PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 523344-1 1979 Qualitative and semiquantitative histochemical investigations of acetylcholinesterase after a single or repeated administration of isatin, 160 mg/kg ip once or daily for 8 consecutive days have revealed a significant decrease of the histochemical reaction for acetylcholinesterase in chronically treated rats. Isatin 131-137 acetylcholinesterase Rattus norvegicus 65-85 3392550-4 1988 Isatin is a potent inhibitor of MAO, particularly of MAO B (IC50, 3 microM), and also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 microM). Isatin 0-6 monoamine oxidase B Homo sapiens 53-58 523344-1 1979 Qualitative and semiquantitative histochemical investigations of acetylcholinesterase after a single or repeated administration of isatin, 160 mg/kg ip once or daily for 8 consecutive days have revealed a significant decrease of the histochemical reaction for acetylcholinesterase in chronically treated rats. Isatin 131-137 acetylcholinesterase Rattus norvegicus 260-280 33367935-3 2021 Mechanistically, isatin inhibited lysine-specific histone demethylase (LSD)1 and reversed the blockade on p53, thereby activating the apoptotic pathway. Isatin 17-23 lysine demethylase 1A Homo sapiens 50-76 34022091-0 2021 Participation of glutamatergic and nitrergic systems in the striatal dopamine release induced by isatin, a MAO inhibitor. Isatin 97-103 monoamine oxidase A Rattus norvegicus 107-110 33540058-4 2021 For this, (3Z)-5-Chloro-3-(hydroxyimino)indolin-2-one (Cl-HIN), a compound that has properties of isatin and oxime in its structure, have shown reactivating properties in the activity of AChE that have been added to antidepressant-like effects in rats exposed to malathion in acute protocol. Isatin 98-104 acetylcholinesterase Rattus norvegicus 187-191 33506699-1 2021 Aim: Keeping in view the side effects associated with clinically used alpha-glucosidase inhibitors, novel thiazolidinedione-isatin hybrids were synthesized and evaluated by in vitro, in vivo and in silico procedures. Isatin 124-130 sucrase-isomaltase Homo sapiens 70-87 33645522-0 2021 [Changes in the mitochondrial subproteome of mouse brain Rpn13-binding proteins induced by the neurotoxin MPTP and the neuroprotector isatin]. Isatin 134-140 adhesion regulating molecule 1 Mus musculus 57-62 33645522-5 2021 In this study we have investigated the effect of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and the neuroprotector isatin on the mitochondrial subproteome of Rpn13-binding proteins of the mouse brain. Isatin 139-145 adhesion regulating molecule 1 Mus musculus 182-187 33645522-7 2021 At the same time, the injection of MPTP, isatin, or their combination (isatin + MPTP) had a significant impact on the total number and the composition of Rpn13-binding proteins. Isatin 41-47 adhesion regulating molecule 1 Mus musculus 154-159 33645522-7 2021 At the same time, the injection of MPTP, isatin, or their combination (isatin + MPTP) had a significant impact on the total number and the composition of Rpn13-binding proteins. Isatin 71-77 adhesion regulating molecule 1 Mus musculus 154-159 33645522-8 2021 The injection of MPTP decreased the total number of Rpn13-binding proteins in comparison with control, and the injection of isatin prior to MPTP or without MPTP caused an essential increase in the number of Rpn13-binding proteins, mainly of the functional group of proteins participating in the protein metabolism regulation, gene expression, and differentiation. Isatin 124-130 adhesion regulating molecule 1 Mus musculus 52-57 33645522-8 2021 The injection of MPTP decreased the total number of Rpn13-binding proteins in comparison with control, and the injection of isatin prior to MPTP or without MPTP caused an essential increase in the number of Rpn13-binding proteins, mainly of the functional group of proteins participating in the protein metabolism regulation, gene expression, and differentiation. Isatin 124-130 adhesion regulating molecule 1 Mus musculus 207-212 33684714-3 2021 In this regard, the present work aims at developing a new set of small molecules featuring the privileged isatin scaffold conjugated with a thiazolo[3,2-a]benzimidazole (TBI) motif through a cleavable hydrazide linker (7a-e and 10a-i) as potential anticancer CDK2 inhibitors. Isatin 106-112 cyclin dependent kinase 2 Homo sapiens 259-263 33367935-3 2021 Mechanistically, isatin inhibited lysine-specific histone demethylase (LSD)1 and reversed the blockade on p53, thereby activating the apoptotic pathway. Isatin 17-23 tumor protein p53 Homo sapiens 106-109 33367935-4 2021 The inhibitory effect of isatin on LSD1 may be mediated via direct binding and molecular docking or indirectly through the TGFbeta/ERK/NF-kappaB signaling pathway. Isatin 25-31 lysine demethylase 1A Homo sapiens 35-39 33367935-4 2021 The inhibitory effect of isatin on LSD1 may be mediated via direct binding and molecular docking or indirectly through the TGFbeta/ERK/NF-kappaB signaling pathway. Isatin 25-31 mitogen-activated protein kinase 1 Homo sapiens 131-134 33367935-4 2021 The inhibitory effect of isatin on LSD1 may be mediated via direct binding and molecular docking or indirectly through the TGFbeta/ERK/NF-kappaB signaling pathway. Isatin 25-31 nuclear factor kappa B subunit 1 Homo sapiens 135-144 32745759-0 2020 Novel scaffold hopping of potent benzothiazole and isatin analogues linked to 1,2,3-triazole fragment that mimic quinazoline epidermal growth factor receptor inhibitors: Synthesis, antitumor and mechanistic analyses. Isatin 51-57 epidermal growth factor receptor Homo sapiens 125-157 33066693-0 2020 Mechanism of the Affinity-Enhancing Effect of Isatin on Human Ferrochelatase and Adrenodoxin Reductase Complex Formation: Implication for Protein Interactome Regulation. Isatin 46-52 ferrochelatase Homo sapiens 62-76 33066693-0 2020 Mechanism of the Affinity-Enhancing Effect of Isatin on Human Ferrochelatase and Adrenodoxin Reductase Complex Formation: Implication for Protein Interactome Regulation. Isatin 46-52 ferredoxin reductase Homo sapiens 81-102 33066693-3 2020 Recently, using Surface Plasmon Resonance (SPR) analysis, we have found that isatin in a concentration dependent manner increased interaction between two human mitochondrial proteins, ferrochelatase (FECH), and adrenodoxine reductase (ADR). Isatin 77-83 ferrochelatase Homo sapiens 184-198 33066693-3 2020 Recently, using Surface Plasmon Resonance (SPR) analysis, we have found that isatin in a concentration dependent manner increased interaction between two human mitochondrial proteins, ferrochelatase (FECH), and adrenodoxine reductase (ADR). Isatin 77-83 ferrochelatase Homo sapiens 200-204 33066693-3 2020 Recently, using Surface Plasmon Resonance (SPR) analysis, we have found that isatin in a concentration dependent manner increased interaction between two human mitochondrial proteins, ferrochelatase (FECH), and adrenodoxine reductase (ADR). Isatin 77-83 aldo-keto reductase family 1 member B Homo sapiens 211-233 33066693-3 2020 Recently, using Surface Plasmon Resonance (SPR) analysis, we have found that isatin in a concentration dependent manner increased interaction between two human mitochondrial proteins, ferrochelatase (FECH), and adrenodoxine reductase (ADR). Isatin 77-83 aldo-keto reductase family 1 member B Homo sapiens 235-238 33066693-4 2020 In this study, we have investigated the affinity-enhancing effect of isatin on the FECH/ADR interaction. Isatin 69-75 ferrochelatase Homo sapiens 83-87 33066693-4 2020 In this study, we have investigated the affinity-enhancing effect of isatin on the FECH/ADR interaction. Isatin 69-75 aldo-keto reductase family 1 member B Homo sapiens 88-91 33066693-6 2020 The affinity-enhancing effect of isatin on the FECH/ADR interaction was highly specific and was not reproduced by structural analogues of isatin. Isatin 33-39 ferrochelatase Homo sapiens 47-51 33066693-6 2020 The affinity-enhancing effect of isatin on the FECH/ADR interaction was highly specific and was not reproduced by structural analogues of isatin. Isatin 33-39 aldo-keto reductase family 1 member B Homo sapiens 52-55 33066693-7 2020 Bioinformatic analysis performed using three dimensional (3D) models of the interacting proteins and in silico molecular docking revealed the most probable mechanism involving FECH/isatin/ADR ternary complex formation. Isatin 181-187 ferrochelatase Homo sapiens 176-180 33066693-7 2020 Bioinformatic analysis performed using three dimensional (3D) models of the interacting proteins and in silico molecular docking revealed the most probable mechanism involving FECH/isatin/ADR ternary complex formation. Isatin 181-187 aldo-keto reductase family 1 member B Homo sapiens 188-191 33066693-8 2020 In this complex, isatin is targeted to the interface of interacting FECH and ADR monomers, forming hydrogen bonds with both FECH and ADR. Isatin 17-23 ferrochelatase Homo sapiens 68-72 33066693-8 2020 In this complex, isatin is targeted to the interface of interacting FECH and ADR monomers, forming hydrogen bonds with both FECH and ADR. Isatin 17-23 aldo-keto reductase family 1 member B Homo sapiens 77-80 33066693-8 2020 In this complex, isatin is targeted to the interface of interacting FECH and ADR monomers, forming hydrogen bonds with both FECH and ADR. Isatin 17-23 ferrochelatase Homo sapiens 124-128 33066693-8 2020 In this complex, isatin is targeted to the interface of interacting FECH and ADR monomers, forming hydrogen bonds with both FECH and ADR. Isatin 17-23 aldo-keto reductase family 1 member B Homo sapiens 133-136 33308120-10 2022 RESULTS: Three compounds 12d, 12e and 12h with propionyl and butyroyl linker between amine and isatin Schiff base scaffold have shown potent acetyl and butyryl cholinesterase inhibitory activity. Isatin 95-101 butyrylcholinesterase Homo sapiens 160-174 33200681-0 2022 Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (mpro): a molecular docking, molecular dynamics and structure-activity relationship studies. Isatin 47-53 NEWENTRY Severe acute respiratory syndrome-related coronavirus 100-104 33200681-5 2022 Molecular docking analysis against Mpro protein were performed finding isatin linked with a oxidiazoles (A2 and A4) derivatives to have the best docking scores of -11.22 kcal/mol and -11.15 kcal/mol respectively. Isatin 71-77 NEWENTRY Severe acute respiratory syndrome-related coronavirus 35-39 30652647-16 2020 Compound 6j was found to be too lipophilic due to their dihalo substitution on isatin nucleus, can be acts a lead molecule for further and useful for future development of new EGFR Inhibitors. Isatin 79-85 epidermal growth factor receptor Homo sapiens 176-180 32304702-1 2020 Isatin is an endogenous indole that inhibits monoamine oxidase (MAO). Isatin 0-6 monoamine oxidase A Rattus norvegicus 45-62 32304702-1 2020 Isatin is an endogenous indole that inhibits monoamine oxidase (MAO). Isatin 0-6 monoamine oxidase A Rattus norvegicus 64-67 32380384-10 2020 Harmine, Clorgyline, Isatin, zonisamide and our title compound including are known with their competitive inhibitory activity on Human monoamine oxidase, commonly named MAO A and B. Isatin 21-27 monoamine oxidase A Homo sapiens 169-180 32148050-2 2020 A Yb(OTf)3-catalyzed reaction between alpha-alkynyl naphthalen-2-ols and isatins worked efficiently and offered a convergent and regioselective protocol to construct cyclic ketones via alkyne polyfunctionalization. Isatin 73-80 POU class 5 homeobox 1 Homo sapiens 5-10 31882299-2 2020 Herein, in order to simplify the structure of two kinds of IDO1 inhibitors from marine alkaloid, Exiguamine A and Tsitsikammamines, we designed, synthesized a series of 1H-indole-4,7-dione derivatives and evaluated their inhibitory activity in IDO1 enzyme and in IFN-gamma stimulated Hela cells in vitro. Isatin 169-188 indoleamine 2,3-dioxygenase 1 Homo sapiens 59-63 32775889-2 2020 Isatin moiety is a versatile group that is shared in many compounds targeting both c-Met and VEGFR2 kinases. Isatin 0-6 MET proto-oncogene, receptor tyrosine kinase Gallus gallus 83-88 32775889-2 2020 Isatin moiety is a versatile group that is shared in many compounds targeting both c-Met and VEGFR2 kinases. Isatin 0-6 kinase insert domain receptor Gallus gallus 93-99 31793298-2 2019 Herein we depict an isatin-derived and 3,3"-di-substituted oxindole-appended epoxy-acrylate undergoing Cp2Ti(III)Cl-mediated reductive oxirane-ring opening with concomitant intramolecular 5-exo-trig radical cyclization leading to tetrahydrofuran based oxa-spirooxindole systems. Isatin 20-26 ceruloplasmin Homo sapiens 103-106 31998813-0 2019 Novel Isatin-based activator of p53 transcriptional functions in tumor cells. Isatin 6-12 tumor protein p53 Homo sapiens 32-35 31848442-0 2019 One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[123,125I]iodo-1,2,3-triazole derived Isatin SPECT Tracer. Isatin 114-120 caspase 3 Homo sapiens 54-63 31848442-2 2019 Isatins are a class of compounds that target activated caspase-3 during apoptosis. Isatin 0-7 caspase 3 Homo sapiens 55-64 31998813-4 2019 Here, we report novel data on p53 activating Isatin-based Cu(II) complex exhibiting cytotoxic properties towards HCT116 and MCF7 tumor cell lines, as confirmed by cell viability assay and flow cytometry analysis of apoptosis. Isatin 45-51 tumor protein p53 Homo sapiens 30-33 31460047-0 2019 Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection-Deprotection Chemistry. Isatin 25-32 keratin 10 Homo sapiens 124-128 31079165-0 2019 N-Pyrazoloyl and N-thiopheneacetyl hydrazone of isatin exhibited potent anti-inflammatory and anti-nociceptive properties through suppression of NF-kappaB, MAPK and oxidative stress signaling in animal models of inflammation. Isatin 48-54 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 145-154 31934071-0 2019 Isatin inhibits SH-SY5Y neuroblastoma cell invasion and metastasis through PTEN signaling. Isatin 0-6 phosphatase and tensin homolog Homo sapiens 75-79 31934071-11 2019 Isatin increased the expression level of H3K4m1 and phosphatase and tensin homolog (PTEN) and decreased the phosphorylation level of PTEN downstream proteins phosphoinositide 3-kinase, protein kinase B, mammalian target of rapamycin, focal adhesion kinase, and SHC. Isatin 0-6 phosphatase and tensin homolog Homo sapiens 84-88 31934071-11 2019 Isatin increased the expression level of H3K4m1 and phosphatase and tensin homolog (PTEN) and decreased the phosphorylation level of PTEN downstream proteins phosphoinositide 3-kinase, protein kinase B, mammalian target of rapamycin, focal adhesion kinase, and SHC. Isatin 0-6 phosphatase and tensin homolog Homo sapiens 133-137 31934071-11 2019 Isatin increased the expression level of H3K4m1 and phosphatase and tensin homolog (PTEN) and decreased the phosphorylation level of PTEN downstream proteins phosphoinositide 3-kinase, protein kinase B, mammalian target of rapamycin, focal adhesion kinase, and SHC. Isatin 0-6 mechanistic target of rapamycin kinase Homo sapiens 203-232 31934071-11 2019 Isatin increased the expression level of H3K4m1 and phosphatase and tensin homolog (PTEN) and decreased the phosphorylation level of PTEN downstream proteins phosphoinositide 3-kinase, protein kinase B, mammalian target of rapamycin, focal adhesion kinase, and SHC. Isatin 0-6 SHC adaptor protein 1 Homo sapiens 261-264 29671340-4 2018 The results showed that indirubin and isatin, individually or combined, significantly inhibited weight loss, lowered disease activity index (DAI), ameliorated pathological changes, decreased the levels of pro-inflammatory mediators and myeloperoxidase (MPO) activity, increased the expression of anti-inflammatory cytokines and Foxp3, suppressed CD4+ T cell infiltration, and inhibited oxidative stress and epithelial cell apoptosis. Isatin 38-44 myeloperoxidase Mus musculus 236-251 30697888-2 2019 Reported here is an unprecedented auto-tandem cooperative catalysis (ATCC) for Morita-Baylis-Hillman carbonates from isatins and allylic carbonates using a simple Pd(PPh3 )4 precursor. Isatin 117-124 protein phosphatase 4 catalytic subunit Homo sapiens 166-170 30767538-0 2019 NHC-Catalyzed Aldol-Like Reactions of Allenoates with Isatins: Regiospecific Syntheses of gamma-Functionalized Allenoates. Isatin 54-61 high mobility group nucleosomal binding domain 4 Homo sapiens 0-3 30767538-1 2019 An N-heterocyclic carbene (NHC) catalyzed gamma-specific aldol-like reaction between allenoates and isatins has been achieved under mild conditions, giving trisubstituted allene derivatives bearing isatin moiety in moderate to good yields with high diastereoselectivity and excellent atom efficiency. Isatin 100-107 high mobility group nucleosomal binding domain 4 Homo sapiens 27-30 30767538-1 2019 An N-heterocyclic carbene (NHC) catalyzed gamma-specific aldol-like reaction between allenoates and isatins has been achieved under mild conditions, giving trisubstituted allene derivatives bearing isatin moiety in moderate to good yields with high diastereoselectivity and excellent atom efficiency. Isatin 100-106 high mobility group nucleosomal binding domain 4 Homo sapiens 27-30 30792039-1 2019 Herein we report our efforts of developing reversible selective hMAO-B inhibitors based on isatin, a fragment in an X-ray crystal structure. Isatin 91-97 monoamine oxidase B Homo sapiens 64-70 30792039-4 2019 However, the endeavors to modify the polar 3-one group of isatin, that is in a hydrophobic environment in the binding site of hMAO-B, to small nonpolar hydrophobic groups did not bring about improved hMAO-B inhibitors, which may challenge our understanding of molecular interactions and molecular recognition in biological systems. Isatin 58-64 monoamine oxidase B Homo sapiens 126-132 30768094-4 2019 Thus, indole derivatives presented a ligand-to-ligand-charge-transfer transition (LLCT) from the indole to the PPh3 fragment, whereas for the isatin derivatives an intraligand-charge-transfer transition (ILCT) within the isatin fragment is proposed. Isatin 142-148 caveolin 1 Homo sapiens 111-115 30445264-5 2019 Molecular docking of the designed hybrids in CA IX active site unveiled, as planned, the ability of N-alkylated and N-benzylated isatin moieties to accommodate in a wide hydrophobic pocket formed by T73, P75, P76, L91, L123 and A128, establishing strong van der Waals interactions. Isatin 129-135 carbonic anhydrase 9 Homo sapiens 45-50 30445264-5 2019 Molecular docking of the designed hybrids in CA IX active site unveiled, as planned, the ability of N-alkylated and N-benzylated isatin moieties to accommodate in a wide hydrophobic pocket formed by T73, P75, P76, L91, L123 and A128, establishing strong van der Waals interactions. Isatin 129-135 PC4 and SFRS1 interacting protein 1 Homo sapiens 204-207 30445264-5 2019 Molecular docking of the designed hybrids in CA IX active site unveiled, as planned, the ability of N-alkylated and N-benzylated isatin moieties to accommodate in a wide hydrophobic pocket formed by T73, P75, P76, L91, L123 and A128, establishing strong van der Waals interactions. Isatin 129-135 phospholipase B domain containing 2 Homo sapiens 209-212 30257379-10 2018 To the best of our knowledge this is the first report on the FAAH inhibitory properties of isatin-based analogs, revealing that both indoline skeleton and heteroaryl substitution at C-3 can modulate the activity of FAAH enzyme. Isatin 91-97 fatty acid amide hydrolase Homo sapiens 61-65 30257379-10 2018 To the best of our knowledge this is the first report on the FAAH inhibitory properties of isatin-based analogs, revealing that both indoline skeleton and heteroaryl substitution at C-3 can modulate the activity of FAAH enzyme. Isatin 91-97 fatty acid amide hydrolase Homo sapiens 215-219 29671340-4 2018 The results showed that indirubin and isatin, individually or combined, significantly inhibited weight loss, lowered disease activity index (DAI), ameliorated pathological changes, decreased the levels of pro-inflammatory mediators and myeloperoxidase (MPO) activity, increased the expression of anti-inflammatory cytokines and Foxp3, suppressed CD4+ T cell infiltration, and inhibited oxidative stress and epithelial cell apoptosis. Isatin 38-44 myeloperoxidase Mus musculus 253-256 29671340-4 2018 The results showed that indirubin and isatin, individually or combined, significantly inhibited weight loss, lowered disease activity index (DAI), ameliorated pathological changes, decreased the levels of pro-inflammatory mediators and myeloperoxidase (MPO) activity, increased the expression of anti-inflammatory cytokines and Foxp3, suppressed CD4+ T cell infiltration, and inhibited oxidative stress and epithelial cell apoptosis. Isatin 38-44 forkhead box P3 Mus musculus 328-333 29870246-1 2018 Herein, we report a chemoselective P(NMe2)3-mediated reductive epoxidation of alpha-dicarbonyl compounds such as isatins, alpha-keto esters, and alpha-diketones with aldehydes and ketones, leading to an efficient synthesis of a wide range of highly functionalized unsymmetrical epoxides in moderate to excellent yields and diastereoselectivities. Isatin 113-120 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 37-41 30136587-0 2018 N, N"-Dioxide/Gd(OTf)3 Complex-Promoted Asymmetric Aldol Reaction of Silyl Ketene Imines with Isatins: Water Plays an Important Role. Isatin 94-101 POU class 5 homeobox 1 Homo sapiens 17-22 29803079-0 2018 Synthesis, SAR elucidations and molecular docking study of newly designed isatin based oxadiazole analogs as potent inhibitors of thymidine phosphorylase. Isatin 74-80 sarcosine dehydrogenase Homo sapiens 11-14 30378558-0 2018 [The effect of the neuroprotector isatin on complex formation of beta-amyloid peptide fragments with some intracellular proteins]. Isatin 34-40 amyloid beta precursor protein Homo sapiens 65-85 30378558-4 2018 The aim of this study was to investigate the effect of the neuroprotector isatin (100 mM) on interaction of known Abeta-binding proteins, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase, with Abeta1-42 and its fragments (Abeta1-28, Abeta12-28, Abeta25-35). Isatin 74-80 amyloid beta precursor protein Homo sapiens 114-119 30378558-4 2018 The aim of this study was to investigate the effect of the neuroprotector isatin (100 mM) on interaction of known Abeta-binding proteins, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase, with Abeta1-42 and its fragments (Abeta1-28, Abeta12-28, Abeta25-35). Isatin 74-80 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 138-178 30378558-4 2018 The aim of this study was to investigate the effect of the neuroprotector isatin (100 mM) on interaction of known Abeta-binding proteins, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase, with Abeta1-42 and its fragments (Abeta1-28, Abeta12-28, Abeta25-35). Isatin 74-80 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 180-185 30378558-7 2018 The presence of 100 mM isatin caused a significant (more than fivefold) increase in the Kd values for GAPDH complexes with all Abeta peptides except Abeta1-28. Isatin 23-29 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 102-107 30378558-7 2018 The presence of 100 mM isatin caused a significant (more than fivefold) increase in the Kd values for GAPDH complexes with all Abeta peptides except Abeta1-28. Isatin 23-29 amyloid beta precursor protein Homo sapiens 127-132 30378558-9 2018 It should be noted that in the presence of isatin the Kd values for GAPDH and pyruvate kinase complexes with all Abeta studied were in a narrower concentration range (10-7 M - 10-6 M) than in the absence of this neuroprotector (10-8 M - 10-6 M). Isatin 43-49 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 68-73 30378558-9 2018 It should be noted that in the presence of isatin the Kd values for GAPDH and pyruvate kinase complexes with all Abeta studied were in a narrower concentration range (10-7 M - 10-6 M) than in the absence of this neuroprotector (10-8 M - 10-6 M). Isatin 43-49 amyloid beta precursor protein Homo sapiens 113-118 29648434-3 2018 Theoretical simulation and LDI detection of indigo and isatin molecules in negative ion mode revealed that the electric field can be enhanced on the tip end of SiNWs, thereby promoting the energy and electron transfer to the analytes adsorbed on the tip of SiNWs. Isatin 55-61 TOR signaling pathway regulator Homo sapiens 149-152 29648434-3 2018 Theoretical simulation and LDI detection of indigo and isatin molecules in negative ion mode revealed that the electric field can be enhanced on the tip end of SiNWs, thereby promoting the energy and electron transfer to the analytes adsorbed on the tip of SiNWs. Isatin 55-61 TOR signaling pathway regulator Homo sapiens 250-253 29472125-0 2018 Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors. Isatin 13-19 D-amino acid oxidase Mus musculus 55-75 29472125-0 2018 Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors. Isatin 13-19 D-amino acid oxidase Mus musculus 77-81 29472125-2 2018 Inhibitors of DAAO were sought testing [6+5] type heterocycles and identified isatin derivatives as micromolar DAAO inhibitors. Isatin 78-84 D-amino acid oxidase Mus musculus 14-18 29472125-2 2018 Inhibitors of DAAO were sought testing [6+5] type heterocycles and identified isatin derivatives as micromolar DAAO inhibitors. Isatin 78-84 D-amino acid oxidase Mus musculus 111-115 29472125-3 2018 A pharmacophore and structure-activity relationship analysis of isatins and reported DAAO inhibitors led us to investigate 1H-indazol-3-ol derivatives and nanomolar inhibitors were identified. Isatin 64-71 D-amino acid oxidase Mus musculus 85-89 29298039-10 2018 Using the MEA sensor, the limit of detection (LOD, (3sigma)/m) for isatin was found to be 0.04 muM; an increase to 0.22 muM was observed with the MAC sensor. Isatin 67-73 latexin Homo sapiens 95-98 29336068-10 2018 Physiological concentrations of isatin in vitro inhibit monoamine oxidase B and natriuretic peptide receptor guanylate cyclase, higher (neuroprotective) concentrations (50-400 muM) cause apoptosis of various (including malignant tumor) cell lines and influence expression of certain apoptosis-related genes. Isatin 32-38 monoamine oxidase B Rattus norvegicus 56-75 29355329-2 2018 The very remote zeta,eta-alkenes perform as effective HOMO-raised dienophiles in inverse-electron-demand oxa-Diels-Alder cycloadditions with isatin-derived oxadiene substrates, delivering multifunctional spirocyclic oxindoles incorporating a dihydropyran skeleton in moderate to high yields with good to excellent enantio- and diastereoselectivity. Isatin 141-147 endothelin receptor type A Homo sapiens 17-20 29460836-4 2018 In this work, an attempt has been undertaken to register a direct interaction of isatin with a set of different proteins related to the functioning of cytochrome P450-dependent monooxygenase: five isoforms of cytochromes P450, two isoforms of cytochrome b5, cytochrome P450 reductase, adrenodoxin, adrenodoxin reductase and ferrochelatase. Isatin 81-87 ferredoxin reductase Homo sapiens 298-319 30109812-0 2018 Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis. Isatin 6-12 tumor protein p53 Homo sapiens 40-43 30109812-0 2018 Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis. Isatin 6-12 MDM2 proto-oncogene Homo sapiens 66-70 29151266-5 2018 A more detailed biochemical and catalytic characterization shows that DHRS4_CAEEL shares some properties with human DHRS4 such as relatively low substrate affinities with aliphatic alpha-diketones and a preference for aromatic dicarbonyls such as isatin, with a 30-fold lower Km value compared with the human enzyme. Isatin 247-253 Dehydrogenase/reductase SDR family member 4 Caenorhabditis elegans 70-75 29151266-5 2018 A more detailed biochemical and catalytic characterization shows that DHRS4_CAEEL shares some properties with human DHRS4 such as relatively low substrate affinities with aliphatic alpha-diketones and a preference for aromatic dicarbonyls such as isatin, with a 30-fold lower Km value compared with the human enzyme. Isatin 247-253 dehydrogenase/reductase 4 Homo sapiens 116-121 29460836-4 2018 In this work, an attempt has been undertaken to register a direct interaction of isatin with a set of different proteins related to the functioning of cytochrome P450-dependent monooxygenase: five isoforms of cytochromes P450, two isoforms of cytochrome b5, cytochrome P450 reductase, adrenodoxin, adrenodoxin reductase and ferrochelatase. Isatin 81-87 ferrochelatase Homo sapiens 324-338 28738722-0 2017 Effects of indirubin and isatin on cell viability, mutagenicity, genotoxicity and BAX/ERCC1 gene expression. Isatin 25-31 BCL2 associated X, apoptosis regulator Homo sapiens 82-85 29082414-1 2017 A highly efficient TMSOTf-mediated asymmetric acetate-Mannich reaction of isatin derived tert-butylsulfinyl ketimines and S-phenyl thioacetate was developed to afford the direct synthesis of indole-based beta3,3-amino acid thioester with excellent selectivity (dr > 98 : 2). Isatin 74-80 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 204-211 28905435-0 2017 Isatin-induced increase in the affinity of human ferrochelatase and adrenodoxin reductase interaction. Isatin 0-6 ferrochelatase Homo sapiens 49-63 28905435-0 2017 Isatin-induced increase in the affinity of human ferrochelatase and adrenodoxin reductase interaction. Isatin 0-6 ferredoxin reductase Homo sapiens 68-89 28905435-4 2017 In this surface plasmon resonance-based biosensor study we have found that physiologically relevant concentrations of isatin (25-100 muM) increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH-dependent adrenodoxin reductase (ADR). Isatin 118-124 ferrochelatase Homo sapiens 198-212 28905435-4 2017 In this surface plasmon resonance-based biosensor study we have found that physiologically relevant concentrations of isatin (25-100 muM) increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH-dependent adrenodoxin reductase (ADR). Isatin 118-124 ferrochelatase Homo sapiens 214-218 28905435-4 2017 In this surface plasmon resonance-based biosensor study we have found that physiologically relevant concentrations of isatin (25-100 muM) increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH-dependent adrenodoxin reductase (ADR). Isatin 118-124 ferredoxin reductase Homo sapiens 240-261 28905435-4 2017 In this surface plasmon resonance-based biosensor study we have found that physiologically relevant concentrations of isatin (25-100 muM) increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH-dependent adrenodoxin reductase (ADR). Isatin 118-124 aldo-keto reductase family 1 member B Homo sapiens 263-266 28905435-6 2017 It is especially important that the interaction of isatin with each individual protein (FECH, ADR) was basically negligible and therefore could not contribute to the observed effect. Isatin 51-57 ferrochelatase Homo sapiens 88-92 29058439-0 2017 Rh(II)-Catalyzed Denitrogenative Reaction of N-Sulfonyl-1,2,3-triazoles with Isatins for the Construction of Indigoids. Isatin 77-84 Rh blood group D antigen Homo sapiens 0-6 29058439-1 2017 A convenient, Rh(II)-catalyzed, denitrogenative reaction of N-sulfonyl-1,2,3-triazoles and isatins to access (E)-2-(1-amino-2-oxo-2-phenylethylidene)indolin-3-ones, the core structure of indigo dyes, was achieved under operationally simple conditions with high levels of diastereoselectivity. Isatin 91-98 Rh blood group D antigen Homo sapiens 14-19 28956607-0 2017 P(NMe2)3-Mediated Reductive (1 + 4) Annulation Reaction of Isatins with Nitroalkenes: An Access to Spirooxindolyl Isoxazoline N-Oxides and Their Corresponding Isoxazolines. Isatin 59-66 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 2-6 28956607-2 2017 This reaction presumably proceeds through a Michael addition-intramolecular substitution sequence via active in situ generated Kukhtin-Ramirez zwitterions from isatins and P(NMe2)3. Isatin 160-167 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 174-178 29340222-6 2017 Importantly, the TBXAS1 CYP2E1 complex formation increases fivefold in the presence of isatin (indole-2,3-dione, a low-molecular nonpeptide endogenous bioregulator, a product of CYP2E1). Isatin 87-93 thromboxane A synthase 1 Homo sapiens 17-23 29340222-6 2017 Importantly, the TBXAS1 CYP2E1 complex formation increases fivefold in the presence of isatin (indole-2,3-dione, a low-molecular nonpeptide endogenous bioregulator, a product of CYP2E1). Isatin 87-93 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 24-30 29340222-6 2017 Importantly, the TBXAS1 CYP2E1 complex formation increases fivefold in the presence of isatin (indole-2,3-dione, a low-molecular nonpeptide endogenous bioregulator, a product of CYP2E1). Isatin 87-93 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 178-184 29340222-6 2017 Importantly, the TBXAS1 CYP2E1 complex formation increases fivefold in the presence of isatin (indole-2,3-dione, a low-molecular nonpeptide endogenous bioregulator, a product of CYP2E1). Isatin 95-111 thromboxane A synthase 1 Homo sapiens 17-23 29340222-6 2017 Importantly, the TBXAS1 CYP2E1 complex formation increases fivefold in the presence of isatin (indole-2,3-dione, a low-molecular nonpeptide endogenous bioregulator, a product of CYP2E1). Isatin 95-111 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 24-30 29340222-6 2017 Importantly, the TBXAS1 CYP2E1 complex formation increases fivefold in the presence of isatin (indole-2,3-dione, a low-molecular nonpeptide endogenous bioregulator, a product of CYP2E1). Isatin 95-111 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 178-184 28379899-0 2017 Isatin inhibits SH-SY5Y neuroblastoma cell invasion and metastasis through MAO/HIF-1alpha/CXCR4 signaling. Isatin 0-6 hypoxia inducible factor 1 subunit alpha Homo sapiens 79-89 28816452-0 2017 Active sp3 C-H Bond Oxidation Initiated sp3-sp2 Consecutive C-H Functionalization of N-Arylglycine Amides: Construction of Isatins. Isatin 123-130 Sp3 transcription factor Homo sapiens 7-10 28816452-0 2017 Active sp3 C-H Bond Oxidation Initiated sp3-sp2 Consecutive C-H Functionalization of N-Arylglycine Amides: Construction of Isatins. Isatin 123-130 Sp3 transcription factor Homo sapiens 40-43 28816452-0 2017 Active sp3 C-H Bond Oxidation Initiated sp3-sp2 Consecutive C-H Functionalization of N-Arylglycine Amides: Construction of Isatins. Isatin 123-130 Sp2 transcription factor Homo sapiens 44-47 28816452-1 2017 In the presence of catalytic triarylamine radical cation, an sp3-sp2 consecutive C-H functionalization of N-arylglycine amides was achieved, providing a series of isatin derivatives in high yields. Isatin 163-169 Sp3 transcription factor Homo sapiens 61-64 28816452-1 2017 In the presence of catalytic triarylamine radical cation, an sp3-sp2 consecutive C-H functionalization of N-arylglycine amides was achieved, providing a series of isatin derivatives in high yields. Isatin 163-169 Sp2 transcription factor Homo sapiens 65-68 28450226-1 2017 Human carbonyl reductase 1 (CBR1), a member of the short-chain dehydrogenase/reductase (SDR) superfamily, reduces a variety of carbonyl compounds including endogenous isatin, prostaglandin E2 and 4-oxo-2-nonenal. Isatin 167-173 carbonyl reductase 1 Homo sapiens 6-26 28450226-1 2017 Human carbonyl reductase 1 (CBR1), a member of the short-chain dehydrogenase/reductase (SDR) superfamily, reduces a variety of carbonyl compounds including endogenous isatin, prostaglandin E2 and 4-oxo-2-nonenal. Isatin 167-173 carbonyl reductase 1 Homo sapiens 28-32 28379899-0 2017 Isatin inhibits SH-SY5Y neuroblastoma cell invasion and metastasis through MAO/HIF-1alpha/CXCR4 signaling. Isatin 0-6 C-X-C motif chemokine receptor 4 Homo sapiens 90-95 28379899-4 2017 Moreover, isatin inhibited the expression level of monoamine oxidase A as well as that of its downstream protein hypoxia-inducible factor 1alpha. Isatin 10-16 monoamine oxidase A Homo sapiens 51-70 28379899-4 2017 Moreover, isatin inhibited the expression level of monoamine oxidase A as well as that of its downstream protein hypoxia-inducible factor 1alpha. Isatin 10-16 hypoxia inducible factor 1 subunit alpha Homo sapiens 113-144 28506067-0 2017 PPh3 Mediated Reductive Annulation Reaction between Isatins and Electron Deficient Dienes to Construct Spirooxindole Compounds. Isatin 52-59 caveolin 1 Homo sapiens 0-4 28604855-1 2017 A novel P(NMe2)3-mediated formal carbon-halogen bond insertion of isatins into allylic and benzylic bromides/chlorides has been realized, leading to a facile synthesis of 3-halo 3,3"-disubstituted oxindoles. Isatin 66-73 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 10-14 28775867-7 2017 The title compound and the selected biological target VEGFR-2 show the N-H O(GLU94), (CYS96)N-H O(isatine) and (PHE95)N-H O(isatine) inter-molecular inter-actions, which suggests a solid theoretical structure-activity relationship. Isatin 98-105 kinase insert domain receptor Homo sapiens 54-61 28775867-7 2017 The title compound and the selected biological target VEGFR-2 show the N-H O(GLU94), (CYS96)N-H O(isatine) and (PHE95)N-H O(isatine) inter-molecular inter-actions, which suggests a solid theoretical structure-activity relationship. Isatin 124-131 kinase insert domain receptor Homo sapiens 54-61 28506067-1 2017 A PPh3 mediated reductive annulation reaction between isatins and 4,4-dicyano-2-methylenebut-3-enoates was developed. Isatin 54-61 caveolin 1 Homo sapiens 2-6 28414290-0 2017 [The effect of isatin on protein-protein interactions between cytochrome b5 and cytochromes P450]. Isatin 15-21 cytochrome b5 type A Homo sapiens 62-75 28320274-6 2017 Administration of isatin to mice prevented MPTP-induced inactivation of MAO B and influenced the profile of brain mitochondrial Rpn10-binding proteins, in which two pools of proteins were clearly recognized. Isatin 18-24 monoamine oxidase B Mus musculus 72-77 28414290-2 2017 Since some CYP catalyze indol oxidation to isatin, we have hypothesized that isatin can regulate protein-protein interactions (PPI) between components of the CYP system thus representing a (negative?) Isatin 43-49 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 158-161 28414290-2 2017 Since some CYP catalyze indol oxidation to isatin, we have hypothesized that isatin can regulate protein-protein interactions (PPI) between components of the CYP system thus representing a (negative?) Isatin 77-83 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 11-14 28414290-2 2017 Since some CYP catalyze indol oxidation to isatin, we have hypothesized that isatin can regulate protein-protein interactions (PPI) between components of the CYP system thus representing a (negative?) Isatin 77-83 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 158-161 28414290-4 2017 The aim of this study was to investigate a possible effect of isatin on interaction of human CYP with cytochrome b5 (CYB5A). Isatin 62-68 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 93-96 28414290-4 2017 The aim of this study was to investigate a possible effect of isatin on interaction of human CYP with cytochrome b5 (CYB5A). Isatin 62-68 cytochrome b5 type A Homo sapiens 102-115 28414290-4 2017 The aim of this study was to investigate a possible effect of isatin on interaction of human CYP with cytochrome b5 (CYB5A). Isatin 62-68 cytochrome b5 type A Homo sapiens 117-122 28414290-6 2017 The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1). Isatin 66-72 cytochrome b5 type A Homo sapiens 116-121 28414290-6 2017 The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1). Isatin 66-72 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 122-128 28414290-6 2017 The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1). Isatin 66-72 cytochrome b5 type A Homo sapiens 133-138 28414290-6 2017 The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1). Isatin 66-72 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 139-145 28414290-6 2017 The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1). Isatin 66-72 cytochrome b5 type A Homo sapiens 133-138 28414290-6 2017 The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1). Isatin 66-72 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 122-125 28414290-6 2017 The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1). Isatin 66-72 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 285-292 28414290-6 2017 The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1). Isatin 66-72 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 297-303 28414290-7 2017 Isatin injection to the optical biosensor chip with the preformed molecular complex CYB5A/CYP3A4 caused a 30%-increase in its dissociation rate. Isatin 0-6 cytochrome b5 type A Homo sapiens 84-89 28414290-7 2017 Isatin injection to the optical biosensor chip with the preformed molecular complex CYB5A/CYP3A4 caused a 30%-increase in its dissociation rate. Isatin 0-6 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 90-96 28414290-8 2017 Molecular docking manipulations have shown that isatin can influence interaction of CYP3A5 or CYP3A4 with CYB5A acting at the contact region of CYB5A/CYP. Isatin 48-54 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 84-90 28414290-8 2017 Molecular docking manipulations have shown that isatin can influence interaction of CYP3A5 or CYP3A4 with CYB5A acting at the contact region of CYB5A/CYP. Isatin 48-54 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 94-100 28414290-8 2017 Molecular docking manipulations have shown that isatin can influence interaction of CYP3A5 or CYP3A4 with CYB5A acting at the contact region of CYB5A/CYP. Isatin 48-54 cytochrome b5 type A Homo sapiens 106-111 28414290-8 2017 Molecular docking manipulations have shown that isatin can influence interaction of CYP3A5 or CYP3A4 with CYB5A acting at the contact region of CYB5A/CYP. Isatin 48-54 cytochrome b5 type A Homo sapiens 144-149 28414290-8 2017 Molecular docking manipulations have shown that isatin can influence interaction of CYP3A5 or CYP3A4 with CYB5A acting at the contact region of CYB5A/CYP. Isatin 48-54 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 84-87 27998005-6 2017 These sex differences were eliminated by a treatment with isatin, a non-selective MAO inhibitor, and moclobemide, a selective MAOA inhibitor, but not by selegiline, a selective MAOB inhibitor. Isatin 58-64 monoamine oxidase A Rattus norvegicus 82-85 27374845-0 2016 Effects and mechanism of action of isatin, a MAO inhibitor, on in vivo striatal dopamine release. Isatin 35-41 monoamine oxidase A Rattus norvegicus 45-48 29449910-2 2017 The preliminary evaluation studies revealed the compound 4t, with an optimal combination of bromo-substituent at the C-5 position of isatin ring along with propyl chain linker being most active among the synthesized series exhibiting an IC50 value of 3.72 muM against Trichomonas vaginalis while 4j exhibited an IC50 value of 14.8 muM against Naegleria fowleri, more effective than the standard drug Miltefosine. Isatin 133-139 complement C5 Homo sapiens 117-120 27374845-1 2016 Isatin is an endogenous indole that inhibits monoamine oxidase (MAO), being more selective for MAO-B than MAO-A isoform. Isatin 0-6 monoamine oxidase A Rattus norvegicus 45-62 27374845-1 2016 Isatin is an endogenous indole that inhibits monoamine oxidase (MAO), being more selective for MAO-B than MAO-A isoform. Isatin 0-6 monoamine oxidase A Rattus norvegicus 64-67 27374845-1 2016 Isatin is an endogenous indole that inhibits monoamine oxidase (MAO), being more selective for MAO-B than MAO-A isoform. Isatin 0-6 monoamine oxidase B Rattus norvegicus 95-100 27374845-1 2016 Isatin is an endogenous indole that inhibits monoamine oxidase (MAO), being more selective for MAO-B than MAO-A isoform. Isatin 0-6 monoamine oxidase A Rattus norvegicus 106-111 27374845-2 2016 By inhibiting MAO, isatin increases dopamine levels in the brain and, in animal models of Parkinson"s disease (PD) isatin is able to prevent dopamine depletion. Isatin 19-25 monoamine oxidase A Rattus norvegicus 14-17 27092477-7 2016 The higher iNOS inhibition activity of the tested Schiff bases, relative to that of COX-2, seems to be a reflection of the combined suppressive effects exerted by their nalidixic acid, isatins (4a-c), and l-amino acid moieties against iNOS expression. Isatin 185-192 nitric oxide synthase 2, inducible Mus musculus 11-15 27233608-2 2016 In the present study we deciphered the mechanisms of action of URM-II-81, a new derivative of isatin, in alleviation of insulin resistance in human hepatocytes and murine adipocytes. Isatin 94-100 insulin Homo sapiens 120-127 26734722-1 2016 A chiral complex derived from (S)-difluorophos and Hg(OTf)2 is identified as a powerful catalyst for the Sakurai-Hosomi reaction of isatins with allyltrimethylsilane, allowing the facile synthesis of valuable building blocks 3-allyl-3-hydroxyoxindoles in up to 97% ee, with only 0.5-1.0 mol% of catalyst loading. Isatin 132-139 POU class 2 homeobox 2 Homo sapiens 54-59 27374845-2 2016 By inhibiting MAO, isatin increases dopamine levels in the brain and, in animal models of Parkinson"s disease (PD) isatin is able to prevent dopamine depletion. Isatin 115-121 monoamine oxidase A Rattus norvegicus 14-17 26846278-6 2016 These results demonstrated that isatin induces G1-phase arrest in SH-SY5Y cells, possibly by decreasing cyclin D1 expression as well as inhibiting their migration and invasiveness, probably by reducing MMP2 and MMP9. Isatin 32-38 matrix metallopeptidase 9 Homo sapiens 211-215 27143373-0 2016 [Oxidative modification of glyceraldehyde-3-phosphate dehydrogenase influences its interaction with endogenous neuroprotector isatin]. Isatin 126-132 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 27-67 27143373-2 2016 GAPDH binds isatin (indole-dione-2,3), an endogenous indole often used as a parent component in numerous derivatives demonstrating diverse pharmacological (including neuroprotector) activities. Isatin 12-18 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-5 27143373-3 2016 In this study we have investigated binding of intact and mildly oxidized GAPDH to immobilized isatin, using an optical biosensor technique, employing surface plasmon resonance (SPR), and the effect of isatin as a probe for this binding. Isatin 94-100 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 73-78 27143373-4 2016 Mild GAPDH oxidation by 70 mM H(2)O(2) increased enzyme dissociation from immobilized isatin. Isatin 86-92 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 5-10 27441242-0 2016 N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines. Isatin 12-19 ATP binding cassette subfamily B member 1 Homo sapiens 26-30 27441242-6 2016 We show that one mechanism by which the isatin-based compounds overcome MDR is by circumventing P-glycoprotein (P-gp) mediated drug efflux. Isatin 40-46 ATP binding cassette subfamily B member 1 Homo sapiens 96-110 27441242-6 2016 We show that one mechanism by which the isatin-based compounds overcome MDR is by circumventing P-glycoprotein (P-gp) mediated drug efflux. Isatin 40-46 ATP binding cassette subfamily B member 1 Homo sapiens 112-116 26519157-14 2015 Novel bis-Schiff base of isatin showed significant antioxidant activity and also reduced receptor for AGEs (RAGE) expression and PKC-alpha activation therefore; MK-I-81 reduces AGEs induced insulin resistance. Isatin 25-31 advanced glycosylation end product-specific receptor Mus musculus 108-112 26846278-3 2016 The results demonstrated that the proportion of SH-SY5Y cells in G1 phase was significantly increased following treatment with isatin for 48 h with simultaneous downregulation of cyclin D1 expression. Isatin 127-133 cyclin D1 Homo sapiens 179-188 26846278-4 2016 In addition, isatin significantly inhibited cell migration and invasion, along with decreases in matrix metalloproteinase (MMP)2 and MMP9 expression. Isatin 13-19 matrix metallopeptidase 2 Homo sapiens 97-128 26846278-4 2016 In addition, isatin significantly inhibited cell migration and invasion, along with decreases in matrix metalloproteinase (MMP)2 and MMP9 expression. Isatin 13-19 matrix metallopeptidase 9 Homo sapiens 133-137 26846278-5 2016 In addition, isatin reduced the levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in a concentration-dependent manner. Isatin 13-19 signal transducer and activator of transcription 3 Homo sapiens 57-107 26846278-6 2016 These results demonstrated that isatin induces G1-phase arrest in SH-SY5Y cells, possibly by decreasing cyclin D1 expression as well as inhibiting their migration and invasiveness, probably by reducing MMP2 and MMP9. Isatin 32-38 cyclin D1 Homo sapiens 104-113 26846278-6 2016 These results demonstrated that isatin induces G1-phase arrest in SH-SY5Y cells, possibly by decreasing cyclin D1 expression as well as inhibiting their migration and invasiveness, probably by reducing MMP2 and MMP9. Isatin 32-38 matrix metallopeptidase 2 Homo sapiens 202-206 27096472-5 2016 Hydrogen bond interactions between the compound and key active site residues of TDO, freedom upon rotation of the C3 chemical moiety and the presence of chlorines in the benzene ring of the compound comprise the properties that an isatin-based inhibitor requires to effectively inhibit the enzymatic activity of TDO. Isatin 231-237 tryptophan 2,3-dioxygenase Homo sapiens 80-83 27096472-5 2016 Hydrogen bond interactions between the compound and key active site residues of TDO, freedom upon rotation of the C3 chemical moiety and the presence of chlorines in the benzene ring of the compound comprise the properties that an isatin-based inhibitor requires to effectively inhibit the enzymatic activity of TDO. Isatin 231-237 tryptophan 2,3-dioxygenase Homo sapiens 312-315 26515041-1 2015 Keeping in view the limitations associated with currently available anticancer drugs, molecular hybrids of mono carbonyl curcumin and isatin tethered by triazole ring have been synthesized and evaluated for in vitro cytotoxicity against THP-1, COLO-205, HCT-116, A549, HeLa, CAKI-I, PC-3, MiaPaca-2 human cancer cell lines. Isatin 134-140 GLI family zinc finger 2 Homo sapiens 237-242 27096472-0 2016 Insights into the mechanism of inhibition of tryptophan 2,3-dioxygenase by isatin derivatives. Isatin 75-81 tryptophan 2,3-dioxygenase Homo sapiens 45-71 27096472-3 2016 Herein, we report isatin derivatives as a new class of TDO inhibitors. Isatin 18-24 tryptophan 2,3-dioxygenase Homo sapiens 55-58 26519157-14 2015 Novel bis-Schiff base of isatin showed significant antioxidant activity and also reduced receptor for AGEs (RAGE) expression and PKC-alpha activation therefore; MK-I-81 reduces AGEs induced insulin resistance. Isatin 25-31 protein kinase C, alpha Mus musculus 129-138 25891478-1 2015 Isatin is an endogenous inhibitor of monoamine oxidase B and is found in human blood and tissue. Isatin 0-6 monoamine oxidase B Homo sapiens 37-56 26408817-5 2015 Compounds 11e and 16e, with 5-NO2 substitution on the isatin ring, were found to be selective inhibitors of hCA IX and hCA XII. Isatin 54-60 carbonic anhydrase 9 Homo sapiens 108-126 26291733-0 2015 P(NMe2)3-mediated reductive [1+4] annulation of isatins with enones: a facile synthesis of spirooxindole-dihydrofurans. Isatin 48-55 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 2-6 26291733-1 2015 A novel P(NMe2)3-mediated reductive [1+4] annulation reaction between isatins and enones has been developed, providing the facile synthesis of spirooxindole-dihydrofurans. Isatin 70-77 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 10-14 26154082-1 2015 Screening a library of small-molecule compounds using a cell line expressing human GABA transporter 3 (hGAT3) in a [(3)H]GABA uptake assay identified isatin derivatives as a new class of hGAT3 inhibitors. Isatin 150-156 solute carrier family 6 member 11 Homo sapiens 83-101 26154082-1 2015 Screening a library of small-molecule compounds using a cell line expressing human GABA transporter 3 (hGAT3) in a [(3)H]GABA uptake assay identified isatin derivatives as a new class of hGAT3 inhibitors. Isatin 150-156 solute carrier family 6 member 11 Homo sapiens 103-108 26154082-1 2015 Screening a library of small-molecule compounds using a cell line expressing human GABA transporter 3 (hGAT3) in a [(3)H]GABA uptake assay identified isatin derivatives as a new class of hGAT3 inhibitors. Isatin 150-156 solute carrier family 6 member 11 Homo sapiens 187-192 26307165-8 2015 We show in silico that NPR-C, a preferential CNP receptor, and the P. aeruginosa protein AmiC have similar three-dimensional (3D) structures and that both CNP and isatin bind to AmiC. Isatin 163-169 natriuretic peptide receptor 3 Homo sapiens 23-28 25955493-0 2015 Isatin based Schiff bases as inhibitors of alpha-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies. Isatin 0-6 sucrase-isomaltase Homo sapiens 43-60 26288684-0 2015 Discovery of Novel Isatin-Based p53 Inducers. Isatin 19-25 tumor protein p53 Homo sapiens 32-35 25344147-1 2015 PURPOSE: We tested whether positron emission tomography (PET) with the caspase-3-targeted isatin analog [(18)F]WC-4-116 could image caspase-3 activation in response to an apoptosis-inducing anticancer therapy. Isatin 90-96 caspase 3 Mus musculus 71-80 25344147-1 2015 PURPOSE: We tested whether positron emission tomography (PET) with the caspase-3-targeted isatin analog [(18)F]WC-4-116 could image caspase-3 activation in response to an apoptosis-inducing anticancer therapy. Isatin 90-96 caspase 3 Mus musculus 132-141 25698234-7 2015 BNPPost also significantly phosphorylated Akt and p70s6k at early reperfusion, and Akt phosphorylation was inhibited by SH-6 and isatin. Isatin 129-135 AKT serine/threonine kinase 1 Rattus norvegicus 83-86 25630891-1 2015 The highly enantioselective organocatalytic addition of ethyl nitroacetate to isatin-derived N-Boc ketimines (Boc = tert-butoxycarbonyl), followed by the removal of the nitro group, is described. Isatin 78-84 BOC cell adhesion associated, oncogene regulated Homo sapiens 95-98 25630891-1 2015 The highly enantioselective organocatalytic addition of ethyl nitroacetate to isatin-derived N-Boc ketimines (Boc = tert-butoxycarbonyl), followed by the removal of the nitro group, is described. Isatin 78-84 BOC cell adhesion associated, oncogene regulated Homo sapiens 110-113 25046380-5 2014 As many PAC-1 derivatives contain a zinc chelating ortho-hydroxy N-acyl hydrazone moiety and isatin derivatives has two carbonyl groups on the indole core, it was of interest to determine to which extent these compounds can inhibit MMPs. Isatin 93-99 dual specificity phosphatase 2 Homo sapiens 8-13 32287446-1 2015 Sulfonated-beta-cyclodextrin (beta-CD-SO3H) promoted efficient and fast electrophilic substitution reaction of indoles with various isatins reflux in water is reported affording various 3-indolyl-3-hydroxy oxindoles and 3,3-di(indolyl)indolin-2-ones in good to excellent yields in short reaction time. Isatin 132-139 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 30-37 24890564-2 2014 Structure-based virtual screening of about 3,000,000 commercially available compounds against the crystal structure of the glycosyltransferase (GT) domain of the Staphylococcus aureus penicillin-binding protein 2 (S. aureus PBP2) resulted in identification of an isatin derivative, 2-(3-(2-carbamimidoylhydrazono)-2-oxoindolin-1-yl)-N-(m-tolyl)acetamide (4) as a novel potential GT inhibitor. Isatin 263-269 AT695_RS10295 Staphylococcus aureus 184-212 25834908-0 2010 Development of the First CNS penetrant M5 Positive Allosteric Modulator (PAM) Based on a Novel, non-Isatin Core A recently completed functional, high throughput screen of the Molecular Libraries Probe Production Centers Network (MLPCN) screening deck of ~360,000 compounds conducted by SRIMSC against three of the five muscarinic receptor subtypes (M1, M4 and M5) provided a number of interesting hits. Isatin 100-106 cholinergic receptor muscarinic 5 Homo sapiens 39-41 25834908-2 2010 The most promising M5 PAM hit (CID 17516658), being particularly attractive due to the absence of the isatin core shared by all previous M5 PAMs, was quickly developed into a potent, selective and CNS penetrant probe molecule ML380 (hM5 PAM EC50 = 190 nM, hM5 ACh fold-shift = 9.3, rM5 PAM EC50 = 610 nM). Isatin 102-108 cholinergic receptor muscarinic 5 Homo sapiens 19-21 25174967-7 2014 Furthermore, Bcl-2 expression was decreased and the ratio of Bcl-2 to Bax was significantly decreased by isatin. Isatin 105-111 BCL2 apoptosis regulator Homo sapiens 13-18 25174967-7 2014 Furthermore, Bcl-2 expression was decreased and the ratio of Bcl-2 to Bax was significantly decreased by isatin. Isatin 105-111 BCL2 apoptosis regulator Homo sapiens 61-66 25174967-7 2014 Furthermore, Bcl-2 expression was decreased and the ratio of Bcl-2 to Bax was significantly decreased by isatin. Isatin 105-111 BCL2 associated X, apoptosis regulator Homo sapiens 70-73 25174967-8 2014 The mitochondrial transmembrane potential was markedly decreased and the release of cytochrome c into the cytosol was elevated following treatment with isatin. Isatin 152-158 cytochrome c, somatic Homo sapiens 84-96 25046380-6 2014 METHODS: Eight PAC-1 and five isatin derivatives were docked into MMP-9 and MMP-14. Isatin 30-36 matrix metallopeptidase 9 Homo sapiens 66-71 25046380-6 2014 METHODS: Eight PAC-1 and five isatin derivatives were docked into MMP-9 and MMP-14. Isatin 30-36 matrix metallopeptidase 14 Homo sapiens 76-82 24051284-1 2014 Complexes of manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) with a Schiff base, formed by the condensation of isatin with 2-aminopyrimidine have been synthesised and characterised through elemental analysis, molar conductance measurements, magnetic susceptibility, IR, UV-Vis, (1)HNMR, FAB mass and EPR spectral studies. Isatin 126-132 FA complementation group B Homo sapiens 302-305 24917679-3 2014 Isatin hydrolase converts isatin to isatinate and belongs to a novel family of metalloenzymes that include the bacterial kynurenine formamidase. Isatin 26-32 arylformamidase Homo sapiens 121-143 25108055-8 2014 CRF 9-41, antalarmin, astressin 2B haloperidol, atropine, noraminophenazone and isatin prevented the NmU-induced increase in colon temperature. Isatin 80-86 neuromedin U Rattus norvegicus 101-104 24316276-0 2014 Inhibition of tumor necrosis factor-alpha and cyclooxigenase-2 by Isatin: a molecular mechanism of protection against TNBS-induced colitis in rats. Isatin 66-72 tumor necrosis factor Rattus norvegicus 14-41 24316276-6 2014 Our main results showed that the oral treatment with Isatin 6 and 25 mg/kg were capable of avoiding the increase in TNF-alpha, COX-2 and PGE2 levels when compared to the colitic non-treated group. Isatin 53-59 tumor necrosis factor Rattus norvegicus 116-125 24316276-6 2014 Our main results showed that the oral treatment with Isatin 6 and 25 mg/kg were capable of avoiding the increase in TNF-alpha, COX-2 and PGE2 levels when compared to the colitic non-treated group. Isatin 53-59 cytochrome c oxidase II, mitochondrial Rattus norvegicus 127-132 23995665-5 2013 AKR1C5 also reduced various non-steroidal carbonyl compounds, including isatin, an antagonist of the C-type natriuretic peptide receptor, and 4-oxo-2-nonenal, suggesting its roles in controlling the bioactive isatin and detoxification of cytotoxic aldehydes. Isatin 72-78 prostaglandin-E(2) 9-reductase Oryctolagus cuniculus 0-6 23376416-9 2013 Furthermore, Bcl-2 expression was decreased and the ratio of Bcl-2 to Bax was significantly decreased by isatin. Isatin 105-111 BCL2 apoptosis regulator Homo sapiens 13-18 23376416-9 2013 Furthermore, Bcl-2 expression was decreased and the ratio of Bcl-2 to Bax was significantly decreased by isatin. Isatin 105-111 BCL2 apoptosis regulator Homo sapiens 61-66 23376416-9 2013 Furthermore, Bcl-2 expression was decreased and the ratio of Bcl-2 to Bax was significantly decreased by isatin. Isatin 105-111 BCL2 associated X, apoptosis regulator Homo sapiens 70-73 23376416-10 2013 The mitochondrial transmembrane potential was markedly reduced and the release of cytochrome c into the cytosol was increased after treatment with isatin. Isatin 147-153 cytochrome c, somatic Homo sapiens 82-94 23522833-1 2013 Cu(OTf)2 catalyzed efficient synthesis of spiropyrano[3,2-b]pyran-4(8H)-ones is accomplished via one-pot three component reaction between isatin, kojic acid and active methylenes. Isatin 138-144 POU class 2 homeobox 2 Homo sapiens 0-8 23247010-1 2013 Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous inhibitor of monoamine oxidases. Isatin 204-210 carbonyl reductase 1 Homo sapiens 10-30 23247010-1 2013 Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous inhibitor of monoamine oxidases. Isatin 204-210 carbonyl reductase 1 Homo sapiens 32-36 23247010-1 2013 Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous inhibitor of monoamine oxidases. Isatin 204-210 carbonyl reductase 1 Homo sapiens 38-45 23053004-5 2013 Obtained biological data could be well interpreted using docking binding energies toward vascular endothelial growth factor receptor (VEGFR-2); a key anticancer target being biologically investigated against various isatin derivatives. Isatin 216-222 kinase insert domain receptor Homo sapiens 134-141 23995665-5 2013 AKR1C5 also reduced various non-steroidal carbonyl compounds, including isatin, an antagonist of the C-type natriuretic peptide receptor, and 4-oxo-2-nonenal, suggesting its roles in controlling the bioactive isatin and detoxification of cytotoxic aldehydes. Isatin 209-215 prostaglandin-E(2) 9-reductase Oryctolagus cuniculus 0-6 23207410-4 2013 Moreover, partial recovery of MAO-B activity was observed after repeated washing in the presence of isatin (reversible inhibitor) and compounds 3g and 3h suggesting a reversible inhibition of the enzyme. Isatin 100-106 monoamine oxidase B Homo sapiens 30-35 23557234-3 2013 The 5 isatin concentrations evaluated in the mutagenicity and apoptosis tests were 0.5, 1, 5, 10, and 50 muM, selected through a preliminary MTT assay. Isatin 6-12 latexin Homo sapiens 105-108 24185378-4 2013 Generally in both series it was found that, compounds bearing no substituent or with 5"-F, 5"-Cl, 7"-Cl substitutents on the isatin moiety exhibited good inhibition against histone-H3 and histone-H4 deacetylation at the concentrations of 1 muM, as evaluated by Western Blot assay. Isatin 125-131 latexin Homo sapiens 240-243 24185378-8 2013 These findings should encourage further elaboration with the isatin moiety to produce more potent HDAC inhibitors with potential anticancer activity. Isatin 61-67 histone deacetylase 9 Homo sapiens 98-102 21920762-0 2011 Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway. Isatin 56-62 AKT serine/threonine kinase 1 Homo sapiens 120-123 21838297-3 2011 Virtual screening analysis inspired the evaluation of 19 commercially available isatin analogues and 13 newly synthesized isatin derivatives as novel AHAS inhibitors and for their herbicidal activity. Isatin 80-86 chlorsulfuron/imidazolinone resistant 1 Arabidopsis thaliana 150-154 21838297-3 2011 Virtual screening analysis inspired the evaluation of 19 commercially available isatin analogues and 13 newly synthesized isatin derivatives as novel AHAS inhibitors and for their herbicidal activity. Isatin 122-128 chlorsulfuron/imidazolinone resistant 1 Arabidopsis thaliana 150-154 21838297-7 2011 This is the first comprehensive study of isatin derivatives as AHAS inhibitors and provides a valuable starting point for the design of new herbicides. Isatin 41-47 chlorsulfuron/imidazolinone resistant 1 Arabidopsis thaliana 63-67 21778064-1 2011 Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B. Isatin 24-30 monoamine oxidase A Homo sapiens 117-148 21778064-1 2011 Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B. Isatin 65-71 monoamine oxidase A Homo sapiens 117-148 21778064-2 2011 In general, C5- and C6-substitution of isatin leads to enhanced binding affinity to both MAO isozymes compared to isatin and in most instances result in selective binding to the MAO-B isoform. Isatin 39-45 monoamine oxidase B Homo sapiens 178-183 21778064-3 2011 Crystallographic and modeling studies suggest that the isatin ring binds to the substrate cavities of MAO-A and -B and is stabilized by hydrogen bond interactions between the NH and the C2 carbonyl oxygen of the dioxoindolyl moiety and water molecules present in the substrate cavities of MAO-A and -B. Isatin 55-61 monoamine oxidase A Homo sapiens 102-114 21778064-3 2011 Crystallographic and modeling studies suggest that the isatin ring binds to the substrate cavities of MAO-A and -B and is stabilized by hydrogen bond interactions between the NH and the C2 carbonyl oxygen of the dioxoindolyl moiety and water molecules present in the substrate cavities of MAO-A and -B. Isatin 55-61 monoamine oxidase A Homo sapiens 289-301 21615156-2 2011 One very promising PET tracer is (S)-1-(4-(2-[(18)F]-fluoroethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (isatin), a caspase-3 inhibitor, which has been developed at the University Hospital of Munster to image cell death (apoptosis). Isatin 117-123 caspase 3 Rattus norvegicus 136-145 21073954-5 2011 Isatin inhibited the relaxation to ANP both in arteries with and without endothelium. Isatin 0-6 natriuretic peptides A Oryctolagus cuniculus 35-38 21863743-4 2011 The inhibitory effects of ODC (a heme-dependent inhibitor of sGC) and isatin were non-additive suggesting that the inhibitory effect of isatin may involve the heme binding domain (possibly heme iron) and experiments with hemin revealed some isatin-dependent changes in its spectrum. Isatin 136-142 ornithine decarboxylase 1 Homo sapiens 26-29 21863743-4 2011 The inhibitory effects of ODC (a heme-dependent inhibitor of sGC) and isatin were non-additive suggesting that the inhibitory effect of isatin may involve the heme binding domain (possibly heme iron) and experiments with hemin revealed some isatin-dependent changes in its spectrum. Isatin 136-142 ornithine decarboxylase 1 Homo sapiens 26-29 21863743-5 2011 Isatin also inhibited sGC activation by the allosteric activator YC-1. Isatin 0-6 sarcoglycan beta Homo sapiens 22-25 21863743-5 2011 Isatin also inhibited sGC activation by the allosteric activator YC-1. Isatin 0-6 RNA binding motif single stranded interacting protein 1 Homo sapiens 65-69 21863743-6 2011 It is suggested that the bell shaped inhibition of the NO-dependent activation of sGC by isatin may be attributed to complex interaction of isatin with the heme binding domain and the allosteric YC-1-binding site of sGC. Isatin 89-95 sarcoglycan beta Homo sapiens 82-85 21863743-6 2011 It is suggested that the bell shaped inhibition of the NO-dependent activation of sGC by isatin may be attributed to complex interaction of isatin with the heme binding domain and the allosteric YC-1-binding site of sGC. Isatin 89-95 RNA binding motif single stranded interacting protein 1 Homo sapiens 195-199 21863743-6 2011 It is suggested that the bell shaped inhibition of the NO-dependent activation of sGC by isatin may be attributed to complex interaction of isatin with the heme binding domain and the allosteric YC-1-binding site of sGC. Isatin 89-95 sarcoglycan beta Homo sapiens 216-219 21863743-6 2011 It is suggested that the bell shaped inhibition of the NO-dependent activation of sGC by isatin may be attributed to complex interaction of isatin with the heme binding domain and the allosteric YC-1-binding site of sGC. Isatin 140-146 sarcoglycan beta Homo sapiens 82-85 21441025-0 2011 Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay. Isatin 28-34 caspase 3 Homo sapiens 46-55 21441025-1 2011 A series of isatin analogs containing a hydrophilic group, including a pyridine ring, ethylene glycol group, and a triazole ring, have been synthesized, and their inhibition potency for caspase-3 was measured both in vitro (i.e., recombinant enzyme) and in whole cells (HeLa cells). Isatin 12-18 caspase 3 Homo sapiens 186-195 19342233-5 2009 Molecular docking studies with MAO-B indicate that the increased binding affinity exhibited by the (E)-styrylisatin analogues, in comparison to isatin, is best explained by the ability of the styrylisatins to bridge both the entrance cavity and the substrate cavity of the enzyme. Isatin 109-115 monoamine oxidase B Homo sapiens 31-36 21134756-5 2011 The C5-substituted isatins exhibited higher binding affinities to MAO-B than the corresponding C6-substituted homologues. Isatin 19-26 monoamine oxidase B Homo sapiens 66-71 21134756-6 2011 The most potent MAO-B inhibitor, 5-(4-phenylbutyl)isatin, exhibited an IC(50) value of 0.66nM, approximately 13-fold more potent than (E)-5-styrylisatin and 18,500-fold more potent than isatin. Isatin 50-56 monoamine oxidase B Homo sapiens 16-21 21134756-8 2011 The results document that substitution at C5 with a variety of substituents is a general strategy for enhancing the MAO-B inhibition potency of isatin. Isatin 144-150 monoamine oxidase B Homo sapiens 116-121 21134756-9 2011 Possible binding orientations of selected isatin analogues within the active site cavities of MAO-A and MAO-B are proposed. Isatin 42-48 monoamine oxidase A Homo sapiens 94-99 21134756-9 2011 Possible binding orientations of selected isatin analogues within the active site cavities of MAO-A and MAO-B are proposed. Isatin 42-48 monoamine oxidase B Homo sapiens 104-109 21328918-4 2010 In both cases cytokeratin binding with the immobilized isatin analogues was characterized by rather high affinity (Kd of 0.7 microM for the pair CK14/immobilized 5-aminocaproylisatin and 1.7 microM for the pair CK8/immobilized 5-aminoisatin). Isatin 55-61 keratin 14 Homo sapiens 145-149 21328918-4 2010 In both cases cytokeratin binding with the immobilized isatin analogues was characterized by rather high affinity (Kd of 0.7 microM for the pair CK14/immobilized 5-aminocaproylisatin and 1.7 microM for the pair CK8/immobilized 5-aminoisatin). Isatin 55-61 keratin 8 Homo sapiens 211-214 19910509-7 2009 Isatin, a specific ANP receptor antagonist, reversed ANP"s effect. Isatin 0-6 natriuretic peptide A Homo sapiens 19-22 19910509-7 2009 Isatin, a specific ANP receptor antagonist, reversed ANP"s effect. Isatin 0-6 natriuretic peptide A Homo sapiens 53-56 19841672-5 2009 Screening of a focused xenobiotic compound library revealed that CBR3 has narrower substrate specificity and acts on several orthoquinones, as well as isatin or the anticancer drug oracin. Isatin 151-157 carbonyl reductase 3 Homo sapiens 65-69 19651509-0 2009 Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors. Isatin 0-6 transthyretin Homo sapiens 37-50 19651509-1 2009 The isatin core structure was found to be a novel chemical scaffold in transthyretin (TTR) fibrillogenesis inhibitor design. Isatin 4-10 transthyretin Homo sapiens 71-84 19651509-1 2009 The isatin core structure was found to be a novel chemical scaffold in transthyretin (TTR) fibrillogenesis inhibitor design. Isatin 4-10 transthyretin Homo sapiens 86-89 19647171-2 2009 Radiolabeled isatins bind to caspase-3 with high affinity and are potential tracers for use with positron emission tomography to image apoptosis. Isatin 13-20 caspase 3 Rattus norvegicus 29-38 19647171-3 2009 We compared the ability of two novel radiolabeled isatins, [18F]WC-IV-3 and [11C]WC-98, to detect caspase-3 activation in a rat model of cycloheximide-induced liver injury. Isatin 50-57 caspase 3 Rattus norvegicus 98-107 19453193-2 2009 First, enantioselective arylation and alkenylation reactions of isatins using aryltrimethoxysilanes and alkenyltrimethoxysilanes as nucleophiles can be catalyzed by a complex of CuF with structurally tuned Taniaphos (6) in the presence of a catalytic amount of ZnF(2). Isatin 64-71 zinc finger protein 2 Homo sapiens 261-267 20651027-7 2010 Both relaxation and cGMP accumulation after uroguanylin stimulation were blocked by the putative particulate guanylyl cyclase type C inhibitors 2-chloro-ATP and isatin (1H-indole-2,3-dione), but not by the soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-A]quinoxalin-1-one (ODQ). Isatin 161-167 guanylate cyclase activator 2B Homo sapiens 44-55 20651027-7 2010 Both relaxation and cGMP accumulation after uroguanylin stimulation were blocked by the putative particulate guanylyl cyclase type C inhibitors 2-chloro-ATP and isatin (1H-indole-2,3-dione), but not by the soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-A]quinoxalin-1-one (ODQ). Isatin 169-188 guanylate cyclase activator 2B Homo sapiens 44-55 19900583-1 2010 Isatin, an endogenous indole compound, prevents atrial natriuretic peptide (ANP) from signaling through its cell-surface receptor, NPRA. Isatin 0-6 natriuretic peptide receptor 1 Mus musculus 131-135 19900583-4 2010 Isatin nanocapsules reduced lung pathology by blocking ANP signaling, but surprisingly also by reducing the expression of NPRA. Isatin 0-6 natriuretic peptide receptor 1 Mus musculus 122-126 19900583-5 2010 Ovalbumin-allergic mice were treated intranasally with isatin-containing chitosan nanocapsules either before or after allergen challenge, and lung function, cytokine levels, histopathology and cellular infiltration were determined. Isatin 55-61 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 0-9 19900583-8 2010 Isatin nanocapsules administered locally to the lung reduced cGMP production and NPRA expression and protected allergic mice from airway hyperreactivity and lung inflammation when given either before or after allergen challenge. Isatin 0-6 natriuretic peptide receptor 1 Mus musculus 81-85 19900583-10 2010 Isatin nanocapsules administered locally to the lung inhibit NPRA signaling but also are capable of lowering the expression of NPRA, thus effectively reducing inflammation in a mouse model of allergic asthma. Isatin 0-6 natriuretic peptide receptor 1 Mus musculus 61-65 19900583-10 2010 Isatin nanocapsules administered locally to the lung inhibit NPRA signaling but also are capable of lowering the expression of NPRA, thus effectively reducing inflammation in a mouse model of allergic asthma. Isatin 0-6 natriuretic peptide receptor 1 Mus musculus 127-131 19854048-1 2009 A novel series of isatin-based inhibitors of beta-secretase (BACE-1) have been identified using a virtual high-throughput screening approach. Isatin 18-24 beta-secretase 1 Homo sapiens 61-67 19397322-5 2009 The MDR1-selective pharmacophore highlights the importance of aromatic/hydrophobic features at the N4 position of the thiosemicarbazone and the reliance on the isatin moiety as key bioisosteric contributors. Isatin 160-166 ATP binding cassette subfamily B member 1 Homo sapiens 4-8 19300818-11 2009 Therefore, this study provides a useful method for radio-synthesis of isatin derivative radiotracers for PET and SPECT studies, and [11C] 4 is a potential PET radiotracer for noninvasive imaging of apoptosis. Isatin 70-76 thyroid stimulating hormone receptor Mus musculus 105-108 19049429-0 2008 Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide. Isatin 78-84 caspase 3 Homo sapiens 56-65 18951902-6 2008 A molecule of l-proline was observed near the FAD, and this ligand superimposed well with isatin, a reversible inhibitor of MAO-B, when the structures of MAO-N proline and MAO-B-isatin were overlaid. Isatin 90-96 monoamine oxidase B Homo sapiens 124-129 18951902-6 2008 A molecule of l-proline was observed near the FAD, and this ligand superimposed well with isatin, a reversible inhibitor of MAO-B, when the structures of MAO-N proline and MAO-B-isatin were overlaid. Isatin 90-96 monoamine oxidase B Homo sapiens 172-177 19061875-8 2009 Towards isatin, wild-type CBR3 showed a catalytic efficiency of 0.018 microM(-1)min(-1), whereas wild-type CBR1 showed a catalytic efficiency of 13.5 microM(-1)min(-1). Isatin 8-14 carbonyl reductase 3 Homo sapiens 26-30 19061875-8 2009 Towards isatin, wild-type CBR3 showed a catalytic efficiency of 0.018 microM(-1)min(-1), whereas wild-type CBR1 showed a catalytic efficiency of 13.5 microM(-1)min(-1). Isatin 8-14 carbonyl reductase 1 Homo sapiens 107-111 19061875-9 2009 In particular, when nine residues (236-244) in the vicinity of the catalytic center and a proline (P230) in CBR3 were mutated to the corresponding residues of CBR1 a much higher k(cat)/K(m) value (5.7 microM(-1)min(-1)) towards isatin was observed. Isatin 228-234 carbonyl reductase 3 Homo sapiens 108-112 19061875-9 2009 In particular, when nine residues (236-244) in the vicinity of the catalytic center and a proline (P230) in CBR3 were mutated to the corresponding residues of CBR1 a much higher k(cat)/K(m) value (5.7 microM(-1)min(-1)) towards isatin was observed. Isatin 228-234 carbonyl reductase 1 Homo sapiens 159-163 19115816-2 2009 Here, we describe a novel series of selective CB2 inverse agonists resulting from introduction of a methoxy moiety in position 6 of the isatin scaffold. Isatin 136-142 cannabinoid receptor 2 Homo sapiens 46-49 18561913-9 2008 Expression of phosphorylated ERKs decreased, but the level of activated caspase-3 increased after treatment of Isatin. Isatin 111-117 caspase 3 Homo sapiens 72-81 18680359-2 2008 A focused library incorporating an isatin scaffold was designed and evaluated for inhibition of Shp2 and Shp1 PTP activities. Isatin 35-41 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 96-100 18680359-2 2008 A focused library incorporating an isatin scaffold was designed and evaluated for inhibition of Shp2 and Shp1 PTP activities. Isatin 35-41 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 105-109 18680359-2 2008 A focused library incorporating an isatin scaffold was designed and evaluated for inhibition of Shp2 and Shp1 PTP activities. Isatin 35-41 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 110-113 17649976-4 2007 In this article, we report the results of inhibition kinetics and binding studies utilizing fluorescence spectroscopy and isothermal titration calorimetry to characterize the mechanism of interaction of caspase-3 with three different classes of inhibitors: peptidomimetics, isatins, and pyrimidoindolones. Isatin 274-281 caspase 3 Homo sapiens 203-212 18988463-2 2008 Physiological concentrations of isatin inhibit natriuretic peptide (NPR) receptor binding and NPR-dependent signalling. Isatin 32-38 neuronal pentraxin receptor Rattus norvegicus 68-71 18988463-2 2008 Physiological concentrations of isatin inhibit natriuretic peptide (NPR) receptor binding and NPR-dependent signalling. Isatin 32-38 neuronal pentraxin receptor Rattus norvegicus 94-97 18988463-3 2008 The inhibition of NPR signalling by isatin is attenuated by a nonhydrolyzable ATP analogue. Isatin 36-42 neuronal pentraxin receptor Rattus norvegicus 18-21 18334118-6 2008 Along with the increase of ISA concentration, Bcl-2 expression was decreased, the ratio of Bcl-2 to Bax was significantly decreased (P<0.05). Isatin 27-30 BCL2 apoptosis regulator Homo sapiens 46-51 18334118-6 2008 Along with the increase of ISA concentration, Bcl-2 expression was decreased, the ratio of Bcl-2 to Bax was significantly decreased (P<0.05). Isatin 27-30 BCL2 apoptosis regulator Homo sapiens 91-96 18334118-6 2008 Along with the increase of ISA concentration, Bcl-2 expression was decreased, the ratio of Bcl-2 to Bax was significantly decreased (P<0.05). Isatin 27-30 BCL2 associated X, apoptosis regulator Homo sapiens 100-103 18334118-7 2008 When treated with ISA (100, 200, 400 micromol/L) for 48 h, the positive rates of activated Caspase-3 in SH-SY5Y cells were significantly higher than that in control SH-SY5Y cells (19.28%, 25.88%, and 33.43% vs. 10.58%, P<0.05). Isatin 18-21 caspase 3 Homo sapiens 91-100 18334118-9 2008 In addition, the proportion of SH-SY5Y cells at G1 phase was significantly increased with an apparent G1 phase arrest when treated with ISA (100, 200, 400 micromol/L) for 48 h. In the progress of cell cycle arrest induced by ISA, phosphorylated ERK and CDK1 expression were down-regulated (P<0.05). Isatin 136-139 mitogen-activated protein kinase 1 Homo sapiens 245-248 18334118-9 2008 In addition, the proportion of SH-SY5Y cells at G1 phase was significantly increased with an apparent G1 phase arrest when treated with ISA (100, 200, 400 micromol/L) for 48 h. In the progress of cell cycle arrest induced by ISA, phosphorylated ERK and CDK1 expression were down-regulated (P<0.05). Isatin 136-139 cyclin dependent kinase 1 Homo sapiens 253-257 18334118-9 2008 In addition, the proportion of SH-SY5Y cells at G1 phase was significantly increased with an apparent G1 phase arrest when treated with ISA (100, 200, 400 micromol/L) for 48 h. In the progress of cell cycle arrest induced by ISA, phosphorylated ERK and CDK1 expression were down-regulated (P<0.05). Isatin 225-228 mitogen-activated protein kinase 1 Homo sapiens 245-248 18334118-9 2008 In addition, the proportion of SH-SY5Y cells at G1 phase was significantly increased with an apparent G1 phase arrest when treated with ISA (100, 200, 400 micromol/L) for 48 h. In the progress of cell cycle arrest induced by ISA, phosphorylated ERK and CDK1 expression were down-regulated (P<0.05). Isatin 225-228 cyclin dependent kinase 1 Homo sapiens 253-257 17761421-2 2007 A previous study of high-throughput drug screening identified an isatin derivative as a UCH-L3 inhibitor. Isatin 65-71 ubiquitin C-terminal hydrolase L3 Homo sapiens 88-94 17649976-7 2007 In contrast, the isatins bind to caspase-3 with significant heat release (-12 kcal/mol) and negative entropy. Isatin 17-24 caspase 3 Homo sapiens 33-42 17141756-0 2007 Isatins inhibit cyclooxygenase-2 and inducible nitric oxide synthase in a mouse macrophage cell line. Isatin 0-7 prostaglandin-endoperoxide synthase 2 Mus musculus 16-68 17141756-2 2007 We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO. Isatin 52-58 interferon gamma Mus musculus 93-109 17141756-2 2007 We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO. Isatin 52-58 nitric oxide synthase 2, inducible Mus musculus 132-163 17141756-2 2007 We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO. Isatin 52-58 nitric oxide synthase 2, inducible Mus musculus 165-169 17141756-2 2007 We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO. Isatin 52-58 prostaglandin-endoperoxide synthase 2 Mus musculus 175-191 17141756-2 2007 We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO. Isatin 52-58 prostaglandin-endoperoxide synthase 2 Mus musculus 193-198 17141756-2 2007 We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO. Isatin 52-58 tumor necrosis factor Mus musculus 272-293 17141756-2 2007 We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO. Isatin 52-58 tumor necrosis factor Mus musculus 295-304 17141756-3 2007 Isatins inhibit TNF-alpha production and iNOS and COX-2 protein expression resulting on reduced levels of NO and PGE(2). Isatin 0-7 tumor necrosis factor Mus musculus 16-25 17141756-3 2007 Isatins inhibit TNF-alpha production and iNOS and COX-2 protein expression resulting on reduced levels of NO and PGE(2). Isatin 0-7 nitric oxide synthase 2, inducible Mus musculus 41-45 17141756-3 2007 Isatins inhibit TNF-alpha production and iNOS and COX-2 protein expression resulting on reduced levels of NO and PGE(2). Isatin 0-7 prostaglandin-endoperoxide synthase 2 Mus musculus 50-55 17141756-4 2007 Our results indicate isatin and it derivatives as inhibitors of iNOS and COX-2 enzymes, which might be used as anti-inflammatory and antitumoral agents. Isatin 21-27 nitric oxide synthase 2, inducible Mus musculus 64-68 17141756-4 2007 Our results indicate isatin and it derivatives as inhibitors of iNOS and COX-2 enzymes, which might be used as anti-inflammatory and antitumoral agents. Isatin 21-27 prostaglandin-endoperoxide synthase 2 Mus musculus 73-78 15710600-3 2005 In contrast, the reversible competitive inhibitor isatin binds to all known MAO B and MAO A with similar affinities. Isatin 50-56 monoamine oxidase B Homo sapiens 76-81 16891117-0 2006 Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis. Isatin 67-73 caspase 3 Rattus norvegicus 93-102 15854583-2 2005 In the present study, we have demonstrated that atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) inhibited [3H]isatin binding to rat brain sections and isolated membrane fractions. Isatin 132-138 natriuretic peptide A Rattus norvegicus 48-74 15854583-2 2005 In the present study, we have demonstrated that atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) inhibited [3H]isatin binding to rat brain sections and isolated membrane fractions. Isatin 132-138 natriuretic peptide C Rattus norvegicus 85-111 15854583-2 2005 In the present study, we have demonstrated that atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) inhibited [3H]isatin binding to rat brain sections and isolated membrane fractions. Isatin 132-138 natriuretic peptide C Rattus norvegicus 113-116 15854583-3 2005 Isatin itself antagonised not only natriuretic peptide receptor type A (NPR-A) (ANP-stimulation of guanylyl cyclase) but also NPR-C (ANP and CNP mediated inhibition of adenylyl cyclase) signalling. Isatin 0-6 natriuretic peptide receptor 1 Rattus norvegicus 35-70 15854583-3 2005 Isatin itself antagonised not only natriuretic peptide receptor type A (NPR-A) (ANP-stimulation of guanylyl cyclase) but also NPR-C (ANP and CNP mediated inhibition of adenylyl cyclase) signalling. Isatin 0-6 natriuretic peptide receptor 1 Rattus norvegicus 72-77 15854583-3 2005 Isatin itself antagonised not only natriuretic peptide receptor type A (NPR-A) (ANP-stimulation of guanylyl cyclase) but also NPR-C (ANP and CNP mediated inhibition of adenylyl cyclase) signalling. Isatin 0-6 natriuretic peptide receptor 3 Rattus norvegicus 126-131 15854583-3 2005 Isatin itself antagonised not only natriuretic peptide receptor type A (NPR-A) (ANP-stimulation of guanylyl cyclase) but also NPR-C (ANP and CNP mediated inhibition of adenylyl cyclase) signalling. Isatin 0-6 natriuretic peptide C Rattus norvegicus 141-144 15854583-4 2005 These results suggest that some [3H]isatin binding in the brain may be to NPR-A and NPR-C. Isatin 36-42 natriuretic peptide receptor 1 Rattus norvegicus 74-79 15854583-4 2005 These results suggest that some [3H]isatin binding in the brain may be to NPR-A and NPR-C. Isatin 36-42 natriuretic peptide receptor 3 Rattus norvegicus 84-89 15854583-5 2005 Competitive interactions between isatin and natriuretic peptides and their receptors give a possible explanation of the known anxiogenic effect of low doses of isatin, interacting at NPR-A, and the sedative effects of higher doses, antagonising respectively the anxiolytic effect of ANP and the anxiogenic effect of CNP. Isatin 33-39 natriuretic peptide receptor 1 Rattus norvegicus 183-188 15854583-5 2005 Competitive interactions between isatin and natriuretic peptides and their receptors give a possible explanation of the known anxiogenic effect of low doses of isatin, interacting at NPR-A, and the sedative effects of higher doses, antagonising respectively the anxiolytic effect of ANP and the anxiogenic effect of CNP. Isatin 33-39 natriuretic peptide C Rattus norvegicus 316-319 15854583-5 2005 Competitive interactions between isatin and natriuretic peptides and their receptors give a possible explanation of the known anxiogenic effect of low doses of isatin, interacting at NPR-A, and the sedative effects of higher doses, antagonising respectively the anxiolytic effect of ANP and the anxiogenic effect of CNP. Isatin 160-166 natriuretic peptide receptor 1 Rattus norvegicus 183-188 15854583-5 2005 Competitive interactions between isatin and natriuretic peptides and their receptors give a possible explanation of the known anxiogenic effect of low doses of isatin, interacting at NPR-A, and the sedative effects of higher doses, antagonising respectively the anxiolytic effect of ANP and the anxiogenic effect of CNP. Isatin 160-166 natriuretic peptide C Rattus norvegicus 316-319 15876476-1 2005 Isatin is an endogenous indole that is increased in stress, inhibits monoamine oxidase (MAO) B and improves bradykinesia and striatal dopamine levels in rat models of Parkinson"s disease. Isatin 0-6 monoamine oxidase B Rattus norvegicus 69-94 15930748-7 2005 Thus, AKR1C19 possesses properties distinct from other members of the AKR superfamily, and may function as a reductase for endogenous isatin and xenobiotic alpha-dicarbonyl compounds in the liver and gastrointestinal tract. Isatin 134-140 aldo-keto reductase family 1, member C19 Mus musculus 6-13 15710600-3 2005 In contrast, the reversible competitive inhibitor isatin binds to all known MAO B and MAO A with similar affinities. Isatin 50-56 monoamine oxidase A Homo sapiens 86-91 15710600-8 2005 The human MAO B I199F mutant protein of MAO B binds to isatin (K(i) = 3 microM) but not to the three inhibitors listed above. Isatin 55-61 monoamine oxidase B Homo sapiens 10-15 15710600-8 2005 The human MAO B I199F mutant protein of MAO B binds to isatin (K(i) = 3 microM) but not to the three inhibitors listed above. Isatin 55-61 monoamine oxidase B Homo sapiens 40-45 15276478-7 2004 The effect of hANP was completely blocked by isatin, a potent antagonist of NPR (p < 0.01 vs. hANP). Isatin 45-51 natriuretic peptide A Homo sapiens 14-18 17191919-3 2005 In this work, a new disubstituted indigoid generation system was developed with a tryptophanase-deficient Escherichia coli strain as a host to express the human cytochrome P450 2A6 mutant L240C/N297Q, which catalyzes the oxidation of indole to isatin and indoxyl, which in turn react to generate indigoids. Isatin 244-250 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 161-180 15628602-0 2004 [The effect of long-term administration of isatin and himantan to mice on sensitivity of brain monoamine oxidase B to inhibition by deprenyl in vivo and in vitro]. Isatin 43-49 monoamine oxidase B Mus musculus 95-114 15628602-6 2004 In vitro inhibition of MAO B activity in mitochondria isolated from brain of mice treated with isatin or himantane was somewhat higher than in control mitochondria. Isatin 95-101 monoamine oxidase B Mus musculus 23-28 15276478-7 2004 The effect of hANP was completely blocked by isatin, a potent antagonist of NPR (p < 0.01 vs. hANP). Isatin 45-51 neuronal pentraxin receptor Homo sapiens 76-79 15276478-7 2004 The effect of hANP was completely blocked by isatin, a potent antagonist of NPR (p < 0.01 vs. hANP). Isatin 45-51 natriuretic peptide A Homo sapiens 97-101 11895568-3 2002 In this study the aim was to investigate the effects of isatin on thermoregulatory actions of PACAP-38, in rats. Isatin 56-62 adenylate cyclase activating polypeptide 1 Rattus norvegicus 94-99 15279562-4 2004 The recent development of high level expression systems for producing recombinant human liver MAO A and MAO B in Pichia pastoris has facilitated the determination of the three dimensional crystal structures of MAO B (up to 1.7 angstroms resolution) in complex with different reversible (isatin, 1,4-diphenyl-2-butene) and irreversible inhibitors (pargyline, N-(2-aminoethyl)-p-chlorobenzamide, and trans-2-phenylcyclopropylamine). Isatin 287-293 monoamine oxidase B Homo sapiens 210-215 15104251-2 2004 Its physiological role remains unclear but certain evidence exists, that it may share some regulatory properties with isatin, a known endogenous inhibitor of monoamine oxidase (MAO) type B (MAO-B). Isatin 118-124 monoamine oxidase B Rattus norvegicus 158-188 15104251-2 2004 Its physiological role remains unclear but certain evidence exists, that it may share some regulatory properties with isatin, a known endogenous inhibitor of monoamine oxidase (MAO) type B (MAO-B). Isatin 118-124 monoamine oxidase B Rattus norvegicus 190-195 14697895-1 2004 We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. Isatin 53-59 monoamine oxidase A Rattus norvegicus 75-92 14697895-1 2004 We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. Isatin 53-59 monoamine oxidase A Rattus norvegicus 94-97 12189628-3 2002 Isatin acted as a rather selective monoamine oxidase B inhibitor, whereas 5-hydroxyoxindole was more selective monoamine oxidase A inhibitor, but it was less potent than that of 5-hydroxyisatin, a synthetic analogue of isatin. Isatin 0-6 monoamine oxidase B Rattus norvegicus 35-54 12480089-0 2003 Isatin, an endogenous MAO inhibitor, improves bradykinesia and dopamine levels in a rat model of Parkinson"s disease induced by Japanese encephalitis virus. Isatin 0-6 monoamine oxidase A Rattus norvegicus 22-25 12480089-1 2003 Isatin, an endogenous monoamine oxidase (MAO) inhibitor, has an important role in the control of neurotransmitter concentration. Isatin 0-6 monoamine oxidase A Rattus norvegicus 41-44 11895568-7 2002 injection of different doses of isatin (25-50 mg/kg) significantly decreased the hyperthermic effect of 1 microg PACAP-38 (icv. Isatin 32-38 adenylate cyclase activating polypeptide 1 Rattus norvegicus 113-118 11895568-11 2002 CONCLUSION: The mechanisms that participate in the mediation of the PACAP-38-induced hyperthermia may be modified by isatin. Isatin 117-123 adenylate cyclase activating polypeptide 1 Rattus norvegicus 68-73 11895568-12 2002 The capability of isatin to antagonize the hyperthermia induced by all members of the natriuretic peptide family and by PACAP-38 makes it unlikely to be acting directly on receptors for natriuretic peptides or on those for PACAP in these hyperthermic processes. Isatin 18-24 adenylate cyclase activating polypeptide 1 Rattus norvegicus 120-125 11602237-1 2001 Isatin was a potent endogenous monoamine oxidase (MAO) inhibitor that is more active against MAO-B than MAO-A. Isatin 0-6 monoamine oxidase A Rattus norvegicus 31-48 11602237-1 2001 Isatin was a potent endogenous monoamine oxidase (MAO) inhibitor that is more active against MAO-B than MAO-A. Isatin 0-6 monoamine oxidase A Rattus norvegicus 50-53 11602237-1 2001 Isatin was a potent endogenous monoamine oxidase (MAO) inhibitor that is more active against MAO-B than MAO-A. Isatin 0-6 monoamine oxidase B Rattus norvegicus 93-98 11602237-1 2001 Isatin was a potent endogenous monoamine oxidase (MAO) inhibitor that is more active against MAO-B than MAO-A. Isatin 0-6 monoamine oxidase A Rattus norvegicus 104-109 11389882-0 2001 Cyclic GMP excretion blocked by isatin administration under conditions of fluid overload. Isatin 32-38 5'-nucleotidase, cytosolic II Homo sapiens 7-10 11665840-0 2001 Effects of isatin on atrial natriuretic peptide-mediated accumulation of cGMP and guanylyl cyclase activity of PC12 cells. Isatin 11-17 natriuretic peptide A Rattus norvegicus 21-47 11665840-1 2001 We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations. Isatin 37-43 natriuretic peptide A Rattus norvegicus 165-191 11665840-1 2001 We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations. Isatin 37-43 natriuretic peptide A Rattus norvegicus 193-196 11665840-1 2001 We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations. Isatin 37-43 natriuretic peptide A Rattus norvegicus 219-222 11665840-1 2001 We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations. Isatin 45-61 natriuretic peptide A Rattus norvegicus 165-191 11665840-1 2001 We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations. Isatin 45-61 natriuretic peptide A Rattus norvegicus 193-196 11665840-1 2001 We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations. Isatin 45-61 natriuretic peptide A Rattus norvegicus 219-222 11665840-2 2001 In the present study the effects of isatin on ANP-mediated accumulation of cGMP and guanylyl cyclase (GC) activity of PC12 cells were studied. Isatin 36-42 natriuretic peptide A Rattus norvegicus 46-49 11665840-3 2001 Isatin (0.1 mM) effectively inhibited ANP-stimulated GC-activity of broken cells but was nearly inactive in attenuating ANP-dependent accumulation of cGMP in intact PC12 cells. Isatin 0-6 natriuretic peptide A Rattus norvegicus 38-41 11665840-5 2001 Isatin caused a more pronounced reduction of ANP-dependent cGMP accumulation in cells grown in the presence of 10% embryonal calf serum (ECS) than in 0.5% ECS. Isatin 0-6 natriuretic peptide A Rattus norvegicus 45-48 11665840-6 2001 The data obtained suggest that, in intact cells, the manifestation of the isatin effect on ANP-mediated signal transduction may depend on intracellular factor(s), possibly interacting at the kinase domain. Isatin 74-80 natriuretic peptide A Rattus norvegicus 91-94 11253400-3 2001 50 microM isatin it increased the amplitude of the population spike in the CA1 evoked by stimulation of stratum radiatum. Isatin 10-16 carbonic anhydrase 1 Rattus norvegicus 75-78 11086715-0 2000 Parallel synthesis of isatin-based serine protease inhibitors. Isatin 22-28 coagulation factor II, thrombin Homo sapiens 35-50 11113594-0 2000 The action of isatin (2,3-dioxoindole) an endogenous indole on brain natriuretic and C-type natriuretic peptide-induced facilitation of memory consolidation in passive-avoidance learning in rats. Isatin 14-20 natriuretic peptide C Rattus norvegicus 85-111 11113594-1 2000 Isatin is an endogenous indole which has been shown to counteract some of the effects of atrial natriuretic peptide (ANP) both in vitro and in vivo. Isatin 0-6 natriuretic peptide A Rattus norvegicus 89-115 11113594-8 2000 Isatin reduced the effect of both BNP and CNP; this was significant for its effect on BNP at 50 mg/kg and on CNP at both 10 and 50 mg/kg. Isatin 0-6 natriuretic peptide B Rattus norvegicus 34-37 11113594-8 2000 Isatin reduced the effect of both BNP and CNP; this was significant for its effect on BNP at 50 mg/kg and on CNP at both 10 and 50 mg/kg. Isatin 0-6 natriuretic peptide C Rattus norvegicus 42-45 11113594-8 2000 Isatin reduced the effect of both BNP and CNP; this was significant for its effect on BNP at 50 mg/kg and on CNP at both 10 and 50 mg/kg. Isatin 0-6 natriuretic peptide B Rattus norvegicus 86-89 11113594-8 2000 Isatin reduced the effect of both BNP and CNP; this was significant for its effect on BNP at 50 mg/kg and on CNP at both 10 and 50 mg/kg. Isatin 0-6 natriuretic peptide C Rattus norvegicus 109-112 11113594-9 2000 These results show that isatin can inhibit behavioural effects of BNP and CNP as well as ANP. Isatin 24-30 natriuretic peptide B Rattus norvegicus 66-69 11113594-9 2000 These results show that isatin can inhibit behavioural effects of BNP and CNP as well as ANP. Isatin 24-30 natriuretic peptide C Rattus norvegicus 74-77 10774257-0 2000 [Pharmacological role of isatin, an endogenous MAO inhibitor]. Isatin 25-31 monoamine oxidase A Rattus norvegicus 47-50 11006132-4 2000 Acute treatment with 5-hydroxyoxindole and isatin reduced the activity of extracellular signal regulated protein kinases (ERKs) by 35% at 100 microM and ERK1 activity was strongly inhibited by 5-Hydroxyoxindole at 10 microM. Isatin 43-49 mitogen-activated protein kinase 3 Homo sapiens 122-126 11006132-4 2000 Acute treatment with 5-hydroxyoxindole and isatin reduced the activity of extracellular signal regulated protein kinases (ERKs) by 35% at 100 microM and ERK1 activity was strongly inhibited by 5-Hydroxyoxindole at 10 microM. Isatin 43-49 mitogen-activated protein kinase 3 Homo sapiens 153-157 10978188-5 2000 In general, indoles, indazoles, benzotriazoles, indolones, and isatins gave analogues with weaker NR1A/2B activity than the parent phenols, while benzimidazolones and benzimidazolinones gave equipotent or more potent analogues. Isatin 63-70 thyroid hormone receptor beta Homo sapiens 98-104 10774257-2 2000 I previously identified isatin as an endogenous inhibitor of monoamine oxidase (MAO) in the human urine and the brain of stroke-prone spontaneously hypertensive rats (SHRSP) using GC-MS. A single dose of isatin significantly increased norepinephrine (NE) and 5-hydroxytryptamine (5-HT) concentrations measured 2 h later in the various brain regions of normotensive Wistar Kyoto rats (WKY). Isatin 24-30 monoamine oxidase A Rattus norvegicus 80-83 10629878-0 1999 [Effects of isatin, an endogenous MAO inhibitor, on dopamine (DA) and acetylcholine (ACh) concentrations in rats]. Isatin 12-18 monoamine oxidase A Rattus norvegicus 34-37 11061215-3 2000 Among various isatin analogues with nearllanar structure selective MAO B inhibitors fit to 3D box of 8.5x5.1x1.8 A, whereas 3D box of 14.2x5.6x1.8 A accommodates selective MAO A inhibitors. Isatin 14-20 monoamine oxidase B Homo sapiens 67-72 11061215-3 2000 Among various isatin analogues with nearllanar structure selective MAO B inhibitors fit to 3D box of 8.5x5.1x1.8 A, whereas 3D box of 14.2x5.6x1.8 A accommodates selective MAO A inhibitors. Isatin 14-20 monoamine oxidase A Homo sapiens 172-177 11061215-7 2000 3D-QSAR with CoMFA of isatin and pirlindole analogues of MAO A and B revealed differences in the models of MAO A and B. Isatin 22-28 monoamine oxidase A Homo sapiens 57-62 10510318-4 1999 Also, AKR7A2 was found to exhibit a narrow substrate specificity, with activity being restricted to succinic semialdehyde (SSA), 2-nitrobenzaldehyde, pyridine-2-aldehyde, isatin, 1,2-naphthoquinone (1,2-NQ) and 9,10-phenanthrenequinone. Isatin 171-177 aldo-keto reductase family 7 member A2 Homo sapiens 6-12 10629878-1 1999 Isatin (indole-2,3-dione), an endogenous inhibitor of monoamine oxidase (MAO), has several physiological properties for stress and anxiety. Isatin 0-6 monoamine oxidase A Rattus norvegicus 54-71 10629878-1 1999 Isatin (indole-2,3-dione), an endogenous inhibitor of monoamine oxidase (MAO), has several physiological properties for stress and anxiety. Isatin 0-6 monoamine oxidase A Rattus norvegicus 73-76 10629878-1 1999 Isatin (indole-2,3-dione), an endogenous inhibitor of monoamine oxidase (MAO), has several physiological properties for stress and anxiety. Isatin 8-24 monoamine oxidase A Rattus norvegicus 54-71 10629878-1 1999 Isatin (indole-2,3-dione), an endogenous inhibitor of monoamine oxidase (MAO), has several physiological properties for stress and anxiety. Isatin 8-24 monoamine oxidase A Rattus norvegicus 73-76 10093500-7 1998 Isatin is an endogenous anxiogenic factor which is also a potent inhibitor of the ANP receptor. Isatin 0-6 natriuretic peptide A Homo sapiens 82-85 9776316-5 1998 Furthermore, administration of either the benzodiazepine receptor agonist diazepam or the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine prevented the increase in urinary isatin excretion induced by acute food deprivation, whereas the dopamine-beta-hydroxylase inhibitor diethyldithiocarbamate proved ineffective. Isatin 179-185 dopamine beta-hydroxylase Rattus norvegicus 243-268 9324239-3 1997 In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg). Isatin 27-33 monoamine oxidase A Rattus norvegicus 201-206 9510091-0 1998 Determination of isatin, an endogenous monoamine oxidase inhibitor, in urine and tissues of rats by HPLC. Isatin 17-23 monoamine oxidase A Rattus norvegicus 39-56 9510091-2 1998 We have previously identified isatin as one of the endogenous monoamine oxidase (MAO) inhibitors in the urine and the brain of stroke-prone spontaneously hypertensive rats (SHRSP), using gas chromatography-mass spectrometry (GC-MS). Isatin 30-36 monoamine oxidase A Rattus norvegicus 62-79 9510091-2 1998 We have previously identified isatin as one of the endogenous monoamine oxidase (MAO) inhibitors in the urine and the brain of stroke-prone spontaneously hypertensive rats (SHRSP), using gas chromatography-mass spectrometry (GC-MS). Isatin 30-36 monoamine oxidase A Rattus norvegicus 81-84 9510091-9 1998 Isatin concentration correlated significantly and positively with endogenous MAO activity (tribulin-like activity) in both urine (r=0.924, P<0.001) and kidney extracts (r=0.862, P<0.01). Isatin 0-6 monoamine oxidase A Rattus norvegicus 77-80 9503568-4 1997 In vitro, isatin selectively inhibits monoamine oxidase (MAO) B (IC50 3-8 microM, Ki approximately 20 microM) and, more potently, atrial natriuretic peptide(ANP) binding (IC50, 0.4 microM). Isatin 10-16 monoamine oxidase B Homo sapiens 38-63 9536661-12 1998 The proconvulsant effect of isatin, may be due to its inhibitory effect on central atrial natriuretic peptide receptors and stimulation of 5-hydroxytryptamine3 (5-HT3) rather than its monoamine oxidase (MAO) B inhibitory action. Isatin 28-34 monoamine oxidase B Rattus norvegicus 184-209 9564631-9 1998 Isatin is an endogenous selective inhibitor of MAO-B (K1 approximately 3 microM). Isatin 0-6 monoamine oxidase B Homo sapiens 47-52 9651105-6 1998 These results suggest that isatin antagonises the generation of second messenger by GC-A; this sensitivity might be regulated at an ATP binding site, possibly a protein kinase-like domain. Isatin 27-33 grancalcin Rattus norvegicus 84-88 9324239-1 1997 Isatin is a reversible endogenous monoamine oxidase (MAO) inhibitor found in the brain. Isatin 0-6 monoamine oxidase A Rattus norvegicus 34-51 9324239-1 1997 Isatin is a reversible endogenous monoamine oxidase (MAO) inhibitor found in the brain. Isatin 0-6 monoamine oxidase A Rattus norvegicus 53-56 9324239-2 1997 The influence of isatin on the degree of irreversible MAO inhibition by phenelzine and pargyline has been studied in vitro and in vivo experiments. Isatin 17-23 monoamine oxidase A Rattus norvegicus 54-57 9324239-3 1997 In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg). Isatin 27-33 monoamine oxidase A Rattus norvegicus 69-74 9324239-3 1997 In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg). Isatin 27-33 monoamine oxidase B Rattus norvegicus 79-84 9324239-3 1997 In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg). Isatin 27-33 monoamine oxidase B Rattus norvegicus 211-216 9324239-3 1997 In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg). Isatin 165-171 monoamine oxidase A Rattus norvegicus 69-74 9324239-3 1997 In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg). Isatin 165-171 monoamine oxidase B Rattus norvegicus 79-84 9324239-3 1997 In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg). Isatin 165-171 monoamine oxidase A Rattus norvegicus 201-206 9324239-3 1997 In vitro 10 and 100 microM isatin reduced irreversible inhibition of MAO A and MAO B assayed after mitochondria wash. Pretreatment of rats with "anxiogenic dose" of isatin (10 mg/kg) protected neither MAO A nor MAO B against subsequently administered phenelzine (10 mg/kg). Isatin 165-171 monoamine oxidase B Rattus norvegicus 211-216 9324239-4 1997 "Anticonvulsant" dose of isatin (80 mg/kg) reduced phenelzine-dependent inhibition of MAO B but not MAO A. Isatin 25-31 monoamine oxidase B Rattus norvegicus 86-91 9324239-4 1997 "Anticonvulsant" dose of isatin (80 mg/kg) reduced phenelzine-dependent inhibition of MAO B but not MAO A. Isatin 25-31 monoamine oxidase A Rattus norvegicus 100-105 8840356-4 1996 Isatin, an endogenous anxiogenic indole, shown to be an antagonist of ANP in vitro, significantly inhibited the anxiolytic effect of ANP in the elevated plus-maze test in subanxiogenic doses. Isatin 0-6 natriuretic peptide A Rattus norvegicus 70-73 8840356-4 1996 Isatin, an endogenous anxiogenic indole, shown to be an antagonist of ANP in vitro, significantly inhibited the anxiolytic effect of ANP in the elevated plus-maze test in subanxiogenic doses. Isatin 0-6 natriuretic peptide A Rattus norvegicus 133-136 8840356-7 1996 The data indicate that ANP may function as an endogenous anxiomodulator, which may act in conjunction with isatin independently of benzodiazepine receptors. Isatin 107-113 natriuretic peptide A Rattus norvegicus 23-26 9072455-0 1995 Role of an endogenous monoamine oxidase inhibitor, isatin, in SHRSP brain. Isatin 51-57 monoamine oxidase A Rattus norvegicus 22-39 9148606-4 1996 Isatin is a selective inhibitor of monoamine oxidase B. Isatin 0-6 monoamine oxidase B Homo sapiens 35-54 8543325-2 1995 Earlier studies have indicated that isatin functions as a 5-hydroxytryptamine (5-HT)3 receptor agonist in its anxiogenic activity in rats and is an antagonist at mammalian atrial natriuretic peptide (ANP) receptors. Isatin 36-42 5-hydroxytryptamine receptor 3A Rattus norvegicus 79-94 9072455-11 1995 These data suggest that isatin, an endogenous MAO inhibitor, presents in the SHRSP brain and maintains high blood pressure. Isatin 24-30 monoamine oxidase A Rattus norvegicus 46-49 7663405-6 1995 The presence of hydroxy group at C5 of isatin increased selectivity of MAO-A inhibition, however simultaneous insertion of substituents into both positions of indole ring (5-hydroxy-2-phenylindole) led to a decrease of MAO-A inhibition. Isatin 39-45 monoamine oxidase A Homo sapiens 71-76 7663405-6 1995 The presence of hydroxy group at C5 of isatin increased selectivity of MAO-A inhibition, however simultaneous insertion of substituents into both positions of indole ring (5-hydroxy-2-phenylindole) led to a decrease of MAO-A inhibition. Isatin 39-45 monoamine oxidase A Homo sapiens 219-224 7786964-0 1995 CSF isatin is elevated in bulimia nervosa. Isatin 4-10 colony stimulating factor 2 Homo sapiens 0-3 1768136-5 1991 Isatin (indole-2,3-dione) was produced as an intermediate when the consortium was amended with oxindole, providing evidence that degradation of indole proceeded through successive hydroxylation of the 2- and 3-positions prior to ring cleavage between the C-2 and C-3 atoms on the pyrrole ring of indole. Isatin 0-6 complement C2 Homo sapiens 255-266 7753903-1 1995 Isatin is an endogenous selective inhibitor of monoamine oxidase (MAO) B, related to tribulin, whose activity and excretion in urine is increased during stress and anxiety. Isatin 0-6 monoamine oxidase B Rattus norvegicus 47-72 8527006-2 1995 We have previously identified one of them, isatin, which is a selective inhibitor of MAO B. Isatin 43-49 monoamine oxidase B Homo sapiens 85-90 1510706-0 1992 Inhibitory potency of some isatin analogues on human monoamine oxidase A and B. Isatin 27-33 monoamine oxidase A Homo sapiens 53-78 1510706-1 1992 Isatin is an endogenous compound which acts as a selective inhibitor of monoamine oxidase (MAO) B. Isatin 0-6 monoamine oxidase B Homo sapiens 72-97 1510706-2 1992 In this study a range of isatin analogues were tested for their in vitro inhibition of human MAO A and B. Isatin 25-31 monoamine oxidase A Homo sapiens 93-104 7475958-0 1995 Isatin is a potent endogenous antagonist of guanylate cyclase-coupled atrial natriuretic peptide receptors. Isatin 0-6 natriuretic peptide A Rattus norvegicus 70-96 7475958-3 1995 In the present study, we show that isatin has little effect on a wide range of neurotransmitter and hormonal receptors but that it acts as an inhibitor of atrial natriuretic peptide (ANP) binding, with an IC50 of 4x 10(-7) M. It also inhibits ANP-activated particulate guanylate cyclase from rat kidney, heart and brain membranes in dose-dependent fashion, varying also with ANP concentration. Isatin 35-41 natriuretic peptide A Rattus norvegicus 155-181 7475958-3 1995 In the present study, we show that isatin has little effect on a wide range of neurotransmitter and hormonal receptors but that it acts as an inhibitor of atrial natriuretic peptide (ANP) binding, with an IC50 of 4x 10(-7) M. It also inhibits ANP-activated particulate guanylate cyclase from rat kidney, heart and brain membranes in dose-dependent fashion, varying also with ANP concentration. Isatin 35-41 natriuretic peptide A Rattus norvegicus 183-186 7475958-3 1995 In the present study, we show that isatin has little effect on a wide range of neurotransmitter and hormonal receptors but that it acts as an inhibitor of atrial natriuretic peptide (ANP) binding, with an IC50 of 4x 10(-7) M. It also inhibits ANP-activated particulate guanylate cyclase from rat kidney, heart and brain membranes in dose-dependent fashion, varying also with ANP concentration. Isatin 35-41 natriuretic peptide A Rattus norvegicus 243-246 7475958-3 1995 In the present study, we show that isatin has little effect on a wide range of neurotransmitter and hormonal receptors but that it acts as an inhibitor of atrial natriuretic peptide (ANP) binding, with an IC50 of 4x 10(-7) M. It also inhibits ANP-activated particulate guanylate cyclase from rat kidney, heart and brain membranes in dose-dependent fashion, varying also with ANP concentration. Isatin 35-41 natriuretic peptide A Rattus norvegicus 243-246 7475958-4 1995 These findings suggest that isatin is a new endogenous regulator of mammalian ANP activity, with potential implications for the control of both anxiety and natriuresis. Isatin 28-34 natriuretic peptide A Homo sapiens 78-81 7829161-1 1994 Isatin (10 microM) strongly inhibited the activity of rat brain monoamine oxidase-B (MAO-B) in vitro. Isatin 0-6 monoamine oxidase B Rattus norvegicus 64-83 7829161-1 1994 Isatin (10 microM) strongly inhibited the activity of rat brain monoamine oxidase-B (MAO-B) in vitro. Isatin 0-6 monoamine oxidase B Rattus norvegicus 85-90 1768136-5 1991 Isatin (indole-2,3-dione) was produced as an intermediate when the consortium was amended with oxindole, providing evidence that degradation of indole proceeded through successive hydroxylation of the 2- and 3-positions prior to ring cleavage between the C-2 and C-3 atoms on the pyrrole ring of indole. Isatin 8-24 complement C2 Homo sapiens 255-266 34932350-2 2022 The proposed preferential mechanistic scenario here undergoes three major steps: first, 3-methyl-2-pyrazolin-5-one converts to its enol form and then, the aldol addition reaction takes place between isatin and enol to generate the intermediate INT2, followed finally by the tautomerization of INT2 to become the product 3-pyrazolone. Isatin 199-205 fibroblast growth factor 3 Homo sapiens 244-248 1688707-0 1990 Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. Isatin 24-30 monoamine oxidase A Rattus norvegicus 46-49 1688707-1 1990 A study of the acute effects of isatin, an endogenous MAO inhibitor related to tribulin, on rat brain serotonergic function was undertaken. Isatin 32-38 monoamine oxidase A Rattus norvegicus 54-57 1691454-1 1990 Isatin (Tribulin) produced a dose-dependent inhibition of both MAO A and MAO B in broken cell preparations from rat brain and pineal. Isatin 0-6 monoamine oxidase A Homo sapiens 63-68 1691454-1 1990 Isatin (Tribulin) produced a dose-dependent inhibition of both MAO A and MAO B in broken cell preparations from rat brain and pineal. Isatin 0-6 monoamine oxidase B Homo sapiens 73-78 1691454-5 1990 However, the diazepam augmentation of beta adrenergic induction of serotonin N-acetyltransferase activity was blocked by isatin. Isatin 121-127 aralkylamine N-acetyltransferase Rattus norvegicus 67-96 22033021-0 2012 Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody. Isatin 13-19 caspase 3 Mus musculus 31-40 22033021-2 2012 We evaluated the ability of radiolabeled isatins to quantify caspase-3 activity induced by the activation of the extrinsic apoptotic pathway by the anti-Fas antibody in mice. Isatin 41-48 caspase 3 Mus musculus 61-70 22033021-9 2012 The isatin [(18)F]WC-II-89 was retained at statistically significantly higher levels in the organs after anti-Fas antibody treatment while [(99m)Tc]mebrofenin activity cleared, suggesting specific binding to activated caspase-3, but the magnitude of increased binding was still relatively low. Isatin 4-10 caspase 3 Mus musculus 218-227 22033021-11 2012 CONCLUSIONS: The radiolabeled isatins appear to bind specifically to caspase-3 in vivo, but their sensitivity is limited. Isatin 30-37 caspase 3 Mus musculus 69-78 34990933-4 2022 Both series yielded low micromolar selective inhibitors of human MAO-B, namely indole 2 (IC50 = 12.63 +- 1.21 microM) and piperazine 39 (IC50 = 19.25 +- 4.89 microM), which is comparable to selective MAO-B inhibitor isatin (IC50 = 6.10 +- 2.81 microM), yet less potent in comparison to safinamide (IC50 = 0.029 +- 0.002 microM). Isatin 216-222 monoamine oxidase B Homo sapiens 65-70 34990933-4 2022 Both series yielded low micromolar selective inhibitors of human MAO-B, namely indole 2 (IC50 = 12.63 +- 1.21 microM) and piperazine 39 (IC50 = 19.25 +- 4.89 microM), which is comparable to selective MAO-B inhibitor isatin (IC50 = 6.10 +- 2.81 microM), yet less potent in comparison to safinamide (IC50 = 0.029 +- 0.002 microM). Isatin 216-222 monoamine oxidase B Homo sapiens 200-205 34889095-1 2022 A cascade assembly between isatin-derived Morita-Baylis-Hillman carbonates and o-hydroxybenzylideneacetones has been developed under the relay catalysis of Pd(PPh3)4 and DBU, affording a spectrum of 1,2,3,4-tetrahydrodibenzo(b,d)furan architectures incorporating a spirooxindole motif in moderate to good yields with excellent diastereoselectivity. Isatin 27-33 caveolin 1 Homo sapiens 159-163 33764269-4 2021 To test this hypothesis, a total of 79 isatin derivatives, which inhibited Mpro activity under in vitro conditions, were selected from the literature, and then screened through AutoDock Vina. Isatin 39-45 NEWENTRY Severe acute respiratory syndrome-related coronavirus 75-79 34932350-2 2022 The proposed preferential mechanistic scenario here undergoes three major steps: first, 3-methyl-2-pyrazolin-5-one converts to its enol form and then, the aldol addition reaction takes place between isatin and enol to generate the intermediate INT2, followed finally by the tautomerization of INT2 to become the product 3-pyrazolone. Isatin 199-205 fibroblast growth factor 3 Homo sapiens 293-297 34637598-4 2022 Enzyme kinetics studies revealed that the isatin-based carbohydrazones are reversible inhibitors for both FAAH and MAGL. Isatin 42-48 fatty acid amide hydrolase Homo sapiens 106-110 34637598-4 2022 Enzyme kinetics studies revealed that the isatin-based carbohydrazones are reversible inhibitors for both FAAH and MAGL. Isatin 42-48 monoglyceride lipase Homo sapiens 115-119 34530651-1 2021 The hybrid method of the Electron-Conformational Genetic Algorithm (EC-GA) was used to determine the pharmacophore groups and to estimate anticancer activity in isatin derivatives using a robust 4D-QSAR software (EMRE). Isatin 161-167 single-pass membrane protein with aspartate rich tail 1 Homo sapiens 213-217 34600331-3 2021 Herein, we report the novel and highly potent inhibitors of alpha-amylase and alpha-glucosidase, namely isatin-hydrazide conjugates 1a - 1j that are easily accessed in two steps from simple and inexpensive commercially available isatin. Isatin 229-235 sucrase-isomaltase Homo sapiens 78-95 35618489-6 2022 The 3D-QSAR model was developed using reported indole-2,3-diones based ALDH1A1 inhibitors, which provided field points in terms of electrostatic, van der Waals and hydrophobic potentials required for selectively inhibiting ALDH1A1. Isatin 47-64 aldehyde dehydrogenase 1 family member A1 Homo sapiens 71-78 34310996-0 2021 Modification with N-benzylisatin restricts stress-induced aggregation of hen egg white lysozyme: Anti-amyloidogenic property of isatin derivative with possible clinical implications. Isatin 128-134 lysozyme Homo sapiens 87-95 35398259-7 2022 AKR1C1 and AKR1C4 also showed broad substrate specificity for nonsteroidal carbonyl compounds including endogenous 4-oxo-2-nonenal, 4-hydroxy-nonenal, acrolein, isocaproaldehyde, farnesal, isatin and methylglyoxal, of which 4-oxo-2-nonenal was reduced with the lowest Km value of 0.9microM. Isatin 189-195 aldo-keto reductase family 1 member C1 Homo sapiens 0-6 35398259-7 2022 AKR1C1 and AKR1C4 also showed broad substrate specificity for nonsteroidal carbonyl compounds including endogenous 4-oxo-2-nonenal, 4-hydroxy-nonenal, acrolein, isocaproaldehyde, farnesal, isatin and methylglyoxal, of which 4-oxo-2-nonenal was reduced with the lowest Km value of 0.9microM. Isatin 189-195 aldo-keto reductase family 1 member C4 Homo sapiens 11-17 35618489-6 2022 The 3D-QSAR model was developed using reported indole-2,3-diones based ALDH1A1 inhibitors, which provided field points in terms of electrostatic, van der Waals and hydrophobic potentials required for selectively inhibiting ALDH1A1. Isatin 47-64 aldehyde dehydrogenase 1 family member A1 Homo sapiens 223-230 35601305-3 2022 Isatin is an endogenous small fragment, reversible inhibitor for MAO enzymes and is more selective for MAO-B than -A. Isatin 0-6 monoamine oxidase B Homo sapiens 103-108 35601305-6 2022 Isatin has a polypharmacological profile in medicinal chemistry, is a reversible inhibitor for both the MAOs, and shows high selectivity potent inhibition for MAO-B. Isatin 0-6 monoamine oxidase B Homo sapiens 159-164 35453384-5 2022 Isatin ameliorated the deleterious effects of DENA/2-AAF on liver function as evidenced by reduced serum levels of AST, ALT, total bilirubin, albumin, and liver tumor biomarkers (CA19.9 and AFP) compared to control DENA/2-AAF-treated rats. Isatin 0-6 alpha-fetoprotein Rattus norvegicus 190-193 35453384-8 2022 Moreover, isatin significantly reduced the DENA/2-AAF-induced decrease in hepatic expression of anti-apoptotic Bcl2 and the DENA/2-AAF-induced increases in pro-inflammatory and pro-apoptotic factors (TNF-alpha, NF-kappaB p50, NF-kappaB p65, p53, and caspase 3). Isatin 10-16 BCL2, apoptosis regulator Rattus norvegicus 111-115 35453384-8 2022 Moreover, isatin significantly reduced the DENA/2-AAF-induced decrease in hepatic expression of anti-apoptotic Bcl2 and the DENA/2-AAF-induced increases in pro-inflammatory and pro-apoptotic factors (TNF-alpha, NF-kappaB p50, NF-kappaB p65, p53, and caspase 3). Isatin 10-16 tumor necrosis factor Rattus norvegicus 200-209 35453384-8 2022 Moreover, isatin significantly reduced the DENA/2-AAF-induced decrease in hepatic expression of anti-apoptotic Bcl2 and the DENA/2-AAF-induced increases in pro-inflammatory and pro-apoptotic factors (TNF-alpha, NF-kappaB p50, NF-kappaB p65, p53, and caspase 3). Isatin 10-16 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 241-244 35453384-8 2022 Moreover, isatin significantly reduced the DENA/2-AAF-induced decrease in hepatic expression of anti-apoptotic Bcl2 and the DENA/2-AAF-induced increases in pro-inflammatory and pro-apoptotic factors (TNF-alpha, NF-kappaB p50, NF-kappaB p65, p53, and caspase 3). Isatin 10-16 caspase 3 Rattus norvegicus 250-259 35378040-3 2022 The two-step one-pot 1,6-conjugate addition provides effective access to a series of isatin-incorporated phosphate-bearing 1,6-adducts having two vicinal tertiary carbons with up to 90% yield and >20:1 dr. Isatin 85-91 protection of telomeres 1 Homo sapiens 17-22