PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6161675-3 1981 Analysis of the purified myelin by SDS-polyacrylamide gel electrophoresis revealed that P1 and Pr, which are common to BP in CNS, and PM protein were missing, while P0 and P2 proteins were of the same level as the control. Benzo(a)pyrene 119-121 zinc finger protein 185 Mus musculus 88-97 30210697-0 2018 Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt/beta-catenin pathway. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 137-149 30210697-5 2018 Our data preliminarily indicate that LiCl induces MM cell apoptosis via activating the Wnt/beta-catenin signaling pathway. Lithium Chloride 37-41 catenin beta 1 Homo sapiens 91-103 28871429-6 2018 Interestingly, treatment with lithium chloride, which is a well-known inhibitor of GSK3beta, partially recovered the expression of ATF4 protein, but its effect on the level of total c-Myc protein was negligible. Lithium Chloride 30-46 glycogen synthase kinase 3 beta Homo sapiens 83-91 28871429-6 2018 Interestingly, treatment with lithium chloride, which is a well-known inhibitor of GSK3beta, partially recovered the expression of ATF4 protein, but its effect on the level of total c-Myc protein was negligible. Lithium Chloride 30-46 activating transcription factor 4 Homo sapiens 131-135 28871429-6 2018 Interestingly, treatment with lithium chloride, which is a well-known inhibitor of GSK3beta, partially recovered the expression of ATF4 protein, but its effect on the level of total c-Myc protein was negligible. Lithium Chloride 30-46 MYC proto-oncogene, bHLH transcription factor Homo sapiens 182-187 29968965-6 2018 Furthermore, IQUB overexpression or knockdown combined with treatment of Licl or MG-132 showed that IQUB activated Akt to promote GSK3beta phosphorylation, which in turn activated Wnt/beta-catenin signaling pathway in breast cancer cells. Lithium Chloride 73-77 AKT serine/threonine kinase 1 Homo sapiens 115-118 29968965-6 2018 Furthermore, IQUB overexpression or knockdown combined with treatment of Licl or MG-132 showed that IQUB activated Akt to promote GSK3beta phosphorylation, which in turn activated Wnt/beta-catenin signaling pathway in breast cancer cells. Lithium Chloride 73-77 glycogen synthase kinase 3 beta Homo sapiens 130-138 29968965-6 2018 Furthermore, IQUB overexpression or knockdown combined with treatment of Licl or MG-132 showed that IQUB activated Akt to promote GSK3beta phosphorylation, which in turn activated Wnt/beta-catenin signaling pathway in breast cancer cells. Lithium Chloride 73-77 catenin beta 1 Homo sapiens 184-196 29679546-0 2018 Lithium chloride (LiCl) induced autophagy and downregulated expression of transforming growth factor beta-induced protein (TGFBI) in granular corneal dystrophy. Lithium Chloride 0-16 transforming growth factor beta induced Homo sapiens 74-121 29679546-0 2018 Lithium chloride (LiCl) induced autophagy and downregulated expression of transforming growth factor beta-induced protein (TGFBI) in granular corneal dystrophy. Lithium Chloride 0-16 transforming growth factor beta induced Homo sapiens 123-128 29679546-0 2018 Lithium chloride (LiCl) induced autophagy and downregulated expression of transforming growth factor beta-induced protein (TGFBI) in granular corneal dystrophy. Lithium Chloride 18-22 transforming growth factor beta induced Homo sapiens 74-121 29679546-0 2018 Lithium chloride (LiCl) induced autophagy and downregulated expression of transforming growth factor beta-induced protein (TGFBI) in granular corneal dystrophy. Lithium Chloride 18-22 transforming growth factor beta induced Homo sapiens 123-128 29679546-1 2018 This study evaluated whether lithium chloride (LiCl) prevents cytoplasmic accumulation of mutant-transforming growth factor beta-induced protein (Mut-TGFBI) in granular corneal dystrophy (GCD) via activation of the autophagy pathway. Lithium Chloride 29-45 transforming growth factor beta induced Homo sapiens 97-144 29679546-1 2018 This study evaluated whether lithium chloride (LiCl) prevents cytoplasmic accumulation of mutant-transforming growth factor beta-induced protein (Mut-TGFBI) in granular corneal dystrophy (GCD) via activation of the autophagy pathway. Lithium Chloride 29-45 transforming growth factor beta induced Homo sapiens 150-155 29679546-1 2018 This study evaluated whether lithium chloride (LiCl) prevents cytoplasmic accumulation of mutant-transforming growth factor beta-induced protein (Mut-TGFBI) in granular corneal dystrophy (GCD) via activation of the autophagy pathway. Lithium Chloride 47-51 transforming growth factor beta induced Homo sapiens 97-144 29679546-1 2018 This study evaluated whether lithium chloride (LiCl) prevents cytoplasmic accumulation of mutant-transforming growth factor beta-induced protein (Mut-TGFBI) in granular corneal dystrophy (GCD) via activation of the autophagy pathway. Lithium Chloride 47-51 transforming growth factor beta induced Homo sapiens 150-155 29679546-9 2018 LiCl enhanced autophagy in mutant type TGFBI over-expressed cells and recovered cell viability in those cells. Lithium Chloride 0-4 transforming growth factor beta induced Homo sapiens 39-44 29679546-11 2018 To summarize, treatment with LiCl inhibited the expression of TGFBI and recovery the inhibitory of mutant type TGFBI in cell viability, at least part through enhancing of autophagy. Lithium Chloride 29-33 transforming growth factor beta induced Homo sapiens 62-67 29679546-11 2018 To summarize, treatment with LiCl inhibited the expression of TGFBI and recovery the inhibitory of mutant type TGFBI in cell viability, at least part through enhancing of autophagy. Lithium Chloride 29-33 transforming growth factor beta induced Homo sapiens 111-116 30073198-5 2018 Systemic pretreatment with the MAGL inhibitor, MJN110, prevented the LiCl-induced elevation of 5-HT in the IIC. Lithium Chloride 69-73 monoglyceride lipase Rattus norvegicus 31-35 30013652-9 2018 Lithium chloride (LiCl), a GSK-3beta inhibitor, prevented juglone-mediated downregulation of Snail expression and upregulation of E-cadherin. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Homo sapiens 27-36 30013652-9 2018 Lithium chloride (LiCl), a GSK-3beta inhibitor, prevented juglone-mediated downregulation of Snail expression and upregulation of E-cadherin. Lithium Chloride 0-16 snail family transcriptional repressor 1 Homo sapiens 93-98 30013652-9 2018 Lithium chloride (LiCl), a GSK-3beta inhibitor, prevented juglone-mediated downregulation of Snail expression and upregulation of E-cadherin. Lithium Chloride 0-16 cadherin 1 Homo sapiens 130-140 30013652-9 2018 Lithium chloride (LiCl), a GSK-3beta inhibitor, prevented juglone-mediated downregulation of Snail expression and upregulation of E-cadherin. Lithium Chloride 18-22 glycogen synthase kinase 3 beta Homo sapiens 27-36 30013652-9 2018 Lithium chloride (LiCl), a GSK-3beta inhibitor, prevented juglone-mediated downregulation of Snail expression and upregulation of E-cadherin. Lithium Chloride 18-22 snail family transcriptional repressor 1 Homo sapiens 93-98 30013652-9 2018 Lithium chloride (LiCl), a GSK-3beta inhibitor, prevented juglone-mediated downregulation of Snail expression and upregulation of E-cadherin. Lithium Chloride 18-22 cadherin 1 Homo sapiens 130-140 30073198-7 2018 Since 5-HT3 receptor agonists delivered to the IIC produce nausea, we tested and confirmed the hypothesis that the intra-IIC administration of 5-HT3 receptor antagonist, ondansetron, but not MJN110, would prevent LiCl-induced conditioned gaping reactions produced by intra-IIC administration of the 5-HT3 receptor agonist, m-chlorophenylbiguanide (mCPBG). Lithium Chloride 213-217 5-hydroxytryptamine receptor 3A Rattus norvegicus 143-157 30073198-7 2018 Since 5-HT3 receptor agonists delivered to the IIC produce nausea, we tested and confirmed the hypothesis that the intra-IIC administration of 5-HT3 receptor antagonist, ondansetron, but not MJN110, would prevent LiCl-induced conditioned gaping reactions produced by intra-IIC administration of the 5-HT3 receptor agonist, m-chlorophenylbiguanide (mCPBG). Lithium Chloride 213-217 5-hydroxytryptamine receptor 3A Rattus norvegicus 143-157 29773200-0 2018 Lithium chloride attenuates mitomycin C induced necrotic cell death in MDA-MB-231 breast cancer cells via HMGB1 and Bax signaling. Lithium Chloride 0-16 high mobility group box 1 Homo sapiens 106-111 30123351-5 2018 Moreover, phosphor mutants of CAP1 at the S307/S309 regulatory site had compromised rescue effects for both the invasiveness and the proliferation in CAP1-knockdown cells and GSK3beta kinase inhibitor LiCl inhibited cell phosphorylation site S307/S309 by up-regulating the expression of p53, BAK, BAD and cleaved PARP induced ROS production, decreased lung cancer cell viability, adhesion, proliferation, migration and invasion, and induction of apoptosis. Lithium Chloride 201-205 cyclase associated actin cytoskeleton regulatory protein 1 Homo sapiens 30-34 30123351-5 2018 Moreover, phosphor mutants of CAP1 at the S307/S309 regulatory site had compromised rescue effects for both the invasiveness and the proliferation in CAP1-knockdown cells and GSK3beta kinase inhibitor LiCl inhibited cell phosphorylation site S307/S309 by up-regulating the expression of p53, BAK, BAD and cleaved PARP induced ROS production, decreased lung cancer cell viability, adhesion, proliferation, migration and invasion, and induction of apoptosis. Lithium Chloride 201-205 glycogen synthase kinase 3 beta Homo sapiens 175-183 30123351-5 2018 Moreover, phosphor mutants of CAP1 at the S307/S309 regulatory site had compromised rescue effects for both the invasiveness and the proliferation in CAP1-knockdown cells and GSK3beta kinase inhibitor LiCl inhibited cell phosphorylation site S307/S309 by up-regulating the expression of p53, BAK, BAD and cleaved PARP induced ROS production, decreased lung cancer cell viability, adhesion, proliferation, migration and invasion, and induction of apoptosis. Lithium Chloride 201-205 tumor protein p53 Homo sapiens 287-290 30123351-5 2018 Moreover, phosphor mutants of CAP1 at the S307/S309 regulatory site had compromised rescue effects for both the invasiveness and the proliferation in CAP1-knockdown cells and GSK3beta kinase inhibitor LiCl inhibited cell phosphorylation site S307/S309 by up-regulating the expression of p53, BAK, BAD and cleaved PARP induced ROS production, decreased lung cancer cell viability, adhesion, proliferation, migration and invasion, and induction of apoptosis. Lithium Chloride 201-205 BCL2 antagonist/killer 1 Homo sapiens 292-295 30123351-5 2018 Moreover, phosphor mutants of CAP1 at the S307/S309 regulatory site had compromised rescue effects for both the invasiveness and the proliferation in CAP1-knockdown cells and GSK3beta kinase inhibitor LiCl inhibited cell phosphorylation site S307/S309 by up-regulating the expression of p53, BAK, BAD and cleaved PARP induced ROS production, decreased lung cancer cell viability, adhesion, proliferation, migration and invasion, and induction of apoptosis. Lithium Chloride 201-205 poly(ADP-ribose) polymerase 1 Homo sapiens 313-317 29709598-2 2018 Ultraviolet (UV) or lithium chloride (LiCl) treatment are classic embryonic manipulations frequently used to perturb specification of the dorso-ventral (DV) axis by affecting the stability of the maternal Wnt mediator beta-catenin. Lithium Chloride 20-36 catenin beta 1 Xenopus tropicalis 218-230 29709598-2 2018 Ultraviolet (UV) or lithium chloride (LiCl) treatment are classic embryonic manipulations frequently used to perturb specification of the dorso-ventral (DV) axis by affecting the stability of the maternal Wnt mediator beta-catenin. Lithium Chloride 38-42 catenin beta 1 Xenopus tropicalis 218-230 29436118-9 2018 The inhibitory effects of CST on ALP activity, calcium deposition and beta-catenin protein were abolished by pretreatment with lithium chloride, a GSK3beta inhibitor. Lithium Chloride 127-143 cortistatin Rattus norvegicus 26-29 29436118-9 2018 The inhibitory effects of CST on ALP activity, calcium deposition and beta-catenin protein were abolished by pretreatment with lithium chloride, a GSK3beta inhibitor. Lithium Chloride 127-143 catenin beta 1 Rattus norvegicus 70-82 29436118-9 2018 The inhibitory effects of CST on ALP activity, calcium deposition and beta-catenin protein were abolished by pretreatment with lithium chloride, a GSK3beta inhibitor. Lithium Chloride 127-143 glycogen synthase kinase 3 beta Rattus norvegicus 147-155 29659176-4 2018 Here we showed that treatment with a Wnt pathway activator (LiCl) reduced elastase-induced airspace enlargement and cigarette smoke extract (CSE)-induced lung inflammatory responses in WT mice, which was associated with increased activation of Nrf2 pathway. Lithium Chloride 60-64 Wnt family member 3A Homo sapiens 37-40 29659176-4 2018 Here we showed that treatment with a Wnt pathway activator (LiCl) reduced elastase-induced airspace enlargement and cigarette smoke extract (CSE)-induced lung inflammatory responses in WT mice, which was associated with increased activation of Nrf2 pathway. Lithium Chloride 60-64 nuclear factor, erythroid derived 2, like 2 Mus musculus 244-248 29773200-0 2018 Lithium chloride attenuates mitomycin C induced necrotic cell death in MDA-MB-231 breast cancer cells via HMGB1 and Bax signaling. Lithium Chloride 0-16 BCL2 associated X, apoptosis regulator Homo sapiens 116-119 29773200-8 2018 LiCl combined with mitomycin C significantly down-regulated HMGB1, MMP9 and Bcl-2 gene expression but significantly increased the level of Bax protein. Lithium Chloride 0-4 high mobility group box 1 Homo sapiens 60-65 29773200-8 2018 LiCl combined with mitomycin C significantly down-regulated HMGB1, MMP9 and Bcl-2 gene expression but significantly increased the level of Bax protein. Lithium Chloride 0-4 matrix metallopeptidase 9 Homo sapiens 67-71 29773200-8 2018 LiCl combined with mitomycin C significantly down-regulated HMGB1, MMP9 and Bcl-2 gene expression but significantly increased the level of Bax protein. Lithium Chloride 0-4 BCL2 apoptosis regulator Homo sapiens 76-81 29773200-8 2018 LiCl combined with mitomycin C significantly down-regulated HMGB1, MMP9 and Bcl-2 gene expression but significantly increased the level of Bax protein. Lithium Chloride 0-4 BCL2 associated X, apoptosis regulator Homo sapiens 139-142 29773200-9 2018 In addition, the content of HMGB1 in the nuclei decreased and pretreatment with LiCl reduced the content of HMGB1 release induced by MMC. Lithium Chloride 80-84 high mobility group box 1 Homo sapiens 108-113 29773200-10 2018 LiCl increased mitomycin C-induced cell shrinkage and PARP fragmentation suggesting induction of apoptosis in these cells. Lithium Chloride 0-4 collagen type XI alpha 2 chain Homo sapiens 54-58 29961297-16 2018 (3) On PSD 14, the mRNA expressions of Wnt1 and beta-catenin of rats in lithium chloride group and alprostadil group were significantly higher than those in simple scald group (q=65.40, 19.16, 66.79, 18.41, P<0.05), and the mRNA expressions of Wnt1 and beta-catenin of rats in simple scald group was significantly higher than those in sham scald group (t=14.86, 4.46, P<0.05). Lithium Chloride 72-88 Wnt family member 1 Rattus norvegicus 39-43 29961297-16 2018 (3) On PSD 14, the mRNA expressions of Wnt1 and beta-catenin of rats in lithium chloride group and alprostadil group were significantly higher than those in simple scald group (q=65.40, 19.16, 66.79, 18.41, P<0.05), and the mRNA expressions of Wnt1 and beta-catenin of rats in simple scald group was significantly higher than those in sham scald group (t=14.86, 4.46, P<0.05). Lithium Chloride 72-88 catenin beta 1 Rattus norvegicus 48-60 29961297-16 2018 (3) On PSD 14, the mRNA expressions of Wnt1 and beta-catenin of rats in lithium chloride group and alprostadil group were significantly higher than those in simple scald group (q=65.40, 19.16, 66.79, 18.41, P<0.05), and the mRNA expressions of Wnt1 and beta-catenin of rats in simple scald group was significantly higher than those in sham scald group (t=14.86, 4.46, P<0.05). Lithium Chloride 72-88 Wnt family member 1 Rattus norvegicus 247-251 29961297-16 2018 (3) On PSD 14, the mRNA expressions of Wnt1 and beta-catenin of rats in lithium chloride group and alprostadil group were significantly higher than those in simple scald group (q=65.40, 19.16, 66.79, 18.41, P<0.05), and the mRNA expressions of Wnt1 and beta-catenin of rats in simple scald group was significantly higher than those in sham scald group (t=14.86, 4.46, P<0.05). Lithium Chloride 72-88 catenin beta 1 Rattus norvegicus 256-268 30074215-0 2018 p38 MAPK is Crucial for Wnt1- and LiCl-Induced Epithelial Mesenchymal Transition. Lithium Chloride 34-38 mitogen-activated protein kinase 14 Homo sapiens 0-3 29946551-5 2018 The application of lithium chloride to muscle derived cells significantly increased the phosphorylation of GSK-3beta and thus inhibited its activity thus mimicking Wnt signaling. Lithium Chloride 19-35 glycogen synthase kinase 3 beta Sus scrofa 107-116 29946551-10 2018 This was done by inactivation of GSK-3beta by the use of Lithium Chloride. Lithium Chloride 57-73 glycogen synthase kinase 3 beta Sus scrofa 33-42 29546272-10 2018 However, a specific activator, namely, lithium chloride (LiCl), increased beta-catenin expression but had no evident influence on SATB1 expression. Lithium Chloride 39-55 catenin beta 1 Homo sapiens 74-86 29546272-10 2018 However, a specific activator, namely, lithium chloride (LiCl), increased beta-catenin expression but had no evident influence on SATB1 expression. Lithium Chloride 57-61 catenin beta 1 Homo sapiens 74-86 29754471-10 2018 Finally, addition of LiCl (Wnt/beta-catenin pathway activator) or XAV93920 (Wnt/beta-catenin pathway inhibitor) would cause remarkably altered E-cadherin, c-Myc, vimentin and snail expressions, as well as significantly changed transcriptional activity of beta-catenin/Tcf reporter plasmid (P < 0.05). Lithium Chloride 21-25 catenin beta 1 Homo sapiens 31-43 29231977-8 2018 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin signaling pathway, markedly attenuated overexpression BAK1-induced mitochondrial apoptosis by restoring the expression levels of Ser9-GSK3beta and beta-catenin. Lithium Chloride 13-29 catenin beta 1 Homo sapiens 58-70 29231977-8 2018 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin signaling pathway, markedly attenuated overexpression BAK1-induced mitochondrial apoptosis by restoring the expression levels of Ser9-GSK3beta and beta-catenin. Lithium Chloride 13-29 BCL2 antagonist/killer 1 Homo sapiens 125-129 29231977-8 2018 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin signaling pathway, markedly attenuated overexpression BAK1-induced mitochondrial apoptosis by restoring the expression levels of Ser9-GSK3beta and beta-catenin. Lithium Chloride 13-29 glycogen synthase kinase 3 beta Homo sapiens 200-213 29231977-8 2018 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin signaling pathway, markedly attenuated overexpression BAK1-induced mitochondrial apoptosis by restoring the expression levels of Ser9-GSK3beta and beta-catenin. Lithium Chloride 13-29 catenin beta 1 Homo sapiens 218-230 29231977-8 2018 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin signaling pathway, markedly attenuated overexpression BAK1-induced mitochondrial apoptosis by restoring the expression levels of Ser9-GSK3beta and beta-catenin. Lithium Chloride 31-35 catenin beta 1 Homo sapiens 58-70 29231977-8 2018 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin signaling pathway, markedly attenuated overexpression BAK1-induced mitochondrial apoptosis by restoring the expression levels of Ser9-GSK3beta and beta-catenin. Lithium Chloride 31-35 BCL2 antagonist/killer 1 Homo sapiens 125-129 29231977-8 2018 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin signaling pathway, markedly attenuated overexpression BAK1-induced mitochondrial apoptosis by restoring the expression levels of Ser9-GSK3beta and beta-catenin. Lithium Chloride 31-35 glycogen synthase kinase 3 beta Homo sapiens 200-213 29231977-8 2018 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin signaling pathway, markedly attenuated overexpression BAK1-induced mitochondrial apoptosis by restoring the expression levels of Ser9-GSK3beta and beta-catenin. Lithium Chloride 31-35 catenin beta 1 Homo sapiens 218-230 29754471-10 2018 Finally, addition of LiCl (Wnt/beta-catenin pathway activator) or XAV93920 (Wnt/beta-catenin pathway inhibitor) would cause remarkably altered E-cadherin, c-Myc, vimentin and snail expressions, as well as significantly changed transcriptional activity of beta-catenin/Tcf reporter plasmid (P < 0.05). Lithium Chloride 21-25 cadherin 1 Homo sapiens 143-153 29754471-10 2018 Finally, addition of LiCl (Wnt/beta-catenin pathway activator) or XAV93920 (Wnt/beta-catenin pathway inhibitor) would cause remarkably altered E-cadherin, c-Myc, vimentin and snail expressions, as well as significantly changed transcriptional activity of beta-catenin/Tcf reporter plasmid (P < 0.05). Lithium Chloride 21-25 MYC proto-oncogene, bHLH transcription factor Homo sapiens 155-160 29754471-10 2018 Finally, addition of LiCl (Wnt/beta-catenin pathway activator) or XAV93920 (Wnt/beta-catenin pathway inhibitor) would cause remarkably altered E-cadherin, c-Myc, vimentin and snail expressions, as well as significantly changed transcriptional activity of beta-catenin/Tcf reporter plasmid (P < 0.05). Lithium Chloride 21-25 vimentin Homo sapiens 162-170 29754471-10 2018 Finally, addition of LiCl (Wnt/beta-catenin pathway activator) or XAV93920 (Wnt/beta-catenin pathway inhibitor) would cause remarkably altered E-cadherin, c-Myc, vimentin and snail expressions, as well as significantly changed transcriptional activity of beta-catenin/Tcf reporter plasmid (P < 0.05). Lithium Chloride 21-25 snail family transcriptional repressor 1 Homo sapiens 175-180 29754471-10 2018 Finally, addition of LiCl (Wnt/beta-catenin pathway activator) or XAV93920 (Wnt/beta-catenin pathway inhibitor) would cause remarkably altered E-cadherin, c-Myc, vimentin and snail expressions, as well as significantly changed transcriptional activity of beta-catenin/Tcf reporter plasmid (P < 0.05). Lithium Chloride 21-25 hepatocyte nuclear factor 4 alpha Homo sapiens 268-271 29741888-4 2018 Oxidation of LCo(PEt3)2 with AgOTf in the presence of LiCl as a trapping nucleophile forms the unusual aggregate [LCo(PEt3)2Cl(LiOTf)2]2 held together by Li+ binding to very nucleophilic chloride on Co(III) and triflate binding to those Li+. Lithium Chloride 54-58 mitochondrially encoded cytochrome c oxidase III Homo sapiens 199-206 29655866-5 2018 GSK3beta mediated Nrf2 ubiquitination was confirmed by administration of GSK3beta inhibitor (LiCl; 60 mg/kg bwt.) Lithium Chloride 93-97 glycogen synthase kinase 3 beta Rattus norvegicus 0-8 29555592-10 2018 Conversely, the antioxidant effects of RosA could be blocked by Akt inhibitors LY294002, GSK-3beta inhibitor LiCl, Nrf2 shRNA, or Fyn shRNA in Abeta-challenged PC12 cells. Lithium Chloride 109-113 glycogen synthase kinase 3 beta Rattus norvegicus 89-98 29655866-5 2018 GSK3beta mediated Nrf2 ubiquitination was confirmed by administration of GSK3beta inhibitor (LiCl; 60 mg/kg bwt.) Lithium Chloride 93-97 NFE2 like bZIP transcription factor 2 Rattus norvegicus 18-22 29655866-5 2018 GSK3beta mediated Nrf2 ubiquitination was confirmed by administration of GSK3beta inhibitor (LiCl; 60 mg/kg bwt.) Lithium Chloride 93-97 glycogen synthase kinase 3 beta Rattus norvegicus 73-81 29891461-8 2018 LiCl, an inhibitor of GSK-3beta, attenuated HG-induced ERS and significantly lowered the expression levels of GRP78 and CHOP (P<0.01). Lithium Chloride 0-4 glycogen synthase kinase 3 beta Homo sapiens 22-31 29891449-0 2018 [Lithium chloride arrests HK-2 cell cycle in G2 phase through AKT/GSK-3beta signal pathway]. Lithium Chloride 1-17 AKT serine/threonine kinase 1 Homo sapiens 62-65 29891461-8 2018 LiCl, an inhibitor of GSK-3beta, attenuated HG-induced ERS and significantly lowered the expression levels of GRP78 and CHOP (P<0.01). Lithium Chloride 0-4 heat shock protein family A (Hsp70) member 5 Homo sapiens 110-115 29891449-0 2018 [Lithium chloride arrests HK-2 cell cycle in G2 phase through AKT/GSK-3beta signal pathway]. Lithium Chloride 1-17 glycogen synthase kinase 3 beta Homo sapiens 66-75 29891449-5 2018 The expressions of cyclin B1, CDK1, p-GSK-3beta, and beta-catenin increased and the expression of p-AKT decreased significantly in the cells as LiCl treatment time and concentration increased. Lithium Chloride 144-148 cyclin B1 Homo sapiens 19-28 29891461-8 2018 LiCl, an inhibitor of GSK-3beta, attenuated HG-induced ERS and significantly lowered the expression levels of GRP78 and CHOP (P<0.01). Lithium Chloride 0-4 DNA damage inducible transcript 3 Homo sapiens 120-124 29891449-5 2018 The expressions of cyclin B1, CDK1, p-GSK-3beta, and beta-catenin increased and the expression of p-AKT decreased significantly in the cells as LiCl treatment time and concentration increased. Lithium Chloride 144-148 glycogen synthase kinase 3 beta Homo sapiens 38-47 29891449-5 2018 The expressions of cyclin B1, CDK1, p-GSK-3beta, and beta-catenin increased and the expression of p-AKT decreased significantly in the cells as LiCl treatment time and concentration increased. Lithium Chloride 144-148 catenin beta 1 Homo sapiens 53-65 29700285-9 2018 Furthermore, inhibition of GSK3beta by LiCl abolished the suppression of cell growth, migration, and invasion mediated by HOXA4. Lithium Chloride 39-43 glycogen synthase kinase 3 beta Mus musculus 27-35 29891449-5 2018 The expressions of cyclin B1, CDK1, p-GSK-3beta, and beta-catenin increased and the expression of p-AKT decreased significantly in the cells as LiCl treatment time and concentration increased. Lithium Chloride 144-148 AKT serine/threonine kinase 1 Homo sapiens 100-103 29891449-6 2018 CONCLUSION: LiCl may cause HK-2 cell cycle arrest in G2 phase through activation of the AKT/GSK-3beta signaling pathway. Lithium Chloride 12-16 AKT serine/threonine kinase 1 Homo sapiens 88-91 29891449-6 2018 CONCLUSION: LiCl may cause HK-2 cell cycle arrest in G2 phase through activation of the AKT/GSK-3beta signaling pathway. Lithium Chloride 12-16 glycogen synthase kinase 3 beta Homo sapiens 92-101 29545118-0 2018 Cognitive benefits of lithium chloride in APP/PS1 mice are associated with enhanced brain clearance of beta-amyloid. Lithium Chloride 22-38 presenilin 1 Mus musculus 46-49 29545118-2 2018 Lithium chloride (LiCl) reduces brain beta-amyloid (Abeta) levels, and the brain clearance of Abeta is reduced in AD. Lithium Chloride 0-16 amyloid beta (A4) precursor protein Mus musculus 52-57 29545118-2 2018 Lithium chloride (LiCl) reduces brain beta-amyloid (Abeta) levels, and the brain clearance of Abeta is reduced in AD. Lithium Chloride 18-22 amyloid beta (A4) precursor protein Mus musculus 52-57 29545118-3 2018 Therefore, the purpose of this study was to assess whether the cognitive benefits of LiCl are associated with enhanced brain clearance of exogenously-administered Abeta. Lithium Chloride 85-89 amyloid beta (A4) precursor protein Mus musculus 163-168 29545118-5 2018 LiCl exhibited a 31% increase in the brain clearance of 125I-Abeta42 over 10 min, which was associated with a 1.6-fold increase in brain microvascular expression of the blood-brain barrier efflux transporter low density lipoprotein receptor-related protein 1 (LRP1) and increased cerebrospinal fluid (CSF) bulk-flow. Lithium Chloride 0-4 low density lipoprotein receptor-related protein 1 Mus musculus 260-264 29545118-7 2018 LiCl treatment restored the long-term spatial memory deficit observed in APP/PS1 mice as assessed by the water maze (back to similar levels of escape latency as WT mice), but the short-term memory deficit remained unaffected by LiCl treatment. Lithium Chloride 0-4 presenilin 1 Mus musculus 77-80 29545118-8 2018 While LiCl did not affect plaque-associated Abeta42, soluble Abeta42 levels were reduced by 49.9% in APP/PS1 mice receiving LiCl. Lithium Chloride 124-128 presenilin 1 Mus musculus 105-108 29545118-9 2018 The brain clearance of 125I-Abeta42 decreased by 27.8% in APP/PS1 mice, relative to WT mice, however, LiCl treatment restored brain 125I-Abeta42 clearance in APP/PS1 mice to a rate similar to that observed in WT mice. Lithium Chloride 102-106 presenilin 1 Mus musculus 62-65 29545118-9 2018 The brain clearance of 125I-Abeta42 decreased by 27.8% in APP/PS1 mice, relative to WT mice, however, LiCl treatment restored brain 125I-Abeta42 clearance in APP/PS1 mice to a rate similar to that observed in WT mice. Lithium Chloride 102-106 presenilin 1 Mus musculus 162-165 29545118-10 2018 These findings suggest that the cognitive benefits and brain Abeta42 lowering effects of LiCl are associated with enhanced brain clearance of Abeta42, possibly via brain microvascular LRP1 upregulation and increased CSF bulk-flow, identifying a novel mechanism of protection by LiCl for the treatment of AD. Lithium Chloride 89-93 low density lipoprotein receptor-related protein 1 Mus musculus 184-188 29700285-9 2018 Furthermore, inhibition of GSK3beta by LiCl abolished the suppression of cell growth, migration, and invasion mediated by HOXA4. Lithium Chloride 39-43 homeobox A4 Mus musculus 122-127 29358311-11 2018 All these effects were similar to 10 ng/ml DKK-1 and could be attenuated by 10 mM LiCl. Lithium Chloride 82-86 dickkopf WNT signaling pathway inhibitor 1 Homo sapiens 43-48 29506051-5 2018 By analyzing a P7 rat model of cerebral HI and an in vitro ischemic (oxygen glucose deprivation) model, we found that GSK-3beta inhibitors (GSK-3beta siRNA or lithium chloride) activated mTORC1 signaling, leading to increased expression of synaptic proteins, including synapsin 1, PSD95, and GluR1, and the microtubule-associated protein Tau and decreased expression of the axonal injury-associated protein amyloid precursor protein. Lithium Chloride 159-175 glycogen synthase kinase 3 beta Rattus norvegicus 118-127 29506051-5 2018 By analyzing a P7 rat model of cerebral HI and an in vitro ischemic (oxygen glucose deprivation) model, we found that GSK-3beta inhibitors (GSK-3beta siRNA or lithium chloride) activated mTORC1 signaling, leading to increased expression of synaptic proteins, including synapsin 1, PSD95, and GluR1, and the microtubule-associated protein Tau and decreased expression of the axonal injury-associated protein amyloid precursor protein. Lithium Chloride 159-175 CREB regulated transcription coactivator 1 Mus musculus 187-193 29506051-5 2018 By analyzing a P7 rat model of cerebral HI and an in vitro ischemic (oxygen glucose deprivation) model, we found that GSK-3beta inhibitors (GSK-3beta siRNA or lithium chloride) activated mTORC1 signaling, leading to increased expression of synaptic proteins, including synapsin 1, PSD95, and GluR1, and the microtubule-associated protein Tau and decreased expression of the axonal injury-associated protein amyloid precursor protein. Lithium Chloride 159-175 synapsin I Rattus norvegicus 269-279 29506051-5 2018 By analyzing a P7 rat model of cerebral HI and an in vitro ischemic (oxygen glucose deprivation) model, we found that GSK-3beta inhibitors (GSK-3beta siRNA or lithium chloride) activated mTORC1 signaling, leading to increased expression of synaptic proteins, including synapsin 1, PSD95, and GluR1, and the microtubule-associated protein Tau and decreased expression of the axonal injury-associated protein amyloid precursor protein. Lithium Chloride 159-175 discs large MAGUK scaffold protein 4 Rattus norvegicus 281-286 29506051-5 2018 By analyzing a P7 rat model of cerebral HI and an in vitro ischemic (oxygen glucose deprivation) model, we found that GSK-3beta inhibitors (GSK-3beta siRNA or lithium chloride) activated mTORC1 signaling, leading to increased expression of synaptic proteins, including synapsin 1, PSD95, and GluR1, and the microtubule-associated protein Tau and decreased expression of the axonal injury-associated protein amyloid precursor protein. Lithium Chloride 159-175 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 292-297 29506051-5 2018 By analyzing a P7 rat model of cerebral HI and an in vitro ischemic (oxygen glucose deprivation) model, we found that GSK-3beta inhibitors (GSK-3beta siRNA or lithium chloride) activated mTORC1 signaling, leading to increased expression of synaptic proteins, including synapsin 1, PSD95, and GluR1, and the microtubule-associated protein Tau and decreased expression of the axonal injury-associated protein amyloid precursor protein. Lithium Chloride 159-175 microtubule-associated protein tau Rattus norvegicus 307-341 29772867-8 2018 As for the Bcl-2 protein expression, black control group has a level of 0.081+-0.003;7 d and 14 d postoperatively, the level in Licl group was 0.151+-0.003, 0.163+-0.003 and in NS group, 0.143+-0.003, 0.154+-0.002, respectively. Lithium Chloride 128-132 BCL2, apoptosis regulator Rattus norvegicus 11-16 29772867-9 2018 Licl group showed significantly increased Bcl-2 protein expression(P<0.05). Lithium Chloride 0-4 BCL2, apoptosis regulator Rattus norvegicus 42-47 29772867-10 2018 As for the Bax protein expression, black control group showed a level of 0.071+-0.003; 7 d and 14 d postoperatively, the level in Licl group was 0.121+-0.002, 0.106+-0.002 and in NS group was 0.126+-0.001, 0.120+-0.002, respectively. Lithium Chloride 130-134 BCL2 associated X, apoptosis regulator Rattus norvegicus 11-14 29772867-14 2018 CONCLUSIONS: Licl can promote the Bcl-2 protein expression and inhibit the Bax proteins expression in nerve cells of rat after SCI, thereby playing a role in the inhibition of nerve cell apoptosis. Lithium Chloride 13-17 BCL2, apoptosis regulator Rattus norvegicus 34-39 29772867-14 2018 CONCLUSIONS: Licl can promote the Bcl-2 protein expression and inhibit the Bax proteins expression in nerve cells of rat after SCI, thereby playing a role in the inhibition of nerve cell apoptosis. Lithium Chloride 13-17 BCL2 associated X, apoptosis regulator Rattus norvegicus 75-78 29243047-8 2018 In addition, we found that LiCl-mediated up-regulation of beta-catenin in HNSCC-derived cells led to cisplatin resistance, evasion of apoptosis, enhanced DNA repair and enhanced migration. Lithium Chloride 27-31 catenin beta 1 Homo sapiens 58-70 28921615-8 2018 Both DEHP and MEHP significantly increased the ratios of phosphorylated beta-catenin/beta-catenin and inhibited osteoblastogenesis, which could be reversed by Wnt activator lithium chloride and PPARgamma inhibitor T0070907. Lithium Chloride 173-189 catenin (cadherin associated protein), beta 1 Mus musculus 72-84 28921615-8 2018 Both DEHP and MEHP significantly increased the ratios of phosphorylated beta-catenin/beta-catenin and inhibited osteoblastogenesis, which could be reversed by Wnt activator lithium chloride and PPARgamma inhibitor T0070907. Lithium Chloride 173-189 catenin (cadherin associated protein), beta 1 Mus musculus 85-97 28921615-8 2018 Both DEHP and MEHP significantly increased the ratios of phosphorylated beta-catenin/beta-catenin and inhibited osteoblastogenesis, which could be reversed by Wnt activator lithium chloride and PPARgamma inhibitor T0070907. Lithium Chloride 173-189 wingless-type MMTV integration site family, member 1 Mus musculus 159-162 29756516-5 2018 LiCl treatment produced less macrosialin (ED1) expression and axonal degeneration in tibial nerve after NSC injection. Lithium Chloride 0-4 Cd68 molecule Rattus norvegicus 29-40 29301784-9 2018 Lowering inositol 1,4,5-trisphosphate levels with phospholipase C inhibitor or lithium chloride suppressed phenylephrine activation of endothelial TRPV4 sparklets. Lithium Chloride 79-95 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 147-152 29136173-9 2018 Addition of LiCl, a GSK3beta inhibitor, significantly increased osteogenic differentiation in FH-pMSCs, suggesting a relationship between the microenvironment and regulation of stem cell behaviour in ONFH. Lithium Chloride 12-16 glycogen synthase kinase 3 beta Homo sapiens 20-28 29407584-4 2018 In the present study, we examined the effects of MG-132 (a proteasome inhibitor), LiCl (a glycogen synthase kinase-3 inhibitor) and/or TRAIL on pro-apoptotic Bcl-2 family proteins such as Bim and Bid. Lithium Chloride 82-86 BCL2 apoptosis regulator Homo sapiens 158-163 28867214-0 2018 Lithium chloride inhibits StAR and progesterone production through GSK-3beta and ERK1/2 signaling pathways in human granulosa-lutein cells. Lithium Chloride 0-16 steroidogenic acute regulatory protein Homo sapiens 26-30 29435081-7 2018 But, that was reversed by the treatment with lithium chloride (LiCl), by which the canonical Wnt/beta-catenin pathway could be activated. Lithium Chloride 45-61 catenin beta 1 Homo sapiens 97-109 29435081-7 2018 But, that was reversed by the treatment with lithium chloride (LiCl), by which the canonical Wnt/beta-catenin pathway could be activated. Lithium Chloride 63-67 catenin beta 1 Homo sapiens 97-109 29472597-5 2018 During in vitro aging up to 12 h, upregulating autophagy with rapamycin or lithium chloride decreased activation susceptibility, cytoplasmic calcium, p62 contents, oxidative stress, caspase-3 activation and cytoplasmic fragmentation while increasing developmental competence, LC3-II contents, LC3-II/I ratio, mitochondrial membrane potential, spindle/chromosome integrity and normal cortical granule distribution. Lithium Chloride 75-91 microtubule-associated protein 1 light chain 3 alpha Mus musculus 276-279 29531810-8 2018 Furthermore, addition of lithium chloride led to MET which was accompanied by increases in epithelial (CDH1) and tubular (ENPEP) markers and downregulation of renal progenitor (SIX2, EYA1, CD133) and mesenchymal markers (HGF, CD24). Lithium Chloride 25-41 cadherin 1 Homo sapiens 103-107 29531810-8 2018 Furthermore, addition of lithium chloride led to MET which was accompanied by increases in epithelial (CDH1) and tubular (ENPEP) markers and downregulation of renal progenitor (SIX2, EYA1, CD133) and mesenchymal markers (HGF, CD24). Lithium Chloride 25-41 glutamyl aminopeptidase Homo sapiens 122-127 29531810-8 2018 Furthermore, addition of lithium chloride led to MET which was accompanied by increases in epithelial (CDH1) and tubular (ENPEP) markers and downregulation of renal progenitor (SIX2, EYA1, CD133) and mesenchymal markers (HGF, CD24). Lithium Chloride 25-41 SIX homeobox 2 Homo sapiens 177-181 29531810-8 2018 Furthermore, addition of lithium chloride led to MET which was accompanied by increases in epithelial (CDH1) and tubular (ENPEP) markers and downregulation of renal progenitor (SIX2, EYA1, CD133) and mesenchymal markers (HGF, CD24). Lithium Chloride 25-41 EYA transcriptional coactivator and phosphatase 1 Homo sapiens 183-187 29531810-8 2018 Furthermore, addition of lithium chloride led to MET which was accompanied by increases in epithelial (CDH1) and tubular (ENPEP) markers and downregulation of renal progenitor (SIX2, EYA1, CD133) and mesenchymal markers (HGF, CD24). Lithium Chloride 25-41 prominin 1 Homo sapiens 189-194 29531810-8 2018 Furthermore, addition of lithium chloride led to MET which was accompanied by increases in epithelial (CDH1) and tubular (ENPEP) markers and downregulation of renal progenitor (SIX2, EYA1, CD133) and mesenchymal markers (HGF, CD24). Lithium Chloride 25-41 hepatocyte growth factor Homo sapiens 221-224 29531810-8 2018 Furthermore, addition of lithium chloride led to MET which was accompanied by increases in epithelial (CDH1) and tubular (ENPEP) markers and downregulation of renal progenitor (SIX2, EYA1, CD133) and mesenchymal markers (HGF, CD24). Lithium Chloride 25-41 CD24 molecule Homo sapiens 226-230 29531810-9 2018 Prior to phenotypic changes, lithium chloride altered Wnt signalling with elevations in AXIN2, GSK3beta phosphorylation and beta-catenin. Lithium Chloride 29-45 axin 2 Homo sapiens 88-93 29531810-9 2018 Prior to phenotypic changes, lithium chloride altered Wnt signalling with elevations in AXIN2, GSK3beta phosphorylation and beta-catenin. Lithium Chloride 29-45 glycogen synthase kinase 3 beta Homo sapiens 95-103 29531810-9 2018 Prior to phenotypic changes, lithium chloride altered Wnt signalling with elevations in AXIN2, GSK3beta phosphorylation and beta-catenin. Lithium Chloride 29-45 catenin beta 1 Homo sapiens 124-136 29341468-14 2018 Reactivation of Wnt/beta-catenin pathway by LiCl can reverse the inhibiting effect of Barx2. Lithium Chloride 44-48 catenin beta 1 Homo sapiens 20-32 29341468-14 2018 Reactivation of Wnt/beta-catenin pathway by LiCl can reverse the inhibiting effect of Barx2. Lithium Chloride 44-48 BarH like homeobox 2 Homo sapiens 86-91 29472597-5 2018 During in vitro aging up to 12 h, upregulating autophagy with rapamycin or lithium chloride decreased activation susceptibility, cytoplasmic calcium, p62 contents, oxidative stress, caspase-3 activation and cytoplasmic fragmentation while increasing developmental competence, LC3-II contents, LC3-II/I ratio, mitochondrial membrane potential, spindle/chromosome integrity and normal cortical granule distribution. Lithium Chloride 75-91 nucleoporin 62 Mus musculus 150-153 29472597-5 2018 During in vitro aging up to 12 h, upregulating autophagy with rapamycin or lithium chloride decreased activation susceptibility, cytoplasmic calcium, p62 contents, oxidative stress, caspase-3 activation and cytoplasmic fragmentation while increasing developmental competence, LC3-II contents, LC3-II/I ratio, mitochondrial membrane potential, spindle/chromosome integrity and normal cortical granule distribution. Lithium Chloride 75-91 caspase 3 Mus musculus 182-191 28867214-0 2018 Lithium chloride inhibits StAR and progesterone production through GSK-3beta and ERK1/2 signaling pathways in human granulosa-lutein cells. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Homo sapiens 67-76 28867214-0 2018 Lithium chloride inhibits StAR and progesterone production through GSK-3beta and ERK1/2 signaling pathways in human granulosa-lutein cells. Lithium Chloride 0-16 mitogen-activated protein kinase 3 Homo sapiens 81-87 28867214-5 2018 Our results showed that LiCl significantly down-regulated the steroidogenic acute regulatory protein (StAR) expression and subsequent progesterone production in hGL cells. Lithium Chloride 24-28 steroidogenic acute regulatory protein Homo sapiens 102-106 28867214-5 2018 Our results showed that LiCl significantly down-regulated the steroidogenic acute regulatory protein (StAR) expression and subsequent progesterone production in hGL cells. Lithium Chloride 24-28 LLGL scribble cell polarity complex component 2 Homo sapiens 161-164 28867214-6 2018 Additionally, LiCl induced the phosphorylation of GSK-3beta and ERK1/2 but not AKT or CREB. Lithium Chloride 14-18 glycogen synthase kinase 3 beta Homo sapiens 50-59 28867214-6 2018 Additionally, LiCl induced the phosphorylation of GSK-3beta and ERK1/2 but not AKT or CREB. Lithium Chloride 14-18 mitogen-activated protein kinase 3 Homo sapiens 64-70 28867214-7 2018 Knockdown of endogenous GSK-3beta or inhibition of ERK1/2 partially reversed LiCl-induced down-regulation of StAR. Lithium Chloride 77-81 glycogen synthase kinase 3 beta Homo sapiens 24-33 28867214-7 2018 Knockdown of endogenous GSK-3beta or inhibition of ERK1/2 partially reversed LiCl-induced down-regulation of StAR. Lithium Chloride 77-81 mitogen-activated protein kinase 3 Homo sapiens 51-57 28867214-7 2018 Knockdown of endogenous GSK-3beta or inhibition of ERK1/2 partially reversed LiCl-induced down-regulation of StAR. Lithium Chloride 77-81 steroidogenic acute regulatory protein Homo sapiens 109-113 28867214-8 2018 Furthermore, by using dual inhibition approaches, the results showed that both GSK-3beta and ERK1/2 signaling mediated the regulatory effect of LiCl on StAR expression. Lithium Chloride 144-148 glycogen synthase kinase 3 beta Homo sapiens 79-88 28867214-8 2018 Furthermore, by using dual inhibition approaches, the results showed that both GSK-3beta and ERK1/2 signaling mediated the regulatory effect of LiCl on StAR expression. Lithium Chloride 144-148 mitogen-activated protein kinase 3 Homo sapiens 93-99 28867214-8 2018 Furthermore, by using dual inhibition approaches, the results showed that both GSK-3beta and ERK1/2 signaling mediated the regulatory effect of LiCl on StAR expression. Lithium Chloride 144-148 steroidogenic acute regulatory protein Homo sapiens 152-156 28776719-4 2018 Here, it was observed that activation of endogenous canonical Wnt signaling with LiCl, which decreased beta-catenin phosphorylation, leads to a decrease in hMSC proliferation. Lithium Chloride 81-85 catenin beta 1 Homo sapiens 103-115 28621459-7 2018 Moreover, the reduction of nuclear beta-catenin amount and decreased expression of TCF1 and Runx2 were significantly reversed in MACF1-KD cells when treated with lithium chloride, an agonist for beta-catenin by inhibiting GSK-3beta activity. Lithium Chloride 162-178 catenin (cadherin associated protein), beta 1 Mus musculus 35-47 28886972-6 2018 As expected, blockage of GSK-3beta activity with a GSK-3beta inhibitor lithium chloride (LiCl) or activation of Akt signaling with an Akt agonist insulin-like growth factor-1 (IGF-1) could inhibit HQ-induced activation of GSK-3beta as well as hematotoxicity. Lithium Chloride 71-87 glycogen synthase kinase 3 beta Homo sapiens 25-34 28621459-7 2018 Moreover, the reduction of nuclear beta-catenin amount and decreased expression of TCF1 and Runx2 were significantly reversed in MACF1-KD cells when treated with lithium chloride, an agonist for beta-catenin by inhibiting GSK-3beta activity. Lithium Chloride 162-178 transcription factor 7, T cell specific Mus musculus 83-87 28621459-7 2018 Moreover, the reduction of nuclear beta-catenin amount and decreased expression of TCF1 and Runx2 were significantly reversed in MACF1-KD cells when treated with lithium chloride, an agonist for beta-catenin by inhibiting GSK-3beta activity. Lithium Chloride 162-178 runt related transcription factor 2 Mus musculus 92-97 28621459-7 2018 Moreover, the reduction of nuclear beta-catenin amount and decreased expression of TCF1 and Runx2 were significantly reversed in MACF1-KD cells when treated with lithium chloride, an agonist for beta-catenin by inhibiting GSK-3beta activity. Lithium Chloride 162-178 microtubule-actin crosslinking factor 1 Mus musculus 129-134 28621459-7 2018 Moreover, the reduction of nuclear beta-catenin amount and decreased expression of TCF1 and Runx2 were significantly reversed in MACF1-KD cells when treated with lithium chloride, an agonist for beta-catenin by inhibiting GSK-3beta activity. Lithium Chloride 162-178 catenin (cadherin associated protein), beta 1 Mus musculus 195-207 28621459-7 2018 Moreover, the reduction of nuclear beta-catenin amount and decreased expression of TCF1 and Runx2 were significantly reversed in MACF1-KD cells when treated with lithium chloride, an agonist for beta-catenin by inhibiting GSK-3beta activity. Lithium Chloride 162-178 glycogen synthase kinase 3 beta Mus musculus 222-231 28886972-6 2018 As expected, blockage of GSK-3beta activity with a GSK-3beta inhibitor lithium chloride (LiCl) or activation of Akt signaling with an Akt agonist insulin-like growth factor-1 (IGF-1) could inhibit HQ-induced activation of GSK-3beta as well as hematotoxicity. Lithium Chloride 71-87 glycogen synthase kinase 3 beta Homo sapiens 51-60 28886972-6 2018 As expected, blockage of GSK-3beta activity with a GSK-3beta inhibitor lithium chloride (LiCl) or activation of Akt signaling with an Akt agonist insulin-like growth factor-1 (IGF-1) could inhibit HQ-induced activation of GSK-3beta as well as hematotoxicity. Lithium Chloride 89-93 glycogen synthase kinase 3 beta Homo sapiens 25-34 28886972-6 2018 As expected, blockage of GSK-3beta activity with a GSK-3beta inhibitor lithium chloride (LiCl) or activation of Akt signaling with an Akt agonist insulin-like growth factor-1 (IGF-1) could inhibit HQ-induced activation of GSK-3beta as well as hematotoxicity. Lithium Chloride 71-87 glycogen synthase kinase 3 beta Homo sapiens 51-60 29763908-13 2018 Furthermore, treatment of Cx43-knockdown cells with lithium chloride (LiCl), a GSK-3beta inhibitor, reduced osteogenic differentiation and decreased GSK-3beta levels, as well as partially rescued levels of both total and activated beta-catenin. Lithium Chloride 52-68 gap junction protein alpha 1 Homo sapiens 26-30 29391808-10 2018 Activation of Wnt/beta-Catenin pathway by Licl treatment promoted EMT and enhanced chemoresistance to TMZ compared with TMZ+H19 shRNA group. Lithium Chloride 42-46 catenin beta 1 Homo sapiens 18-30 30257243-8 2018 In addition, Oil Red O staining was performed to investigate lipid droplet formation during adipogenesis induction with or without LiCl, a potent activator of TCF/beta-catenin-dependent transcription. Lithium Chloride 131-135 hepatocyte nuclear factor 4 alpha Homo sapiens 159-162 30257243-8 2018 In addition, Oil Red O staining was performed to investigate lipid droplet formation during adipogenesis induction with or without LiCl, a potent activator of TCF/beta-catenin-dependent transcription. Lithium Chloride 131-135 catenin beta 1 Homo sapiens 163-175 30415260-13 2018 Apoptosis was partly reversed after adding the Wnt signaling activator Wnt3a and lithium chloride (LiCl, a GSK-3beta inhibitor). Lithium Chloride 81-97 Wnt family member 2 Rattus norvegicus 47-50 30415260-13 2018 Apoptosis was partly reversed after adding the Wnt signaling activator Wnt3a and lithium chloride (LiCl, a GSK-3beta inhibitor). Lithium Chloride 81-97 glycogen synthase kinase 3 beta Rattus norvegicus 107-116 30415260-13 2018 Apoptosis was partly reversed after adding the Wnt signaling activator Wnt3a and lithium chloride (LiCl, a GSK-3beta inhibitor). Lithium Chloride 99-103 Wnt family member 2 Rattus norvegicus 47-50 30415260-13 2018 Apoptosis was partly reversed after adding the Wnt signaling activator Wnt3a and lithium chloride (LiCl, a GSK-3beta inhibitor). Lithium Chloride 99-103 glycogen synthase kinase 3 beta Rattus norvegicus 107-116 29705802-8 2018 Additionally, LiCl treatment increased SOA activity, GSH-Px levels, and GSK-3beta-Ser9 phosphorylation; decreased MDA accumulation in the striatum and GSK-3beta mRNA levels; as well as increased beta-catenin and cyclinD1 mRNA and protein levels in 6-OHDA-treated PC12 cells. Lithium Chloride 14-18 glycogen synthase kinase 3 beta Rattus norvegicus 72-81 29705802-8 2018 Additionally, LiCl treatment increased SOA activity, GSH-Px levels, and GSK-3beta-Ser9 phosphorylation; decreased MDA accumulation in the striatum and GSK-3beta mRNA levels; as well as increased beta-catenin and cyclinD1 mRNA and protein levels in 6-OHDA-treated PC12 cells. Lithium Chloride 14-18 glycogen synthase kinase 3 beta Rattus norvegicus 151-160 29705802-8 2018 Additionally, LiCl treatment increased SOA activity, GSH-Px levels, and GSK-3beta-Ser9 phosphorylation; decreased MDA accumulation in the striatum and GSK-3beta mRNA levels; as well as increased beta-catenin and cyclinD1 mRNA and protein levels in 6-OHDA-treated PC12 cells. Lithium Chloride 14-18 catenin beta 1 Rattus norvegicus 195-207 29705802-8 2018 Additionally, LiCl treatment increased SOA activity, GSH-Px levels, and GSK-3beta-Ser9 phosphorylation; decreased MDA accumulation in the striatum and GSK-3beta mRNA levels; as well as increased beta-catenin and cyclinD1 mRNA and protein levels in 6-OHDA-treated PC12 cells. Lithium Chloride 14-18 cyclin D1 Rattus norvegicus 212-220 29274777-7 2018 LiCl significantly induced the extent of autophagic flux after SCI by increasing LC3-II and ATG-5 levels, and abolishing p62 accumulation. Lithium Chloride 0-4 autophagy related 5 Rattus norvegicus 92-97 29274777-7 2018 LiCl significantly induced the extent of autophagic flux after SCI by increasing LC3-II and ATG-5 levels, and abolishing p62 accumulation. Lithium Chloride 0-4 KH RNA binding domain containing, signal transduction associated 1 Rattus norvegicus 121-124 29632640-6 2018 LiCl treatment, Wnt3a treatment or beta-catenin overexpression enhanced the transcription of MRTF-A gene. Lithium Chloride 0-4 myocardin related transcription factor A Homo sapiens 93-99 29099417-10 2018 CacyBP/SIP overexpression led to retarded proliferation, G1 arrest, and beta-catenin reduction, which could be abolished by lithium chloride, beta-catenin activator, and further enhanced by the Wnt inhibitor XAV-939. Lithium Chloride 124-140 calcyclin binding protein Homo sapiens 0-6 29099417-10 2018 CacyBP/SIP overexpression led to retarded proliferation, G1 arrest, and beta-catenin reduction, which could be abolished by lithium chloride, beta-catenin activator, and further enhanced by the Wnt inhibitor XAV-939. Lithium Chloride 124-140 calcyclin binding protein Homo sapiens 7-10 29099417-10 2018 CacyBP/SIP overexpression led to retarded proliferation, G1 arrest, and beta-catenin reduction, which could be abolished by lithium chloride, beta-catenin activator, and further enhanced by the Wnt inhibitor XAV-939. Lithium Chloride 124-140 catenin beta 1 Homo sapiens 72-84 29663821-6 2018 RESULTS: LiCl has shown to increase survival rate of BMSCs under serum deprivation conditions through autophagy induction (reduced P62 and increased LC3II) and apoptosis inhibition (expression of XIAP), so that the cell survival rate, after 12 hours, was 29 %, 59 %, 83 %, 74 %, 49 % for the groups, which received 0, 1, 5, 10, 20 millimolar of LiCl, respectively, as compared to the control group. Lithium Chloride 9-13 X-linked inhibitor of apoptosis Homo sapiens 196-200 29763908-13 2018 Furthermore, treatment of Cx43-knockdown cells with lithium chloride (LiCl), a GSK-3beta inhibitor, reduced osteogenic differentiation and decreased GSK-3beta levels, as well as partially rescued levels of both total and activated beta-catenin. Lithium Chloride 52-68 glycogen synthase kinase 3 beta Homo sapiens 79-88 29763908-13 2018 Furthermore, treatment of Cx43-knockdown cells with lithium chloride (LiCl), a GSK-3beta inhibitor, reduced osteogenic differentiation and decreased GSK-3beta levels, as well as partially rescued levels of both total and activated beta-catenin. Lithium Chloride 52-68 glycogen synthase kinase 3 beta Homo sapiens 149-158 29763908-13 2018 Furthermore, treatment of Cx43-knockdown cells with lithium chloride (LiCl), a GSK-3beta inhibitor, reduced osteogenic differentiation and decreased GSK-3beta levels, as well as partially rescued levels of both total and activated beta-catenin. Lithium Chloride 52-68 catenin beta 1 Homo sapiens 231-243 29763908-13 2018 Furthermore, treatment of Cx43-knockdown cells with lithium chloride (LiCl), a GSK-3beta inhibitor, reduced osteogenic differentiation and decreased GSK-3beta levels, as well as partially rescued levels of both total and activated beta-catenin. Lithium Chloride 70-74 gap junction protein alpha 1 Homo sapiens 26-30 29763908-13 2018 Furthermore, treatment of Cx43-knockdown cells with lithium chloride (LiCl), a GSK-3beta inhibitor, reduced osteogenic differentiation and decreased GSK-3beta levels, as well as partially rescued levels of both total and activated beta-catenin. Lithium Chloride 70-74 glycogen synthase kinase 3 beta Homo sapiens 79-88 29763908-13 2018 Furthermore, treatment of Cx43-knockdown cells with lithium chloride (LiCl), a GSK-3beta inhibitor, reduced osteogenic differentiation and decreased GSK-3beta levels, as well as partially rescued levels of both total and activated beta-catenin. Lithium Chloride 70-74 glycogen synthase kinase 3 beta Homo sapiens 149-158 29763908-13 2018 Furthermore, treatment of Cx43-knockdown cells with lithium chloride (LiCl), a GSK-3beta inhibitor, reduced osteogenic differentiation and decreased GSK-3beta levels, as well as partially rescued levels of both total and activated beta-catenin. Lithium Chloride 70-74 catenin beta 1 Homo sapiens 231-243 31966540-8 2017 But, that was reversed by the treatment with LiCl (lithium chloride) which could activate canonical Wnt/beta-catenin signaling pathway. Lithium Chloride 45-49 catenin beta 1 Homo sapiens 104-116 28081383-7 2018 With LiCl treatment, the level of P-GSK3-beta in iris-ciliary body was upregulated and the expression of NF-kappaB p65 was significantly suppressed during EIU. Lithium Chloride 5-9 glycogen synthase kinase 3 beta Rattus norvegicus 36-45 28081383-7 2018 With LiCl treatment, the level of P-GSK3-beta in iris-ciliary body was upregulated and the expression of NF-kappaB p65 was significantly suppressed during EIU. Lithium Chloride 5-9 synaptotagmin 1 Rattus norvegicus 115-118 28367588-1 2017 BACKGROUND AND OBJECTIVES: Lithium chloride (LiCl) has been shown to improve the tightness of brain endothelial cell monolayers in vitro by inhibition of the GSK-3beta enzyme, activation of the Wnt/beta-catenin pathway and regulation of tight junction (TJ) protein expression. Lithium Chloride 27-43 glycogen synthase kinase 3 beta Homo sapiens 158-167 28367588-1 2017 BACKGROUND AND OBJECTIVES: Lithium chloride (LiCl) has been shown to improve the tightness of brain endothelial cell monolayers in vitro by inhibition of the GSK-3beta enzyme, activation of the Wnt/beta-catenin pathway and regulation of tight junction (TJ) protein expression. Lithium Chloride 27-43 catenin beta 1 Homo sapiens 198-210 28367588-1 2017 BACKGROUND AND OBJECTIVES: Lithium chloride (LiCl) has been shown to improve the tightness of brain endothelial cell monolayers in vitro by inhibition of the GSK-3beta enzyme, activation of the Wnt/beta-catenin pathway and regulation of tight junction (TJ) protein expression. Lithium Chloride 45-49 glycogen synthase kinase 3 beta Homo sapiens 158-167 28367588-1 2017 BACKGROUND AND OBJECTIVES: Lithium chloride (LiCl) has been shown to improve the tightness of brain endothelial cell monolayers in vitro by inhibition of the GSK-3beta enzyme, activation of the Wnt/beta-catenin pathway and regulation of tight junction (TJ) protein expression. Lithium Chloride 45-49 catenin beta 1 Homo sapiens 198-210 28367588-6 2017 RESULTS: Our study showed that LiCl treatment for 6 days at a concentration of 10 mM induced the TJ protein claudin-3, the ABC transporter BCRP/ABCG2, the cytochrome P-450 CYP1A1 and the glutathione-S-transferase GSTM3, while the other selected markers were not significantly affected. Lithium Chloride 31-35 claudin 3 Homo sapiens 108-117 28367588-6 2017 RESULTS: Our study showed that LiCl treatment for 6 days at a concentration of 10 mM induced the TJ protein claudin-3, the ABC transporter BCRP/ABCG2, the cytochrome P-450 CYP1A1 and the glutathione-S-transferase GSTM3, while the other selected markers were not significantly affected. Lithium Chloride 31-35 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 139-143 28367588-6 2017 RESULTS: Our study showed that LiCl treatment for 6 days at a concentration of 10 mM induced the TJ protein claudin-3, the ABC transporter BCRP/ABCG2, the cytochrome P-450 CYP1A1 and the glutathione-S-transferase GSTM3, while the other selected markers were not significantly affected. Lithium Chloride 31-35 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 144-149 28367588-6 2017 RESULTS: Our study showed that LiCl treatment for 6 days at a concentration of 10 mM induced the TJ protein claudin-3, the ABC transporter BCRP/ABCG2, the cytochrome P-450 CYP1A1 and the glutathione-S-transferase GSTM3, while the other selected markers were not significantly affected. Lithium Chloride 31-35 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 155-178 28367588-6 2017 RESULTS: Our study showed that LiCl treatment for 6 days at a concentration of 10 mM induced the TJ protein claudin-3, the ABC transporter BCRP/ABCG2, the cytochrome P-450 CYP1A1 and the glutathione-S-transferase GSTM3, while the other selected markers were not significantly affected. Lithium Chloride 31-35 glutathione S-transferase kappa 1 Homo sapiens 187-212 28367588-6 2017 RESULTS: Our study showed that LiCl treatment for 6 days at a concentration of 10 mM induced the TJ protein claudin-3, the ABC transporter BCRP/ABCG2, the cytochrome P-450 CYP1A1 and the glutathione-S-transferase GSTM3, while the other selected markers were not significantly affected. Lithium Chloride 31-35 glutathione S-transferase mu 3 Homo sapiens 213-218 29039491-11 2017 The pathway activity can be modulated by LiCl at the GSK3beta-SUFU-GLI level, suggesting at least partial non-canonical activation. Lithium Chloride 41-45 glycogen synthase kinase 3 beta Homo sapiens 53-61 29039491-11 2017 The pathway activity can be modulated by LiCl at the GSK3beta-SUFU-GLI level, suggesting at least partial non-canonical activation. Lithium Chloride 41-45 SUFU negative regulator of hedgehog signaling Homo sapiens 62-66 29079596-8 2018 The decreased differentiation capacity of erythropoietin-pretreated mesenchymal stromal cells from patients with myelodysplasia could be restored by activating the Wnt pathway using lithium chloride or parathyroid hormone. Lithium Chloride 182-198 erythropoietin Homo sapiens 42-56 31966540-8 2017 But, that was reversed by the treatment with LiCl (lithium chloride) which could activate canonical Wnt/beta-catenin signaling pathway. Lithium Chloride 51-67 catenin beta 1 Homo sapiens 104-116 29039491-11 2017 The pathway activity can be modulated by LiCl at the GSK3beta-SUFU-GLI level, suggesting at least partial non-canonical activation. Lithium Chloride 41-45 GLI family zinc finger 1 Homo sapiens 67-70 28920943-11 2017 WNT/beta-catenin activation by lithium chloride inhibited TBX1 expression levels both in HEK293 and PAd-derived cells. Lithium Chloride 31-47 catenin beta 1 Homo sapiens 4-16 28920943-11 2017 WNT/beta-catenin activation by lithium chloride inhibited TBX1 expression levels both in HEK293 and PAd-derived cells. Lithium Chloride 31-47 T-box transcription factor 1 Homo sapiens 58-62 29156592-7 2017 Lithium chloride (LiCl, 1 mM), gabapentin (100 muM), valproate (100 muM), and carbamazepine (100 muM) increased TREK-1 currents by 31 +- 14%, 25 +- 11%, 28 +- 12%, and 72 +- 12%, respectively, whereas they had no effect on TREK-2 channel activity. Lithium Chloride 0-16 potassium channel, subfamily K, member 2 Mus musculus 112-118 29021340-3 2017 beta4-subunit-mediated inhibition of Wnt signaling is observed in the presence of LiCl, an inhibitor of glycogen synthase kinase (GSK3) that promotes beta-catenin translocation to the nucleus. Lithium Chloride 82-86 catenin beta 1 Homo sapiens 150-162 29039516-9 2017 Finally, LiCl (a beta-catenin stabilizer) induced apoptosis of H9c2 cells by upregulating the expression of beta-catenin, which was significantly neutralized by the treatment with baicalin. Lithium Chloride 9-13 catenin beta 1 Rattus norvegicus 17-29 29039516-9 2017 Finally, LiCl (a beta-catenin stabilizer) induced apoptosis of H9c2 cells by upregulating the expression of beta-catenin, which was significantly neutralized by the treatment with baicalin. Lithium Chloride 9-13 catenin beta 1 Rattus norvegicus 108-120 29156592-7 2017 Lithium chloride (LiCl, 1 mM), gabapentin (100 muM), valproate (100 muM), and carbamazepine (100 muM) increased TREK-1 currents by 31 +- 14%, 25 +- 11%, 28 +- 12%, and 72 +- 12%, respectively, whereas they had no effect on TREK-2 channel activity. Lithium Chloride 0-16 potassium channel, subfamily K, member 10 Mus musculus 223-229 29156592-7 2017 Lithium chloride (LiCl, 1 mM), gabapentin (100 muM), valproate (100 muM), and carbamazepine (100 muM) increased TREK-1 currents by 31 +- 14%, 25 +- 11%, 28 +- 12%, and 72 +- 12%, respectively, whereas they had no effect on TREK-2 channel activity. Lithium Chloride 18-22 potassium channel, subfamily K, member 2 Mus musculus 112-118 29156592-7 2017 Lithium chloride (LiCl, 1 mM), gabapentin (100 muM), valproate (100 muM), and carbamazepine (100 muM) increased TREK-1 currents by 31 +- 14%, 25 +- 11%, 28 +- 12%, and 72 +- 12%, respectively, whereas they had no effect on TREK-2 channel activity. Lithium Chloride 18-22 potassium channel, subfamily K, member 10 Mus musculus 223-229 29156592-8 2017 In addition, western blot analysis showed LiCl and carbamazepine slightly upregulated TREK-1 expression, but not TREK-2 in the HT-22 cells. Lithium Chloride 42-46 potassium channel, subfamily K, member 2 Mus musculus 86-92 29022339-4 2017 Moreover, resveratrol potently induced GSK-3beta Ser9 phosphorylation and reduced Na3VO4-induced p-S396-tau levels, which were markedly replicated by pharmacologic inhibition of GSK-3beta with LiCl. Lithium Chloride 193-197 glycogen synthase kinase 3 alpha Rattus norvegicus 178-187 29120400-5 2017 Also, OCCM30-fibrin expressed biomineralization-associated markers at higher levels than OCCM30-TCD, of which levels were further increased with LiCl, a Wnt signaling activator. Lithium Chloride 145-149 Wnt family member 3A Homo sapiens 153-156 29120400-7 2017 Activation of canonical Wnt signaling with LiCl treatment or with forced lymphoid enhancer factor 1 (LEF1)-expression increased the expression of plasminogen. Lithium Chloride 43-47 Wnt family member 3A Homo sapiens 24-27 28870805-4 2017 Mechanistically, our findings showed that inhibition of RAI3 in hASCs reduced the expression of beta-catenin, and lithium chloride which can activate the beta-catenin pathway abolished the effect of RAI3 knockdown on the adipogenesis. Lithium Chloride 114-130 catenin beta 1 Homo sapiens 154-166 28870805-4 2017 Mechanistically, our findings showed that inhibition of RAI3 in hASCs reduced the expression of beta-catenin, and lithium chloride which can activate the beta-catenin pathway abolished the effect of RAI3 knockdown on the adipogenesis. Lithium Chloride 114-130 G protein-coupled receptor class C group 5 member A Homo sapiens 199-203 29201236-11 2017 Lithium chloride, a wnt/beta-catenin signaling activator, was able to attenuate the effect of ARHI on HCT116 cell invasion and adhesion. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 24-36 28880013-8 2017 In addition, inhibition of GSK3beta by LiCl prevented osimertinib-induced PD-L1 degradation. Lithium Chloride 39-43 glycogen synthase kinase 3 beta Homo sapiens 27-35 28880013-8 2017 In addition, inhibition of GSK3beta by LiCl prevented osimertinib-induced PD-L1 degradation. Lithium Chloride 39-43 CD274 molecule Homo sapiens 74-79 29201236-11 2017 Lithium chloride, a wnt/beta-catenin signaling activator, was able to attenuate the effect of ARHI on HCT116 cell invasion and adhesion. Lithium Chloride 0-16 DIRAS family GTPase 3 Homo sapiens 94-98 28593525-0 2017 Lithium Chloride Facilitates Autophagy Following Spinal Cord Injury via ERK-dependent Pathway. Lithium Chloride 0-16 mitogen-activated protein kinase 1 Homo sapiens 72-75 28650075-5 2017 Molecular analyses of developing and adult incisors revealed that epithelial deletion of Isl1 affected multiple, major pathways: Bmp (bone morphogenetic protein), Hh (hedgehog), Fgf (fibroblast growth factor), and Notch signaling were upregulated and associated with liCL-generated ectopic enamel; on the labial side, upregulation of Bmp and Fgf signaling, and downregulation of Shh were associated with premature enamel formation. Lithium Chloride 267-271 ISL1 transcription factor, LIM/homeodomain Mus musculus 89-93 29030155-10 2017 LiCl, an inhibitor of beta-catenin degradation, decreased ERalpha expression but increased ERalpha transcription activity. Lithium Chloride 0-4 catenin beta 1 Homo sapiens 22-34 29030155-10 2017 LiCl, an inhibitor of beta-catenin degradation, decreased ERalpha expression but increased ERalpha transcription activity. Lithium Chloride 0-4 estrogen receptor 1 Homo sapiens 58-65 29030155-10 2017 LiCl, an inhibitor of beta-catenin degradation, decreased ERalpha expression but increased ERalpha transcription activity. Lithium Chloride 0-4 estrogen receptor 1 Homo sapiens 91-98 28593525-6 2017 However, lithium chloride enhanced the level of LC3-II while abrogated the abundance of p62. Lithium Chloride 9-25 nucleoporin 62 Homo sapiens 88-91 28901456-6 2017 ATO also attenuated upregulation of beta-catenin after LiCl stimulation and provided synergistic effect with 5-azacytidine (5-azaC) on the DNMT-1 inhibition. Lithium Chloride 55-59 catenin beta 1 Homo sapiens 36-48 28267420-6 2017 Of specific interest here was that LiCl, a Wnt/beta-catenin signaling specific activator, attenuated the FTO-induced upregulation of PPARgamma and downregulation of beta-catenin. Lithium Chloride 35-39 catenin beta 1 Homo sapiens 47-59 29070854-5 2017 Moreover, in a rat model of lithium chloride-pilocarpine-induced epilepsy, norbin expression began to decrease at 6 h after the onset of status epilepticus and remained at a low level until 60 days. Lithium Chloride 28-44 neurochondrin Rattus norvegicus 75-81 29070854-8 2017 Finally, norbin over-expression facilitated by injections of adeno-associated viral vector into the rat hippocampus increased latency and survival in the lithium chloride-pilocarpine model. Lithium Chloride 154-170 neurochondrin Rattus norvegicus 9-15 29049420-8 2017 Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells. Lithium Chloride 22-26 interleukin 1 beta Homo sapiens 51-59 29049420-8 2017 Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells. Lithium Chloride 22-26 tumor necrosis factor Homo sapiens 61-70 29049420-8 2017 Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells. Lithium Chloride 22-26 interleukin 6 Homo sapiens 72-76 29049420-8 2017 Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells. Lithium Chloride 22-26 nitric oxide synthase 2 Homo sapiens 78-82 29049420-8 2017 Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells. Lithium Chloride 22-26 mitochondrially encoded cytochrome c oxidase II Homo sapiens 84-88 29049420-8 2017 Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells. Lithium Chloride 22-26 C-C motif chemokine ligand 2 Homo sapiens 93-98 29049420-8 2017 Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells. Lithium Chloride 151-155 mitochondrially encoded cytochrome c oxidase II Homo sapiens 84-88 29049420-8 2017 Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells. Lithium Chloride 151-155 interleukin 10 Homo sapiens 109-114 29049420-10 2017 Additionally, NF-kappaB/p65 immunofluorescence was attenuated by DAPT and LiCl; as opposed to this, IkappaBalpha protein expression was increased. Lithium Chloride 74-78 RELA proto-oncogene, NF-kB subunit Homo sapiens 24-27 28267420-6 2017 Of specific interest here was that LiCl, a Wnt/beta-catenin signaling specific activator, attenuated the FTO-induced upregulation of PPARgamma and downregulation of beta-catenin. Lithium Chloride 35-39 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 105-108 28267420-6 2017 Of specific interest here was that LiCl, a Wnt/beta-catenin signaling specific activator, attenuated the FTO-induced upregulation of PPARgamma and downregulation of beta-catenin. Lithium Chloride 35-39 peroxisome proliferator activated receptor gamma Homo sapiens 133-142 28267420-6 2017 Of specific interest here was that LiCl, a Wnt/beta-catenin signaling specific activator, attenuated the FTO-induced upregulation of PPARgamma and downregulation of beta-catenin. Lithium Chloride 35-39 catenin beta 1 Homo sapiens 165-177 28849076-9 2017 Moreover, inhibition of the EMT and the Wnt/beta-catenin signaling pathway induced by GNL3 knockdown was partially reversed by lithium chloride (LiCl). Lithium Chloride 127-143 catenin beta 1 Homo sapiens 44-56 27840100-14 2017 Blockade of GSK-3beta expression by siRNA and inhibition of GSK-3beta activity by lithium chloride significantly reduced tanshinone IIA-induced AQP1 and AQP3 expression (All P<0.05). Lithium Chloride 82-98 glycogen synthase kinase 3 beta Homo sapiens 60-69 27840100-14 2017 Blockade of GSK-3beta expression by siRNA and inhibition of GSK-3beta activity by lithium chloride significantly reduced tanshinone IIA-induced AQP1 and AQP3 expression (All P<0.05). Lithium Chloride 82-98 aquaporin 1 (Colton blood group) Homo sapiens 144-148 27840100-14 2017 Blockade of GSK-3beta expression by siRNA and inhibition of GSK-3beta activity by lithium chloride significantly reduced tanshinone IIA-induced AQP1 and AQP3 expression (All P<0.05). Lithium Chloride 82-98 aquaporin 3 (Gill blood group) Homo sapiens 153-157 28929374-7 2017 Lithium chloride (LiCl), which increases p-GSK-3beta level and active-beta-catenin level, reversed retinal degeneration induced by MNU treatment. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Rattus norvegicus 43-52 28929374-7 2017 Lithium chloride (LiCl), which increases p-GSK-3beta level and active-beta-catenin level, reversed retinal degeneration induced by MNU treatment. Lithium Chloride 0-16 catenin beta 1 Rattus norvegicus 70-82 28929374-7 2017 Lithium chloride (LiCl), which increases p-GSK-3beta level and active-beta-catenin level, reversed retinal degeneration induced by MNU treatment. Lithium Chloride 18-22 glycogen synthase kinase 3 beta Rattus norvegicus 43-52 28929374-7 2017 Lithium chloride (LiCl), which increases p-GSK-3beta level and active-beta-catenin level, reversed retinal degeneration induced by MNU treatment. Lithium Chloride 18-22 catenin beta 1 Rattus norvegicus 70-82 28929374-8 2017 These results suggest that GSK-3beta activation is closely related to photoreceptor cell loss and that the application of the GSK-3beta inhibitor LiCl could activate Wnt/beta-catenin signaling pathway and reduce photoreceptor cell loss induced by MNU. Lithium Chloride 146-150 glycogen synthase kinase 3 beta Rattus norvegicus 27-36 28929374-8 2017 These results suggest that GSK-3beta activation is closely related to photoreceptor cell loss and that the application of the GSK-3beta inhibitor LiCl could activate Wnt/beta-catenin signaling pathway and reduce photoreceptor cell loss induced by MNU. Lithium Chloride 146-150 glycogen synthase kinase 3 beta Rattus norvegicus 126-135 28929374-8 2017 These results suggest that GSK-3beta activation is closely related to photoreceptor cell loss and that the application of the GSK-3beta inhibitor LiCl could activate Wnt/beta-catenin signaling pathway and reduce photoreceptor cell loss induced by MNU. Lithium Chloride 146-150 Wnt family member 2 Rattus norvegicus 166-169 28929374-8 2017 These results suggest that GSK-3beta activation is closely related to photoreceptor cell loss and that the application of the GSK-3beta inhibitor LiCl could activate Wnt/beta-catenin signaling pathway and reduce photoreceptor cell loss induced by MNU. Lithium Chloride 146-150 catenin beta 1 Rattus norvegicus 170-182 29171428-11 2017 Ischemic post-conditioning with glycogen synthase kinase 3 beta inhibitor lithium chloride can effectively reverse these changes. Lithium Chloride 74-90 glycogen synthase kinase 3 beta Rattus norvegicus 32-63 28943961-7 2017 Moreover, the stimulation effects of lithium chloride, a GSK3beta inhibitor, on the accumulation of beta-catenin were notably suppressed by ARHGAP10 overexpression. Lithium Chloride 37-53 glycogen synthase kinase 3 beta Homo sapiens 57-65 28849076-9 2017 Moreover, inhibition of the EMT and the Wnt/beta-catenin signaling pathway induced by GNL3 knockdown was partially reversed by lithium chloride (LiCl). Lithium Chloride 127-143 G protein nucleolar 3 Homo sapiens 86-90 28943961-7 2017 Moreover, the stimulation effects of lithium chloride, a GSK3beta inhibitor, on the accumulation of beta-catenin were notably suppressed by ARHGAP10 overexpression. Lithium Chloride 37-53 catenin beta 1 Homo sapiens 100-112 28943961-7 2017 Moreover, the stimulation effects of lithium chloride, a GSK3beta inhibitor, on the accumulation of beta-catenin were notably suppressed by ARHGAP10 overexpression. Lithium Chloride 37-53 Rho GTPase activating protein 10 Homo sapiens 140-148 29085489-4 2017 Following incubation of CaSki cells with 0.05 and 0.1 mol/l lithium chloride, Twist and beta-catenin were markedly upregulated at the mRNA and protein levels, respectively, compared with the untreated group, as measured by reverse transcription-polymerase chain reaction and western blotting. Lithium Chloride 60-76 catenin beta 1 Homo sapiens 88-100 28849076-9 2017 Moreover, inhibition of the EMT and the Wnt/beta-catenin signaling pathway induced by GNL3 knockdown was partially reversed by lithium chloride (LiCl). Lithium Chloride 145-149 catenin beta 1 Homo sapiens 44-56 28849076-9 2017 Moreover, inhibition of the EMT and the Wnt/beta-catenin signaling pathway induced by GNL3 knockdown was partially reversed by lithium chloride (LiCl). Lithium Chloride 145-149 G protein nucleolar 3 Homo sapiens 86-90 28926590-9 2017 Fluoxetine suppressed LiCl-induced beta-catenin accumulation in human OA chondrocytes. Lithium Chloride 22-26 catenin beta 1 Homo sapiens 35-47 28929469-10 2017 LiCl treatment rescued cilia loss in P5 cells, partially restoring hedgehog signalling, so that GLI1 expression was significantly increased by Indian hedgehog. Lithium Chloride 0-4 GLI family zinc finger 1 Homo sapiens 96-100 28926590-7 2017 Fluoxetine suppressed a LiCl-induced increase of total beta-catenin and a LiCl-induced decrease of phosphorylated beta-catenin in a dose-dependent manner. Lithium Chloride 24-28 catenin beta 1 Homo sapiens 55-67 28926590-7 2017 Fluoxetine suppressed a LiCl-induced increase of total beta-catenin and a LiCl-induced decrease of phosphorylated beta-catenin in a dose-dependent manner. Lithium Chloride 24-28 catenin beta 1 Homo sapiens 114-126 28911173-0 2017 Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3beta/beta-Catenin Signaling Pathway. Lithium Chloride 0-16 mitochondrially encoded cytochrome c oxidase II Homo sapiens 27-32 28926590-7 2017 Fluoxetine suppressed a LiCl-induced increase of total beta-catenin and a LiCl-induced decrease of phosphorylated beta-catenin in a dose-dependent manner. Lithium Chloride 74-78 catenin beta 1 Homo sapiens 114-126 28734031-12 2017 Interestingly, LY294002, an inhibitor of PI3K/Akt signaling, aggravated, whereas LiCl, an activator of Wnt/beta-catenin signaling, abolished the reduction in DEC1 by MPP+ . Lithium Chloride 81-85 catenin (cadherin associated protein), beta 1 Mus musculus 107-119 28734031-12 2017 Interestingly, LY294002, an inhibitor of PI3K/Akt signaling, aggravated, whereas LiCl, an activator of Wnt/beta-catenin signaling, abolished the reduction in DEC1 by MPP+ . Lithium Chloride 81-85 basic helix-loop-helix family, member e40 Mus musculus 158-162 28911173-9 2017 These results indicate that LiCl upregulates the expression of COX-2 and the subsequent production of PGE2 through the canonical GSK-3beta/beta-catenin signaling pathway in hGL cells. Lithium Chloride 28-32 mitochondrially encoded cytochrome c oxidase II Homo sapiens 63-68 29163781-6 2017 SYNJ2BP increased the levels of phosphorylation for AKT and GSK3beta, which could be inhibited by the PI3K inhibitor, LY294002, and the GSK3beta inhibitor, LiCl, and regulated the accumulation of SNAI1 in the nucleus and the expression of the SNAI1 target gene, E-cadherin (EMT marker). Lithium Chloride 156-160 synaptojanin 2 binding protein Mus musculus 0-7 29163781-6 2017 SYNJ2BP increased the levels of phosphorylation for AKT and GSK3beta, which could be inhibited by the PI3K inhibitor, LY294002, and the GSK3beta inhibitor, LiCl, and regulated the accumulation of SNAI1 in the nucleus and the expression of the SNAI1 target gene, E-cadherin (EMT marker). Lithium Chloride 156-160 thymoma viral proto-oncogene 1 Mus musculus 52-55 29163781-6 2017 SYNJ2BP increased the levels of phosphorylation for AKT and GSK3beta, which could be inhibited by the PI3K inhibitor, LY294002, and the GSK3beta inhibitor, LiCl, and regulated the accumulation of SNAI1 in the nucleus and the expression of the SNAI1 target gene, E-cadherin (EMT marker). Lithium Chloride 156-160 glycogen synthase kinase 3 beta Mus musculus 60-68 29163781-6 2017 SYNJ2BP increased the levels of phosphorylation for AKT and GSK3beta, which could be inhibited by the PI3K inhibitor, LY294002, and the GSK3beta inhibitor, LiCl, and regulated the accumulation of SNAI1 in the nucleus and the expression of the SNAI1 target gene, E-cadherin (EMT marker). Lithium Chloride 156-160 glycogen synthase kinase 3 beta Mus musculus 136-144 28821663-7 2017 Here, we show in mice that food deprivation or optogenetic activation of AgRP neurons induces feeding to overcome the appetite suppressing effects of amylin, CCK, and LiCl, but not LPS. Lithium Chloride 167-171 agouti related neuropeptide Mus musculus 73-77 28911173-0 2017 Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3beta/beta-Catenin Signaling Pathway. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 123-135 28911173-3 2017 Whether LiCl affects ovulation by regulating COX2 expression and PGE2 production in the human ovary is still largely unknown. Lithium Chloride 8-12 mitochondrially encoded cytochrome c oxidase II Homo sapiens 45-49 28911173-4 2017 The aim of this study was to investigate the effect of LiCl on the expression of COX-2 and production of PGE2 in human granulosa-lutein (hGL) cells, as well as the mechanisms underlying this effect. Lithium Chloride 55-59 mitochondrially encoded cytochrome c oxidase II Homo sapiens 81-86 28911173-4 2017 The aim of this study was to investigate the effect of LiCl on the expression of COX-2 and production of PGE2 in human granulosa-lutein (hGL) cells, as well as the mechanisms underlying this effect. Lithium Chloride 55-59 LLGL scribble cell polarity complex component 2 Homo sapiens 137-140 28911173-6 2017 Using dual inhibition approaches, our results show that LiCl initiates the hGL cellular action by inhibiting the activity of glycogen synthase kinase-3beta [GSK-3beta (phosphorylation of GSK-3beta)] and activation of extracellular signal-regulated kinase 1/2 (ERK1/2), but not by affecting protein kinase B or cAMP response element binding protein signaling. Lithium Chloride 56-60 LLGL scribble cell polarity complex component 2 Homo sapiens 75-78 28911173-6 2017 Using dual inhibition approaches, our results show that LiCl initiates the hGL cellular action by inhibiting the activity of glycogen synthase kinase-3beta [GSK-3beta (phosphorylation of GSK-3beta)] and activation of extracellular signal-regulated kinase 1/2 (ERK1/2), but not by affecting protein kinase B or cAMP response element binding protein signaling. Lithium Chloride 56-60 glycogen synthase kinase 3 beta Homo sapiens 125-155 28605600-7 2017 Furthermore, in utero treatment with either lithium chloride, an agonist of canonical Wnt signaling, or the DKK inhibitor IIIC3a rescued mandibular molar tooth morphogenesis in Inhba-/- embryos. Lithium Chloride 44-60 inhibin beta-A Mus musculus 177-182 28911173-6 2017 Using dual inhibition approaches, our results show that LiCl initiates the hGL cellular action by inhibiting the activity of glycogen synthase kinase-3beta [GSK-3beta (phosphorylation of GSK-3beta)] and activation of extracellular signal-regulated kinase 1/2 (ERK1/2), but not by affecting protein kinase B or cAMP response element binding protein signaling. Lithium Chloride 56-60 glycogen synthase kinase 3 beta Homo sapiens 157-166 28911173-6 2017 Using dual inhibition approaches, our results show that LiCl initiates the hGL cellular action by inhibiting the activity of glycogen synthase kinase-3beta [GSK-3beta (phosphorylation of GSK-3beta)] and activation of extracellular signal-regulated kinase 1/2 (ERK1/2), but not by affecting protein kinase B or cAMP response element binding protein signaling. Lithium Chloride 56-60 glycogen synthase kinase 3 beta Homo sapiens 187-196 28911173-6 2017 Using dual inhibition approaches, our results show that LiCl initiates the hGL cellular action by inhibiting the activity of glycogen synthase kinase-3beta [GSK-3beta (phosphorylation of GSK-3beta)] and activation of extracellular signal-regulated kinase 1/2 (ERK1/2), but not by affecting protein kinase B or cAMP response element binding protein signaling. Lithium Chloride 56-60 mitogen-activated protein kinase 1 Homo sapiens 217-258 28911173-6 2017 Using dual inhibition approaches, our results show that LiCl initiates the hGL cellular action by inhibiting the activity of glycogen synthase kinase-3beta [GSK-3beta (phosphorylation of GSK-3beta)] and activation of extracellular signal-regulated kinase 1/2 (ERK1/2), but not by affecting protein kinase B or cAMP response element binding protein signaling. Lithium Chloride 56-60 mitogen-activated protein kinase 3 Homo sapiens 260-266 28911173-8 2017 Furthermore, knockdown of either beta-catenin or GSK-3beta reversed the LiCl-induced upregulation of COX-2 expression. Lithium Chloride 72-76 catenin beta 1 Homo sapiens 33-45 28911173-8 2017 Furthermore, knockdown of either beta-catenin or GSK-3beta reversed the LiCl-induced upregulation of COX-2 expression. Lithium Chloride 72-76 glycogen synthase kinase 3 beta Homo sapiens 49-58 28911173-8 2017 Furthermore, knockdown of either beta-catenin or GSK-3beta reversed the LiCl-induced upregulation of COX-2 expression. Lithium Chloride 72-76 mitochondrially encoded cytochrome c oxidase II Homo sapiens 101-106 28911173-9 2017 These results indicate that LiCl upregulates the expression of COX-2 and the subsequent production of PGE2 through the canonical GSK-3beta/beta-catenin signaling pathway in hGL cells. Lithium Chloride 28-32 glycogen synthase kinase 3 beta Homo sapiens 129-138 28911173-9 2017 These results indicate that LiCl upregulates the expression of COX-2 and the subsequent production of PGE2 through the canonical GSK-3beta/beta-catenin signaling pathway in hGL cells. Lithium Chloride 28-32 catenin beta 1 Homo sapiens 139-151 28911173-9 2017 These results indicate that LiCl upregulates the expression of COX-2 and the subsequent production of PGE2 through the canonical GSK-3beta/beta-catenin signaling pathway in hGL cells. Lithium Chloride 28-32 LLGL scribble cell polarity complex component 2 Homo sapiens 173-176 27624386-7 2017 Moreover, lithium chloride (LiCl), a GSK3beta inhibitor, increased neuronal differentiation by inhibiting the proliferation of NPCs. Lithium Chloride 10-26 glycogen synthase kinase 3 beta Rattus norvegicus 37-45 28093288-0 2017 Assessing the Impact of Lithium Chloride on the Expression of P-Glycoprotein at the Blood-Brain Barrier. Lithium Chloride 24-40 ATP binding cassette subfamily B member 1 Homo sapiens 62-76 28093288-3 2017 Although the mechanisms underlying this effect are not fully understood, evidence suggests that lithium chloride (LiCl) increases P-gp expression in vitro, albeit at concentrations substantially outside the therapeutic window. Lithium Chloride 96-112 ATP binding cassette subfamily B member 1 Homo sapiens 130-134 28093288-3 2017 Although the mechanisms underlying this effect are not fully understood, evidence suggests that lithium chloride (LiCl) increases P-gp expression in vitro, albeit at concentrations substantially outside the therapeutic window. Lithium Chloride 114-118 ATP binding cassette subfamily B member 1 Homo sapiens 130-134 28093288-4 2017 Therefore, we investigated the effects of pharmacologically-relevant concentrations of LiCl on P-gp expression using in vitro and in vivo approaches. Lithium Chloride 87-91 ATP binding cassette subfamily B member 1 Homo sapiens 95-99 27624386-7 2017 Moreover, lithium chloride (LiCl), a GSK3beta inhibitor, increased neuronal differentiation by inhibiting the proliferation of NPCs. Lithium Chloride 28-32 glycogen synthase kinase 3 beta Rattus norvegicus 37-45 28347817-4 2017 Meanwhile, activation Wnt3a/beta-catenin signal with exogenous Wnt3alpha protein (100 ng/ml) or Lithium Chloride (LiCl, 4 mM) decreased significantly apoptosis of BMECs induced by OGD with increasing expression of Bcl-2 in the whole cell and beta-catenin in the nucleus. Lithium Chloride 96-112 Wnt family member 3A Homo sapiens 22-27 28511952-3 2017 We determined that LiCl -attenuated LPS-induced activated toll-like receptor 4 (TLR4) signalling and significantly reduced the nuclear factor-kB (NF-KB) translation factor and various other inflammatory mediators such as interleukin-1 beta (IL-1beta) and tumour necrosis factor alpha (TNF-alpha). Lithium Chloride 19-23 toll-like receptor 4 Rattus norvegicus 58-78 28511952-3 2017 We determined that LiCl -attenuated LPS-induced activated toll-like receptor 4 (TLR4) signalling and significantly reduced the nuclear factor-kB (NF-KB) translation factor and various other inflammatory mediators such as interleukin-1 beta (IL-1beta) and tumour necrosis factor alpha (TNF-alpha). Lithium Chloride 19-23 toll-like receptor 4 Rattus norvegicus 80-84 28511952-3 2017 We determined that LiCl -attenuated LPS-induced activated toll-like receptor 4 (TLR4) signalling and significantly reduced the nuclear factor-kB (NF-KB) translation factor and various other inflammatory mediators such as interleukin-1 beta (IL-1beta) and tumour necrosis factor alpha (TNF-alpha). Lithium Chloride 19-23 interleukin 1 beta Rattus norvegicus 221-239 28511952-3 2017 We determined that LiCl -attenuated LPS-induced activated toll-like receptor 4 (TLR4) signalling and significantly reduced the nuclear factor-kB (NF-KB) translation factor and various other inflammatory mediators such as interleukin-1 beta (IL-1beta) and tumour necrosis factor alpha (TNF-alpha). Lithium Chloride 19-23 interleukin 1 beta Rattus norvegicus 241-249 28511952-3 2017 We determined that LiCl -attenuated LPS-induced activated toll-like receptor 4 (TLR4) signalling and significantly reduced the nuclear factor-kB (NF-KB) translation factor and various other inflammatory mediators such as interleukin-1 beta (IL-1beta) and tumour necrosis factor alpha (TNF-alpha). Lithium Chloride 19-23 tumor necrosis factor Rattus norvegicus 285-294 28511952-5 2017 Furthermore, we also observed that LiCl treatment significantly ameliorated the increase expression level of apoptotic neurodegeneration protein markers Bax/Bcl2, activated caspase-3 and poly (ADP-ribose) polymerase-1 (PARP-1) in the cortex and hippocampus regions of the LPS-treated adult rat brain. Lithium Chloride 35-39 BCL2 associated X, apoptosis regulator Rattus norvegicus 153-156 28511952-5 2017 Furthermore, we also observed that LiCl treatment significantly ameliorated the increase expression level of apoptotic neurodegeneration protein markers Bax/Bcl2, activated caspase-3 and poly (ADP-ribose) polymerase-1 (PARP-1) in the cortex and hippocampus regions of the LPS-treated adult rat brain. Lithium Chloride 35-39 BCL2, apoptosis regulator Rattus norvegicus 157-161 28511952-5 2017 Furthermore, we also observed that LiCl treatment significantly ameliorated the increase expression level of apoptotic neurodegeneration protein markers Bax/Bcl2, activated caspase-3 and poly (ADP-ribose) polymerase-1 (PARP-1) in the cortex and hippocampus regions of the LPS-treated adult rat brain. Lithium Chloride 35-39 caspase 3 Rattus norvegicus 173-217 28511952-5 2017 Furthermore, we also observed that LiCl treatment significantly ameliorated the increase expression level of apoptotic neurodegeneration protein markers Bax/Bcl2, activated caspase-3 and poly (ADP-ribose) polymerase-1 (PARP-1) in the cortex and hippocampus regions of the LPS-treated adult rat brain. Lithium Chloride 35-39 poly (ADP-ribose) polymerase 1 Rattus norvegicus 219-225 28347817-4 2017 Meanwhile, activation Wnt3a/beta-catenin signal with exogenous Wnt3alpha protein (100 ng/ml) or Lithium Chloride (LiCl, 4 mM) decreased significantly apoptosis of BMECs induced by OGD with increasing expression of Bcl-2 in the whole cell and beta-catenin in the nucleus. Lithium Chloride 96-112 catenin beta 1 Homo sapiens 28-40 28347817-4 2017 Meanwhile, activation Wnt3a/beta-catenin signal with exogenous Wnt3alpha protein (100 ng/ml) or Lithium Chloride (LiCl, 4 mM) decreased significantly apoptosis of BMECs induced by OGD with increasing expression of Bcl-2 in the whole cell and beta-catenin in the nucleus. Lithium Chloride 96-112 BCL2 apoptosis regulator Homo sapiens 214-219 28347817-4 2017 Meanwhile, activation Wnt3a/beta-catenin signal with exogenous Wnt3alpha protein (100 ng/ml) or Lithium Chloride (LiCl, 4 mM) decreased significantly apoptosis of BMECs induced by OGD with increasing expression of Bcl-2 in the whole cell and beta-catenin in the nucleus. Lithium Chloride 96-112 catenin beta 1 Homo sapiens 242-254 28347817-4 2017 Meanwhile, activation Wnt3a/beta-catenin signal with exogenous Wnt3alpha protein (100 ng/ml) or Lithium Chloride (LiCl, 4 mM) decreased significantly apoptosis of BMECs induced by OGD with increasing expression of Bcl-2 in the whole cell and beta-catenin in the nucleus. Lithium Chloride 114-118 Wnt family member 3A Homo sapiens 22-27 28347817-4 2017 Meanwhile, activation Wnt3a/beta-catenin signal with exogenous Wnt3alpha protein (100 ng/ml) or Lithium Chloride (LiCl, 4 mM) decreased significantly apoptosis of BMECs induced by OGD with increasing expression of Bcl-2 in the whole cell and beta-catenin in the nucleus. Lithium Chloride 114-118 catenin beta 1 Homo sapiens 28-40 28347817-4 2017 Meanwhile, activation Wnt3a/beta-catenin signal with exogenous Wnt3alpha protein (100 ng/ml) or Lithium Chloride (LiCl, 4 mM) decreased significantly apoptosis of BMECs induced by OGD with increasing expression of Bcl-2 in the whole cell and beta-catenin in the nucleus. Lithium Chloride 114-118 BCL2 apoptosis regulator Homo sapiens 214-219 28347817-4 2017 Meanwhile, activation Wnt3a/beta-catenin signal with exogenous Wnt3alpha protein (100 ng/ml) or Lithium Chloride (LiCl, 4 mM) decreased significantly apoptosis of BMECs induced by OGD with increasing expression of Bcl-2 in the whole cell and beta-catenin in the nucleus. Lithium Chloride 114-118 catenin beta 1 Homo sapiens 242-254 28790387-11 2017 Inhibition of GSK3beta by LiCl reduces its level, but the inhibition of ERK by PD98059 increases it. Lithium Chloride 26-30 glycogen synthase kinase 3 beta Mus musculus 14-22 28848439-3 2017 In this study, a lithium chloride-pilocarpine-induced status epilepticus model was established and treated with intracerebroventricular injection of antagomirs targeting miR-134 (Ant-134). Lithium Chloride 17-33 microRNA 134 Rattus norvegicus 170-177 28624572-6 2017 Furthermore, downregulating beta-catenin expression in the NAc in shocked rats using sulindac (0.0178, 0.178mg/side) impaired extinction whereas upregulating the Wnt/beta-catenin pathway using LiCl (2microg/side) facilitated extinction. Lithium Chloride 193-197 catenin beta 1 Rattus norvegicus 28-40 29137395-7 2017 In vitro, LiCl inhibited osteoclastogenesis and osteoclastic bone resorption by inhibiting the RANKL-induced NF-kappaB signaling pathway. Lithium Chloride 10-14 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 95-100 29137395-8 2017 LiCl"s activation of the canonical Wnt/beta-catenin signaling pathway was not associated with LiCl"s inhibition of osteoclastogenesis. Lithium Chloride 0-4 catenin (cadherin associated protein), beta 1 Mus musculus 39-51 28807209-9 2017 After reperfusion, rats were observed for 30 min, 6, 24, and 48 h. RESULTS: Lithium chloride appeared to protect hepatocytes from IRI via its ability to induce autophagy by modulation of both GSK3b and ERK1/2 pathways. Lithium Chloride 76-92 glycogen synthase kinase 3 beta Rattus norvegicus 192-197 28606794-7 2017 Finally, lithium chloride, a GSK3 inhibitor, also attenuated the TGF-beta1-induced increase in alpha-SMA, COL1, and FN expression. Lithium Chloride 9-25 transforming growth factor beta 1 Homo sapiens 65-74 28606794-7 2017 Finally, lithium chloride, a GSK3 inhibitor, also attenuated the TGF-beta1-induced increase in alpha-SMA, COL1, and FN expression. Lithium Chloride 9-25 fibronectin 1 Homo sapiens 116-118 28807209-9 2017 After reperfusion, rats were observed for 30 min, 6, 24, and 48 h. RESULTS: Lithium chloride appeared to protect hepatocytes from IRI via its ability to induce autophagy by modulation of both GSK3b and ERK1/2 pathways. Lithium Chloride 76-92 mitogen activated protein kinase 3 Rattus norvegicus 202-208 28670780-6 2017 RESULTS: The density of trabecular bone, the quantity of osteoblasts and the expression of osteogenic markers, Runx2 and Osterix, were significantly higher in the LiCl group than in the control group during the orthodontic retention period. Lithium Chloride 163-167 RUNX family transcription factor 2 Rattus norvegicus 111-116 28397069-0 2017 LiCl Treatment Induces Programmed Cell Death of Schwannoma Cells through AKT- and MTOR-Mediated Necroptosis. Lithium Chloride 0-4 AKT serine/threonine kinase 1 Homo sapiens 73-76 28397069-0 2017 LiCl Treatment Induces Programmed Cell Death of Schwannoma Cells through AKT- and MTOR-Mediated Necroptosis. Lithium Chloride 0-4 mechanistic target of rapamycin kinase Homo sapiens 82-86 28397069-4 2017 In this study, we found that lithium chloride (LiCl) significantly inhibits the proliferation of both RT4 cells and human NF2-associated primary schwannoma cells by inhibiting the expression of apoptosis-related proteins. Lithium Chloride 29-45 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 122-125 28397069-4 2017 In this study, we found that lithium chloride (LiCl) significantly inhibits the proliferation of both RT4 cells and human NF2-associated primary schwannoma cells by inhibiting the expression of apoptosis-related proteins. Lithium Chloride 47-51 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 122-125 28397069-5 2017 LiCl-induced cell death exhibits ultrastructural features of necrosis and is reversed by the RIPK1-specific inhibitor necrostatin-1 in a dose-dependent manner, indicating that LiCl induces the necroptosis type of cell death. Lithium Chloride 0-4 receptor interacting serine/threonine kinase 1 Homo sapiens 93-98 28397069-5 2017 LiCl-induced cell death exhibits ultrastructural features of necrosis and is reversed by the RIPK1-specific inhibitor necrostatin-1 in a dose-dependent manner, indicating that LiCl induces the necroptosis type of cell death. Lithium Chloride 176-180 receptor interacting serine/threonine kinase 1 Homo sapiens 93-98 28397069-6 2017 Moreover, LiCl treatment induces ROS generation and activates the AKT/mTOR pathway, which is reversed by necrostatin-1 treatment. Lithium Chloride 10-14 AKT serine/threonine kinase 1 Homo sapiens 66-69 28397069-6 2017 Moreover, LiCl treatment induces ROS generation and activates the AKT/mTOR pathway, which is reversed by necrostatin-1 treatment. Lithium Chloride 10-14 mechanistic target of rapamycin kinase Homo sapiens 70-74 28397069-7 2017 Based on our results, LiCl treatment may induce the programmed cell death of schwannoma cells through AKT- and mTOR-mediated necroptosis, potentially representing a new mechanism by which LiCl induces tumor cell death. Lithium Chloride 22-26 AKT serine/threonine kinase 1 Homo sapiens 102-105 28397069-7 2017 Based on our results, LiCl treatment may induce the programmed cell death of schwannoma cells through AKT- and mTOR-mediated necroptosis, potentially representing a new mechanism by which LiCl induces tumor cell death. Lithium Chloride 22-26 mechanistic target of rapamycin kinase Homo sapiens 111-115 28397069-7 2017 Based on our results, LiCl treatment may induce the programmed cell death of schwannoma cells through AKT- and mTOR-mediated necroptosis, potentially representing a new mechanism by which LiCl induces tumor cell death. Lithium Chloride 188-192 AKT serine/threonine kinase 1 Homo sapiens 102-105 28397069-7 2017 Based on our results, LiCl treatment may induce the programmed cell death of schwannoma cells through AKT- and mTOR-mediated necroptosis, potentially representing a new mechanism by which LiCl induces tumor cell death. Lithium Chloride 188-192 mechanistic target of rapamycin kinase Homo sapiens 111-115 28670780-6 2017 RESULTS: The density of trabecular bone, the quantity of osteoblasts and the expression of osteogenic markers, Runx2 and Osterix, were significantly higher in the LiCl group than in the control group during the orthodontic retention period. Lithium Chloride 163-167 Sp7 transcription factor Rattus norvegicus 121-128 28903410-7 2017 Additionally, rescue assays revealed that the activation of Wnt signalling by LiCl treatment impaired the inhibitory effect of RASSF6 on the proliferation and metastasis of colorectal cancer cells, which implies that RASSF6 suppresses the tumorigenicity of colorectal cancer cells at least in part through inhibiting Wnt signalling pathway. Lithium Chloride 78-82 Ras association domain family member 6 Homo sapiens 127-133 28903410-7 2017 Additionally, rescue assays revealed that the activation of Wnt signalling by LiCl treatment impaired the inhibitory effect of RASSF6 on the proliferation and metastasis of colorectal cancer cells, which implies that RASSF6 suppresses the tumorigenicity of colorectal cancer cells at least in part through inhibiting Wnt signalling pathway. Lithium Chloride 78-82 Ras association domain family member 6 Homo sapiens 217-223 26996066-6 2017 Inactivation of GSK-3beta by LiCl (lithium chloride) treatment notably increased MMP-2 activity, vascular endothelial growth factor expression and EMT of MCF-7 cells. Lithium Chloride 29-33 glycogen synthase kinase 3 beta Homo sapiens 16-25 26996066-6 2017 Inactivation of GSK-3beta by LiCl (lithium chloride) treatment notably increased MMP-2 activity, vascular endothelial growth factor expression and EMT of MCF-7 cells. Lithium Chloride 29-33 matrix metallopeptidase 2 Homo sapiens 81-86 26996066-6 2017 Inactivation of GSK-3beta by LiCl (lithium chloride) treatment notably increased MMP-2 activity, vascular endothelial growth factor expression and EMT of MCF-7 cells. Lithium Chloride 29-33 vascular endothelial growth factor A Homo sapiens 97-131 26996066-6 2017 Inactivation of GSK-3beta by LiCl (lithium chloride) treatment notably increased MMP-2 activity, vascular endothelial growth factor expression and EMT of MCF-7 cells. Lithium Chloride 35-51 glycogen synthase kinase 3 beta Homo sapiens 16-25 26996066-6 2017 Inactivation of GSK-3beta by LiCl (lithium chloride) treatment notably increased MMP-2 activity, vascular endothelial growth factor expression and EMT of MCF-7 cells. Lithium Chloride 35-51 matrix metallopeptidase 2 Homo sapiens 81-86 26996066-6 2017 Inactivation of GSK-3beta by LiCl (lithium chloride) treatment notably increased MMP-2 activity, vascular endothelial growth factor expression and EMT of MCF-7 cells. Lithium Chloride 35-51 vascular endothelial growth factor A Homo sapiens 97-131 29442024-7 2017 Inhibition of GSK3beta by LiCl suppressed cyclin D1 phosphorylation and downregulation by EA-AKO. Lithium Chloride 26-30 glycogen synthase kinase 3 beta Homo sapiens 14-22 28742194-1 2017 OBJECTIVE: We aimed to discuss the mechanism of occurrence and progression of epilepsy through analyzing the expression changes of UCA1 and NF-Kb in temporal hippocampus and UCA1 in peripheral blood in rats with epilepsy induced by lithium chloride-pilocarpine. Lithium Chloride 232-248 nuclear factor kappa B subunit 1 Rattus norvegicus 140-145 28671055-5 2017 The biological behaviors of CCAT2 and its potential mechanisms in oral squamous cell carcinoma were explored by the combined use of CCAT2 knockdown technology and the Wnt/beta-catenin pathway agonist lithium chloride (LiCl). Lithium Chloride 200-216 colon cancer associated transcript 2 Homo sapiens 28-33 28671055-5 2017 The biological behaviors of CCAT2 and its potential mechanisms in oral squamous cell carcinoma were explored by the combined use of CCAT2 knockdown technology and the Wnt/beta-catenin pathway agonist lithium chloride (LiCl). Lithium Chloride 218-222 colon cancer associated transcript 2 Homo sapiens 28-33 28677426-6 2017 The signaling pathway downstream of DKK1 was characterized using the Wnt signaling pathway inhibitor, IWP2, and glycogen synthase kinase 3 beta inhibitor, LiCl. Lithium Chloride 155-159 dickkopf WNT signaling pathway inhibitor 1 Homo sapiens 36-40 28677426-12 2017 In addition, the inhibition of beta-catenin phosphorylation by glycogen synthase kinase 3 beta inhibitor, LiCl, significantly enhanced the migration and invasion capacities in DKK1-knockdown cell lines. Lithium Chloride 106-110 catenin beta 1 Homo sapiens 31-43 28677426-12 2017 In addition, the inhibition of beta-catenin phosphorylation by glycogen synthase kinase 3 beta inhibitor, LiCl, significantly enhanced the migration and invasion capacities in DKK1-knockdown cell lines. Lithium Chloride 106-110 glycogen synthase kinase 3 beta Homo sapiens 63-94 28677426-12 2017 In addition, the inhibition of beta-catenin phosphorylation by glycogen synthase kinase 3 beta inhibitor, LiCl, significantly enhanced the migration and invasion capacities in DKK1-knockdown cell lines. Lithium Chloride 106-110 dickkopf WNT signaling pathway inhibitor 1 Homo sapiens 176-180 28440457-6 2017 Although cell proliferating signals downregulated the transcription of PHB, treatment with lithium chloride, an analog of the Wnt signal, induced PHB level in various cell types. Lithium Chloride 91-107 prohibitin 1 Homo sapiens 71-74 28440457-6 2017 Although cell proliferating signals downregulated the transcription of PHB, treatment with lithium chloride, an analog of the Wnt signal, induced PHB level in various cell types. Lithium Chloride 91-107 prohibitin 1 Homo sapiens 146-149 28343033-7 2017 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin pathway, markedly attenuated QCT-induced mitochondrial apoptosis by partly restoring the expression levels of Wnt1 and beta-catenin. Lithium Chloride 13-29 catenin beta 1 Homo sapiens 58-70 28343033-7 2017 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin pathway, markedly attenuated QCT-induced mitochondrial apoptosis by partly restoring the expression levels of Wnt1 and beta-catenin. Lithium Chloride 13-29 Wnt family member 1 Homo sapiens 181-185 28343033-7 2017 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin pathway, markedly attenuated QCT-induced mitochondrial apoptosis by partly restoring the expression levels of Wnt1 and beta-catenin. Lithium Chloride 13-29 catenin beta 1 Homo sapiens 190-202 28343033-7 2017 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin pathway, markedly attenuated QCT-induced mitochondrial apoptosis by partly restoring the expression levels of Wnt1 and beta-catenin. Lithium Chloride 31-35 catenin beta 1 Homo sapiens 58-70 28343033-7 2017 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin pathway, markedly attenuated QCT-induced mitochondrial apoptosis by partly restoring the expression levels of Wnt1 and beta-catenin. Lithium Chloride 31-35 Wnt family member 1 Homo sapiens 181-185 28343033-7 2017 In addition, lithium chloride (LiCl), an activator of Wnt/beta-catenin pathway, markedly attenuated QCT-induced mitochondrial apoptosis by partly restoring the expression levels of Wnt1 and beta-catenin. Lithium Chloride 31-35 catenin beta 1 Homo sapiens 190-202 28977918-6 2017 Transfected cells were treated with lipopolysaccharide (LPS) alone, or in combination with a TBK1 inhibitor (LiCl). Lithium Chloride 109-113 TANK binding kinase 1 Sus scrofa 93-97 28575066-7 2017 In the course of this, LiCl induced inhibitory glycogen synthase kinase-3beta (GSK-3beta) serine 9 phosphorylation, whereas glioma associated oncogene family 1 (GLI1) protein expression was particularly reduced by combined ATO and LiCl treatment in RD and RH-30 cell lines, showing high rates of apoptotic cell death. Lithium Chloride 23-27 glycogen synthase kinase 3 beta Homo sapiens 47-77 28575066-7 2017 In the course of this, LiCl induced inhibitory glycogen synthase kinase-3beta (GSK-3beta) serine 9 phosphorylation, whereas glioma associated oncogene family 1 (GLI1) protein expression was particularly reduced by combined ATO and LiCl treatment in RD and RH-30 cell lines, showing high rates of apoptotic cell death. Lithium Chloride 23-27 glycogen synthase kinase 3 beta Homo sapiens 79-88 29442024-7 2017 Inhibition of GSK3beta by LiCl suppressed cyclin D1 phosphorylation and downregulation by EA-AKO. Lithium Chloride 26-30 cyclin D1 Homo sapiens 42-51 28415676-3 2017 Here, the expression pattern and subcellular distribution of adenosine A1 receptor were detected by Western blot analysis and double-labeling immunofluorescence staining in Lithium Chloride-Pilocarpine induced epileptic rat model. Lithium Chloride 173-189 adenosine A1 receptor Rattus norvegicus 61-82 28107808-6 2017 beta-catenin expression was partially recovered by treatment with lithium chloride, a canonical Wnt pathway activator. Lithium Chloride 66-82 catenin beta 1 Rattus norvegicus 0-12 28323090-0 2017 c-Fos activity in the insular cortex, nucleus accumbens and basolateral amygdala following the intraperitoneal injection of saccharin and lithium chloride. Lithium Chloride 138-154 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 28323090-1 2017 This study examined c-Fos expression in selected brain areas consequent to intraperitoneal (IP) administration of saccharin and lithium chloride. Lithium Chloride 128-144 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 20-25 28366776-0 2017 Involvement of Akt/GSK3beta/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment. Lithium Chloride 141-157 thymoma viral proto-oncogene 1 Mus musculus 15-18 28366776-0 2017 Involvement of Akt/GSK3beta/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment. Lithium Chloride 141-157 glycogen synthase kinase 3 beta Mus musculus 19-27 28366776-0 2017 Involvement of Akt/GSK3beta/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment. Lithium Chloride 141-157 cAMP responsive element binding protein 1 Mus musculus 28-32 28366776-5 2017 Moreover, the combined application of AST and LiCl had synergistic therapeutic effects compared to LiCl and AST treatment alone, the expression of p-GSK3beta, p-CREB, p-PI3K and p-Akt after combined LiCl-AST treatment were significantly higher than that with single drug application. Lithium Chloride 46-50 glycogen synthase kinase 3 beta Mus musculus 149-157 28366776-5 2017 Moreover, the combined application of AST and LiCl had synergistic therapeutic effects compared to LiCl and AST treatment alone, the expression of p-GSK3beta, p-CREB, p-PI3K and p-Akt after combined LiCl-AST treatment were significantly higher than that with single drug application. Lithium Chloride 46-50 cAMP responsive element binding protein 1 Mus musculus 161-165 28366776-5 2017 Moreover, the combined application of AST and LiCl had synergistic therapeutic effects compared to LiCl and AST treatment alone, the expression of p-GSK3beta, p-CREB, p-PI3K and p-Akt after combined LiCl-AST treatment were significantly higher than that with single drug application. Lithium Chloride 46-50 thymoma viral proto-oncogene 1 Mus musculus 180-183 28459216-5 2017 Introduction of LiCl, a glycogen synthase kinase 3beta inhibitor, rescued the Abrus agglutinin-stimulated inhibition of beta-catenin and phosphorylated glycogen synthase kinase 3beta in FaDu cell-derived orospheres confirming importance of Wnt signaling in Abrus agglutinin-mediated inhibition of stemness. Lithium Chloride 16-20 glycogen synthase kinase 3 beta Homo sapiens 24-54 28459216-5 2017 Introduction of LiCl, a glycogen synthase kinase 3beta inhibitor, rescued the Abrus agglutinin-stimulated inhibition of beta-catenin and phosphorylated glycogen synthase kinase 3beta in FaDu cell-derived orospheres confirming importance of Wnt signaling in Abrus agglutinin-mediated inhibition of stemness. Lithium Chloride 16-20 catenin beta 1 Homo sapiens 120-132 28459216-5 2017 Introduction of LiCl, a glycogen synthase kinase 3beta inhibitor, rescued the Abrus agglutinin-stimulated inhibition of beta-catenin and phosphorylated glycogen synthase kinase 3beta in FaDu cell-derived orospheres confirming importance of Wnt signaling in Abrus agglutinin-mediated inhibition of stemness. Lithium Chloride 16-20 glycogen synthase kinase 3 beta Homo sapiens 152-182 28593132-0 2017 Activation of Wnt/beta-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging. Lithium Chloride 44-60 Wnt family member 2 Rattus norvegicus 14-17 28593132-0 2017 Activation of Wnt/beta-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging. Lithium Chloride 44-60 catenin beta 1 Rattus norvegicus 18-30 28593132-5 2017 Moreover, lithium chloride (Licl), an activator of Wnt signaling pathway, was administered long term to 15-month-old d-gal-treated rats. Lithium Chloride 10-26 Wnt family member 2 Rattus norvegicus 51-54 28593132-5 2017 Moreover, lithium chloride (Licl), an activator of Wnt signaling pathway, was administered long term to 15-month-old d-gal-treated rats. Lithium Chloride 28-32 Wnt family member 2 Rattus norvegicus 51-54 28593132-6 2017 Activation of Wnt/beta-catenin signaling by Licl attenuated d-gal-induced auditory cortex apoptosis and neurodegeneration. Lithium Chloride 44-48 Wnt family member 2 Rattus norvegicus 14-17 28593132-6 2017 Activation of Wnt/beta-catenin signaling by Licl attenuated d-gal-induced auditory cortex apoptosis and neurodegeneration. Lithium Chloride 44-48 catenin beta 1 Rattus norvegicus 18-30 28595035-6 2017 Inhibiting GSK-3beta and Cdk5 using lithium chloride and roscovitine also alleviated axonal impairment induced by PTZ. Lithium Chloride 36-52 glycogen synthase kinase 3 beta Rattus norvegicus 11-20 28595035-6 2017 Inhibiting GSK-3beta and Cdk5 using lithium chloride and roscovitine also alleviated axonal impairment induced by PTZ. Lithium Chloride 36-52 cyclin-dependent kinase 5 Rattus norvegicus 25-29 28338064-0 2017 Acceleration of bone regeneration by activating Wnt/beta-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis. Lithium Chloride 110-126 Wnt family member 2 Rattus norvegicus 48-51 28338064-0 2017 Acceleration of bone regeneration by activating Wnt/beta-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis. Lithium Chloride 110-126 catenin beta 1 Rattus norvegicus 52-64 28093328-4 2017 Mechanistically, cinnamaldehyde imitated the suppressive effect of XAV939 on cell motility and EMT which could be impaired by LiCl. Lithium Chloride 126-130 IL2 inducible T cell kinase Homo sapiens 95-98 28300015-9 2017 Finally, the administration of LiCl, an enhancer of the Wnt-signalling pathway showed similar experimentally beneficial effects, suggesting FRZB silencing or LiCl administration as potential therapeutic targets, though further studies are required. Lithium Chloride 31-35 frizzled related protein Homo sapiens 140-144 28386329-5 2017 Our data indicated that LiCl treatment could attenuates BSCB disruption and improved the recovery of functional locomotion in rats SCI model, reduced the structure damage and number loss of microvessels, increased the expressions of junction proteins, including p120, beta-catenin, occludin, and claudin-5, via reversed the upregulated ER stress associated proteins. Lithium Chloride 24-28 bromodomain containing 8 Rattus norvegicus 262-266 28386329-5 2017 Our data indicated that LiCl treatment could attenuates BSCB disruption and improved the recovery of functional locomotion in rats SCI model, reduced the structure damage and number loss of microvessels, increased the expressions of junction proteins, including p120, beta-catenin, occludin, and claudin-5, via reversed the upregulated ER stress associated proteins. Lithium Chloride 24-28 catenin beta 1 Rattus norvegicus 268-280 28386329-5 2017 Our data indicated that LiCl treatment could attenuates BSCB disruption and improved the recovery of functional locomotion in rats SCI model, reduced the structure damage and number loss of microvessels, increased the expressions of junction proteins, including p120, beta-catenin, occludin, and claudin-5, via reversed the upregulated ER stress associated proteins. Lithium Chloride 24-28 occludin Rattus norvegicus 282-290 28386329-5 2017 Our data indicated that LiCl treatment could attenuates BSCB disruption and improved the recovery of functional locomotion in rats SCI model, reduced the structure damage and number loss of microvessels, increased the expressions of junction proteins, including p120, beta-catenin, occludin, and claudin-5, via reversed the upregulated ER stress associated proteins. Lithium Chloride 24-28 claudin 5 Rattus norvegicus 296-305 28291828-9 2017 Mechanistically, GSK3beta pathway was found to be a major player, whereby inhibiting it with lithium chloride (LiCl) resulted in complete blockage of lipid accumulation, accompanied by complete down regulation of PLIN1 and ADN gene expression. Lithium Chloride 93-109 glycogen synthase kinase 3 beta Mus musculus 17-25 28291828-9 2017 Mechanistically, GSK3beta pathway was found to be a major player, whereby inhibiting it with lithium chloride (LiCl) resulted in complete blockage of lipid accumulation, accompanied by complete down regulation of PLIN1 and ADN gene expression. Lithium Chloride 93-109 perilipin 1 Mus musculus 213-218 28291828-9 2017 Mechanistically, GSK3beta pathway was found to be a major player, whereby inhibiting it with lithium chloride (LiCl) resulted in complete blockage of lipid accumulation, accompanied by complete down regulation of PLIN1 and ADN gene expression. Lithium Chloride 93-109 complement factor D (adipsin) Mus musculus 223-226 28291828-9 2017 Mechanistically, GSK3beta pathway was found to be a major player, whereby inhibiting it with lithium chloride (LiCl) resulted in complete blockage of lipid accumulation, accompanied by complete down regulation of PLIN1 and ADN gene expression. Lithium Chloride 111-115 glycogen synthase kinase 3 beta Mus musculus 17-25 28291828-9 2017 Mechanistically, GSK3beta pathway was found to be a major player, whereby inhibiting it with lithium chloride (LiCl) resulted in complete blockage of lipid accumulation, accompanied by complete down regulation of PLIN1 and ADN gene expression. Lithium Chloride 111-115 perilipin 1 Mus musculus 213-218 28291828-9 2017 Mechanistically, GSK3beta pathway was found to be a major player, whereby inhibiting it with lithium chloride (LiCl) resulted in complete blockage of lipid accumulation, accompanied by complete down regulation of PLIN1 and ADN gene expression. Lithium Chloride 111-115 complement factor D (adipsin) Mus musculus 223-226 28076890-10 2017 Finally, LiCl mediated activation of WNT signaling pathway demonstrated rescue of Ti particle facilitated suppression of Osterix expression in mice calvaria. Lithium Chloride 9-13 Sp7 transcription factor 7 Mus musculus 121-128 27991911-10 2017 Lithium chloride, an inhibitor of GSK-3beta, did not provide additional attenuated NGF levels compared with atrasentan alone. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Rattus norvegicus 34-43 28454326-7 2017 TRIM24 knockdown decreased the expression of Wnt/beta-catenin target genes, whereas the activation of Wnt/beta-catenin signaling by lithium chloride reversed the effects of TRIM24 knockdown. Lithium Chloride 132-148 catenin beta 1 Homo sapiens 106-118 28098905-10 2017 Additionally, our results displayed that Licl had antitumor activity against PC-3 through the inhibition of Wnt/beta-catenin pathway. Lithium Chloride 41-45 catenin beta 1 Homo sapiens 112-124 28454326-7 2017 TRIM24 knockdown decreased the expression of Wnt/beta-catenin target genes, whereas the activation of Wnt/beta-catenin signaling by lithium chloride reversed the effects of TRIM24 knockdown. Lithium Chloride 132-148 tripartite motif containing 24 Homo sapiens 173-179 28173817-8 2017 Similar to lithium chloride (LiCl, a Wnt/beta-catenin pathway activator), ox-LDL up-regulated the expression of beta-catenin, Dvl-1 and Cyclin D1, markers of Wnt/beta-catenin pathway activation. Lithium Chloride 29-33 catenin beta 1 Homo sapiens 41-53 28077724-7 2017 More importantly, treatment with Wnt3a, LiCl, or TDZD-8, which activates the beta-catenin-mediated Wnt signaling pathway, rescued microglia survival and microgliosis in Trem2-/- microglia and/or in Trem2-/- mouse brain. Lithium Chloride 40-44 catenin (cadherin associated protein), beta 1 Mus musculus 77-89 28077724-7 2017 More importantly, treatment with Wnt3a, LiCl, or TDZD-8, which activates the beta-catenin-mediated Wnt signaling pathway, rescued microglia survival and microgliosis in Trem2-/- microglia and/or in Trem2-/- mouse brain. Lithium Chloride 40-44 triggering receptor expressed on myeloid cells 2 Mus musculus 169-174 28077724-7 2017 More importantly, treatment with Wnt3a, LiCl, or TDZD-8, which activates the beta-catenin-mediated Wnt signaling pathway, rescued microglia survival and microgliosis in Trem2-/- microglia and/or in Trem2-/- mouse brain. Lithium Chloride 40-44 triggering receptor expressed on myeloid cells 2 Mus musculus 198-203 28060847-8 2017 The results indicated that SB216763 was more effective than LiCl as evidenced by a higher up-regulation of the expression of cartilage-specific markers, including Sox9, ACAN, Col2a1 as well as GAG accumulation. Lithium Chloride 60-64 SRY-box transcription factor 9 Homo sapiens 163-167 28217097-5 2017 Furthermore, treatment of fibroblasts with lithium chloride or IWR-1, an inducer and inhibitor of the Wnt signaling pathway, respectively, promoted and inhibited cell migration. Lithium Chloride 43-59 Wnt family member 2B Homo sapiens 102-105 27668462-7 2017 Activation of beta-catenin signaling using lithium chloride resulted in worsened fibrosis in wild-type mice, further supporting that the effects of loss of Lrp5 are directly mediated by Wnt/beta-catenin signaling. Lithium Chloride 43-59 catenin (cadherin associated protein), beta 1 Mus musculus 14-26 27468916-5 2017 In rats, we assessed Fos response to lithium chloride (LiCl), beta-carboline, naloxone, lipopolysaccharide (LPS), inflammatory pain, neuropathic pain, foot-shock, restraint stress, forced swimming, predator odor, and opiate withdrawal. Lithium Chloride 37-53 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 21-24 28067368-5 2017 We also showed that activation of the Wnt/beta-catenin signal pathway by using lithium chloride (LiCl) significantly attenuated arginine-induced upregulation of PPARgamma and increased the phospho-beta-catenin level. Lithium Chloride 79-95 catenin beta 1 Sus scrofa 42-54 28067368-5 2017 We also showed that activation of the Wnt/beta-catenin signal pathway by using lithium chloride (LiCl) significantly attenuated arginine-induced upregulation of PPARgamma and increased the phospho-beta-catenin level. Lithium Chloride 79-95 peroxisome proliferator activated receptor gamma Sus scrofa 161-170 28067368-5 2017 We also showed that activation of the Wnt/beta-catenin signal pathway by using lithium chloride (LiCl) significantly attenuated arginine-induced upregulation of PPARgamma and increased the phospho-beta-catenin level. Lithium Chloride 79-95 catenin beta 1 Sus scrofa 197-209 28067368-5 2017 We also showed that activation of the Wnt/beta-catenin signal pathway by using lithium chloride (LiCl) significantly attenuated arginine-induced upregulation of PPARgamma and increased the phospho-beta-catenin level. Lithium Chloride 97-101 catenin beta 1 Sus scrofa 42-54 28067368-5 2017 We also showed that activation of the Wnt/beta-catenin signal pathway by using lithium chloride (LiCl) significantly attenuated arginine-induced upregulation of PPARgamma and increased the phospho-beta-catenin level. Lithium Chloride 97-101 peroxisome proliferator activated receptor gamma Sus scrofa 161-170 28067368-5 2017 We also showed that activation of the Wnt/beta-catenin signal pathway by using lithium chloride (LiCl) significantly attenuated arginine-induced upregulation of PPARgamma and increased the phospho-beta-catenin level. Lithium Chloride 97-101 catenin beta 1 Sus scrofa 197-209 28123643-7 2017 We also showed that the GSK3beta inhibitor LiCl can partly disable SAHF formation through the HMGA2 overexpression in WI38 cells. Lithium Chloride 43-47 glycogen synthase kinase 3 beta Homo sapiens 24-32 28123643-7 2017 We also showed that the GSK3beta inhibitor LiCl can partly disable SAHF formation through the HMGA2 overexpression in WI38 cells. Lithium Chloride 43-47 high mobility group AT-hook 2 Homo sapiens 94-99 28060847-8 2017 The results indicated that SB216763 was more effective than LiCl as evidenced by a higher up-regulation of the expression of cartilage-specific markers, including Sox9, ACAN, Col2a1 as well as GAG accumulation. Lithium Chloride 60-64 aggrecan Homo sapiens 169-173 28060847-8 2017 The results indicated that SB216763 was more effective than LiCl as evidenced by a higher up-regulation of the expression of cartilage-specific markers, including Sox9, ACAN, Col2a1 as well as GAG accumulation. Lithium Chloride 60-64 collagen type II alpha 1 chain Homo sapiens 175-181 27908414-3 2017 We used an inducible canonical wnt signaling system that utilizes LiCl (GSK-3beta inhibitor). Lithium Chloride 66-70 glycogen synthase kinase 3 beta Homo sapiens 72-81 28286769-7 2017 Activation of beta-catenin with LiCl led to increased expression of Runx2 and Collagen I and reduction of C/EBPalpha and PPARgamma expression in BMSCs. Lithium Chloride 32-36 catenin beta 1 Rattus norvegicus 14-26 28286769-7 2017 Activation of beta-catenin with LiCl led to increased expression of Runx2 and Collagen I and reduction of C/EBPalpha and PPARgamma expression in BMSCs. Lithium Chloride 32-36 RUNX family transcription factor 2 Rattus norvegicus 68-73 28286769-7 2017 Activation of beta-catenin with LiCl led to increased expression of Runx2 and Collagen I and reduction of C/EBPalpha and PPARgamma expression in BMSCs. Lithium Chloride 32-36 CCAAT/enhancer binding protein alpha Rattus norvegicus 106-116 28286769-7 2017 Activation of beta-catenin with LiCl led to increased expression of Runx2 and Collagen I and reduction of C/EBPalpha and PPARgamma expression in BMSCs. Lithium Chloride 32-36 peroxisome proliferator-activated receptor gamma Rattus norvegicus 121-130 28427047-7 2017 A detailed study of the mechanism suggested reduction in the beta-catenin and p-GSK3b (Ser 9) levels to be the driving cause of this phenomenon, which was reversed upon co-activation with higher concentrations of LiCl. Lithium Chloride 213-217 catenin beta 1 Homo sapiens 61-73 27758766-7 2016 We found that Dvl3 depletion in dvl1-/- mice mimicked the fzd7ECKO vascular phenotype and demonstrated that Fzd7 acted via beta-catenin activation by showing that LiCl treatment rescued impairment in tip and stalk cell phenotypes induced in fzd7 mutants. Lithium Chloride 163-167 dishevelled segment polarity protein 3 Mus musculus 14-18 28078012-1 2016 Glycogen synthase kinase 3beta (GSK3beta) inhibitors, especially the mood stabilizer lithium chloride, are also used as neuroprotective or anti-inflammatory agents. Lithium Chloride 85-101 glycogen synthase kinase 3 beta Mus musculus 0-30 28078012-1 2016 Glycogen synthase kinase 3beta (GSK3beta) inhibitors, especially the mood stabilizer lithium chloride, are also used as neuroprotective or anti-inflammatory agents. Lithium Chloride 85-101 glycogen synthase kinase 3 beta Mus musculus 32-40 28078012-6 2016 We showed by ChIP experiments that LiCl treatment drives beta-catenin to bind to T-cell factor/lymphoid-enhancer factor response elements identified in myelin-related genes. Lithium Chloride 35-39 catenin (cadherin associated protein), beta 1 Mus musculus 57-69 28194187-9 2017 Activation of the Wnt/beta-catenin pathway by LiCl or BIO modified the effects of hypoxia on the differentiation and self-renewal of MMSCs. Lithium Chloride 46-50 Wnt family member 4 Rattus norvegicus 18-21 28194187-9 2017 Activation of the Wnt/beta-catenin pathway by LiCl or BIO modified the effects of hypoxia on the differentiation and self-renewal of MMSCs. Lithium Chloride 46-50 catenin beta 1 Rattus norvegicus 22-34 27758766-7 2016 We found that Dvl3 depletion in dvl1-/- mice mimicked the fzd7ECKO vascular phenotype and demonstrated that Fzd7 acted via beta-catenin activation by showing that LiCl treatment rescued impairment in tip and stalk cell phenotypes induced in fzd7 mutants. Lithium Chloride 163-167 dishevelled segment polarity protein 1 Mus musculus 32-36 27758766-7 2016 We found that Dvl3 depletion in dvl1-/- mice mimicked the fzd7ECKO vascular phenotype and demonstrated that Fzd7 acted via beta-catenin activation by showing that LiCl treatment rescued impairment in tip and stalk cell phenotypes induced in fzd7 mutants. Lithium Chloride 163-167 frizzled class receptor 7 Mus musculus 108-112 27758766-7 2016 We found that Dvl3 depletion in dvl1-/- mice mimicked the fzd7ECKO vascular phenotype and demonstrated that Fzd7 acted via beta-catenin activation by showing that LiCl treatment rescued impairment in tip and stalk cell phenotypes induced in fzd7 mutants. Lithium Chloride 163-167 catenin (cadherin associated protein), beta 1 Mus musculus 123-135 27758766-7 2016 We found that Dvl3 depletion in dvl1-/- mice mimicked the fzd7ECKO vascular phenotype and demonstrated that Fzd7 acted via beta-catenin activation by showing that LiCl treatment rescued impairment in tip and stalk cell phenotypes induced in fzd7 mutants. Lithium Chloride 163-167 frizzled class receptor 7 Mus musculus 58-62 27018151-5 2016 Furthermore, blockage of GSK-3beta with lithium chloride significantly attenuated both the PFOS-induced downregulation of GSK-3beta/beta-catenin and the proliferative impairment of C17.2 cells. Lithium Chloride 40-56 glycogen synthase kinase 3 beta Mus musculus 25-34 27018151-5 2016 Furthermore, blockage of GSK-3beta with lithium chloride significantly attenuated both the PFOS-induced downregulation of GSK-3beta/beta-catenin and the proliferative impairment of C17.2 cells. Lithium Chloride 40-56 glycogen synthase kinase 3 beta Mus musculus 122-131 27018151-5 2016 Furthermore, blockage of GSK-3beta with lithium chloride significantly attenuated both the PFOS-induced downregulation of GSK-3beta/beta-catenin and the proliferative impairment of C17.2 cells. Lithium Chloride 40-56 catenin (cadherin associated protein), beta 1 Mus musculus 132-144 27318088-9 2016 Furthermore, capsaicin still enhanced beta-catenin phosphorylation in cells treated with a GSK3 inhibitor, LiCl but not in those treated with a phosphatase inhibitor, okadaic acid. Lithium Chloride 107-111 catenin beta 1 L homeolog Xenopus laevis 38-50 27870504-0 2016 Chronic LiCl pretreatment suppresses thrombin-stimulated intracellular calcium mobilization through TRPC3 in astroglioma cells. Lithium Chloride 8-12 coagulation factor II, thrombin Homo sapiens 37-45 27870504-0 2016 Chronic LiCl pretreatment suppresses thrombin-stimulated intracellular calcium mobilization through TRPC3 in astroglioma cells. Lithium Chloride 8-12 transient receptor potential cation channel subfamily C member 3 Homo sapiens 100-105 27870504-9 2016 RESULTS: In this cell model, thrombin-stimulated Ca2+ mobilization, and both TRPC3 and S100B expression were suppressed by chronic LiCl pretreatment and the knockdown of TRPC3. Lithium Chloride 131-135 coagulation factor II, thrombin Homo sapiens 29-37 27870504-9 2016 RESULTS: In this cell model, thrombin-stimulated Ca2+ mobilization, and both TRPC3 and S100B expression were suppressed by chronic LiCl pretreatment and the knockdown of TRPC3. Lithium Chloride 131-135 transient receptor potential cation channel subfamily C member 3 Homo sapiens 77-82 27870504-9 2016 RESULTS: In this cell model, thrombin-stimulated Ca2+ mobilization, and both TRPC3 and S100B expression were suppressed by chronic LiCl pretreatment and the knockdown of TRPC3. Lithium Chloride 131-135 S100 calcium binding protein B Homo sapiens 87-92 27870504-11 2016 CONCLUSIONS: The reduced Ca2+ mobilization and S100B expression levels following chronic LiCl pretreatment and in TRPC3Low cells support the notion that TRPC3 modulates S100B expression and is the target of the LiCl effect. Lithium Chloride 89-93 S100 calcium binding protein B Homo sapiens 47-52 27870504-11 2016 CONCLUSIONS: The reduced Ca2+ mobilization and S100B expression levels following chronic LiCl pretreatment and in TRPC3Low cells support the notion that TRPC3 modulates S100B expression and is the target of the LiCl effect. Lithium Chloride 89-93 transient receptor potential cation channel subfamily C member 3 Homo sapiens 153-158 27870504-11 2016 CONCLUSIONS: The reduced Ca2+ mobilization and S100B expression levels following chronic LiCl pretreatment and in TRPC3Low cells support the notion that TRPC3 modulates S100B expression and is the target of the LiCl effect. Lithium Chloride 89-93 S100 calcium binding protein B Homo sapiens 169-174 27870504-11 2016 CONCLUSIONS: The reduced Ca2+ mobilization and S100B expression levels following chronic LiCl pretreatment and in TRPC3Low cells support the notion that TRPC3 modulates S100B expression and is the target of the LiCl effect. Lithium Chloride 211-215 transient receptor potential cation channel subfamily C member 3 Homo sapiens 114-119 27870504-11 2016 CONCLUSIONS: The reduced Ca2+ mobilization and S100B expression levels following chronic LiCl pretreatment and in TRPC3Low cells support the notion that TRPC3 modulates S100B expression and is the target of the LiCl effect. Lithium Chloride 211-215 transient receptor potential cation channel subfamily C member 3 Homo sapiens 153-158 27870504-11 2016 CONCLUSIONS: The reduced Ca2+ mobilization and S100B expression levels following chronic LiCl pretreatment and in TRPC3Low cells support the notion that TRPC3 modulates S100B expression and is the target of the LiCl effect. Lithium Chloride 211-215 S100 calcium binding protein B Homo sapiens 169-174 27917283-8 2016 LiCl reduced CAT activity and increased cell viability in Almal-treated cells, without significant effect on apoptosis (P=0.74). Lithium Chloride 0-4 catalase Rattus norvegicus 13-16 27622390-7 2016 The new compounds M(BH4)3 (M = La, Ce) can be combined with LiCl in an addition reaction to form LiM(BH4)3Cl also known as Li4[M4(BH4)12Cl4]; the latter contains the unique tetranuclear cluster [M4(BH4)12Cl4]4- and shows high Li-ion conductivity. Lithium Chloride 60-64 PDZ and LIM domain 5 Homo sapiens 97-100 27251162-4 2016 Activation of the Wnt/beta-catenin pathway in differentiating myoblasts, using lithium chloride supplementation, increased both the number and size of C2C12 myotubes. Lithium Chloride 79-95 wingless-type MMTV integration site family, member 3A Mus musculus 18-21 27251162-4 2016 Activation of the Wnt/beta-catenin pathway in differentiating myoblasts, using lithium chloride supplementation, increased both the number and size of C2C12 myotubes. Lithium Chloride 79-95 catenin (cadherin associated protein), beta 1 Mus musculus 22-34 27251162-8 2016 Additionally, LiCl treatment resulted in enhanced expression of beta-catenin in pre-differentiating myoblast cultures. Lithium Chloride 14-18 catenin (cadherin associated protein), beta 1 Mus musculus 64-76 27721245-6 2016 Finally, the mRNA expression of Cyr61 was determined in ESCC cells after lithium chloride (LiCl) treatment, which activated intrinsic Wnt/beta-catenin signaling. Lithium Chloride 73-89 cellular communication network factor 1 Homo sapiens 32-37 27721245-6 2016 Finally, the mRNA expression of Cyr61 was determined in ESCC cells after lithium chloride (LiCl) treatment, which activated intrinsic Wnt/beta-catenin signaling. Lithium Chloride 73-89 catenin beta 1 Homo sapiens 138-150 27721245-6 2016 Finally, the mRNA expression of Cyr61 was determined in ESCC cells after lithium chloride (LiCl) treatment, which activated intrinsic Wnt/beta-catenin signaling. Lithium Chloride 91-95 cellular communication network factor 1 Homo sapiens 32-37 27721245-6 2016 Finally, the mRNA expression of Cyr61 was determined in ESCC cells after lithium chloride (LiCl) treatment, which activated intrinsic Wnt/beta-catenin signaling. Lithium Chloride 91-95 catenin beta 1 Homo sapiens 138-150 27721245-9 2016 In addition, the expression of Cyr61 could be modulated by LiCl, an activator of Wnt/beta-catenin signaling. Lithium Chloride 59-63 cellular communication network factor 1 Homo sapiens 31-36 27721245-9 2016 In addition, the expression of Cyr61 could be modulated by LiCl, an activator of Wnt/beta-catenin signaling. Lithium Chloride 59-63 catenin beta 1 Homo sapiens 85-97 27703531-0 2016 Lithium chloride has a biphasic effect on prostate cancer stem cells and a proportional effect on midkine levels. Lithium Chloride 0-16 midkine Homo sapiens 98-105 27703531-12 2016 To the best of our knowledge, the present study was the first to show the effect of LiCl on PCa stem cells through MK. Lithium Chloride 84-88 midkine Homo sapiens 115-117 27318088-9 2016 Furthermore, capsaicin still enhanced beta-catenin phosphorylation in cells treated with a GSK3 inhibitor, LiCl but not in those treated with a phosphatase inhibitor, okadaic acid. Lithium Chloride 107-111 glycogen synthase kinase 3 beta L homeolog Xenopus laevis 91-95 27367429-6 2016 LiCl was less effective in decreasing the MK and B cell lymphoma-2 (Bcl-2) levels compared with the combination treatment. Lithium Chloride 0-4 BCL2 apoptosis regulator Homo sapiens 49-66 27490211-13 2016 Anti-GSK3 beta, pGSK3 beta, Bcl-2, Akt-1, p-Akt1 protein levels were observed with cells exposed to Tideglusib and Lithium chloride. Lithium Chloride 115-131 glycogen synthase kinase 3 beta Homo sapiens 5-14 27490211-13 2016 Anti-GSK3 beta, pGSK3 beta, Bcl-2, Akt-1, p-Akt1 protein levels were observed with cells exposed to Tideglusib and Lithium chloride. Lithium Chloride 115-131 BCL2 apoptosis regulator Homo sapiens 28-33 27490211-13 2016 Anti-GSK3 beta, pGSK3 beta, Bcl-2, Akt-1, p-Akt1 protein levels were observed with cells exposed to Tideglusib and Lithium chloride. Lithium Chloride 115-131 AKT serine/threonine kinase 1 Homo sapiens 35-40 27618015-0 2016 Six2 Is a Coordinator of LiCl-Induced Cell Proliferation and Apoptosis. Lithium Chloride 25-29 SIX homeobox 2 Homo sapiens 0-4 27618015-13 2016 However, the abnormal rise of apoptosis at 30 mM of LiCl concentration implies that it might be the reduction of GSK3beta that increased cell apoptosis. Lithium Chloride 52-56 glycogen synthase kinase 3 beta Homo sapiens 113-121 27618015-14 2016 Together, these demonstrate that LiCl can induce the proliferation and apoptosis of MM cells coordinating with Six2. Lithium Chloride 33-37 SIX homeobox 2 Homo sapiens 111-115 27431999-12 2016 While LiCl, the inhibitor of GSK-3beta decreased PA-induced apoptosis, accompany with increased nucleus level of beta-Arr2. Lithium Chloride 6-10 glycogen synthase kinase 3 beta Rattus norvegicus 29-38 27431999-12 2016 While LiCl, the inhibitor of GSK-3beta decreased PA-induced apoptosis, accompany with increased nucleus level of beta-Arr2. Lithium Chloride 6-10 arrestin, beta 2, pseudogene Rattus norvegicus 113-122 27377850-7 2016 Consistently, activation of the Wnt/beta-catenin signaling pathway by LiCl and DeltaN89beta-catenin rescued the inhibitory effect of miR-124 on the chemotactic migration of rMSCs toward HGF, while inhibition of Wnt/beta-catenin signaling by FH535 abrogated the enhanced chemotactic response achieved by the miR-124 inhibitor. Lithium Chloride 70-74 catenin beta 1 Rattus norvegicus 36-48 27367429-6 2016 LiCl was less effective in decreasing the MK and B cell lymphoma-2 (Bcl-2) levels compared with the combination treatment. Lithium Chloride 0-4 BCL2 apoptosis regulator Homo sapiens 68-73 27388762-10 2016 Both EtOH- and LiCl-induced CTA significantly enhanced cFos expression in the RMTg and LHb but not the hippocampus. Lithium Chloride 15-19 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 55-59 30263387-0 2016 Lithium chloride"s inhibition of 3T3-L1 cell differentiation by regulating the Wnt/beta-catenin pathway and enhancing villin 2 expression. Lithium Chloride 0-16 catenin (cadherin associated protein), beta 1 Mus musculus 83-95 30263387-0 2016 Lithium chloride"s inhibition of 3T3-L1 cell differentiation by regulating the Wnt/beta-catenin pathway and enhancing villin 2 expression. Lithium Chloride 0-16 ezrin Mus musculus 118-126 30263387-1 2016 The aim of this study is to reveal the relation among villin 2, Wnt/beta-catenin, and adipogenesis by adding appropriate lithium chloride (LiCl). Lithium Chloride 139-143 ezrin Mus musculus 54-62 27470348-10 2016 LiCl, a potent GSK-3beta inhibitor, can obviously reverse EGF induced up regulation of p65 phosphorylation. Lithium Chloride 0-4 glycogen synthase kinase 3 beta Homo sapiens 15-24 27470348-10 2016 LiCl, a potent GSK-3beta inhibitor, can obviously reverse EGF induced up regulation of p65 phosphorylation. Lithium Chloride 0-4 epidermal growth factor Homo sapiens 58-61 27470348-10 2016 LiCl, a potent GSK-3beta inhibitor, can obviously reverse EGF induced up regulation of p65 phosphorylation. Lithium Chloride 0-4 RELA proto-oncogene, NF-kB subunit Homo sapiens 87-90 27150989-4 2016 RESULTS: 20 micromol/L XAV-939 and 20 mmol/L LiCl could effectively inhibit and activate Wnt signalling pathway of HL-60 cells respectively, could significantly down- and up-regulate the expression of cyclinD1, TCF1 and c-Jun genes (P < 0.05) and proteins (P < 0.05); moreover, the number of CD10(+) HL-60 cells in these conditions was below 1%, no early apoptosis of HL-60 cells was found. Lithium Chloride 45-49 cyclin D1 Homo sapiens 201-209 27068032-6 2016 The results showed that neonatal sevoflurane exposure induced caspase-3 activation and histopathological changes in hippocampus can be attenuated by lithium chloride. Lithium Chloride 149-165 caspase 3 Rattus norvegicus 62-71 27688851-4 2016 We have previously shown that the GSK3 inhibitor, lithium chloride (LiCl), was able to suppress parasitaemia development in a rodent model of malarial infection. Lithium Chloride 50-66 glycogen synthase kinase 3 beta Mus musculus 34-38 27688851-4 2016 We have previously shown that the GSK3 inhibitor, lithium chloride (LiCl), was able to suppress parasitaemia development in a rodent model of malarial infection. Lithium Chloride 68-72 glycogen synthase kinase 3 beta Mus musculus 34-38 27257912-11 2016 The combination of osteo/odontogenic stimuli and Lithium Chloride decreased mRNA expression of Gsk3beta, recovered by Procaine. Lithium Chloride 49-65 glycogen synthase kinase 3 beta Rattus norvegicus 95-103 27083516-5 2016 Inhibition of Gsk3b using lithium chloride in Runx2-overexpressing osteoporotic female mice rescued the Wnt/beta-catenin signaling in vivo and completely restored trabecular bone volume by increasing bone formation and decreasing bone resorption. Lithium Chloride 26-42 glycogen synthase kinase 3 beta Mus musculus 14-19 27083516-5 2016 Inhibition of Gsk3b using lithium chloride in Runx2-overexpressing osteoporotic female mice rescued the Wnt/beta-catenin signaling in vivo and completely restored trabecular bone volume by increasing bone formation and decreasing bone resorption. Lithium Chloride 26-42 runt related transcription factor 2 Mus musculus 46-51 27083516-5 2016 Inhibition of Gsk3b using lithium chloride in Runx2-overexpressing osteoporotic female mice rescued the Wnt/beta-catenin signaling in vivo and completely restored trabecular bone volume by increasing bone formation and decreasing bone resorption. Lithium Chloride 26-42 catenin (cadherin associated protein), beta 1 Mus musculus 108-120 27083516-6 2016 The activation of Wnt/beta-catenin signaling by lithium chloride treatment reduced the number and activity of bone marrow-derived osteoclast-like cells in vitro, suggesting that the restoration of trabecular bone in vivo was due to decreased bone resorption, consistent with the reduced receptor activator of NF-kappaB ligand/osteoprotegerin ratio in Runx2-overexpressing osteoblasts. Lithium Chloride 48-64 catenin (cadherin associated protein), beta 1 Mus musculus 22-34 27083516-6 2016 The activation of Wnt/beta-catenin signaling by lithium chloride treatment reduced the number and activity of bone marrow-derived osteoclast-like cells in vitro, suggesting that the restoration of trabecular bone in vivo was due to decreased bone resorption, consistent with the reduced receptor activator of NF-kappaB ligand/osteoprotegerin ratio in Runx2-overexpressing osteoblasts. Lithium Chloride 48-64 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 287-325 27083516-6 2016 The activation of Wnt/beta-catenin signaling by lithium chloride treatment reduced the number and activity of bone marrow-derived osteoclast-like cells in vitro, suggesting that the restoration of trabecular bone in vivo was due to decreased bone resorption, consistent with the reduced receptor activator of NF-kappaB ligand/osteoprotegerin ratio in Runx2-overexpressing osteoblasts. Lithium Chloride 48-64 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 326-341 27083516-6 2016 The activation of Wnt/beta-catenin signaling by lithium chloride treatment reduced the number and activity of bone marrow-derived osteoclast-like cells in vitro, suggesting that the restoration of trabecular bone in vivo was due to decreased bone resorption, consistent with the reduced receptor activator of NF-kappaB ligand/osteoprotegerin ratio in Runx2-overexpressing osteoblasts. Lithium Chloride 48-64 runt related transcription factor 2 Mus musculus 351-356 27083516-7 2016 Lithium chloride also increased osteoblast differentiation and activity in vitro in agreement with the increase in mineral apposition rate and osteocalcin expression detected in vivo. Lithium Chloride 0-16 bone gamma-carboxyglutamate protein 2 Mus musculus 143-154 27015552-7 2016 In addition, XAV93920 (the inhibitor of the Wnt/beta-catenin pathway) blocked and LiCl (the activator of the Wnt/beta-catenin pathway) enhanced the effect of EFEMP1 on EMT. Lithium Chloride 82-86 catenin beta 1 Homo sapiens 113-125 27015552-7 2016 In addition, XAV93920 (the inhibitor of the Wnt/beta-catenin pathway) blocked and LiCl (the activator of the Wnt/beta-catenin pathway) enhanced the effect of EFEMP1 on EMT. Lithium Chloride 82-86 EGF containing fibulin extracellular matrix protein 1 Homo sapiens 158-164 27123066-7 2016 Furthermore, apigenin inhibited beta-catenin/T-cell factor/lymphoid enhancer factor signaling activation, which was induced by LiCl in a dose-dependent manner. Lithium Chloride 127-131 catenin beta 1 Homo sapiens 32-44 26872974-4 2016 Furthermore, activation of the canonical Wnt/beta-catenin pathway in RBE4 cells via nuclear beta-catenin signaling with LiCl does not alter brain endothelialMct1mRNA but increases the amount of MCT1 transporter protein. Lithium Chloride 120-124 catenin beta 1 Rattus norvegicus 45-57 26872974-4 2016 Furthermore, activation of the canonical Wnt/beta-catenin pathway in RBE4 cells via nuclear beta-catenin signaling with LiCl does not alter brain endothelialMct1mRNA but increases the amount of MCT1 transporter protein. Lithium Chloride 120-124 catenin beta 1 Rattus norvegicus 92-104 26872974-5 2016 Plasma membrane biotinylation studies and confocal microscopic examination of mCherry-tagged MCT1 indicate that increased transporter results from reduced MCT1 trafficking from the plasma membrane via the endosomal/lysosomal pathway and is facilitated by decreased MCT1 ubiquitination following LiCl treatment. Lithium Chloride 295-299 solute carrier family 16 member 1 Rattus norvegicus 93-97 26872974-6 2016 Inhibition of the Notch pathway by the gamma-secretase inhibitorN-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycinet-butyl ester negated the up-regulation of MCT1 by LiCl, demonstrating a cross-talk between the canonical Wnt/beta-catenin and Notch pathways. Lithium Chloride 170-174 notch receptor 1 Rattus norvegicus 18-23 26872974-6 2016 Inhibition of the Notch pathway by the gamma-secretase inhibitorN-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycinet-butyl ester negated the up-regulation of MCT1 by LiCl, demonstrating a cross-talk between the canonical Wnt/beta-catenin and Notch pathways. Lithium Chloride 170-174 solute carrier family 16 member 1 Rattus norvegicus 162-166 27045591-2 2016 Increasing evidence showed that Wnt/beta-catenin pathway and the orphan nuclear receptor Nurr1 play crucial roles in the survival and functional maintenance of DA neurons in the midbrain and GSK-3beta antagonists LiCl and SB216763 were used to activate Wnt/beta-catenin pathway experimentally. Lithium Chloride 213-217 catenin beta 1 Rattus norvegicus 36-48 27045591-2 2016 Increasing evidence showed that Wnt/beta-catenin pathway and the orphan nuclear receptor Nurr1 play crucial roles in the survival and functional maintenance of DA neurons in the midbrain and GSK-3beta antagonists LiCl and SB216763 were used to activate Wnt/beta-catenin pathway experimentally. Lithium Chloride 213-217 nuclear receptor subfamily 4, group A, member 2 Rattus norvegicus 89-94 27045591-2 2016 Increasing evidence showed that Wnt/beta-catenin pathway and the orphan nuclear receptor Nurr1 play crucial roles in the survival and functional maintenance of DA neurons in the midbrain and GSK-3beta antagonists LiCl and SB216763 were used to activate Wnt/beta-catenin pathway experimentally. Lithium Chloride 213-217 glycogen synthase kinase 3 beta Rattus norvegicus 191-200 27045591-5 2016 Our data showed that PC12 cell viability was inhibited by rotenone, but attenuated by GSK-3beta antagonists LiCl or SB216763. Lithium Chloride 108-112 glycogen synthase kinase 3 beta Rattus norvegicus 86-95 27226553-5 2016 Furthermore, the mechanistic view that the proliferative function of Crlz-1 is caused by relaying Wnt/beta-catenin to pre-B cell receptor signaling pathways through the regulation of Runx/CBFbeta heterodimerization was also verified by employing niclosamide, XAV939, and LiCl as Wnt inhibitors and activator, respectively. Lithium Chloride 271-275 UTP3 small subunit processome component Homo sapiens 69-75 27471387-12 2016 Taken together, these data implicated potential roles of miR-210 in lithium chloride-pilocarpine-induced epilepsy model and miR-210 could serve as a potential therapeutic target in status epilepticus. Lithium Chloride 68-84 microRNA 210 Rattus norvegicus 57-64 26593276-5 2016 We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1). Lithium Chloride 14-30 interleukin 1 beta Homo sapiens 247-264 26593276-5 2016 We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1). Lithium Chloride 14-30 interleukin 6 Homo sapiens 266-308 26593276-5 2016 We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1). Lithium Chloride 14-30 interleukin 10 Homo sapiens 390-404 26593276-5 2016 We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1). Lithium Chloride 14-30 mannose receptor C-type 1 Homo sapiens 409-413 26593276-5 2016 We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1). Lithium Chloride 32-36 interleukin 1 beta Homo sapiens 247-264 26593276-5 2016 We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1). Lithium Chloride 32-36 interleukin 6 Homo sapiens 266-308 26593276-5 2016 We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1). Lithium Chloride 32-36 interleukin 10 Homo sapiens 390-404 26593276-5 2016 We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1). Lithium Chloride 32-36 mannose receptor C-type 1 Homo sapiens 409-413 27255637-6 2016 Lithium chloride, an activator of Wnt/beta-catenin pathway, antagonized the enhancement of linoelaidic acid on adipogenesis and up-regulated the levels of beta-catenin in ADSCs. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 38-50 27255637-6 2016 Lithium chloride, an activator of Wnt/beta-catenin pathway, antagonized the enhancement of linoelaidic acid on adipogenesis and up-regulated the levels of beta-catenin in ADSCs. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 155-167 27238574-4 2016 In the present study, the phosphorylation status of GSK3beta in the kidney cortex of rats administered lithium chloride and foscarnet, a typical inhibitor of NaPi-IIa, was examined using Western blotting. Lithium Chloride 103-119 glycogen synthase kinase 3 beta Rattus norvegicus 52-60 27082317-9 2016 The results of the present study therefore suggested that the Wnt/beta-catenin signaling pathway may be involved in CGRP- and LiCl-promoted osteoblastic differentiation of BMSCs. Lithium Chloride 126-130 catenin beta 1 Homo sapiens 66-78 26996481-12 2016 Meanwhile, LiCl decreased the activity of GSK-3beta and increased the expression of beta-catenin and partially reversed the spatial memory deficits in MWM and the apoptosis caused by CIH. Lithium Chloride 11-15 glycogen synthase kinase 3 beta Mus musculus 42-51 26996481-12 2016 Meanwhile, LiCl decreased the activity of GSK-3beta and increased the expression of beta-catenin and partially reversed the spatial memory deficits in MWM and the apoptosis caused by CIH. Lithium Chloride 11-15 catenin (cadherin associated protein), beta 1 Mus musculus 84-96 26996481-13 2016 CONCLUSIONS: Wnt/beta-catenin signaling pathway abnormalities possibly play an important role in the development of cognitive deficits among mice exposed to CIH and that LiCl might attenuate CIH-induced cognitive impairment via Wnt/beta-catenin signaling pathway. Lithium Chloride 170-174 catenin (cadherin associated protein), beta 1 Mus musculus 232-244 26935904-14 2016 Decreased VEGFR-2 caused by ROS was ameliorated by beta-TrCP siRNA, proteasome inhibitor MG132 and GSK-3beta activity inhibitor (lithium chloride and SB216763). Lithium Chloride 129-145 kinase insert domain receptor Homo sapiens 10-17 26935904-14 2016 Decreased VEGFR-2 caused by ROS was ameliorated by beta-TrCP siRNA, proteasome inhibitor MG132 and GSK-3beta activity inhibitor (lithium chloride and SB216763). Lithium Chloride 129-145 glycogen synthase kinase 3 beta Homo sapiens 99-108 27150989-4 2016 RESULTS: 20 micromol/L XAV-939 and 20 mmol/L LiCl could effectively inhibit and activate Wnt signalling pathway of HL-60 cells respectively, could significantly down- and up-regulate the expression of cyclinD1, TCF1 and c-Jun genes (P < 0.05) and proteins (P < 0.05); moreover, the number of CD10(+) HL-60 cells in these conditions was below 1%, no early apoptosis of HL-60 cells was found. Lithium Chloride 45-49 transcription factor 7 Homo sapiens 211-215 27150989-4 2016 RESULTS: 20 micromol/L XAV-939 and 20 mmol/L LiCl could effectively inhibit and activate Wnt signalling pathway of HL-60 cells respectively, could significantly down- and up-regulate the expression of cyclinD1, TCF1 and c-Jun genes (P < 0.05) and proteins (P < 0.05); moreover, the number of CD10(+) HL-60 cells in these conditions was below 1%, no early apoptosis of HL-60 cells was found. Lithium Chloride 45-49 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 220-225 27150989-4 2016 RESULTS: 20 micromol/L XAV-939 and 20 mmol/L LiCl could effectively inhibit and activate Wnt signalling pathway of HL-60 cells respectively, could significantly down- and up-regulate the expression of cyclinD1, TCF1 and c-Jun genes (P < 0.05) and proteins (P < 0.05); moreover, the number of CD10(+) HL-60 cells in these conditions was below 1%, no early apoptosis of HL-60 cells was found. Lithium Chloride 45-49 membrane metalloendopeptidase Homo sapiens 298-302 26820815-9 2016 However, the effect of AQP3 on hNPC proliferation and ECM degradation was reversed by treatment with lithium chloride, a known activator of Wnt/beta-catenin signaling. Lithium Chloride 101-117 aquaporin 3 (Gill blood group) Homo sapiens 23-27 27015268-6 2016 Furthermore, transfected PKP1-emerald green fluorescent protein was translocated from the plasma membrane to the nucleus upon stimulation with Wnt3a and LiCl, which required the PKP1 N terminus (amino acids 161 to 270). Lithium Chloride 153-157 plakophilin 1 Homo sapiens 25-29 27015268-6 2016 Furthermore, transfected PKP1-emerald green fluorescent protein was translocated from the plasma membrane to the nucleus upon stimulation with Wnt3a and LiCl, which required the PKP1 N terminus (amino acids 161 to 270). Lithium Chloride 153-157 plakophilin 1 Homo sapiens 178-182 26631736-7 2016 Lithium chloride inhibition of GSK-3beta increased nuclear beta-catenin content and normalized nuclear PPAR-gamma in Ob-MSCs. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Homo sapiens 31-40 26631736-7 2016 Lithium chloride inhibition of GSK-3beta increased nuclear beta-catenin content and normalized nuclear PPAR-gamma in Ob-MSCs. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 59-71 26631736-7 2016 Lithium chloride inhibition of GSK-3beta increased nuclear beta-catenin content and normalized nuclear PPAR-gamma in Ob-MSCs. Lithium Chloride 0-16 peroxisome proliferator activated receptor gamma Homo sapiens 103-113 26820815-9 2016 However, the effect of AQP3 on hNPC proliferation and ECM degradation was reversed by treatment with lithium chloride, a known activator of Wnt/beta-catenin signaling. Lithium Chloride 101-117 catenin beta 1 Homo sapiens 144-156 26860078-4 2016 Cells were incubated with 10 mM lithium chloride (LiCl) to activate beta-catenin signaling. Lithium Chloride 32-48 catenin beta 1 Homo sapiens 68-80 25840567-9 2016 Inhibition of GSK3beta by LiCl led to increased levels of beta-catenin, LEF-1, cyclin D1, and CXCR-4 expression. Lithium Chloride 26-30 glycogen synthase kinase 3 beta Homo sapiens 14-22 25840567-9 2016 Inhibition of GSK3beta by LiCl led to increased levels of beta-catenin, LEF-1, cyclin D1, and CXCR-4 expression. Lithium Chloride 26-30 catenin beta 1 Homo sapiens 58-70 25840567-9 2016 Inhibition of GSK3beta by LiCl led to increased levels of beta-catenin, LEF-1, cyclin D1, and CXCR-4 expression. Lithium Chloride 26-30 lymphoid enhancer binding factor 1 Homo sapiens 72-77 25840567-9 2016 Inhibition of GSK3beta by LiCl led to increased levels of beta-catenin, LEF-1, cyclin D1, and CXCR-4 expression. Lithium Chloride 26-30 cyclin D1 Homo sapiens 79-88 25840567-9 2016 Inhibition of GSK3beta by LiCl led to increased levels of beta-catenin, LEF-1, cyclin D1, and CXCR-4 expression. Lithium Chloride 26-30 C-X-C motif chemokine receptor 4 Homo sapiens 94-100 26860078-4 2016 Cells were incubated with 10 mM lithium chloride (LiCl) to activate beta-catenin signaling. Lithium Chloride 50-54 catenin beta 1 Homo sapiens 68-80 26860078-10 2016 LiCl reduced the sensitivity of A549/WT cells to cisplatin (P<0.01); and upregulated, increased phosphorylation (P<0.05) and enhanced nuclear translocation of beta-catenin. Lithium Chloride 0-4 catenin beta 1 Homo sapiens 165-177 25535091-6 2016 After the combination treatment of these two drugs (PPT + LiCl), the improved learning and memory abilities of ovariectomized rats in Morris water maze, increased dendritic spines in CA1 region, and decreased tau phosphorylation at Ser-396 in hippocampus were observed. Lithium Chloride 58-62 carbonic anhydrase 1 Rattus norvegicus 183-186 26320084-4 2016 AIMS: We investigated whether delivery of the GSK3beta inhibitor, lithium chloride (LiCl), during the recovery period from acute DSS-induced colitis in mice promoted colonic regeneration and ameliorated disease symptoms. Lithium Chloride 66-82 glycogen synthase kinase 3 beta Mus musculus 46-54 25535091-7 2016 Furthermore, PPT + LiCl treatment significantly increased ERalpha level in the nuclear fraction of hippocampus, and in the cytoplasmic fraction, the total level of GSK-3beta was declined after treatment with its increased phosphorylation at Ser-9 (inactivation form). Lithium Chloride 19-23 estrogen receptor 1 Rattus norvegicus 58-65 25535091-7 2016 Furthermore, PPT + LiCl treatment significantly increased ERalpha level in the nuclear fraction of hippocampus, and in the cytoplasmic fraction, the total level of GSK-3beta was declined after treatment with its increased phosphorylation at Ser-9 (inactivation form). Lithium Chloride 19-23 glycogen synthase kinase 3 beta Rattus norvegicus 164-173 25535091-8 2016 This study suggested that PPT + LiCl treatment could inhibit the activation of cytoplasmic GSK-3beta and promote the nuclear translocation of ERalpha, and ERalpha together with GSK-3beta maybe the targets to preserve hippocampus-dependent cognitive ability after long-term ovariectomy. Lithium Chloride 32-36 glycogen synthase kinase 3 beta Rattus norvegicus 91-100 25535091-8 2016 This study suggested that PPT + LiCl treatment could inhibit the activation of cytoplasmic GSK-3beta and promote the nuclear translocation of ERalpha, and ERalpha together with GSK-3beta maybe the targets to preserve hippocampus-dependent cognitive ability after long-term ovariectomy. Lithium Chloride 32-36 estrogen receptor 1 Rattus norvegicus 142-149 25535091-8 2016 This study suggested that PPT + LiCl treatment could inhibit the activation of cytoplasmic GSK-3beta and promote the nuclear translocation of ERalpha, and ERalpha together with GSK-3beta maybe the targets to preserve hippocampus-dependent cognitive ability after long-term ovariectomy. Lithium Chloride 32-36 estrogen receptor 1 Rattus norvegicus 155-162 25535091-8 2016 This study suggested that PPT + LiCl treatment could inhibit the activation of cytoplasmic GSK-3beta and promote the nuclear translocation of ERalpha, and ERalpha together with GSK-3beta maybe the targets to preserve hippocampus-dependent cognitive ability after long-term ovariectomy. Lithium Chloride 32-36 glycogen synthase kinase 3 beta Rattus norvegicus 177-186 25575682-6 2016 GSK3beta emerged as a molecular link between the two pathways, evident from reduction in phospho-tau as well as BACE upon treating GSK3beta inhibitor, lithium chloride. Lithium Chloride 151-167 glycogen synthase kinase 3 alpha Rattus norvegicus 0-8 25575682-6 2016 GSK3beta emerged as a molecular link between the two pathways, evident from reduction in phospho-tau as well as BACE upon treating GSK3beta inhibitor, lithium chloride. Lithium Chloride 151-167 beta-secretase 1 Rattus norvegicus 112-116 25575682-6 2016 GSK3beta emerged as a molecular link between the two pathways, evident from reduction in phospho-tau as well as BACE upon treating GSK3beta inhibitor, lithium chloride. Lithium Chloride 151-167 glycogen synthase kinase 3 alpha Rattus norvegicus 131-139 26838164-6 2016 In this study, GSK-3beta siRNA and inhibitors (SB216763 and LiCl) were used to inhibit GSK-3beta in vitro and in vivo. Lithium Chloride 60-64 glycogen synthase kinase 3 beta Rattus norvegicus 15-24 26838164-6 2016 In this study, GSK-3beta siRNA and inhibitors (SB216763 and LiCl) were used to inhibit GSK-3beta in vitro and in vivo. Lithium Chloride 60-64 glycogen synthase kinase 3 beta Rattus norvegicus 87-96 26541329-9 2016 Finally, we demonstrated that inhibition of MAGL reduced VIC Fos immunoreactivity in response to LiCl treatment. Lithium Chloride 97-101 monoglyceride lipase Rattus norvegicus 44-48 26541329-9 2016 Finally, we demonstrated that inhibition of MAGL reduced VIC Fos immunoreactivity in response to LiCl treatment. Lithium Chloride 97-101 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 61-64 26926171-13 2016 Inhibition of GSK3beta by LiCl suppressed cyclin D1 phosphorylation and downregulation by MRB. Lithium Chloride 26-30 glycogen synthase kinase 3 beta Homo sapiens 14-22 26926171-13 2016 Inhibition of GSK3beta by LiCl suppressed cyclin D1 phosphorylation and downregulation by MRB. Lithium Chloride 26-30 cyclin D1 Homo sapiens 42-51 26320084-4 2016 AIMS: We investigated whether delivery of the GSK3beta inhibitor, lithium chloride (LiCl), during the recovery period from acute DSS-induced colitis in mice promoted colonic regeneration and ameliorated disease symptoms. Lithium Chloride 84-88 glycogen synthase kinase 3 beta Mus musculus 46-54 26483261-1 2016 In this study, the participation of glycogen synthase kinase-3beta (GSK-3beta) in the lipid deposition was investigated in the liver of large yellow croaker (Larmichthys crocea) by LiCl treatment. Lithium Chloride 181-185 glycogen synthase kinase-3 beta Larimichthys crocea 36-66 26483261-1 2016 In this study, the participation of glycogen synthase kinase-3beta (GSK-3beta) in the lipid deposition was investigated in the liver of large yellow croaker (Larmichthys crocea) by LiCl treatment. Lithium Chloride 181-185 glycogen synthase kinase-3 beta Larimichthys crocea 68-77 26483261-3 2016 Furthermore, the gene expression and activity of fatty acid synthetase (FAS) and lipoprotein lipase (LPL) in the liver was inhibited by LiCl treatment. Lithium Chloride 136-140 lipoprotein lipase Larimichthys crocea 81-99 26483261-3 2016 Furthermore, the gene expression and activity of fatty acid synthetase (FAS) and lipoprotein lipase (LPL) in the liver was inhibited by LiCl treatment. Lithium Chloride 136-140 lipoprotein lipase Larimichthys crocea 101-104 26499268-4 2016 Here we report that LiCl (50 mM) inhibits Hedgehog signaling in bovine articular chondrocytes such that the induction of GLI1 and PTCH1 expression is reduced by 71 and 55%, respectively. Lithium Chloride 20-24 GLI family zinc finger 1 Bos taurus 121-125 26499268-4 2016 Here we report that LiCl (50 mM) inhibits Hedgehog signaling in bovine articular chondrocytes such that the induction of GLI1 and PTCH1 expression is reduced by 71 and 55%, respectively. Lithium Chloride 20-24 patched 1 Bos taurus 130-135 26785133-12 2016 In contrast to SB216763, LiCl markedly elevated Mfn2 and COX IV protein expression levels when given together with insulin. Lithium Chloride 25-29 mitofusin 2 Mus musculus 48-52 26211731-0 2016 The Aversive Agent Lithium Chloride Suppresses Phasic Dopamine Release Through Central GLP-1 Receptors. Lithium Chloride 19-35 glucagon Rattus norvegicus 87-92 26211731-5 2016 As some behavioral effects of LiCl appear to be mediated through glucagon-like peptide-1 receptor (GLP-1R) activation, we hypothesized that the suppression of phasic dopamine by LiCl is GLP-1R dependent. Lithium Chloride 30-34 glucagon-like peptide 1 receptor Rattus norvegicus 99-105 26211731-5 2016 As some behavioral effects of LiCl appear to be mediated through glucagon-like peptide-1 receptor (GLP-1R) activation, we hypothesized that the suppression of phasic dopamine by LiCl is GLP-1R dependent. Lithium Chloride 30-34 glucagon-like peptide 1 receptor Rattus norvegicus 186-192 26211731-5 2016 As some behavioral effects of LiCl appear to be mediated through glucagon-like peptide-1 receptor (GLP-1R) activation, we hypothesized that the suppression of phasic dopamine by LiCl is GLP-1R dependent. Lithium Chloride 178-182 glucagon-like peptide 1 receptor Rattus norvegicus 99-105 26211731-5 2016 As some behavioral effects of LiCl appear to be mediated through glucagon-like peptide-1 receptor (GLP-1R) activation, we hypothesized that the suppression of phasic dopamine by LiCl is GLP-1R dependent. Lithium Chloride 178-182 glucagon-like peptide 1 receptor Rattus norvegicus 186-192 26211731-6 2016 Indeed, peripheral pretreatment with the GLP-1R antagonist exendin-9 (Ex-9) potently attenuated the LiCl-induced suppression of dopamine. Lithium Chloride 100-104 glucagon-like peptide 1 receptor Rattus norvegicus 41-47 26211731-7 2016 Pretreatment with Ex-9 did not, however, affect the suppression of phasic dopamine release by the kappa-opioid receptor agonist, salvinorin A, supporting a selective effect of GLP-1R stimulation in LiCl-induced dopamine suppression. Lithium Chloride 198-202 glucagon-like peptide 1 receptor Rattus norvegicus 176-182 26414021-5 2016 The Wnt activator WAY-262611 and beta-catenin activator lithium chloride (LiCl) were used to activate the pathway at distinct levels in HSCs. Lithium Chloride 56-72 catenin beta 1 Rattus norvegicus 33-45 26414021-5 2016 The Wnt activator WAY-262611 and beta-catenin activator lithium chloride (LiCl) were used to activate the pathway at distinct levels in HSCs. Lithium Chloride 74-78 catenin beta 1 Rattus norvegicus 33-45 26785133-12 2016 In contrast to SB216763, LiCl markedly elevated Mfn2 and COX IV protein expression levels when given together with insulin. Lithium Chloride 25-29 cytochrome c oxidase subunit 4I1 Mus musculus 57-63 27685772-7 2016 Edaravone and lithium chloride treatments were found to reduce the increase in SOD and CAT activity following ketamine administration in a non-significant manner but caused no change in TBARS levels. Lithium Chloride 14-30 catalase Rattus norvegicus 87-90 26433146-5 2016 In the present work, we administrated BDNF in a concentration capable of inducing in vivo neocortical LTP, into the IC immediately after CTA acquisition in two different conditions: a "strong-CTA" induced by 0.2M lithium chloride i.p. Lithium Chloride 213-229 brain derived neurotrophic factor Homo sapiens 38-42 26599428-3 2016 A similar half-sandwich type complex, [{P(6-Me-2-py)3}FeCl(OTf)] 2THF (6 2THF), is obtained from reaction of 2 with Fe(OTf)2 in the presence of LiCl, only now with all three of the N-atoms of the ligand coordinated to Fe(II). Lithium Chloride 144-148 POU class 2 homeobox 2 Homo sapiens 119-124 26651340-7 2016 For example, reducing extracellular calcium or treating cells with lithium chloride (LiCl) blocks the induction of trisomy 21 by Abeta. Lithium Chloride 67-83 amyloid beta (A4) precursor protein Mus musculus 129-134 26651340-7 2016 For example, reducing extracellular calcium or treating cells with lithium chloride (LiCl) blocks the induction of trisomy 21 by Abeta. Lithium Chloride 85-89 amyloid beta (A4) precursor protein Mus musculus 129-134 26335930-8 2015 AML12 cells treated by Wnt3a or the glycogen synthase kinase 3beta inhibitor LiCl exposed to H-R demonstrated decreased reactive oxygen species and reduced apoptosis compared to controls. Lithium Chloride 77-81 glycogen synthase kinase 3 beta Mus musculus 36-66 26606859-10 2016 Pretreatment of INS-1 with LiCl inhibited dexamethasone induced ROS generation and INS-1 apoptosis. Lithium Chloride 27-31 insulin 1 Rattus norvegicus 16-21 26515369-8 2015 Subsequently, GC treated with lithium chloride (LiCl), a pharmacological activator of AKT, provided a response consistent with IGF-I treated cells, as LiCl, FSH, and FSH plus LiCl increased CTNNB1 accumulation compared with non-treated controls (P <= 0.03; n=3). Lithium Chloride 30-46 AKT serine/threonine kinase 1 Bos taurus 86-89 26515369-8 2015 Subsequently, GC treated with lithium chloride (LiCl), a pharmacological activator of AKT, provided a response consistent with IGF-I treated cells, as LiCl, FSH, and FSH plus LiCl increased CTNNB1 accumulation compared with non-treated controls (P <= 0.03; n=3). Lithium Chloride 30-46 insulin like growth factor 1 Bos taurus 127-132 26515369-8 2015 Subsequently, GC treated with lithium chloride (LiCl), a pharmacological activator of AKT, provided a response consistent with IGF-I treated cells, as LiCl, FSH, and FSH plus LiCl increased CTNNB1 accumulation compared with non-treated controls (P <= 0.03; n=3). Lithium Chloride 30-46 catenin beta 1 Bos taurus 190-196 26515369-8 2015 Subsequently, GC treated with lithium chloride (LiCl), a pharmacological activator of AKT, provided a response consistent with IGF-I treated cells, as LiCl, FSH, and FSH plus LiCl increased CTNNB1 accumulation compared with non-treated controls (P <= 0.03; n=3). Lithium Chloride 48-52 AKT serine/threonine kinase 1 Bos taurus 86-89 26515369-8 2015 Subsequently, GC treated with lithium chloride (LiCl), a pharmacological activator of AKT, provided a response consistent with IGF-I treated cells, as LiCl, FSH, and FSH plus LiCl increased CTNNB1 accumulation compared with non-treated controls (P <= 0.03; n=3). Lithium Chloride 48-52 insulin like growth factor 1 Bos taurus 127-132 26515369-8 2015 Subsequently, GC treated with lithium chloride (LiCl), a pharmacological activator of AKT, provided a response consistent with IGF-I treated cells, as LiCl, FSH, and FSH plus LiCl increased CTNNB1 accumulation compared with non-treated controls (P <= 0.03; n=3). Lithium Chloride 48-52 catenin beta 1 Bos taurus 190-196 26385428-5 2015 We show that inhibition of GSK3beta with lithium chloride enhances Gli3 processing into its repressor form, consequently downregulating Hh-Gli signaling, reducing cell proliferation and inducing cell death. Lithium Chloride 41-57 glycogen synthase kinase 3 beta Homo sapiens 27-35 26385428-5 2015 We show that inhibition of GSK3beta with lithium chloride enhances Gli3 processing into its repressor form, consequently downregulating Hh-Gli signaling, reducing cell proliferation and inducing cell death. Lithium Chloride 41-57 GLI family zinc finger 3 Homo sapiens 67-71 26385428-5 2015 We show that inhibition of GSK3beta with lithium chloride enhances Gli3 processing into its repressor form, consequently downregulating Hh-Gli signaling, reducing cell proliferation and inducing cell death. Lithium Chloride 41-57 GLI family zinc finger 1 Homo sapiens 67-70 26385428-6 2015 Analysis of the molecular mechanisms revealed that lithium chloride enhances Gli3-SuFu-GSK3beta complex formation leading to more efficient Gli3 cleavage and Hh-Gli signaling downregulation. Lithium Chloride 51-67 GLI family zinc finger 3 Homo sapiens 77-81 26385428-6 2015 Analysis of the molecular mechanisms revealed that lithium chloride enhances Gli3-SuFu-GSK3beta complex formation leading to more efficient Gli3 cleavage and Hh-Gli signaling downregulation. Lithium Chloride 51-67 SUFU negative regulator of hedgehog signaling Homo sapiens 82-86 26385428-6 2015 Analysis of the molecular mechanisms revealed that lithium chloride enhances Gli3-SuFu-GSK3beta complex formation leading to more efficient Gli3 cleavage and Hh-Gli signaling downregulation. Lithium Chloride 51-67 glycogen synthase kinase 3 beta Homo sapiens 87-95 26385428-6 2015 Analysis of the molecular mechanisms revealed that lithium chloride enhances Gli3-SuFu-GSK3beta complex formation leading to more efficient Gli3 cleavage and Hh-Gli signaling downregulation. Lithium Chloride 51-67 GLI family zinc finger 3 Homo sapiens 140-144 26385428-6 2015 Analysis of the molecular mechanisms revealed that lithium chloride enhances Gli3-SuFu-GSK3beta complex formation leading to more efficient Gli3 cleavage and Hh-Gli signaling downregulation. Lithium Chloride 51-67 GLI family zinc finger 1 Homo sapiens 77-80 26347944-4 2015 However, treatment with an inhibitor of GSK3beta, lithium chloride, significantly increased the production of IL-10 and IL-12 compared with the untreated control and significantly decreased the production of IL-10 and IL-12 compared with LPS stimulation. Lithium Chloride 50-66 glycogen synthase kinase 3 beta Sus scrofa 40-48 26347944-4 2015 However, treatment with an inhibitor of GSK3beta, lithium chloride, significantly increased the production of IL-10 and IL-12 compared with the untreated control and significantly decreased the production of IL-10 and IL-12 compared with LPS stimulation. Lithium Chloride 50-66 IL10 Sus scrofa 110-115 26347944-4 2015 However, treatment with an inhibitor of GSK3beta, lithium chloride, significantly increased the production of IL-10 and IL-12 compared with the untreated control and significantly decreased the production of IL-10 and IL-12 compared with LPS stimulation. Lithium Chloride 50-66 IL12 Sus scrofa 120-125 26347944-4 2015 However, treatment with an inhibitor of GSK3beta, lithium chloride, significantly increased the production of IL-10 and IL-12 compared with the untreated control and significantly decreased the production of IL-10 and IL-12 compared with LPS stimulation. Lithium Chloride 50-66 IL10 Sus scrofa 208-213 26347944-4 2015 However, treatment with an inhibitor of GSK3beta, lithium chloride, significantly increased the production of IL-10 and IL-12 compared with the untreated control and significantly decreased the production of IL-10 and IL-12 compared with LPS stimulation. Lithium Chloride 50-66 IL12 Sus scrofa 218-223 26108692-0 2015 Lithium chloride antileukemic activity in acute promyelocytic leukemia is GSK-3 and MEK/ERK dependent. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Mus musculus 74-79 26108692-0 2015 Lithium chloride antileukemic activity in acute promyelocytic leukemia is GSK-3 and MEK/ERK dependent. Lithium Chloride 0-16 midkine Mus musculus 84-87 26108692-0 2015 Lithium chloride antileukemic activity in acute promyelocytic leukemia is GSK-3 and MEK/ERK dependent. Lithium Chloride 0-16 mitogen-activated protein kinase 1 Mus musculus 88-91 26108692-2 2015 To target the MEK/ERK pathway, we identified glycogen synthase kinase-3beta (GSK-3beta) inhibitors including lithium chloride (LiCl) as activators of this pathway in APL cells. Lithium Chloride 109-125 midkine Mus musculus 14-17 26108692-2 2015 To target the MEK/ERK pathway, we identified glycogen synthase kinase-3beta (GSK-3beta) inhibitors including lithium chloride (LiCl) as activators of this pathway in APL cells. Lithium Chloride 109-125 mitogen-activated protein kinase 1 Mus musculus 18-21 26108692-2 2015 To target the MEK/ERK pathway, we identified glycogen synthase kinase-3beta (GSK-3beta) inhibitors including lithium chloride (LiCl) as activators of this pathway in APL cells. Lithium Chloride 127-131 midkine Mus musculus 14-17 26108692-2 2015 To target the MEK/ERK pathway, we identified glycogen synthase kinase-3beta (GSK-3beta) inhibitors including lithium chloride (LiCl) as activators of this pathway in APL cells. Lithium Chloride 127-131 mitogen-activated protein kinase 1 Mus musculus 18-21 26108692-7 2015 In this work, we demonstrate that LiCl, a well-tolerated agent in humans, has antileukemic activity in APL and that it has the potential to restore RA-induced transcriptional activation and differentiation in RA-resistant APL cells in an MEK/ERK-dependent manner. Lithium Chloride 34-38 midkine Mus musculus 238-241 26108692-7 2015 In this work, we demonstrate that LiCl, a well-tolerated agent in humans, has antileukemic activity in APL and that it has the potential to restore RA-induced transcriptional activation and differentiation in RA-resistant APL cells in an MEK/ERK-dependent manner. Lithium Chloride 34-38 mitogen-activated protein kinase 1 Mus musculus 242-245 26674355-5 2015 Lithium chloride (LiCl) and short interfering RNA (siRNA)-mediated inhibition of GSK-3beta significantly enhanced the ability of hyperoside to protect L02 liver cells from H2O2-induced oxidative damage, leading to increased cell survival shown by the maintenance of cell membrane integrity and elevated levels of glutathione (GSH), one of the endogenous antioxidant biomarkers. Lithium Chloride 18-22 glycogen synthase kinase 3 beta Homo sapiens 81-90 26524411-1 2015 Intraperitoneal injections (ip) of lithium chloride at large doses induce c-Fos expression in the brain regions implicated in conditioned taste aversion (CTA) learning, and also activate the hypothalamic-pituitary-adrenal (HPA) axis and increase the plasma corticosterone levels in rats. Lithium Chloride 35-51 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 74-79 26069270-4 2015 Glycogen synthase kinase 3beta activity was interfered with glycogen synthase kinase 3beta inhibitor lithium chloride or transduced with replication defective adenovirus vector expressing catalytically inactive glycogen synthase kinase 3beta (GSK3beta-KM). Lithium Chloride 101-117 glycogen synthase kinase 3 beta Mus musculus 0-30 26456500-9 2015 LY294002 (an inhibitor of GSK3beta phosphorylation) and LiCl (an inhibitor of GSK3beta activity) diminished and potentiated increase of IL-10 levels by DGA, respectively. Lithium Chloride 56-60 glycogen synthase kinase 3 beta Mus musculus 78-86 26456500-9 2015 LY294002 (an inhibitor of GSK3beta phosphorylation) and LiCl (an inhibitor of GSK3beta activity) diminished and potentiated increase of IL-10 levels by DGA, respectively. Lithium Chloride 56-60 interleukin 10 Mus musculus 136-141 26054493-2 2015 Our previous study shows that lithium chloride (LiCl) optimizes skeletal myoblast (SkM) for transplantation by mimicking the Wnt/beta-catenin signaling activities. Lithium Chloride 30-46 Wnt family member 1 Rattus norvegicus 125-128 26054493-2 2015 Our previous study shows that lithium chloride (LiCl) optimizes skeletal myoblast (SkM) for transplantation by mimicking the Wnt/beta-catenin signaling activities. Lithium Chloride 30-46 catenin beta 1 Rattus norvegicus 129-141 26054493-2 2015 Our previous study shows that lithium chloride (LiCl) optimizes skeletal myoblast (SkM) for transplantation by mimicking the Wnt/beta-catenin signaling activities. Lithium Chloride 48-52 Wnt family member 1 Rattus norvegicus 125-128 26054493-2 2015 Our previous study shows that lithium chloride (LiCl) optimizes skeletal myoblast (SkM) for transplantation by mimicking the Wnt/beta-catenin signaling activities. Lithium Chloride 48-52 catenin beta 1 Rattus norvegicus 129-141 26560046-8 2015 Meanwhile, LiCl increased GSK3beta transcript levels and the proliferation of CaSki cells in a HPV16-dependent manner. Lithium Chloride 11-15 glycogen synthase kinase 3 beta Homo sapiens 26-34 26618897-9 2015 Moreover, LiCl boosted 8-oxo-dG staining, expression of IKKalpha and MMP-10. Lithium Chloride 10-14 component of inhibitor of nuclear factor kappa B kinase complex Homo sapiens 56-64 26618897-9 2015 Moreover, LiCl boosted 8-oxo-dG staining, expression of IKKalpha and MMP-10. Lithium Chloride 10-14 matrix metallopeptidase 10 Homo sapiens 69-75 26608648-8 2015 In addition, the co-localization of LC3 and mitochondria and the preservation of mitochondrial function within LiCl-treated cells were observed, confirming that the damaged mitochondria were cleared through autophagy (mitophagy). Lithium Chloride 111-115 microtubule associated protein 1 light chain 3 alpha Homo sapiens 36-39 26598603-6 2016 PLIN2 siRNA reduces inhibitory GSK3 levels and lithium chloride (LiCl)-upregulated beta-catenin or CCAAT/enhancer binding protein alpha (c/EBPalpha) expression. Lithium Chloride 47-63 perilipin 2 Homo sapiens 0-5 26598603-6 2016 PLIN2 siRNA reduces inhibitory GSK3 levels and lithium chloride (LiCl)-upregulated beta-catenin or CCAAT/enhancer binding protein alpha (c/EBPalpha) expression. Lithium Chloride 47-63 catenin beta 1 Homo sapiens 83-95 26598603-6 2016 PLIN2 siRNA reduces inhibitory GSK3 levels and lithium chloride (LiCl)-upregulated beta-catenin or CCAAT/enhancer binding protein alpha (c/EBPalpha) expression. Lithium Chloride 47-63 CCAAT enhancer binding protein alpha Homo sapiens 99-135 26598603-6 2016 PLIN2 siRNA reduces inhibitory GSK3 levels and lithium chloride (LiCl)-upregulated beta-catenin or CCAAT/enhancer binding protein alpha (c/EBPalpha) expression. Lithium Chloride 47-63 CCAAT enhancer binding protein alpha Homo sapiens 137-147 26598603-6 2016 PLIN2 siRNA reduces inhibitory GSK3 levels and lithium chloride (LiCl)-upregulated beta-catenin or CCAAT/enhancer binding protein alpha (c/EBPalpha) expression. Lithium Chloride 65-69 perilipin 2 Homo sapiens 0-5 26598603-6 2016 PLIN2 siRNA reduces inhibitory GSK3 levels and lithium chloride (LiCl)-upregulated beta-catenin or CCAAT/enhancer binding protein alpha (c/EBPalpha) expression. Lithium Chloride 65-69 catenin beta 1 Homo sapiens 83-95 26598603-6 2016 PLIN2 siRNA reduces inhibitory GSK3 levels and lithium chloride (LiCl)-upregulated beta-catenin or CCAAT/enhancer binding protein alpha (c/EBPalpha) expression. Lithium Chloride 65-69 CCAAT enhancer binding protein alpha Homo sapiens 99-135 26598603-6 2016 PLIN2 siRNA reduces inhibitory GSK3 levels and lithium chloride (LiCl)-upregulated beta-catenin or CCAAT/enhancer binding protein alpha (c/EBPalpha) expression. Lithium Chloride 65-69 CCAAT enhancer binding protein alpha Homo sapiens 137-147 26598603-7 2016 OA treatment decreases LiCl-increased c/EBPalpha via PLIN2-c/EBPalpha dissociation. Lithium Chloride 23-27 CCAAT enhancer binding protein alpha Homo sapiens 38-48 26598603-7 2016 OA treatment decreases LiCl-increased c/EBPalpha via PLIN2-c/EBPalpha dissociation. Lithium Chloride 23-27 perilipin 2 Homo sapiens 53-58 26598603-7 2016 OA treatment decreases LiCl-increased c/EBPalpha via PLIN2-c/EBPalpha dissociation. Lithium Chloride 23-27 CCAAT enhancer binding protein alpha Homo sapiens 59-69 26275858-3 2015 The aim of this study was to determine whether lithium chloride (LiCl), a selective inhibitor of glycogen synthetase kinase 3 beta (GSK-3beta), mitigates wear debris-induced osteolysis in a murine calvarial model of osteolysis. Lithium Chloride 47-63 glycogen synthase kinase 3 beta Mus musculus 132-141 26275858-3 2015 The aim of this study was to determine whether lithium chloride (LiCl), a selective inhibitor of glycogen synthetase kinase 3 beta (GSK-3beta), mitigates wear debris-induced osteolysis in a murine calvarial model of osteolysis. Lithium Chloride 65-69 glycogen synthase kinase 3 beta Mus musculus 132-141 26275858-6 2015 The LiCl treatment significantly inhibited GSK-3beta activity and increased beta-catenin and axin-2 expression in a dose-dependent manner, dramatically mitigating the Ti particle-induced suppression of osteoblast numbers and the expression of bone formation markers. Lithium Chloride 4-8 glycogen synthase kinase 3 beta Mus musculus 43-52 26275858-6 2015 The LiCl treatment significantly inhibited GSK-3beta activity and increased beta-catenin and axin-2 expression in a dose-dependent manner, dramatically mitigating the Ti particle-induced suppression of osteoblast numbers and the expression of bone formation markers. Lithium Chloride 4-8 catenin (cadherin associated protein), beta 1 Mus musculus 76-88 26275858-6 2015 The LiCl treatment significantly inhibited GSK-3beta activity and increased beta-catenin and axin-2 expression in a dose-dependent manner, dramatically mitigating the Ti particle-induced suppression of osteoblast numbers and the expression of bone formation markers. Lithium Chloride 4-8 axin 2 Mus musculus 93-99 26275858-9 2015 This suggests that selective inhibitors of GSK-3beta such as LiCl may help prevent and treat wear debris-induced osteolysis. Lithium Chloride 61-65 glycogen synthase kinase 3 beta Mus musculus 43-52 26018040-9 2015 Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3. Lithium Chloride 72-88 catenin beta 1 Rattus norvegicus 38-50 26018040-9 2015 Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3. Lithium Chloride 72-88 glycogen synthase kinase 3 beta Rattus norvegicus 132-141 26018040-9 2015 Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3. Lithium Chloride 72-88 catenin beta 1 Rattus norvegicus 146-158 26018040-9 2015 Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3. Lithium Chloride 72-88 solute carrier family 4 member 1 (Diego blood group) Rattus norvegicus 186-189 26018040-9 2015 Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3. Lithium Chloride 72-88 solute carrier family 4 member 3 Rattus norvegicus 190-193 26018040-9 2015 Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3. Lithium Chloride 90-94 catenin beta 1 Rattus norvegicus 38-50 26018040-9 2015 Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3. Lithium Chloride 90-94 glycogen synthase kinase 3 beta Rattus norvegicus 132-141 26018040-9 2015 Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3. Lithium Chloride 90-94 catenin beta 1 Rattus norvegicus 146-158 26018040-9 2015 Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3. Lithium Chloride 90-94 solute carrier family 4 member 1 (Diego blood group) Rattus norvegicus 186-189 26018040-9 2015 Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3. Lithium Chloride 90-94 solute carrier family 4 member 3 Rattus norvegicus 190-193 26069102-4 2015 We used lithium chloride (LiCl) to inhibit cytosol beta-catenin phosphorylation and degradation to increase nuclear beta-catenin levels in BC cells. Lithium Chloride 8-24 catenin beta 1 Homo sapiens 51-63 26239426-4 2015 We have shown that LiCl increases beta-catenin level, induces its translocation to the nucleus and consequently up-regulates beta-catenin/Tcf-dependent transcription in NT2/D1 cells. Lithium Chloride 19-23 catenin beta 1 Homo sapiens 34-46 26239426-4 2015 We have shown that LiCl increases beta-catenin level, induces its translocation to the nucleus and consequently up-regulates beta-catenin/Tcf-dependent transcription in NT2/D1 cells. Lithium Chloride 19-23 catenin beta 1 Homo sapiens 125-137 26239426-4 2015 We have shown that LiCl increases beta-catenin level, induces its translocation to the nucleus and consequently up-regulates beta-catenin/Tcf-dependent transcription in NT2/D1 cells. Lithium Chloride 19-23 hepatocyte nuclear factor 4 alpha Homo sapiens 138-141 26239426-5 2015 Our results also suggest that LiCl treatment leads to increased expression of SOX2 and SOX3 proteins in NT2/D1 cells through activation of canonical Wnt signaling. Lithium Chloride 30-34 SRY-box transcription factor 2 Homo sapiens 78-82 26239426-5 2015 Our results also suggest that LiCl treatment leads to increased expression of SOX2 and SOX3 proteins in NT2/D1 cells through activation of canonical Wnt signaling. Lithium Chloride 30-34 SRY-box transcription factor 3 Homo sapiens 87-91 26352537-0 2015 Lithium chloride attenuates the abnormal osteogenic/adipogenic differentiation of bone marrow-derived mesenchymal stem cells obtained from rats with steroid-related osteonecrosis by activating the beta-catenin pathway. Lithium Chloride 0-16 catenin beta 1 Rattus norvegicus 197-209 26352537-5 2015 LiCl significantly increased the expression of osteocalcin and Runx2 in the ONFH-BMMSCs during osteogenic induction. Lithium Chloride 0-4 bone gamma-carboxyglutamate protein Rattus norvegicus 47-58 26352537-5 2015 LiCl significantly increased the expression of osteocalcin and Runx2 in the ONFH-BMMSCs during osteogenic induction. Lithium Chloride 0-4 RUNX family transcription factor 2 Rattus norvegicus 63-68 26352537-7 2015 Furthermore, LiCl exerted anti-adipogenic effects on the ONFH-BMMSCs by inhibiting the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and fatty acid binding protein 4 (Fabp4) during adipogenic induction, and decreasing lipid droplet formation at the end of adipogenic induction. Lithium Chloride 13-17 peroxisome proliferator-activated receptor gamma Rattus norvegicus 101-149 26352537-7 2015 Furthermore, LiCl exerted anti-adipogenic effects on the ONFH-BMMSCs by inhibiting the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and fatty acid binding protein 4 (Fabp4) during adipogenic induction, and decreasing lipid droplet formation at the end of adipogenic induction. Lithium Chloride 13-17 peroxisome proliferator-activated receptor gamma Rattus norvegicus 151-160 26352537-7 2015 Furthermore, LiCl exerted anti-adipogenic effects on the ONFH-BMMSCs by inhibiting the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and fatty acid binding protein 4 (Fabp4) during adipogenic induction, and decreasing lipid droplet formation at the end of adipogenic induction. Lithium Chloride 13-17 fatty acid binding protein 4 Rattus norvegicus 166-194 26352537-7 2015 Furthermore, LiCl exerted anti-adipogenic effects on the ONFH-BMMSCs by inhibiting the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and fatty acid binding protein 4 (Fabp4) during adipogenic induction, and decreasing lipid droplet formation at the end of adipogenic induction. Lithium Chloride 13-17 fatty acid binding protein 4 Rattus norvegicus 196-201 26352537-8 2015 These effects of LiCl on the ONFH-BMMSCs were associated with an increased expression of beta-catenin and a decreased expression of phosphorylated GSK-3beta at Tyr-216, and these effects were abolished by treatment with quercetin, an antagonist of the beta-catenin pathway. Lithium Chloride 17-21 catenin beta 1 Rattus norvegicus 89-101 26352537-8 2015 These effects of LiCl on the ONFH-BMMSCs were associated with an increased expression of beta-catenin and a decreased expression of phosphorylated GSK-3beta at Tyr-216, and these effects were abolished by treatment with quercetin, an antagonist of the beta-catenin pathway. Lithium Chloride 17-21 glycogen synthase kinase 3 beta Rattus norvegicus 147-156 26352537-8 2015 These effects of LiCl on the ONFH-BMMSCs were associated with an increased expression of beta-catenin and a decreased expression of phosphorylated GSK-3beta at Tyr-216, and these effects were abolished by treatment with quercetin, an antagonist of the beta-catenin pathway. Lithium Chloride 17-21 catenin beta 1 Rattus norvegicus 252-264 26352537-10 2015 However, as demonstrated by our findings, LiCl reduces abnormal adipogenic activity and simultaneously increases the osteogenic differentiation of ONFH-BMMSCs by activating the beta-catenin pathway. Lithium Chloride 42-46 catenin beta 1 Rattus norvegicus 177-189 26069102-4 2015 We used lithium chloride (LiCl) to inhibit cytosol beta-catenin phosphorylation and degradation to increase nuclear beta-catenin levels in BC cells. Lithium Chloride 8-24 catenin beta 1 Homo sapiens 116-128 26069102-4 2015 We used lithium chloride (LiCl) to inhibit cytosol beta-catenin phosphorylation and degradation to increase nuclear beta-catenin levels in BC cells. Lithium Chloride 26-30 catenin beta 1 Homo sapiens 51-63 26069102-4 2015 We used lithium chloride (LiCl) to inhibit cytosol beta-catenin phosphorylation and degradation to increase nuclear beta-catenin levels in BC cells. Lithium Chloride 26-30 catenin beta 1 Homo sapiens 116-128 26069102-10 2015 LiCl significantly increased nuclear beta-catenin, resulting in MMP9 activation in BC cells. Lithium Chloride 0-4 catenin beta 1 Homo sapiens 37-49 26069102-10 2015 LiCl significantly increased nuclear beta-catenin, resulting in MMP9 activation in BC cells. Lithium Chloride 0-4 matrix metallopeptidase 9 Homo sapiens 64-68 26236947-8 2015 Moreover, AMPK-induced GSK3beta and SIRT1 activities were found to be responsible for inhibiting c-Myc-mediated upregulation of MTDH, as LiCl (an inhibitor of GSK3beta) and EX-527 (an inhibitor of SIRT1) reversed AICAR-mediated downregulation of c-Myc and MTDH expressions. Lithium Chloride 137-141 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 10-14 26220974-6 2015 Although blocking GSK3beta activity did not alter axon growth under physiological conditions in vivo, blocking it using a dominant-negative mutant or lithium chloride prevented mTORC1-induced accelerated axon growth. Lithium Chloride 150-166 CREB regulated transcription coactivator 1 Mus musculus 177-183 27227074-8 2015 LiCl(-)induced hypothermia was completely prevented by ondansetron (2mg/kg, i.p., a 5-HT3 receptor antagonist that reduces cancer chemotherapy-induced nausea and vomiting), but was insensitive to promethazine (10 mg/kg, i.p., a predominantly histamine-H1 and muscarinic receptor antagonist that is commonly used to treat motion sickness). Lithium Chloride 0-4 5-hydroxytryptamine receptor 3A Rattus norvegicus 84-98 26236947-8 2015 Moreover, AMPK-induced GSK3beta and SIRT1 activities were found to be responsible for inhibiting c-Myc-mediated upregulation of MTDH, as LiCl (an inhibitor of GSK3beta) and EX-527 (an inhibitor of SIRT1) reversed AICAR-mediated downregulation of c-Myc and MTDH expressions. Lithium Chloride 137-141 glycogen synthase kinase 3 beta Homo sapiens 23-31 26236947-8 2015 Moreover, AMPK-induced GSK3beta and SIRT1 activities were found to be responsible for inhibiting c-Myc-mediated upregulation of MTDH, as LiCl (an inhibitor of GSK3beta) and EX-527 (an inhibitor of SIRT1) reversed AICAR-mediated downregulation of c-Myc and MTDH expressions. Lithium Chloride 137-141 sirtuin 1 Homo sapiens 36-41 26236947-8 2015 Moreover, AMPK-induced GSK3beta and SIRT1 activities were found to be responsible for inhibiting c-Myc-mediated upregulation of MTDH, as LiCl (an inhibitor of GSK3beta) and EX-527 (an inhibitor of SIRT1) reversed AICAR-mediated downregulation of c-Myc and MTDH expressions. Lithium Chloride 137-141 MYC proto-oncogene, bHLH transcription factor Homo sapiens 97-102 26236947-8 2015 Moreover, AMPK-induced GSK3beta and SIRT1 activities were found to be responsible for inhibiting c-Myc-mediated upregulation of MTDH, as LiCl (an inhibitor of GSK3beta) and EX-527 (an inhibitor of SIRT1) reversed AICAR-mediated downregulation of c-Myc and MTDH expressions. Lithium Chloride 137-141 metadherin Homo sapiens 128-132 26236947-8 2015 Moreover, AMPK-induced GSK3beta and SIRT1 activities were found to be responsible for inhibiting c-Myc-mediated upregulation of MTDH, as LiCl (an inhibitor of GSK3beta) and EX-527 (an inhibitor of SIRT1) reversed AICAR-mediated downregulation of c-Myc and MTDH expressions. Lithium Chloride 137-141 glycogen synthase kinase 3 beta Homo sapiens 159-167 26271413-8 2015 Moreover, by the of engagement of Wnt pathway agonist (LiCl) and antagonist (ICG 001) we demonstrate that DOX-TRF conjugate effectively reduces transcription of key genes involved in beta-catenin signaling transduction trial (Wnt3a, DVL-1, FZD-3, LRP5, beta-catenin, DKK2) and triggers morphology alternations of CML cells. Lithium Chloride 55-59 Wnt family member 3A Homo sapiens 34-37 26174175-0 2015 Lithium chloride prevents interleukin-1beta induced cartilage degradation and loss of mechanical properties. Lithium Chloride 0-16 interleukin 1 beta Bos taurus 26-43 26174175-9 2015 In an inflammatory model of cartilage destruction, lithium chloride blocked interleukin-1beta signaling in the form of nitric oxide and prostaglandin E2 release and prevented matrix catabolism such that the loss of mechanical integrity observed with interleukin-1beta alone was inhibited. Lithium Chloride 51-67 interleukin 1 beta Bos taurus 76-93 26174175-9 2015 In an inflammatory model of cartilage destruction, lithium chloride blocked interleukin-1beta signaling in the form of nitric oxide and prostaglandin E2 release and prevented matrix catabolism such that the loss of mechanical integrity observed with interleukin-1beta alone was inhibited. Lithium Chloride 51-67 interleukin 1 beta Bos taurus 250-267 26271413-8 2015 Moreover, by the of engagement of Wnt pathway agonist (LiCl) and antagonist (ICG 001) we demonstrate that DOX-TRF conjugate effectively reduces transcription of key genes involved in beta-catenin signaling transduction trial (Wnt3a, DVL-1, FZD-3, LRP5, beta-catenin, DKK2) and triggers morphology alternations of CML cells. Lithium Chloride 55-59 catenin beta 1 Homo sapiens 183-195 26983211-5 2015 According to the results of the PP II hemolysis experiment in vitro, the anion hypertonic solution LiCl, NaHCO3, Na2SO4 and PBS significantly inhibited the hemolysis induced by PP II (P < 0.05), while blockers NPPB and DIDS remarkably promoted it (P < 0.01). Lithium Chloride 99-103 natriuretic peptide B Homo sapiens 213-217 26197224-11 2015 This protective effect was partially blocked by the inhibitors lithium chloride treatment in HT22, indicating the involvement of Akt/GSK-3beta inactivation during the neuroprotective effect of ATX. Lithium Chloride 63-79 thymoma viral proto-oncogene 1 Mus musculus 129-132 26197224-11 2015 This protective effect was partially blocked by the inhibitors lithium chloride treatment in HT22, indicating the involvement of Akt/GSK-3beta inactivation during the neuroprotective effect of ATX. Lithium Chloride 63-79 glycogen synthase kinase 3 beta Mus musculus 133-142 26003276-4 2015 Intraperitoenal injection of lithium chloride (0.15M, 3ml/kg or 12ml/kg) at night induced CTA formation and the HPA axis activation and increased c-Fos expression in both the parabrachial nucleus (PBN) and the nucleus tractus of solitarius (NTS) in a dose dependent manner. Lithium Chloride 29-45 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 146-151 26101106-2 2015 We investigated the expression pattern and cellular distribution of Pum2 in patients with drug-refractory temporal lobe epilepsy (TLE) and rats with lithium chloride-pilocarpine-induced epilepsy. Lithium Chloride 149-165 pumilio RNA binding family member 2 Homo sapiens 68-72 26151480-11 2015 Lithium chloride (LiCl, 5 mM), a GSK3beta inhibitor, treatment alone did not increase the apoptosis of B16 cells, while pretreatment with LiCl markedly reversed AT-I-induced apoptosis. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Mus musculus 33-41 26151480-11 2015 Lithium chloride (LiCl, 5 mM), a GSK3beta inhibitor, treatment alone did not increase the apoptosis of B16 cells, while pretreatment with LiCl markedly reversed AT-I-induced apoptosis. Lithium Chloride 18-22 glycogen synthase kinase 3 beta Mus musculus 33-41 26516309-0 2015 Lithium Chloride Promotes Apoptosis in Human Leukemia NB4 Cells by Inhibiting Glycogen Synthase Kinase-3 Beta. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Homo sapiens 78-109 26516309-7 2015 Moreover, LiCl significantly increased the level of Ser9-phosphorylated glycogen synthase kinase 3beta(p-GSK-3beta), and decreased the level of Akt1 protein in a dose-dependent manner. Lithium Chloride 10-14 glycogen synthase kinase 3 beta Homo sapiens 105-114 26516309-7 2015 Moreover, LiCl significantly increased the level of Ser9-phosphorylated glycogen synthase kinase 3beta(p-GSK-3beta), and decreased the level of Akt1 protein in a dose-dependent manner. Lithium Chloride 10-14 AKT serine/threonine kinase 1 Homo sapiens 144-148 26378915-7 2015 Four weeks of treatment with LiCl at 0.5% in food pellets decreased GFAP protein and transcripts in several brain regions, although with mild side effects and some mortality. Lithium Chloride 29-33 glial fibrillary acidic protein Mus musculus 68-72 26031381-0 2015 Lithium chloride administration prevents spatial learning and memory impairment in repeated cerebral ischemia-reperfusion mice by depressing apoptosis and increasing BDNF expression in hippocampus. Lithium Chloride 0-16 brain derived neurotrophic factor Mus musculus 166-170 26031381-6 2015 2 mmol/kg LiCl evidently reversed the morphologic changes, up-regulated the survival neuron count and increased the BDNF gene and protein expression. Lithium Chloride 10-14 brain derived neurotrophic factor Mus musculus 116-120 26247931-6 2015 Furthermore, treatment with LiCl, an activator of Wnt/beta-catenin signaling, rescued the reduction in C2C12 differentiation caused by BAMBI siRNA. Lithium Chloride 28-32 catenin (cadherin associated protein), beta 1 Mus musculus 54-66 26266541-11 2015 Other experiments suggested that the differential effects of sodium butyrate and lithium chloride might be explained by their effects on TNFalpha production. Lithium Chloride 81-97 tumor necrosis factor Macaca mulatta 137-145 26247931-6 2015 Furthermore, treatment with LiCl, an activator of Wnt/beta-catenin signaling, rescued the reduction in C2C12 differentiation caused by BAMBI siRNA. Lithium Chloride 28-32 BMP and activin membrane-bound inhibitor Mus musculus 135-140 25985152-5 2015 We showed that Kruppel-like transcription factor 4 (Klf4) regulates the choice of differentiation pathway of these cells through beta-catenin activation and was itself regulated by the canonical Wnt pathway activator lithium chloride. Lithium Chloride 217-233 Kruppel-like factor 4 (gut) Mus musculus 15-50 26252009-9 2015 The changes in beta-catenin levels in response to embelin were blocked by lithium chloride, a GSK-3 inhibitor, indicating that embelin may decrease beta-catenin expression via GSK-3beta activation. Lithium Chloride 74-90 catenin beta 1 Homo sapiens 15-27 26252009-9 2015 The changes in beta-catenin levels in response to embelin were blocked by lithium chloride, a GSK-3 inhibitor, indicating that embelin may decrease beta-catenin expression via GSK-3beta activation. Lithium Chloride 74-90 catenin beta 1 Homo sapiens 148-160 26252009-9 2015 The changes in beta-catenin levels in response to embelin were blocked by lithium chloride, a GSK-3 inhibitor, indicating that embelin may decrease beta-catenin expression via GSK-3beta activation. Lithium Chloride 74-90 glycogen synthase kinase 3 beta Homo sapiens 176-185 25985152-5 2015 We showed that Kruppel-like transcription factor 4 (Klf4) regulates the choice of differentiation pathway of these cells through beta-catenin activation and was itself regulated by the canonical Wnt pathway activator lithium chloride. Lithium Chloride 217-233 Kruppel-like factor 4 (gut) Mus musculus 52-56 25912432-9 2015 Furthermore, application with GSK-3beta inhibitor lithium chloride (LiCl) reversed TPEN-induced downregulation of beta-catenin and impairment of cell proliferation. Lithium Chloride 50-66 glycogen synthase kinase 3 beta Mus musculus 30-39 25892295-9 2015 It was revealed that aquaporin (AQP)-5 and T1alpha were expressed in BMSCs, and induction with LiCl or Sal B increased the expression of AQP-5 and T1alpha. Lithium Chloride 95-99 aquaporin 5 Homo sapiens 137-142 25892295-9 2015 It was revealed that aquaporin (AQP)-5 and T1alpha were expressed in BMSCs, and induction with LiCl or Sal B increased the expression of AQP-5 and T1alpha. Lithium Chloride 95-99 podoplanin Homo sapiens 147-154 25533726-9 2015 Furthermore, administration of lithium chloride (100 mg/kg, intraperitoneally) 30 min before the contextual fear conditioning reversed the inhibitory effect of 0.8 % sevoflurane on SEFL as well as phosphorylated (p)-Akt, p-GSK-3beta and BDNF expressions. Lithium Chloride 31-47 AKT serine/threonine kinase 1 Rattus norvegicus 216-219 25533726-9 2015 Furthermore, administration of lithium chloride (100 mg/kg, intraperitoneally) 30 min before the contextual fear conditioning reversed the inhibitory effect of 0.8 % sevoflurane on SEFL as well as phosphorylated (p)-Akt, p-GSK-3beta and BDNF expressions. Lithium Chloride 31-47 glycogen synthase kinase 3 beta Rattus norvegicus 223-232 25533726-9 2015 Furthermore, administration of lithium chloride (100 mg/kg, intraperitoneally) 30 min before the contextual fear conditioning reversed the inhibitory effect of 0.8 % sevoflurane on SEFL as well as phosphorylated (p)-Akt, p-GSK-3beta and BDNF expressions. Lithium Chloride 31-47 brain-derived neurotrophic factor Rattus norvegicus 237-241 25912432-9 2015 Furthermore, application with GSK-3beta inhibitor lithium chloride (LiCl) reversed TPEN-induced downregulation of beta-catenin and impairment of cell proliferation. Lithium Chloride 50-66 catenin (cadherin associated protein), beta 1 Mus musculus 114-126 25912432-9 2015 Furthermore, application with GSK-3beta inhibitor lithium chloride (LiCl) reversed TPEN-induced downregulation of beta-catenin and impairment of cell proliferation. Lithium Chloride 68-72 glycogen synthase kinase 3 beta Mus musculus 30-39 25912432-9 2015 Furthermore, application with GSK-3beta inhibitor lithium chloride (LiCl) reversed TPEN-induced downregulation of beta-catenin and impairment of cell proliferation. Lithium Chloride 68-72 catenin (cadherin associated protein), beta 1 Mus musculus 114-126 25838072-8 2015 Moreover, DHT decreased the levels of total and nuclear beta-catenin, an important regulator of hair growth and proliferation, while lithium chloride, a glycogen synthase kinase-3beta inhibitor, attenuated the DHT-induced downregulation of the beta-catenin level. Lithium Chloride 133-149 glycogen synthase kinase 3 beta Rattus norvegicus 153-183 26200352-7 2015 Inhibition of GSK3alpha and GSK3beta with LiCl or SB216763 induced an increase in IL-12p40 mRNA and protein. Lithium Chloride 42-46 glycogen synthase kinase 3 alpha Bos taurus 14-23 26200352-7 2015 Inhibition of GSK3alpha and GSK3beta with LiCl or SB216763 induced an increase in IL-12p40 mRNA and protein. Lithium Chloride 42-46 glycogen synthase kinase 3 beta Bos taurus 28-36 26200352-7 2015 Inhibition of GSK3alpha and GSK3beta with LiCl or SB216763 induced an increase in IL-12p40 mRNA and protein. Lithium Chloride 42-46 interleukin 12B Bos taurus 82-90 26087957-10 2015 Furthermore, the effect of MK-2206 on Mcl-1 downregulation was abolished by GSK3beta inhibitor, lithium chloride and proteasome inhibitor, MG-132, suggesting that MK-2206 acted through a GSK3beta-mediated, proteasome-dependent protein degradation. Lithium Chloride 96-112 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 38-43 26087957-10 2015 Furthermore, the effect of MK-2206 on Mcl-1 downregulation was abolished by GSK3beta inhibitor, lithium chloride and proteasome inhibitor, MG-132, suggesting that MK-2206 acted through a GSK3beta-mediated, proteasome-dependent protein degradation. Lithium Chloride 96-112 glycogen synthase kinase 3 beta Homo sapiens 187-195 25838072-8 2015 Moreover, DHT decreased the levels of total and nuclear beta-catenin, an important regulator of hair growth and proliferation, while lithium chloride, a glycogen synthase kinase-3beta inhibitor, attenuated the DHT-induced downregulation of the beta-catenin level. Lithium Chloride 133-149 catenin beta 1 Rattus norvegicus 244-256 25869100-8 2015 Our results reveal that capsaicin treatment suppressed LiCl or SB415286-mediated activation of beta-catenin signaling. Lithium Chloride 55-59 catenin beta 1 Homo sapiens 95-107 25724107-7 2015 The salutary effects of SFN on high-glucose-stimulated RMC were abolished by overexpression of GSK3beta while being rescued by lithium chloride, a well-known GSK3beta inhibitor. Lithium Chloride 127-143 glycogen synthase kinase 3 beta Rattus norvegicus 158-166 25738332-10 2015 Following differentiation with the glycogen synthase kinase 3beta (GSK3beta) inhibitor LiCl, the cells began to express E-cadherin and, at once, Twist1 and Snail expression was strongly downregulated, suggesting a MET-reverting process. Lithium Chloride 87-91 glycogen synthase kinase 3 beta Homo sapiens 35-65 25746333-9 2015 We also found that lower viral replication after LiCl treatment was associated with the reduced mRNA levels of pro-inflammatory IL-8, IL-6, IL-1 beta, tumor necrosis factor alpha and decreased NF-kappaB nuclear translocation. Lithium Chloride 49-53 C-X-C motif chemokine ligand 8 Homo sapiens 128-132 25746333-9 2015 We also found that lower viral replication after LiCl treatment was associated with the reduced mRNA levels of pro-inflammatory IL-8, IL-6, IL-1 beta, tumor necrosis factor alpha and decreased NF-kappaB nuclear translocation. Lithium Chloride 49-53 interleukin 6 Homo sapiens 134-138 25746333-9 2015 We also found that lower viral replication after LiCl treatment was associated with the reduced mRNA levels of pro-inflammatory IL-8, IL-6, IL-1 beta, tumor necrosis factor alpha and decreased NF-kappaB nuclear translocation. Lithium Chloride 49-53 interleukin 1 beta Homo sapiens 140-149 25746333-9 2015 We also found that lower viral replication after LiCl treatment was associated with the reduced mRNA levels of pro-inflammatory IL-8, IL-6, IL-1 beta, tumor necrosis factor alpha and decreased NF-kappaB nuclear translocation. Lithium Chloride 49-53 tumor necrosis factor Homo sapiens 151-178 25738332-10 2015 Following differentiation with the glycogen synthase kinase 3beta (GSK3beta) inhibitor LiCl, the cells began to express E-cadherin and, at once, Twist1 and Snail expression was strongly downregulated, suggesting a MET-reverting process. Lithium Chloride 87-91 glycogen synthase kinase 3 beta Homo sapiens 67-75 25738332-10 2015 Following differentiation with the glycogen synthase kinase 3beta (GSK3beta) inhibitor LiCl, the cells began to express E-cadherin and, at once, Twist1 and Snail expression was strongly downregulated, suggesting a MET-reverting process. Lithium Chloride 87-91 cadherin 1 Homo sapiens 120-130 25738332-10 2015 Following differentiation with the glycogen synthase kinase 3beta (GSK3beta) inhibitor LiCl, the cells began to express E-cadherin and, at once, Twist1 and Snail expression was strongly downregulated, suggesting a MET-reverting process. Lithium Chloride 87-91 twist family bHLH transcription factor 1 Homo sapiens 145-151 25738332-10 2015 Following differentiation with the glycogen synthase kinase 3beta (GSK3beta) inhibitor LiCl, the cells began to express E-cadherin and, at once, Twist1 and Snail expression was strongly downregulated, suggesting a MET-reverting process. Lithium Chloride 87-91 snail family transcriptional repressor 1 Homo sapiens 156-161 25738332-13 2015 Our observation indicates that LiCl, a GSK3beta inhibitor, induces MET in vitro, suggesting that LiCl and GSK3beta could represent, respectively, interesting drug, and target for CRC therapy. Lithium Chloride 31-35 glycogen synthase kinase 3 beta Homo sapiens 39-47 25738332-13 2015 Our observation indicates that LiCl, a GSK3beta inhibitor, induces MET in vitro, suggesting that LiCl and GSK3beta could represent, respectively, interesting drug, and target for CRC therapy. Lithium Chloride 31-35 glycogen synthase kinase 3 beta Homo sapiens 106-114 25870166-0 2015 The iNOS/Src/FAK axis contributes to lithium chloride-mediated macrophage migration. Lithium Chloride 37-53 nitric oxide synthase 2, inducible Mus musculus 4-8 25870166-7 2015 Consistent with Src and migration increment was iNOS-dependent in macrophages, markedly reduced Src expression, activity and cell migration were observed in iNOS-null PEMs treated with LiCl. Lithium Chloride 185-189 Rous sarcoma oncogene Mus musculus 16-19 25870166-0 2015 The iNOS/Src/FAK axis contributes to lithium chloride-mediated macrophage migration. Lithium Chloride 37-53 Rous sarcoma oncogene Mus musculus 9-12 25870166-7 2015 Consistent with Src and migration increment was iNOS-dependent in macrophages, markedly reduced Src expression, activity and cell migration were observed in iNOS-null PEMs treated with LiCl. Lithium Chloride 185-189 nitric oxide synthase 2, inducible Mus musculus 48-52 25870166-7 2015 Consistent with Src and migration increment was iNOS-dependent in macrophages, markedly reduced Src expression, activity and cell migration were observed in iNOS-null PEMs treated with LiCl. Lithium Chloride 185-189 Rous sarcoma oncogene Mus musculus 96-99 25870166-0 2015 The iNOS/Src/FAK axis contributes to lithium chloride-mediated macrophage migration. Lithium Chloride 37-53 PTK2 protein tyrosine kinase 2 Mus musculus 13-16 25870166-7 2015 Consistent with Src and migration increment was iNOS-dependent in macrophages, markedly reduced Src expression, activity and cell migration were observed in iNOS-null PEMs treated with LiCl. Lithium Chloride 185-189 nitric oxide synthase 2, inducible Mus musculus 157-161 25870166-4 2015 The inhibition of LiCl-induced macrophage migration by PP2 (an inhibitor for Src family kinases (SFKs)) suggested the involvement of SFKs in this process. Lithium Chloride 18-22 neuropeptide Y receptor Y6 Mus musculus 55-58 25870166-8 2015 Moreover, FAK knockdown suppressed LiCl-stimulated macrophage motility, suggesting the involvement of FAK in this process. Lithium Chloride 35-39 PTK2 protein tyrosine kinase 2 Mus musculus 10-13 25870166-8 2015 Moreover, FAK knockdown suppressed LiCl-stimulated macrophage motility, suggesting the involvement of FAK in this process. Lithium Chloride 35-39 PTK2 protein tyrosine kinase 2 Mus musculus 102-105 25870166-4 2015 The inhibition of LiCl-induced macrophage migration by PP2 (an inhibitor for Src family kinases (SFKs)) suggested the involvement of SFKs in this process. Lithium Chloride 18-22 Rous sarcoma oncogene Mus musculus 77-80 25810523-7 2015 We also report, for the first time, the beneficial effects of lithium chloride, a reversible inhibitor of the glycogen synthase kinase-3, that rescued NMJ defects in MuSKDeltaCRD mice and therefore constitutes a novel therapeutic reagent for the treatment of neuromuscular disorders linked to Wnt-MuSK signaling pathway deficiency. Lithium Chloride 62-78 muscle, skeletal, receptor tyrosine kinase Mus musculus 166-170 25368097-7 2015 Lithium chloride-induced Wnt signaling activation downstream of the PEDF interaction site attenuated the inhibitory effect of PEDF on EPCs and rescued the wound-healing deficiency in diabetic mice. Lithium Chloride 0-16 serine (or cysteine) peptidase inhibitor, clade F, member 1 Mus musculus 68-72 25368097-7 2015 Lithium chloride-induced Wnt signaling activation downstream of the PEDF interaction site attenuated the inhibitory effect of PEDF on EPCs and rescued the wound-healing deficiency in diabetic mice. Lithium Chloride 0-16 serine (or cysteine) peptidase inhibitor, clade F, member 1 Mus musculus 126-130 25678534-6 2015 Glra2 knockout mice demonstrate reduced ethanol intake and preference in the 24-hour two-bottle choice test and increased initial aversive responses to ethanol and lithium chloride. Lithium Chloride 164-180 glycine receptor, alpha 2 subunit Mus musculus 0-5 25555252-13 2015 CONCLUSION: Our findings show that LiCl-mediated GSK3beta inhibition prevents palatal fusion and osteogenic differentiation in palatal shelves by increased beta-catenin signaling. Lithium Chloride 35-39 glycogen synthase kinase 3 beta Mus musculus 49-57 25608967-9 2015 When treated with LiCl, an isoform nonselective inhibitor of GSK3 and known inducer of polyuria, WT mice developed significant polyuria within 6 days. Lithium Chloride 18-22 glycogen synthase kinase 3 beta Mus musculus 61-65 25608967-11 2015 This study demonstrates, for the first time, that GSK3alpha could play a crucial role in renal urine concentration and suggest that GSK3alpha might be one of the initial targets of Li(+) in LiCl-induced nephrogenic diabetes insipidus. Lithium Chloride 190-194 glycogen synthase kinase 3 alpha Mus musculus 50-59 25608967-11 2015 This study demonstrates, for the first time, that GSK3alpha could play a crucial role in renal urine concentration and suggest that GSK3alpha might be one of the initial targets of Li(+) in LiCl-induced nephrogenic diabetes insipidus. Lithium Chloride 190-194 glycogen synthase kinase 3 alpha Mus musculus 132-141 25788675-3 2015 Previously, we identified calcitonin gene-related peptide (CGRP)-expressing neurons in the external lateral subdivision of the PBN (PBel) as being sufficient to suppress appetite and necessary for the anorexigenic effects of appetite-suppressing substances including lithium chloride (LiCl), a compound often used to induce CTA. Lithium Chloride 267-283 calcitonin/calcitonin-related polypeptide, alpha Mus musculus 26-57 25788675-3 2015 Previously, we identified calcitonin gene-related peptide (CGRP)-expressing neurons in the external lateral subdivision of the PBN (PBel) as being sufficient to suppress appetite and necessary for the anorexigenic effects of appetite-suppressing substances including lithium chloride (LiCl), a compound often used to induce CTA. Lithium Chloride 267-283 calcitonin/calcitonin-related polypeptide, alpha Mus musculus 59-63 25788675-3 2015 Previously, we identified calcitonin gene-related peptide (CGRP)-expressing neurons in the external lateral subdivision of the PBN (PBel) as being sufficient to suppress appetite and necessary for the anorexigenic effects of appetite-suppressing substances including lithium chloride (LiCl), a compound often used to induce CTA. Lithium Chloride 285-289 calcitonin/calcitonin-related polypeptide, alpha Mus musculus 26-57 25788675-3 2015 Previously, we identified calcitonin gene-related peptide (CGRP)-expressing neurons in the external lateral subdivision of the PBN (PBel) as being sufficient to suppress appetite and necessary for the anorexigenic effects of appetite-suppressing substances including lithium chloride (LiCl), a compound often used to induce CTA. Lithium Chloride 285-289 calcitonin/calcitonin-related polypeptide, alpha Mus musculus 59-63 25555252-13 2015 CONCLUSION: Our findings show that LiCl-mediated GSK3beta inhibition prevents palatal fusion and osteogenic differentiation in palatal shelves by increased beta-catenin signaling. Lithium Chloride 35-39 catenin (cadherin associated protein), beta 1 Mus musculus 156-168 25547373-2 2015 Lithium chloride (LiCl) and valproate (VPA), two well-known mood stabilizers, have been reported to act through GSK-3beta and HDAC inhibition, respectively. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Rattus norvegicus 112-121 24760594-6 2015 We found that LiCl mobilizes the alpha-tubulin N-acetyltransferase 1 (alphaTAT1) in the signaling pathway mediating GSK-3beta and adenylate cyclase III. Lithium Chloride 14-18 alpha tubulin acetyltransferase 1 Homo sapiens 33-68 24760594-6 2015 We found that LiCl mobilizes the alpha-tubulin N-acetyltransferase 1 (alphaTAT1) in the signaling pathway mediating GSK-3beta and adenylate cyclase III. Lithium Chloride 14-18 alpha tubulin acetyltransferase 1 Homo sapiens 70-79 24760594-6 2015 We found that LiCl mobilizes the alpha-tubulin N-acetyltransferase 1 (alphaTAT1) in the signaling pathway mediating GSK-3beta and adenylate cyclase III. Lithium Chloride 14-18 glycogen synthase kinase 3 beta Homo sapiens 116-125 24760594-7 2015 In conclusion, our results suggested that LiCl treatments activate alphaTAT1 by the inhibition of GSK-3beta and promote the alpha-tubulin acetylation, and then elongate the primary cilia. Lithium Chloride 42-46 alpha tubulin acetyltransferase 1 Homo sapiens 67-76 24760594-7 2015 In conclusion, our results suggested that LiCl treatments activate alphaTAT1 by the inhibition of GSK-3beta and promote the alpha-tubulin acetylation, and then elongate the primary cilia. Lithium Chloride 42-46 glycogen synthase kinase 3 beta Homo sapiens 98-107 25547373-2 2015 Lithium chloride (LiCl) and valproate (VPA), two well-known mood stabilizers, have been reported to act through GSK-3beta and HDAC inhibition, respectively. Lithium Chloride 18-22 glycogen synthase kinase 3 beta Rattus norvegicus 112-121 25192664-10 2015 Meanwhile, LiCl further up-regulated phospho-Akt Ser473 and phospho-GSK3beta Ser9 expression. Lithium Chloride 11-15 thymoma viral proto-oncogene 1 Mus musculus 45-48 25714610-8 2015 In contrast, the expression of adipogenic proteins (PPARgamma, C/EBPalpha, and acetyl CoA carboxylase) were decreased significantly with LiCl (by 1.6, 2.6, and 1.9-fold respectively) and BIO (by 7, 17, and 5.6-fold respectively) treatments. Lithium Chloride 137-141 peroxisome proliferator activated receptor gamma Homo sapiens 52-61 25714610-8 2015 In contrast, the expression of adipogenic proteins (PPARgamma, C/EBPalpha, and acetyl CoA carboxylase) were decreased significantly with LiCl (by 1.6, 2.6, and 1.9-fold respectively) and BIO (by 7, 17, and 5.6-fold respectively) treatments. Lithium Chloride 137-141 CCAAT enhancer binding protein alpha Homo sapiens 63-73 25645196-5 2015 FINDINGS: Here we show that beta-catenin stabilization by the glycogen synthase kinase 3 inhibitor lithium chloride (LiCl) reduced growth of primary hedgehog-driven MB tumor spheres from patched heterozygous mice (Ptch(+/-)) in vitro. Lithium Chloride 99-115 catenin (cadherin associated protein), beta 1 Mus musculus 28-40 25645196-5 2015 FINDINGS: Here we show that beta-catenin stabilization by the glycogen synthase kinase 3 inhibitor lithium chloride (LiCl) reduced growth of primary hedgehog-driven MB tumor spheres from patched heterozygous mice (Ptch(+/-)) in vitro. Lithium Chloride 117-121 catenin (cadherin associated protein), beta 1 Mus musculus 28-40 25053111-0 2015 Lithium chloride suppresses LPS-mediated matrix metalloproteinase-9 expression in macrophages through phosphorylation of GSK-3beta. Lithium Chloride 0-16 matrix metallopeptidase 9 Mus musculus 41-67 25053111-0 2015 Lithium chloride suppresses LPS-mediated matrix metalloproteinase-9 expression in macrophages through phosphorylation of GSK-3beta. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Mus musculus 121-130 25053111-2 2015 We report that lithium chloride (LiCl) or CHIR99021, inhibitors of Wnt signaling pathway, enhance phosphorylation of glycogen synthase kinase-3beta and suppress lipopolysaccharide-mediated upregulation of MMP-9 expression in murine macrophage RAW264.7 cells in a dose-dependent manner. Lithium Chloride 15-31 glycogen synthase kinase 3 beta Mus musculus 117-147 25053111-2 2015 We report that lithium chloride (LiCl) or CHIR99021, inhibitors of Wnt signaling pathway, enhance phosphorylation of glycogen synthase kinase-3beta and suppress lipopolysaccharide-mediated upregulation of MMP-9 expression in murine macrophage RAW264.7 cells in a dose-dependent manner. Lithium Chloride 15-31 matrix metallopeptidase 9 Mus musculus 205-210 25053111-2 2015 We report that lithium chloride (LiCl) or CHIR99021, inhibitors of Wnt signaling pathway, enhance phosphorylation of glycogen synthase kinase-3beta and suppress lipopolysaccharide-mediated upregulation of MMP-9 expression in murine macrophage RAW264.7 cells in a dose-dependent manner. Lithium Chloride 33-37 glycogen synthase kinase 3 beta Mus musculus 117-147 25053111-2 2015 We report that lithium chloride (LiCl) or CHIR99021, inhibitors of Wnt signaling pathway, enhance phosphorylation of glycogen synthase kinase-3beta and suppress lipopolysaccharide-mediated upregulation of MMP-9 expression in murine macrophage RAW264.7 cells in a dose-dependent manner. Lithium Chloride 33-37 matrix metallopeptidase 9 Mus musculus 205-210 25053111-4 2015 Beneficial effects on atherosclerosis or cerebral ischemia in animal studies caused by LiCl may be in part explained by the suppression of MMP-9 gene expression. Lithium Chloride 87-91 matrix metallopeptidase 9 Mus musculus 139-144 25301276-8 2015 The specificity of these changes is supported by the antagonism exerted by a catalytically inactive form of the kinase and through inhibitors of GSK3beta such as lithium chloride and TDZD-8. Lithium Chloride 162-178 glycogen synthase kinase 3 beta L homeolog Xenopus laevis 145-153 25565601-4 2015 In this study, we showed that glycogen synthase kinase 3beta (GSK3beta) inhibitors - SB216763, LiCl and azakenpaullone - enhanced LPS-induced OPN expression in mouse peritoneal macrophages. Lithium Chloride 95-99 glycogen synthase kinase 3 beta Mus musculus 30-60 25565601-4 2015 In this study, we showed that glycogen synthase kinase 3beta (GSK3beta) inhibitors - SB216763, LiCl and azakenpaullone - enhanced LPS-induced OPN expression in mouse peritoneal macrophages. Lithium Chloride 95-99 glycogen synthase kinase 3 beta Mus musculus 62-70 25565601-4 2015 In this study, we showed that glycogen synthase kinase 3beta (GSK3beta) inhibitors - SB216763, LiCl and azakenpaullone - enhanced LPS-induced OPN expression in mouse peritoneal macrophages. Lithium Chloride 95-99 secreted phosphoprotein 1 Mus musculus 142-145 25192664-10 2015 Meanwhile, LiCl further up-regulated phospho-Akt Ser473 and phospho-GSK3beta Ser9 expression. Lithium Chloride 11-15 glycogen synthase kinase 3 beta Mus musculus 68-76 25192664-14 2015 LiCl treatment exerted a neuroprotective effect on learning and memory by potentiating the Akt/GSK3beta cell-signaling pathway. Lithium Chloride 0-4 thymoma viral proto-oncogene 1 Mus musculus 91-94 25192664-14 2015 LiCl treatment exerted a neuroprotective effect on learning and memory by potentiating the Akt/GSK3beta cell-signaling pathway. Lithium Chloride 0-4 glycogen synthase kinase 3 beta Mus musculus 95-103 25451297-2 2015 In this study, we investigated the role of Lithium Chloride (LiCl), a drug largely used for the treatment of neurological disorders, on the two major central myelin gene expression (PLP and MBP) in mouse oligodendrocytes. Lithium Chloride 43-59 proteolipid protein (myelin) 1 Mus musculus 182-185 25451297-2 2015 In this study, we investigated the role of Lithium Chloride (LiCl), a drug largely used for the treatment of neurological disorders, on the two major central myelin gene expression (PLP and MBP) in mouse oligodendrocytes. Lithium Chloride 43-59 myelin basic protein Mus musculus 190-193 25451297-0 2015 Lithium chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/beta-catenin and Akt/CREB pathways. Lithium Chloride 0-16 proteolipid protein (myelin) 1 Mus musculus 28-31 25451297-0 2015 Lithium chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/beta-catenin and Akt/CREB pathways. Lithium Chloride 0-16 myelin basic protein Mus musculus 36-39 25451297-2 2015 In this study, we investigated the role of Lithium Chloride (LiCl), a drug largely used for the treatment of neurological disorders, on the two major central myelin gene expression (PLP and MBP) in mouse oligodendrocytes. Lithium Chloride 61-65 proteolipid protein (myelin) 1 Mus musculus 182-185 25451297-0 2015 Lithium chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/beta-catenin and Akt/CREB pathways. Lithium Chloride 0-16 catenin (cadherin associated protein), beta 1 Mus musculus 79-91 25451297-2 2015 In this study, we investigated the role of Lithium Chloride (LiCl), a drug largely used for the treatment of neurological disorders, on the two major central myelin gene expression (PLP and MBP) in mouse oligodendrocytes. Lithium Chloride 61-65 myelin basic protein Mus musculus 190-193 25451297-0 2015 Lithium chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/beta-catenin and Akt/CREB pathways. Lithium Chloride 0-16 thymoma viral proto-oncogene 1 Mus musculus 96-99 25451297-0 2015 Lithium chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/beta-catenin and Akt/CREB pathways. Lithium Chloride 0-16 cAMP responsive element binding protein 1 Mus musculus 100-104 25451297-3 2015 We show that LiCl enhances the expression of both PLP and MBP, by increasing mRNA amount and promoter activities. Lithium Chloride 13-17 proteolipid protein (myelin) 1 Mus musculus 50-53 25451297-3 2015 We show that LiCl enhances the expression of both PLP and MBP, by increasing mRNA amount and promoter activities. Lithium Chloride 13-17 myelin basic protein Mus musculus 58-61 25451297-9 2015 Therefore, the use of LiCl to balance between beta-catenin and CREB effectors could be considered as an efficient remyelinating strategy. Lithium Chloride 22-26 catenin (cadherin associated protein), beta 1 Mus musculus 46-58 25451297-9 2015 Therefore, the use of LiCl to balance between beta-catenin and CREB effectors could be considered as an efficient remyelinating strategy. Lithium Chloride 22-26 cAMP responsive element binding protein 1 Mus musculus 63-67 25877788-8 2015 The limit of detection for serotonin in LiCl on a radius 21 nm nanopipet electrode was 77 muM, for acetylcholine on a radius 7 nm nanopipet electrode was 205 muM, and for tryptamine on a radius 19 nm nanopipet electrode was 86 muM. Lithium Chloride 40-44 latexin Homo sapiens 91-94 25584796-6 2015 Wnt signaling is decreased in ERG-deficient endothelial cells; activation of Wnt signaling with lithium chloride, which stabilizes beta-catenin levels, corrects vascular defects in Erg(cEC-KO) embryos. Lithium Chloride 96-112 catenin (cadherin associated protein), beta 1 Mus musculus 131-143 25584796-6 2015 Wnt signaling is decreased in ERG-deficient endothelial cells; activation of Wnt signaling with lithium chloride, which stabilizes beta-catenin levels, corrects vascular defects in Erg(cEC-KO) embryos. Lithium Chloride 96-112 ETS transcription factor Mus musculus 181-191 25785037-3 2015 Here we measured p-LIMK1 protein expression in thirty temporal neocortex tissue samples from intractable TLE patients, fifteen histologically normal temporal neocortex tissue samples from trauma patients without epilepsy, in the hippocampi of lithium chloride/pilocarpine-induced TLE rats, and in controls. Lithium Chloride 243-259 LIM domain kinase 1 Homo sapiens 19-24 25876813-1 2015 OBJECTIVE: To observe the expressions of Nav1.2 and Nav1.6 in the hippocampal CA3 region of lithium chloride-pilocarpine epileptic rats to explore their potential roles in epileptogenesis. Lithium Chloride 92-108 sodium voltage-gated channel alpha subunit 2 Rattus norvegicus 41-47 25876813-1 2015 OBJECTIVE: To observe the expressions of Nav1.2 and Nav1.6 in the hippocampal CA3 region of lithium chloride-pilocarpine epileptic rats to explore their potential roles in epileptogenesis. Lithium Chloride 92-108 neuron navigator 1 Rattus norvegicus 41-45 26544628-10 2015 Lithium chloride (LiCl, a GSK-3beta inhibitor) reduced Dex-induced inhibition of the classical WNT/beta-catenin pathway in TSCs and of the differentiation of TSCs to adipocytes. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Rattus norvegicus 26-35 25044369-0 2015 Lithium chloride promotes the odontoblast differentiation of hair follicle neural crest cells by activating Wnt/beta-catenin signaling. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 112-124 25044369-6 2015 The effects of LiCl on odontoblast differentiation of hfNCCs showed that proliferation and expression of beta-catenin in the cytosolic and nuclear compartments were increased in the LiCl-treated hfNCCs, and the pluripotency marks, Oct4, Klf4, Sox2 and Nanog, were more highly expressed in the LiCl-treated group than in the control group. Lithium Chloride 15-19 catenin beta 1 Homo sapiens 105-117 25044369-6 2015 The effects of LiCl on odontoblast differentiation of hfNCCs showed that proliferation and expression of beta-catenin in the cytosolic and nuclear compartments were increased in the LiCl-treated hfNCCs, and the pluripotency marks, Oct4, Klf4, Sox2 and Nanog, were more highly expressed in the LiCl-treated group than in the control group. Lithium Chloride 182-186 catenin beta 1 Homo sapiens 105-117 25044369-6 2015 The effects of LiCl on odontoblast differentiation of hfNCCs showed that proliferation and expression of beta-catenin in the cytosolic and nuclear compartments were increased in the LiCl-treated hfNCCs, and the pluripotency marks, Oct4, Klf4, Sox2 and Nanog, were more highly expressed in the LiCl-treated group than in the control group. Lithium Chloride 182-186 POU class 5 homeobox 1 Homo sapiens 231-235 25044369-6 2015 The effects of LiCl on odontoblast differentiation of hfNCCs showed that proliferation and expression of beta-catenin in the cytosolic and nuclear compartments were increased in the LiCl-treated hfNCCs, and the pluripotency marks, Oct4, Klf4, Sox2 and Nanog, were more highly expressed in the LiCl-treated group than in the control group. Lithium Chloride 182-186 Kruppel like factor 4 Homo sapiens 237-241 25044369-6 2015 The effects of LiCl on odontoblast differentiation of hfNCCs showed that proliferation and expression of beta-catenin in the cytosolic and nuclear compartments were increased in the LiCl-treated hfNCCs, and the pluripotency marks, Oct4, Klf4, Sox2 and Nanog, were more highly expressed in the LiCl-treated group than in the control group. Lithium Chloride 182-186 SRY-box transcription factor 2 Homo sapiens 243-247 25044369-6 2015 The effects of LiCl on odontoblast differentiation of hfNCCs showed that proliferation and expression of beta-catenin in the cytosolic and nuclear compartments were increased in the LiCl-treated hfNCCs, and the pluripotency marks, Oct4, Klf4, Sox2 and Nanog, were more highly expressed in the LiCl-treated group than in the control group. Lithium Chloride 182-186 Nanog homeobox Homo sapiens 252-257 25044369-6 2015 The effects of LiCl on odontoblast differentiation of hfNCCs showed that proliferation and expression of beta-catenin in the cytosolic and nuclear compartments were increased in the LiCl-treated hfNCCs, and the pluripotency marks, Oct4, Klf4, Sox2 and Nanog, were more highly expressed in the LiCl-treated group than in the control group. Lithium Chloride 182-186 catenin beta 1 Homo sapiens 105-117 25044369-6 2015 The effects of LiCl on odontoblast differentiation of hfNCCs showed that proliferation and expression of beta-catenin in the cytosolic and nuclear compartments were increased in the LiCl-treated hfNCCs, and the pluripotency marks, Oct4, Klf4, Sox2 and Nanog, were more highly expressed in the LiCl-treated group than in the control group. Lithium Chloride 182-186 POU class 5 homeobox 1 Homo sapiens 231-235 25044369-6 2015 The effects of LiCl on odontoblast differentiation of hfNCCs showed that proliferation and expression of beta-catenin in the cytosolic and nuclear compartments were increased in the LiCl-treated hfNCCs, and the pluripotency marks, Oct4, Klf4, Sox2 and Nanog, were more highly expressed in the LiCl-treated group than in the control group. Lithium Chloride 182-186 Kruppel like factor 4 Homo sapiens 237-241 25044369-6 2015 The effects of LiCl on odontoblast differentiation of hfNCCs showed that proliferation and expression of beta-catenin in the cytosolic and nuclear compartments were increased in the LiCl-treated hfNCCs, and the pluripotency marks, Oct4, Klf4, Sox2 and Nanog, were more highly expressed in the LiCl-treated group than in the control group. Lithium Chloride 182-186 SRY-box transcription factor 2 Homo sapiens 243-247 25044369-6 2015 The effects of LiCl on odontoblast differentiation of hfNCCs showed that proliferation and expression of beta-catenin in the cytosolic and nuclear compartments were increased in the LiCl-treated hfNCCs, and the pluripotency marks, Oct4, Klf4, Sox2 and Nanog, were more highly expressed in the LiCl-treated group than in the control group. Lithium Chloride 182-186 Nanog homeobox Homo sapiens 252-257 25044369-8 2015 Expression of beta-catenin in the nuclear of LiCl-treated hfNCCs induced by DC-CM was higher than in the other groups. Lithium Chloride 45-49 catenin beta 1 Homo sapiens 14-26 26544628-10 2015 Lithium chloride (LiCl, a GSK-3beta inhibitor) reduced Dex-induced inhibition of the classical WNT/beta-catenin pathway in TSCs and of the differentiation of TSCs to adipocytes. Lithium Chloride 0-16 Wnt family member 2 Rattus norvegicus 95-98 26544628-10 2015 Lithium chloride (LiCl, a GSK-3beta inhibitor) reduced Dex-induced inhibition of the classical WNT/beta-catenin pathway in TSCs and of the differentiation of TSCs to adipocytes. Lithium Chloride 0-16 catenin beta 1 Rattus norvegicus 99-111 26544628-10 2015 Lithium chloride (LiCl, a GSK-3beta inhibitor) reduced Dex-induced inhibition of the classical WNT/beta-catenin pathway in TSCs and of the differentiation of TSCs to adipocytes. Lithium Chloride 18-22 glycogen synthase kinase 3 beta Rattus norvegicus 26-35 26544628-10 2015 Lithium chloride (LiCl, a GSK-3beta inhibitor) reduced Dex-induced inhibition of the classical WNT/beta-catenin pathway in TSCs and of the differentiation of TSCs to adipocytes. Lithium Chloride 18-22 Wnt family member 2 Rattus norvegicus 95-98 26544628-10 2015 Lithium chloride (LiCl, a GSK-3beta inhibitor) reduced Dex-induced inhibition of the classical WNT/beta-catenin pathway in TSCs and of the differentiation of TSCs to adipocytes. Lithium Chloride 18-22 catenin beta 1 Rattus norvegicus 99-111 24916026-12 2015 Moreover, supplementation of LiCl induced beta-catenin accumulation and Runx2 expression. Lithium Chloride 29-33 catenin beta 1 Canis lupus familiaris 42-54 24916026-12 2015 Moreover, supplementation of LiCl induced beta-catenin accumulation and Runx2 expression. Lithium Chloride 29-33 runt related transcription factor 2 Canis lupus familiaris 72-77 25224036-8 2014 LiCl stimulated the nuclear translocation of Nrf2 and the transactivation of the Nrf2 target gene HO-1. Lithium Chloride 0-4 NFE2 like bZIP transcription factor 2 Rattus norvegicus 45-49 25223889-8 2014 Complete absence of GP29 mediated protection with down regulated NO and IL-12 production and dominant IL-10 production in presence of the GSK3beta inhibitor, Lithium chloride reiterated the role of GSK3beta in disease resolution in the murine model of visceral leishmaniasis. Lithium Chloride 158-174 glycogen synthase kinase 3 beta Mus musculus 138-146 25223889-8 2014 Complete absence of GP29 mediated protection with down regulated NO and IL-12 production and dominant IL-10 production in presence of the GSK3beta inhibitor, Lithium chloride reiterated the role of GSK3beta in disease resolution in the murine model of visceral leishmaniasis. Lithium Chloride 158-174 glycogen synthase kinase 3 beta Mus musculus 198-206 25557483-8 2015 Inhibition of the GSK-3ss by lithium chloride treatment rescued a significant number of cells from cytolysis in JEV acute infection, which coincided with the levels of cyclin D1 that escaped from proteolysis. Lithium Chloride 29-45 cyclin D1 Homo sapiens 168-177 26096168-6 2015 Lithium chloride (LiCl), a GSK-3beta inhibitor (60 mg/kg) was used orally from third to eighth week. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Rattus norvegicus 27-36 25224036-8 2014 LiCl stimulated the nuclear translocation of Nrf2 and the transactivation of the Nrf2 target gene HO-1. Lithium Chloride 0-4 NFE2 like bZIP transcription factor 2 Rattus norvegicus 81-85 25224036-8 2014 LiCl stimulated the nuclear translocation of Nrf2 and the transactivation of the Nrf2 target gene HO-1. Lithium Chloride 0-4 heme oxygenase 1 Rattus norvegicus 98-102 25951661-0 2014 Effect of lithium chloride on endoplasmic reticulum stress-related PERK/ROCK signaling in a rat model of glaucoma. Lithium Chloride 10-26 Rho-associated coiled-coil containing protein kinase 1 Rattus norvegicus 72-76 25951661-2 2014 Lithium chloride (LiCl) inhibits glycogen synthase kinase-3 beta (GSK-3beta) and attends PERK-induced endoplasmic reticulum stress (ERs) transition. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Rattus norvegicus 33-64 25951661-2 2014 Lithium chloride (LiCl) inhibits glycogen synthase kinase-3 beta (GSK-3beta) and attends PERK-induced endoplasmic reticulum stress (ERs) transition. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Rattus norvegicus 66-75 25951661-2 2014 Lithium chloride (LiCl) inhibits glycogen synthase kinase-3 beta (GSK-3beta) and attends PERK-induced endoplasmic reticulum stress (ERs) transition. Lithium Chloride 18-22 glycogen synthase kinase 3 beta Rattus norvegicus 33-64 25951661-2 2014 Lithium chloride (LiCl) inhibits glycogen synthase kinase-3 beta (GSK-3beta) and attends PERK-induced endoplasmic reticulum stress (ERs) transition. Lithium Chloride 18-22 glycogen synthase kinase 3 beta Rattus norvegicus 66-75 25951661-8 2014 LiCl treatment activated PERK and inhibited the expression of ROCK-1 and ROCK-2 in a rat model of glaucoma. Lithium Chloride 0-4 Rho-associated coiled-coil containing protein kinase 1 Rattus norvegicus 62-68 25951661-8 2014 LiCl treatment activated PERK and inhibited the expression of ROCK-1 and ROCK-2 in a rat model of glaucoma. Lithium Chloride 0-4 Rho-associated coiled-coil containing protein kinase 2 Rattus norvegicus 73-79 25951661-9 2014 Collectively, these results suggest that LiCl reduced the IOP through the phosphorylation of PERK by the regulation of PERK/ROCK signaling in glaucoma rat model. Lithium Chloride 41-45 Rho-associated coiled-coil containing protein kinase 1 Rattus norvegicus 124-128 25038456-3 2014 We found that miR-709 expression was down-regulated during adipogenesis after MDI (1-methyl-3-isobutylxanthine, dexamethasone and insulin) stimulation in normal cultured 3T3-L1 cells, while up-regulated after LiCl treatment. Lithium Chloride 209-213 microRNA 709 Mus musculus 14-21 25409333-12 2014 IL-10, MCP-1, and TNF were significantly increased in animals treated with LiCl compared to NaCl. Lithium Chloride 75-79 interleukin 10 Homo sapiens 0-5 25409333-12 2014 IL-10, MCP-1, and TNF were significantly increased in animals treated with LiCl compared to NaCl. Lithium Chloride 75-79 C-C motif chemokine ligand 2 Homo sapiens 7-12 25409333-12 2014 IL-10, MCP-1, and TNF were significantly increased in animals treated with LiCl compared to NaCl. Lithium Chloride 75-79 tumor necrosis factor Homo sapiens 18-21 25132065-8 2014 LiCl also inhibited apoptosis of cells in the decline phase of growth by increasing Bcl-2 expression. Lithium Chloride 0-4 apoptosis regulator Bcl-2 Cricetulus griseus 84-89 24949891-7 2014 Treatment with LiCl, a GSK-3beta inhibitor, and inhibition of PPARgamma expression suppressed the accelerated adipogenesis of shPP2A cells. Lithium Chloride 15-19 glycogen synthase kinase 3 beta Mus musculus 23-32 25352117-8 2014 Incubation of TM cells with lithium chloride increased the expression of active beta-catenin. Lithium Chloride 28-44 catenin beta 1 Homo sapiens 80-92 25195717-7 2014 The effects of puerarin could be partially blocked by pharmacologic inhibition of PI3K and the glycogen synthase kinase 3beta (GSK-3beta) pathways with LY294002 and LiCl, respectively. Lithium Chloride 165-169 glycogen synthase kinase 3 beta Rattus norvegicus 95-125 25195717-7 2014 The effects of puerarin could be partially blocked by pharmacologic inhibition of PI3K and the glycogen synthase kinase 3beta (GSK-3beta) pathways with LY294002 and LiCl, respectively. Lithium Chloride 165-169 glycogen synthase kinase 3 beta Rattus norvegicus 127-136 25073408-2 2014 We previously showed that the overexpression of POG1 conferred tolerance to high concentrations of LiCl and sugar on laboratory and baker"s yeast strains, respectively. Lithium Chloride 99-103 Pog1p Saccharomyces cerevisiae S288C 48-52 24946283-9 2014 Further, LiCl treatment induced OATP1B3 mRNA expression in KYN-2 cells, indicating a strong association between OATP1B3 expression and Wnt/beta-catenin signalling. Lithium Chloride 9-13 solute carrier organic anion transporter family member 1B3 Homo sapiens 32-39 24946283-9 2014 Further, LiCl treatment induced OATP1B3 mRNA expression in KYN-2 cells, indicating a strong association between OATP1B3 expression and Wnt/beta-catenin signalling. Lithium Chloride 9-13 solute carrier organic anion transporter family member 1B3 Homo sapiens 112-119 24946283-9 2014 Further, LiCl treatment induced OATP1B3 mRNA expression in KYN-2 cells, indicating a strong association between OATP1B3 expression and Wnt/beta-catenin signalling. Lithium Chloride 9-13 catenin beta 1 Homo sapiens 139-151 25223979-8 2014 Orexin receptors in the CeA appear to intervene in the association of a flavor with orosensory stimuli, e.g., a sweet and pleasant taste, but could be unnecessary when the association is established with visceral stimuli, e.g., lithium chloride. Lithium Chloride 228-244 carcinoembryonic antigen gene family 4 Rattus norvegicus 24-27 25350285-8 2014 Heterologous expression in salt sensitive yeast mutant AXT3 complemented for the loss of yeast vacuolar NHX1 under NaCl, KCl and LiCl stress indicating that VrNHX1 was the orthologue of ScNHX1. Lithium Chloride 129-133 bifunctional K:H/Na:H antiporter NHX1 Saccharomyces cerevisiae S288C 104-108 25350285-8 2014 Heterologous expression in salt sensitive yeast mutant AXT3 complemented for the loss of yeast vacuolar NHX1 under NaCl, KCl and LiCl stress indicating that VrNHX1 was the orthologue of ScNHX1. Lithium Chloride 129-133 sodium/hydrogen exchanger 2-like Vigna radiata 157-163 25352117-9 2014 Lithium chloride treatment upregulated miR-29b expression, and suppressed the levels of various ECM proteins under both basal and TGF-beta2 stimulatory conditions. Lithium Chloride 0-16 microRNA 29b-1 Homo sapiens 39-46 25352117-9 2014 Lithium chloride treatment upregulated miR-29b expression, and suppressed the levels of various ECM proteins under both basal and TGF-beta2 stimulatory conditions. Lithium Chloride 0-16 transforming growth factor beta 2 Homo sapiens 130-139 25126703-8 2014 Selective GSK-3beta inhibitors, LiCl and TDZD, treatment ameliorates remifentanil-induced postoperative hyperalgesia, and this was associated with the downregulated GluR1 subunit in the membrane fraction (254 +- 23.51 vs 119 +- 14.74, P = 0.0027; 254 +- 23.51 vs 124 +- 9.35, P = 0.0032). Lithium Chloride 32-36 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 165-170 28324386-2 2014 In this study, three compounds including propionic acid, lithium chloride and butyric acid were added to the medium which decreased acetate levels and enhanced recombinant protein production (alpha-synuclein). Lithium Chloride 57-73 synuclein alpha Homo sapiens 192-207 25187518-10 2014 The oxidative stress-induced mitochondrial translocation of GSK-3beta was associated with an increase in cell death, which was suppressed by lithium chloride (LiCl), a GSK-3beta inhibitor. Lithium Chloride 141-157 glycogen synthase kinase 3 beta Homo sapiens 60-69 25187518-10 2014 The oxidative stress-induced mitochondrial translocation of GSK-3beta was associated with an increase in cell death, which was suppressed by lithium chloride (LiCl), a GSK-3beta inhibitor. Lithium Chloride 141-157 glycogen synthase kinase 3 beta Homo sapiens 168-177 25187518-10 2014 The oxidative stress-induced mitochondrial translocation of GSK-3beta was associated with an increase in cell death, which was suppressed by lithium chloride (LiCl), a GSK-3beta inhibitor. Lithium Chloride 159-163 glycogen synthase kinase 3 beta Homo sapiens 60-69 25187518-10 2014 The oxidative stress-induced mitochondrial translocation of GSK-3beta was associated with an increase in cell death, which was suppressed by lithium chloride (LiCl), a GSK-3beta inhibitor. Lithium Chloride 159-163 glycogen synthase kinase 3 beta Homo sapiens 168-177 24975844-6 2014 Blocking Glycogen Synthase Kinase (GSK3beta) activity by lithium chloride or Dvl gene overexpression restored beta-catenin expression. Lithium Chloride 57-73 glycogen synthase kinase 3 beta Homo sapiens 35-43 25147335-5 2014 Oscillatory shear stress-induced Ang-2 and Axin-2 mRNA expression was downregulated in the presence of a Wnt inhibitor, IWR-1, but was upregulated in the presence of a Wnt agonist, LiCl. Lithium Chloride 181-185 angiopoietin 2a Danio rerio 33-38 25147335-5 2014 Oscillatory shear stress-induced Ang-2 and Axin-2 mRNA expression was downregulated in the presence of a Wnt inhibitor, IWR-1, but was upregulated in the presence of a Wnt agonist, LiCl. Lithium Chloride 181-185 axin 2 (conductin, axil) Danio rerio 43-49 24975844-6 2014 Blocking Glycogen Synthase Kinase (GSK3beta) activity by lithium chloride or Dvl gene overexpression restored beta-catenin expression. Lithium Chloride 57-73 catenin beta 1 Homo sapiens 110-122 25056693-3 2014 Here, either gsk3b knockdown by morpholino or Gsk3b loss of activity by LiCl treatment had serious phenotypic consequences, such as defects in the positioning and patterning of intersegmental blood vessels and reduction of vegfaa121 and vegfaa165 transcripts. Lithium Chloride 72-76 glycogen synthase kinase 3 beta, genome duplicate a Danio rerio 46-51 24740553-10 2014 In immunohistochemistry, beta-catenin was more potent in response to LiCl (an activator of the pathway) treatment. Lithium Chloride 69-73 catenin beta 1 Homo sapiens 25-37 24878992-4 2014 Lithium chloride (LiCl) is an activator of Wnt/beta-catenin signaling through stabilizing beta-catenin. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 47-59 24878992-4 2014 Lithium chloride (LiCl) is an activator of Wnt/beta-catenin signaling through stabilizing beta-catenin. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 90-102 24878992-4 2014 Lithium chloride (LiCl) is an activator of Wnt/beta-catenin signaling through stabilizing beta-catenin. Lithium Chloride 18-22 catenin beta 1 Homo sapiens 47-59 24878992-4 2014 Lithium chloride (LiCl) is an activator of Wnt/beta-catenin signaling through stabilizing beta-catenin. Lithium Chloride 18-22 catenin beta 1 Homo sapiens 90-102 24878992-5 2014 We found that CTSB can relieve the anti-adipogenic effects of LiCl, indicating that CTSB could impact Wnt/beta-catenin signaling pathway. Lithium Chloride 62-66 cathepsin B Homo sapiens 14-18 24878992-5 2014 We found that CTSB can relieve the anti-adipogenic effects of LiCl, indicating that CTSB could impact Wnt/beta-catenin signaling pathway. Lithium Chloride 62-66 catenin beta 1 Homo sapiens 106-118 25081282-8 2014 Using a transwell assay, we found that accumulated beta-catenin induced by Grp58 knockdown or lithium chloride treatment inhibited the migration ability of HeLa cells. Lithium Chloride 94-110 catenin beta 1 Homo sapiens 51-63 24894198-7 2014 Moreover, GSK3beta deletion or GSK3beta inhibition by LiCl treatment resulted in increased p21 expression and reduced Sox2 expression in osteosarcoma cells. Lithium Chloride 54-58 glycogen synthase kinase 3 beta Homo sapiens 10-18 24894198-7 2014 Moreover, GSK3beta deletion or GSK3beta inhibition by LiCl treatment resulted in increased p21 expression and reduced Sox2 expression in osteosarcoma cells. Lithium Chloride 54-58 glycogen synthase kinase 3 beta Homo sapiens 31-39 24894198-7 2014 Moreover, GSK3beta deletion or GSK3beta inhibition by LiCl treatment resulted in increased p21 expression and reduced Sox2 expression in osteosarcoma cells. Lithium Chloride 54-58 H3 histone pseudogene 16 Homo sapiens 91-94 24894198-7 2014 Moreover, GSK3beta deletion or GSK3beta inhibition by LiCl treatment resulted in increased p21 expression and reduced Sox2 expression in osteosarcoma cells. Lithium Chloride 54-58 SRY-box transcription factor 2 Homo sapiens 118-122 25148525-7 2014 Inhibition of GSK3beta with LiCl (the inhibitor of GSK3beta) increased the expression of Snail and beta-catenin in cultured kidney epithelial cells. Lithium Chloride 28-32 glycogen synthase kinase 3 beta Homo sapiens 14-22 25148525-7 2014 Inhibition of GSK3beta with LiCl (the inhibitor of GSK3beta) increased the expression of Snail and beta-catenin in cultured kidney epithelial cells. Lithium Chloride 28-32 glycogen synthase kinase 3 beta Homo sapiens 51-59 25148525-7 2014 Inhibition of GSK3beta with LiCl (the inhibitor of GSK3beta) increased the expression of Snail and beta-catenin in cultured kidney epithelial cells. Lithium Chloride 28-32 snail family transcriptional repressor 1 Homo sapiens 89-94 25148525-7 2014 Inhibition of GSK3beta with LiCl (the inhibitor of GSK3beta) increased the expression of Snail and beta-catenin in cultured kidney epithelial cells. Lithium Chloride 28-32 catenin beta 1 Homo sapiens 99-111 25100168-0 2014 Dose-dependent protective effect of lithium chloride on retinal ganglion cells is interrelated with an upregulated intraretinal BDNF after optic nerve transection in adult rats. Lithium Chloride 36-52 brain-derived neurotrophic factor Rattus norvegicus 128-132 25001409-8 2014 We also found that other environmental stresses, such as high temperature, H2O2, and LiCl, also promoted endocytosis of Gap1p. Lithium Chloride 85-89 amino acid permease GAP1 Saccharomyces cerevisiae S288C 120-125 25100168-6 2014 Similar promotion and decline in the mRNA and protein levels of intraretinal BDNF were also found at the 14 day point, while such BDNF levels increased in the 30 mg/kg bw LiCl group but peaked in the 60 and 85 mg/kg bw LiCl groups at the 7 day point. Lithium Chloride 171-175 brain-derived neurotrophic factor Rattus norvegicus 130-134 25100168-6 2014 Similar promotion and decline in the mRNA and protein levels of intraretinal BDNF were also found at the 14 day point, while such BDNF levels increased in the 30 mg/kg bw LiCl group but peaked in the 60 and 85 mg/kg bw LiCl groups at the 7 day point. Lithium Chloride 219-223 brain-derived neurotrophic factor Rattus norvegicus 77-81 25029272-13 2014 Interestingly, we observed that the Pax6/Pax6(5a) expressing mouse fibroblast cell lines were less responsive to canonical Wnt pathway stimulation than the control cell line when TOP/FOP activity and the levels of active beta-catenin and GSK3-beta Ser9 phosphorylation were measured after LiCl stimulation. Lithium Chloride 289-293 paired box 6 Mus musculus 36-40 24803542-5 2014 In the murine air pouch model of inflammation, lithium chloride (LiCl) amplified TNF-alpha release. Lithium Chloride 47-63 tumor necrosis factor Homo sapiens 81-90 24803542-5 2014 In the murine air pouch model of inflammation, lithium chloride (LiCl) amplified TNF-alpha release. Lithium Chloride 65-69 tumor necrosis factor Homo sapiens 81-90 24803542-6 2014 In lipopolysaccharide-stimulated human neutrophils, GSK-3 inhibitors mimicked the effect of LiCl, each potentiating TNF-alpha release after 4 h, in a concentration-dependent fashion, by up to a 3-fold increase (ED50 of 1 mM for lithium). Lithium Chloride 92-96 tumor necrosis factor Homo sapiens 116-125 25082888-10 2014 Furthermore, inhibition of glycogen synthase kinase-3beta (GSK-3beta) with LiCl was able to protect glia cells, whereas inhibition of the calpain with calpain inhibitor III protected only neurons. Lithium Chloride 75-79 glycogen synthase kinase 3 beta Rattus norvegicus 27-57 25082888-10 2014 Furthermore, inhibition of glycogen synthase kinase-3beta (GSK-3beta) with LiCl was able to protect glia cells, whereas inhibition of the calpain with calpain inhibitor III protected only neurons. Lithium Chloride 75-79 glycogen synthase kinase 3 beta Rattus norvegicus 59-68 25029272-13 2014 Interestingly, we observed that the Pax6/Pax6(5a) expressing mouse fibroblast cell lines were less responsive to canonical Wnt pathway stimulation than the control cell line when TOP/FOP activity and the levels of active beta-catenin and GSK3-beta Ser9 phosphorylation were measured after LiCl stimulation. Lithium Chloride 289-293 paired box 6 Mus musculus 41-45 26819974-0 2014 Reentrant condensation of lysozyme: Implications for studying dynamics of lysozyme in aqueous solutions of lithium chloride. Lithium Chloride 107-123 lysozyme Homo sapiens 26-34 24866384-10 2014 Finally, LiCl, a GSK3 inhibitor, and beta-catenin overexpression rescued endothelial integrity and adherens junction organization, induced by fzd7 deletion. Lithium Chloride 9-13 frizzled class receptor 7 Mus musculus 142-146 24563318-0 2014 Lithium chloride inhibits TGF-beta1-induced myofibroblast transdifferentiation via PI3K/Akt pathway in cultured fibroblasts from Tenon"s capsule of the human eye. Lithium Chloride 0-16 transforming growth factor beta 1 Homo sapiens 26-35 24563318-0 2014 Lithium chloride inhibits TGF-beta1-induced myofibroblast transdifferentiation via PI3K/Akt pathway in cultured fibroblasts from Tenon"s capsule of the human eye. Lithium Chloride 0-16 AKT serine/threonine kinase 1 Homo sapiens 88-91 24563318-5 2014 LiCl treatment reduced expression of TGF-beta1-induced alpha-SMA expression in HTFs. Lithium Chloride 0-4 transforming growth factor beta 1 Homo sapiens 37-46 24563318-6 2014 LiCl also decreased Akt phosphorylation induced by TGF-beta1. Lithium Chloride 0-4 AKT serine/threonine kinase 1 Homo sapiens 20-23 24563318-6 2014 LiCl also decreased Akt phosphorylation induced by TGF-beta1. Lithium Chloride 0-4 transforming growth factor beta 1 Homo sapiens 51-60 24563318-8 2014 Thus, LiCl induces the suppression of transdifferentiation stimulated by TGF-beta1 by the regulation of PI3K/Akt signaling in HTFs. Lithium Chloride 6-10 transforming growth factor beta 1 Homo sapiens 73-82 24563318-8 2014 Thus, LiCl induces the suppression of transdifferentiation stimulated by TGF-beta1 by the regulation of PI3K/Akt signaling in HTFs. Lithium Chloride 6-10 AKT serine/threonine kinase 1 Homo sapiens 109-112 24929002-7 2014 Similar to Wnt, LiCl prevented the degradation of beta-catenin and, thus, attenuated allergic airway inflammation and hyperresponsiveness. Lithium Chloride 16-20 catenin (cadherin associated protein), beta 1 Mus musculus 50-62 24627571-13 2014 Lithium chloride (an inhibitor of GSK-3beta) treatment increased activated beta-catenin protein levels, significantly decreased activated GSK-3beta and restored cartilaginous callus formation and endochondral ossification. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Mus musculus 34-43 24627571-13 2014 Lithium chloride (an inhibitor of GSK-3beta) treatment increased activated beta-catenin protein levels, significantly decreased activated GSK-3beta and restored cartilaginous callus formation and endochondral ossification. Lithium Chloride 0-16 catenin (cadherin associated protein), beta 1 Mus musculus 75-87 24627571-13 2014 Lithium chloride (an inhibitor of GSK-3beta) treatment increased activated beta-catenin protein levels, significantly decreased activated GSK-3beta and restored cartilaginous callus formation and endochondral ossification. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Mus musculus 138-147 24798646-9 2014 Lithium chloride (LiCl) is an activator of Wnt/beta-catenin signaling, which is an inhibitor of glycogen synthetase kinase-3 (GSK-3), maintaining the stability of beta-catenin in cytosolic. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 47-59 24798646-9 2014 Lithium chloride (LiCl) is an activator of Wnt/beta-catenin signaling, which is an inhibitor of glycogen synthetase kinase-3 (GSK-3), maintaining the stability of beta-catenin in cytosolic. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 163-175 24798646-9 2014 Lithium chloride (LiCl) is an activator of Wnt/beta-catenin signaling, which is an inhibitor of glycogen synthetase kinase-3 (GSK-3), maintaining the stability of beta-catenin in cytosolic. Lithium Chloride 18-22 catenin beta 1 Homo sapiens 47-59 24798646-9 2014 Lithium chloride (LiCl) is an activator of Wnt/beta-catenin signaling, which is an inhibitor of glycogen synthetase kinase-3 (GSK-3), maintaining the stability of beta-catenin in cytosolic. Lithium Chloride 18-22 catenin beta 1 Homo sapiens 163-175 26819974-0 2014 Reentrant condensation of lysozyme: Implications for studying dynamics of lysozyme in aqueous solutions of lithium chloride. Lithium Chloride 107-123 lysozyme Homo sapiens 74-82 26819974-1 2014 Recent studies have outlined the use of eutectic solutions of lithium chloride in water to study microscopic dynamics of lysozyme in an aqueous solvent that is remarkably similar to pure water in many respects, yet allows experiments over a wide temperature range without solvent crystallization. Lithium Chloride 62-78 lysozyme Homo sapiens 121-129 24932283-5 2014 Lithium chloride, an agonist known to activate the Wnt/beta-catenin signaling pathway, attenuated the casticin-induced downregulation of beta-catenin protein expression and inhibited the self-renewal capacity. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 55-67 24549719-0 2014 Lithium chloride decreases proliferation and migration of C6 glioma cells harboring isocitrate dehydrogenase 2 mutant via GSK-3beta. Lithium Chloride 0-16 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 84-108 24549719-0 2014 Lithium chloride decreases proliferation and migration of C6 glioma cells harboring isocitrate dehydrogenase 2 mutant via GSK-3beta. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Homo sapiens 122-131 24549719-4 2014 The mechanism of lithium chloride on C6 glioma cells harboring IDH2 mutation has not been studied. Lithium Chloride 17-33 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 63-67 24549719-5 2014 Here, we found lithium chloride induced inhibitive effects on cell proliferation of both C6 glioma cells with and without IDH2 mutation, although IDH2 mutation increased the stability of HIF-1alpha. Lithium Chloride 15-31 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 122-126 24549719-6 2014 GSK-3beta could be phosphorylated at Ser9 and its activity was inhibited when C6 glioma cells were treated by lithium chloride. Lithium Chloride 110-126 glycogen synthase kinase 3 beta Homo sapiens 0-9 24549719-9 2014 Moreover, although the beta-catenin and HIF-1alpha increased the secretion of metalloproteinase-2,-9 in C6 glioma cells harboring IDH2 mutation, the migration potential of lithium chloride-treated C6 glioma cells harboring the IDH2 and its mutant was uniform. Lithium Chloride 172-188 catenin beta 1 Homo sapiens 23-35 24549719-9 2014 Moreover, although the beta-catenin and HIF-1alpha increased the secretion of metalloproteinase-2,-9 in C6 glioma cells harboring IDH2 mutation, the migration potential of lithium chloride-treated C6 glioma cells harboring the IDH2 and its mutant was uniform. Lithium Chloride 172-188 hypoxia inducible factor 1 subunit alpha Homo sapiens 40-50 24549719-9 2014 Moreover, although the beta-catenin and HIF-1alpha increased the secretion of metalloproteinase-2,-9 in C6 glioma cells harboring IDH2 mutation, the migration potential of lithium chloride-treated C6 glioma cells harboring the IDH2 and its mutant was uniform. Lithium Chloride 172-188 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 130-134 24549719-9 2014 Moreover, although the beta-catenin and HIF-1alpha increased the secretion of metalloproteinase-2,-9 in C6 glioma cells harboring IDH2 mutation, the migration potential of lithium chloride-treated C6 glioma cells harboring the IDH2 and its mutant was uniform. Lithium Chloride 172-188 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 227-231 24549719-10 2014 These results indicated lithium chloride could decrease the proliferation and migration potential of C6 glioma cells harboring IDH2 mutation. Lithium Chloride 24-40 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 127-131 24464479-11 2014 More importantly, blockage of GSK-3beta activity with the GSK-3beta inhibitor lithium chloride could attenuate Mn-induced downregulation of beta-catenin and survivin as well as neuronal apoptosis. Lithium Chloride 78-94 glycogen synthase kinase 3 beta Rattus norvegicus 30-39 24464479-11 2014 More importantly, blockage of GSK-3beta activity with the GSK-3beta inhibitor lithium chloride could attenuate Mn-induced downregulation of beta-catenin and survivin as well as neuronal apoptosis. Lithium Chloride 78-94 glycogen synthase kinase 3 beta Rattus norvegicus 58-67 24464479-11 2014 More importantly, blockage of GSK-3beta activity with the GSK-3beta inhibitor lithium chloride could attenuate Mn-induced downregulation of beta-catenin and survivin as well as neuronal apoptosis. Lithium Chloride 78-94 catenin beta 1 Rattus norvegicus 140-152 24932283-5 2014 Lithium chloride, an agonist known to activate the Wnt/beta-catenin signaling pathway, attenuated the casticin-induced downregulation of beta-catenin protein expression and inhibited the self-renewal capacity. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 137-149 24661612-7 2014 Furthermore, for the newly developed hybrids the activity of phenolic peroxidase in the cell wall was analysed in apoplastic washing fluids and after sequential extraction of cell-wall material with CaCl2 and LiCl. Lithium Chloride 209-213 peroxidase 1 Zea mays 70-80 24598771-9 2014 In contrast, the GSK3beta inhibitor lithium chloride significantly reduced tau hyperphosphorylation in GRK5-defective APP (swe) mice, but failed to enhance PKC activity and ACh release in the hippocampi of GRK5-defective APP (swe) mice. Lithium Chloride 36-52 glycogen synthase kinase 3 alpha Mus musculus 17-25 24837604-10 2014 In addition, we found that ETOH-induced activation of PDCD4 was inhibited by pharmacologic blockade of GSK-3beta using inhibitors, lithium chloride (LiCl) and SB-216763 or siRNA mediated silencing of GSK-3beta. Lithium Chloride 131-147 programmed cell death 4 Rattus norvegicus 54-59 24837604-10 2014 In addition, we found that ETOH-induced activation of PDCD4 was inhibited by pharmacologic blockade of GSK-3beta using inhibitors, lithium chloride (LiCl) and SB-216763 or siRNA mediated silencing of GSK-3beta. Lithium Chloride 131-147 glycogen synthase kinase 3 beta Rattus norvegicus 103-112 24837604-10 2014 In addition, we found that ETOH-induced activation of PDCD4 was inhibited by pharmacologic blockade of GSK-3beta using inhibitors, lithium chloride (LiCl) and SB-216763 or siRNA mediated silencing of GSK-3beta. Lithium Chloride 149-153 programmed cell death 4 Rattus norvegicus 54-59 24837604-10 2014 In addition, we found that ETOH-induced activation of PDCD4 was inhibited by pharmacologic blockade of GSK-3beta using inhibitors, lithium chloride (LiCl) and SB-216763 or siRNA mediated silencing of GSK-3beta. Lithium Chloride 149-153 glycogen synthase kinase 3 beta Rattus norvegicus 103-112 24598771-9 2014 In contrast, the GSK3beta inhibitor lithium chloride significantly reduced tau hyperphosphorylation in GRK5-defective APP (swe) mice, but failed to enhance PKC activity and ACh release in the hippocampi of GRK5-defective APP (swe) mice. Lithium Chloride 36-52 G protein-coupled receptor kinase 5 Mus musculus 103-107 24598771-9 2014 In contrast, the GSK3beta inhibitor lithium chloride significantly reduced tau hyperphosphorylation in GRK5-defective APP (swe) mice, but failed to enhance PKC activity and ACh release in the hippocampi of GRK5-defective APP (swe) mice. Lithium Chloride 36-52 G protein-coupled receptor kinase 5 Mus musculus 206-210 24470226-3 2014 To understand the mechanism by which LiCl affects catabolic events in articular chondrocytes after IL-1beta treatment, the activation of NF-kappaB was determined using luciferase reporter assays, and the activities of MAPKs and the STAT-3 signaling pathway were determined by immunoblot analysis of total cell lysates. Lithium Chloride 37-41 interleukin 1 beta Mus musculus 99-107 24582760-1 2014 Lithium chloride at doses sufficient to induce conditioned taste aversion (CTA) causes c-Fos expression in the paraventricular nucleus and increases the plasma level of corticosterone with activation of the hypothalamic-pituitary-adrenal axis. Lithium Chloride 0-16 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 87-92 24470226-3 2014 To understand the mechanism by which LiCl affects catabolic events in articular chondrocytes after IL-1beta treatment, the activation of NF-kappaB was determined using luciferase reporter assays, and the activities of MAPKs and the STAT-3 signaling pathway were determined by immunoblot analysis of total cell lysates. Lithium Chloride 37-41 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 137-146 24470226-5 2014 RESULTS: LiCl treatment resulted in decreased catabolic marker messenger RNA levels and activation of NF-kappaB, p38 MAPK, and STAT-3 signaling in IL-1beta-treated articular chondrocytes. Lithium Chloride 9-13 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 102-111 24784865-15 2014 Decrease in Mre11 mRNA level upon LiCl treatment was suggested to be an important cause for the decreased DNA repair in T47D monolayer and spheroid cells. Lithium Chloride 34-38 MRE11 homolog, double strand break repair nuclease Homo sapiens 12-17 24470226-5 2014 RESULTS: LiCl treatment resulted in decreased catabolic marker messenger RNA levels and activation of NF-kappaB, p38 MAPK, and STAT-3 signaling in IL-1beta-treated articular chondrocytes. Lithium Chloride 9-13 mitogen-activated protein kinase 14 Mus musculus 113-116 24470226-5 2014 RESULTS: LiCl treatment resulted in decreased catabolic marker messenger RNA levels and activation of NF-kappaB, p38 MAPK, and STAT-3 signaling in IL-1beta-treated articular chondrocytes. Lithium Chloride 9-13 signal transducer and activator of transcription 3 Mus musculus 127-133 24470226-5 2014 RESULTS: LiCl treatment resulted in decreased catabolic marker messenger RNA levels and activation of NF-kappaB, p38 MAPK, and STAT-3 signaling in IL-1beta-treated articular chondrocytes. Lithium Chloride 9-13 interleukin 1 beta Mus musculus 147-155 24470226-6 2014 Furthermore, LiCl directly inhibited IL-6-stimulated activation of STAT-3 signaling. Lithium Chloride 13-17 interleukin 6 Mus musculus 37-41 24470226-6 2014 Furthermore, LiCl directly inhibited IL-6-stimulated activation of STAT-3 signaling. Lithium Chloride 13-17 signal transducer and activator of transcription 3 Mus musculus 67-73 24470226-7 2014 Consequently, the loss of proteoglycan and severity of cartilage destruction in LiCl-treated mouse knee joints 8 weeks after OA induction surgery or in LiCl-treated mouse femoral head explants after IL-1beta treatment were markedly reduced compared to that in vehicle-treated joints or explants. Lithium Chloride 80-84 interleukin 1 beta Mus musculus 199-207 24470226-7 2014 Consequently, the loss of proteoglycan and severity of cartilage destruction in LiCl-treated mouse knee joints 8 weeks after OA induction surgery or in LiCl-treated mouse femoral head explants after IL-1beta treatment were markedly reduced compared to that in vehicle-treated joints or explants. Lithium Chloride 152-156 interleukin 1 beta Mus musculus 199-207 24470226-8 2014 CONCLUSION: LiCl reduced catabolic events in IL-1beta-treated human articular chondrocytes and attenuated the severity of cartilage destruction in IL-1beta-treated mouse femoral head explants and in the knee joints of mice with surgically induced OA, acting via inhibition of the activities of the NF-kappaB, p38, and STAT-3 signaling pathways. Lithium Chloride 12-16 interleukin 1 beta Homo sapiens 45-53 24470226-8 2014 CONCLUSION: LiCl reduced catabolic events in IL-1beta-treated human articular chondrocytes and attenuated the severity of cartilage destruction in IL-1beta-treated mouse femoral head explants and in the knee joints of mice with surgically induced OA, acting via inhibition of the activities of the NF-kappaB, p38, and STAT-3 signaling pathways. Lithium Chloride 12-16 interleukin 1 beta Homo sapiens 147-155 24470226-8 2014 CONCLUSION: LiCl reduced catabolic events in IL-1beta-treated human articular chondrocytes and attenuated the severity of cartilage destruction in IL-1beta-treated mouse femoral head explants and in the knee joints of mice with surgically induced OA, acting via inhibition of the activities of the NF-kappaB, p38, and STAT-3 signaling pathways. Lithium Chloride 12-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 298-307 24470226-8 2014 CONCLUSION: LiCl reduced catabolic events in IL-1beta-treated human articular chondrocytes and attenuated the severity of cartilage destruction in IL-1beta-treated mouse femoral head explants and in the knee joints of mice with surgically induced OA, acting via inhibition of the activities of the NF-kappaB, p38, and STAT-3 signaling pathways. Lithium Chloride 12-16 mitogen-activated protein kinase 14 Mus musculus 309-312 24470226-8 2014 CONCLUSION: LiCl reduced catabolic events in IL-1beta-treated human articular chondrocytes and attenuated the severity of cartilage destruction in IL-1beta-treated mouse femoral head explants and in the knee joints of mice with surgically induced OA, acting via inhibition of the activities of the NF-kappaB, p38, and STAT-3 signaling pathways. Lithium Chloride 12-16 signal transducer and activator of transcription 3 Mus musculus 318-324 24610780-8 2014 Our results show that the GSK3beta kinase inhibitors LiCl, SB 216763, and SB 415286 prevent copper-responsive APP trafficking. Lithium Chloride 53-57 glycogen synthase kinase 3 beta Homo sapiens 26-34 25657782-12 2014 of lithium chloride reduced significantly the inflammatory response in cerulein-induced acute pancreatitis by ameliorating pancreatic edema and leukocyte infiltration, attenuating amylase and lipase serum levels, and myeloperoxidase activity compared to control group (p<0.05). Lithium Chloride 3-19 myeloperoxidase Mus musculus 217-232 24275700-6 2014 Accordingly, we demonstrated that chronic LiCl, but not aripiprazole, decreased phosphorylation of CREB at the Ser133 site and NA1 at the Ser896 site in the prefrontal cortex and GluA1 at the Ser831 site and NA2B at the Ser1303 site in the ventral striatum. Lithium Chloride 42-46 cAMP responsive element binding protein 1 Rattus norvegicus 99-103 24275700-6 2014 Accordingly, we demonstrated that chronic LiCl, but not aripiprazole, decreased phosphorylation of CREB at the Ser133 site and NA1 at the Ser896 site in the prefrontal cortex and GluA1 at the Ser831 site and NA2B at the Ser1303 site in the ventral striatum. Lithium Chloride 42-46 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 179-184 24571487-9 2014 These findings were recapitulated by treatment with the GSK-3beta inhibitor, LiCl. Lithium Chloride 77-81 glycogen synthase kinase 3 beta Homo sapiens 56-65 24586576-8 2014 Conversely, addition of both Wnt/beta-catenin activators CHIR98014 and lithium chloride enhanced the effect of high phosphate on BMP-2, calcium deposition and alkaline phosphatase activity. Lithium Chloride 71-87 catenin beta 1 Homo sapiens 33-45 24586576-8 2014 Conversely, addition of both Wnt/beta-catenin activators CHIR98014 and lithium chloride enhanced the effect of high phosphate on BMP-2, calcium deposition and alkaline phosphatase activity. Lithium Chloride 71-87 bone morphogenetic protein 2 Homo sapiens 129-134 24183963-6 2014 Furthermore, our data in the present study suggested that GLP-1 regulated tau phosphorylation induced by AGEs through a signaling pathway involving glycogen synthase kinase 3beta (GSK-3beta), similarly to the GSK-3beta inhibitor, lithium chloride. Lithium Chloride 230-246 glucagon Rattus norvegicus 58-63 24551104-5 2014 Although over-expression of wildtype FoxO1 in C2C12 myoblasts significantly blocked their myogenic differentiation under serum withdrawal condition, application of insulin and LiCl, an activator of Wnt signaling pathway, to these cells successfully rescued their myogenic differentiation and generated myotubes with larger diameters. Lithium Chloride 176-180 forkhead box O1 Homo sapiens 37-42 24551104-7 2014 We further found that FoxO1 directly repressed the promoter activity of myogenic genes and this repression can be relieved by insulin and LiCl treatment. Lithium Chloride 138-142 forkhead box O1 Homo sapiens 22-27 24414478-5 2014 Specifically, treatment of zebrafish embryos with LiCl inhibits GSK3 kinase function, resulting in hyperactivation of the signaling pathway and an eyeless phenotype at 1 day post fertilization. Lithium Chloride 50-54 glycogen synthase kinase 3 beta, genome duplicate a Danio rerio 64-68 24520423-9 2014 In contrast, lithium chloride (LiCl) induced accumulation of beta-catenin produced the opposite effect to that caused by beta-catenin knockdown. Lithium Chloride 13-29 catenin beta 1 Homo sapiens 61-73 24520423-9 2014 In contrast, lithium chloride (LiCl) induced accumulation of beta-catenin produced the opposite effect to that caused by beta-catenin knockdown. Lithium Chloride 13-29 catenin beta 1 Homo sapiens 121-133 24520423-9 2014 In contrast, lithium chloride (LiCl) induced accumulation of beta-catenin produced the opposite effect to that caused by beta-catenin knockdown. Lithium Chloride 31-35 catenin beta 1 Homo sapiens 61-73 24520423-9 2014 In contrast, lithium chloride (LiCl) induced accumulation of beta-catenin produced the opposite effect to that caused by beta-catenin knockdown. Lithium Chloride 31-35 catenin beta 1 Homo sapiens 121-133 24132507-7 2014 However, inhibition of GSK-3beta activity with lithium chloride treatment or knockdown of GSK-3beta expression with shRNA suppressed sodium palmitate-induced lipoapoptosis in L02 and HepG2 cells. Lithium Chloride 47-63 glycogen synthase kinase 3 beta Homo sapiens 23-32 24211867-2 2014 The present study investigated the involvement of Wnt/beta-catenin signaling in rat periapical bone destruction and whether lithium chloride (LiCl), a glycogen synthase kinase-3beta (GSK-3beta) inhibitor, promotes bone restoration. Lithium Chloride 124-140 glycogen synthase kinase 3 beta Rattus norvegicus 151-181 24211867-2 2014 The present study investigated the involvement of Wnt/beta-catenin signaling in rat periapical bone destruction and whether lithium chloride (LiCl), a glycogen synthase kinase-3beta (GSK-3beta) inhibitor, promotes bone restoration. Lithium Chloride 124-140 glycogen synthase kinase 3 beta Rattus norvegicus 183-192 24211867-7 2014 LiCl treatment also increased GSK-3beta phosphorylation and osteocalcin expression in periapical tissue. Lithium Chloride 0-4 glycogen synthase kinase 3 beta Rattus norvegicus 30-39 24211867-7 2014 LiCl treatment also increased GSK-3beta phosphorylation and osteocalcin expression in periapical tissue. Lithium Chloride 0-4 bone gamma-carboxyglutamate protein Rattus norvegicus 60-71 24442204-7 2014 We show that LiCl-induced GSK3 inhibition targets these phosphorylations and specifically decreases proliferation and colony formation of Maf-expressing MM cell lines. Lithium Chloride 13-17 MAF bZIP transcription factor Homo sapiens 138-141 24183963-6 2014 Furthermore, our data in the present study suggested that GLP-1 regulated tau phosphorylation induced by AGEs through a signaling pathway involving glycogen synthase kinase 3beta (GSK-3beta), similarly to the GSK-3beta inhibitor, lithium chloride. Lithium Chloride 230-246 glycogen synthase kinase 3 beta Rattus norvegicus 180-189 25269915-11 2014 Lithium chloride intravitreal injection increased the levels of phosphorylated Ser21/9 in GSK-3alpha/beta and decreased TUNEL-positive cells in the whole-mounted retinas. Lithium Chloride 0-16 glycogen synthase kinase 3 alpha Mus musculus 90-100 25034767-8 2014 Interestingly, the deformed cardiac phenotype was partially rescued by treatment with the GSK3beta inhibitor lithium chloride. Lithium Chloride 109-125 glycogen synthase kinase 3 beta, genome duplicate a Danio rerio 90-98 25269915-12 2014 CONCLUSION: GSK-3 kinase is closely related to retinal neuron apoptosis, and the application of the GSK-3 inhibitor lithium chloride can reduce retinal neuron apoptosis in early diabetic retinopathy. Lithium Chloride 116-132 glycogen synthase kinase 3 beta Mus musculus 12-17 25269915-12 2014 CONCLUSION: GSK-3 kinase is closely related to retinal neuron apoptosis, and the application of the GSK-3 inhibitor lithium chloride can reduce retinal neuron apoptosis in early diabetic retinopathy. Lithium Chloride 116-132 glycogen synthase kinase 3 beta Mus musculus 100-105 25002914-0 2014 Lithium chloride suppresses colorectal cancer cell survival and proliferation through ROS/GSK-3beta/NF-kappaB signaling pathway. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Homo sapiens 90-99 23685991-7 2014 Glycogen synthase kinase 3 (GSK3) inhibitor LiCl specifically enhanced both IRF3(5D) and wild type IRF3 activity, even without stimulation. Lithium Chloride 44-48 interferon regulatory factor 3 Homo sapiens 76-80 23685991-7 2014 Glycogen synthase kinase 3 (GSK3) inhibitor LiCl specifically enhanced both IRF3(5D) and wild type IRF3 activity, even without stimulation. Lithium Chloride 44-48 interferon regulatory factor 3 Homo sapiens 99-103 23685991-8 2014 Expression of constitutive active GSK3beta(S9A) represses LiCl-mediated enhancement of IRF3 transactivation activity. Lithium Chloride 58-62 glycogen synthase kinase 3 beta Homo sapiens 34-42 23685991-8 2014 Expression of constitutive active GSK3beta(S9A) represses LiCl-mediated enhancement of IRF3 transactivation activity. Lithium Chloride 58-62 interferon regulatory factor 3 Homo sapiens 87-91 24452937-17 2014 We observed a significant decrease in TNF-alpha and GFAP positivity after LiCl was administered. Lithium Chloride 74-78 tumor necrosis factor Rattus norvegicus 38-47 24452937-17 2014 We observed a significant decrease in TNF-alpha and GFAP positivity after LiCl was administered. Lithium Chloride 74-78 glial fibrillary acidic protein Rattus norvegicus 52-56 24448371-8 2014 LiCl treatment also decreased the meiotic recombination 11 (Mre11) mRNA level. Lithium Chloride 0-4 MRE11 homolog, double strand break repair nuclease Homo sapiens 34-58 24448371-8 2014 LiCl treatment also decreased the meiotic recombination 11 (Mre11) mRNA level. Lithium Chloride 0-4 MRE11 homolog, double strand break repair nuclease Homo sapiens 60-65 24448371-10 2014 Western blot analysis indicated that the beta-catenin protein level was decreased in LiCl-treated cells. Lithium Chloride 85-89 catenin beta 1 Homo sapiens 41-53 24448371-12 2014 The results demonstrated that LiCl could radiosensitize T47D cells by decreasing DNA repair, partially through Mre11 repression. Lithium Chloride 30-34 MRE11 homolog, double strand break repair nuclease Homo sapiens 111-116 24448371-13 2014 GSK-3beta/beta-catenin/Mre11 pathway might be the connection between LiCl treatment and the decreased DNA repair in T47D cells. Lithium Chloride 69-73 glycogen synthase kinase 3 beta Homo sapiens 0-9 24448371-13 2014 GSK-3beta/beta-catenin/Mre11 pathway might be the connection between LiCl treatment and the decreased DNA repair in T47D cells. Lithium Chloride 69-73 catenin beta 1 Homo sapiens 10-22 24448371-13 2014 GSK-3beta/beta-catenin/Mre11 pathway might be the connection between LiCl treatment and the decreased DNA repair in T47D cells. Lithium Chloride 69-73 MRE11 homolog, double strand break repair nuclease Homo sapiens 23-28 23904208-0 2014 Lithium chloride induces TNFalpha in mouse macrophages via MEK-ERK-dependent pathway. Lithium Chloride 0-16 tumor necrosis factor Mus musculus 25-33 23904208-0 2014 Lithium chloride induces TNFalpha in mouse macrophages via MEK-ERK-dependent pathway. Lithium Chloride 0-16 midkine Mus musculus 59-62 23904208-0 2014 Lithium chloride induces TNFalpha in mouse macrophages via MEK-ERK-dependent pathway. Lithium Chloride 0-16 mitogen-activated protein kinase 1 Mus musculus 63-66 23933549-4 2013 Large equilibrium charge and small dynamic contributions are also characteristic of stretching vibrations in the ionic diatomic molecules, NaF, NaCl, LiF and LiCl. Lithium Chloride 158-162 C-X-C motif chemokine ligand 8 Homo sapiens 139-142 25206638-6 2013 Lithium chloride could affect tau phosphorylation by regulating the interaction of tau with GSK-3beta and protein phosphatase 2A, and improve learning and memory ability of rats after transient brain ischemia. Lithium Chloride 0-16 glycogen synthase kinase 3 beta Rattus norvegicus 92-101 23720015-5 2013 Prevention of inhibition of Wnt signaling by LiCl increased cell survival upon Ad.mda-7 treatment, suggesting that Wnt signaling inhibition might play a key role in MDA-7/IL-24-mediated death of breast cancer-initiating/stem cells. Lithium Chloride 45-49 interleukin 24 Mus musculus 82-87 23720015-5 2013 Prevention of inhibition of Wnt signaling by LiCl increased cell survival upon Ad.mda-7 treatment, suggesting that Wnt signaling inhibition might play a key role in MDA-7/IL-24-mediated death of breast cancer-initiating/stem cells. Lithium Chloride 45-49 interleukin 24 Mus musculus 165-170 23720015-5 2013 Prevention of inhibition of Wnt signaling by LiCl increased cell survival upon Ad.mda-7 treatment, suggesting that Wnt signaling inhibition might play a key role in MDA-7/IL-24-mediated death of breast cancer-initiating/stem cells. Lithium Chloride 45-49 interleukin 24 Mus musculus 171-176 23812869-0 2013 Lithium chloride alleviates neurodegeneration partly by inhibiting activity of GSK3beta in a SCA3 Drosophila model. Lithium Chloride 0-16 Pk34A Drosophila melanogaster 79-87 24063812-6 2013 LiCl administration increased c-Fos expression in the hypothalamic paraventricular and supraoptic nuclei, area postrema, nucleus of the solitary tract and basolateral and central (CNA) nuclei of the amygdala. Lithium Chloride 0-4 FBJ osteosarcoma oncogene Mus musculus 30-35 23921644-6 2013 The effects of WIF1 on beta-catenin pathway could be reversed by LiCl regarding signaling pathways and effector and respondent molecules in H9c2 cells, consistent with the expression levels of c-myc, natriuretic peptide precursor type B and skeletal muscle actin alpha1. Lithium Chloride 65-69 Wnt inhibitory factor 1 Rattus norvegicus 15-19 23921644-6 2013 The effects of WIF1 on beta-catenin pathway could be reversed by LiCl regarding signaling pathways and effector and respondent molecules in H9c2 cells, consistent with the expression levels of c-myc, natriuretic peptide precursor type B and skeletal muscle actin alpha1. Lithium Chloride 65-69 catenin beta 1 Rattus norvegicus 23-35 24129564-7 2013 Ectopic beta1Pix expression enhanced LiCl-induced beta-catenin transcriptional activity. Lithium Chloride 37-41 catenin beta 1 Homo sapiens 50-62 23921644-6 2013 The effects of WIF1 on beta-catenin pathway could be reversed by LiCl regarding signaling pathways and effector and respondent molecules in H9c2 cells, consistent with the expression levels of c-myc, natriuretic peptide precursor type B and skeletal muscle actin alpha1. Lithium Chloride 65-69 natriuretic peptide B Rattus norvegicus 200-236 24129564-5 2013 In human colon cancer cells, activation of beta-catenin signaling with LiCl decreased beta1Pix/beta-catenin association in the cytosol and increased nuclear binding of beta-catenin to beta1Pix. Lithium Chloride 71-75 catenin beta 1 Homo sapiens 43-55 24129564-5 2013 In human colon cancer cells, activation of beta-catenin signaling with LiCl decreased beta1Pix/beta-catenin association in the cytosol and increased nuclear binding of beta-catenin to beta1Pix. Lithium Chloride 71-75 catenin beta 1 Homo sapiens 95-107 24129564-8 2013 Conversely, siRNA knockdown of beta1Pix attenuated both LiCl-induced beta-catenin transcriptional activity and colon cancer cell proliferation. Lithium Chloride 56-60 catenin beta 1 Homo sapiens 69-81 24129564-5 2013 In human colon cancer cells, activation of beta-catenin signaling with LiCl decreased beta1Pix/beta-catenin association in the cytosol and increased nuclear binding of beta-catenin to beta1Pix. Lithium Chloride 71-75 catenin beta 1 Homo sapiens 95-107 24260231-7 2013 GSK3 inhibitors, including LiCl and SB216763, restored the sustained Chk1 activation and mitigated apoptosis in cells treated with etoposide and the inhibitors for aberrant kinases, PI3K, or Akt. Lithium Chloride 27-31 checkpoint kinase 1 Homo sapiens 69-73 24260231-7 2013 GSK3 inhibitors, including LiCl and SB216763, restored the sustained Chk1 activation and mitigated apoptosis in cells treated with etoposide and the inhibitors for aberrant kinases, PI3K, or Akt. Lithium Chloride 27-31 AKT serine/threonine kinase 1 Homo sapiens 191-194 24130179-10 2013 Furthermore, intraperitoneal injection of LiCl, a Wnt signaling activator, increased c-Kit(+)/Tie-2(+) cells in the peripheral blood of normal mice. Lithium Chloride 42-46 TEK receptor tyrosine kinase Mus musculus 94-99 24130179-10 2013 Furthermore, intraperitoneal injection of LiCl, a Wnt signaling activator, increased c-Kit(+)/Tie-2(+) cells in the peripheral blood of normal mice. Lithium Chloride 42-46 KIT proto-oncogene receptor tyrosine kinase Mus musculus 85-90 24260576-9 2013 Furthermore, we show that alterations in healing in Cx43 deficient fractures can be rescued by inhibiting GSK-3beta activity using Lithium Chloride (LiCl). Lithium Chloride 131-147 gap junction protein, alpha 1 Mus musculus 52-56 24260576-9 2013 Furthermore, we show that alterations in healing in Cx43 deficient fractures can be rescued by inhibiting GSK-3beta activity using Lithium Chloride (LiCl). Lithium Chloride 131-147 glycogen synthase kinase 3 beta Mus musculus 106-115 24260576-9 2013 Furthermore, we show that alterations in healing in Cx43 deficient fractures can be rescued by inhibiting GSK-3beta activity using Lithium Chloride (LiCl). Lithium Chloride 149-153 gap junction protein, alpha 1 Mus musculus 52-56 24260576-9 2013 Furthermore, we show that alterations in healing in Cx43 deficient fractures can be rescued by inhibiting GSK-3beta activity using Lithium Chloride (LiCl). Lithium Chloride 149-153 glycogen synthase kinase 3 beta Mus musculus 106-115 24260576-10 2013 Treatment of Cx43 deficient mice with LiCl restores both normal bone formation and mechanical properties relative to LiCl treated WT fractures. Lithium Chloride 38-42 gap junction protein, alpha 1 Mus musculus 13-17 25206585-5 2013 The level of active Caspase-3 and the ratio of Bax/Bcl-2 in hippocampal neurons treated with TLR4 antibody or the GSK-3beta inhibitor, LiCl, creased before intervention with lipopolysaccharide, but increased after treatment with the AKT hibitor, LY294002. Lithium Chloride 135-139 caspase 3 Homo sapiens 20-29 23988651-0 2013 Dendritic cells from the elderly display an intrinsic defect in the production of IL-10 in response to lithium chloride. Lithium Chloride 103-119 interleukin 10 Homo sapiens 82-87 23988651-6 2013 The effect of Lithium Chloride (LiCl) was compared on the response of TLR4 agonist, LPS and TLR2 agonist, PAM3CSK4 stimulated aged and young DCs. Lithium Chloride 14-30 toll like receptor 4 Homo sapiens 70-74 23988651-6 2013 The effect of Lithium Chloride (LiCl) was compared on the response of TLR4 agonist, LPS and TLR2 agonist, PAM3CSK4 stimulated aged and young DCs. Lithium Chloride 14-30 toll like receptor 2 Homo sapiens 92-96 23988651-6 2013 The effect of Lithium Chloride (LiCl) was compared on the response of TLR4 agonist, LPS and TLR2 agonist, PAM3CSK4 stimulated aged and young DCs. Lithium Chloride 32-36 toll like receptor 4 Homo sapiens 70-74 23988651-6 2013 The effect of Lithium Chloride (LiCl) was compared on the response of TLR4 agonist, LPS and TLR2 agonist, PAM3CSK4 stimulated aged and young DCs. Lithium Chloride 32-36 toll like receptor 2 Homo sapiens 92-96 23988651-7 2013 LiCl enhanced the production of IL-10 in LPS stimulated young DCs. Lithium Chloride 0-4 interleukin 10 Homo sapiens 32-37 23988651-9 2013 In contrast, in aged DCs, LiCl reduced the secretion of TNF-alpha and IL-6 in LPS stimulated DCs but did not increase IL-10. Lithium Chloride 26-30 tumor necrosis factor Homo sapiens 56-65 23988651-9 2013 In contrast, in aged DCs, LiCl reduced the secretion of TNF-alpha and IL-6 in LPS stimulated DCs but did not increase IL-10. Lithium Chloride 26-30 interleukin 6 Homo sapiens 70-74 23988651-11 2013 LiCl treated DCs also displayed differences at the level of CD4 T cell priming and polarization. Lithium Chloride 0-4 CD4 molecule Homo sapiens 60-63 23979838-10 2013 Finally, we found that administration of lithium chloride, a well-known GSK-3beta inhibitor, resulted in decreased levels of phosphorylated tau in DJ-1L166P-transfected cells. Lithium Chloride 41-57 glycogen synthase kinase 3 alpha Homo sapiens 72-81 23979838-10 2013 Finally, we found that administration of lithium chloride, a well-known GSK-3beta inhibitor, resulted in decreased levels of phosphorylated tau in DJ-1L166P-transfected cells. Lithium Chloride 41-57 microtubule associated protein tau Homo sapiens 140-143 24033914-3 2013 We found that insulin/IGF1 and lithium chloride enhanced IL-17-induced expression of C-X-C motif ligand 1 (Cxcl1) and C-C motif ligand 20 (Ccl20) in the Gsk3b(+/+) , but not in Gsk3b(-/-) mouse embryonic fibroblast (MEF) cells. Lithium Chloride 31-47 interleukin 17A Mus musculus 57-62 24033914-3 2013 We found that insulin/IGF1 and lithium chloride enhanced IL-17-induced expression of C-X-C motif ligand 1 (Cxcl1) and C-C motif ligand 20 (Ccl20) in the Gsk3b(+/+) , but not in Gsk3b(-/-) mouse embryonic fibroblast (MEF) cells. Lithium Chloride 31-47 chemokine (C-X-C motif) ligand 1 Mus musculus 85-105 24033914-3 2013 We found that insulin/IGF1 and lithium chloride enhanced IL-17-induced expression of C-X-C motif ligand 1 (Cxcl1) and C-C motif ligand 20 (Ccl20) in the Gsk3b(+/+) , but not in Gsk3b(-/-) mouse embryonic fibroblast (MEF) cells. Lithium Chloride 31-47 chemokine (C-X-C motif) ligand 1 Mus musculus 107-112 24033914-3 2013 We found that insulin/IGF1 and lithium chloride enhanced IL-17-induced expression of C-X-C motif ligand 1 (Cxcl1) and C-C motif ligand 20 (Ccl20) in the Gsk3b(+/+) , but not in Gsk3b(-/-) mouse embryonic fibroblast (MEF) cells. Lithium Chloride 31-47 chemokine (C-C motif) ligand 20 Mus musculus 118-137 24033914-3 2013 We found that insulin/IGF1 and lithium chloride enhanced IL-17-induced expression of C-X-C motif ligand 1 (Cxcl1) and C-C motif ligand 20 (Ccl20) in the Gsk3b(+/+) , but not in Gsk3b(-/-) mouse embryonic fibroblast (MEF) cells. Lithium Chloride 31-47 chemokine (C-C motif) ligand 20 Mus musculus 139-144 24033914-3 2013 We found that insulin/IGF1 and lithium chloride enhanced IL-17-induced expression of C-X-C motif ligand 1 (Cxcl1) and C-C motif ligand 20 (Ccl20) in the Gsk3b(+/+) , but not in Gsk3b(-/-) mouse embryonic fibroblast (MEF) cells. Lithium Chloride 31-47 glycogen synthase kinase 3 beta Mus musculus 153-158 24033914-3 2013 We found that insulin/IGF1 and lithium chloride enhanced IL-17-induced expression of C-X-C motif ligand 1 (Cxcl1) and C-C motif ligand 20 (Ccl20) in the Gsk3b(+/+) , but not in Gsk3b(-/-) mouse embryonic fibroblast (MEF) cells. Lithium Chloride 31-47 glycogen synthase kinase 3 beta Mus musculus 177-182 23872260-7 2013 Blocking GSK3beta/beta-catenin pathway was required for wogonin-induced proliferation inhibition and terminal differentiation by using canonical activator lithium chloride (LiCl) and inhibitor dickkopf-1 (Dkk1). Lithium Chloride 155-171 glycogen synthase kinase 3 beta Homo sapiens 9-17 23872260-7 2013 Blocking GSK3beta/beta-catenin pathway was required for wogonin-induced proliferation inhibition and terminal differentiation by using canonical activator lithium chloride (LiCl) and inhibitor dickkopf-1 (Dkk1). Lithium Chloride 155-171 catenin beta 1 Homo sapiens 18-30 23872260-7 2013 Blocking GSK3beta/beta-catenin pathway was required for wogonin-induced proliferation inhibition and terminal differentiation by using canonical activator lithium chloride (LiCl) and inhibitor dickkopf-1 (Dkk1). Lithium Chloride 173-177 glycogen synthase kinase 3 beta Homo sapiens 9-17 23872260-7 2013 Blocking GSK3beta/beta-catenin pathway was required for wogonin-induced proliferation inhibition and terminal differentiation by using canonical activator lithium chloride (LiCl) and inhibitor dickkopf-1 (Dkk1). Lithium Chloride 173-177 catenin beta 1 Homo sapiens 18-30 24043902-3 2013 In this study, we show that lithium chloride attenuates LPS-, polyinosinic-polycytidylic acid-, and Sendai virus-induced IFN-beta production and IFN regulatory factor 3 activation in macrophages in a glycogen synthase kinase-3beta-independent manner. Lithium Chloride 28-44 interferon beta 1, fibroblast Mus musculus 121-129 24043902-3 2013 In this study, we show that lithium chloride attenuates LPS-, polyinosinic-polycytidylic acid-, and Sendai virus-induced IFN-beta production and IFN regulatory factor 3 activation in macrophages in a glycogen synthase kinase-3beta-independent manner. Lithium Chloride 28-44 glycogen synthase kinase 3 beta Mus musculus 200-230 23954827-6 2013 After treatment with lithium chloride (LiCl), the protein expression of phospho GSK-3beta and beta-catenin was increased in each group compared to the corresponding group without LiCl. Lithium Chloride 21-37 glycogen synthase kinase 3 beta Homo sapiens 80-89 23871716-0 2013 Inhibition of glycogen synthase kinase-3beta by lithium chloride suppresses 6-hydroxydopamine-induced inflammatory response in primary cultured astrocytes. Lithium Chloride 48-64 glycogen synthase kinase 3 beta Homo sapiens 14-44 23871716-9 2013 Besides, GSK-3beta inhibitor LiCl and SB415286 inhibited the GSK-3beta/NF-kappaB signaling pathway, leading to the reduction of proinflammatory molecules in 6-OHDA-activated astrocytes. Lithium Chloride 29-33 glycogen synthase kinase 3 beta Homo sapiens 9-18 23871716-9 2013 Besides, GSK-3beta inhibitor LiCl and SB415286 inhibited the GSK-3beta/NF-kappaB signaling pathway, leading to the reduction of proinflammatory molecules in 6-OHDA-activated astrocytes. Lithium Chloride 29-33 glycogen synthase kinase 3 beta Homo sapiens 61-70 23871716-10 2013 These results confirmed that GSK-3beta inhibitor LiCl and SB415286 provide protection against neuroinflammation in 6-OHDA-treated astrocytes. Lithium Chloride 49-53 glycogen synthase kinase 3 beta Homo sapiens 29-38 24025791-0 2013 RNAi screening identifies GSK3beta as a regulator of DRP1 and the neuroprotection of lithium chloride against elevated pressure involved in downregulation of DRP1. Lithium Chloride 85-101 glycogen synthase kinase 3 beta Homo sapiens 26-34 24025791-0 2013 RNAi screening identifies GSK3beta as a regulator of DRP1 and the neuroprotection of lithium chloride against elevated pressure involved in downregulation of DRP1. Lithium Chloride 85-101 collapsin response mediator protein 1 Homo sapiens 158-162 24025791-6 2013 Use of the pharmacological inhibitor of GSK3beta inhibitor, lithium chloride (LiCl), confirmed this result. Lithium Chloride 60-76 glycogen synthase kinase 3 beta Homo sapiens 40-48 24025791-6 2013 Use of the pharmacological inhibitor of GSK3beta inhibitor, lithium chloride (LiCl), confirmed this result. Lithium Chloride 78-82 glycogen synthase kinase 3 beta Homo sapiens 40-48 24025791-7 2013 Furthermore, we demonstrated that one of the mechanisms of lithium chloride neuroprotection might be via inhibition of mitochondrial fission through downregulation of Drp1. Lithium Chloride 59-75 collapsin response mediator protein 1 Homo sapiens 167-171 24043902-4 2013 The ability of the lithium to inhibit IFN-beta production was confirmed in vivo, as mice treated with lithium chloride exhibited decreased levels of IFN-beta upon Sendai virus infection. Lithium Chloride 102-118 interferon beta 1, fibroblast Mus musculus 38-46 24043902-4 2013 The ability of the lithium to inhibit IFN-beta production was confirmed in vivo, as mice treated with lithium chloride exhibited decreased levels of IFN-beta upon Sendai virus infection. Lithium Chloride 102-118 interferon beta 1, fibroblast Mus musculus 149-157 25206585-5 2013 The level of active Caspase-3 and the ratio of Bax/Bcl-2 in hippocampal neurons treated with TLR4 antibody or the GSK-3beta inhibitor, LiCl, creased before intervention with lipopolysaccharide, but increased after treatment with the AKT hibitor, LY294002. Lithium Chloride 135-139 BCL2 associated X, apoptosis regulator Homo sapiens 47-50 25206585-5 2013 The level of active Caspase-3 and the ratio of Bax/Bcl-2 in hippocampal neurons treated with TLR4 antibody or the GSK-3beta inhibitor, LiCl, creased before intervention with lipopolysaccharide, but increased after treatment with the AKT hibitor, LY294002. Lithium Chloride 135-139 BCL2 apoptosis regulator Homo sapiens 51-56 25206585-5 2013 The level of active Caspase-3 and the ratio of Bax/Bcl-2 in hippocampal neurons treated with TLR4 antibody or the GSK-3beta inhibitor, LiCl, creased before intervention with lipopolysaccharide, but increased after treatment with the AKT hibitor, LY294002. Lithium Chloride 135-139 glycogen synthase kinase 3 beta Homo sapiens 114-123 25206585-5 2013 The level of active Caspase-3 and the ratio of Bax/Bcl-2 in hippocampal neurons treated with TLR4 antibody or the GSK-3beta inhibitor, LiCl, creased before intervention with lipopolysaccharide, but increased after treatment with the AKT hibitor, LY294002. Lithium Chloride 135-139 AKT serine/threonine kinase 1 Homo sapiens 233-236 23954827-6 2013 After treatment with lithium chloride (LiCl), the protein expression of phospho GSK-3beta and beta-catenin was increased in each group compared to the corresponding group without LiCl. Lithium Chloride 21-37 catenin beta 1 Homo sapiens 94-106 23954827-6 2013 After treatment with lithium chloride (LiCl), the protein expression of phospho GSK-3beta and beta-catenin was increased in each group compared to the corresponding group without LiCl. Lithium Chloride 39-43 glycogen synthase kinase 3 beta Homo sapiens 80-89 23954827-6 2013 After treatment with lithium chloride (LiCl), the protein expression of phospho GSK-3beta and beta-catenin was increased in each group compared to the corresponding group without LiCl. Lithium Chloride 39-43 catenin beta 1 Homo sapiens 94-106 23954827-6 2013 After treatment with lithium chloride (LiCl), the protein expression of phospho GSK-3beta and beta-catenin was increased in each group compared to the corresponding group without LiCl. Lithium Chloride 179-183 glycogen synthase kinase 3 beta Homo sapiens 80-89 23954827-6 2013 After treatment with lithium chloride (LiCl), the protein expression of phospho GSK-3beta and beta-catenin was increased in each group compared to the corresponding group without LiCl. Lithium Chloride 179-183 catenin beta 1 Homo sapiens 94-106 24198747-12 2013 Finally, we determined that HT29/C1 cells treated with LiCl (beta-catenin activator) induced IL-8 secretion in a dose-dependent and time-dependent manner. Lithium Chloride 55-59 catenin beta 1 Homo sapiens 61-73 24091664-0 2013 Lithium chloride attenuates cell death in oculopharyngeal muscular dystrophy by perturbing Wnt/beta-catenin pathway. Lithium Chloride 0-16 catenin beta 1 Homo sapiens 95-107 24091664-7 2013 Here, we explored a pharmacological manipulation of a Wnt signaling pathway using lithium chloride (LiCl), a GSK-3beta inhibitor, and observed the enhanced expression of beta-catenin protein as well as the decreased cell death normally observed in an OPMD cell model of murine myoblast (C2C12) expressing the expanded and pathogenic form of the expPABPN1. Lithium Chloride 82-98 glycogen synthase kinase 3 beta Mus musculus 109-118 24091664-7 2013 Here, we explored a pharmacological manipulation of a Wnt signaling pathway using lithium chloride (LiCl), a GSK-3beta inhibitor, and observed the enhanced expression of beta-catenin protein as well as the decreased cell death normally observed in an OPMD cell model of murine myoblast (C2C12) expressing the expanded and pathogenic form of the expPABPN1. Lithium Chloride 82-98 catenin (cadherin associated protein), beta 1 Mus musculus 170-182 24091664-7 2013 Here, we explored a pharmacological manipulation of a Wnt signaling pathway using lithium chloride (LiCl), a GSK-3beta inhibitor, and observed the enhanced expression of beta-catenin protein as well as the decreased cell death normally observed in an OPMD cell model of murine myoblast (C2C12) expressing the expanded and pathogenic form of the expPABPN1. Lithium Chloride 100-104 glycogen synthase kinase 3 beta Mus musculus 109-118 24091664-7 2013 Here, we explored a pharmacological manipulation of a Wnt signaling pathway using lithium chloride (LiCl), a GSK-3beta inhibitor, and observed the enhanced expression of beta-catenin protein as well as the decreased cell death normally observed in an OPMD cell model of murine myoblast (C2C12) expressing the expanded and pathogenic form of the expPABPN1. Lithium Chloride 100-104 catenin (cadherin associated protein), beta 1 Mus musculus 170-182 24091664-9 2013 A similar effect on beta-catenin was also observed when lymphoblastoid cells lines (LCLs) derived from OPMD patients were treated with LiCl. Lithium Chloride 135-139 catenin beta 1 Homo sapiens 20-32 23889598-5 2013 KEY RESULTS: In rats, THCA (0.05 and/or 0.5 mg kg(-1) ) suppressed LiCl-induced conditioned gaping to a flavour and context; the latter effect blocked by the CB1 receptor antagonist, SR, but not by the 5-hydroxytryptamine-1A receptor antagonist, WAY100635. Lithium Chloride 67-71 cannabinoid receptor 1 Rattus norvegicus 158-161 24091675-6 2013 We further found that the Wnt/beta-catenin pathway is involved in Dex-induced osteoporosis and C/EBPalpha promoter methylation, and its activation by LiCl rescues the effect of Dex on C/EBPalpha promoter methylation and osteoblast/adipocyte balance. Lithium Chloride 150-154 catenin (cadherin associated protein), beta 1 Mus musculus 30-42 24091675-6 2013 We further found that the Wnt/beta-catenin pathway is involved in Dex-induced osteoporosis and C/EBPalpha promoter methylation, and its activation by LiCl rescues the effect of Dex on C/EBPalpha promoter methylation and osteoblast/adipocyte balance. Lithium Chloride 150-154 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 184-194 23689589-8 2013 LiCl (a GSK3beta inhibitor)-treated cells also showed increased expression of Snail, with a reduced adipogenic potential. Lithium Chloride 0-4 glycogen synthase kinase 3 beta Mus musculus 8-16 23689589-8 2013 LiCl (a GSK3beta inhibitor)-treated cells also showed increased expression of Snail, with a reduced adipogenic potential. Lithium Chloride 0-4 snail family zinc finger 1 Mus musculus 78-83 24198747-12 2013 Finally, we determined that HT29/C1 cells treated with LiCl (beta-catenin activator) induced IL-8 secretion in a dose-dependent and time-dependent manner. Lithium Chloride 55-59 C-X-C motif chemokine ligand 8 Homo sapiens 93-97 23900432-9 2013 When 4T1 cells were treated with recombinant Wnt3a or LiCl along with quercetin, both stimulators for the Wnt/beta-catenin signaling pathway were able to restore the suppressed cell viability by quercetin. Lithium Chloride 54-58 catenin (cadherin associated protein), beta 1 Mus musculus 110-122 23941783-5 2013 Inhibition of GSK3beta by either lithium chloride (LiCl) or specific GSK3beta inhibitor VIII showed cytostatic and cytotoxic effects on multiple endometrial cancer cell lines, with little effect on the immortalized normal endometrial cell line. Lithium Chloride 33-49 glycogen synthase kinase 3 beta Homo sapiens 14-22 24069197-9 2013 In addition, LiCl or atorvastatin could reduce MMP-2/9 activity in the aortic arch but not in the ligated area of the CCA. Lithium Chloride 13-17 matrix metallopeptidase 2 Mus musculus 47-52 23701903-4 2013 We found that MCLR could suppress the induction of LTP in rat hippocampus, whereas simultaneous inhibition of glycogen synthase kinase-3beta (GSK-3beta) by LiCl or SB216763 attenuated the LTP impairments by MCLR. Lithium Chloride 156-160 glycogen synthase kinase 3 beta Rattus norvegicus 110-140 23701903-4 2013 We found that MCLR could suppress the induction of LTP in rat hippocampus, whereas simultaneous inhibition of glycogen synthase kinase-3beta (GSK-3beta) by LiCl or SB216763 attenuated the LTP impairments by MCLR. Lithium Chloride 156-160 glycogen synthase kinase 3 beta Rattus norvegicus 142-151 23850563-7 2013 Remarkably, the hyperactivity of the Cdk5 conditional knockouts can be ameliorated by the administration of lithium chloride, an inhibitor of GSK3beta signaling. Lithium Chloride 108-124 cyclin-dependent kinase 5 Mus musculus 37-41 23850563-7 2013 Remarkably, the hyperactivity of the Cdk5 conditional knockouts can be ameliorated by the administration of lithium chloride, an inhibitor of GSK3beta signaling. Lithium Chloride 108-124 glycogen synthase kinase 3 beta Mus musculus 142-150 24251329-3 2013 In this study, the human cation-chloride co-transporter NKCC2 complemented the phenotype of VHC1 deletion in Saccharomyces cerevisiae and its activity controlled the growth of salt-sensitive yeast cells in the presence of high KCl, NaCl and LiCl. Lithium Chloride 241-245 solute carrier family 12 member 1 Homo sapiens 56-61 24251329-3 2013 In this study, the human cation-chloride co-transporter NKCC2 complemented the phenotype of VHC1 deletion in Saccharomyces cerevisiae and its activity controlled the growth of salt-sensitive yeast cells in the presence of high KCl, NaCl and LiCl. Lithium Chloride 241-245 Vhc1p Saccharomyces cerevisiae S288C 92-96 23964123-4 2013 Interestingly, systemic administration of LiCl in a critical time window before AgRP neuron ablation abolished the anorectic response. Lithium Chloride 42-46 agouti related neuropeptide Mus musculus 80-84 23964123-5 2013 LiCl treatment suppressed NR2B levels in the PBN and ameliorated the local Fos induction that is associated with anorexia. Lithium Chloride 0-4 glutamate receptor, ionotropic, NMDA2B (epsilon 2) Mus musculus 26-30 23964123-5 2013 LiCl treatment suppressed NR2B levels in the PBN and ameliorated the local Fos induction that is associated with anorexia. Lithium Chloride 0-4 FBJ osteosarcoma oncogene Mus musculus 75-78 23494401-5 2013 Inhibition of GSK-3beta with LiCl in Dianeal and Extraneal -treated cells dose-dependently decreased cell damage and death rate and was paralleled by higher HSF-1 activation and Hsp72 expression. Lithium Chloride 29-33 glycogen synthase kinase 3 beta Homo sapiens 14-23 23494401-5 2013 Inhibition of GSK-3beta with LiCl in Dianeal and Extraneal -treated cells dose-dependently decreased cell damage and death rate and was paralleled by higher HSF-1 activation and Hsp72 expression. Lithium Chloride 29-33 heat shock transcription factor 1 Homo sapiens 158-163 23494401-5 2013 Inhibition of GSK-3beta with LiCl in Dianeal and Extraneal -treated cells dose-dependently decreased cell damage and death rate and was paralleled by higher HSF-1 activation and Hsp72 expression. Lithium Chloride 29-33 heat shock protein family A (Hsp70) member 1A Homo sapiens 179-184 23494401-7 2013 Inhibition of GSK-3beta with LiCl ameliorated cell injury and improved HSR upon PDF exposure. Lithium Chloride 29-33 glycogen synthase kinase 3 beta Homo sapiens 14-23 23673211-12 2013 Furthermore, phosphorylation of GSK-3beta at serine 9 by LiCl and transient interference of GSK-3beta by siRNA increased beta-catenin and survivin protein expression in A549/DDP cells. Lithium Chloride 57-61 glycogen synthase kinase 3 beta Homo sapiens 32-41 23941783-5 2013 Inhibition of GSK3beta by either lithium chloride (LiCl) or specific GSK3beta inhibitor VIII showed cytostatic and cytotoxic effects on multiple endometrial cancer cell lines, with little effect on the immortalized normal endometrial cell line. Lithium Chloride 51-55 glycogen synthase kinase 3 beta Homo sapiens 14-22 23838963-5 2013 The mood-stabilizing agents lithium chloride and valproic acid, which have attenuating effects on the Akt/GSK3 pathway, also partially generalized to the discriminative stimulus effects of U-50,488H. Lithium Chloride 28-44 AKT serine/threonine kinase 1 Rattus norvegicus 102-105 23904373-7 2013 However, these changes were reversed by prophylactic LiCl, a non-selective inhibitor of GSK-3beta. Lithium Chloride 53-57 glycogen synthase kinase 3 beta Rattus norvegicus 88-97 22626030-0 2013 GSK3b-inhibitor lithium chloride enhances activation of Wnt canonical signaling and osteoblast differentiation on hydrophilic titanium surfaces. Lithium Chloride 16-32 glycogen synthase kinase 3 beta Mus musculus 0-5 22626030-2 2013 This study investigated whether stimulation of Wnt signaling by GSK3b inhibitor lithium chloride (LiCl) could affect the response of mesenchymal or osteoblastic cells growing on titanium surfaces with different topography and wettability, and improve their differentiation along the osteoblastic lineage. Lithium Chloride 80-96 glycogen synthase kinase 3 beta Mus musculus 64-69 22626030-2 2013 This study investigated whether stimulation of Wnt signaling by GSK3b inhibitor lithium chloride (LiCl) could affect the response of mesenchymal or osteoblastic cells growing on titanium surfaces with different topography and wettability, and improve their differentiation along the osteoblastic lineage. Lithium Chloride 98-102 glycogen synthase kinase 3 beta Mus musculus 64-69 22626030-7 2013 Addition of 1 mM LiCl increased levels for bone marker Osteocalcin in MC3T3 cells on modSLA surfaces. Lithium Chloride 17-21 bone gamma-carboxyglutamate protein 2 Mus musculus 55-66 23376468-5 2013 Inhibition of GSK3beta by either phosphorylation by AKT or lithium chloride resulted in activation of pyruvate dehydrogenase, i.e., a decrease in its phosphorylated form. Lithium Chloride 59-75 glycogen synthase kinase 3 beta Homo sapiens 14-22 23846217-11 2013 Pretreatment of LiCL, an inhibitor of GSK3beta, could significantly ameliorate apoptosis induced by celastrol. Lithium Chloride 16-20 glycogen synthase kinase 3 beta Homo sapiens 38-46 23571490-3 2013 One of these mutants, rsa3-1, is hypersensitive to NaCl and LiCl but not to CsCl or to general osmotic stress. Lithium Chloride 60-64 Exostosin family protein Arabidopsis thaliana 22-26 23619006-8 2013 Interestingly the application of lithium chloride, a GSK-3beta inhibitor, reversed the suppressive effect of TCDD on beta-catenin in PC12 cells and primary cortical neurons restoring cell viability and protecting cells from apoptosis as compared to untreated controls. Lithium Chloride 33-49 glycogen synthase kinase 3 beta Rattus norvegicus 53-62 23619006-8 2013 Interestingly the application of lithium chloride, a GSK-3beta inhibitor, reversed the suppressive effect of TCDD on beta-catenin in PC12 cells and primary cortical neurons restoring cell viability and protecting cells from apoptosis as compared to untreated controls. Lithium Chloride 33-49 catenin beta 1 Rattus norvegicus 117-129 23815230-4 2013 Using the scratch wound assay and a modified Boyden chamber, we found that LY294002, a selective phosphatidylinositol 3-kinase inhibitor, and LiCl, a selective GSK3beta inhibitor, abolished LGI3-induced cell migration. Lithium Chloride 142-146 glycogen synthase kinase 3 beta Homo sapiens 160-168 23815230-4 2013 Using the scratch wound assay and a modified Boyden chamber, we found that LY294002, a selective phosphatidylinositol 3-kinase inhibitor, and LiCl, a selective GSK3beta inhibitor, abolished LGI3-induced cell migration. Lithium Chloride 142-146 leucine rich repeat LGI family member 3 Homo sapiens 190-194 22996420-9 2013 The G185R cells treated with lithium chloride (LiCl; a Wnt signalling activator) displayed higher BiP expression but similar cell viability compared with THP1 and HNEwt/THP1 cells treated with LiCl. Lithium Chloride 29-45 heat shock protein 5 Mus musculus 98-101 22996420-9 2013 The G185R cells treated with lithium chloride (LiCl; a Wnt signalling activator) displayed higher BiP expression but similar cell viability compared with THP1 and HNEwt/THP1 cells treated with LiCl. Lithium Chloride 47-51 heat shock protein 5 Mus musculus 98-101 22996420-9 2013 The G185R cells treated with lithium chloride (LiCl; a Wnt signalling activator) displayed higher BiP expression but similar cell viability compared with THP1 and HNEwt/THP1 cells treated with LiCl. Lithium Chloride 193-197 GLI family zinc finger 2 Homo sapiens 169-173 23154940-4 2013 The levels of surfactant protein (SP) C, SPB, and SPD, the specific markers of AT II cells, correspondingly increased in mMSCs when Wnt3a or LiCl was added to the co-culture system to activate wnt/beta-catenin signaling. Lithium Chloride 141-145 sparse coat Mus musculus 14-39 23154940-4 2013 The levels of surfactant protein (SP) C, SPB, and SPD, the specific markers of AT II cells, correspondingly increased in mMSCs when Wnt3a or LiCl was added to the co-culture system to activate wnt/beta-catenin signaling. Lithium Chloride 141-145 surfactant associated protein B Mus musculus 41-44 23154940-4 2013 The levels of surfactant protein (SP) C, SPB, and SPD, the specific markers of AT II cells, correspondingly increased in mMSCs when Wnt3a or LiCl was added to the co-culture system to activate wnt/beta-catenin signaling. Lithium Chloride 141-145 catenin (cadherin associated protein), beta 1 Mus musculus 197-209 23239117-5 2013 Depletion of Akt1 and Akt2 resulted in a disconnection of APC/EB1 and a decrease in bone-resorbing activity along with reduced sealing zone formation, both of which were recovered upon the addition of LiCl, a glycogen synthase kinase-3beta (GSK-3beta) inhibitor. Lithium Chloride 201-205 thymoma viral proto-oncogene 1 Mus musculus 13-17 23239117-5 2013 Depletion of Akt1 and Akt2 resulted in a disconnection of APC/EB1 and a decrease in bone-resorbing activity along with reduced sealing zone formation, both of which were recovered upon the addition of LiCl, a glycogen synthase kinase-3beta (GSK-3beta) inhibitor. Lithium Chloride 201-205 thymoma viral proto-oncogene 2 Mus musculus 22-26 23239117-5 2013 Depletion of Akt1 and Akt2 resulted in a disconnection of APC/EB1 and a decrease in bone-resorbing activity along with reduced sealing zone formation, both of which were recovered upon the addition of LiCl, a glycogen synthase kinase-3beta (GSK-3beta) inhibitor. Lithium Chloride 201-205 glycogen synthase kinase 3 beta Mus musculus 241-250