PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 12518436-0 2002 [A critical role of the CDM family molecule DOCK2 in lymphocyte migration]. Chlorphenamidine 24-27 dedicator of cytokinesis 2 Homo sapiens 44-49 9537832-5 1998 This was demonstrated by showing that the inhibitory effect of PMA on oligodendrocyte differentiation could be completely abolished by a combined action of insulin, triiodothyronine (T3), hydrocortisone and other components of a chemically defined medium (CDM). Chlorphenamidine 256-259 insulin Homo sapiens 156-163 1658985-2 1991 The present study examined the effects of CDF on adrenocortical and pituitary prolactin secretion, which are known to involve central adrenergic receptors. Chlorphenamidine 42-45 prolactin Rattus norvegicus 78-87 9209423-5 1997 In CDM, in the absence of exogenous factors, ES cells form neuroectoderm, upregulating the early neural marker Pax-6. Chlorphenamidine 3-6 paired box 6 Homo sapiens 111-116 8436603-3 1993 Hepatocytes were maintained in culture for 20 days in CDM containing DMSO and EGF, insulin, and glucagon. Chlorphenamidine 54-57 epidermal growth factor like 1 Rattus norvegicus 78-81 8841430-6 1996 The addition of effectors such as NGF (10(-11) M), EGF (10(-10) M), PDGF (10(-10) M), and insulin (10(-7) M) to cells in CDM prevents the surface mediated death. Chlorphenamidine 121-124 epidermal growth factor Homo sapiens 51-54 8907250-4 1996 In contrast, on day 21 both MAO A and MAO B activities were markedly higher in astrocytes subcultured in CDM compared with cells maintained in serum-supplemented medium. Chlorphenamidine 105-108 monoamine oxidase A Rattus norvegicus 28-33 8907250-4 1996 In contrast, on day 21 both MAO A and MAO B activities were markedly higher in astrocytes subcultured in CDM compared with cells maintained in serum-supplemented medium. Chlorphenamidine 105-108 monoamine oxidase B Rattus norvegicus 38-43 8907250-6 1996 Consistently, the recovery of MAO A and MAO B activity after irreversible enzyme inhibition by clorgyline and deprenyl was faster in CDM than in FBS-supplemented medium, indicating enhanced enzyme synthesis under serum-free condition. Chlorphenamidine 133-136 monoamine oxidase A Rattus norvegicus 30-35 8907250-6 1996 Consistently, the recovery of MAO A and MAO B activity after irreversible enzyme inhibition by clorgyline and deprenyl was faster in CDM than in FBS-supplemented medium, indicating enhanced enzyme synthesis under serum-free condition. Chlorphenamidine 133-136 monoamine oxidase B Rattus norvegicus 40-45 8907250-8 1996 The effect of CDM on astrocyte MAO does not appear to be due to selection of a subpopulation of cells, but rather linked to a morphological change (differentiation) with increased synthesis of both MAO isoenzymes. Chlorphenamidine 14-17 monoamine oxidase A Rattus norvegicus 31-34 8907250-8 1996 The effect of CDM on astrocyte MAO does not appear to be due to selection of a subpopulation of cells, but rather linked to a morphological change (differentiation) with increased synthesis of both MAO isoenzymes. Chlorphenamidine 14-17 monoamine oxidase A Rattus norvegicus 198-201 7642568-4 1995 The CDM expressed in CHO-K1 cells formed the covalent trimers, but not the noncovalent dodecamers, typical of native SP-D. Chlorphenamidine 4-7 surfactant protein D Rattus norvegicus 117-121 7812593-8 1994 All investigated groups of CDM had significantly higher sums of blood sugar and insulin levels during the OGTT (P < 0.01), as compared with the control group (n = 31). Chlorphenamidine 27-30 insulin Homo sapiens 80-87 1336014-6 1992 Expression of the LDL receptor and HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase genes was comparable in Hep G2 cells cultured in CDM and serum-containing medium. Chlorphenamidine 142-145 low density lipoprotein receptor Homo sapiens 18-30 1336014-6 1992 Expression of the LDL receptor and HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase genes was comparable in Hep G2 cells cultured in CDM and serum-containing medium. Chlorphenamidine 142-145 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 44-92 1559343-9 1992 Addition of 100 nM epidermal growth factor (EGF) or 10 microM insulin to CDM supplemented with low levels of adult human serum (0.5%) stimulated significantly higher numbers of labeled nuclei compared with paired corneas cultured with 0.5% adult human serum. Chlorphenamidine 73-76 insulin Homo sapiens 62-69 1852718-10 1991 Since CDF has been found to elevate serum corticosterone (CORT), 10 mg CORT/rat were given at different times prior to the surge. Chlorphenamidine 6-9 cortistatin Rattus norvegicus 58-62 1658985-9 1991 Dexamethasone was able to block the CDF-induced rise in CORT and significantly suppressed PRL levels in both saline- and CDF-treated groups. Chlorphenamidine 121-124 prolactin Rattus norvegicus 90-93 34939754-10 2021 Expression of INSULIN and GLUT-2 genes (P<0.01 and P<0.05, respectively), insulin secretion in response to glucose (P<0.01), and percentage of NG-positive cells (P<0.05) in the 3MA-exposed cells were considerably lower than the cells treated with CDM. Chlorphenamidine 247-250 insulin Homo sapiens 14-21 34939754-10 2021 Expression of INSULIN and GLUT-2 genes (P<0.01 and P<0.05, respectively), insulin secretion in response to glucose (P<0.01), and percentage of NG-positive cells (P<0.05) in the 3MA-exposed cells were considerably lower than the cells treated with CDM. Chlorphenamidine 247-250 solute carrier family 2 member 2 Homo sapiens 26-32 34939754-10 2021 Expression of INSULIN and GLUT-2 genes (P<0.01 and P<0.05, respectively), insulin secretion in response to glucose (P<0.01), and percentage of NG-positive cells (P<0.05) in the 3MA-exposed cells were considerably lower than the cells treated with CDM. Chlorphenamidine 247-250 insulin Homo sapiens 74-81 7028591-5 1981 A high dose of insulin produced a lower uptake in patients with JODM (p less than 0.01), AODM (p less than 0.01) and CDM (p less than 0.05) when compared with controls. Chlorphenamidine 117-120 insulin Homo sapiens 15-22 35458727-5 2022 The resulting CDM efficiently promoted the reactive oxygen species (ROS) under visible light irradiation and thereby induced caspase-3 overexpression in pacreatic cancers, which subsequently released the MMAE from the system. Chlorphenamidine 14-17 caspase 3 Homo sapiens 125-134 3447593-3 1987 By the use of the BXD series of recombinant inbred strains and by crosses between C57BL and CSB, it was possible to map the gene to the distal part of chromosome 3 by demonstration of linkage to a gene for cadmium resistance, cdm, as well as to the Adh-3 locus. Chlorphenamidine 226-229 excision repair cross-complementing rodent repair deficiency, complementation group 6 Mus musculus 92-95 3034195-1 1987 Chlordimeform (N"(4-chloro-o-tolyl)-N, N-dimethylformamidine; CDM) is a formamidine insecticide acaricide whose major active metabolite is its N-monomethyl analog, desmethylchlordimeform, (DCDM). Chlorphenamidine 0-13 cadmium resistance Mus musculus 62-65 3034195-1 1987 Chlordimeform (N"(4-chloro-o-tolyl)-N, N-dimethylformamidine; CDM) is a formamidine insecticide acaricide whose major active metabolite is its N-monomethyl analog, desmethylchlordimeform, (DCDM). Chlorphenamidine 15-60 cadmium resistance Mus musculus 62-65 3083168-5 1986 This increase in the tyramine isomers is consistent with the ability of chlordimeform and its metabolite, demethylchlordimeform, to inhibit monoamine oxidase (MAO). Chlorphenamidine 72-85 monoamine oxidase A Rattus norvegicus 140-157 3083168-5 1986 This increase in the tyramine isomers is consistent with the ability of chlordimeform and its metabolite, demethylchlordimeform, to inhibit monoamine oxidase (MAO). Chlorphenamidine 72-85 monoamine oxidase A Rattus norvegicus 159-162 4058679-1 1985 Chlordimeform (CDM), a formamidine insecticide and monoamine oxidase (MAO) inhibitor, has recently been shown to produce large changes in visual evoked potentials of hooded rats (Boyes and Dyer, 1984a). Chlorphenamidine 0-13 monoamine oxidase A Rattus norvegicus 70-73 4058679-1 1985 Chlordimeform (CDM), a formamidine insecticide and monoamine oxidase (MAO) inhibitor, has recently been shown to produce large changes in visual evoked potentials of hooded rats (Boyes and Dyer, 1984a). Chlorphenamidine 15-18 monoamine oxidase A Rattus norvegicus 70-73 4058679-3 1985 In the first, the degree of inhibition of MAO in the brains of rats treated with chlordimeform (1.0-100 mg/kg, i.p.) Chlorphenamidine 81-94 monoamine oxidase A Rattus norvegicus 42-45 4058679-10 1985 These results confirm that chlordimeform is a MAO inhibitor at doses which produce behavioral and electrophysiological changes, but demonstrate further that the changes in visual evoked potentials produced by chlordimeform are not a direct result of the inhibition of MAO. Chlorphenamidine 27-40 monoamine oxidase A Rattus norvegicus 46-49 7028591-6 1981 However, when lower doses of insulin were used, 2 out 5 cases of JODM and 4 out of 8 cases of AODM showed a similar response to controls, while 3H-thymidine uptake was low or absent in the remaining cases, including all those with CDM. Chlorphenamidine 231-234 insulin Homo sapiens 29-36 1021597-2 1976 A 3-point cross involving Va, cdm, and amylase-1 (Amy-1) indicated the following gene order and approximate distances: Va-8-cdm-17-Amy-1. Chlorphenamidine 124-127 amylase 1, salivary Mus musculus 39-48 7235738-1 1981 The 40-day oral administration of 5, 10, and 50 mg/kg chlordimeform to male rats moderately decreased monoamine oxidase activity (MAO) in the brain, liver, and serum, determined with the substrates kynuramine, tyramine, tryptamine, serotonin, dopamine, and benzylamine. Chlorphenamidine 54-67 monoamine oxidase A Rattus norvegicus 130-133 1021597-2 1976 A 3-point cross involving Va, cdm, and amylase-1 (Amy-1) indicated the following gene order and approximate distances: Va-8-cdm-17-Amy-1. Chlorphenamidine 124-127 amylase 1, salivary Mus musculus 50-55 1021597-2 1976 A 3-point cross involving Va, cdm, and amylase-1 (Amy-1) indicated the following gene order and approximate distances: Va-8-cdm-17-Amy-1. Chlorphenamidine 124-127 amylase 1, salivary Mus musculus 131-136 29894913-4 2018 The goal of the current study was to engineer cartilage and bone constructs with the ability to inhibit aberrant inflammatory processes caused by the cytokine interleukin-1 (IL-1), through scaffold-mediated delivery of lentiviral particles containing a doxycycline-inducible IL-1 receptor antagonist (IL-1Ra) transgene on anatomically-shaped CDM constructs. Chlorphenamidine 342-345 interleukin 1 alpha Homo sapiens 174-178 33224624-3 2020 A representative CTL epitope, ovalbumin (OVA) peptide antigen, was covalently conjugated to the polymer backbone through an acid responsive carboxy-dimethylmaleic amide linker (CDM) resulting in polymer P-CDM-OVA. Chlorphenamidine 177-180 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 30-39 33224624-3 2020 A representative CTL epitope, ovalbumin (OVA) peptide antigen, was covalently conjugated to the polymer backbone through an acid responsive carboxy-dimethylmaleic amide linker (CDM) resulting in polymer P-CDM-OVA. Chlorphenamidine 177-180 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 41-44 31357893-4 2019 Based on it, this paper builds HES-TG100-115-CDM-PEG micelles with tumor microenvironment responsiveness that simultaneously loaded sorafenib and TG100-115 to synergistically treat liver cancer. Chlorphenamidine 45-48 ribosome binding protein 1 Homo sapiens 31-34 31357893-8 2019 These findings reveal that HES-TG100-115-CDM-PEG micelles are a promising drug delivery system in clinical comprehensive therapy of liver cancer. Chlorphenamidine 41-44 ribosome binding protein 1 Homo sapiens 27-30 32705859-6 2020 An increase of the PCMT1 expression levels was found in Abeta25-35 + NSC-CDM group. Chlorphenamidine 73-76 protein-L-isoaspartate (D-aspartate) O-methyltransferase Homo sapiens 19-24 31471733-10 2020 DM improved in 23% of cDM, and 55% of insulin users in cDM discontinued using insulin. Chlorphenamidine 55-58 insulin Homo sapiens 38-45 31471733-10 2020 DM improved in 23% of cDM, and 55% of insulin users in cDM discontinued using insulin. Chlorphenamidine 55-58 insulin Homo sapiens 78-85 31432192-8 2019 NK-CdM induced proliferation of UV-B-treated NHDFs, increased procollagen expression, and decreased matrix metalloproteinase (MMP)-1 expression. Chlorphenamidine 3-6 matrix metallopeptidase 1 Homo sapiens 100-132 31396753-2 2019 Supplementation with 25 mg/l in CDM media resulted in a significant increase in EPO (1.7-fold) and IgG (2.6-fold) titers compared to control (no added zinc). Chlorphenamidine 32-35 erythropoietin Cricetulus griseus 80-83 31396753-3 2019 Titers at this Zn concentration in CDM containing the insulin replacing agent aurintricarboxylic acid (ATA) (CDM + A) showed a 1.8-fold (EPO) and 1.2-fold (IgG) titers increase compared to control. Chlorphenamidine 35-38 erythropoietin Cricetulus griseus 137-140 31188831-9 2019 APOBEC3F and 3G mRNA expression was also induced by CDM-3008 and IFNalpha treatments, suggesting that cccDNA could be degraded through induced APOBEC3 family proteins. Chlorphenamidine 52-55 apolipoprotein B mRNA editing enzyme catalytic subunit 3F Homo sapiens 0-15 31188831-9 2019 APOBEC3F and 3G mRNA expression was also induced by CDM-3008 and IFNalpha treatments, suggesting that cccDNA could be degraded through induced APOBEC3 family proteins. Chlorphenamidine 52-55 interferon alpha 1 Homo sapiens 65-73 30374958-6 2018 This CDM was used to identify the concepts of interests (COI) to evaluate outcomes of preventive treatments. Chlorphenamidine 5-8 mitochondrially encoded cytochrome c oxidase I Homo sapiens 57-60 29459675-2 2018 Here, we found that co-transplantation of allogeneic pancreatic islets with Tregs that are defective in c-Jun N-terminal kinase 1 (JNK1) signaling prolongs islet allograft survival in the liver parenchyma of chemically induced diabetic mice (CDM). Chlorphenamidine 242-245 mitogen-activated protein kinase 8 Mus musculus 131-135 27504608-2 2017 The CDM family consists of 11 mammalian members and is classified into four subfamilies, the DOCK-A, -B, -C, and -D. DOCK2 is a member of DOCK-A subfamily and an atypical guanine exchange factor regulating the loading of GTP to activate Rac. Chlorphenamidine 4-7 dedicator of cytokinesis 2 Homo sapiens 117-122 28196956-7 2017 Furthermore, a mutation in the ackA gene, coding for acetate kinase, also abrogated growth of JE2 in CDM, suggesting that ATP production from pyruvate-producing amino acids is also critical for growth. Chlorphenamidine 101-104 AT695_RS08960 Staphylococcus aureus 53-67 28412246-5 2017 Notably, VEGFa in NUCKS-/--BM-MSCs-CdM was higher than that of WT-BM-MSCs-CdM. Chlorphenamidine 35-38 vascular endothelial growth factor A Mus musculus 9-14 28412246-5 2017 Notably, VEGFa in NUCKS-/--BM-MSCs-CdM was higher than that of WT-BM-MSCs-CdM. Chlorphenamidine 35-38 nuclear casein kinase and cyclin-dependent kinase substrate 1 Mus musculus 18-23 27455260-2 2016 However, mmWave cellular systems with CDM-based preambles require a large number of cell IDs (CIDs) and BIDs, and a high computational complexity for CID and BID (CBID) searches. Chlorphenamidine 38-41 BH3 interacting domain death agonist Homo sapiens 104-107 27716228-7 2016 This CDM was used to identify concepts of interest (COI) to evaluate patient-relevant outcomes for assessing treatment benefit of migraine prophylactics. Chlorphenamidine 5-8 mitochondrially encoded cytochrome c oxidase I Homo sapiens 52-55 26577060-7 2016 RESULTS: MSC-CdM markedly reduced UV-induced matrix metalloproteinase-1 expression and increased pro-collagen synthesis in a dose-dependent manner. Chlorphenamidine 13-16 matrix metallopeptidase 1 Homo sapiens 45-71 26069241-9 2016 CP/CPB induced more phosphorylation of VE-cadherin in all groups (versus pre-CP/CPB; P < 0.05, respectively) and this effect was more pronounced in the UDM group (P < 0.05 versus ND or CDM). Chlorphenamidine 191-194 carboxypeptidase B1 Homo sapiens 0-6 26069241-9 2016 CP/CPB induced more phosphorylation of VE-cadherin in all groups (versus pre-CP/CPB; P < 0.05, respectively) and this effect was more pronounced in the UDM group (P < 0.05 versus ND or CDM). Chlorphenamidine 191-194 cadherin 5 Homo sapiens 39-50 26316598-9 2015 Comparing randomized groups by 48-week CD4 count, the mortality risk associated with CDM versus LCM was greater in persons with CD4 counts of <100 (hazard ratio = 2.4, 95% CI: 1.3, 4.3) than in those with CD4 counts of >=100 (hazard ratio = 1.1, 95% CI: 0.8, 1.7; interaction P = 0.04). Chlorphenamidine 85-88 CD4 molecule Homo sapiens 39-42 26316598-9 2015 Comparing randomized groups by 48-week CD4 count, the mortality risk associated with CDM versus LCM was greater in persons with CD4 counts of <100 (hazard ratio = 2.4, 95% CI: 1.3, 4.3) than in those with CD4 counts of >=100 (hazard ratio = 1.1, 95% CI: 0.8, 1.7; interaction P = 0.04). Chlorphenamidine 85-88 CD4 molecule Homo sapiens 128-131 26316598-9 2015 Comparing randomized groups by 48-week CD4 count, the mortality risk associated with CDM versus LCM was greater in persons with CD4 counts of <100 (hazard ratio = 2.4, 95% CI: 1.3, 4.3) than in those with CD4 counts of >=100 (hazard ratio = 1.1, 95% CI: 0.8, 1.7; interaction P = 0.04). Chlorphenamidine 85-88 CD4 molecule Homo sapiens 128-131 23008026-9 2013 In CDM, AdBMP-2 decreased viability (76% versus 90%), but increased BMP-2 production (619 ng/mL versus 43 pg/mL). Chlorphenamidine 3-6 bone morphogenetic protein 2 Homo sapiens 10-15 26057572-7 2015 Analysis of common and distinct cytokines revealed that macrophage migration inhibitory factor (MIF) and growth differentiation factor-15 (GDF-15) were uniquely overpresented in iPSC-MSC-CdM. Chlorphenamidine 187-190 macrophage migration inhibitory factor Homo sapiens 56-94 26057572-7 2015 Analysis of common and distinct cytokines revealed that macrophage migration inhibitory factor (MIF) and growth differentiation factor-15 (GDF-15) were uniquely overpresented in iPSC-MSC-CdM. Chlorphenamidine 187-190 macrophage migration inhibitory factor Homo sapiens 96-99 26057572-7 2015 Analysis of common and distinct cytokines revealed that macrophage migration inhibitory factor (MIF) and growth differentiation factor-15 (GDF-15) were uniquely overpresented in iPSC-MSC-CdM. Chlorphenamidine 187-190 growth differentiation factor 15 Homo sapiens 105-137 26057572-7 2015 Analysis of common and distinct cytokines revealed that macrophage migration inhibitory factor (MIF) and growth differentiation factor-15 (GDF-15) were uniquely overpresented in iPSC-MSC-CdM. Chlorphenamidine 187-190 growth differentiation factor 15 Homo sapiens 139-145 26057572-8 2015 Immunodepletion of MIF and GDF-15 in iPSC-MSCs-CdM dramatically decreased cardioprotection. Chlorphenamidine 47-50 macrophage migration inhibitory factor Homo sapiens 19-22 26057572-8 2015 Immunodepletion of MIF and GDF-15 in iPSC-MSCs-CdM dramatically decreased cardioprotection. Chlorphenamidine 47-50 growth differentiation factor 15 Homo sapiens 27-33 26057572-10 2015 We suggest that the potent paracrine effects of iPSC-MSCs provide novel "cell-free" therapeutic cardioprotection against AIC, and that MIF and GDF-15 in iPSC-MSCs-CdM are critical for these enhanced cardioprotective effects. Chlorphenamidine 163-166 macrophage migration inhibitory factor Homo sapiens 135-138 26057572-10 2015 We suggest that the potent paracrine effects of iPSC-MSCs provide novel "cell-free" therapeutic cardioprotection against AIC, and that MIF and GDF-15 in iPSC-MSCs-CdM are critical for these enhanced cardioprotective effects. Chlorphenamidine 163-166 growth differentiation factor 15 Homo sapiens 143-149 23773291-10 2013 In contrast, patients with CDM had higher levels of IL-10 (p < 0.0001) as well as Glu and TNF-alpha (all p < 0.05) and lower levels of NSE and active MMP-9 (all p < 0.0001). Chlorphenamidine 27-30 interleukin 10 Homo sapiens 52-57 23773291-10 2013 In contrast, patients with CDM had higher levels of IL-10 (p < 0.0001) as well as Glu and TNF-alpha (all p < 0.05) and lower levels of NSE and active MMP-9 (all p < 0.0001). Chlorphenamidine 27-30 tumor necrosis factor Homo sapiens 93-102 23773291-10 2013 In contrast, patients with CDM had higher levels of IL-10 (p < 0.0001) as well as Glu and TNF-alpha (all p < 0.05) and lower levels of NSE and active MMP-9 (all p < 0.0001). Chlorphenamidine 27-30 enolase 2 Homo sapiens 141-144 23773291-10 2013 In contrast, patients with CDM had higher levels of IL-10 (p < 0.0001) as well as Glu and TNF-alpha (all p < 0.05) and lower levels of NSE and active MMP-9 (all p < 0.0001). Chlorphenamidine 27-30 matrix metallopeptidase 9 Homo sapiens 156-161 23773291-12 2013 IL-10 levels >=30 pg/mL independently in both patients with PDM (OR, 18.9) and CDM (OR, 7.5), after an adjustment for covariates. Chlorphenamidine 82-85 interleukin 10 Homo sapiens 0-5 23773291-13 2013 CONCLUSIONS: Serum levels of IL-10 facilitate the selection of ischemic stroke patients with CDM and PDM for systemic thrombolysis. Chlorphenamidine 93-96 interleukin 10 Homo sapiens 29-34 24375991-7 2014 The predominant effects on hASCs of incorporation of CDM into scaffolds were to stimulate sulfated glycosaminoglycan synthesis and COL10A1 gene expression. Chlorphenamidine 53-56 collagen type X alpha 1 chain Homo sapiens 131-138 23972649-8 2013 Post-CP/CPB levels of phospho-ERK1/2 were increased in the ND and CDM groups but were decreased in the UDM group compared to their pre-CP/CPB levels, respectively (P < .05). Chlorphenamidine 66-69 mitogen-activated protein kinase 3 Homo sapiens 30-36 23972649-12 2013 Post-CP/CPB levels of MKP-1, however, remained greater in the UDM group than in the ND and CDM groups. Chlorphenamidine 91-94 dual specificity phosphatase 1 Homo sapiens 22-27 21283588-2 2011 One class of signaling proteins that regulate actin cytoskeletal rearrangement is the evolutionarily conserved CDM (C. elegansCed-5, human DOCK180, DrosophilaMyoblast city, or Mbc) family of proteins, which function as unconventional guanine nucleotide exchange factors for the small GTPase Rac. Chlorphenamidine 111-114 dedicator of cytokinesis 1 Homo sapiens 139-146 21836082-7 2011 Patients with CDM had higher serum levels of interleukin-10, tumor necrosis factor-alpha, and glutamate and lower serum levels of neuron-specific enolase, interleukin-6, and active matrix metalloproteinase-9 (all P<0.0001). Chlorphenamidine 14-17 interleukin 10 Homo sapiens 45-88 21836082-7 2011 Patients with CDM had higher serum levels of interleukin-10, tumor necrosis factor-alpha, and glutamate and lower serum levels of neuron-specific enolase, interleukin-6, and active matrix metalloproteinase-9 (all P<0.0001). Chlorphenamidine 14-17 enolase 2 Homo sapiens 130-153 21836082-7 2011 Patients with CDM had higher serum levels of interleukin-10, tumor necrosis factor-alpha, and glutamate and lower serum levels of neuron-specific enolase, interleukin-6, and active matrix metalloproteinase-9 (all P<0.0001). Chlorphenamidine 14-17 interleukin 6 Homo sapiens 155-168 21836082-7 2011 Patients with CDM had higher serum levels of interleukin-10, tumor necrosis factor-alpha, and glutamate and lower serum levels of neuron-specific enolase, interleukin-6, and active matrix metalloproteinase-9 (all P<0.0001). Chlorphenamidine 14-17 matrix metallopeptidase 9 Homo sapiens 181-207 21836082-9 2011 The association of interleukin-10>=23 pg/mL and glutamate>=230 mumol/L levels predicted CDM with a sensitivity of 96% and a specificity of 98%. Chlorphenamidine 94-97 interleukin 10 Homo sapiens 19-33 21836082-10 2011 CONCLUSIONS: High levels of interleukin-10, tumor necrosis factor-alpha, and glutamate as well as low levels of neuron-specific enolase, interleukin-6, and active matrix metalloproteinase-9 are associated with CDM. Chlorphenamidine 210-213 interleukin 10 Homo sapiens 28-71 21836082-10 2011 CONCLUSIONS: High levels of interleukin-10, tumor necrosis factor-alpha, and glutamate as well as low levels of neuron-specific enolase, interleukin-6, and active matrix metalloproteinase-9 are associated with CDM. Chlorphenamidine 210-213 enolase 2 Homo sapiens 112-135 21836082-10 2011 CONCLUSIONS: High levels of interleukin-10, tumor necrosis factor-alpha, and glutamate as well as low levels of neuron-specific enolase, interleukin-6, and active matrix metalloproteinase-9 are associated with CDM. Chlorphenamidine 210-213 matrix metallopeptidase 9 Homo sapiens 163-189 21217142-5 2011 CD4+CD28(null)T-cell frequency (median, range) was higher in ACS/DM+ (12.7%, 0.1-48) vs. ACS/DM- (3.9%, 0.2-35), cDM (3.1%, 0.3-22.4), and controls (1.5%, 0.1-9.1) (P< 0.001 for all comparisons). Chlorphenamidine 113-116 CD4 molecule Homo sapiens 0-3 22528216-9 2012 Moreover, the expression of SDF-1alpha, VEGF and IL-6 in MSC-CdM(HYP) group was up-regulated. Chlorphenamidine 61-64 vascular endothelial growth factor A Homo sapiens 40-44 22528216-9 2012 Moreover, the expression of SDF-1alpha, VEGF and IL-6 in MSC-CdM(HYP) group was up-regulated. Chlorphenamidine 61-64 interleukin 6 Homo sapiens 49-53 22568209-5 2012 After exposure to PDGF or EGF, the number of cells was increased in the NM group, but there were more detached and apoptotic cells in the CDM group than in the former (P < 0.05). Chlorphenamidine 138-141 epidermal growth factor Homo sapiens 26-29 21187256-7 2011 Of the 32 CDM-positive cases, 10 received t-PA infusion. Chlorphenamidine 10-13 plasminogen activator, tissue type Homo sapiens 42-46 19407226-2 2009 We hypothesized that in the 3- to 6-hour time window, the effect of tPA was significantly greater in patients with CDM than in patients without CDM. Chlorphenamidine 115-118 plasminogen activator, tissue type Homo sapiens 68-71 19407226-2 2009 We hypothesized that in the 3- to 6-hour time window, the effect of tPA was significantly greater in patients with CDM than in patients without CDM. Chlorphenamidine 144-147 plasminogen activator, tissue type Homo sapiens 68-71 18163987-1 2008 Members of the CDM (CED-5, Dock180, Myoblast city) superfamily of guanine nucleotide exchange factors function in diverse processes that include cell migration and myoblast fusion. Chlorphenamidine 15-18 myoblast city Drosophila melanogaster 27-34 18472229-9 2008 Both animal and human data suggest that methionine synthase also requires copper, implying that the enzyme may be involved in the pathogenesis of CDM. Chlorphenamidine 146-149 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 40-59 17540857-7 2007 The effects of CdM(Hyp) on hypoxic HAECs were partially duplicated by the addition of IL-6 in a dose-dependent manner; however, anti-IL-6, anti-MCP-1, and anti-VEGF blocking antibodies added independently did not attenuate the effects. Chlorphenamidine 15-18 interleukin 6 Homo sapiens 86-90 17540857-8 2007 Also, addition of CdM(Hyp) activated the PI3K-Akt pathway; the levels of p-Akt and several of its downstream targets were increased by CdM(Hyp), and both the increase in p-Akt and the increase in angiogenesis were blocked by an inhibitor of PI3K-Akt or by expression of a dominant negative gene for PI3K. Chlorphenamidine 18-21 AKT serine/threonine kinase 1 Homo sapiens 46-49 17540857-8 2007 Also, addition of CdM(Hyp) activated the PI3K-Akt pathway; the levels of p-Akt and several of its downstream targets were increased by CdM(Hyp), and both the increase in p-Akt and the increase in angiogenesis were blocked by an inhibitor of PI3K-Akt or by expression of a dominant negative gene for PI3K. Chlorphenamidine 18-21 AKT serine/threonine kinase 1 Homo sapiens 75-78 17540857-8 2007 Also, addition of CdM(Hyp) activated the PI3K-Akt pathway; the levels of p-Akt and several of its downstream targets were increased by CdM(Hyp), and both the increase in p-Akt and the increase in angiogenesis were blocked by an inhibitor of PI3K-Akt or by expression of a dominant negative gene for PI3K. Chlorphenamidine 18-21 AKT serine/threonine kinase 1 Homo sapiens 75-78 17540857-8 2007 Also, addition of CdM(Hyp) activated the PI3K-Akt pathway; the levels of p-Akt and several of its downstream targets were increased by CdM(Hyp), and both the increase in p-Akt and the increase in angiogenesis were blocked by an inhibitor of PI3K-Akt or by expression of a dominant negative gene for PI3K. Chlorphenamidine 18-21 AKT serine/threonine kinase 1 Homo sapiens 75-78 17540857-8 2007 Also, addition of CdM(Hyp) activated the PI3K-Akt pathway; the levels of p-Akt and several of its downstream targets were increased by CdM(Hyp), and both the increase in p-Akt and the increase in angiogenesis were blocked by an inhibitor of PI3K-Akt or by expression of a dominant negative gene for PI3K. Chlorphenamidine 135-138 AKT serine/threonine kinase 1 Homo sapiens 46-49 17540857-8 2007 Also, addition of CdM(Hyp) activated the PI3K-Akt pathway; the levels of p-Akt and several of its downstream targets were increased by CdM(Hyp), and both the increase in p-Akt and the increase in angiogenesis were blocked by an inhibitor of PI3K-Akt or by expression of a dominant negative gene for PI3K. Chlorphenamidine 135-138 AKT serine/threonine kinase 1 Homo sapiens 75-78 17540857-8 2007 Also, addition of CdM(Hyp) activated the PI3K-Akt pathway; the levels of p-Akt and several of its downstream targets were increased by CdM(Hyp), and both the increase in p-Akt and the increase in angiogenesis were blocked by an inhibitor of PI3K-Akt or by expression of a dominant negative gene for PI3K. Chlorphenamidine 135-138 AKT serine/threonine kinase 1 Homo sapiens 75-78 17540857-8 2007 Also, addition of CdM(Hyp) activated the PI3K-Akt pathway; the levels of p-Akt and several of its downstream targets were increased by CdM(Hyp), and both the increase in p-Akt and the increase in angiogenesis were blocked by an inhibitor of PI3K-Akt or by expression of a dominant negative gene for PI3K. Chlorphenamidine 135-138 AKT serine/threonine kinase 1 Homo sapiens 75-78 17540857-9 2007 CdM(Hyp) also increased the levels of p-extracellular signal-regulated kinase (ERK), but there was a minimal effect on p-signal transducer and activator of transcription-3, and an inhibitor of the ERK1/2 pathway had no effect on hypoxia-induced apoptosis of the HAECs. Chlorphenamidine 0-3 mitogen-activated protein kinase 1 Homo sapiens 38-77 17540857-9 2007 CdM(Hyp) also increased the levels of p-extracellular signal-regulated kinase (ERK), but there was a minimal effect on p-signal transducer and activator of transcription-3, and an inhibitor of the ERK1/2 pathway had no effect on hypoxia-induced apoptosis of the HAECs. Chlorphenamidine 0-3 mitogen-activated protein kinase 1 Homo sapiens 79-82 17540857-9 2007 CdM(Hyp) also increased the levels of p-extracellular signal-regulated kinase (ERK), but there was a minimal effect on p-signal transducer and activator of transcription-3, and an inhibitor of the ERK1/2 pathway had no effect on hypoxia-induced apoptosis of the HAECs. Chlorphenamidine 0-3 mitogen-activated protein kinase 3 Homo sapiens 197-203 16325006-8 2005 Neural differentiation in CDM does not occur by a simple default mechanism, but was dependent on endogenous FGF signaling, and could be blocked by adding BMP4, and LiCl to simulate WNT activation. Chlorphenamidine 26-29 bone morphogenetic protein 4 Mus musculus 154-158 15723800-1 2005 CDM (CED-5, Dock180, Myoblast city) family members have been recently identified as novel, evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases . Chlorphenamidine 0-3 dedicator of cytokinesis 1 Homo sapiens 5-10 15723800-1 2005 CDM (CED-5, Dock180, Myoblast city) family members have been recently identified as novel, evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases . Chlorphenamidine 0-3 dedicator of cytokinesis 1 Homo sapiens 12-19 17201160-3 2006 RESULTS: Concordance rate between PBC and CDM was 79% for HERI and HER2, 67% for HER3 and 56% or HER4. Chlorphenamidine 42-45 erb-b2 receptor tyrosine kinase 2 Homo sapiens 67-71