PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25216025-0	2015	Justicidin A-induced autophagy flux enhances apoptosis of human colorectal cancer cells via class III PI3K and Atg5 pathway.	justicidins	0-12	autophagy related 5	Homo sapiens	111-115
26887582-6	2016	These studies showed that justicidin A inhibited activity of glycogen synthase kinase-3beta (GSK-3beta), which is an important kinase in up-stream signaling pathways; inhibited hyperphosphorylation of tau in AD; and enhanced activity of AMP-activated protein kinase (AMPK), which is the key molecule for both hyperphosphorylation of tau and induction of autophagy.	justicidins	26-38	glycogen synthase kinase 3 beta	Homo sapiens	61-91
26887582-6	2016	These studies showed that justicidin A inhibited activity of glycogen synthase kinase-3beta (GSK-3beta), which is an important kinase in up-stream signaling pathways; inhibited hyperphosphorylation of tau in AD; and enhanced activity of AMP-activated protein kinase (AMPK), which is the key molecule for both hyperphosphorylation of tau and induction of autophagy.	justicidins	26-38	glycogen synthase kinase 3 beta	Homo sapiens	93-102
26887582-7	2016	These data provide the first evidence that justicidin A protects SH-SY5Y cells from Abeta25-35-induced neuronal cell death through inhibition of hyperphosphorylation of tau and induction of autophagy via regulation the activity of GSK-3beta and AMPK, and they also provide some insights into the relationship between tau protein hyperphosphorylation and autophagy.	justicidins	43-55	glycogen synthase kinase 3 beta	Homo sapiens	231-240
25216025-2	2015	Here, we reveal that JA induces autophagy in human colorectal cancer HT-29 cells by conversion of autophagic marker LC3-I to LC3-II.	justicidins	21-23	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	116-119
25216025-2	2015	Here, we reveal that JA induces autophagy in human colorectal cancer HT-29 cells by conversion of autophagic marker LC3-I to LC3-II.	justicidins	21-23	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	125-128
25216025-4	2015	Administration of autophagy inhibitor (bafilomycin A1 and chloroquine) and transfection of a tandem fluorescent-tagged LC3 (mRFP-GFP) reporter plasmid (ptfLC3) demonstrated that JA induces autophagy flux in HT-29 cells.	justicidins	178-180	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	119-122
25216025-7	2015	Pre-treatment of the cells with class III PI3K inhibitor 3-methyladenine or Atg5 shRNA attenuated JA-induced LC3-II expression and LC3 puncta formation, indicating the involvement of class III PI3K and Atg5.	justicidins	98-100	autophagy related 5	Homo sapiens	76-80
25216025-7	2015	Pre-treatment of the cells with class III PI3K inhibitor 3-methyladenine or Atg5 shRNA attenuated JA-induced LC3-II expression and LC3 puncta formation, indicating the involvement of class III PI3K and Atg5.	justicidins	98-100	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	109-112
25216025-7	2015	Pre-treatment of the cells with class III PI3K inhibitor 3-methyladenine or Atg5 shRNA attenuated JA-induced LC3-II expression and LC3 puncta formation, indicating the involvement of class III PI3K and Atg5.	justicidins	98-100	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	131-134
25216025-7	2015	Pre-treatment of the cells with class III PI3K inhibitor 3-methyladenine or Atg5 shRNA attenuated JA-induced LC3-II expression and LC3 puncta formation, indicating the involvement of class III PI3K and Atg5.	justicidins	98-100	autophagy related 5	Homo sapiens	202-206
25216025-8	2015	A novel mechanism was demonstrated in the anticancer compound JA; pre-treatment with 3-methyladenine or Atg5 shRNA blocked JA-induced suppression in cell growth and colony formation, respectively, via inhibition of apoptosis.	justicidins	62-64	autophagy related 5	Homo sapiens	104-108
17465217-8	2007	In addition, we demonstrated that genistein and justicidin A, natural chemoprevention agents, could suppress the expression of PHB in vitro.	justicidins	48-60	prohibitin 1	Homo sapiens	127-130
10425143-3	1999	The known compound, justicidin A, showed potent cytotoxic effects against T-24, CaSki, SiHa, HT-3, PLC/PRF/5, and 212 cells in vitro.	justicidins	20-32	hypothermia due to alcohol sensitivity 3	Mus musculus	93-97
16684533-0	2006	Caspase-8 acts as a key upstream executor of mitochondria during justicidin A-induced apoptosis in human hepatoma cells.	justicidins	65-77	caspase 8	Homo sapiens	0-9
16684533-3	2006	In this study, justicidin A activated caspase-8 to increase tBid, disrupted mitochondrial membrane potential (Delta psi(m)), and caused the release of cytochrome c and Smac/DIABLO in Hep 3B and Hep G2 cells.	justicidins	15-27	caspase 8	Homo sapiens	38-47
16684533-3	2006	In this study, justicidin A activated caspase-8 to increase tBid, disrupted mitochondrial membrane potential (Delta psi(m)), and caused the release of cytochrome c and Smac/DIABLO in Hep 3B and Hep G2 cells.	justicidins	15-27	cytochrome c, somatic	Homo sapiens	151-163
16684533-3	2006	In this study, justicidin A activated caspase-8 to increase tBid, disrupted mitochondrial membrane potential (Delta psi(m)), and caused the release of cytochrome c and Smac/DIABLO in Hep 3B and Hep G2 cells.	justicidins	15-27	diablo IAP-binding mitochondrial protein	Homo sapiens	168-172
16684533-3	2006	In this study, justicidin A activated caspase-8 to increase tBid, disrupted mitochondrial membrane potential (Delta psi(m)), and caused the release of cytochrome c and Smac/DIABLO in Hep 3B and Hep G2 cells.	justicidins	15-27	diablo IAP-binding mitochondrial protein	Homo sapiens	173-179
16684533-4	2006	Justicidin A also reduced Bcl-x(L) and increased Bax and Bak in mitochondria.	justicidins	0-12	BCL2 like 1	Homo sapiens	26-34
16684533-4	2006	Justicidin A also reduced Bcl-x(L) and increased Bax and Bak in mitochondria.	justicidins	0-12	BCL2 associated X, apoptosis regulator	Homo sapiens	49-52
16684533-4	2006	Justicidin A also reduced Bcl-x(L) and increased Bax and Bak in mitochondria.	justicidins	0-12	BCL2 antagonist/killer 1	Homo sapiens	57-60
16684533-5	2006	Caspase-8 inhibitor (Z-IETD) attenuated the justicidin A-induced disruption of Delta psi(m).	justicidins	44-56	caspase 8	Homo sapiens	0-9
16684533-7	2006	These results indicate that justicidin A-induced apoptosis in these cells proceeds via caspase-8 and is followed by mitochondrial disruption.	justicidins	28-40	caspase 8	Homo sapiens	87-96
15905197-0	2005	Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells.	justicidins	0-12	X-ray repair cross complementing 6	Homo sapiens	46-50
15905197-5	2005	Caspase-9 but not caspase-8 was activated, suggesting that justicidin A treatment damaged mitochondria.	justicidins	59-71	caspase 9	Homo sapiens	0-9
15905197-6	2005	The mitochondrial membrane potential was altered and cytochrome c and Smac were released from mitochondria to the cytoplasm upon justicidin A treatment.	justicidins	129-141	cytochrome c, somatic	Homo sapiens	53-65
15905197-6	2005	The mitochondrial membrane potential was altered and cytochrome c and Smac were released from mitochondria to the cytoplasm upon justicidin A treatment.	justicidins	129-141	diablo IAP-binding mitochondrial protein	Homo sapiens	70-74
15905197-7	2005	The level of Ku70 in the cytoplasm was decreased, but that of Bax in mitochondria was increased by justicidin A.	justicidins	99-111	BCL2 associated X, apoptosis regulator	Homo sapiens	62-65
15905197-8	2005	Since Ku70 normally binds and sequesters Bax, these results suggest that justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis.	justicidins	73-85	X-ray repair cross complementing 6	Homo sapiens	6-10
15905197-8	2005	Since Ku70 normally binds and sequesters Bax, these results suggest that justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis.	justicidins	73-85	BCL2 associated X, apoptosis regulator	Homo sapiens	41-44
15905197-8	2005	Since Ku70 normally binds and sequesters Bax, these results suggest that justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis.	justicidins	73-85	X-ray repair cross complementing 6	Homo sapiens	109-113
15905197-8	2005	Since Ku70 normally binds and sequesters Bax, these results suggest that justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis.	justicidins	73-85	BCL2 associated X, apoptosis regulator	Homo sapiens	142-145
10425143-3	1999	The known compound, justicidin A, showed potent cytotoxic effects against T-24, CaSki, SiHa, HT-3, PLC/PRF/5, and 212 cells in vitro.	justicidins	20-32	heparan sulfate proteoglycan 2	Homo sapiens	99-102
34433871-9	2021	In conclusion, the core bioactive components, especially justicidin D, can reduce thrombosis by regulating F2, MMP9, CXCL12, MET, RAC1, PDE5A, and ABCB1.	justicidins	57-69	matrix metallopeptidase 9	Homo sapiens	111-115
34433871-9	2021	In conclusion, the core bioactive components, especially justicidin D, can reduce thrombosis by regulating F2, MMP9, CXCL12, MET, RAC1, PDE5A, and ABCB1.	justicidins	57-69	C-X-C motif chemokine ligand 12	Homo sapiens	117-123
34433871-9	2021	In conclusion, the core bioactive components, especially justicidin D, can reduce thrombosis by regulating F2, MMP9, CXCL12, MET, RAC1, PDE5A, and ABCB1.	justicidins	57-69	SAFB like transcription modulator	Homo sapiens	125-128
34433871-9	2021	In conclusion, the core bioactive components, especially justicidin D, can reduce thrombosis by regulating F2, MMP9, CXCL12, MET, RAC1, PDE5A, and ABCB1.	justicidins	57-69	Rac family small GTPase 1	Homo sapiens	130-134
34433871-9	2021	In conclusion, the core bioactive components, especially justicidin D, can reduce thrombosis by regulating F2, MMP9, CXCL12, MET, RAC1, PDE5A, and ABCB1.	justicidins	57-69	phosphodiesterase 5A	Homo sapiens	136-141
34433871-9	2021	In conclusion, the core bioactive components, especially justicidin D, can reduce thrombosis by regulating F2, MMP9, CXCL12, MET, RAC1, PDE5A, and ABCB1.	justicidins	57-69	ATP binding cassette subfamily B member 1	Homo sapiens	147-152
34159141-8	2021	Justicidin D had binding affinities of -8.7, -8.1, and -7.6 kcal mol-1 on RdRp, 3CLpro, and spike, respectively.	justicidins	0-12	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	74-78
34159141-8	2021	Justicidin D had binding affinities of -8.7, -8.1, and -7.6 kcal mol-1 on RdRp, 3CLpro, and spike, respectively.	justicidins	0-12	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	92-97
28275053-5	2017	The plant lignan justicidin B blocked the constitutive internalization of LGR5.	justicidins	17-29	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	74-78
29512870-7	2018	Additionally, DW2008S and JA antagonized human adenosine receptor A3 (A3 AR), which mediates mast cell-dependent inflammation and bronchoconstriction.	justicidins	26-28	adenosine A3 receptor	Homo sapiens	47-68
29512870-7	2018	Additionally, DW2008S and JA antagonized human adenosine receptor A3 (A3 AR), which mediates mast cell-dependent inflammation and bronchoconstriction.	justicidins	26-28	adenosine A3 receptor	Homo sapiens	70-75
29221182-0	2017	Differential modulation of Bax/Bcl-2 ratio and onset of caspase-3/7 activation induced by derivatives of Justicidin B in human melanoma cells A375.	justicidins	105-117	caspase 3	Homo sapiens	56-65
29221182-4	2017	Diphyllin methyl ether (GI50 = 3.66 muM) and Justicidin B (GI50 = 1.70 muM) caused an elevation of both early and late apoptosis populations whereas Diphyllin apioside (GI50 = 0.84 muM) and its acetate (GI50= 0.39 muM) enhanced late apoptosis population only (Annexin V-positive/PI-positive).	justicidins	45-57	latexin	Homo sapiens	71-74
29221182-4	2017	Diphyllin methyl ether (GI50 = 3.66 muM) and Justicidin B (GI50 = 1.70 muM) caused an elevation of both early and late apoptosis populations whereas Diphyllin apioside (GI50 = 0.84 muM) and its acetate (GI50= 0.39 muM) enhanced late apoptosis population only (Annexin V-positive/PI-positive).	justicidins	45-57	latexin	Homo sapiens	71-74
29221182-4	2017	Diphyllin methyl ether (GI50 = 3.66 muM) and Justicidin B (GI50 = 1.70 muM) caused an elevation of both early and late apoptosis populations whereas Diphyllin apioside (GI50 = 0.84 muM) and its acetate (GI50= 0.39 muM) enhanced late apoptosis population only (Annexin V-positive/PI-positive).	justicidins	45-57	latexin	Homo sapiens	71-74
29221182-4	2017	Diphyllin methyl ether (GI50 = 3.66 muM) and Justicidin B (GI50 = 1.70 muM) caused an elevation of both early and late apoptosis populations whereas Diphyllin apioside (GI50 = 0.84 muM) and its acetate (GI50= 0.39 muM) enhanced late apoptosis population only (Annexin V-positive/PI-positive).	justicidins	45-57	annexin A5	Homo sapiens	260-269
28275053-6	2017	Justicidin B is structurally similar to more potent vacuolar-type H+-ATPase inhibitors, which all inhibited LGR5 internalization by blocking clathrin-mediated endocytosis.	justicidins	0-12	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	108-112
28378593-11	2017	Among them, justicidin A potently decreased the formation of Abeta in APPsw-transfected cells.	justicidins	12-24	amyloid beta precursor protein	Homo sapiens	61-66
28378593-13	2017	Furthermore, justicidin A may contribute, at least partially, to the Abeta alteration observed with the extract treatment.	justicidins	13-25	amyloid beta precursor protein	Homo sapiens	69-74