expression of PKC-alpha and increases the activity of PKC-alpha by inhibiting the expression of miR-330-3p, reduces the expression of ZO-1, occludin and claudin-5, and thereby increasing the permeability of BTB.	btb	266-269	protein kinase C alpha	Homo sapiens	113-122
28438684-5	2017	They both contained a conserved BTB domain which was also found in D. melanogaster Fru isoforms.	btb	32-35	fruitless	Drosophila melanogaster	83-86
28963344-7	2017	SAXS data and structural modelling indicate that Cul3 may stabilize closed BTB pentamers by binding across their BTB-BTB interfaces.	btb	75-78	cullin 3	Homo sapiens	49-53
28963344-7	2017	SAXS data and structural modelling indicate that Cul3 may stabilize closed BTB pentamers by binding across their BTB-BTB interfaces.	btb	113-116	cullin 3	Homo sapiens	49-53
28963344-7	2017	SAXS data and structural modelling indicate that Cul3 may stabilize closed BTB pentamers by binding across their BTB-BTB interfaces.	btb	113-116	cullin 3	Homo sapiens	49-53
29021216-1	2017	The best-studied Drosophila insulator complex consists of two BTB-containing proteins, the Mod(mdg4)-67.2 isoform and CP190, which are recruited to the chromatin through interactions with the DNA-binding Su(Hw) protein.	btb	62-65	modulo	Drosophila melanogaster	91-105
29021216-1	2017	The best-studied Drosophila insulator complex consists of two BTB-containing proteins, the Mod(mdg4)-67.2 isoform and CP190, which are recruited to the chromatin through interactions with the DNA-binding Su(Hw) protein.	btb	62-65	Centrosomal protein 190kD	Drosophila melanogaster	118-123
29021216-7	2017	Finally, interaction between the BTB domain of Mod(mdg4)-67.2 and the M domain of CP190 has been demonstrated.	btb	33-36	modulo	Drosophila melanogaster	47-61
29021216-7	2017	Finally, interaction between the BTB domain of Mod(mdg4)-67.2 and the M domain of CP190 has been demonstrated.	btb	33-36	Centrosomal protein 190kD	Drosophila melanogaster	82-87
28818080-4	2017	RESULTS: The causative mutation was detected in the potassium channel tetramerization domain containing 1 (Kctd1) gene which leads to the amino acid exchange Kctd1 I27N thereby affecting the functional BTB domain of the protein.	btb	202-205	potassium channel tetramerisation domain containing 1	Mus musculus	107-112
28818080-4	2017	RESULTS: The causative mutation was detected in the potassium channel tetramerization domain containing 1 (Kctd1) gene which leads to the amino acid exchange Kctd1 I27N thereby affecting the functional BTB domain of the protein.	btb	202-205	potassium channel tetramerisation domain containing 1	Mus musculus	158-163
28701916-0	2017	The Role of HOTAIR/miR-148b-3p/USF1 on Regulating the Permeability of BTB.	btb	70-73	HOX transcript antisense RNA	Homo sapiens	12-18
28701916-0	2017	The Role of HOTAIR/miR-148b-3p/USF1 on Regulating the Permeability of BTB.	btb	70-73	microRNA 148b	Homo sapiens	19-27
28701916-0	2017	The Role of HOTAIR/miR-148b-3p/USF1 on Regulating the Permeability of BTB.	btb	70-73	upstream transcription factor 1	Homo sapiens	31-35
28701916-2	2017	The purposes of this study were to investigate the role and possible molecular mechanisms of HOTAIR in regulating the permeability of blood tumor barrier (BTB) in vitro.	btb	155-158	HOX transcript antisense RNA	Homo sapiens	93-99
28701916-4	2017	Knockdown of HOTAIR could increase the permeability of BTB as well as down-regulated the expressions of tight junction related proteins ZO-1, occludin, claudin-5, but up-regulated miR-148b-3p expressions in GECs.	btb	55-58	HOX transcript antisense RNA	Homo sapiens	13-19
28701916-4	2017	Knockdown of HOTAIR could increase the permeability of BTB as well as down-regulated the expressions of tight junction related proteins ZO-1, occludin, claudin-5, but up-regulated miR-148b-3p expressions in GECs.	btb	55-58	microRNA 148b	Homo sapiens	180-188
28701916-6	2017	Furthermore, overexpression of miR-148b-3p increased the permeability of BTB by down-regulating the expressions of tight junction related proteins and USF1 in GECs, and vice versa.	btb	73-76	microRNA 148b	Homo sapiens	31-39
28701916-6	2017	Furthermore, overexpression of miR-148b-3p increased the permeability of BTB by down-regulating the expressions of tight junction related proteins and USF1 in GECs, and vice versa.	btb	73-76	upstream transcription factor 1	Homo sapiens	151-155
28701916-8	2017	Silence of USF1 increased the permeability of BTB duo to their interaction with the promoters of ZO-1, occludin, and claudin-5 in GECs.	btb	46-49	upstream transcription factor 1	Homo sapiens	11-15
28701916-8	2017	Silence of USF1 increased the permeability of BTB duo to their interaction with the promoters of ZO-1, occludin, and claudin-5 in GECs.	btb	46-49	tight junction protein 1	Homo sapiens	97-101
28701916-8	2017	Silence of USF1 increased the permeability of BTB duo to their interaction with the promoters of ZO-1, occludin, and claudin-5 in GECs.	btb	46-49	occludin	Homo sapiens	103-111
28701916-8	2017	Silence of USF1 increased the permeability of BTB duo to their interaction with the promoters of ZO-1, occludin, and claudin-5 in GECs.	btb	46-49	claudin 5	Homo sapiens	117-126
28701916-9	2017	Taken together, our finding indicated that knockdown of HOTAIR increased BTB permeability via binding to miR-148b-3p, which further reducing tight junction related proteins in GECs by targeting USF1.	btb	73-76	HOX transcript antisense RNA	Homo sapiens	56-62
28701916-9	2017	Taken together, our finding indicated that knockdown of HOTAIR increased BTB permeability via binding to miR-148b-3p, which further reducing tight junction related proteins in GECs by targeting USF1.	btb	73-76	microRNA 148b	Homo sapiens	105-113
28701916-9	2017	Taken together, our finding indicated that knockdown of HOTAIR increased BTB permeability via binding to miR-148b-3p, which further reducing tight junction related proteins in GECs by targeting USF1.	btb	73-76	upstream transcription factor 1	Homo sapiens	194-198
29100012-7	2017	Inhibiting BMX with ibrutinib selectively targeted neoplastic pericytes and disrupted the BTB, but not the BBB, thereby increasing drug effusion into established tumors and enhancing the chemotherapeutic efficacy of drugs with poor BTB penetration.	btb	90-93	BMX non-receptor tyrosine kinase	Homo sapiens	11-14
29100012-7	2017	Inhibiting BMX with ibrutinib selectively targeted neoplastic pericytes and disrupted the BTB, but not the BBB, thereby increasing drug effusion into established tumors and enhancing the chemotherapeutic efficacy of drugs with poor BTB penetration.	btb	232-235	BMX non-receptor tyrosine kinase	Homo sapiens	11-14
28186440-7	2017	We report here the crystal structure of the complex of Britanin and the BTB domain of Keap1.	btb	72-75	kelch like ECH associated protein 1	Homo sapiens	86-91
28186440-10	2017	The complex crystal structure of Britanin and the BTB domain of Keap1 help clarify the mechanism of Nrf2 induction.	btb	50-53	kelch like ECH associated protein 1	Homo sapiens	64-69
28186440-10	2017	The complex crystal structure of Britanin and the BTB domain of Keap1 help clarify the mechanism of Nrf2 induction.	btb	50-53	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
28185956-4	2017	Here, we have identified lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1), was remarkably up-regulated in glioma endothelial cells (GECs) obtained from an in vitro BTB model.	btb	172-175	nuclear paraspeckle assembly transcript 1	Homo sapiens	75-80
28185956-5	2017	Knockdown of NEAT1 impaired the integrity and increased the permeability of the BTB, accompanied by downregulation of expression of the tight junction proteins ZO-1, occludin and claudin-5 in GECs.	btb	80-83	nuclear paraspeckle assembly transcript 1	Homo sapiens	13-18
28185956-6	2017	Both bioinformatics data and results of luciferase reporter assays demonstrated that NEAT1 influenced BTB permeability by binding to miR-181d-5p.	btb	102-105	nuclear paraspeckle assembly transcript 1	Homo sapiens	85-90
28185956-9	2017	In conclusion, knockdown of NEAT1 increased BTB permeability by binding to miR-181d-5p and then reducing tight junction protein expression by targeting SOX5.	btb	44-47	nuclear paraspeckle assembly transcript 1	Homo sapiens	28-33
28743001-3	2017	GCL, a conserved BTB (Broad-complex, Tramtrack, and Bric-a-brac) protein, is a substrate-specific adaptor for Cullin3-RING ubiquitin ligase complex (CRL3GCL).	btb	17-20	germ cell-less 2, spermatogenesis associated	Homo sapiens	0-3
28743001-3	2017	GCL, a conserved BTB (Broad-complex, Tramtrack, and Bric-a-brac) protein, is a substrate-specific adaptor for Cullin3-RING ubiquitin ligase complex (CRL3GCL).	btb	17-20	cullin 3	Homo sapiens	110-117
28287613-4	2017	The present study found that lncRNA X-inactive-specific transcript (XIST) was upregulated in endothelial cells that were obtained in a BTB model in vitro.	btb	135-138	X inactive specific transcript	Homo sapiens	36-66
28287613-4	2017	The present study found that lncRNA X-inactive-specific transcript (XIST) was upregulated in endothelial cells that were obtained in a BTB model in vitro.	btb	135-138	X inactive specific transcript	Homo sapiens	68-72
28287613-5	2017	XIST knockdown increased BTB permeability and inhibited glioma angiogenesis.	btb	25-28	X inactive specific transcript	Homo sapiens	0-4
28287613-8	2017	Overall, the present study demonstrates that XIST plays a pivotal role in BTB permeability and glioma angiogenesis, and the inhibition of XIST may be a potential target for the clinical management of glioma.	btb	74-77	X inactive specific transcript	Homo sapiens	45-49
27431008-10	2016	CONCLUSION: Borneol could selectively open the BTB and consequently increase BTB permeability, and this mechanism is associated with the down-regulation of ZO-1 and F-actin.	btb	77-80	tight junction protein 1	Rattus norvegicus	156-160
28280455-11	2017	This showed that the Ktrans value might be a non-invasive method to evaluate the BTB permeability in rat glioma after microbubble-enhanced ultrasound treatment.Western blot, qRT-PCR and immunohistochemical staining revealed that MEUS increased the KCa channels expression and reduced JAM-A expression in glioma.	btb	81-84	F11 receptor	Rattus norvegicus	284-289
28280455-14	2017	The mechanisms might involve the up-regulation of KCa channels expression and affecting the formation of tight junctions in the BTB by a reduction of JAM-A expression.	btb	128-131	F11 receptor	Rattus norvegicus	150-155
27431008-10	2016	CONCLUSION: Borneol could selectively open the BTB and consequently increase BTB permeability, and this mechanism is associated with the down-regulation of ZO-1 and F-actin.	btb	47-50	tight junction protein 1	Rattus norvegicus	156-160
27898696-7	2016	Through molecular modeling and yeast-two hybrid studies, we demonstrate that Rib and Lola homo- and heterodimerize via their BTB domains.	btb	125-128	ribbon	Drosophila melanogaster	77-80
27898696-7	2016	Through molecular modeling and yeast-two hybrid studies, we demonstrate that Rib and Lola homo- and heterodimerize via their BTB domains.	btb	125-128	longitudinals lacking	Drosophila melanogaster	85-89
27882115-4	2016	In total, 7 BTB were diagnosed, which constituted 1.08% (7/648) of all TB cases and 2.51% (7/278) of all NPTB cases.	btb	12-15	polypyrimidine tract binding protein 2	Homo sapiens	105-109
27486954-14	2016	We conclude that claudin-11 might represent the essential component of the BTB in human.	btb	75-78	claudin 11	Homo sapiens	17-27
26861687-8	2016	The mRNA and protein expression levels of caveolin-1 were identical with the changes of BTB permeability.	btb	88-91	caveolin 1	Homo sapiens	42-52
27220849-7	2016	We show that BTB-mediated SPOP dimers form linear oligomers via BACK domain dimerization, and we determine the concentration-dependent populations of the resulting oligomeric species.	btb	13-16	speckle type BTB/POZ protein	Homo sapiens	26-30
27131364-3	2016	Here, we report that functioning of SLX4 is dependent on its dimerization via an oligomerization motif called the BTB domain.	btb	114-117	SLX4 structure-specific endonuclease subunit	Homo sapiens	36-40
27131364-5	2016	Disruption of BTB dimerization abrogates nuclear foci formation and telomeric localization of not only SLX4 but also of its associated nucleases.	btb	14-17	SLX4 structure-specific endonuclease subunit	Homo sapiens	103-107
27131364-6	2016	Furthermore, dimerization-deficient SLX4 mutants cause defective cellular response to DNA interstrand crosslinking agent and telomere maintenance, underscoring the contribution of BTB domain-mediated dimerization of SLX4 in genome and telomere maintenance.	btb	180-183	SLX4 structure-specific endonuclease subunit	Homo sapiens	36-40
27131364-6	2016	Furthermore, dimerization-deficient SLX4 mutants cause defective cellular response to DNA interstrand crosslinking agent and telomere maintenance, underscoring the contribution of BTB domain-mediated dimerization of SLX4 in genome and telomere maintenance.	btb	180-183	SLX4 structure-specific endonuclease subunit	Homo sapiens	216-220
27152988-6	2016	Finally, negative-stain electron micrographs of KCTD6(BTB) in complex with Cullin3 show the presence of assemblies with a five-pointed pinwheel shape.	btb	54-57	potassium channel tetramerization domain containing 6	Homo sapiens	48-53
26521255-3	2016	This study further investigated the exact mechanisms by which the RhoA/ROCK signaling pathway affects EMAP-II-induced BTB hyperpermeability.	btb	118-121	ras homolog family member A	Rattus norvegicus	66-70
27152988-6	2016	Finally, negative-stain electron micrographs of KCTD6(BTB) in complex with Cullin3 show the presence of assemblies with a five-pointed pinwheel shape.	btb	54-57	cullin 3	Homo sapiens	75-82
26521255-8	2016	In summary, this study demonstrates that low-dose EMAP-II can increase BTB permeability by activating the RhoA/ROCK/PI3K signaling pathway.	btb	71-74	ras homolog family member A	Rattus norvegicus	106-110
27073627-5	2016	The results suggest that the IL-1beta-induced BTB permeability increase may be associated with the expression of caveolin-1 protein, and VEGF may be involved in this process.	btb	46-49	interleukin 1 beta	Rattus norvegicus	29-37
26879129-2	2016	Connexin 43, the best-studied GJ protein, is a component of the Sertoli cell barrier/blood-testis barrier (BTB).	btb	107-110	gap junction protein alpha 1	Homo sapiens	0-11
26879129-10	2016	In summary, IL1A regulates GJC in Sertoli cells, which is critical for BTB restructuring.	btb	71-74	interleukin 1 alpha	Homo sapiens	12-16
27073627-5	2016	The results suggest that the IL-1beta-induced BTB permeability increase may be associated with the expression of caveolin-1 protein, and VEGF may be involved in this process.	btb	46-49	caveolin 1	Rattus norvegicus	113-123
26619802-3	2016	Here, we elucidated the expression of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and defined its functional role in the regulation of BTB function as well as its possible molecular mechanisms.	btb	162-165	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	45-99
26903801-2	2016	Microarray analysis revealed 34 significantly deregulated miRNAs including miR-200b in the BTB as induced by RMP7 and 8 significantly up-regulated miRNAs in the BTB by RMP7.	btb	91-94	microRNA 200b	Homo sapiens	75-83
26903801-4	2016	Associated with this effect of RMP7 was a decrease in miR-200b expression within the human cerebral microvascular endothelial cells line hCMEC/D3 (ECs) of the BTB.	btb	159-162	microRNA 200b	Homo sapiens	54-62
26903801-7	2016	In addition, overexpression of miR-200b inhibited the relocation of occludin and claudin-5 from cellular borders into the cytoplasm as well as the production of stress fiber formation in GECs (ECs with U87 glioma cells co-culturing) of the BTB.	btb	240-243	microRNA 200b	Homo sapiens	31-39
26903801-9	2016	Overexpression of miR-200b was also associated with a down-regulation in RhoA and ROCKII expression, concomitant with a decrease in BTB permeability.	btb	132-135	microRNA 200b	Homo sapiens	18-26
26903801-11	2016	We further found that miR-200b regulated BTB permeability by directly targeting RhoA and ROCKII.	btb	41-44	microRNA 200b	Homo sapiens	22-30
26903801-11	2016	We further found that miR-200b regulated BTB permeability by directly targeting RhoA and ROCKII.	btb	41-44	ras homolog family member A	Homo sapiens	80-84
26903801-12	2016	Collectively, these results suggest that miR-200b"s contribution to the RMP7-induced increase in BTB permeability was associated with stress fiber formation and TJ disassembly as achieved by directly targeting RhoA and ROCKII.	btb	97-100	microRNA 200b	Homo sapiens	41-49
26903801-12	2016	Collectively, these results suggest that miR-200b"s contribution to the RMP7-induced increase in BTB permeability was associated with stress fiber formation and TJ disassembly as achieved by directly targeting RhoA and ROCKII.	btb	97-100	ras homolog family member A	Homo sapiens	210-214
26619802-3	2016	Here, we elucidated the expression of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and defined its functional role in the regulation of BTB function as well as its possible molecular mechanisms.	btb	162-165	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	101-107
26619802-5	2016	Functionally, knockdown of MALAT1 resulted in an impairment and increased the permeability of BTB as well as decreased the expression of ZO-1, occludin and claudin-5 in GECs.	btb	94-97	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	27-33
26619802-7	2016	Mechanistic investigations defined that nuclear factor YA (NFYA), a CCAAT box-binding transcription factor, was a direct and functional downstream target of miR-140, which was involved in the MALAT1 knockdown induced regulation of BTB function.	btb	231-234	nuclear transcription factor Y subunit alpha	Homo sapiens	59-63
26619802-7	2016	Mechanistic investigations defined that nuclear factor YA (NFYA), a CCAAT box-binding transcription factor, was a direct and functional downstream target of miR-140, which was involved in the MALAT1 knockdown induced regulation of BTB function.	btb	231-234	microRNA 140	Homo sapiens	157-164
26619802-7	2016	Mechanistic investigations defined that nuclear factor YA (NFYA), a CCAAT box-binding transcription factor, was a direct and functional downstream target of miR-140, which was involved in the MALAT1 knockdown induced regulation of BTB function.	btb	231-234	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	192-198
26619802-9	2016	Taken together, we have demonstrated the fact that knockdown of MALAT1 resulted in the increased permeability of BTB, which might contribute to establishing potential therapeutic strategies for human gliomas.	btb	113-116	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	64-70
26358039-9	2016	In conclusion, this study demonstrates that low-dose EMAP-II induces BTB hyperpermeability via the cAMP/PKA/Rac1 signaling pathway.	btb	69-72	Rac family small GTPase 1	Rattus norvegicus	108-112
26334369-7	2016	Finally, we confirm the 5:5 assembly of KCTD9/Cul3 complexes by cryo-electron microscopy and provide a molecular rationale for BTB-mediated Cul3 binding specificity in the KCTD family.	btb	127-130	potassium channel tetramerization domain containing 9	Homo sapiens	40-45
26334369-7	2016	Finally, we confirm the 5:5 assembly of KCTD9/Cul3 complexes by cryo-electron microscopy and provide a molecular rationale for BTB-mediated Cul3 binding specificity in the KCTD family.	btb	127-130	cullin 3	Homo sapiens	46-50
26334369-7	2016	Finally, we confirm the 5:5 assembly of KCTD9/Cul3 complexes by cryo-electron microscopy and provide a molecular rationale for BTB-mediated Cul3 binding specificity in the KCTD family.	btb	127-130	cullin 3	Homo sapiens	140-144
26649574-7	2015	We present the 2.5 A resolution structure of the CP190 N-terminal 126 amino acids, which adopts a canonical BTB domain fold and exists as a stable dimer in solution.	btb	108-111	Centrosomal protein 190kD	Drosophila melanogaster	49-54
26356851-2	2015	This study investigates the potential effects of miR-18a on the permeability of the blood-tumor barrier (BTB) and its possible molecular mechanisms.	btb	105-108	microRNA 18a	Homo sapiens	49-56
26356851-4	2015	The endogenous expression of miR-18a in glioma vascular endothelial cells (GECs) was significantly lower than that in normal vascular ECs, and the overexpression of miR-18a significantly increased the permeability of the BTB as well as downregulating the mRNA and protein expressions of tight junction-related proteins zonula occluden-1 (ZO-1), claudin-5, and occludin in GECs.	btb	221-224	microRNA 18a	Homo sapiens	29-36
26356851-4	2015	The endogenous expression of miR-18a in glioma vascular endothelial cells (GECs) was significantly lower than that in normal vascular ECs, and the overexpression of miR-18a significantly increased the permeability of the BTB as well as downregulating the mRNA and protein expressions of tight junction-related proteins zonula occluden-1 (ZO-1), claudin-5, and occludin in GECs.	btb	221-224	microRNA 18a	Homo sapiens	165-172
26356851-8	2015	This study shows that miR-18a targets and negatively regulates MEF2D, which further regulates tight junction-related proteins ZO-1, claudin-5, and occludin through transactivation of KLF4 and, finally, changes the permeability of the BTB.	btb	234-237	microRNA 18a	Homo sapiens	22-29
26356851-8	2015	This study shows that miR-18a targets and negatively regulates MEF2D, which further regulates tight junction-related proteins ZO-1, claudin-5, and occludin through transactivation of KLF4 and, finally, changes the permeability of the BTB.	btb	234-237	myocyte enhancer factor 2D	Homo sapiens	63-68
26356851-8	2015	This study shows that miR-18a targets and negatively regulates MEF2D, which further regulates tight junction-related proteins ZO-1, claudin-5, and occludin through transactivation of KLF4 and, finally, changes the permeability of the BTB.	btb	234-237	tight junction protein 1	Homo sapiens	126-130
26356851-8	2015	This study shows that miR-18a targets and negatively regulates MEF2D, which further regulates tight junction-related proteins ZO-1, claudin-5, and occludin through transactivation of KLF4 and, finally, changes the permeability of the BTB.	btb	234-237	claudin 5	Homo sapiens	132-141
26356851-8	2015	This study shows that miR-18a targets and negatively regulates MEF2D, which further regulates tight junction-related proteins ZO-1, claudin-5, and occludin through transactivation of KLF4 and, finally, changes the permeability of the BTB.	btb	234-237	occludin	Homo sapiens	147-155
26356851-8	2015	This study shows that miR-18a targets and negatively regulates MEF2D, which further regulates tight junction-related proteins ZO-1, claudin-5, and occludin through transactivation of KLF4 and, finally, changes the permeability of the BTB.	btb	234-237	Kruppel like factor 4	Homo sapiens	183-187
26356851-9	2015	MiR-18a should garner growing attention because it might serve as a potential target in opening the BTB and providing a new strategy for the treatment of gliomas.	btb	100-103	microRNA 18a	Homo sapiens	0-7
26489095-3	2015	Different isoforms of the BTB-containing protein Mod(mdg4) interact with Su(Hw) and dCTCF.	btb	26-29	modifier of mdg4	Drosophila melanogaster	49-57
26537751-4	2015	Here we demonstrated that Slc15a1, a peptide transporter also known as Pept1, was predominantly present in peritubular myoid cells, interstitial Leydig cells, vascular endothelial cells and germ cells, while absent in Sertoli cells or BTB site.	btb	235-238	solute carrier family 15 member 1	Rattus norvegicus	26-33
26537751-4	2015	Here we demonstrated that Slc15a1, a peptide transporter also known as Pept1, was predominantly present in peritubular myoid cells, interstitial Leydig cells, vascular endothelial cells and germ cells, while absent in Sertoli cells or BTB site.	btb	235-238	solute carrier family 15 member 1	Rattus norvegicus	71-76
26489095-3	2015	Different isoforms of the BTB-containing protein Mod(mdg4) interact with Su(Hw) and dCTCF.	btb	26-29	CTCF	Drosophila melanogaster	84-89
26722502-3	2015	In the present work, we studied the regulative effect of caveolin-1 on the expression of tight junction-associated proteins and BTB via directly silencing and overexpressing of caveolin-1 by recombinant adenovirus transduction of glioma-derived microvascular endothelial cells in rat brain.	btb	128-131	caveolin 1	Rattus norvegicus	57-67
26722502-4	2015	The results show that the caveolin-1 downregulation resulted in decreased expression of tight junction-associated proteins, opening of tight junctions, and increasing the permeability of BTB, whereas the overexpression of caveolin-1 presented the opposite effects.	btb	187-190	caveolin 1	Rattus norvegicus	26-36
26722502-5	2015	Therefore, we conclude that caveolin-1 regulates the expression of tight junction-associated proteins in a positive manner, which further plays a role in the regulation of BTB permeability.	btb	172-175	caveolin 1	Rattus norvegicus	28-38
25619834-4	2015	Interestingly, KLHL39 does not bind Cul3 because of the absence of certain conserved residues in the BTB domain.	btb	101-104	influenza virus NS1A binding protein	Homo sapiens	15-21
26078353-6	2015	Knockdown of TUG1 increased BTB permeability, and meanwhile down-regulated the expression of the tight junction proteins ZO-1, occludin, and claudin-5.	btb	28-31	taurine up-regulated 1	Homo sapiens	13-17
26165742-5	2015	We found the expression levels of BTB factors (Connexin43, ZO-1, Vimentin, Claudin1, Claudin5) were disrupted in TM-4 cells after HS treatment, which were recovered by the addition of carnitine.	btb	34-37	gap junction protein, alpha 1	Mus musculus	47-57
26165742-5	2015	We found the expression levels of BTB factors (Connexin43, ZO-1, Vimentin, Claudin1, Claudin5) were disrupted in TM-4 cells after HS treatment, which were recovered by the addition of carnitine.	btb	34-37	tight junction protein 1	Mus musculus	59-63
26165742-5	2015	We found the expression levels of BTB factors (Connexin43, ZO-1, Vimentin, Claudin1, Claudin5) were disrupted in TM-4 cells after HS treatment, which were recovered by the addition of carnitine.	btb	34-37	vimentin	Mus musculus	65-73
26165742-5	2015	We found the expression levels of BTB factors (Connexin43, ZO-1, Vimentin, Claudin1, Claudin5) were disrupted in TM-4 cells after HS treatment, which were recovered by the addition of carnitine.	btb	34-37	claudin 1	Mus musculus	75-83
26165742-5	2015	We found the expression levels of BTB factors (Connexin43, ZO-1, Vimentin, Claudin1, Claudin5) were disrupted in TM-4 cells after HS treatment, which were recovered by the addition of carnitine.	btb	34-37	claudin 5	Mus musculus	85-93
26044663-9	2015	This study demonstrates that the cAMP/Epac/Rap1 signaling cascade is a crucial pathway in EMAP-II-induced BTB hyperpermeability.	btb	106-109	Rap guanine nucleotide exchange factor 3	Homo sapiens	38-42
26044663-9	2015	This study demonstrates that the cAMP/Epac/Rap1 signaling cascade is a crucial pathway in EMAP-II-induced BTB hyperpermeability.	btb	106-109	RAP1A, member of RAS oncogene family	Homo sapiens	43-47
26044663-9	2015	This study demonstrates that the cAMP/Epac/Rap1 signaling cascade is a crucial pathway in EMAP-II-induced BTB hyperpermeability.	btb	106-109	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	90-97
26087743-14	2015	Collectively, this study demonstrates that low-dose EMAP-II increases BTB permeability via a RhoA/Rho kinase/PKC-alpha/beta/PP1 signaling pathway and that PP1/PP2A-mediated Ser/Thr dephosphorylation of occludin plays an important role in EMAP-II-induced BTB hyperpermeability.	btb	70-73	ras homolog family member A	Rattus norvegicus	93-97
26087743-14	2015	Collectively, this study demonstrates that low-dose EMAP-II increases BTB permeability via a RhoA/Rho kinase/PKC-alpha/beta/PP1 signaling pathway and that PP1/PP2A-mediated Ser/Thr dephosphorylation of occludin plays an important role in EMAP-II-induced BTB hyperpermeability.	btb	70-73	protein kinase C, alpha	Rattus norvegicus	109-118
26087743-14	2015	Collectively, this study demonstrates that low-dose EMAP-II increases BTB permeability via a RhoA/Rho kinase/PKC-alpha/beta/PP1 signaling pathway and that PP1/PP2A-mediated Ser/Thr dephosphorylation of occludin plays an important role in EMAP-II-induced BTB hyperpermeability.	btb	70-73	neuropeptide Y receptor Y4	Rattus norvegicus	124-127
26087743-14	2015	Collectively, this study demonstrates that low-dose EMAP-II increases BTB permeability via a RhoA/Rho kinase/PKC-alpha/beta/PP1 signaling pathway and that PP1/PP2A-mediated Ser/Thr dephosphorylation of occludin plays an important role in EMAP-II-induced BTB hyperpermeability.	btb	254-257	neuropeptide Y receptor Y4	Rattus norvegicus	155-158
26106824-0	2015	Bradykinin increased the permeability of BTB via NOS/NO/ZONAB-mediating down-regulation of claudin-5 and occludin.	btb	41-44	kininogen 1	Homo sapiens	0-10
26106824-0	2015	Bradykinin increased the permeability of BTB via NOS/NO/ZONAB-mediating down-regulation of claudin-5 and occludin.	btb	41-44	Y-box binding protein 3	Homo sapiens	56-61
26106824-0	2015	Bradykinin increased the permeability of BTB via NOS/NO/ZONAB-mediating down-regulation of claudin-5 and occludin.	btb	41-44	claudin 5	Homo sapiens	91-100
26106824-0	2015	Bradykinin increased the permeability of BTB via NOS/NO/ZONAB-mediating down-regulation of claudin-5 and occludin.	btb	41-44	occludin	Homo sapiens	105-113
26106824-2	2015	NOS inhibitors l-NAME and 7-NI could effectively block the effect of BK on increasing BTB permeability, decreasing the expressions of claudin-5 and occludin and promoting the translocation of ZONAB.	btb	86-89	kininogen 1	Homo sapiens	69-71
26106824-3	2015	Overexpression of ZONAB could significantly enhance BK-mediating BTB permeability.	btb	65-68	Y-box binding protein 3	Homo sapiens	18-23
26106824-3	2015	Overexpression of ZONAB could significantly enhance BK-mediating BTB permeability.	btb	65-68	kininogen 1	Homo sapiens	52-54
26106824-5	2015	This study indicated NOS/NO/ZONAB pathway might be involved in BK"s increasing the permeability of BTB.	btb	99-102	Y-box binding protein 3	Homo sapiens	28-33
26106824-5	2015	This study indicated NOS/NO/ZONAB pathway might be involved in BK"s increasing the permeability of BTB.	btb	99-102	kininogen 1	Homo sapiens	63-65
26044663-2	2015	In a recent study, we revealed that cAMP/PKA-dependent and cAMP/PKA-independent signaling pathways are both involved in EMAP-II-induced BTB hyperpermeability.	btb	136-139	cathelicidin antimicrobial peptide	Homo sapiens	36-63
26044663-2	2015	In a recent study, we revealed that cAMP/PKA-dependent and cAMP/PKA-independent signaling pathways are both involved in EMAP-II-induced BTB hyperpermeability.	btb	136-139	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	120-127
26044663-3	2015	The present study further investigated the exact mechanisms through which the cAMP/PKA-independent signaling pathway affects EMAP-II-induced BTB hyperpermeability.	btb	141-144	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	125-132
26044663-4	2015	In an in vitro BTB model, low-dose EMAP-II (0.05 nM) induced a significant decrease in Rap1 activity in RBMECs.	btb	15-18	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	35-42
26188516-1	2015	Based on its specific interaction with cullin3 mediated by an N-terminal BTB/POZ homologous domain, KCTD5 has been proposed to function as substrate adapter for cullin3 based ubiquitin E3 ligases.	btb	73-76	cullin 3	Homo sapiens	39-46
26188516-1	2015	Based on its specific interaction with cullin3 mediated by an N-terminal BTB/POZ homologous domain, KCTD5 has been proposed to function as substrate adapter for cullin3 based ubiquitin E3 ligases.	btb	73-76	potassium channel tetramerization domain containing 5	Homo sapiens	100-105
26188516-1	2015	Based on its specific interaction with cullin3 mediated by an N-terminal BTB/POZ homologous domain, KCTD5 has been proposed to function as substrate adapter for cullin3 based ubiquitin E3 ligases.	btb	73-76	cullin 3	Homo sapiens	161-168
26078353-7	2015	Both bioinformatics and luciferase reporter assays demonstrated that TUG1 influenced BTB permeability via binding to miR-144.	btb	85-88	taurine up-regulated 1	Homo sapiens	69-73
26078353-7	2015	Both bioinformatics and luciferase reporter assays demonstrated that TUG1 influenced BTB permeability via binding to miR-144.	btb	85-88	microRNA 144	Homo sapiens	117-124
26078353-10	2015	In conclusion, our results indicate that knockdown of TUG1 increased BTB permeability via binding to miR-144 and then reducing EC tight junction protein expression by targeting HSF2.	btb	69-72	taurine up-regulated 1	Homo sapiens	54-58
26078353-10	2015	In conclusion, our results indicate that knockdown of TUG1 increased BTB permeability via binding to miR-144 and then reducing EC tight junction protein expression by targeting HSF2.	btb	69-72	microRNA 144	Homo sapiens	101-108
26078353-11	2015	Thus, TUG1 may represent a useful future therapeutic target for enhancing BTB permeability.	btb	74-77	taurine up-regulated 1	Homo sapiens	6-10
26243517-4	2015	Building upon this finding, we report here that CIITA interacted with HIC1 via the GTP-binding domain (GBD) while HIC1 interacted with CIITA via the BTB/POZ domain.	btb	149-152	HIC ZBTB transcriptional repressor 1	Homo sapiens	114-118
26248466-7	2015	The CP190 interaction module encompasses a sequence ~200 amino acids long that spans the C-terminal and mediates interactions with the N-terminal BTB domain of the CP190 protein.	btb	146-149	Centrosomal protein 190kD	Drosophila melanogaster	4-9
26248466-7	2015	The CP190 interaction module encompasses a sequence ~200 amino acids long that spans the C-terminal and mediates interactions with the N-terminal BTB domain of the CP190 protein.	btb	146-149	Centrosomal protein 190kD	Drosophila melanogaster	164-169
26047759-0	2015	Targeting microbubbles-carrying TGFbeta1 inhibitor combined with ultrasound sonication induce BBB/BTB disruption to enhance nanomedicine treatment for brain tumors.	btb	98-101	transforming growth factor, beta 1	Mus musculus	32-40
26047759-2	2015	In this study, we developed des-octanoyl ghrelin-conjugated microbubbles (GMB) loaded with TGFbeta1 inhibitor (LY364947) (GMBL) to induce BBB/BTB disruption for ultrasound (US) sonication with GMBL.	btb	142-145	ghrelin	Mus musculus	41-48
26047759-2	2015	In this study, we developed des-octanoyl ghrelin-conjugated microbubbles (GMB) loaded with TGFbeta1 inhibitor (LY364947) (GMBL) to induce BBB/BTB disruption for ultrasound (US) sonication with GMBL.	btb	142-145	transforming growth factor, beta 1	Mus musculus	91-99
25891951-4	2015	Amino acid substitution in the SIM sequence (SIM/M) within the BTB/POZ domain partially reduced K167 SUMOylation activity of NACC1.	btb	63-66	nucleus accumbens associated 1	Homo sapiens	125-130
25891951-8	2015	A pull-down assay revealed that the consensus motifs of the SUMO acceptor site at K167 and the SIM within the BTB/POZ domain were both necessary for efficient binding to PML protein.	btb	110-113	PML nuclear body scaffold	Homo sapiens	170-173
24743033-5	2014	Pep-1, one specific ligand of IL-13Ralpha2, was identified to exhibit excellent capacity of crossing the blood tumor barrier (BTB) and homing to giloma.	btb	126-129	neuronal vesicle trafficking associated 1	Rattus norvegicus	0-5
25788289-3	2015	In this study, we show that miR-34a overexpression leads to significantly increased permeability of BTB, whereas miR-34a silencing reduces the permeability of the BTB.	btb	163-166	microRNA 34a	Homo sapiens	113-120
25788289-6	2015	We also show that cotransfection of miR-34a and PKCepsilon inversely coregulates BTB permeability and protein expression levels of tight junction-related proteins.	btb	81-84	microRNA 34a	Homo sapiens	36-43
25788289-6	2015	We also show that cotransfection of miR-34a and PKCepsilon inversely coregulates BTB permeability and protein expression levels of tight junction-related proteins.	btb	81-84	protein kinase C epsilon	Homo sapiens	48-58
25788289-7	2015	Pretreatment of psiepsilonRACK, a PKCepsilon-specific activator, decreases BTB permeability in miR-34a-overexpressed GECs and up-regulates expression levels of tight junction proteins.	btb	75-78	protein kinase C epsilon	Homo sapiens	34-44
25788289-7	2015	Pretreatment of psiepsilonRACK, a PKCepsilon-specific activator, decreases BTB permeability in miR-34a-overexpressed GECs and up-regulates expression levels of tight junction proteins.	btb	75-78	microRNA 34a	Homo sapiens	95-102
25788289-9	2015	Collectively, our findings indicate that miR-34a regulates BTB function by targeting PKCepsilon; after phosphorylation, PKCepsilon is activated and contributes to regulation of the expression of tight junction-related proteins, ultimately altering BTB permeability.	btb	59-62	microRNA 34a	Homo sapiens	41-48
25788289-9	2015	Collectively, our findings indicate that miR-34a regulates BTB function by targeting PKCepsilon; after phosphorylation, PKCepsilon is activated and contributes to regulation of the expression of tight junction-related proteins, ultimately altering BTB permeability.	btb	59-62	protein kinase C epsilon	Homo sapiens	85-95
25788289-9	2015	Collectively, our findings indicate that miR-34a regulates BTB function by targeting PKCepsilon; after phosphorylation, PKCepsilon is activated and contributes to regulation of the expression of tight junction-related proteins, ultimately altering BTB permeability.	btb	59-62	protein kinase C epsilon	Homo sapiens	120-130
25788289-9	2015	Collectively, our findings indicate that miR-34a regulates BTB function by targeting PKCepsilon; after phosphorylation, PKCepsilon is activated and contributes to regulation of the expression of tight junction-related proteins, ultimately altering BTB permeability.	btb	248-251	microRNA 34a	Homo sapiens	41-48
25788289-9	2015	Collectively, our findings indicate that miR-34a regulates BTB function by targeting PKCepsilon; after phosphorylation, PKCepsilon is activated and contributes to regulation of the expression of tight junction-related proteins, ultimately altering BTB permeability.	btb	248-251	protein kinase C epsilon	Homo sapiens	120-130
25416651-8	2015	In summary, our present study demonstrates that the cAMP/PKA signaling cascade works as a crucial signaling pathway in EMAP-II-induced BTB hyperpermeability.	btb	135-138	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	57-60
25402598-8	2015	In vitro analysis of a panel of Kif18A-related kinesins revealed that the two most potent compounds show improved selectivity compared to BTB-1.	btb	138-141	kinesin family member 18A	Homo sapiens	32-38
25452107-0	2015	MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5.	btb	38-41	microRNA 18a	Homo sapiens	0-7
25452107-0	2015	MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5.	btb	38-41	RUNX family transcription factor 1	Homo sapiens	46-51
25452107-0	2015	MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5.	btb	38-41	tight junction protein 1	Homo sapiens	80-84
25452107-0	2015	MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5.	btb	38-41	occludin	Homo sapiens	86-94
25452107-0	2015	MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5.	btb	38-41	claudin 5	Homo sapiens	99-108
25452107-4	2015	The overexpression of miR-18a significantly impaired the integrity and increased the permeability of BTB, which respectively were detected by TEER and HRP flux assays, accompanied by down-regulated mRNA and protein expressions and distributions of ZO-1, occludin and claudin-5 in GECs.	btb	101-104	microRNA 18a	Homo sapiens	22-29
25452107-4	2015	The overexpression of miR-18a significantly impaired the integrity and increased the permeability of BTB, which respectively were detected by TEER and HRP flux assays, accompanied by down-regulated mRNA and protein expressions and distributions of ZO-1, occludin and claudin-5 in GECs.	btb	101-104	tight junction protein 1	Homo sapiens	248-252
25452107-4	2015	The overexpression of miR-18a significantly impaired the integrity and increased the permeability of BTB, which respectively were detected by TEER and HRP flux assays, accompanied by down-regulated mRNA and protein expressions and distributions of ZO-1, occludin and claudin-5 in GECs.	btb	101-104	occludin	Homo sapiens	254-262
25452107-4	2015	The overexpression of miR-18a significantly impaired the integrity and increased the permeability of BTB, which respectively were detected by TEER and HRP flux assays, accompanied by down-regulated mRNA and protein expressions and distributions of ZO-1, occludin and claudin-5 in GECs.	btb	101-104	claudin 5	Homo sapiens	267-276
25452107-7	2015	Most important, miR-18a and RUNX1 could reversely regulate the permeability of BTB as well as the expressions and distributions of ZO-1, occludin and claudin-5.	btb	79-82	microRNA 18a	Homo sapiens	16-23
25452107-7	2015	Most important, miR-18a and RUNX1 could reversely regulate the permeability of BTB as well as the expressions and distributions of ZO-1, occludin and claudin-5.	btb	79-82	RUNX family transcription factor 1	Homo sapiens	28-33
25470344-2	2015	We found that the endothelial cell (EC) receptor molecule Roundabout 4 (Robo4) is endogenously expressed in human brain microvascular ECs and that it is upregulated in a BTB model of glioma cocultured ECs.	btb	170-173	roundabout guidance receptor 4	Homo sapiens	58-70
25470344-2	2015	We found that the endothelial cell (EC) receptor molecule Roundabout 4 (Robo4) is endogenously expressed in human brain microvascular ECs and that it is upregulated in a BTB model of glioma cocultured ECs.	btb	170-173	roundabout guidance receptor 4	Homo sapiens	72-77
25470344-3	2015	Knockdown of Robo4 in this BTB model increased permeability; short hairpin RNA targeting Robo4 (shRobo4) led to decreased transendothelial electric resistance values, increased BTB permeability, and downregulated expression of the EC tight junction proteins ZO-1, occludin, and claudin-5.	btb	27-30	roundabout guidance receptor 4	Homo sapiens	13-18
25470344-3	2015	Knockdown of Robo4 in this BTB model increased permeability; short hairpin RNA targeting Robo4 (shRobo4) led to decreased transendothelial electric resistance values, increased BTB permeability, and downregulated expression of the EC tight junction proteins ZO-1, occludin, and claudin-5.	btb	177-180	roundabout guidance receptor 4	Homo sapiens	89-94
25470344-4	2015	Roundabout 4 influenced BTB permeability via binding with its ligand, Slit2.	btb	24-27	roundabout guidance receptor 4	Homo sapiens	0-12
25470344-4	2015	Roundabout 4 influenced BTB permeability via binding with its ligand, Slit2.	btb	24-27	slit guidance ligand 2	Homo sapiens	70-75
25470344-7	2015	Together, our results indicate that knockdown of Robo4 increased BTB permeability by reducing EC tight junction protein expression, and that the Src-Erk1/2-MMP-9 signal pathways are involved in this process.	btb	65-68	roundabout guidance receptor 4	Homo sapiens	49-54
25470344-8	2015	Thus, Robo4 may represent a useful future therapeutic target for enhancing BTB permeability.	btb	75-78	roundabout guidance receptor 4	Homo sapiens	6-11
25107461-8	2014	Induction of miR155 expression in cattle sourced from farms with confirmed bTB that tested positive in the tuberculin skin or interferon-gamma blood test was found to be significantly higher in cattle presenting with more advanced pathology (defined by the presence of visible TB lesions) compared to infected cattle without visible pathology and thus likely to be of lower infectivity than those with more advanced disease.	btb	75-78	microRNA 155	Bos taurus	13-19
24641180-12	2014	In addition, BTB rescued defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost.	btb	13-16	ATP synthase inhibitory factor subunit 1a	Danio rerio	120-127
25957170-5	2015	In this article, we demonstrate, using a mutant form of Bcl6 with two BTB (bric-a-brac, tramtrack, broad-complex) mutations that abrogate corepressor binding, that the Bcl6 BTB domain is required for proper differentiation of Tfh and GC-Tfh cells in vivo.	btb	70-73	BCL6 transcription repressor	Homo sapiens	56-60
25957170-5	2015	In this article, we demonstrate, using a mutant form of Bcl6 with two BTB (bric-a-brac, tramtrack, broad-complex) mutations that abrogate corepressor binding, that the Bcl6 BTB domain is required for proper differentiation of Tfh and GC-Tfh cells in vivo.	btb	70-73	BCL6 transcription repressor	Homo sapiens	168-172
25788289-3	2015	In this study, we show that miR-34a overexpression leads to significantly increased permeability of BTB, whereas miR-34a silencing reduces the permeability of the BTB.	btb	100-103	microRNA 34a	Homo sapiens	28-35
25848797-1	2015	Cullin3 (Cul3), a key factor of protein ubiquitination, is able to interact with dozens of different proteins containing a BTB (Bric-a-brac, Tramtrack and Broad Complex) domain.	btb	123-126	cullin 3	Homo sapiens	0-7
25848797-1	2015	Cullin3 (Cul3), a key factor of protein ubiquitination, is able to interact with dozens of different proteins containing a BTB (Bric-a-brac, Tramtrack and Broad Complex) domain.	btb	123-126	cullin 3	Homo sapiens	9-13
25848797-5	2015	We also show that some of these peptides were able to bind to the BTB of the tetrameric KCTD11, a substrate adaptor involved in HDAC1 degradation, with high affinity (~ 300-600 nM).	btb	66-69	potassium channel tetramerization domain containing 11	Homo sapiens	88-94
25848797-5	2015	We also show that some of these peptides were able to bind to the BTB of the tetrameric KCTD11, a substrate adaptor involved in HDAC1 degradation, with high affinity (~ 300-600 nM).	btb	66-69	histone deacetylase 1	Homo sapiens	128-133
25848797-6	2015	Cul3-derived staple peptides are also able to bind the BTB of the pentameric KCTD5.	btb	55-58	cullin 3	Homo sapiens	0-4
25848797-6	2015	Cul3-derived staple peptides are also able to bind the BTB of the pentameric KCTD5.	btb	55-58	potassium channel tetramerization domain containing 5	Homo sapiens	77-82
25848797-7	2015	Interestingly, the affinity of these peptides is of the same order of magnitude of that reported for the interaction of full-length Cul3 with some BTB containing proteins.	btb	147-150	cullin 3	Homo sapiens	132-136
25538183-4	2014	Our genetic and biochemical experiments demonstrate that FRI directly interacts with the BTB (Bric-a-Brac/Tramtrack/Broad Complex) proteins LIGHT-RESPONSE BTB1 (LRB1) and LRB2 as well as the CULLIN3A (CUL3A) ubiquitin-E3 ligase in vitro and in vivo, leading to proteasomal degradation of FRI during vernalization.	btb	89-92	FRIGIDA-like protein	Arabidopsis thaliana	57-60
25538183-4	2014	Our genetic and biochemical experiments demonstrate that FRI directly interacts with the BTB (Bric-a-Brac/Tramtrack/Broad Complex) proteins LIGHT-RESPONSE BTB1 (LRB1) and LRB2 as well as the CULLIN3A (CUL3A) ubiquitin-E3 ligase in vitro and in vivo, leading to proteasomal degradation of FRI during vernalization.	btb	89-92	BTB/POZ/Kelch-associated protein	Arabidopsis thaliana	140-159
25538183-4	2014	Our genetic and biochemical experiments demonstrate that FRI directly interacts with the BTB (Bric-a-Brac/Tramtrack/Broad Complex) proteins LIGHT-RESPONSE BTB1 (LRB1) and LRB2 as well as the CULLIN3A (CUL3A) ubiquitin-E3 ligase in vitro and in vivo, leading to proteasomal degradation of FRI during vernalization.	btb	89-92	BTB/POZ/Kelch-associated protein	Arabidopsis thaliana	161-165
25538183-4	2014	Our genetic and biochemical experiments demonstrate that FRI directly interacts with the BTB (Bric-a-Brac/Tramtrack/Broad Complex) proteins LIGHT-RESPONSE BTB1 (LRB1) and LRB2 as well as the CULLIN3A (CUL3A) ubiquitin-E3 ligase in vitro and in vivo, leading to proteasomal degradation of FRI during vernalization.	btb	89-92	POZ/BTB containin G-protein 1	Arabidopsis thaliana	171-175
25538183-4	2014	Our genetic and biochemical experiments demonstrate that FRI directly interacts with the BTB (Bric-a-Brac/Tramtrack/Broad Complex) proteins LIGHT-RESPONSE BTB1 (LRB1) and LRB2 as well as the CULLIN3A (CUL3A) ubiquitin-E3 ligase in vitro and in vivo, leading to proteasomal degradation of FRI during vernalization.	btb	89-92	cullin 3	Arabidopsis thaliana	191-199
25538183-4	2014	Our genetic and biochemical experiments demonstrate that FRI directly interacts with the BTB (Bric-a-Brac/Tramtrack/Broad Complex) proteins LIGHT-RESPONSE BTB1 (LRB1) and LRB2 as well as the CULLIN3A (CUL3A) ubiquitin-E3 ligase in vitro and in vivo, leading to proteasomal degradation of FRI during vernalization.	btb	89-92	cullin 3	Arabidopsis thaliana	201-206
25538183-4	2014	Our genetic and biochemical experiments demonstrate that FRI directly interacts with the BTB (Bric-a-Brac/Tramtrack/Broad Complex) proteins LIGHT-RESPONSE BTB1 (LRB1) and LRB2 as well as the CULLIN3A (CUL3A) ubiquitin-E3 ligase in vitro and in vivo, leading to proteasomal degradation of FRI during vernalization.	btb	89-92	FRIGIDA-like protein	Arabidopsis thaliana	288-291
24578181-3	2014	Herein, we critically review the role of focal adhesion kinase (FAK) in coordinating the transport of spermatids and preleptotene spermatocytes across the epithelium and the BTB, respectively, along the apical ectoplasmic specialization (ES) - blood-testis barrier - basement membrane (BM) functional axis during spermatogenesis.	btb	174-177	protein tyrosine kinase 2	Homo sapiens	41-62
24578181-3	2014	Herein, we critically review the role of focal adhesion kinase (FAK) in coordinating the transport of spermatids and preleptotene spermatocytes across the epithelium and the BTB, respectively, along the apical ectoplasmic specialization (ES) - blood-testis barrier - basement membrane (BM) functional axis during spermatogenesis.	btb	174-177	protein tyrosine kinase 2	Homo sapiens	64-67
24578181-5	2014	Phosphorylated forms of FAK exert their effects by regulating the homeostasis of F-actin at the ES, mediated via their effects on actin polymerization so that microfilaments are efficiently re-organized, such as from their "bundled" to "de-bundled/branched" configuration and vice versa during the epithelial cycle to facilitate the transport of: (i) spermatids across the epithelium, and (ii) preleptotene spermatocytes across the BTB.	btb	432-435	protein tyrosine kinase 2	Homo sapiens	24-27
24743033-5	2014	Pep-1, one specific ligand of IL-13Ralpha2, was identified to exhibit excellent capacity of crossing the blood tumor barrier (BTB) and homing to giloma.	btb	126-129	interleukin 13 receptor subunit alpha 2	Rattus norvegicus	30-42
24318462-3	2014	However, our knowledge about the expression and function of KLF4 in the endothelial cells of BTB still remains unclear.	btb	93-96	Kruppel like factor 4	Homo sapiens	60-64
24318462-4	2014	In this study, we sought to investigate the role of KLF4 in regulation of BTB function as well as the potential molecular mechanisms.	btb	74-77	Kruppel like factor 4	Homo sapiens	52-56
24318462-6	2014	Short hairpin RNA targeting KLF4 impaired the integrity of BTB detected by trans-endothelial electric resistance assay, and meanwhile reduced the expression of ZO-1, occludin and claudin-5, demonstrated by quantitative RT-PCR, Western blot, and immunofluorescence assays.	btb	59-62	Kruppel like factor 4	Homo sapiens	28-32
24318462-7	2014	Depletion of KLF4 increased BTB permeability to small molecules detected by permeability assays.	btb	28-31	Kruppel like factor 4	Homo sapiens	13-17
24526454-13	2014	We suggest that low-dose EMAP-II can induce BTB hyperpermeability via the transcellular pathway, which is associated with phosphorylation and upregulation of caveolin-1 and caveolin-2 and involves the tyrosine kinase/RhoA/Rho kinase signaling pathway.	btb	44-47	caveolin 1	Rattus norvegicus	158-168
24896564-4	2014	We report here the first structure of the BTB domain of Keap1, which is thought to contain the key cysteine residue responsible for interaction with electrophiles, as well as structures of the covalent complex with the antagonist CDDO/bardoxolone, and of the constitutively inactive C151W BTB mutant.	btb	42-45	kelch like ECH associated protein 1	Homo sapiens	56-61
24896564-4	2014	We report here the first structure of the BTB domain of Keap1, which is thought to contain the key cysteine residue responsible for interaction with electrophiles, as well as structures of the covalent complex with the antagonist CDDO/bardoxolone, and of the constitutively inactive C151W BTB mutant.	btb	289-292	kelch like ECH associated protein 1	Homo sapiens	56-61
24896564-5	2014	In addition to providing the first structural confirmation of antagonist binding to Keap1 BTB, we also present biochemical evidence that adduction of Cys 151 by CDDO is capable of inhibiting the binding of Cul3 to Keap1, and discuss how this class of compound might exert Nrf2 activation through disruption of the BTB-Cul3 interface.	btb	90-93	kelch like ECH associated protein 1	Homo sapiens	84-89
24896564-5	2014	In addition to providing the first structural confirmation of antagonist binding to Keap1 BTB, we also present biochemical evidence that adduction of Cys 151 by CDDO is capable of inhibiting the binding of Cul3 to Keap1, and discuss how this class of compound might exert Nrf2 activation through disruption of the BTB-Cul3 interface.	btb	314-317	cullin 3	Homo sapiens	206-210
24523141-2	2014	In the rat C6 glioma model, the extravasation of Evans blue (EB) through the BTB was increased significantly by VEGF and PA.	btb	77-80	vascular endothelial growth factor A	Rattus norvegicus	112-116
24523141-7	2014	This study demonstrates that combination of VEGF and PA can increase the permeability of the BTB by a paracellular pathway (downregulation of occludin and claudin-5) and a transcellular pathway (upregulation of caveolin-1 and caveolin-2) and that the cGMP/PKG/NF-kappaB signal pathway might be involved in the modulation process.	btb	93-96	vascular endothelial growth factor A	Rattus norvegicus	44-48
24523141-7	2014	This study demonstrates that combination of VEGF and PA can increase the permeability of the BTB by a paracellular pathway (downregulation of occludin and claudin-5) and a transcellular pathway (upregulation of caveolin-1 and caveolin-2) and that the cGMP/PKG/NF-kappaB signal pathway might be involved in the modulation process.	btb	93-96	occludin	Rattus norvegicus	142-150
24523141-7	2014	This study demonstrates that combination of VEGF and PA can increase the permeability of the BTB by a paracellular pathway (downregulation of occludin and claudin-5) and a transcellular pathway (upregulation of caveolin-1 and caveolin-2) and that the cGMP/PKG/NF-kappaB signal pathway might be involved in the modulation process.	btb	93-96	claudin 5	Rattus norvegicus	155-164
24523141-7	2014	This study demonstrates that combination of VEGF and PA can increase the permeability of the BTB by a paracellular pathway (downregulation of occludin and claudin-5) and a transcellular pathway (upregulation of caveolin-1 and caveolin-2) and that the cGMP/PKG/NF-kappaB signal pathway might be involved in the modulation process.	btb	93-96	caveolin 1	Rattus norvegicus	211-221
24523141-7	2014	This study demonstrates that combination of VEGF and PA can increase the permeability of the BTB by a paracellular pathway (downregulation of occludin and claudin-5) and a transcellular pathway (upregulation of caveolin-1 and caveolin-2) and that the cGMP/PKG/NF-kappaB signal pathway might be involved in the modulation process.	btb	93-96	caveolin 2	Rattus norvegicus	226-236
24522926-6	2014	Significantly, expression of the BTB-only domain of EVM150 blocked NF-kappaB activation, demonstrating that EVM150 functioned independently of the kelch domain and its role as an adapter for cullin-3-based ubiquitin ligases.	btb	33-36	cullin 3	Homo sapiens	191-199
24736394-5	2014	We further mapped the interaction regions to the 1-9 armadillo repeats of beta-catenin and the BTB domain of KCTD1, especially Position Ala-30 and His-33.	btb	95-98	potassium channel tetramerization domain containing 1	Homo sapiens	109-114
24705869-2	2014	In this study, we found a significant increase in the permeability of BTB by mediating the association of the C-terminus of alpha subunit of human large-conductance calcium-activated potassium channels (hSlo1c) with caveolin-1 (Cav-1).	btb	70-73	caveolin 1	Homo sapiens	216-226
24705869-2	2014	In this study, we found a significant increase in the permeability of BTB by mediating the association of the C-terminus of alpha subunit of human large-conductance calcium-activated potassium channels (hSlo1c) with caveolin-1 (Cav-1).	btb	70-73	caveolin 1	Homo sapiens	228-233
24705869-6	2014	This effect was attenuated by filipin, an agent disrupting caveolae or deletion of the potential interaction fragment, suggesting hSlo1c/Cav-1 association is crucial for regulating the permeability of BTB.	btb	201-204	caveolin 1	Homo sapiens	137-142
24705869-8	2014	Our study indicates that cytoplasmic hSlo1c not only associates with Cav-1 but also has functional consequences on the permeability of BTB by triggering the intracellular trafficking of its interacting protein partner, Cav-1.	btb	135-138	caveolin 1	Homo sapiens	219-224
24412753-3	2014	BTB, as a negative regulator of cell cycle progression, was identified as a HMGB1 interacting partner.	btb	0-3	high mobility group box 1	Homo sapiens	76-81
24412753-4	2014	The ectopic expression of HMGB1 activates cell growth by suppressing BTB-induced cell death, decreasing Bax and p53 expression, while enhancing Bcl-xL, Bcl-2, cyclin D1, and NF-kappaB expression.	btb	69-72	high mobility group box 1	Homo sapiens	26-31
24412753-5	2014	HMGB1 activates the FAK/PI3K/mTOR signaling cascade, and BTB prominently inhibits HMGB1-induced oncogenesis.	btb	57-60	high mobility group box 1	Homo sapiens	82-87
24526454-13	2014	We suggest that low-dose EMAP-II can induce BTB hyperpermeability via the transcellular pathway, which is associated with phosphorylation and upregulation of caveolin-1 and caveolin-2 and involves the tyrosine kinase/RhoA/Rho kinase signaling pathway.	btb	44-47	caveolin 2	Rattus norvegicus	173-183
24526454-13	2014	We suggest that low-dose EMAP-II can induce BTB hyperpermeability via the transcellular pathway, which is associated with phosphorylation and upregulation of caveolin-1 and caveolin-2 and involves the tyrosine kinase/RhoA/Rho kinase signaling pathway.	btb	44-47	ras homolog family member A	Rattus norvegicus	217-221
25221777-3	2014	Here, we found 3-butoxy-1,8,9-trihydroxy-6H-benzofuro[3,2-c]benzopyran-6-one (BTB), a new derivative of wedelolactone, could effectively inhibit the 17-estradiol (E2)-induced ER transactivation and suppress the growth of breast cancer as well as endometrial and ovarian cancer cells.	btb	78-81	estrogen receptor 1	Homo sapiens	175-177
24450635-3	2014	The Cul3-based CRLs uniquely assemble with BTB (broad complex/tramtrack/bric-a-brac) proteins that also homodimerize and perform the role of both the Cullin adapter and the substrate-recognition component of the E3.	btb	43-46	cullin 3	Homo sapiens	4-8
24450635-3	2014	The Cul3-based CRLs uniquely assemble with BTB (broad complex/tramtrack/bric-a-brac) proteins that also homodimerize and perform the role of both the Cullin adapter and the substrate-recognition component of the E3.	btb	43-46	CDK2 associated cullin domain 1	Homo sapiens	150-156
25221777-4	2014	Our results indicate that 2.5 muM BTB effectively suppresses ER-positive, but not ER-negative, breast, endometrial, and ovarian cancer cells.	btb	34-37	estrogen receptor 1	Homo sapiens	61-63
25221777-5	2014	Furthermore, our data indicate that BTB can modulate ER transactivation and suppress the expression of E2-mediated ER target genes (Cyclin D1, E2F1, and TERT) in the ER-positive MCF-7, Ishikawa, and SKOV-3 cells.	btb	36-39	estrogen receptor 1	Homo sapiens	53-55
25221777-5	2014	Furthermore, our data indicate that BTB can modulate ER transactivation and suppress the expression of E2-mediated ER target genes (Cyclin D1, E2F1, and TERT) in the ER-positive MCF-7, Ishikawa, and SKOV-3 cells.	btb	36-39	cyclin D1	Homo sapiens	132-141
25221777-5	2014	Furthermore, our data indicate that BTB can modulate ER transactivation and suppress the expression of E2-mediated ER target genes (Cyclin D1, E2F1, and TERT) in the ER-positive MCF-7, Ishikawa, and SKOV-3 cells.	btb	36-39	E2F transcription factor 1	Homo sapiens	143-147
25221777-5	2014	Furthermore, our data indicate that BTB can modulate ER transactivation and suppress the expression of E2-mediated ER target genes (Cyclin D1, E2F1, and TERT) in the ER-positive MCF-7, Ishikawa, and SKOV-3 cells.	btb	36-39	telomerase reverse transcriptase	Homo sapiens	153-157
25221777-5	2014	Furthermore, our data indicate that BTB can modulate ER transactivation and suppress the expression of E2-mediated ER target genes (Cyclin D1, E2F1, and TERT) in the ER-positive MCF-7, Ishikawa, and SKOV-3 cells.	btb	36-39	estrogen receptor 1	Homo sapiens	115-117
25221777-6	2014	Importantly, this BTB mediated inhibition of ER activity is selective since BTB does not suppress the activities of other nuclear receptors, including glucocorticoid receptor and progesterone receptor, suggesting that BTB functions as a selective ER signaling inhibitor with the potential to treat breast, endometrial, and ovarian cancers.	btb	18-21	estrogen receptor 1	Homo sapiens	45-47
25221777-6	2014	Importantly, this BTB mediated inhibition of ER activity is selective since BTB does not suppress the activities of other nuclear receptors, including glucocorticoid receptor and progesterone receptor, suggesting that BTB functions as a selective ER signaling inhibitor with the potential to treat breast, endometrial, and ovarian cancers.	btb	18-21	estrogen receptor 1	Homo sapiens	247-249
25221777-6	2014	Importantly, this BTB mediated inhibition of ER activity is selective since BTB does not suppress the activities of other nuclear receptors, including glucocorticoid receptor and progesterone receptor, suggesting that BTB functions as a selective ER signaling inhibitor with the potential to treat breast, endometrial, and ovarian cancers.	btb	76-79	estrogen receptor 1	Homo sapiens	45-47
25221777-6	2014	Importantly, this BTB mediated inhibition of ER activity is selective since BTB does not suppress the activities of other nuclear receptors, including glucocorticoid receptor and progesterone receptor, suggesting that BTB functions as a selective ER signaling inhibitor with the potential to treat breast, endometrial, and ovarian cancers.	btb	76-79	estrogen receptor 1	Homo sapiens	247-249
25221777-6	2014	Importantly, this BTB mediated inhibition of ER activity is selective since BTB does not suppress the activities of other nuclear receptors, including glucocorticoid receptor and progesterone receptor, suggesting that BTB functions as a selective ER signaling inhibitor with the potential to treat breast, endometrial, and ovarian cancers.	btb	76-79	estrogen receptor 1	Homo sapiens	45-47
25221777-6	2014	Importantly, this BTB mediated inhibition of ER activity is selective since BTB does not suppress the activities of other nuclear receptors, including glucocorticoid receptor and progesterone receptor, suggesting that BTB functions as a selective ER signaling inhibitor with the potential to treat breast, endometrial, and ovarian cancers.	btb	76-79	estrogen receptor 1	Homo sapiens	247-249
24351049-9	2014	Dogs with BTB had significantly higher CRP concentrations than dogs with CB (P = .001) or EBP (P &lt; .0001) and healthy controls (P = .029).	btb	10-13	C-reactive protein	Canis lupus familiaris	39-42
24086424-0	2013	The BTB-containing protein Kctd15 is SUMOylated in vivo.	btb	4-7	potassium channel tetramerization domain containing 15b	Danio rerio	27-33
24268103-4	2013	In this review, we summarize the character of Bric-a-brack,Tram-track, Broad complex(BTB) of KCTD proteins, their roles in the ubiquitination pathway, and the roles of KCTD mutants in diseases.	btb	85-88	ATPase phospholipid transporting 8B1	Homo sapiens	46-50
23973310-5	2013	The inhibitor of ROS or RhoA or PI3K or PKB significantly attenuated the expression of tight junction (TJ) protein and the increase of the BTB permeability after 2 h of MS treatment.	btb	139-142	ras homolog family member A	Rattus norvegicus	24-28
23973310-7	2013	The present study indicates that the activation of signaling cascades involving ROS/RhoA/PI3K/PKB in BTB was required for the increase of BTB permeability induced by MS. Taken together, all of these results suggested that MS might increase BTB permeability in a time-dependent manner by down-regulating TJ protein expression and this effect could be related to ROS/RhoA/PI3K/PKB signal pathway.	btb	101-104	ras homolog family member A	Rattus norvegicus	84-88
23973310-7	2013	The present study indicates that the activation of signaling cascades involving ROS/RhoA/PI3K/PKB in BTB was required for the increase of BTB permeability induced by MS. Taken together, all of these results suggested that MS might increase BTB permeability in a time-dependent manner by down-regulating TJ protein expression and this effect could be related to ROS/RhoA/PI3K/PKB signal pathway.	btb	101-104	ras homolog family member A	Rattus norvegicus	365-369
23973310-7	2013	The present study indicates that the activation of signaling cascades involving ROS/RhoA/PI3K/PKB in BTB was required for the increase of BTB permeability induced by MS. Taken together, all of these results suggested that MS might increase BTB permeability in a time-dependent manner by down-regulating TJ protein expression and this effect could be related to ROS/RhoA/PI3K/PKB signal pathway.	btb	138-141	ras homolog family member A	Rattus norvegicus	84-88
23973310-7	2013	The present study indicates that the activation of signaling cascades involving ROS/RhoA/PI3K/PKB in BTB was required for the increase of BTB permeability induced by MS. Taken together, all of these results suggested that MS might increase BTB permeability in a time-dependent manner by down-regulating TJ protein expression and this effect could be related to ROS/RhoA/PI3K/PKB signal pathway.	btb	138-141	ras homolog family member A	Rattus norvegicus	365-369
23973310-7	2013	The present study indicates that the activation of signaling cascades involving ROS/RhoA/PI3K/PKB in BTB was required for the increase of BTB permeability induced by MS. Taken together, all of these results suggested that MS might increase BTB permeability in a time-dependent manner by down-regulating TJ protein expression and this effect could be related to ROS/RhoA/PI3K/PKB signal pathway.	btb	138-141	ras homolog family member A	Rattus norvegicus	84-88
23973310-7	2013	The present study indicates that the activation of signaling cascades involving ROS/RhoA/PI3K/PKB in BTB was required for the increase of BTB permeability induced by MS. Taken together, all of these results suggested that MS might increase BTB permeability in a time-dependent manner by down-regulating TJ protein expression and this effect could be related to ROS/RhoA/PI3K/PKB signal pathway.	btb	138-141	ras homolog family member A	Rattus norvegicus	365-369
23932144-11	2013	In the light of the logistical hassle around the implantation, the need of dexterity, and the risk of anaesthesia and peri-operative complications associated with BTB, CKB might be regarded as the optimal option to boost early-stage OPC.	btb	163-166	creatine kinase B	Homo sapiens	168-171
23707491-2	2013	TGF-beta3 is a key molecule involved in BTB permeability via regulation of tight junction proteins, and it participates in regulating spermatogenesis, synthesis of steroids and production of the extracellular matrix in testicular tissue.	btb	40-43	transforming growth factor, beta 3	Mus musculus	0-9
23707491-3	2013	Therefore, it is hypothesized that TGF-beta3 plays important roles in electromagnetic pulse (EMP)-induced changes in BTB permeability.	btb	117-120	transforming growth factor, beta 3	Mus musculus	35-44
23707491-7	2013	These results indicate that increase in the apoptotic rate of testicular tissues and increase in TGF-beta3 expression may be one of the mechanisms for EMP-induced increase in BTB permeability in mice.	btb	175-178	transforming growth factor, beta 3	Mus musculus	97-106
24067371-6	2013	Our own recent study identified the mitotic kinase PLK1 as a direct target of the CUL3 E3-ligase complex containing BTB-KELCH adaptor protein KLHL22.	btb	116-119	polo like kinase 1	Homo sapiens	51-55
24067371-6	2013	Our own recent study identified the mitotic kinase PLK1 as a direct target of the CUL3 E3-ligase complex containing BTB-KELCH adaptor protein KLHL22.	btb	116-119	cullin 3	Homo sapiens	82-86
24067371-6	2013	Our own recent study identified the mitotic kinase PLK1 as a direct target of the CUL3 E3-ligase complex containing BTB-KELCH adaptor protein KLHL22.	btb	116-119	kelch like family member 22	Homo sapiens	142-148
23582684-7	2013	In vivo imaging and glioma distribution together confirmed that MT1-AF7p functionalization and iRGD co-administration significantly improved the nanoparticles extravasation across BTB and accumulation in glioma parenchyma.	btb	180-183	metallothionein 1	Mus musculus	64-67
23582684-7	2013	In vivo imaging and glioma distribution together confirmed that MT1-AF7p functionalization and iRGD co-administration significantly improved the nanoparticles extravasation across BTB and accumulation in glioma parenchyma.	btb	180-183	interferon gamma inducible protein 47	Mus musculus	95-99
23595903-10	2013	The use of biotin tracers showed increased BTB permeability in the Sox8(-/-) adult testes.	btb	43-46	SRY (sex determining region Y)-box 8	Mus musculus	67-71
23847398-3	2013	The Nrf2 transcription function and its degradation by the proteasomal pathway (Keap1-Nrf2-Cul3-Roc1 complex) are regulated by the cytoplasmic repressor protein, Keap1 which possesses BTB, BACK (IVR region) and Kelch domains.	btb	184-187	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
23847398-3	2013	The Nrf2 transcription function and its degradation by the proteasomal pathway (Keap1-Nrf2-Cul3-Roc1 complex) are regulated by the cytoplasmic repressor protein, Keap1 which possesses BTB, BACK (IVR region) and Kelch domains.	btb	184-187	kelch like ECH associated protein 1	Homo sapiens	80-85
23847398-3	2013	The Nrf2 transcription function and its degradation by the proteasomal pathway (Keap1-Nrf2-Cul3-Roc1 complex) are regulated by the cytoplasmic repressor protein, Keap1 which possesses BTB, BACK (IVR region) and Kelch domains.	btb	184-187	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
23847398-3	2013	The Nrf2 transcription function and its degradation by the proteasomal pathway (Keap1-Nrf2-Cul3-Roc1 complex) are regulated by the cytoplasmic repressor protein, Keap1 which possesses BTB, BACK (IVR region) and Kelch domains.	btb	184-187	cullin 3	Homo sapiens	91-95
23847398-3	2013	The Nrf2 transcription function and its degradation by the proteasomal pathway (Keap1-Nrf2-Cul3-Roc1 complex) are regulated by the cytoplasmic repressor protein, Keap1 which possesses BTB, BACK (IVR region) and Kelch domains.	btb	184-187	ring-box 1	Homo sapiens	96-100
23847398-3	2013	The Nrf2 transcription function and its degradation by the proteasomal pathway (Keap1-Nrf2-Cul3-Roc1 complex) are regulated by the cytoplasmic repressor protein, Keap1 which possesses BTB, BACK (IVR region) and Kelch domains.	btb	184-187	kelch like ECH associated protein 1	Homo sapiens	162-167
23847398-7	2013	The electrostatic charge distribution at the BTB dimer interface of Keap1 is significantly different from other known BTB containing protein structures.	btb	45-48	kelch like ECH associated protein 1	Homo sapiens	68-73
23847398-7	2013	The electrostatic charge distribution at the BTB dimer interface of Keap1 is significantly different from other known BTB containing protein structures.	btb	118-121	kelch like ECH associated protein 1	Homo sapiens	68-73
23262290-4	2013	Previous studies have shown an array of cellular events, including protein internalization and cytoskeletal remodeling, to underline blood-testis barrier restructuring, whereas other studies have reported BTB dysfunction to associate with activation of the p38 mitogen-activated protein kinase pathway.	btb	205-208	mitogen-activated protein kinase 14	Homo sapiens	257-260
23349464-2	2013	Cul3-based Cullin-RING ligases are uniquely associated with BTB adaptors that incorporate homodimerization, Cul3 assembly, and substrate recognition into a single multidomain protein, of which the best known are BTB-BACK-Kelch domain proteins, including KEAP1.	btb	60-63	cullin 3	Homo sapiens	0-4
23349464-2	2013	Cul3-based Cullin-RING ligases are uniquely associated with BTB adaptors that incorporate homodimerization, Cul3 assembly, and substrate recognition into a single multidomain protein, of which the best known are BTB-BACK-Kelch domain proteins, including KEAP1.	btb	60-63	cullin 3	Homo sapiens	108-112
23349464-2	2013	Cul3-based Cullin-RING ligases are uniquely associated with BTB adaptors that incorporate homodimerization, Cul3 assembly, and substrate recognition into a single multidomain protein, of which the best known are BTB-BACK-Kelch domain proteins, including KEAP1.	btb	60-63	kelch like ECH associated protein 1	Homo sapiens	254-259
23349464-4	2013	To define the molecular basis for this assembly and the overall architecture of the E3, we determined the crystal structures of the BTB-BACK domains of KLHL11 both alone and in complex with Cul3, along with the Kelch domain structures of KLHL2 (Mayven), KLHL7, KLHL12, and KBTBD5.	btb	132-135	kelch like family member 11	Homo sapiens	152-158
23349464-5	2013	We show that Cul3 interaction is dependent on a unique N-terminal extension sequence that packs against the 3-box in a hydrophobic groove centrally located between the BTB and BACK domains.	btb	168-171	cullin 3	Homo sapiens	13-17