PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27998005-6	2017	These sex differences were eliminated by a treatment with isatin, a non-selective MAO inhibitor, and moclobemide, a selective MAOA inhibitor, but not by selegiline, a selective MAOB inhibitor.	Isatin	58-64	monoamine oxidase A	Rattus norvegicus	82-85
28320274-6	2017	Administration of isatin to mice prevented MPTP-induced inactivation of MAO B and influenced the profile of brain mitochondrial Rpn10-binding proteins, in which two pools of proteins were clearly recognized.	Isatin	18-24	monoamine oxidase B	Mus musculus	72-77
28414290-0	2017	[The effect of isatin on protein-protein interactions between cytochrome b5 and cytochromes P450].	Isatin	15-21	cytochrome b5 type A	Homo sapiens	62-75
28414290-2	2017	Since some CYP catalyze indol oxidation to isatin, we have hypothesized that isatin can regulate protein-protein interactions (PPI) between components of the CYP system thus representing a (negative?)	Isatin	43-49	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	158-161
28414290-2	2017	Since some CYP catalyze indol oxidation to isatin, we have hypothesized that isatin can regulate protein-protein interactions (PPI) between components of the CYP system thus representing a (negative?)	Isatin	77-83	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	11-14
28414290-2	2017	Since some CYP catalyze indol oxidation to isatin, we have hypothesized that isatin can regulate protein-protein interactions (PPI) between components of the CYP system thus representing a (negative?)	Isatin	77-83	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	158-161
28414290-4	2017	The aim of this study was to investigate a possible effect of isatin on interaction of human CYP with cytochrome b5 (CYB5A).	Isatin	62-68	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	93-96
28414290-4	2017	The aim of this study was to investigate a possible effect of isatin on interaction of human CYP with cytochrome b5 (CYB5A).	Isatin	62-68	cytochrome b5 type A	Homo sapiens	102-115
28414290-4	2017	The aim of this study was to investigate a possible effect of isatin on interaction of human CYP with cytochrome b5 (CYB5A).	Isatin	62-68	cytochrome b5 type A	Homo sapiens	117-122
28414290-6	2017	The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1).	Isatin	66-72	cytochrome b5 type A	Homo sapiens	116-121
28414290-6	2017	The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1).	Isatin	66-72	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	122-128
28414290-6	2017	The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1).	Isatin	66-72	cytochrome b5 type A	Homo sapiens	133-138
28414290-6	2017	The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1).	Isatin	66-72	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	139-145
28414290-6	2017	The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1).	Isatin	66-72	cytochrome b5 type A	Homo sapiens	133-138
28414290-6	2017	The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1).	Isatin	66-72	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	122-125
27233608-2	2016	In the present study we deciphered the mechanisms of action of URM-II-81, a new derivative of isatin, in alleviation of insulin resistance in human hepatocytes and murine adipocytes.	Isatin	94-100	insulin	Homo sapiens	120-127
28414290-6	2017	The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1).	Isatin	66-72	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	285-292
28414290-6	2017	The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1).	Isatin	66-72	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	297-303
28414290-7	2017	Isatin injection to the optical biosensor chip with the preformed molecular complex CYB5A/CYP3A4 caused a 30%-increase in its dissociation rate.	Isatin	0-6	cytochrome b5 type A	Homo sapiens	84-89
28414290-7	2017	Isatin injection to the optical biosensor chip with the preformed molecular complex CYB5A/CYP3A4 caused a 30%-increase in its dissociation rate.	Isatin	0-6	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	90-96
28414290-8	2017	Molecular docking manipulations have shown that isatin can influence interaction of CYP3A5 or CYP3A4 with CYB5A acting at the contact region of CYB5A/CYP.	Isatin	48-54	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	84-90
28414290-8	2017	Molecular docking manipulations have shown that isatin can influence interaction of CYP3A5 or CYP3A4 with CYB5A acting at the contact region of CYB5A/CYP.	Isatin	48-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	94-100
28414290-8	2017	Molecular docking manipulations have shown that isatin can influence interaction of CYP3A5 or CYP3A4 with CYB5A acting at the contact region of CYB5A/CYP.	Isatin	48-54	cytochrome b5 type A	Homo sapiens	106-111
28414290-8	2017	Molecular docking manipulations have shown that isatin can influence interaction of CYP3A5 or CYP3A4 with CYB5A acting at the contact region of CYB5A/CYP.	Isatin	48-54	cytochrome b5 type A	Homo sapiens	144-149
28414290-8	2017	Molecular docking manipulations have shown that isatin can influence interaction of CYP3A5 or CYP3A4 with CYB5A acting at the contact region of CYB5A/CYP.	Isatin	48-54	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	84-87
27374845-2	2016	By inhibiting MAO, isatin increases dopamine levels in the brain and, in animal models of Parkinson"s disease (PD) isatin is able to prevent dopamine depletion.	Isatin	115-121	monoamine oxidase A	Rattus norvegicus	14-17
29449910-2	2017	The preliminary evaluation studies revealed the compound 4t, with an optimal combination of bromo-substituent at the C-5 position of isatin ring along with propyl chain linker being most active among the synthesized series exhibiting an IC50 value of 3.72 muM against Trichomonas vaginalis while 4j exhibited an IC50 value of 14.8 muM against Naegleria fowleri, more effective than the standard drug Miltefosine.	Isatin	133-139	complement C5	Homo sapiens	117-120
27374845-0	2016	Effects and mechanism of action of isatin, a MAO inhibitor, on in vivo striatal dopamine release.	Isatin	35-41	monoamine oxidase A	Rattus norvegicus	45-48
27374845-1	2016	Isatin is an endogenous indole that inhibits monoamine oxidase (MAO), being more selective for MAO-B than MAO-A isoform.	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	45-62
27374845-1	2016	Isatin is an endogenous indole that inhibits monoamine oxidase (MAO), being more selective for MAO-B than MAO-A isoform.	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	64-67
27374845-1	2016	Isatin is an endogenous indole that inhibits monoamine oxidase (MAO), being more selective for MAO-B than MAO-A isoform.	Isatin	0-6	monoamine oxidase B	Rattus norvegicus	95-100
27374845-1	2016	Isatin is an endogenous indole that inhibits monoamine oxidase (MAO), being more selective for MAO-B than MAO-A isoform.	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	106-111
27374845-2	2016	By inhibiting MAO, isatin increases dopamine levels in the brain and, in animal models of Parkinson"s disease (PD) isatin is able to prevent dopamine depletion.	Isatin	19-25	monoamine oxidase A	Rattus norvegicus	14-17
27143373-0	2016	[Oxidative modification of glyceraldehyde-3-phosphate dehydrogenase influences its interaction with endogenous neuroprotector isatin].	Isatin	126-132	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	27-67
26734722-1	2016	A chiral complex derived from (S)-difluorophos and Hg(OTf)2 is identified as a powerful catalyst for the Sakurai-Hosomi reaction of isatins with allyltrimethylsilane, allowing the facile synthesis of valuable building blocks 3-allyl-3-hydroxyoxindoles in up to 97% ee, with only 0.5-1.0 mol% of catalyst loading.	Isatin	132-139	POU class 2 homeobox 2	Homo sapiens	54-59
27092477-7	2016	The higher iNOS inhibition activity of the tested Schiff bases, relative to that of COX-2, seems to be a reflection of the combined suppressive effects exerted by their nalidixic acid, isatins (4a-c), and l-amino acid moieties against iNOS expression.	Isatin	185-192	nitric oxide synthase 2, inducible	Mus musculus	11-15
27143373-2	2016	GAPDH binds isatin (indole-dione-2,3), an endogenous indole often used as a parent component in numerous derivatives demonstrating diverse pharmacological (including neuroprotector) activities.	Isatin	12-18	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-5
27143373-3	2016	In this study we have investigated binding of intact and mildly oxidized GAPDH to immobilized isatin, using an optical biosensor technique, employing surface plasmon resonance (SPR), and the effect of isatin as a probe for this binding.	Isatin	94-100	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	73-78
27143373-4	2016	Mild GAPDH oxidation by 70 mM H(2)O(2) increased enzyme dissociation from immobilized isatin.	Isatin	86-92	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	5-10
26846278-3	2016	The results demonstrated that the proportion of SH-SY5Y cells in G1 phase was significantly increased following treatment with isatin for 48 h with simultaneous downregulation of cyclin D1 expression.	Isatin	127-133	cyclin D1	Homo sapiens	179-188
26846278-4	2016	In addition, isatin significantly inhibited cell migration and invasion, along with decreases in matrix metalloproteinase (MMP)2 and MMP9 expression.	Isatin	13-19	matrix metallopeptidase 2	Homo sapiens	97-128
26846278-6	2016	These results demonstrated that isatin induces G1-phase arrest in SH-SY5Y cells, possibly by decreasing cyclin D1 expression as well as inhibiting their migration and invasiveness, probably by reducing MMP2 and MMP9.	Isatin	32-38	matrix metallopeptidase 9	Homo sapiens	211-215
26846278-4	2016	In addition, isatin significantly inhibited cell migration and invasion, along with decreases in matrix metalloproteinase (MMP)2 and MMP9 expression.	Isatin	13-19	matrix metallopeptidase 9	Homo sapiens	133-137
26846278-5	2016	In addition, isatin reduced the levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in a concentration-dependent manner.	Isatin	13-19	signal transducer and activator of transcription 3	Homo sapiens	57-107
26846278-6	2016	These results demonstrated that isatin induces G1-phase arrest in SH-SY5Y cells, possibly by decreasing cyclin D1 expression as well as inhibiting their migration and invasiveness, probably by reducing MMP2 and MMP9.	Isatin	32-38	cyclin D1	Homo sapiens	104-113
26846278-6	2016	These results demonstrated that isatin induces G1-phase arrest in SH-SY5Y cells, possibly by decreasing cyclin D1 expression as well as inhibiting their migration and invasiveness, probably by reducing MMP2 and MMP9.	Isatin	32-38	matrix metallopeptidase 2	Homo sapiens	202-206
27441242-0	2016	N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines.	Isatin	12-19	ATP binding cassette subfamily B member 1	Homo sapiens	26-30
27441242-6	2016	We show that one mechanism by which the isatin-based compounds overcome MDR is by circumventing P-glycoprotein (P-gp) mediated drug efflux.	Isatin	40-46	ATP binding cassette subfamily B member 1	Homo sapiens	96-110
27441242-6	2016	We show that one mechanism by which the isatin-based compounds overcome MDR is by circumventing P-glycoprotein (P-gp) mediated drug efflux.	Isatin	40-46	ATP binding cassette subfamily B member 1	Homo sapiens	112-116
27096472-0	2016	Insights into the mechanism of inhibition of tryptophan 2,3-dioxygenase by isatin derivatives.	Isatin	75-81	tryptophan 2,3-dioxygenase	Homo sapiens	45-71
27096472-5	2016	Hydrogen bond interactions between the compound and key active site residues of TDO, freedom upon rotation of the C3 chemical moiety and the presence of chlorines in the benzene ring of the compound comprise the properties that an isatin-based inhibitor requires to effectively inhibit the enzymatic activity of TDO.	Isatin	231-237	tryptophan 2,3-dioxygenase	Homo sapiens	80-83
27096472-3	2016	Herein, we report isatin derivatives as a new class of TDO inhibitors.	Isatin	18-24	tryptophan 2,3-dioxygenase	Homo sapiens	55-58
27096472-5	2016	Hydrogen bond interactions between the compound and key active site residues of TDO, freedom upon rotation of the C3 chemical moiety and the presence of chlorines in the benzene ring of the compound comprise the properties that an isatin-based inhibitor requires to effectively inhibit the enzymatic activity of TDO.	Isatin	231-237	tryptophan 2,3-dioxygenase	Homo sapiens	312-315
26515041-1	2015	Keeping in view the limitations associated with currently available anticancer drugs, molecular hybrids of mono carbonyl curcumin and isatin tethered by triazole ring have been synthesized and evaluated for in vitro cytotoxicity against THP-1, COLO-205, HCT-116, A549, HeLa, CAKI-I, PC-3, MiaPaca-2 human cancer cell lines.	Isatin	134-140	GLI family zinc finger 2	Homo sapiens	237-242
26307165-8	2015	We show in silico that NPR-C, a preferential CNP receptor, and the P. aeruginosa protein AmiC have similar three-dimensional (3D) structures and that both CNP and isatin bind to AmiC.	Isatin	163-169	natriuretic peptide receptor 3	Homo sapiens	23-28
26519157-14	2015	Novel bis-Schiff base of isatin showed significant antioxidant activity and also reduced receptor for AGEs (RAGE) expression and PKC-alpha activation therefore; MK-I-81 reduces AGEs induced insulin resistance.	Isatin	25-31	advanced glycosylation end product-specific receptor	Mus musculus	108-112
26519157-14	2015	Novel bis-Schiff base of isatin showed significant antioxidant activity and also reduced receptor for AGEs (RAGE) expression and PKC-alpha activation therefore; MK-I-81 reduces AGEs induced insulin resistance.	Isatin	25-31	protein kinase C, alpha	Mus musculus	129-138
26291733-0	2015	P(NMe2)3-mediated reductive [1+4] annulation of isatins with enones: a facile synthesis of spirooxindole-dihydrofurans.	Isatin	48-55	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	2-6
26291733-1	2015	A novel P(NMe2)3-mediated reductive [1+4] annulation reaction between isatins and enones has been developed, providing the facile synthesis of spirooxindole-dihydrofurans.	Isatin	70-77	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	10-14
26154082-1	2015	Screening a library of small-molecule compounds using a cell line expressing human GABA transporter 3 (hGAT3) in a [(3)H]GABA uptake assay identified isatin derivatives as a new class of hGAT3 inhibitors.	Isatin	150-156	solute carrier family 6 member 11	Homo sapiens	83-101
26154082-1	2015	Screening a library of small-molecule compounds using a cell line expressing human GABA transporter 3 (hGAT3) in a [(3)H]GABA uptake assay identified isatin derivatives as a new class of hGAT3 inhibitors.	Isatin	150-156	solute carrier family 6 member 11	Homo sapiens	103-108
26154082-1	2015	Screening a library of small-molecule compounds using a cell line expressing human GABA transporter 3 (hGAT3) in a [(3)H]GABA uptake assay identified isatin derivatives as a new class of hGAT3 inhibitors.	Isatin	150-156	solute carrier family 6 member 11	Homo sapiens	187-192
26408817-5	2015	Compounds 11e and 16e, with 5-NO2 substitution on the isatin ring, were found to be selective inhibitors of hCA IX and hCA XII.	Isatin	54-60	carbonic anhydrase 9	Homo sapiens	108-126
25891478-1	2015	Isatin is an endogenous inhibitor of monoamine oxidase B and is found in human blood and tissue.	Isatin	0-6	monoamine oxidase B	Homo sapiens	37-56
26288684-0	2015	Discovery of Novel Isatin-Based p53 Inducers.	Isatin	19-25	tumor protein p53	Homo sapiens	32-35
25630891-1	2015	The highly enantioselective organocatalytic addition of ethyl nitroacetate to isatin-derived N-Boc ketimines (Boc = tert-butoxycarbonyl), followed by the removal of the nitro group, is described.	Isatin	78-84	BOC cell adhesion associated, oncogene regulated	Homo sapiens	95-98
25955493-0	2015	Isatin based Schiff bases as inhibitors of alpha-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies.	Isatin	0-6	sucrase-isomaltase	Homo sapiens	43-60
25344147-1	2015	PURPOSE: We tested whether positron emission tomography (PET) with the caspase-3-targeted isatin analog [(18)F]WC-4-116 could image caspase-3 activation in response to an apoptosis-inducing anticancer therapy.	Isatin	90-96	caspase 3	Mus musculus	71-80
25344147-1	2015	PURPOSE: We tested whether positron emission tomography (PET) with the caspase-3-targeted isatin analog [(18)F]WC-4-116 could image caspase-3 activation in response to an apoptosis-inducing anticancer therapy.	Isatin	90-96	caspase 3	Mus musculus	132-141
25698234-7	2015	BNPPost also significantly phosphorylated Akt and p70s6k at early reperfusion, and Akt phosphorylation was inhibited by SH-6 and isatin.	Isatin	129-135	AKT serine/threonine kinase 1	Rattus norvegicus	83-86
25630891-1	2015	The highly enantioselective organocatalytic addition of ethyl nitroacetate to isatin-derived N-Boc ketimines (Boc = tert-butoxycarbonyl), followed by the removal of the nitro group, is described.	Isatin	78-84	BOC cell adhesion associated, oncogene regulated	Homo sapiens	110-113
25834908-0	2010	Development of the First CNS penetrant M5 Positive Allosteric Modulator (PAM) Based on a Novel, non-Isatin Core A recently completed functional, high throughput screen of the Molecular Libraries Probe Production Centers Network (MLPCN) screening deck of ~360,000 compounds conducted by SRIMSC against three of the five muscarinic receptor subtypes (M1, M4 and M5) provided a number of interesting hits.	Isatin	100-106	cholinergic receptor muscarinic 5	Homo sapiens	39-41
25834908-2	2010	The most promising M5 PAM hit (CID 17516658), being particularly attractive due to the absence of the isatin core shared by all previous M5 PAMs, was quickly developed into a potent, selective and CNS penetrant probe molecule ML380 (hM5 PAM EC50 = 190 nM, hM5 ACh fold-shift = 9.3, rM5 PAM EC50 = 610 nM).	Isatin	102-108	cholinergic receptor muscarinic 5	Homo sapiens	19-21
32287446-1	2015	Sulfonated-beta-cyclodextrin (beta-CD-SO3H) promoted efficient and fast electrophilic substitution reaction of indoles with various isatins reflux in water is reported affording various 3-indolyl-3-hydroxy oxindoles and 3,3-di(indolyl)indolin-2-ones in good to excellent yields in short reaction time.	Isatin	132-139	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	30-37
25174967-7	2014	Furthermore, Bcl-2 expression was decreased and the ratio of Bcl-2 to Bax was significantly decreased by isatin.	Isatin	105-111	BCL2 apoptosis regulator	Homo sapiens	13-18
24890564-2	2014	Structure-based virtual screening of about 3,000,000 commercially available compounds against the crystal structure of the glycosyltransferase (GT) domain of the Staphylococcus aureus penicillin-binding protein 2 (S. aureus PBP2) resulted in identification of an isatin derivative, 2-(3-(2-carbamimidoylhydrazono)-2-oxoindolin-1-yl)-N-(m-tolyl)acetamide (4) as a novel potential GT inhibitor.	Isatin	263-269	AT695_RS10295	Staphylococcus aureus	184-212
25174967-7	2014	Furthermore, Bcl-2 expression was decreased and the ratio of Bcl-2 to Bax was significantly decreased by isatin.	Isatin	105-111	BCL2 apoptosis regulator	Homo sapiens	61-66
25174967-7	2014	Furthermore, Bcl-2 expression was decreased and the ratio of Bcl-2 to Bax was significantly decreased by isatin.	Isatin	105-111	BCL2 associated X, apoptosis regulator	Homo sapiens	70-73
25174967-8	2014	The mitochondrial transmembrane potential was markedly decreased and the release of cytochrome c into the cytosol was elevated following treatment with isatin.	Isatin	152-158	cytochrome c, somatic	Homo sapiens	84-96
23247010-1	2013	Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous inhibitor of monoamine oxidases.	Isatin	204-210	carbonyl reductase 1	Homo sapiens	10-30
25046380-5	2014	As many PAC-1 derivatives contain a zinc chelating ortho-hydroxy N-acyl hydrazone moiety and isatin derivatives has two carbonyl groups on the indole core, it was of interest to determine to which extent these compounds can inhibit MMPs.	Isatin	93-99	dual specificity phosphatase 2	Homo sapiens	8-13
25046380-6	2014	METHODS: Eight PAC-1 and five isatin derivatives were docked into MMP-9 and MMP-14.	Isatin	30-36	matrix metallopeptidase 9	Homo sapiens	66-71
25046380-6	2014	METHODS: Eight PAC-1 and five isatin derivatives were docked into MMP-9 and MMP-14.	Isatin	30-36	matrix metallopeptidase 14	Homo sapiens	76-82
24051284-1	2014	Complexes of manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) with a Schiff base, formed by the condensation of isatin with 2-aminopyrimidine have been synthesised and characterised through elemental analysis, molar conductance measurements, magnetic susceptibility, IR, UV-Vis, (1)HNMR, FAB mass and EPR spectral studies.	Isatin	126-132	FA complementation group B	Homo sapiens	302-305
23522833-1	2013	Cu(OTf)2 catalyzed efficient synthesis of spiropyrano[3,2-b]pyran-4(8H)-ones is accomplished via one-pot three component reaction between isatin, kojic acid and active methylenes.	Isatin	138-144	POU class 2 homeobox 2	Homo sapiens	0-8
23376416-9	2013	Furthermore, Bcl-2 expression was decreased and the ratio of Bcl-2 to Bax was significantly decreased by isatin.	Isatin	105-111	BCL2 apoptosis regulator	Homo sapiens	13-18
23376416-9	2013	Furthermore, Bcl-2 expression was decreased and the ratio of Bcl-2 to Bax was significantly decreased by isatin.	Isatin	105-111	BCL2 apoptosis regulator	Homo sapiens	61-66
23376416-9	2013	Furthermore, Bcl-2 expression was decreased and the ratio of Bcl-2 to Bax was significantly decreased by isatin.	Isatin	105-111	BCL2 associated X, apoptosis regulator	Homo sapiens	70-73
23376416-10	2013	The mitochondrial transmembrane potential was markedly reduced and the release of cytochrome c into the cytosol was increased after treatment with isatin.	Isatin	147-153	cytochrome c, somatic	Homo sapiens	82-94
24917679-3	2014	Isatin hydrolase converts isatin to isatinate and belongs to a novel family of metalloenzymes that include the bacterial kynurenine formamidase.	Isatin	26-32	arylformamidase	Homo sapiens	121-143
25108055-8	2014	CRF 9-41, antalarmin, astressin 2B haloperidol, atropine, noraminophenazone and isatin prevented the NmU-induced increase in colon temperature.	Isatin	80-86	neuromedin U	Rattus norvegicus	101-104
24316276-0	2014	Inhibition of tumor necrosis factor-alpha and cyclooxigenase-2 by Isatin: a molecular mechanism of protection against TNBS-induced colitis in rats.	Isatin	66-72	tumor necrosis factor	Rattus norvegicus	14-41
24316276-6	2014	Our main results showed that the oral treatment with Isatin 6 and 25 mg/kg were capable of avoiding the increase in TNF-alpha, COX-2 and PGE2 levels when compared to the colitic non-treated group.	Isatin	53-59	tumor necrosis factor	Rattus norvegicus	116-125
24316276-6	2014	Our main results showed that the oral treatment with Isatin 6 and 25 mg/kg were capable of avoiding the increase in TNF-alpha, COX-2 and PGE2 levels when compared to the colitic non-treated group.	Isatin	53-59	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	127-132
23247010-1	2013	Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous inhibitor of monoamine oxidases.	Isatin	204-210	carbonyl reductase 1	Homo sapiens	32-36
23247010-1	2013	Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous inhibitor of monoamine oxidases.	Isatin	204-210	carbonyl reductase 1	Homo sapiens	38-45
23053004-5	2013	Obtained biological data could be well interpreted using docking binding energies toward vascular endothelial growth factor receptor (VEGFR-2); a key anticancer target being biologically investigated against various isatin derivatives.	Isatin	216-222	kinase insert domain receptor	Homo sapiens	134-141
23995665-5	2013	AKR1C5 also reduced various non-steroidal carbonyl compounds, including isatin, an antagonist of the C-type natriuretic peptide receptor, and 4-oxo-2-nonenal, suggesting its roles in controlling the bioactive isatin and detoxification of cytotoxic aldehydes.	Isatin	72-78	prostaglandin-E(2) 9-reductase	Oryctolagus cuniculus	0-6
23995665-5	2013	AKR1C5 also reduced various non-steroidal carbonyl compounds, including isatin, an antagonist of the C-type natriuretic peptide receptor, and 4-oxo-2-nonenal, suggesting its roles in controlling the bioactive isatin and detoxification of cytotoxic aldehydes.	Isatin	209-215	prostaglandin-E(2) 9-reductase	Oryctolagus cuniculus	0-6
23207410-4	2013	Moreover, partial recovery of MAO-B activity was observed after repeated washing in the presence of isatin (reversible inhibitor) and compounds 3g and 3h suggesting a reversible inhibition of the enzyme.	Isatin	100-106	monoamine oxidase B	Homo sapiens	30-35
21920762-0	2011	Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway.	Isatin	56-62	AKT serine/threonine kinase 1	Homo sapiens	120-123
24185378-4	2013	Generally in both series it was found that, compounds bearing no substituent or with 5"-F, 5"-Cl, 7"-Cl substitutents on the isatin moiety exhibited good inhibition against histone-H3 and histone-H4 deacetylation at the concentrations of 1 muM, as evaluated by Western Blot assay.	Isatin	125-131	latexin	Homo sapiens	240-243
24185378-8	2013	These findings should encourage further elaboration with the isatin moiety to produce more potent HDAC inhibitors with potential anticancer activity.	Isatin	61-67	histone deacetylase 9	Homo sapiens	98-102
23557234-3	2013	The 5 isatin concentrations evaluated in the mutagenicity and apoptosis tests were 0.5, 1, 5, 10, and 50 muM, selected through a preliminary MTT assay.	Isatin	6-12	latexin	Homo sapiens	105-108
21778064-1	2011	Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B.	Isatin	24-30	monoamine oxidase A	Homo sapiens	117-148
21838297-3	2011	Virtual screening analysis inspired the evaluation of 19 commercially available isatin analogues and 13 newly synthesized isatin derivatives as novel AHAS inhibitors and for their herbicidal activity.	Isatin	80-86	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	150-154
21838297-3	2011	Virtual screening analysis inspired the evaluation of 19 commercially available isatin analogues and 13 newly synthesized isatin derivatives as novel AHAS inhibitors and for their herbicidal activity.	Isatin	122-128	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	150-154
21838297-7	2011	This is the first comprehensive study of isatin derivatives as AHAS inhibitors and provides a valuable starting point for the design of new herbicides.	Isatin	41-47	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	63-67
21778064-1	2011	Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B.	Isatin	65-71	monoamine oxidase A	Homo sapiens	117-148
21778064-2	2011	In general, C5- and C6-substitution of isatin leads to enhanced binding affinity to both MAO isozymes compared to isatin and in most instances result in selective binding to the MAO-B isoform.	Isatin	39-45	monoamine oxidase B	Homo sapiens	178-183
21778064-3	2011	Crystallographic and modeling studies suggest that the isatin ring binds to the substrate cavities of MAO-A and -B and is stabilized by hydrogen bond interactions between the NH and the C2 carbonyl oxygen of the dioxoindolyl moiety and water molecules present in the substrate cavities of MAO-A and -B.	Isatin	55-61	monoamine oxidase A	Homo sapiens	102-114
21778064-3	2011	Crystallographic and modeling studies suggest that the isatin ring binds to the substrate cavities of MAO-A and -B and is stabilized by hydrogen bond interactions between the NH and the C2 carbonyl oxygen of the dioxoindolyl moiety and water molecules present in the substrate cavities of MAO-A and -B.	Isatin	55-61	monoamine oxidase A	Homo sapiens	289-301
20651027-7	2010	Both relaxation and cGMP accumulation after uroguanylin stimulation were blocked by the putative particulate guanylyl cyclase type C inhibitors 2-chloro-ATP and isatin (1H-indole-2,3-dione), but not by the soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-A]quinoxalin-1-one (ODQ).	Isatin	161-167	guanylate cyclase activator 2B	Homo sapiens	44-55
21615156-2	2011	One very promising PET tracer is (S)-1-(4-(2-[(18)F]-fluoroethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (isatin), a caspase-3 inhibitor, which has been developed at the University Hospital of Munster to image cell death (apoptosis).	Isatin	117-123	caspase 3	Rattus norvegicus	136-145
21863743-4	2011	The inhibitory effects of ODC (a heme-dependent inhibitor of sGC) and isatin were non-additive suggesting that the inhibitory effect of isatin may involve the heme binding domain (possibly heme iron) and experiments with hemin revealed some isatin-dependent changes in its spectrum.	Isatin	136-142	ornithine decarboxylase 1	Homo sapiens	26-29
21863743-4	2011	The inhibitory effects of ODC (a heme-dependent inhibitor of sGC) and isatin were non-additive suggesting that the inhibitory effect of isatin may involve the heme binding domain (possibly heme iron) and experiments with hemin revealed some isatin-dependent changes in its spectrum.	Isatin	136-142	ornithine decarboxylase 1	Homo sapiens	26-29
21863743-5	2011	Isatin also inhibited sGC activation by the allosteric activator YC-1.	Isatin	0-6	sarcoglycan beta	Homo sapiens	22-25
21863743-5	2011	Isatin also inhibited sGC activation by the allosteric activator YC-1.	Isatin	0-6	RNA binding motif single stranded interacting protein 1	Homo sapiens	65-69
21863743-6	2011	It is suggested that the bell shaped inhibition of the NO-dependent activation of sGC by isatin may be attributed to complex interaction of isatin with the heme binding domain and the allosteric YC-1-binding site of sGC.	Isatin	89-95	sarcoglycan beta	Homo sapiens	82-85
21863743-6	2011	It is suggested that the bell shaped inhibition of the NO-dependent activation of sGC by isatin may be attributed to complex interaction of isatin with the heme binding domain and the allosteric YC-1-binding site of sGC.	Isatin	89-95	RNA binding motif single stranded interacting protein 1	Homo sapiens	195-199
21863743-6	2011	It is suggested that the bell shaped inhibition of the NO-dependent activation of sGC by isatin may be attributed to complex interaction of isatin with the heme binding domain and the allosteric YC-1-binding site of sGC.	Isatin	89-95	sarcoglycan beta	Homo sapiens	216-219
21863743-6	2011	It is suggested that the bell shaped inhibition of the NO-dependent activation of sGC by isatin may be attributed to complex interaction of isatin with the heme binding domain and the allosteric YC-1-binding site of sGC.	Isatin	140-146	sarcoglycan beta	Homo sapiens	82-85
21134756-5	2011	The C5-substituted isatins exhibited higher binding affinities to MAO-B than the corresponding C6-substituted homologues.	Isatin	19-26	monoamine oxidase B	Homo sapiens	66-71
21134756-6	2011	The most potent MAO-B inhibitor, 5-(4-phenylbutyl)isatin, exhibited an IC(50) value of 0.66nM, approximately 13-fold more potent than (E)-5-styrylisatin and 18,500-fold more potent than isatin.	Isatin	50-56	monoamine oxidase B	Homo sapiens	16-21
21134756-8	2011	The results document that substitution at C5 with a variety of substituents is a general strategy for enhancing the MAO-B inhibition potency of isatin.	Isatin	144-150	monoamine oxidase B	Homo sapiens	116-121
21134756-9	2011	Possible binding orientations of selected isatin analogues within the active site cavities of MAO-A and MAO-B are proposed.	Isatin	42-48	monoamine oxidase A	Homo sapiens	94-99
21134756-9	2011	Possible binding orientations of selected isatin analogues within the active site cavities of MAO-A and MAO-B are proposed.	Isatin	42-48	monoamine oxidase B	Homo sapiens	104-109
21441025-0	2011	Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay.	Isatin	28-34	caspase 3	Homo sapiens	46-55
21441025-1	2011	A series of isatin analogs containing a hydrophilic group, including a pyridine ring, ethylene glycol group, and a triazole ring, have been synthesized, and their inhibition potency for caspase-3 was measured both in vitro (i.e., recombinant enzyme) and in whole cells (HeLa cells).	Isatin	12-18	caspase 3	Homo sapiens	186-195
21073954-5	2011	Isatin inhibited the relaxation to ANP both in arteries with and without endothelium.	Isatin	0-6	natriuretic peptides A	Oryctolagus cuniculus	35-38
20651027-7	2010	Both relaxation and cGMP accumulation after uroguanylin stimulation were blocked by the putative particulate guanylyl cyclase type C inhibitors 2-chloro-ATP and isatin (1H-indole-2,3-dione), but not by the soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-A]quinoxalin-1-one (ODQ).	Isatin	169-188	guanylate cyclase activator 2B	Homo sapiens	44-55
19900583-1	2010	Isatin, an endogenous indole compound, prevents atrial natriuretic peptide (ANP) from signaling through its cell-surface receptor, NPRA.	Isatin	0-6	natriuretic peptide receptor 1	Mus musculus	131-135
19900583-4	2010	Isatin nanocapsules reduced lung pathology by blocking ANP signaling, but surprisingly also by reducing the expression of NPRA.	Isatin	0-6	natriuretic peptide receptor 1	Mus musculus	122-126
19900583-5	2010	Ovalbumin-allergic mice were treated intranasally with isatin-containing chitosan nanocapsules either before or after allergen challenge, and lung function, cytokine levels, histopathology and cellular infiltration were determined.	Isatin	55-61	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	0-9
19900583-8	2010	Isatin nanocapsules administered locally to the lung reduced cGMP production and NPRA expression and protected allergic mice from airway hyperreactivity and lung inflammation when given either before or after allergen challenge.	Isatin	0-6	natriuretic peptide receptor 1	Mus musculus	81-85
19900583-10	2010	Isatin nanocapsules administered locally to the lung inhibit NPRA signaling but also are capable of lowering the expression of NPRA, thus effectively reducing inflammation in a mouse model of allergic asthma.	Isatin	0-6	natriuretic peptide receptor 1	Mus musculus	61-65
19900583-10	2010	Isatin nanocapsules administered locally to the lung inhibit NPRA signaling but also are capable of lowering the expression of NPRA, thus effectively reducing inflammation in a mouse model of allergic asthma.	Isatin	0-6	natriuretic peptide receptor 1	Mus musculus	127-131
21328918-4	2010	In both cases cytokeratin binding with the immobilized isatin analogues was characterized by rather high affinity (Kd of 0.7 microM for the pair CK14/immobilized 5-aminocaproylisatin and 1.7 microM for the pair CK8/immobilized 5-aminoisatin).	Isatin	55-61	keratin 14	Homo sapiens	145-149
21328918-4	2010	In both cases cytokeratin binding with the immobilized isatin analogues was characterized by rather high affinity (Kd of 0.7 microM for the pair CK14/immobilized 5-aminocaproylisatin and 1.7 microM for the pair CK8/immobilized 5-aminoisatin).	Isatin	55-61	keratin 8	Homo sapiens	211-214
19841672-5	2009	Screening of a focused xenobiotic compound library revealed that CBR3 has narrower substrate specificity and acts on several orthoquinones, as well as isatin or the anticancer drug oracin.	Isatin	151-157	carbonyl reductase 3	Homo sapiens	65-69
19854048-1	2009	A novel series of isatin-based inhibitors of beta-secretase (BACE-1) have been identified using a virtual high-throughput screening approach.	Isatin	18-24	beta-secretase 1	Homo sapiens	61-67
19910509-7	2009	Isatin, a specific ANP receptor antagonist, reversed ANP"s effect.	Isatin	0-6	natriuretic peptide A	Homo sapiens	19-22
19910509-7	2009	Isatin, a specific ANP receptor antagonist, reversed ANP"s effect.	Isatin	0-6	natriuretic peptide A	Homo sapiens	53-56
19397322-5	2009	The MDR1-selective pharmacophore highlights the importance of aromatic/hydrophobic features at the N4 position of the thiosemicarbazone and the reliance on the isatin moiety as key bioisosteric contributors.	Isatin	160-166	ATP binding cassette subfamily B member 1	Homo sapiens	4-8
19651509-0	2009	Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.	Isatin	0-6	transthyretin	Homo sapiens	37-50
19651509-1	2009	The isatin core structure was found to be a novel chemical scaffold in transthyretin (TTR) fibrillogenesis inhibitor design.	Isatin	4-10	transthyretin	Homo sapiens	71-84
19651509-1	2009	The isatin core structure was found to be a novel chemical scaffold in transthyretin (TTR) fibrillogenesis inhibitor design.	Isatin	4-10	transthyretin	Homo sapiens	86-89
19647171-2	2009	Radiolabeled isatins bind to caspase-3 with high affinity and are potential tracers for use with positron emission tomography to image apoptosis.	Isatin	13-20	caspase 3	Rattus norvegicus	29-38
19647171-3	2009	We compared the ability of two novel radiolabeled isatins, [18F]WC-IV-3 and [11C]WC-98, to detect caspase-3 activation in a rat model of cycloheximide-induced liver injury.	Isatin	50-57	caspase 3	Rattus norvegicus	98-107
19115816-2	2009	Here, we describe a novel series of selective CB2 inverse agonists resulting from introduction of a methoxy moiety in position 6 of the isatin scaffold.	Isatin	136-142	cannabinoid receptor 2	Homo sapiens	46-49
19342233-5	2009	Molecular docking studies with MAO-B indicate that the increased binding affinity exhibited by the (E)-styrylisatin analogues, in comparison to isatin, is best explained by the ability of the styrylisatins to bridge both the entrance cavity and the substrate cavity of the enzyme.	Isatin	109-115	monoamine oxidase B	Homo sapiens	31-36
19300818-11	2009	Therefore, this study provides a useful method for radio-synthesis of isatin derivative radiotracers for PET and SPECT studies, and [11C] 4 is a potential PET radiotracer for noninvasive imaging of apoptosis.	Isatin	70-76	thyroid stimulating hormone receptor	Mus musculus	105-108
19061875-8	2009	Towards isatin, wild-type CBR3 showed a catalytic efficiency of 0.018 microM(-1)min(-1), whereas wild-type CBR1 showed a catalytic efficiency of 13.5 microM(-1)min(-1).	Isatin	8-14	carbonyl reductase 3	Homo sapiens	26-30
19061875-8	2009	Towards isatin, wild-type CBR3 showed a catalytic efficiency of 0.018 microM(-1)min(-1), whereas wild-type CBR1 showed a catalytic efficiency of 13.5 microM(-1)min(-1).	Isatin	8-14	carbonyl reductase 1	Homo sapiens	107-111
19061875-9	2009	In particular, when nine residues (236-244) in the vicinity of the catalytic center and a proline (P230) in CBR3 were mutated to the corresponding residues of CBR1 a much higher k(cat)/K(m) value (5.7 microM(-1)min(-1)) towards isatin was observed.	Isatin	228-234	carbonyl reductase 3	Homo sapiens	108-112
19061875-9	2009	In particular, when nine residues (236-244) in the vicinity of the catalytic center and a proline (P230) in CBR3 were mutated to the corresponding residues of CBR1 a much higher k(cat)/K(m) value (5.7 microM(-1)min(-1)) towards isatin was observed.	Isatin	228-234	carbonyl reductase 1	Homo sapiens	159-163
19453193-2	2009	First, enantioselective arylation and alkenylation reactions of isatins using aryltrimethoxysilanes and alkenyltrimethoxysilanes as nucleophiles can be catalyzed by a complex of CuF with structurally tuned Taniaphos (6) in the presence of a catalytic amount of ZnF(2).	Isatin	64-71	zinc finger protein 2	Homo sapiens	261-267
19049429-0	2008	Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.	Isatin	78-84	caspase 3	Homo sapiens	56-65
18951902-6	2008	A molecule of l-proline was observed near the FAD, and this ligand superimposed well with isatin, a reversible inhibitor of MAO-B, when the structures of MAO-N proline and MAO-B-isatin were overlaid.	Isatin	90-96	monoamine oxidase B	Homo sapiens	124-129
18951902-6	2008	A molecule of l-proline was observed near the FAD, and this ligand superimposed well with isatin, a reversible inhibitor of MAO-B, when the structures of MAO-N proline and MAO-B-isatin were overlaid.	Isatin	90-96	monoamine oxidase B	Homo sapiens	172-177
18680359-2	2008	A focused library incorporating an isatin scaffold was designed and evaluated for inhibition of Shp2 and Shp1 PTP activities.	Isatin	35-41	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	96-100
18680359-2	2008	A focused library incorporating an isatin scaffold was designed and evaluated for inhibition of Shp2 and Shp1 PTP activities.	Isatin	35-41	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	105-109
18680359-2	2008	A focused library incorporating an isatin scaffold was designed and evaluated for inhibition of Shp2 and Shp1 PTP activities.	Isatin	35-41	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	110-113
15930748-7	2005	Thus, AKR1C19 possesses properties distinct from other members of the AKR superfamily, and may function as a reductase for endogenous isatin and xenobiotic alpha-dicarbonyl compounds in the liver and gastrointestinal tract.	Isatin	134-140	aldo-keto reductase family 1, member C19	Mus musculus	6-13
18988463-2	2008	Physiological concentrations of isatin inhibit natriuretic peptide (NPR) receptor binding and NPR-dependent signalling.	Isatin	32-38	neuronal pentraxin receptor	Rattus norvegicus	68-71
18988463-2	2008	Physiological concentrations of isatin inhibit natriuretic peptide (NPR) receptor binding and NPR-dependent signalling.	Isatin	32-38	neuronal pentraxin receptor	Rattus norvegicus	94-97
18988463-3	2008	The inhibition of NPR signalling by isatin is attenuated by a nonhydrolyzable ATP analogue.	Isatin	36-42	neuronal pentraxin receptor	Rattus norvegicus	18-21
18334118-6	2008	Along with the increase of ISA concentration, Bcl-2 expression was decreased, the ratio of Bcl-2 to Bax was significantly decreased (P<0.05).	Isatin	27-30	BCL2 apoptosis regulator	Homo sapiens	46-51
18334118-6	2008	Along with the increase of ISA concentration, Bcl-2 expression was decreased, the ratio of Bcl-2 to Bax was significantly decreased (P<0.05).	Isatin	27-30	BCL2 apoptosis regulator	Homo sapiens	91-96
18334118-6	2008	Along with the increase of ISA concentration, Bcl-2 expression was decreased, the ratio of Bcl-2 to Bax was significantly decreased (P<0.05).	Isatin	27-30	BCL2 associated X, apoptosis regulator	Homo sapiens	100-103
18334118-7	2008	When treated with ISA (100, 200, 400 micromol/L) for 48 h, the positive rates of activated Caspase-3 in SH-SY5Y cells were significantly higher than that in control SH-SY5Y cells (19.28%, 25.88%, and 33.43% vs. 10.58%, P<0.05).	Isatin	18-21	caspase 3	Homo sapiens	91-100
18334118-9	2008	In addition, the proportion of SH-SY5Y cells at G1 phase was significantly increased with an apparent G1 phase arrest when treated with ISA (100, 200, 400 micromol/L) for 48 h. In the progress of cell cycle arrest induced by ISA, phosphorylated ERK and CDK1 expression were down-regulated (P<0.05).	Isatin	136-139	mitogen-activated protein kinase 1	Homo sapiens	245-248
18334118-9	2008	In addition, the proportion of SH-SY5Y cells at G1 phase was significantly increased with an apparent G1 phase arrest when treated with ISA (100, 200, 400 micromol/L) for 48 h. In the progress of cell cycle arrest induced by ISA, phosphorylated ERK and CDK1 expression were down-regulated (P<0.05).	Isatin	136-139	cyclin dependent kinase 1	Homo sapiens	253-257
18334118-9	2008	In addition, the proportion of SH-SY5Y cells at G1 phase was significantly increased with an apparent G1 phase arrest when treated with ISA (100, 200, 400 micromol/L) for 48 h. In the progress of cell cycle arrest induced by ISA, phosphorylated ERK and CDK1 expression were down-regulated (P<0.05).	Isatin	225-228	mitogen-activated protein kinase 1	Homo sapiens	245-248
18334118-9	2008	In addition, the proportion of SH-SY5Y cells at G1 phase was significantly increased with an apparent G1 phase arrest when treated with ISA (100, 200, 400 micromol/L) for 48 h. In the progress of cell cycle arrest induced by ISA, phosphorylated ERK and CDK1 expression were down-regulated (P<0.05).	Isatin	225-228	cyclin dependent kinase 1	Homo sapiens	253-257
17761421-2	2007	A previous study of high-throughput drug screening identified an isatin derivative as a UCH-L3 inhibitor.	Isatin	65-71	ubiquitin C-terminal hydrolase L3	Homo sapiens	88-94
17649976-4	2007	In this article, we report the results of inhibition kinetics and binding studies utilizing fluorescence spectroscopy and isothermal titration calorimetry to characterize the mechanism of interaction of caspase-3 with three different classes of inhibitors: peptidomimetics, isatins, and pyrimidoindolones.	Isatin	274-281	caspase 3	Homo sapiens	203-212
17649976-7	2007	In contrast, the isatins bind to caspase-3 with significant heat release (-12 kcal/mol) and negative entropy.	Isatin	17-24	caspase 3	Homo sapiens	33-42
17141756-0	2007	Isatins inhibit cyclooxygenase-2 and inducible nitric oxide synthase in a mouse macrophage cell line.	Isatin	0-7	prostaglandin-endoperoxide synthase 2	Mus musculus	16-68
17141756-2	2007	We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO.	Isatin	52-58	interferon gamma	Mus musculus	93-109
17141756-2	2007	We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO.	Isatin	52-58	nitric oxide synthase 2, inducible	Mus musculus	132-163
17141756-2	2007	We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO.	Isatin	52-58	nitric oxide synthase 2, inducible	Mus musculus	165-169
17141756-2	2007	We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO.	Isatin	52-58	prostaglandin-endoperoxide synthase 2	Mus musculus	175-191
17141756-2	2007	We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO.	Isatin	52-58	prostaglandin-endoperoxide synthase 2	Mus musculus	193-198
17141756-2	2007	We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO.	Isatin	52-58	tumor necrosis factor	Mus musculus	272-293
17141756-2	2007	We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO.	Isatin	52-58	tumor necrosis factor	Mus musculus	295-304
17141756-3	2007	Isatins inhibit TNF-alpha production and iNOS and COX-2 protein expression resulting on reduced levels of NO and PGE(2).	Isatin	0-7	tumor necrosis factor	Mus musculus	16-25
17141756-3	2007	Isatins inhibit TNF-alpha production and iNOS and COX-2 protein expression resulting on reduced levels of NO and PGE(2).	Isatin	0-7	nitric oxide synthase 2, inducible	Mus musculus	41-45
17141756-3	2007	Isatins inhibit TNF-alpha production and iNOS and COX-2 protein expression resulting on reduced levels of NO and PGE(2).	Isatin	0-7	prostaglandin-endoperoxide synthase 2	Mus musculus	50-55
17141756-4	2007	Our results indicate isatin and it derivatives as inhibitors of iNOS and COX-2 enzymes, which might be used as anti-inflammatory and antitumoral agents.	Isatin	21-27	nitric oxide synthase 2, inducible	Mus musculus	64-68
17141756-4	2007	Our results indicate isatin and it derivatives as inhibitors of iNOS and COX-2 enzymes, which might be used as anti-inflammatory and antitumoral agents.	Isatin	21-27	prostaglandin-endoperoxide synthase 2	Mus musculus	73-78
15876476-1	2005	Isatin is an endogenous indole that is increased in stress, inhibits monoamine oxidase (MAO) B and improves bradykinesia and striatal dopamine levels in rat models of Parkinson"s disease.	Isatin	0-6	monoamine oxidase B	Rattus norvegicus	69-94
18561913-9	2008	Expression of phosphorylated ERKs decreased, but the level of activated caspase-3 increased after treatment of Isatin.	Isatin	111-117	caspase 3	Homo sapiens	72-81
16891117-0	2006	Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis.	Isatin	67-73	caspase 3	Rattus norvegicus	93-102
15854583-2	2005	In the present study, we have demonstrated that atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) inhibited [3H]isatin binding to rat brain sections and isolated membrane fractions.	Isatin	132-138	natriuretic peptide A	Rattus norvegicus	48-74
15854583-2	2005	In the present study, we have demonstrated that atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) inhibited [3H]isatin binding to rat brain sections and isolated membrane fractions.	Isatin	132-138	natriuretic peptide C	Rattus norvegicus	85-111
15854583-2	2005	In the present study, we have demonstrated that atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) inhibited [3H]isatin binding to rat brain sections and isolated membrane fractions.	Isatin	132-138	natriuretic peptide C	Rattus norvegicus	113-116
15854583-3	2005	Isatin itself antagonised not only natriuretic peptide receptor type A (NPR-A) (ANP-stimulation of guanylyl cyclase) but also NPR-C (ANP and CNP mediated inhibition of adenylyl cyclase) signalling.	Isatin	0-6	natriuretic peptide receptor 1	Rattus norvegicus	35-70
15854583-3	2005	Isatin itself antagonised not only natriuretic peptide receptor type A (NPR-A) (ANP-stimulation of guanylyl cyclase) but also NPR-C (ANP and CNP mediated inhibition of adenylyl cyclase) signalling.	Isatin	0-6	natriuretic peptide receptor 1	Rattus norvegicus	72-77
15854583-3	2005	Isatin itself antagonised not only natriuretic peptide receptor type A (NPR-A) (ANP-stimulation of guanylyl cyclase) but also NPR-C (ANP and CNP mediated inhibition of adenylyl cyclase) signalling.	Isatin	0-6	natriuretic peptide receptor 3	Rattus norvegicus	126-131
15854583-3	2005	Isatin itself antagonised not only natriuretic peptide receptor type A (NPR-A) (ANP-stimulation of guanylyl cyclase) but also NPR-C (ANP and CNP mediated inhibition of adenylyl cyclase) signalling.	Isatin	0-6	natriuretic peptide C	Rattus norvegicus	141-144
15854583-4	2005	These results suggest that some [3H]isatin binding in the brain may be to NPR-A and NPR-C.	Isatin	36-42	natriuretic peptide receptor 1	Rattus norvegicus	74-79
15854583-4	2005	These results suggest that some [3H]isatin binding in the brain may be to NPR-A and NPR-C.	Isatin	36-42	natriuretic peptide receptor 3	Rattus norvegicus	84-89
15854583-5	2005	Competitive interactions between isatin and natriuretic peptides and their receptors give a possible explanation of the known anxiogenic effect of low doses of isatin, interacting at NPR-A, and the sedative effects of higher doses, antagonising respectively the anxiolytic effect of ANP and the anxiogenic effect of CNP.	Isatin	33-39	natriuretic peptide receptor 1	Rattus norvegicus	183-188
15854583-5	2005	Competitive interactions between isatin and natriuretic peptides and their receptors give a possible explanation of the known anxiogenic effect of low doses of isatin, interacting at NPR-A, and the sedative effects of higher doses, antagonising respectively the anxiolytic effect of ANP and the anxiogenic effect of CNP.	Isatin	33-39	natriuretic peptide C	Rattus norvegicus	316-319
15854583-5	2005	Competitive interactions between isatin and natriuretic peptides and their receptors give a possible explanation of the known anxiogenic effect of low doses of isatin, interacting at NPR-A, and the sedative effects of higher doses, antagonising respectively the anxiolytic effect of ANP and the anxiogenic effect of CNP.	Isatin	160-166	natriuretic peptide receptor 1	Rattus norvegicus	183-188
15854583-5	2005	Competitive interactions between isatin and natriuretic peptides and their receptors give a possible explanation of the known anxiogenic effect of low doses of isatin, interacting at NPR-A, and the sedative effects of higher doses, antagonising respectively the anxiolytic effect of ANP and the anxiogenic effect of CNP.	Isatin	160-166	natriuretic peptide C	Rattus norvegicus	316-319
15710600-3	2005	In contrast, the reversible competitive inhibitor isatin binds to all known MAO B and MAO A with similar affinities.	Isatin	50-56	monoamine oxidase B	Homo sapiens	76-81
15710600-3	2005	In contrast, the reversible competitive inhibitor isatin binds to all known MAO B and MAO A with similar affinities.	Isatin	50-56	monoamine oxidase A	Homo sapiens	86-91
15710600-8	2005	The human MAO B I199F mutant protein of MAO B binds to isatin (K(i) = 3 microM) but not to the three inhibitors listed above.	Isatin	55-61	monoamine oxidase B	Homo sapiens	10-15
15710600-8	2005	The human MAO B I199F mutant protein of MAO B binds to isatin (K(i) = 3 microM) but not to the three inhibitors listed above.	Isatin	55-61	monoamine oxidase B	Homo sapiens	40-45
15104251-2	2004	Its physiological role remains unclear but certain evidence exists, that it may share some regulatory properties with isatin, a known endogenous inhibitor of monoamine oxidase (MAO) type B (MAO-B).	Isatin	118-124	monoamine oxidase B	Rattus norvegicus	158-188
15628602-0	2004	[The effect of long-term administration of isatin and himantan to mice on sensitivity of brain monoamine oxidase B to inhibition by deprenyl in vivo and in vitro].	Isatin	43-49	monoamine oxidase B	Mus musculus	95-114
15628602-6	2004	In vitro inhibition of MAO B activity in mitochondria isolated from brain of mice treated with isatin or himantane was somewhat higher than in control mitochondria.	Isatin	95-101	monoamine oxidase B	Mus musculus	23-28
15276478-7	2004	The effect of hANP was completely blocked by isatin, a potent antagonist of NPR (p < 0.01 vs. hANP).	Isatin	45-51	natriuretic peptide A	Homo sapiens	14-18
15276478-7	2004	The effect of hANP was completely blocked by isatin, a potent antagonist of NPR (p < 0.01 vs. hANP).	Isatin	45-51	neuronal pentraxin receptor	Homo sapiens	76-79
15276478-7	2004	The effect of hANP was completely blocked by isatin, a potent antagonist of NPR (p < 0.01 vs. hANP).	Isatin	45-51	natriuretic peptide A	Homo sapiens	97-101
15279562-4	2004	The recent development of high level expression systems for producing recombinant human liver MAO A and MAO B in Pichia pastoris has facilitated the determination of the three dimensional crystal structures of MAO B (up to 1.7 angstroms resolution) in complex with different reversible (isatin, 1,4-diphenyl-2-butene) and irreversible inhibitors (pargyline, N-(2-aminoethyl)-p-chlorobenzamide, and trans-2-phenylcyclopropylamine).	Isatin	287-293	monoamine oxidase B	Homo sapiens	210-215
17191919-3	2005	In this work, a new disubstituted indigoid generation system was developed with a tryptophanase-deficient Escherichia coli strain as a host to express the human cytochrome P450 2A6 mutant L240C/N297Q, which catalyzes the oxidation of indole to isatin and indoxyl, which in turn react to generate indigoids.	Isatin	244-250	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	161-180
15104251-2	2004	Its physiological role remains unclear but certain evidence exists, that it may share some regulatory properties with isatin, a known endogenous inhibitor of monoamine oxidase (MAO) type B (MAO-B).	Isatin	118-124	monoamine oxidase B	Rattus norvegicus	190-195
11895568-3	2002	In this study the aim was to investigate the effects of isatin on thermoregulatory actions of PACAP-38, in rats.	Isatin	56-62	adenylate cyclase activating polypeptide 1	Rattus norvegicus	94-99
14697895-1	2004	We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum.	Isatin	53-59	monoamine oxidase A	Rattus norvegicus	75-92
14697895-1	2004	We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum.	Isatin	53-59	monoamine oxidase A	Rattus norvegicus	94-97
12480089-0	2003	Isatin, an endogenous MAO inhibitor, improves bradykinesia and dopamine levels in a rat model of Parkinson"s disease induced by Japanese encephalitis virus.	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	22-25
12480089-1	2003	Isatin, an endogenous monoamine oxidase (MAO) inhibitor, has an important role in the control of neurotransmitter concentration.	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	41-44
12189628-3	2002	Isatin acted as a rather selective monoamine oxidase B inhibitor, whereas 5-hydroxyoxindole was more selective monoamine oxidase A inhibitor, but it was less potent than that of 5-hydroxyisatin, a synthetic analogue of isatin.	Isatin	0-6	monoamine oxidase B	Rattus norvegicus	35-54
11895568-7	2002	injection of different doses of isatin (25-50 mg/kg) significantly decreased the hyperthermic effect of 1 microg PACAP-38 (icv.	Isatin	32-38	adenylate cyclase activating polypeptide 1	Rattus norvegicus	113-118
11895568-11	2002	CONCLUSION: The mechanisms that participate in the mediation of the PACAP-38-induced hyperthermia may be modified by isatin.	Isatin	117-123	adenylate cyclase activating polypeptide 1	Rattus norvegicus	68-73
11895568-12	2002	The capability of isatin to antagonize the hyperthermia induced by all members of the natriuretic peptide family and by PACAP-38 makes it unlikely to be acting directly on receptors for natriuretic peptides or on those for PACAP in these hyperthermic processes.	Isatin	18-24	adenylate cyclase activating polypeptide 1	Rattus norvegicus	120-125
11602237-1	2001	Isatin was a potent endogenous monoamine oxidase (MAO) inhibitor that is more active against MAO-B than MAO-A.	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	31-48
11602237-1	2001	Isatin was a potent endogenous monoamine oxidase (MAO) inhibitor that is more active against MAO-B than MAO-A.	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	50-53
11602237-1	2001	Isatin was a potent endogenous monoamine oxidase (MAO) inhibitor that is more active against MAO-B than MAO-A.	Isatin	0-6	monoamine oxidase B	Rattus norvegicus	93-98
11602237-1	2001	Isatin was a potent endogenous monoamine oxidase (MAO) inhibitor that is more active against MAO-B than MAO-A.	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	104-109
11665840-0	2001	Effects of isatin on atrial natriuretic peptide-mediated accumulation of cGMP and guanylyl cyclase activity of PC12 cells.	Isatin	11-17	natriuretic peptide A	Rattus norvegicus	21-47
11665840-1	2001	We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations.	Isatin	37-43	natriuretic peptide A	Rattus norvegicus	165-191
11665840-1	2001	We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations.	Isatin	37-43	natriuretic peptide A	Rattus norvegicus	193-196
11665840-1	2001	We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations.	Isatin	37-43	natriuretic peptide A	Rattus norvegicus	219-222
11665840-1	2001	We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations.	Isatin	45-61	natriuretic peptide A	Rattus norvegicus	165-191
11665840-1	2001	We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations.	Isatin	45-61	natriuretic peptide A	Rattus norvegicus	193-196
11665840-1	2001	We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations.	Isatin	45-61	natriuretic peptide A	Rattus norvegicus	219-222
11665840-2	2001	In the present study the effects of isatin on ANP-mediated accumulation of cGMP and guanylyl cyclase (GC) activity of PC12 cells were studied.	Isatin	36-42	natriuretic peptide A	Rattus norvegicus	46-49
11665840-3	2001	Isatin (0.1 mM) effectively inhibited ANP-stimulated GC-activity of broken cells but was nearly inactive in attenuating ANP-dependent accumulation of cGMP in intact PC12 cells.	Isatin	0-6	natriuretic peptide A	Rattus norvegicus	38-41
11665840-5	2001	Isatin caused a more pronounced reduction of ANP-dependent cGMP accumulation in cells grown in the presence of 10% embryonal calf serum (ECS) than in 0.5% ECS.	Isatin	0-6	natriuretic peptide A	Rattus norvegicus	45-48
11665840-6	2001	The data obtained suggest that, in intact cells, the manifestation of the isatin effect on ANP-mediated signal transduction may depend on intracellular factor(s), possibly interacting at the kinase domain.	Isatin	74-80	natriuretic peptide A	Rattus norvegicus	91-94
11389882-0	2001	Cyclic GMP excretion blocked by isatin administration under conditions of fluid overload.	Isatin	32-38	5'-nucleotidase, cytosolic II	Homo sapiens	7-10
10978188-5	2000	In general, indoles, indazoles, benzotriazoles, indolones, and isatins gave analogues with weaker NR1A/2B activity than the parent phenols, while benzimidazolones and benzimidazolinones gave equipotent or more potent analogues.	Isatin	63-70	thyroid hormone receptor beta	Homo sapiens	98-104
11086715-0	2000	Parallel synthesis of isatin-based serine protease inhibitors.	Isatin	22-28	coagulation factor II, thrombin	Homo sapiens	35-50
11113594-0	2000	The action of isatin (2,3-dioxoindole) an endogenous indole on brain natriuretic and C-type natriuretic peptide-induced facilitation of memory consolidation in passive-avoidance learning in rats.	Isatin	14-20	natriuretic peptide C	Rattus norvegicus	85-111
11113594-1	2000	Isatin is an endogenous indole which has been shown to counteract some of the effects of atrial natriuretic peptide (ANP) both in vitro and in vivo.	Isatin	0-6	natriuretic peptide A	Rattus norvegicus	89-115
11113594-8	2000	Isatin reduced the effect of both BNP and CNP; this was significant for its effect on BNP at 50 mg/kg and on CNP at both 10 and 50 mg/kg.	Isatin	0-6	natriuretic peptide B	Rattus norvegicus	34-37
11113594-8	2000	Isatin reduced the effect of both BNP and CNP; this was significant for its effect on BNP at 50 mg/kg and on CNP at both 10 and 50 mg/kg.	Isatin	0-6	natriuretic peptide C	Rattus norvegicus	42-45
11113594-8	2000	Isatin reduced the effect of both BNP and CNP; this was significant for its effect on BNP at 50 mg/kg and on CNP at both 10 and 50 mg/kg.	Isatin	0-6	natriuretic peptide B	Rattus norvegicus	86-89
11113594-8	2000	Isatin reduced the effect of both BNP and CNP; this was significant for its effect on BNP at 50 mg/kg and on CNP at both 10 and 50 mg/kg.	Isatin	0-6	natriuretic peptide C	Rattus norvegicus	109-112
11113594-9	2000	These results show that isatin can inhibit behavioural effects of BNP and CNP as well as ANP.	Isatin	24-30	natriuretic peptide B	Rattus norvegicus	66-69
11113594-9	2000	These results show that isatin can inhibit behavioural effects of BNP and CNP as well as ANP.	Isatin	24-30	natriuretic peptide C	Rattus norvegicus	74-77
11006132-4	2000	Acute treatment with 5-hydroxyoxindole and isatin reduced the activity of extracellular signal regulated protein kinases (ERKs) by 35% at 100 microM and ERK1 activity was strongly inhibited by 5-Hydroxyoxindole at 10 microM.	Isatin	43-49	mitogen-activated protein kinase 3	Homo sapiens	122-126
11006132-4	2000	Acute treatment with 5-hydroxyoxindole and isatin reduced the activity of extracellular signal regulated protein kinases (ERKs) by 35% at 100 microM and ERK1 activity was strongly inhibited by 5-Hydroxyoxindole at 10 microM.	Isatin	43-49	mitogen-activated protein kinase 3	Homo sapiens	153-157
11253400-3	2001	50 microM isatin it increased the amplitude of the population spike in the CA1 evoked by stimulation of stratum radiatum.	Isatin	10-16	carbonic anhydrase 1	Rattus norvegicus	75-78
10510318-4	1999	Also, AKR7A2 was found to exhibit a narrow substrate specificity, with activity being restricted to succinic semialdehyde (SSA), 2-nitrobenzaldehyde, pyridine-2-aldehyde, isatin, 1,2-naphthoquinone (1,2-NQ) and 9,10-phenanthrenequinone.	Isatin	171-177	aldo-keto reductase family 7 member A2	Homo sapiens	6-12
10774257-0	2000	[Pharmacological role of isatin, an endogenous MAO inhibitor].	Isatin	25-31	monoamine oxidase A	Rattus norvegicus	47-50
10774257-2	2000	I previously identified isatin as an endogenous inhibitor of monoamine oxidase (MAO) in the human urine and the brain of stroke-prone spontaneously hypertensive rats (SHRSP) using GC-MS. A single dose of isatin significantly increased norepinephrine (NE) and 5-hydroxytryptamine (5-HT) concentrations measured 2 h later in the various brain regions of normotensive Wistar Kyoto rats (WKY).	Isatin	24-30	monoamine oxidase A	Rattus norvegicus	80-83
11061215-3	2000	Among various isatin analogues with nearllanar structure selective MAO B inhibitors fit to 3D box of 8.5x5.1x1.8 A, whereas 3D box of 14.2x5.6x1.8 A accommodates selective MAO A inhibitors.	Isatin	14-20	monoamine oxidase B	Homo sapiens	67-72
11061215-3	2000	Among various isatin analogues with nearllanar structure selective MAO B inhibitors fit to 3D box of 8.5x5.1x1.8 A, whereas 3D box of 14.2x5.6x1.8 A accommodates selective MAO A inhibitors.	Isatin	14-20	monoamine oxidase A	Homo sapiens	172-177
11061215-7	2000	3D-QSAR with CoMFA of isatin and pirlindole analogues of MAO A and B revealed differences in the models of MAO A and B.	Isatin	22-28	monoamine oxidase A	Homo sapiens	57-62
9776316-5	1998	Furthermore, administration of either the benzodiazepine receptor agonist diazepam or the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine prevented the increase in urinary isatin excretion induced by acute food deprivation, whereas the dopamine-beta-hydroxylase inhibitor diethyldithiocarbamate proved ineffective.	Isatin	179-185	dopamine beta-hydroxylase	Rattus norvegicus	243-268
10629878-0	1999	[Effects of isatin, an endogenous MAO inhibitor, on dopamine (DA) and acetylcholine (ACh) concentrations in rats].	Isatin	12-18	monoamine oxidase A	Rattus norvegicus	34-37
10629878-1	1999	Isatin (indole-2,3-dione), an endogenous inhibitor of monoamine oxidase (MAO), has several physiological properties for stress and anxiety.	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	54-71
10629878-1	1999	Isatin (indole-2,3-dione), an endogenous inhibitor of monoamine oxidase (MAO), has several physiological properties for stress and anxiety.	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	73-76
10629878-1	1999	Isatin (indole-2,3-dione), an endogenous inhibitor of monoamine oxidase (MAO), has several physiological properties for stress and anxiety.	Isatin	8-24	monoamine oxidase A	Rattus norvegicus	54-71
10629878-1	1999	Isatin (indole-2,3-dione), an endogenous inhibitor of monoamine oxidase (MAO), has several physiological properties for stress and anxiety.	Isatin	8-24	monoamine oxidase A	Rattus norvegicus	73-76
10093500-7	1998	Isatin is an endogenous anxiogenic factor which is also a potent inhibitor of the ANP receptor.	Isatin	0-6	natriuretic peptide A	Homo sapiens	82-85
9510091-0	1998	Determination of isatin, an endogenous monoamine oxidase inhibitor, in urine and tissues of rats by HPLC.	Isatin	17-23	monoamine oxidase A	Rattus norvegicus	39-56
9510091-2	1998	We have previously identified isatin as one of the endogenous monoamine oxidase (MAO) inhibitors in the urine and the brain of stroke-prone spontaneously hypertensive rats (SHRSP), using gas chromatography-mass spectrometry (GC-MS).	Isatin	30-36	monoamine oxidase A	Rattus norvegicus	62-79
9510091-2	1998	We have previously identified isatin as one of the endogenous monoamine oxidase (MAO) inhibitors in the urine and the brain of stroke-prone spontaneously hypertensive rats (SHRSP), using gas chromatography-mass spectrometry (GC-MS).	Isatin	30-36	monoamine oxidase A	Rattus norvegicus	81-84
9510091-9	1998	Isatin concentration correlated significantly and positively with endogenous MAO activity (tribulin-like activity) in both urine (r=0.924, P<0.001) and kidney extracts (r=0.862, P<0.01).	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	77-80
9536661-12	1998	The proconvulsant effect of isatin, may be due to its inhibitory effect on central atrial natriuretic peptide receptors and stimulation of 5-hydroxytryptamine3 (5-HT3) rather than its monoamine oxidase (MAO) B inhibitory action.	Isatin	28-34	monoamine oxidase B	Rattus norvegicus	184-209
9651105-6	1998	These results suggest that isatin antagonises the generation of second messenger by GC-A; this sensitivity might be regulated at an ATP binding site, possibly a protein kinase-like domain.	Isatin	27-33	grancalcin	Rattus norvegicus	84-88
9503568-4	1997	In vitro, isatin selectively inhibits monoamine oxidase (MAO) B (IC50 3-8 microM, Ki approximately 20 microM) and, more potently, atrial natriuretic peptide(ANP) binding (IC50, 0.4 microM).	Isatin	10-16	monoamine oxidase B	Homo sapiens	38-63
9564631-9	1998	Isatin is an endogenous selective inhibitor of MAO-B (K1 approximately 3 microM).	Isatin	0-6	monoamine oxidase B	Homo sapiens	47-52
9324239-1	1997	Isatin is a reversible endogenous monoamine oxidase (MAO) inhibitor found in the brain.	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	34-51
9324239-3	1997	In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg).	Isatin	27-33	monoamine oxidase A	Rattus norvegicus	201-206
9324239-1	1997	Isatin is a reversible endogenous monoamine oxidase (MAO) inhibitor found in the brain.	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	53-56
9324239-3	1997	In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg).	Isatin	27-33	monoamine oxidase B	Rattus norvegicus	211-216
9324239-2	1997	The influence of isatin on the degree of irreversible MAO inhibition by phenelzine and pargyline has been studied in vitro and in vivo experiments.	Isatin	17-23	monoamine oxidase A	Rattus norvegicus	54-57
9324239-3	1997	In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg).	Isatin	165-171	monoamine oxidase A	Rattus norvegicus	69-74
9324239-3	1997	In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg).	Isatin	165-171	monoamine oxidase B	Rattus norvegicus	79-84
9324239-3	1997	In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg).	Isatin	27-33	monoamine oxidase A	Rattus norvegicus	69-74
9324239-3	1997	In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg).	Isatin	165-171	monoamine oxidase A	Rattus norvegicus	201-206
9324239-3	1997	In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg).	Isatin	165-171	monoamine oxidase B	Rattus norvegicus	211-216
9324239-3	1997	In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg).	Isatin	27-33	monoamine oxidase B	Rattus norvegicus	79-84
9324239-4	1997	"Anticonvulsant" dose of isatin (80 mg/kg) reduced phenelzine-dependent inhibition of MAO B but not MAO A.	Isatin	25-31	monoamine oxidase B	Rattus norvegicus	86-91
9148606-4	1996	Isatin is a selective inhibitor of monoamine oxidase B.	Isatin	0-6	monoamine oxidase B	Homo sapiens	35-54
9324239-4	1997	"Anticonvulsant" dose of isatin (80 mg/kg) reduced phenelzine-dependent inhibition of MAO B but not MAO A.	Isatin	25-31	monoamine oxidase A	Rattus norvegicus	100-105
8840356-4	1996	Isatin, an endogenous anxiogenic indole, shown to be an antagonist of ANP in vitro, significantly inhibited the anxiolytic effect of ANP in the elevated plus-maze test in subanxiogenic doses.	Isatin	0-6	natriuretic peptide A	Rattus norvegicus	70-73
8840356-4	1996	Isatin, an endogenous anxiogenic indole, shown to be an antagonist of ANP in vitro, significantly inhibited the anxiolytic effect of ANP in the elevated plus-maze test in subanxiogenic doses.	Isatin	0-6	natriuretic peptide A	Rattus norvegicus	133-136
8840356-7	1996	The data indicate that ANP may function as an endogenous anxiomodulator, which may act in conjunction with isatin independently of benzodiazepine receptors.	Isatin	107-113	natriuretic peptide A	Rattus norvegicus	23-26
9072455-11	1995	These data suggest that isatin, an endogenous MAO inhibitor, presents in the SHRSP brain and maintains high blood pressure.	Isatin	24-30	monoamine oxidase A	Rattus norvegicus	46-49
7753903-1	1995	Isatin is an endogenous selective inhibitor of monoamine oxidase (MAO) B, related to tribulin, whose activity and excretion in urine is increased during stress and anxiety.	Isatin	0-6	monoamine oxidase B	Rattus norvegicus	47-72
9072455-0	1995	Role of an endogenous monoamine oxidase inhibitor, isatin, in SHRSP brain.	Isatin	51-57	monoamine oxidase A	Rattus norvegicus	22-39
8543325-2	1995	Earlier studies have indicated that isatin functions as a 5-hydroxytryptamine (5-HT)3 receptor agonist in its anxiogenic activity in rats and is an antagonist at mammalian atrial natriuretic peptide (ANP) receptors.	Isatin	36-42	5-hydroxytryptamine receptor 3A	Rattus norvegicus	79-94
7663405-6	1995	The presence of hydroxy group at C5 of isatin increased selectivity of MAO-A inhibition, however simultaneous insertion of substituents into both positions of indole ring (5-hydroxy-2-phenylindole) led to a decrease of MAO-A inhibition.	Isatin	39-45	monoamine oxidase A	Homo sapiens	71-76
7663405-6	1995	The presence of hydroxy group at C5 of isatin increased selectivity of MAO-A inhibition, however simultaneous insertion of substituents into both positions of indole ring (5-hydroxy-2-phenylindole) led to a decrease of MAO-A inhibition.	Isatin	39-45	monoamine oxidase A	Homo sapiens	219-224
7786964-0	1995	CSF isatin is elevated in bulimia nervosa.	Isatin	4-10	colony stimulating factor 2	Homo sapiens	0-3
7829161-1	1994	Isatin (10 microM) strongly inhibited the activity of rat brain monoamine oxidase-B (MAO-B) in vitro.	Isatin	0-6	monoamine oxidase B	Rattus norvegicus	64-83
7475958-0	1995	Isatin is a potent endogenous antagonist of guanylate cyclase-coupled atrial natriuretic peptide receptors.	Isatin	0-6	natriuretic peptide A	Rattus norvegicus	70-96
7475958-3	1995	In the present study, we show that isatin has little effect on a wide range of neurotransmitter and hormonal receptors but that it acts as an inhibitor of atrial natriuretic peptide (ANP) binding, with an IC50 of 4x 10(-7) M. It also inhibits ANP-activated particulate guanylate cyclase from rat kidney, heart and brain membranes in dose-dependent fashion, varying also with ANP concentration.	Isatin	35-41	natriuretic peptide A	Rattus norvegicus	155-181
7475958-3	1995	In the present study, we show that isatin has little effect on a wide range of neurotransmitter and hormonal receptors but that it acts as an inhibitor of atrial natriuretic peptide (ANP) binding, with an IC50 of 4x 10(-7) M. It also inhibits ANP-activated particulate guanylate cyclase from rat kidney, heart and brain membranes in dose-dependent fashion, varying also with ANP concentration.	Isatin	35-41	natriuretic peptide A	Rattus norvegicus	183-186
7475958-3	1995	In the present study, we show that isatin has little effect on a wide range of neurotransmitter and hormonal receptors but that it acts as an inhibitor of atrial natriuretic peptide (ANP) binding, with an IC50 of 4x 10(-7) M. It also inhibits ANP-activated particulate guanylate cyclase from rat kidney, heart and brain membranes in dose-dependent fashion, varying also with ANP concentration.	Isatin	35-41	natriuretic peptide A	Rattus norvegicus	243-246
7475958-3	1995	In the present study, we show that isatin has little effect on a wide range of neurotransmitter and hormonal receptors but that it acts as an inhibitor of atrial natriuretic peptide (ANP) binding, with an IC50 of 4x 10(-7) M. It also inhibits ANP-activated particulate guanylate cyclase from rat kidney, heart and brain membranes in dose-dependent fashion, varying also with ANP concentration.	Isatin	35-41	natriuretic peptide A	Rattus norvegicus	243-246
7475958-4	1995	These findings suggest that isatin is a new endogenous regulator of mammalian ANP activity, with potential implications for the control of both anxiety and natriuresis.	Isatin	28-34	natriuretic peptide A	Homo sapiens	78-81
8527006-2	1995	We have previously identified one of them, isatin, which is a selective inhibitor of MAO B.	Isatin	43-49	monoamine oxidase B	Homo sapiens	85-90
7829161-1	1994	Isatin (10 microM) strongly inhibited the activity of rat brain monoamine oxidase-B (MAO-B) in vitro.	Isatin	0-6	monoamine oxidase B	Rattus norvegicus	85-90
1510706-0	1992	Inhibitory potency of some isatin analogues on human monoamine oxidase A and B.	Isatin	27-33	monoamine oxidase A	Homo sapiens	53-78
1510706-1	1992	Isatin is an endogenous compound which acts as a selective inhibitor of monoamine oxidase (MAO) B.	Isatin	0-6	monoamine oxidase B	Homo sapiens	72-97
1510706-2	1992	In this study a range of isatin analogues were tested for their in vitro inhibition of human MAO A and B.	Isatin	25-31	monoamine oxidase A	Homo sapiens	93-104
1691454-1	1990	Isatin (Tribulin) produced a dose-dependent inhibition of both MAO A and MAO B in broken cell preparations from rat brain and pineal.	Isatin	0-6	monoamine oxidase A	Homo sapiens	63-68
1688707-0	1990	Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin.	Isatin	24-30	monoamine oxidase A	Rattus norvegicus	46-49
1688707-1	1990	A study of the acute effects of isatin, an endogenous MAO inhibitor related to tribulin, on rat brain serotonergic function was undertaken.	Isatin	32-38	monoamine oxidase A	Rattus norvegicus	54-57
1768136-5	1991	Isatin (indole-2,3-dione) was produced as an intermediate when the consortium was amended with oxindole, providing evidence that degradation of indole proceeded through successive hydroxylation of the 2- and 3-positions prior to ring cleavage between the C-2 and C-3 atoms on the pyrrole ring of indole.	Isatin	0-6	complement C2	Homo sapiens	255-266
1768136-5	1991	Isatin (indole-2,3-dione) was produced as an intermediate when the consortium was amended with oxindole, providing evidence that degradation of indole proceeded through successive hydroxylation of the 2- and 3-positions prior to ring cleavage between the C-2 and C-3 atoms on the pyrrole ring of indole.	Isatin	8-24	complement C2	Homo sapiens	255-266
1691454-1	1990	Isatin (Tribulin) produced a dose-dependent inhibition of both MAO A and MAO B in broken cell preparations from rat brain and pineal.	Isatin	0-6	monoamine oxidase B	Homo sapiens	73-78
1691454-5	1990	However, the diazepam augmentation of beta adrenergic induction of serotonin N-acetyltransferase activity was blocked by isatin.	Isatin	121-127	aralkylamine N-acetyltransferase	Rattus norvegicus	67-96
22033021-0	2012	Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody.	Isatin	13-19	caspase 3	Mus musculus	31-40
33764269-4	2021	To test this hypothesis, a total of 79 isatin derivatives, which inhibited Mpro activity under in vitro conditions, were selected from the literature, and then screened through AutoDock Vina.	Isatin	39-45	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	75-79
22033021-2	2012	We evaluated the ability of radiolabeled isatins to quantify caspase-3 activity induced by the activation of the extrinsic apoptotic pathway by the anti-Fas antibody in mice.	Isatin	41-48	caspase 3	Mus musculus	61-70
22033021-9	2012	The isatin [(18)F]WC-II-89 was retained at statistically significantly higher levels in the organs after anti-Fas antibody treatment while [(99m)Tc]mebrofenin activity cleared, suggesting specific binding to activated caspase-3, but the magnitude of increased binding was still relatively low.	Isatin	4-10	caspase 3	Mus musculus	218-227
22033021-11	2012	CONCLUSIONS: The radiolabeled isatins appear to bind specifically to caspase-3 in vivo, but their sensitivity is limited.	Isatin	30-37	caspase 3	Mus musculus	69-78
34530651-1	2021	The hybrid method of the Electron-Conformational Genetic Algorithm (EC-GA) was used to determine the pharmacophore groups and to estimate anticancer activity in isatin derivatives using a robust 4D-QSAR software (EMRE).	Isatin	161-167	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	213-217
34932350-2	2022	The proposed preferential mechanistic scenario here undergoes three major steps: first, 3-methyl-2-pyrazolin-5-one converts to its enol form and then, the aldol addition reaction takes place between isatin and enol to generate the intermediate INT2, followed finally by the tautomerization of INT2 to become the product 3-pyrazolone.	Isatin	199-205	fibroblast growth factor 3	Homo sapiens	244-248
34932350-2	2022	The proposed preferential mechanistic scenario here undergoes three major steps: first, 3-methyl-2-pyrazolin-5-one converts to its enol form and then, the aldol addition reaction takes place between isatin and enol to generate the intermediate INT2, followed finally by the tautomerization of INT2 to become the product 3-pyrazolone.	Isatin	199-205	fibroblast growth factor 3	Homo sapiens	293-297
34600331-3	2021	Herein, we report the novel and highly potent inhibitors of alpha-amylase and alpha-glucosidase, namely isatin-hydrazide conjugates 1a - 1j that are easily accessed in two steps from simple and inexpensive commercially available isatin.	Isatin	229-235	sucrase-isomaltase	Homo sapiens	78-95
34990933-4	2022	Both series yielded low micromolar selective inhibitors of human MAO-B, namely indole 2 (IC50 = 12.63 +- 1.21 microM) and piperazine 39 (IC50 = 19.25 +- 4.89 microM), which is comparable to selective MAO-B inhibitor isatin (IC50 = 6.10 +- 2.81 microM), yet less potent in comparison to safinamide (IC50 = 0.029 +- 0.002 microM).	Isatin	216-222	monoamine oxidase B	Homo sapiens	65-70
34990933-4	2022	Both series yielded low micromolar selective inhibitors of human MAO-B, namely indole 2 (IC50 = 12.63 +- 1.21 microM) and piperazine 39 (IC50 = 19.25 +- 4.89 microM), which is comparable to selective MAO-B inhibitor isatin (IC50 = 6.10 +- 2.81 microM), yet less potent in comparison to safinamide (IC50 = 0.029 +- 0.002 microM).	Isatin	216-222	monoamine oxidase B	Homo sapiens	200-205
34889095-1	2022	A cascade assembly between isatin-derived Morita-Baylis-Hillman carbonates and o-hydroxybenzylideneacetones has been developed under the relay catalysis of Pd(PPh3)4 and DBU, affording a spectrum of 1,2,3,4-tetrahydrodibenzo(b,d)furan architectures incorporating a spirooxindole motif in moderate to good yields with excellent diastereoselectivity.	Isatin	27-33	caveolin 1	Homo sapiens	159-163
34637598-4	2022	Enzyme kinetics studies revealed that the isatin-based carbohydrazones are reversible inhibitors for both FAAH and MAGL.	Isatin	42-48	fatty acid amide hydrolase	Homo sapiens	106-110
34637598-4	2022	Enzyme kinetics studies revealed that the isatin-based carbohydrazones are reversible inhibitors for both FAAH and MAGL.	Isatin	42-48	monoglyceride lipase	Homo sapiens	115-119
3392550-4	1988	Isatin is a potent inhibitor of MAO, particularly of MAO B (IC50, 3 microM), and also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 microM).	Isatin	0-6	monoamine oxidase B	Homo sapiens	53-58
35398259-7	2022	AKR1C1 and AKR1C4 also showed broad substrate specificity for nonsteroidal carbonyl compounds including endogenous 4-oxo-2-nonenal, 4-hydroxy-nonenal, acrolein, isocaproaldehyde, farnesal, isatin and methylglyoxal, of which 4-oxo-2-nonenal was reduced with the lowest Km value of 0.9microM.	Isatin	189-195	aldo-keto reductase family 1 member C1	Homo sapiens	0-6
35398259-7	2022	AKR1C1 and AKR1C4 also showed broad substrate specificity for nonsteroidal carbonyl compounds including endogenous 4-oxo-2-nonenal, 4-hydroxy-nonenal, acrolein, isocaproaldehyde, farnesal, isatin and methylglyoxal, of which 4-oxo-2-nonenal was reduced with the lowest Km value of 0.9microM.	Isatin	189-195	aldo-keto reductase family 1 member C4	Homo sapiens	11-17
35618489-6	2022	The 3D-QSAR model was developed using reported indole-2,3-diones based ALDH1A1 inhibitors, which provided field points in terms of electrostatic, van der Waals and hydrophobic potentials required for selectively inhibiting ALDH1A1.	Isatin	47-64	aldehyde dehydrogenase 1 family member A1	Homo sapiens	71-78
35618489-6	2022	The 3D-QSAR model was developed using reported indole-2,3-diones based ALDH1A1 inhibitors, which provided field points in terms of electrostatic, van der Waals and hydrophobic potentials required for selectively inhibiting ALDH1A1.	Isatin	47-64	aldehyde dehydrogenase 1 family member A1	Homo sapiens	223-230
35378040-3	2022	The two-step one-pot 1,6-conjugate addition provides effective access to a series of isatin-incorporated phosphate-bearing 1,6-adducts having two vicinal tertiary carbons with up to 90% yield and >20:1 dr.	Isatin	85-91	protection of telomeres 1	Homo sapiens	17-22
35453384-5	2022	Isatin ameliorated the deleterious effects of DENA/2-AAF on liver function as evidenced by reduced serum levels of AST, ALT, total bilirubin, albumin, and liver tumor biomarkers (CA19.9 and AFP) compared to control DENA/2-AAF-treated rats.	Isatin	0-6	alpha-fetoprotein	Rattus norvegicus	190-193
35453384-8	2022	Moreover, isatin significantly reduced the DENA/2-AAF-induced decrease in hepatic expression of anti-apoptotic Bcl2 and the DENA/2-AAF-induced increases in pro-inflammatory and pro-apoptotic factors (TNF-alpha, NF-kappaB p50, NF-kappaB p65, p53, and caspase 3).	Isatin	10-16	BCL2, apoptosis regulator	Rattus norvegicus	111-115
35453384-8	2022	Moreover, isatin significantly reduced the DENA/2-AAF-induced decrease in hepatic expression of anti-apoptotic Bcl2 and the DENA/2-AAF-induced increases in pro-inflammatory and pro-apoptotic factors (TNF-alpha, NF-kappaB p50, NF-kappaB p65, p53, and caspase 3).	Isatin	10-16	tumor necrosis factor	Rattus norvegicus	200-209
35453384-8	2022	Moreover, isatin significantly reduced the DENA/2-AAF-induced decrease in hepatic expression of anti-apoptotic Bcl2 and the DENA/2-AAF-induced increases in pro-inflammatory and pro-apoptotic factors (TNF-alpha, NF-kappaB p50, NF-kappaB p65, p53, and caspase 3).	Isatin	10-16	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	241-244
35453384-8	2022	Moreover, isatin significantly reduced the DENA/2-AAF-induced decrease in hepatic expression of anti-apoptotic Bcl2 and the DENA/2-AAF-induced increases in pro-inflammatory and pro-apoptotic factors (TNF-alpha, NF-kappaB p50, NF-kappaB p65, p53, and caspase 3).	Isatin	10-16	caspase 3	Rattus norvegicus	250-259
34310996-0	2021	Modification with N-benzylisatin restricts stress-induced aggregation of hen egg white lysozyme: Anti-amyloidogenic property of isatin derivative with possible clinical implications.	Isatin	128-134	lysozyme	Homo sapiens	87-95
35601305-3	2022	Isatin is an endogenous small fragment, reversible inhibitor for MAO enzymes and is more selective for MAO-B than -A.	Isatin	0-6	monoamine oxidase B	Homo sapiens	103-108
35601305-6	2022	Isatin has a polypharmacological profile in medicinal chemistry, is a reversible inhibitor for both the MAOs, and shows high selectivity potent inhibition for MAO-B.	Isatin	0-6	monoamine oxidase B	Homo sapiens	159-164
33540058-4	2021	For this, (3Z)-5-Chloro-3-(hydroxyimino)indolin-2-one (Cl-HIN), a compound that has properties of isatin and oxime in its structure, have shown reactivating properties in the activity of AChE that have been added to antidepressant-like effects in rats exposed to malathion in acute protocol.	Isatin	98-104	acetylcholinesterase	Rattus norvegicus	187-191
523344-1	1979	Qualitative and semiquantitative histochemical investigations of acetylcholinesterase after a single or repeated administration of isatin, 160 mg/kg ip once or daily for 8 consecutive days have revealed a significant decrease of the histochemical reaction for acetylcholinesterase in chronically treated rats.	Isatin	131-137	acetylcholinesterase	Rattus norvegicus	65-85
523344-1	1979	Qualitative and semiquantitative histochemical investigations of acetylcholinesterase after a single or repeated administration of isatin, 160 mg/kg ip once or daily for 8 consecutive days have revealed a significant decrease of the histochemical reaction for acetylcholinesterase in chronically treated rats.	Isatin	131-137	acetylcholinesterase	Rattus norvegicus	260-280
34022091-0	2021	Participation of glutamatergic and nitrergic systems in the striatal dopamine release induced by isatin, a MAO inhibitor.	Isatin	97-103	monoamine oxidase A	Rattus norvegicus	107-110
33684714-3	2021	In this regard, the present work aims at developing a new set of small molecules featuring the privileged isatin scaffold conjugated with a thiazolo[3,2-a]benzimidazole (TBI) motif through a cleavable hydrazide linker (7a-e and 10a-i) as potential anticancer CDK2 inhibitors.	Isatin	106-112	cyclin dependent kinase 2	Homo sapiens	259-263
33506699-1	2021	Aim: Keeping in view the side effects associated with clinically used alpha-glucosidase inhibitors, novel thiazolidinedione-isatin hybrids were synthesized and evaluated by in vitro, in vivo and in silico procedures.	Isatin	124-130	sucrase-isomaltase	Homo sapiens	70-87
33367935-3	2021	Mechanistically, isatin inhibited lysine-specific histone demethylase (LSD)1 and reversed the blockade on p53, thereby activating the apoptotic pathway.	Isatin	17-23	lysine demethylase 1A	Homo sapiens	50-76
33645522-0	2021	[Changes in the mitochondrial subproteome of mouse brain Rpn13-binding proteins induced by the neurotoxin MPTP and the neuroprotector isatin].	Isatin	134-140	adhesion regulating molecule 1	Mus musculus	57-62
33645522-5	2021	In this study we have investigated the effect of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and the neuroprotector isatin on the mitochondrial subproteome of Rpn13-binding proteins of the mouse brain.	Isatin	139-145	adhesion regulating molecule 1	Mus musculus	182-187
33645522-7	2021	At the same time, the injection of MPTP, isatin, or their combination (isatin + MPTP) had a significant impact on the total number and the composition of Rpn13-binding proteins.	Isatin	41-47	adhesion regulating molecule 1	Mus musculus	154-159
33645522-7	2021	At the same time, the injection of MPTP, isatin, or their combination (isatin + MPTP) had a significant impact on the total number and the composition of Rpn13-binding proteins.	Isatin	71-77	adhesion regulating molecule 1	Mus musculus	154-159
33645522-8	2021	The injection of MPTP decreased the total number of Rpn13-binding proteins in comparison with control, and the injection of isatin prior to MPTP or without MPTP caused an essential increase in the number of Rpn13-binding proteins, mainly of the functional group of proteins participating in the protein metabolism regulation, gene expression, and differentiation.	Isatin	124-130	adhesion regulating molecule 1	Mus musculus	52-57
33645522-8	2021	The injection of MPTP decreased the total number of Rpn13-binding proteins in comparison with control, and the injection of isatin prior to MPTP or without MPTP caused an essential increase in the number of Rpn13-binding proteins, mainly of the functional group of proteins participating in the protein metabolism regulation, gene expression, and differentiation.	Isatin	124-130	adhesion regulating molecule 1	Mus musculus	207-212
33367935-3	2021	Mechanistically, isatin inhibited lysine-specific histone demethylase (LSD)1 and reversed the blockade on p53, thereby activating the apoptotic pathway.	Isatin	17-23	tumor protein p53	Homo sapiens	106-109
33367935-4	2021	The inhibitory effect of isatin on LSD1 may be mediated via direct binding and molecular docking or indirectly through the TGFbeta/ERK/NF-kappaB signaling pathway.	Isatin	25-31	lysine demethylase 1A	Homo sapiens	35-39
33367935-4	2021	The inhibitory effect of isatin on LSD1 may be mediated via direct binding and molecular docking or indirectly through the TGFbeta/ERK/NF-kappaB signaling pathway.	Isatin	25-31	mitogen-activated protein kinase 1	Homo sapiens	131-134
33367935-4	2021	The inhibitory effect of isatin on LSD1 may be mediated via direct binding and molecular docking or indirectly through the TGFbeta/ERK/NF-kappaB signaling pathway.	Isatin	25-31	nuclear factor kappa B subunit 1	Homo sapiens	135-144
33200681-0	2022	Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (mpro): a molecular docking, molecular dynamics and structure-activity relationship studies.	Isatin	47-53	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	100-104
33308120-10	2022	RESULTS: Three compounds 12d, 12e and 12h with propionyl and butyroyl linker between amine and isatin Schiff base scaffold have shown potent acetyl and butyryl cholinesterase inhibitory activity.	Isatin	95-101	butyrylcholinesterase	Homo sapiens	160-174
33200681-5	2022	Molecular docking analysis against Mpro protein were performed finding isatin linked with a oxidiazoles (A2 and A4) derivatives to have the best docking scores of -11.22 kcal/mol and -11.15 kcal/mol respectively.	Isatin	71-77	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	35-39
32304702-1	2020	Isatin is an endogenous indole that inhibits monoamine oxidase (MAO).	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	45-62
33066693-0	2020	Mechanism of the Affinity-Enhancing Effect of Isatin on Human Ferrochelatase and Adrenodoxin Reductase Complex Formation: Implication for Protein Interactome Regulation.	Isatin	46-52	ferrochelatase	Homo sapiens	62-76
33066693-0	2020	Mechanism of the Affinity-Enhancing Effect of Isatin on Human Ferrochelatase and Adrenodoxin Reductase Complex Formation: Implication for Protein Interactome Regulation.	Isatin	46-52	ferredoxin reductase	Homo sapiens	81-102
33066693-3	2020	Recently, using Surface Plasmon Resonance (SPR) analysis, we have found that isatin in a concentration dependent manner increased interaction between two human mitochondrial proteins, ferrochelatase (FECH), and adrenodoxine reductase (ADR).	Isatin	77-83	ferrochelatase	Homo sapiens	184-198
33066693-3	2020	Recently, using Surface Plasmon Resonance (SPR) analysis, we have found that isatin in a concentration dependent manner increased interaction between two human mitochondrial proteins, ferrochelatase (FECH), and adrenodoxine reductase (ADR).	Isatin	77-83	ferrochelatase	Homo sapiens	200-204
33066693-3	2020	Recently, using Surface Plasmon Resonance (SPR) analysis, we have found that isatin in a concentration dependent manner increased interaction between two human mitochondrial proteins, ferrochelatase (FECH), and adrenodoxine reductase (ADR).	Isatin	77-83	aldo-keto reductase family 1 member B	Homo sapiens	211-233
33066693-3	2020	Recently, using Surface Plasmon Resonance (SPR) analysis, we have found that isatin in a concentration dependent manner increased interaction between two human mitochondrial proteins, ferrochelatase (FECH), and adrenodoxine reductase (ADR).	Isatin	77-83	aldo-keto reductase family 1 member B	Homo sapiens	235-238
33066693-4	2020	In this study, we have investigated the affinity-enhancing effect of isatin on the FECH/ADR interaction.	Isatin	69-75	ferrochelatase	Homo sapiens	83-87
33066693-4	2020	In this study, we have investigated the affinity-enhancing effect of isatin on the FECH/ADR interaction.	Isatin	69-75	aldo-keto reductase family 1 member B	Homo sapiens	88-91
33066693-6	2020	The affinity-enhancing effect of isatin on the FECH/ADR interaction was highly specific and was not reproduced by structural analogues of isatin.	Isatin	33-39	ferrochelatase	Homo sapiens	47-51
33066693-6	2020	The affinity-enhancing effect of isatin on the FECH/ADR interaction was highly specific and was not reproduced by structural analogues of isatin.	Isatin	33-39	aldo-keto reductase family 1 member B	Homo sapiens	52-55
33066693-7	2020	Bioinformatic analysis performed using three dimensional (3D) models of the interacting proteins and in silico molecular docking revealed the most probable mechanism involving FECH/isatin/ADR ternary complex formation.	Isatin	181-187	ferrochelatase	Homo sapiens	176-180
33066693-7	2020	Bioinformatic analysis performed using three dimensional (3D) models of the interacting proteins and in silico molecular docking revealed the most probable mechanism involving FECH/isatin/ADR ternary complex formation.	Isatin	181-187	aldo-keto reductase family 1 member B	Homo sapiens	188-191
33066693-8	2020	In this complex, isatin is targeted to the interface of interacting FECH and ADR monomers, forming hydrogen bonds with both FECH and ADR.	Isatin	17-23	ferrochelatase	Homo sapiens	68-72
33066693-8	2020	In this complex, isatin is targeted to the interface of interacting FECH and ADR monomers, forming hydrogen bonds with both FECH and ADR.	Isatin	17-23	aldo-keto reductase family 1 member B	Homo sapiens	77-80
33066693-8	2020	In this complex, isatin is targeted to the interface of interacting FECH and ADR monomers, forming hydrogen bonds with both FECH and ADR.	Isatin	17-23	ferrochelatase	Homo sapiens	124-128
33066693-8	2020	In this complex, isatin is targeted to the interface of interacting FECH and ADR monomers, forming hydrogen bonds with both FECH and ADR.	Isatin	17-23	aldo-keto reductase family 1 member B	Homo sapiens	133-136
32745759-0	2020	Novel scaffold hopping of potent benzothiazole and isatin analogues linked to 1,2,3-triazole fragment that mimic quinazoline epidermal growth factor receptor inhibitors: Synthesis, antitumor and mechanistic analyses.	Isatin	51-57	epidermal growth factor receptor	Homo sapiens	125-157
32775889-2	2020	Isatin moiety is a versatile group that is shared in many compounds targeting both c-Met and VEGFR2 kinases.	Isatin	0-6	MET proto-oncogene, receptor tyrosine kinase	Gallus gallus	83-88
32775889-2	2020	Isatin moiety is a versatile group that is shared in many compounds targeting both c-Met and VEGFR2 kinases.	Isatin	0-6	kinase insert domain receptor	Gallus gallus	93-99
32304702-1	2020	Isatin is an endogenous indole that inhibits monoamine oxidase (MAO).	Isatin	0-6	monoamine oxidase A	Rattus norvegicus	64-67
32148050-2	2020	A Yb(OTf)3-catalyzed reaction between alpha-alkynyl naphthalen-2-ols and isatins worked efficiently and offered a convergent and regioselective protocol to construct cyclic ketones via alkyne polyfunctionalization.	Isatin	73-80	POU class 5 homeobox 1	Homo sapiens	5-10
32380384-10	2020	Harmine, Clorgyline, Isatin, zonisamide and our title compound including are known with their competitive inhibitory activity on Human monoamine oxidase, commonly named MAO A and B.	Isatin	21-27	monoamine oxidase A	Homo sapiens	169-180
31882299-2	2020	Herein, in order to simplify the structure of two kinds of IDO1 inhibitors from marine alkaloid, Exiguamine A and Tsitsikammamines, we designed, synthesized a series of 1H-indole-4,7-dione derivatives and evaluated their inhibitory activity in IDO1 enzyme and in IFN-gamma stimulated Hela cells in vitro.	Isatin	169-188	indoleamine 2,3-dioxygenase 1	Homo sapiens	59-63
31793298-2	2019	Herein we depict an isatin-derived and 3,3"-di-substituted oxindole-appended epoxy-acrylate undergoing Cp2Ti(III)Cl-mediated reductive oxirane-ring opening with concomitant intramolecular 5-exo-trig radical cyclization leading to tetrahydrofuran based oxa-spirooxindole systems.	Isatin	20-26	ceruloplasmin	Homo sapiens	103-106
30652647-16	2020	Compound 6j was found to be too lipophilic due to their dihalo substitution on isatin nucleus, can be acts a lead molecule for further and useful for future development of new EGFR Inhibitors.	Isatin	79-85	epidermal growth factor receptor	Homo sapiens	176-180
31998813-0	2019	Novel Isatin-based activator of p53 transcriptional functions in tumor cells.	Isatin	6-12	tumor protein p53	Homo sapiens	32-35
31848442-0	2019	One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[123,125I]iodo-1,2,3-triazole derived Isatin SPECT Tracer.	Isatin	114-120	caspase 3	Homo sapiens	54-63
31848442-2	2019	Isatins are a class of compounds that target activated caspase-3 during apoptosis.	Isatin	0-7	caspase 3	Homo sapiens	55-64
31998813-4	2019	Here, we report novel data on p53 activating Isatin-based Cu(II) complex exhibiting cytotoxic properties towards HCT116 and MCF7 tumor cell lines, as confirmed by cell viability assay and flow cytometry analysis of apoptosis.	Isatin	45-51	tumor protein p53	Homo sapiens	30-33
30136587-0	2018	N, N"-Dioxide/Gd(OTf)3 Complex-Promoted Asymmetric Aldol Reaction of Silyl Ketene Imines with Isatins: Water Plays an Important Role.	Isatin	94-101	POU class 5 homeobox 1	Homo sapiens	17-22
31934071-0	2019	Isatin inhibits SH-SY5Y neuroblastoma cell invasion and metastasis through PTEN signaling.	Isatin	0-6	phosphatase and tensin homolog	Homo sapiens	75-79
31934071-11	2019	Isatin increased the expression level of H3K4m1 and phosphatase and tensin homolog (PTEN) and decreased the phosphorylation level of PTEN downstream proteins phosphoinositide 3-kinase, protein kinase B, mammalian target of rapamycin, focal adhesion kinase, and SHC.	Isatin	0-6	phosphatase and tensin homolog	Homo sapiens	84-88
31934071-11	2019	Isatin increased the expression level of H3K4m1 and phosphatase and tensin homolog (PTEN) and decreased the phosphorylation level of PTEN downstream proteins phosphoinositide 3-kinase, protein kinase B, mammalian target of rapamycin, focal adhesion kinase, and SHC.	Isatin	0-6	phosphatase and tensin homolog	Homo sapiens	133-137
31934071-11	2019	Isatin increased the expression level of H3K4m1 and phosphatase and tensin homolog (PTEN) and decreased the phosphorylation level of PTEN downstream proteins phosphoinositide 3-kinase, protein kinase B, mammalian target of rapamycin, focal adhesion kinase, and SHC.	Isatin	0-6	mechanistic target of rapamycin kinase	Homo sapiens	203-232
31934071-11	2019	Isatin increased the expression level of H3K4m1 and phosphatase and tensin homolog (PTEN) and decreased the phosphorylation level of PTEN downstream proteins phosphoinositide 3-kinase, protein kinase B, mammalian target of rapamycin, focal adhesion kinase, and SHC.	Isatin	0-6	SHC adaptor protein 1	Homo sapiens	261-264
31460047-0	2019	Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection-Deprotection Chemistry.	Isatin	25-32	keratin 10	Homo sapiens	124-128
30697888-2	2019	Reported here is an unprecedented auto-tandem cooperative catalysis (ATCC) for Morita-Baylis-Hillman carbonates from isatins and allylic carbonates using a simple Pd(PPh3 )4 precursor.	Isatin	117-124	protein phosphatase 4 catalytic subunit	Homo sapiens	166-170
30767538-0	2019	NHC-Catalyzed Aldol-Like Reactions of Allenoates with Isatins: Regiospecific Syntheses of gamma-Functionalized Allenoates.	Isatin	54-61	high mobility group nucleosomal binding domain 4	Homo sapiens	0-3
30767538-1	2019	An N-heterocyclic carbene (NHC) catalyzed gamma-specific aldol-like reaction between allenoates and isatins has been achieved under mild conditions, giving trisubstituted allene derivatives bearing isatin moiety in moderate to good yields with high diastereoselectivity and excellent atom efficiency.	Isatin	100-107	high mobility group nucleosomal binding domain 4	Homo sapiens	27-30
30767538-1	2019	An N-heterocyclic carbene (NHC) catalyzed gamma-specific aldol-like reaction between allenoates and isatins has been achieved under mild conditions, giving trisubstituted allene derivatives bearing isatin moiety in moderate to good yields with high diastereoselectivity and excellent atom efficiency.	Isatin	100-106	high mobility group nucleosomal binding domain 4	Homo sapiens	27-30
30768094-4	2019	Thus, indole derivatives presented a ligand-to-ligand-charge-transfer transition (LLCT) from the indole to the PPh3 fragment, whereas for the isatin derivatives an intraligand-charge-transfer transition (ILCT) within the isatin fragment is proposed.	Isatin	142-148	caveolin 1	Homo sapiens	111-115
31079165-0	2019	N-Pyrazoloyl and N-thiopheneacetyl hydrazone of isatin exhibited potent anti-inflammatory and anti-nociceptive properties through suppression of NF-kappaB, MAPK and oxidative stress signaling in animal models of inflammation.	Isatin	48-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-154
30792039-1	2019	Herein we report our efforts of developing reversible selective hMAO-B inhibitors based on isatin, a fragment in an X-ray crystal structure.	Isatin	91-97	monoamine oxidase B	Homo sapiens	64-70
30792039-4	2019	However, the endeavors to modify the polar 3-one group of isatin, that is in a hydrophobic environment in the binding site of hMAO-B, to small nonpolar hydrophobic groups did not bring about improved hMAO-B inhibitors, which may challenge our understanding of molecular interactions and molecular recognition in biological systems.	Isatin	58-64	monoamine oxidase B	Homo sapiens	126-132
30445264-5	2019	Molecular docking of the designed hybrids in CA IX active site unveiled, as planned, the ability of N-alkylated and N-benzylated isatin moieties to accommodate in a wide hydrophobic pocket formed by T73, P75, P76, L91, L123 and A128, establishing strong van der Waals interactions.	Isatin	129-135	carbonic anhydrase 9	Homo sapiens	45-50
30445264-5	2019	Molecular docking of the designed hybrids in CA IX active site unveiled, as planned, the ability of N-alkylated and N-benzylated isatin moieties to accommodate in a wide hydrophobic pocket formed by T73, P75, P76, L91, L123 and A128, establishing strong van der Waals interactions.	Isatin	129-135	PC4 and SFRS1 interacting protein 1	Homo sapiens	204-207
30445264-5	2019	Molecular docking of the designed hybrids in CA IX active site unveiled, as planned, the ability of N-alkylated and N-benzylated isatin moieties to accommodate in a wide hydrophobic pocket formed by T73, P75, P76, L91, L123 and A128, establishing strong van der Waals interactions.	Isatin	129-135	phospholipase B domain containing 2	Homo sapiens	209-212
30257379-10	2018	To the best of our knowledge this is the first report on the FAAH inhibitory properties of isatin-based analogs, revealing that both indoline skeleton and heteroaryl substitution at C-3 can modulate the activity of FAAH enzyme.	Isatin	91-97	fatty acid amide hydrolase	Homo sapiens	61-65
30257379-10	2018	To the best of our knowledge this is the first report on the FAAH inhibitory properties of isatin-based analogs, revealing that both indoline skeleton and heteroaryl substitution at C-3 can modulate the activity of FAAH enzyme.	Isatin	91-97	fatty acid amide hydrolase	Homo sapiens	215-219
29671340-4	2018	The results showed that indirubin and isatin, individually or combined, significantly inhibited weight loss, lowered disease activity index (DAI), ameliorated pathological changes, decreased the levels of pro-inflammatory mediators and myeloperoxidase (MPO) activity, increased the expression of anti-inflammatory cytokines and Foxp3, suppressed CD4+ T cell infiltration, and inhibited oxidative stress and epithelial cell apoptosis.	Isatin	38-44	myeloperoxidase	Mus musculus	236-251
29671340-4	2018	The results showed that indirubin and isatin, individually or combined, significantly inhibited weight loss, lowered disease activity index (DAI), ameliorated pathological changes, decreased the levels of pro-inflammatory mediators and myeloperoxidase (MPO) activity, increased the expression of anti-inflammatory cytokines and Foxp3, suppressed CD4+ T cell infiltration, and inhibited oxidative stress and epithelial cell apoptosis.	Isatin	38-44	myeloperoxidase	Mus musculus	253-256
29671340-4	2018	The results showed that indirubin and isatin, individually or combined, significantly inhibited weight loss, lowered disease activity index (DAI), ameliorated pathological changes, decreased the levels of pro-inflammatory mediators and myeloperoxidase (MPO) activity, increased the expression of anti-inflammatory cytokines and Foxp3, suppressed CD4+ T cell infiltration, and inhibited oxidative stress and epithelial cell apoptosis.	Isatin	38-44	forkhead box P3	Mus musculus	328-333
30378558-0	2018	[The effect of the neuroprotector isatin on complex formation of beta-amyloid peptide fragments with some intracellular proteins].	Isatin	34-40	amyloid beta precursor protein	Homo sapiens	65-85
29803079-0	2018	Synthesis, SAR elucidations and molecular docking study of newly designed isatin based oxadiazole analogs as potent inhibitors of thymidine phosphorylase.	Isatin	74-80	sarcosine dehydrogenase	Homo sapiens	11-14
30378558-4	2018	The aim of this study was to investigate the effect of the neuroprotector isatin (100 mM) on interaction of known Abeta-binding proteins, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase, with Abeta1-42 and its fragments (Abeta1-28, Abeta12-28, Abeta25-35).	Isatin	74-80	amyloid beta precursor protein	Homo sapiens	114-119
30378558-4	2018	The aim of this study was to investigate the effect of the neuroprotector isatin (100 mM) on interaction of known Abeta-binding proteins, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase, with Abeta1-42 and its fragments (Abeta1-28, Abeta12-28, Abeta25-35).	Isatin	74-80	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	138-178
30378558-4	2018	The aim of this study was to investigate the effect of the neuroprotector isatin (100 mM) on interaction of known Abeta-binding proteins, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase, with Abeta1-42 and its fragments (Abeta1-28, Abeta12-28, Abeta25-35).	Isatin	74-80	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	180-185
30378558-7	2018	The presence of 100 mM isatin caused a significant (more than fivefold) increase in the Kd values for GAPDH complexes with all Abeta peptides except Abeta1-28.	Isatin	23-29	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	102-107
30378558-7	2018	The presence of 100 mM isatin caused a significant (more than fivefold) increase in the Kd values for GAPDH complexes with all Abeta peptides except Abeta1-28.	Isatin	23-29	amyloid beta precursor protein	Homo sapiens	127-132
30378558-9	2018	It should be noted that in the presence of isatin the Kd values for GAPDH and pyruvate kinase complexes with all Abeta studied were in a narrower concentration range (10-7 M - 10-6 M) than in the absence of this neuroprotector (10-8 M - 10-6 M).	Isatin	43-49	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	68-73
30378558-9	2018	It should be noted that in the presence of isatin the Kd values for GAPDH and pyruvate kinase complexes with all Abeta studied were in a narrower concentration range (10-7 M - 10-6 M) than in the absence of this neuroprotector (10-8 M - 10-6 M).	Isatin	43-49	amyloid beta precursor protein	Homo sapiens	113-118
29870246-1	2018	Herein, we report a chemoselective P(NMe2)3-mediated reductive epoxidation of alpha-dicarbonyl compounds such as isatins, alpha-keto esters, and alpha-diketones with aldehydes and ketones, leading to an efficient synthesis of a wide range of highly functionalized unsymmetrical epoxides in moderate to excellent yields and diastereoselectivities.	Isatin	113-120	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	37-41
29472125-0	2018	Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors.	Isatin	13-19	D-amino acid oxidase	Mus musculus	55-75
29648434-3	2018	Theoretical simulation and LDI detection of indigo and isatin molecules in negative ion mode revealed that the electric field can be enhanced on the tip end of SiNWs, thereby promoting the energy and electron transfer to the analytes adsorbed on the tip of SiNWs.	Isatin	55-61	TOR signaling pathway regulator	Homo sapiens	149-152
29648434-3	2018	Theoretical simulation and LDI detection of indigo and isatin molecules in negative ion mode revealed that the electric field can be enhanced on the tip end of SiNWs, thereby promoting the energy and electron transfer to the analytes adsorbed on the tip of SiNWs.	Isatin	55-61	TOR signaling pathway regulator	Homo sapiens	250-253
29472125-0	2018	Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors.	Isatin	13-19	D-amino acid oxidase	Mus musculus	77-81
29472125-2	2018	Inhibitors of DAAO were sought testing [6+5] type heterocycles and identified isatin derivatives as micromolar DAAO inhibitors.	Isatin	78-84	D-amino acid oxidase	Mus musculus	14-18
29472125-2	2018	Inhibitors of DAAO were sought testing [6+5] type heterocycles and identified isatin derivatives as micromolar DAAO inhibitors.	Isatin	78-84	D-amino acid oxidase	Mus musculus	111-115
29472125-3	2018	A pharmacophore and structure-activity relationship analysis of isatins and reported DAAO inhibitors led us to investigate 1H-indazol-3-ol derivatives and nanomolar inhibitors were identified.	Isatin	64-71	D-amino acid oxidase	Mus musculus	85-89
29355329-2	2018	The very remote zeta,eta-alkenes perform as effective HOMO-raised dienophiles in inverse-electron-demand oxa-Diels-Alder cycloadditions with isatin-derived oxadiene substrates, delivering multifunctional spirocyclic oxindoles incorporating a dihydropyran skeleton in moderate to high yields with good to excellent enantio- and diastereoselectivity.	Isatin	141-147	endothelin receptor type A	Homo sapiens	17-20
29336068-10	2018	Physiological concentrations of isatin in vitro inhibit monoamine oxidase B and natriuretic peptide receptor guanylate cyclase, higher (neuroprotective) concentrations (50-400 muM) cause apoptosis of various (including malignant tumor) cell lines and influence expression of certain apoptosis-related genes.	Isatin	32-38	monoamine oxidase B	Rattus norvegicus	56-75
29298039-10	2018	Using the MEA sensor, the limit of detection (LOD, (3sigma)/m) for isatin was found to be 0.04 muM; an increase to 0.22 muM was observed with the MAC sensor.	Isatin	67-73	latexin	Homo sapiens	95-98
28738722-0	2017	Effects of indirubin and isatin on cell viability, mutagenicity, genotoxicity and BAX/ERCC1 gene expression.	Isatin	25-31	BCL2 associated X, apoptosis regulator	Homo sapiens	82-85
30109812-0	2018	Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis.	Isatin	6-12	tumor protein p53	Homo sapiens	40-43
30109812-0	2018	Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis.	Isatin	6-12	MDM2 proto-oncogene	Homo sapiens	66-70
29460836-4	2018	In this work, an attempt has been undertaken to register a direct interaction of isatin with a set of different proteins related to the functioning of cytochrome P450-dependent monooxygenase: five isoforms of cytochromes P450, two isoforms of cytochrome b5, cytochrome P450 reductase, adrenodoxin, adrenodoxin reductase and ferrochelatase.	Isatin	81-87	ferredoxin reductase	Homo sapiens	298-319
29460836-4	2018	In this work, an attempt has been undertaken to register a direct interaction of isatin with a set of different proteins related to the functioning of cytochrome P450-dependent monooxygenase: five isoforms of cytochromes P450, two isoforms of cytochrome b5, cytochrome P450 reductase, adrenodoxin, adrenodoxin reductase and ferrochelatase.	Isatin	81-87	ferrochelatase	Homo sapiens	324-338
29151266-5	2018	A more detailed biochemical and catalytic characterization shows that DHRS4_CAEEL shares some properties with human DHRS4 such as relatively low substrate affinities with aliphatic alpha-diketones and a preference for aromatic dicarbonyls such as isatin, with a 30-fold lower Km value compared with the human enzyme.	Isatin	247-253	Dehydrogenase/reductase SDR family member 4	Caenorhabditis elegans	70-75
29151266-5	2018	A more detailed biochemical and catalytic characterization shows that DHRS4_CAEEL shares some properties with human DHRS4 such as relatively low substrate affinities with aliphatic alpha-diketones and a preference for aromatic dicarbonyls such as isatin, with a 30-fold lower Km value compared with the human enzyme.	Isatin	247-253	dehydrogenase/reductase 4	Homo sapiens	116-121
28905435-0	2017	Isatin-induced increase in the affinity of human ferrochelatase and adrenodoxin reductase interaction.	Isatin	0-6	ferrochelatase	Homo sapiens	49-63
28905435-0	2017	Isatin-induced increase in the affinity of human ferrochelatase and adrenodoxin reductase interaction.	Isatin	0-6	ferredoxin reductase	Homo sapiens	68-89
28905435-4	2017	In this surface plasmon resonance-based biosensor study we have found that physiologically relevant concentrations of isatin (25-100 muM) increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH-dependent adrenodoxin reductase (ADR).	Isatin	118-124	ferrochelatase	Homo sapiens	198-212
28905435-4	2017	In this surface plasmon resonance-based biosensor study we have found that physiologically relevant concentrations of isatin (25-100 muM) increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH-dependent adrenodoxin reductase (ADR).	Isatin	118-124	ferrochelatase	Homo sapiens	214-218
28905435-4	2017	In this surface plasmon resonance-based biosensor study we have found that physiologically relevant concentrations of isatin (25-100 muM) increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH-dependent adrenodoxin reductase (ADR).	Isatin	118-124	ferredoxin reductase	Homo sapiens	240-261
28905435-4	2017	In this surface plasmon resonance-based biosensor study we have found that physiologically relevant concentrations of isatin (25-100 muM) increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH-dependent adrenodoxin reductase (ADR).	Isatin	118-124	aldo-keto reductase family 1 member B	Homo sapiens	263-266
28905435-6	2017	It is especially important that the interaction of isatin with each individual protein (FECH, ADR) was basically negligible and therefore could not contribute to the observed effect.	Isatin	51-57	ferrochelatase	Homo sapiens	88-92
29340222-6	2017	Importantly, the TBXAS1 CYP2E1 complex formation increases fivefold in the presence of isatin (indole-2,3-dione, a low-molecular nonpeptide endogenous bioregulator, a product of CYP2E1).	Isatin	87-93	thromboxane A synthase 1	Homo sapiens	17-23
29058439-0	2017	Rh(II)-Catalyzed Denitrogenative Reaction of N-Sulfonyl-1,2,3-triazoles with Isatins for the Construction of Indigoids.	Isatin	77-84	Rh blood group D antigen	Homo sapiens	0-6
29058439-1	2017	A convenient, Rh(II)-catalyzed, denitrogenative reaction of N-sulfonyl-1,2,3-triazoles and isatins to access (E)-2-(1-amino-2-oxo-2-phenylethylidene)indolin-3-ones, the core structure of indigo dyes, was achieved under operationally simple conditions with high levels of diastereoselectivity.	Isatin	91-98	Rh blood group D antigen	Homo sapiens	14-19
29082414-1	2017	A highly efficient TMSOTf-mediated asymmetric acetate-Mannich reaction of isatin derived tert-butylsulfinyl ketimines and S-phenyl thioacetate was developed to afford the direct synthesis of indole-based beta3,3-amino acid thioester with excellent selectivity (dr > 98 : 2).	Isatin	74-80	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	204-211
28956607-0	2017	P(NMe2)3-Mediated Reductive (1 + 4) Annulation Reaction of Isatins with Nitroalkenes: An Access to Spirooxindolyl Isoxazoline N-Oxides and Their Corresponding Isoxazolines.	Isatin	59-66	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	2-6
28956607-2	2017	This reaction presumably proceeds through a Michael addition-intramolecular substitution sequence via active in situ generated Kukhtin-Ramirez zwitterions from isatins and P(NMe2)3.	Isatin	160-167	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	174-178
29340222-6	2017	Importantly, the TBXAS1 CYP2E1 complex formation increases fivefold in the presence of isatin (indole-2,3-dione, a low-molecular nonpeptide endogenous bioregulator, a product of CYP2E1).	Isatin	87-93	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	24-30
29340222-6	2017	Importantly, the TBXAS1 CYP2E1 complex formation increases fivefold in the presence of isatin (indole-2,3-dione, a low-molecular nonpeptide endogenous bioregulator, a product of CYP2E1).	Isatin	87-93	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	178-184
29340222-6	2017	Importantly, the TBXAS1 CYP2E1 complex formation increases fivefold in the presence of isatin (indole-2,3-dione, a low-molecular nonpeptide endogenous bioregulator, a product of CYP2E1).	Isatin	95-111	thromboxane A synthase 1	Homo sapiens	17-23
29340222-6	2017	Importantly, the TBXAS1 CYP2E1 complex formation increases fivefold in the presence of isatin (indole-2,3-dione, a low-molecular nonpeptide endogenous bioregulator, a product of CYP2E1).	Isatin	95-111	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	24-30
29340222-6	2017	Importantly, the TBXAS1 CYP2E1 complex formation increases fivefold in the presence of isatin (indole-2,3-dione, a low-molecular nonpeptide endogenous bioregulator, a product of CYP2E1).	Isatin	95-111	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	178-184
28604855-1	2017	A novel P(NMe2)3-mediated formal carbon-halogen bond insertion of isatins into allylic and benzylic bromides/chlorides has been realized, leading to a facile synthesis of 3-halo 3,3"-disubstituted oxindoles.	Isatin	66-73	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	10-14
28450226-1	2017	Human carbonyl reductase 1 (CBR1), a member of the short-chain dehydrogenase/reductase (SDR) superfamily, reduces a variety of carbonyl compounds including endogenous isatin, prostaglandin E2 and 4-oxo-2-nonenal.	Isatin	167-173	carbonyl reductase 1	Homo sapiens	6-26
28450226-1	2017	Human carbonyl reductase 1 (CBR1), a member of the short-chain dehydrogenase/reductase (SDR) superfamily, reduces a variety of carbonyl compounds including endogenous isatin, prostaglandin E2 and 4-oxo-2-nonenal.	Isatin	167-173	carbonyl reductase 1	Homo sapiens	28-32
28816452-0	2017	Active sp3 C-H Bond Oxidation Initiated sp3-sp2 Consecutive C-H Functionalization of N-Arylglycine Amides: Construction of Isatins.	Isatin	123-130	Sp3 transcription factor	Homo sapiens	7-10
28816452-0	2017	Active sp3 C-H Bond Oxidation Initiated sp3-sp2 Consecutive C-H Functionalization of N-Arylglycine Amides: Construction of Isatins.	Isatin	123-130	Sp3 transcription factor	Homo sapiens	40-43
28816452-0	2017	Active sp3 C-H Bond Oxidation Initiated sp3-sp2 Consecutive C-H Functionalization of N-Arylglycine Amides: Construction of Isatins.	Isatin	123-130	Sp2 transcription factor	Homo sapiens	44-47
28816452-1	2017	In the presence of catalytic triarylamine radical cation, an sp3-sp2 consecutive C-H functionalization of N-arylglycine amides was achieved, providing a series of isatin derivatives in high yields.	Isatin	163-169	Sp3 transcription factor	Homo sapiens	61-64
28816452-1	2017	In the presence of catalytic triarylamine radical cation, an sp3-sp2 consecutive C-H functionalization of N-arylglycine amides was achieved, providing a series of isatin derivatives in high yields.	Isatin	163-169	Sp2 transcription factor	Homo sapiens	65-68
28379899-0	2017	Isatin inhibits SH-SY5Y neuroblastoma cell invasion and metastasis through MAO/HIF-1alpha/CXCR4 signaling.	Isatin	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
28379899-0	2017	Isatin inhibits SH-SY5Y neuroblastoma cell invasion and metastasis through MAO/HIF-1alpha/CXCR4 signaling.	Isatin	0-6	C-X-C motif chemokine receptor 4	Homo sapiens	90-95
28379899-4	2017	Moreover, isatin inhibited the expression level of monoamine oxidase A as well as that of its downstream protein hypoxia-inducible factor 1alpha.	Isatin	10-16	monoamine oxidase A	Homo sapiens	51-70
28379899-4	2017	Moreover, isatin inhibited the expression level of monoamine oxidase A as well as that of its downstream protein hypoxia-inducible factor 1alpha.	Isatin	10-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-144
28775867-7	2017	The title compound and the selected biological target VEGFR-2 show the N-H O(GLU94), (CYS96)N-H O(isatine) and (PHE95)N-H O(isatine) inter-molecular inter-actions, which suggests a solid theoretical structure-activity relationship.	Isatin	98-105	kinase insert domain receptor	Homo sapiens	54-61
28775867-7	2017	The title compound and the selected biological target VEGFR-2 show the N-H O(GLU94), (CYS96)N-H O(isatine) and (PHE95)N-H O(isatine) inter-molecular inter-actions, which suggests a solid theoretical structure-activity relationship.	Isatin	124-131	kinase insert domain receptor	Homo sapiens	54-61
28506067-0	2017	PPh3 Mediated Reductive Annulation Reaction between Isatins and Electron Deficient Dienes to Construct Spirooxindole Compounds.	Isatin	52-59	caveolin 1	Homo sapiens	0-4
28506067-1	2017	A PPh3 mediated reductive annulation reaction between isatins and 4,4-dicyano-2-methylenebut-3-enoates was developed.	Isatin	54-61	caveolin 1	Homo sapiens	2-6