PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29588470-1	2018	Epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 epoxygenases from arachidonic acid, and their rapid metabolism is mainly through soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2	Homo sapiens	146-171
29290096-2	2018	CYP-450 epoxygenase metabolizes AA to epoxyeicosatrienoic acids (EETs).	eets	65-69	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-7
29588470-1	2018	Epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 epoxygenases from arachidonic acid, and their rapid metabolism is mainly through soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2	Homo sapiens	173-176
29427791-2	2018	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acids to form epoxyeicosatrienoic acids (EETs), which exert beneficial roles in the cardiovascular system, but their role in alcoholic cardiomyopathy is elusive.	eets	99-103	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
29427791-2	2018	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acids to form epoxyeicosatrienoic acids (EETs), which exert beneficial roles in the cardiovascular system, but their role in alcoholic cardiomyopathy is elusive.	eets	99-103	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	17-20
29433675-2	2018	CYP2J2 inhibitors can significantly reduce proliferation, migration and promote apoptosis of tumor cells by inhibiting epoxyeicosatrienoic acids (EETs) biosynthesis.	eets	146-150	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
28958841-1	2017	Cardiac enzymes such as cytochrome P450 2J2 (CYP2J2) metabolize arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs), which in turn are metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	eets	133-137	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	24-43
29529602-1	2018	BACKGROUND/AIMS: We found recently that increasing renal epoxyeicosatrienoic acids (EETs) levels by blocking soluble epoxide hydrolase (sEH), an enzyme responsible for EETs degradation, shows renoprotective actions and retards the progression of chronic kidney disease (CKD) in Ren-2 transgenic hypertensive rats (TGR) after 5/6 renal ablation (5/6 NX).	eets	84-88	epoxide hydrolase 2	Rattus norvegicus	109-134
29529602-1	2018	BACKGROUND/AIMS: We found recently that increasing renal epoxyeicosatrienoic acids (EETs) levels by blocking soluble epoxide hydrolase (sEH), an enzyme responsible for EETs degradation, shows renoprotective actions and retards the progression of chronic kidney disease (CKD) in Ren-2 transgenic hypertensive rats (TGR) after 5/6 renal ablation (5/6 NX).	eets	84-88	epoxide hydrolase 2	Rattus norvegicus	136-139
28958841-1	2017	Cardiac enzymes such as cytochrome P450 2J2 (CYP2J2) metabolize arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs), which in turn are metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	eets	133-137	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	45-51
28958841-1	2017	Cardiac enzymes such as cytochrome P450 2J2 (CYP2J2) metabolize arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs), which in turn are metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	eets	133-137	epoxide hydrolase 2	Homo sapiens	173-198
28958841-1	2017	Cardiac enzymes such as cytochrome P450 2J2 (CYP2J2) metabolize arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs), which in turn are metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	eets	133-137	epoxide hydrolase 2	Homo sapiens	200-203
28874838-1	2017	TRPV4 cation channel activation by cytochrome P450-mediated derivatives of arachidonic acid (AA), epoxyeicosatrienoic acids (EETs), constitute a major mechanisms of endothelium-derived vasodilatation.	eets	125-129	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
28919040-2	2017	CYP3A4 was unexpectedly associated with breast cancer mitochondria and synthesized arachidonic acid (AA)-derived epoxyeicosatrienoic acids (EETs), which promoted the electron transport chain/respiration and inhibited AMPKalpha.	eets	140-144	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
29285425-1	2017	Background: Soluble epoxide hydrolase (sEH) expressed by endothelial cells catalyzes the metabolism of epoxyeicosatrienoic acids (EETs), which are vasoactive agents.	eets	130-134	epoxide hydrolase 2	Homo sapiens	12-37
29285425-1	2017	Background: Soluble epoxide hydrolase (sEH) expressed by endothelial cells catalyzes the metabolism of epoxyeicosatrienoic acids (EETs), which are vasoactive agents.	eets	130-134	epoxide hydrolase 2	Homo sapiens	39-42
28741242-1	2017	A still growing body of evidence suggests the importance of epoxyeicosatrienoic acids (EETs) in the regulation of inflammatory response; therefore, drugs that stabilize their levels by targeting the soluble epoxide hydrolase (sEH), an enzyme responsible for their metabolism, are currently under investigation.	eets	87-91	epoxide hydrolase 2	Rattus norvegicus	199-224
28822809-1	2017	Epoxyeicostrienoic acids (EETs) are arachidonic acid derived meditators which are catalyzed by soluble epoxide hydrolase (sEH) to less active dihydroeicostrienoics acids (DHETS).	eets	26-30	epoxide hydrolase 2	Rattus norvegicus	95-120
28839250-2	2017	Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs).	eets	235-239	arachidonate 5-lipoxygenase	Homo sapiens	12-26
28839250-2	2017	Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs).	eets	235-239	arachidonate 5-lipoxygenase activating protein	Homo sapiens	47-51
28839250-2	2017	Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs).	eets	235-239	arachidonate 5-lipoxygenase	Homo sapiens	82-96
28839250-2	2017	Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs).	eets	235-239	arachidonate 5-lipoxygenase	Homo sapiens	98-103
28839250-2	2017	Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs).	eets	235-239	epoxide hydrolase 2	Homo sapiens	149-174
28839250-2	2017	Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs).	eets	235-239	epoxide hydrolase 2	Homo sapiens	176-179
28319086-1	2017	Epoxyeicosatrienoic acids (EETs) are the epoxidation products of arachidonic acid catalyzed by cytochrome P450 (CYP) epoxygenases, which possess multiple biological activities.	eets	27-31	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	95-110
28319086-1	2017	Epoxyeicosatrienoic acids (EETs) are the epoxidation products of arachidonic acid catalyzed by cytochrome P450 (CYP) epoxygenases, which possess multiple biological activities.	eets	27-31	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	112-115
28890385-2	2017	Adenosine A2AAR-deficient (A2AAR-/-) mice have increased expression of soluble epoxide hydrolase (sEH); the enzyme responsible for breaking down the cardioprotective epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs).	eets	193-197	adenosine A2a receptor	Mus musculus	10-15
28890385-2	2017	Adenosine A2AAR-deficient (A2AAR-/-) mice have increased expression of soluble epoxide hydrolase (sEH); the enzyme responsible for breaking down the cardioprotective epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs).	eets	193-197	adenosine A2a receptor	Mus musculus	27-35
28890385-2	2017	Adenosine A2AAR-deficient (A2AAR-/-) mice have increased expression of soluble epoxide hydrolase (sEH); the enzyme responsible for breaking down the cardioprotective epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs).	eets	193-197	epoxide hydrolase 2, cytoplasmic	Mus musculus	71-96
28104457-4	2017	EETs are metabolized to less active metabolites by the enzyme soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2, cytoplasmic	Mus musculus	62-87
28104457-4	2017	EETs are metabolized to less active metabolites by the enzyme soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2, cytoplasmic	Mus musculus	89-92
28411230-9	2017	Deletion of 12/15-LOX in mice led to increased cytochrome P-450-derived bioactive lipid mediator epoxyeicosatrienoic acids (EETs), i.e., 11,12-EpETrE and 14,15-EpETrE, which were further enhanced by acute PUFA intake post-MI.	eets	124-128	arachidonate 15-lipoxygenase	Mus musculus	18-21
28473204-3	2017	Cirrhotic tissues had a higher ratio of epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs) following increased CYP2C11 expression, which may be a protective response.	eets	67-71	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	134-141
28890385-2	2017	Adenosine A2AAR-deficient (A2AAR-/-) mice have increased expression of soluble epoxide hydrolase (sEH); the enzyme responsible for breaking down the cardioprotective epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs).	eets	193-197	epoxide hydrolase 2, cytoplasmic	Mus musculus	98-101
28822809-1	2017	Epoxyeicostrienoic acids (EETs) are arachidonic acid derived meditators which are catalyzed by soluble epoxide hydrolase (sEH) to less active dihydroeicostrienoics acids (DHETS).	eets	26-30	epoxide hydrolase 2	Rattus norvegicus	122-125
28822809-4	2017	Our results showed that hepatic sEH expression was markedly increased in portal hypertension, and led to a lower ratio of EETs/DHETs which was effectively reversed by t-TUCB administration.	eets	122-126	epoxide hydrolase 2	Rattus norvegicus	32-35
28827137-1	2017	To test the hypothesis that VitC downregulates soluble epoxide hydrolase (sEH, responsible for converting EETs to DHETs) to stabilize tissue EETs, the heart, lung, liver, kidney, and mesenteric arteries isolated from normal rats were incubated with VitC (1000muM) for 72h, and tissue sEH expression, along with EET and DHET profiles were assessed.	eets	106-110	epoxide hydrolase 2	Rattus norvegicus	47-72
28827137-1	2017	To test the hypothesis that VitC downregulates soluble epoxide hydrolase (sEH, responsible for converting EETs to DHETs) to stabilize tissue EETs, the heart, lung, liver, kidney, and mesenteric arteries isolated from normal rats were incubated with VitC (1000muM) for 72h, and tissue sEH expression, along with EET and DHET profiles were assessed.	eets	106-110	epoxide hydrolase 2	Rattus norvegicus	74-77
28827137-3	2017	The functional consequence of reduced sEH expression was validated by LC/MS/MS-based analysis, indicating that in VitC-treated tissues that displayed downregulation of sEH mRNA and protein expression, total DHETs were significantly lower, accompanied with a greater ratio of EETs/DHETs than those in VitC-untreated groups.	eets	275-279	epoxide hydrolase 2	Rattus norvegicus	38-41
28827137-3	2017	The functional consequence of reduced sEH expression was validated by LC/MS/MS-based analysis, indicating that in VitC-treated tissues that displayed downregulation of sEH mRNA and protein expression, total DHETs were significantly lower, accompanied with a greater ratio of EETs/DHETs than those in VitC-untreated groups.	eets	275-279	epoxide hydrolase 2	Rattus norvegicus	168-171
28713267-2	2017	Epoxyeicosatrienoic acids (EETs) are Cyp epoxygenase arachidonic acid metabolites that demonstrate biological actions that result in kidney protection.	eets	27-31	peptidyl-prolyl isomerase G (cyclophilin G)	Mus musculus	37-40
28002622-1	2017	Epoxyeicosatrienoic acids (EETs) are synthesized in astrocytes, and inhibitors of soluble epoxide hydrolase (sEH), which hydrolyzes EETs, reduce infarct volume in ischemic stroke.	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	82-107
27753791-8	2017	In addition, in vitro experiments revealed that both TPPU and EETs (11,12-EET and 14,15-EET) suppressed the expression of IL-1beta and TNF-alpha, and LDH release in RAW264.7 cells.	eets	62-66	interleukin 1 beta	Mus musculus	122-130
27753791-8	2017	In addition, in vitro experiments revealed that both TPPU and EETs (11,12-EET and 14,15-EET) suppressed the expression of IL-1beta and TNF-alpha, and LDH release in RAW264.7 cells.	eets	62-66	tumor necrosis factor	Mus musculus	135-144
28616567-2	2017	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues.	eets	27-31	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	72-79
28384353-3	2017	Microsomal epoxide hydrolase (EPHX1, mEH) and soluble epoxide hydrolase (EPHX2, sEH) were identified >30 years ago and are capable of hydrolyzing EETs to DHETs.	eets	149-153	epoxide hydrolase 1, microsomal	Mus musculus	0-28
28384353-3	2017	Microsomal epoxide hydrolase (EPHX1, mEH) and soluble epoxide hydrolase (EPHX2, sEH) were identified >30 years ago and are capable of hydrolyzing EETs to DHETs.	eets	149-153	epoxide hydrolase 1, microsomal	Mus musculus	30-35
28384353-3	2017	Microsomal epoxide hydrolase (EPHX1, mEH) and soluble epoxide hydrolase (EPHX2, sEH) were identified >30 years ago and are capable of hydrolyzing EETs to DHETs.	eets	149-153	epoxide hydrolase 1, microsomal	Mus musculus	37-40
28384353-3	2017	Microsomal epoxide hydrolase (EPHX1, mEH) and soluble epoxide hydrolase (EPHX2, sEH) were identified >30 years ago and are capable of hydrolyzing EETs to DHETs.	eets	149-153	epoxide hydrolase 2, cytoplasmic	Mus musculus	73-78
28384353-3	2017	Microsomal epoxide hydrolase (EPHX1, mEH) and soluble epoxide hydrolase (EPHX2, sEH) were identified >30 years ago and are capable of hydrolyzing EETs to DHETs.	eets	149-153	epoxide hydrolase 2, cytoplasmic	Mus musculus	80-83
28356494-1	2017	Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid derived from the cytochrome P450 enzymes, are mainly metabolized by soluble epoxide hydrolase (sEH) to their corresponding diols.	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	134-159
27782740-2	2017	Recent studies have revealed striking differences in the role of epoxyeicosatrienoic acids (EETs), active products of cytochrome P-450-dependent epoxygenase pathway of arachidonic acid, in the progression of aorto-caval fistula (ACF)-induced CHF between hypertensive Ren-2 renin transgenic rats (TGR) and transgene-negative normotensive Hannover Sprague-Dawley (HanSD) controls.	eets	92-96	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	118-134
28002622-1	2017	Epoxyeicosatrienoic acids (EETs) are synthesized in astrocytes, and inhibitors of soluble epoxide hydrolase (sEH), which hydrolyzes EETs, reduce infarct volume in ischemic stroke.	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	109-112
28218273-4	2017	The soluble epoxide hydrolase (sEH) converts AA-derived anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatetraenoic acids (di-HETEs).	eets	101-105	epoxide hydrolase 2	Homo sapiens	4-29
28218273-4	2017	The soluble epoxide hydrolase (sEH) converts AA-derived anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatetraenoic acids (di-HETEs).	eets	101-105	epoxide hydrolase 2	Homo sapiens	31-34
28007573-1	2017	OBJECTIVE: Prominent among the endothelium-derived hyperpolarizing factors (EDHFs) are the Cytochrome P450 (CYP) epoxygenase-derived arachidonic acid metabolites-the epoxyeicosatrienoic acids (EETs), that are known as vasodilators in the microcirculation.	eets	193-197	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	91-106
28007573-1	2017	OBJECTIVE: Prominent among the endothelium-derived hyperpolarizing factors (EDHFs) are the Cytochrome P450 (CYP) epoxygenase-derived arachidonic acid metabolites-the epoxyeicosatrienoic acids (EETs), that are known as vasodilators in the microcirculation.	eets	193-197	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	108-111
28332266-1	2017	Epoxyeicosatrienoic acids (EETs) are endogenous ligands that undergo hydrolysis by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	83-108
28332266-1	2017	Epoxyeicosatrienoic acids (EETs) are endogenous ligands that undergo hydrolysis by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	110-113
28293507-4	2016	Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are inactivated by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	109-134
29911373-2	2017	CYP2J2 can convert arachidonic acid (AA) to expoxyeicosatrienoic acids (EETs), which have various biological effects, implying the important role of CYP2J2 in the regulation of cardiovascular system and promotion of tumor progression and metastasis.	eets	72-76	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
29911373-2	2017	CYP2J2 can convert arachidonic acid (AA) to expoxyeicosatrienoic acids (EETs), which have various biological effects, implying the important role of CYP2J2 in the regulation of cardiovascular system and promotion of tumor progression and metastasis.	eets	72-76	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	149-155
29138698-1	2017	Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid and metabolized by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2	Homo sapiens	86-111
29138698-1	2017	Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid and metabolized by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2	Homo sapiens	113-116
27924507-3	2016	Inhibition of soluble epoxide hydrolase (sEH) metabolism has been shown to effectively increase the accumulation of epoxyeicosatrienoic acids (EETs), which are cytochrome P450 metabolites of arachidonic acid and have been demonstrated to have neuroprotective effects.	eets	143-147	epoxide hydrolase 2	Homo sapiens	14-39
27663770-2	2016	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues.	eets	27-31	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	72-79
26838043-7	2016	mEH E404D animals also showed faster metabolization of a specific class of endogenous eicosanoids, arachidonic acid-derived epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs).	eets	151-155	epoxide hydrolase 1, microsomal	Mus musculus	0-3
26838043-8	2016	Significantly higher DHETs/EETs ratios were found in mEH E404D liver, urine, plasma, brain and cerebral endothelial cells compared to WT controls, suggesting a broad impact of the mEH mutant on endogenous EETs metabolism.	eets	27-31	epoxide hydrolase 1, microsomal	Mus musculus	53-56
27966642-3	2016	In TNFalpha-stimulated primary human retinal microvascular endothelial cells, total levels of epoxyeicosatrienoic acids (EETs), but not epoxydocosapentaenoic acids (EDPs), were significantly decreased.	eets	121-125	tumor necrosis factor	Homo sapiens	3-11
27815261-3	2016	Epoxyeicosatrienoic acids (EETs) are pulmonary vasoconstrictors, which are metabolized to less vasoactive dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	147-172
27815261-3	2016	Epoxyeicosatrienoic acids (EETs) are pulmonary vasoconstrictors, which are metabolized to less vasoactive dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	174-177
27924507-3	2016	Inhibition of soluble epoxide hydrolase (sEH) metabolism has been shown to effectively increase the accumulation of epoxyeicosatrienoic acids (EETs), which are cytochrome P450 metabolites of arachidonic acid and have been demonstrated to have neuroprotective effects.	eets	143-147	epoxide hydrolase 2	Homo sapiens	41-44
27087514-1	2016	AIM: To better understand the relationship between the interactions among rs17110453, rs751141, and rs9333025 variants and plasma levels of cytochrome P450 (CYP) metabolites, i.e.,20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DiHETEs) in ischemia stroke (IS).	eets	250-254	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	157-160
27591243-1	2016	Epoxyeicosatrienoic acids (EETs) are metabolic products of free arachidonic acid, which are produced through cytochrome P-450 (CYP) epoxygenases.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	109-125
27591243-1	2016	Epoxyeicosatrienoic acids (EETs) are metabolic products of free arachidonic acid, which are produced through cytochrome P-450 (CYP) epoxygenases.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	127-130
27878278-3	2016	However, EETs are not stable in vivo, and are rapidly degraded to the biologically less active metabolites, dihydroxyeicosatrienoic acids, via soluble epoxide hydrolase (sEH).	eets	9-13	epoxide hydrolase 2, cytoplasmic	Mus musculus	143-168
27878278-3	2016	However, EETs are not stable in vivo, and are rapidly degraded to the biologically less active metabolites, dihydroxyeicosatrienoic acids, via soluble epoxide hydrolase (sEH).	eets	9-13	epoxide hydrolase 2, cytoplasmic	Mus musculus	170-173
27488890-3	2016	sEH converts EETs into dihydroxyeicosatrienoic-acids (DHETs).	eets	13-17	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
26975734-1	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to generate epoxyeicosatrienoic acids (EETs).	eets	102-106	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
26975734-1	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to generate epoxyeicosatrienoic acids (EETs).	eets	102-106	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
27416746-1	2016	Cytochrome P450 epoyxgenase 2J2 and epoxyeicosatrienoic acids (EETs) are known to protect against cardiac hypertrophy and heart failure, which involve the activation of 5"-AMP-activated protein kinase (AMPK) and Akt.	eets	63-67	thymoma viral proto-oncogene 1	Mus musculus	212-215
27401401-2	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into bioactive epoxyeicosatrienoic acids (EETs), which have potent anti-inflammatory and protective effects.	eets	105-109	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-15
27358055-5	2016	Cytochrome P-450 epoxygenase metabolites of arachidonic acid, epoxyeicosatrienoic acids (EETs), have potent vasodilator and antihypertensive properties in addition to many cytoprotective effects, but their effects on CNI-induced nephrotoxicity have not been explored.	eets	89-93	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
27496380-2	2016	Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid, are known to have anti-inflammatory effects and are hydrolyzed by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	133-158
27496380-2	2016	Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid, are known to have anti-inflammatory effects and are hydrolyzed by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	160-163
27184755-3	2016	EETs can be further metabolized to less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2	Homo sapiens	88-113
27184755-3	2016	EETs can be further metabolized to less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2	Homo sapiens	115-118
27583776-3	2016	sEH is involved in the main catabolic pathway of epoxyeicosatrienoic acids (EETs), which are converted into dihydroxyeicosatrienoic acids (DHETs).	eets	76-80	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
27683613-1	2016	Epoxyeicosatrienoicacids (EETs), synthesized from arachidonic acid by epoxygenases of the CYP2C and CYP2J gene subfamilies, contribute to hypoxic pulmonary vasoconstriction (HPV) in mice.	eets	26-30	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	90-95
27401401-2	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into bioactive epoxyeicosatrienoic acids (EETs), which have potent anti-inflammatory and protective effects.	eets	105-109	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	17-20
27372879-6	2016	Therefore, by increasing the half life of endogenous EETs in vivo via inhibition of sEH, its metabolizing enzyme can, therefore, constitutes an important therapeutic strategy in PD.	eets	53-57	epoxide hydrolase 2	Homo sapiens	84-87
27252474-7	2016	Similar results were obtained with the administration of miconazole, which inhibits the biosynthesis of epoxyeicosatrienoic acids (EETs), endogenous agonists for TRPV4, from arachidonic acid (AA).	eets	131-135	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	162-167
27115337-1	2016	BACKGROUND: Epoxyeicosatrienoic acids (EETs) derived from cytochrome P450 (CYP)-dependent metabolism of arachidonic acid are increased in the plasma of women with preeclampsia as compared with normal pregnancy and are significantly higher in fetal than in maternal plasma and erythrocytes.	eets	39-43	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	58-73
27092411-1	2016	Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) in the metabolic pathway of arachidonic acid and has been considered as an important therapeutic target for chronic diseases such as hypertension, diabetes and inflammation.	eets	70-74	epoxide hydrolase 2	Homo sapiens	0-25
27092411-1	2016	Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) in the metabolic pathway of arachidonic acid and has been considered as an important therapeutic target for chronic diseases such as hypertension, diabetes and inflammation.	eets	70-74	epoxide hydrolase 2	Homo sapiens	27-30
27115337-1	2016	BACKGROUND: Epoxyeicosatrienoic acids (EETs) derived from cytochrome P450 (CYP)-dependent metabolism of arachidonic acid are increased in the plasma of women with preeclampsia as compared with normal pregnancy and are significantly higher in fetal than in maternal plasma and erythrocytes.	eets	39-43	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	75-78
27079253-3	2016	Epoxyecosatrienoic acids (EETs), the products of arachidonic acid metabolism mediated by cytochrome P450 (CYP) 2J, 2C and other isoforms, are regulated by soluble epoxide hydrolase (sEH)-catalyzed conversion into less active diols.	eets	26-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-104
27016584-1	2016	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via CYP/epoxygenases, which are catabolized by soluble epoxide hydrolase (sEH) and known to possess cardioprotective properties.	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	116-141
27016584-1	2016	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via CYP/epoxygenases, which are catabolized by soluble epoxide hydrolase (sEH) and known to possess cardioprotective properties.	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	143-146
27354541-1	2016	Epoxyeicosatrienoic acids (EETs) are cardioprotective mediators metabolized by soluble epoxide hydrolase (sEH) to form corresponding diols (DHETs).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	79-104
27354541-1	2016	Epoxyeicosatrienoic acids (EETs) are cardioprotective mediators metabolized by soluble epoxide hydrolase (sEH) to form corresponding diols (DHETs).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	106-109
26686738-3	2016	CYP plasma metabolite levels [20-hydroxyeicosatetraenoic acid (HETE), total epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DiHETEs)] were assessed in a subsample of 90 patients with carotid stenosis and 96 patients without carotid stenosis.	eets	103-107	peptidylprolyl isomerase G	Homo sapiens	0-3
27100515-1	2016	Cytochrome P450s enzymes catalyze the metabolism of arachidonic acid to epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid and hydroxyeicosatetraeonic acid (HETEs).	eets	99-103	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
27079253-3	2016	Epoxyecosatrienoic acids (EETs), the products of arachidonic acid metabolism mediated by cytochrome P450 (CYP) 2J, 2C and other isoforms, are regulated by soluble epoxide hydrolase (sEH)-catalyzed conversion into less active diols.	eets	26-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	106-109
27079253-3	2016	Epoxyecosatrienoic acids (EETs), the products of arachidonic acid metabolism mediated by cytochrome P450 (CYP) 2J, 2C and other isoforms, are regulated by soluble epoxide hydrolase (sEH)-catalyzed conversion into less active diols.	eets	26-30	epoxide hydrolase 2	Homo sapiens	155-180
27079253-3	2016	Epoxyecosatrienoic acids (EETs), the products of arachidonic acid metabolism mediated by cytochrome P450 (CYP) 2J, 2C and other isoforms, are regulated by soluble epoxide hydrolase (sEH)-catalyzed conversion into less active diols.	eets	26-30	epoxide hydrolase 2	Homo sapiens	182-185
26727266-1	2016	AIM: 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-dependent eicosanoids that play opposite roles in the regulation of vascular tone, inflammation, and apoptosis.	eets	78-82	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	88-103
26918316-1	2016	Cytochrome P450 (P450) enzymes metabolize arachidonic acid (AA) to several biologically active epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs).	eets	122-126	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-21
25663200-3	2016	Soluble epoxide hydrolase (sEH) is an endogenous key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs).	eets	158-162	epoxide hydrolase 2	Rattus norvegicus	0-25
25663200-3	2016	Soluble epoxide hydrolase (sEH) is an endogenous key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs).	eets	158-162	epoxide hydrolase 2	Rattus norvegicus	27-30
26838069-1	2016	AIM: CYP2J3 in myocardium metabolizes arachidonic acid to 4 regioisomeric epoxyeicosatrienoic acids (EETs), which have diverse biological activities in rat heart.	eets	101-105	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	5-11
26683769-3	2016	The soluble epoxide hydrolase (sEH), a pro-inflammatory enzyme, generally inactivates anti-inflammatory and anti-pain epoxyeicosatrienoic acids (EETs).	eets	145-149	epoxide hydrolase 2, cytoplasmic	Mus musculus	4-29
26683769-3	2016	The soluble epoxide hydrolase (sEH), a pro-inflammatory enzyme, generally inactivates anti-inflammatory and anti-pain epoxyeicosatrienoic acids (EETs).	eets	145-149	epoxide hydrolase 2, cytoplasmic	Mus musculus	31-34
26310139-1	2016	Epoxyeicosatrienoic acids (EETs), the metabolites of arachidonic acid derived from the cytochrome P450 (CYP450) epoxygenases, are mainly metabolized by soluble epoxide hydrolase (sEH) to their corresponding diols.	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	152-177
26310139-1	2016	Epoxyeicosatrienoic acids (EETs), the metabolites of arachidonic acid derived from the cytochrome P450 (CYP450) epoxygenases, are mainly metabolized by soluble epoxide hydrolase (sEH) to their corresponding diols.	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	179-182
26545915-3	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active eicosanoids called epoxyeicosatrienoic acids (EETs), which are further converted by soluble epoxide hydrolase (sEH) to less bioactive diols.	eets	132-136	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
26545915-3	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active eicosanoids called epoxyeicosatrienoic acids (EETs), which are further converted by soluble epoxide hydrolase (sEH) to less bioactive diols.	eets	132-136	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	17-20
26545915-3	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active eicosanoids called epoxyeicosatrienoic acids (EETs), which are further converted by soluble epoxide hydrolase (sEH) to less bioactive diols.	eets	132-136	epoxide hydrolase 2	Rattus norvegicus	170-195
26545915-3	2016	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active eicosanoids called epoxyeicosatrienoic acids (EETs), which are further converted by soluble epoxide hydrolase (sEH) to less bioactive diols.	eets	132-136	epoxide hydrolase 2	Rattus norvegicus	197-200
26727266-1	2016	AIM: 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-dependent eicosanoids that play opposite roles in the regulation of vascular tone, inflammation, and apoptosis.	eets	78-82	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	105-108
26727266-3	2016	EETs are rapidly metabolized to dihydroxyeicosatrienoic acids (DHETs) by the soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2, cytoplasmic	Mus musculus	77-102
26727266-3	2016	EETs are rapidly metabolized to dihydroxyeicosatrienoic acids (DHETs) by the soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2, cytoplasmic	Mus musculus	104-107
26722025-2	2016	In the process of long-standing chronic inflammation, aberrant metabolites of arachidonic acid play a crucial role in promoting carcinogenesis, in which the soluble epoxide hydrolase (sEH), as a pro-inflammatory enzyme, generally inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs).	eets	287-291	epoxide hydrolase 2, cytoplasmic	Mus musculus	157-182
27451096-3	2016	The CYP pathway produces two types of eicosanoid products: epoxyeicosatrienoic acids (EETs), formed by CYP epoxygenases, and hydroxyeicosatetraenoic acids (HETEs), formed by CYP hydroxylases.	eets	86-90	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-7
27451096-3	2016	The CYP pathway produces two types of eicosanoid products: epoxyeicosatrienoic acids (EETs), formed by CYP epoxygenases, and hydroxyeicosatetraenoic acids (HETEs), formed by CYP hydroxylases.	eets	86-90	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-106
27451096-3	2016	The CYP pathway produces two types of eicosanoid products: epoxyeicosatrienoic acids (EETs), formed by CYP epoxygenases, and hydroxyeicosatetraenoic acids (HETEs), formed by CYP hydroxylases.	eets	86-90	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-106
26722025-2	2016	In the process of long-standing chronic inflammation, aberrant metabolites of arachidonic acid play a crucial role in promoting carcinogenesis, in which the soluble epoxide hydrolase (sEH), as a pro-inflammatory enzyme, generally inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs).	eets	287-291	epoxide hydrolase 2, cytoplasmic	Mus musculus	184-187
26747234-7	2016	Several elegant studies have contributed to defining the importance of stabilizing the levels of epoxyeicosatrienoic acids (EETs), by inhibiting or deleting soluble epoxide hydrolase (sEH), in stroke research.	eets	124-128	epoxide hydrolase 2	Homo sapiens	157-182
27144772-1	2016	Soluble epoxide hydrolase (sEH) converts highly active epoxyeicosatrienoic acids (EETs) generated by cytochrome P450 (CYP) epoxygenases from arachidonic acid to less active dihydroxyeicosatrienoic acids.	eets	82-86	epoxide hydrolase 2	Homo sapiens	0-25
27144772-1	2016	Soluble epoxide hydrolase (sEH) converts highly active epoxyeicosatrienoic acids (EETs) generated by cytochrome P450 (CYP) epoxygenases from arachidonic acid to less active dihydroxyeicosatrienoic acids.	eets	82-86	epoxide hydrolase 2	Homo sapiens	27-30
27144772-1	2016	Soluble epoxide hydrolase (sEH) converts highly active epoxyeicosatrienoic acids (EETs) generated by cytochrome P450 (CYP) epoxygenases from arachidonic acid to less active dihydroxyeicosatrienoic acids.	eets	82-86	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	101-116
27144772-1	2016	Soluble epoxide hydrolase (sEH) converts highly active epoxyeicosatrienoic acids (EETs) generated by cytochrome P450 (CYP) epoxygenases from arachidonic acid to less active dihydroxyeicosatrienoic acids.	eets	82-86	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	118-121
26494028-1	2015	BACKGROUND: The soluble epoxide hydrolase (sEH) is an important enzyme chiefly involved in the metabolism of fatty acid signaling molecules termed epoxyeicosatrienoic acids (EETs).	eets	174-178	epoxide hydrolase 2, cytoplasmic	Mus musculus	16-41
26494028-1	2015	BACKGROUND: The soluble epoxide hydrolase (sEH) is an important enzyme chiefly involved in the metabolism of fatty acid signaling molecules termed epoxyeicosatrienoic acids (EETs).	eets	174-178	epoxide hydrolase 2, cytoplasmic	Mus musculus	43-46
26165641-3	2015	Epoxyeicosatrienoic acids (EETs) have an anti-inflammatory effect and are metabolized by soluble epoxide hydrolase (sEH: encoded by EPHX2 gene).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	89-114
26489615-1	2015	The aim of the present study is to investigate how cytochrome P450 enzymes (CYP) 2C8-derived epoxyeicosatrienoic acids (EETs) regulate the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and protect against oxidative stress-induced endothelial injuries in the development and progression of atherosclerosis.	eets	120-124	NFE2 like bZIP transcription factor 2	Homo sapiens	139-182
26489615-1	2015	The aim of the present study is to investigate how cytochrome P450 enzymes (CYP) 2C8-derived epoxyeicosatrienoic acids (EETs) regulate the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and protect against oxidative stress-induced endothelial injuries in the development and progression of atherosclerosis.	eets	120-124	NFE2 like bZIP transcription factor 2	Homo sapiens	184-188
26341485-1	2015	sEH (soluble epoxide hydrolase), which is encoded by the EPHX2 gene, regulates the actions of bioactive lipids, EETs (epoxyeicosatrienoic acids).	eets	112-116	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
26341485-1	2015	sEH (soluble epoxide hydrolase), which is encoded by the EPHX2 gene, regulates the actions of bioactive lipids, EETs (epoxyeicosatrienoic acids).	eets	112-116	epoxide hydrolase 2, cytoplasmic	Mus musculus	5-30
26341485-1	2015	sEH (soluble epoxide hydrolase), which is encoded by the EPHX2 gene, regulates the actions of bioactive lipids, EETs (epoxyeicosatrienoic acids).	eets	112-116	epoxide hydrolase 2, cytoplasmic	Mus musculus	57-62
26165641-3	2015	Epoxyeicosatrienoic acids (EETs) have an anti-inflammatory effect and are metabolized by soluble epoxide hydrolase (sEH: encoded by EPHX2 gene).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	116-119
26165641-3	2015	Epoxyeicosatrienoic acids (EETs) have an anti-inflammatory effect and are metabolized by soluble epoxide hydrolase (sEH: encoded by EPHX2 gene).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	132-137
27076918-2	2015	Previous studies show that epoxyeicosatrienoic acids (EETs) possess promising anti-inflammatory properties, therefore stabilization of EETs and other fatty acid epoxides through inhibition of soluble epoxide hydrolase (sEH) was investigated in mouse models of acute and sub-chronic inflammation caused by TS exposure.	eets	54-58	epoxide hydrolase 2, cytoplasmic	Mus musculus	219-222
25936480-2	2015	Cytochrome P-450 (CYP) is a variegated family of enzymes that, among many other activities, metabolize arachidonic acid to the vasoactive epoxyeicosatrienoic acids (EETs).	eets	165-169	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
25936480-2	2015	Cytochrome P-450 (CYP) is a variegated family of enzymes that, among many other activities, metabolize arachidonic acid to the vasoactive epoxyeicosatrienoic acids (EETs).	eets	165-169	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	18-21
26071213-1	2015	Roles of soluble epoxide hydrolase (sEH), the enzyme responsible for hydrolysis of epoxyeicosatrienoic acids (EETs) to their diols (DHETs), in the coronary circulation and cardiac function remain unknown.	eets	110-114	epoxide hydrolase 2, cytoplasmic	Mus musculus	9-34
26071213-1	2015	Roles of soluble epoxide hydrolase (sEH), the enzyme responsible for hydrolysis of epoxyeicosatrienoic acids (EETs) to their diols (DHETs), in the coronary circulation and cardiac function remain unknown.	eets	110-114	epoxide hydrolase 2, cytoplasmic	Mus musculus	36-39
25733327-4	2015	The sEH is highly expressed in adipocytes, and it converts epoxyeicosatrienoic acids (EETs) into less bioactive dihydroxyeicosatrienoic acids.	eets	86-90	epoxide hydrolase 2, cytoplasmic	Mus musculus	4-7
25679385-2	2015	We screened kidney cell lines for the expression of G-protein-coupled receptor 40 (GPR40) and found that the porcine renal tubular epithelial cell line LLCPKcl4, which has been previously demonstrated to be sensitive to the mitogenic effect of EETs, expresses higher levels of GPR40 mRNA and protein than the human embryonic kidney cell line HEK293.	eets	244-248	free fatty acid receptor 1	Homo sapiens	52-81
25679385-3	2015	EETs induced only a weak mitogenic EGFR signaling and mild cell proliferation in HEK293 cells.	eets	0-4	epidermal growth factor receptor	Homo sapiens	35-39
25642188-1	2014	Soluble epoxide hydrolase (sEH), a key enzyme in the metabolism of vasodilatory epoxyeicosatrienoic acids (EETs), is sexually dimorphic, suppressed by estrogen, and contributes to underlying sex differences in cerebral blood flow and injury after cerebral ischemia.	eets	107-111	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
25377915-2	2015	Epoxyeicosatrienoic acids (EETs) are cytochrome P-450-dependent derivatives of arachidonic acid with antihypertensive, anti-inflammatory, and profibrinolytic functions.	eets	27-31	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	37-53
25377915-3	2015	We recently reported that genetic ablation of soluble epoxide hydrolase (sEH), an enzyme that converts EETs to less active dihydroxyeicosatrienoic acids, prevents renal tubulointerstitial fibrosis and inflammation in experimental mouse models of CKD.	eets	103-107	epoxide hydrolase 2, cytoplasmic	Mus musculus	46-71
25377915-3	2015	We recently reported that genetic ablation of soluble epoxide hydrolase (sEH), an enzyme that converts EETs to less active dihydroxyeicosatrienoic acids, prevents renal tubulointerstitial fibrosis and inflammation in experimental mouse models of CKD.	eets	103-107	epoxide hydrolase 2, cytoplasmic	Mus musculus	73-76
25642188-1	2014	Soluble epoxide hydrolase (sEH), a key enzyme in the metabolism of vasodilatory epoxyeicosatrienoic acids (EETs), is sexually dimorphic, suppressed by estrogen, and contributes to underlying sex differences in cerebral blood flow and injury after cerebral ischemia.	eets	107-111	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
25870948-2	2015	The cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert an anti-inflammatory effect on the cardiovascular system.	eets	104-108	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	4-35
26632190-1	2015	Arachidonic acid (AA) is metabolized to epoxyeicosatrienoic acids (EETs) via cytochrome enzymes such as CYP 2C9, 2C8 and 2J2.	eets	67-71	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	104-111
26632190-5	2015	In this study, we quantitatively investigated the inhibitory effects of ARBs on the formation of EETs and further metabolites, dihydroxyeicosatrienoic acids (DHETs), from AA via CYP2C8.	eets	97-101	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	178-184
26632190-6	2015	In incubations with recombinant CYP2C8 in vitro, the inhibitory effects were compared by measuring EETs and DHETs by HPLC-MS/MS.	eets	99-103	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	32-38
25870948-2	2015	The cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert an anti-inflammatory effect on the cardiovascular system.	eets	104-108	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	37-43
25406731-1	2014	BACKGROUND: Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid by cytochrome P450 (CYP) and metabolized by soluble epoxide hydrolase (sEH).	eets	39-43	epoxide hydrolase 2	Homo sapiens	123-148
25427230-1	2015	PURPOSE OF REVIEW: Cytochrome (CYP) P450 metabolites of arachidonic acid, 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) contribute to the regulation of renal tubular and vascular function.	eets	147-151	peptidylprolyl isomerase G	Homo sapiens	31-34
25055826-4	2014	Cytochrome P450 epoxygenases (Cyp4x1 and Cyp2c11) are expressed in the brain and vasculature and metabolize arachidonic acid (AA) to form epoxyeicosatrienoic acids (EETs).	eets	165-169	cytochrome P450, family 4, subfamily x, polypeptide 1	Rattus norvegicus	30-36
25055826-4	2014	Cytochrome P450 epoxygenases (Cyp4x1 and Cyp2c11) are expressed in the brain and vasculature and metabolize arachidonic acid (AA) to form epoxyeicosatrienoic acids (EETs).	eets	165-169	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	41-48
25677507-3	2015	Epoxyeicosatrienoic acids (EETs)-mediated up-regulation of heme oxygenase-1 (HO-1) protects against the detrimental consequences of MI in several animal models, however, the mechanism(s) by which this occurs remains unclear.	eets	27-31	heme oxygenase 1	Mus musculus	59-75
25677507-3	2015	Epoxyeicosatrienoic acids (EETs)-mediated up-regulation of heme oxygenase-1 (HO-1) protects against the detrimental consequences of MI in several animal models, however, the mechanism(s) by which this occurs remains unclear.	eets	27-31	heme oxygenase 1	Mus musculus	77-81
25406731-1	2014	BACKGROUND: Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid by cytochrome P450 (CYP) and metabolized by soluble epoxide hydrolase (sEH).	eets	39-43	epoxide hydrolase 2	Homo sapiens	150-153
25310404-2	2014	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which have potent anti-inflammatory effects.	eets	113-117	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-15
25372486-2	2014	Here we studied the modulation of intermediate-conductance Ca(2+)/calmodulin-regulated K(+) channels (K(Ca)3.1) by EETs, 20-HETE, omega3, and pentacyclic triterpenes and the structural requirements of these fatty acids to exert channel blockade.	eets	115-119	calmodulin 1	Homo sapiens	66-76
25372486-2	2014	Here we studied the modulation of intermediate-conductance Ca(2+)/calmodulin-regulated K(+) channels (K(Ca)3.1) by EETs, 20-HETE, omega3, and pentacyclic triterpenes and the structural requirements of these fatty acids to exert channel blockade.	eets	115-119	potassium calcium-activated channel subfamily N member 4	Homo sapiens	102-110
24882266-2	2014	The main human CYP epoxygenases, i.e. CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs).	eets	132-136	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	15-18
24882266-2	2014	The main human CYP epoxygenases, i.e. CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs).	eets	132-136	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	38-44
24882266-2	2014	The main human CYP epoxygenases, i.e. CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs).	eets	132-136	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	46-52
24882266-2	2014	The main human CYP epoxygenases, i.e. CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs).	eets	132-136	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	54-61
24882266-2	2014	The main human CYP epoxygenases, i.e. CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs).	eets	132-136	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	66-72
25426071-1	2014	Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid through cytochrome P450 (CYP) epoxygenases have many biological functions.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	73-88
25426071-1	2014	Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid through cytochrome P450 (CYP) epoxygenases have many biological functions.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	90-93
25310404-2	2014	Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which have potent anti-inflammatory effects.	eets	113-117	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	17-20
24966089-1	2014	Cytochrome P-450, family 2, subfamily c, polypeptide 44 (Cyp2c44) epoxygenase metabolizes arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs) in kidney and vascular tissues.	eets	142-146	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	0-55
25151892-1	2014	Previous studies have indicated that cytochrome P450 (CYP) metabolites of arachidonic acid (AA), i.e., 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), play an important role in the regulation of renal tubular and vascular function.	eets	176-180	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	37-52
25151892-1	2014	Previous studies have indicated that cytochrome P450 (CYP) metabolites of arachidonic acid (AA), i.e., 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), play an important role in the regulation of renal tubular and vascular function.	eets	176-180	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	54-57
25173047-1	2014	Epoxyeicosatrienoic acids (EETs) protect against the development of insulin resistance in rodents.	eets	27-31	insulin	Homo sapiens	68-75
25189712-1	2014	BACKGROUND: The cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) gene is expressed in the vascular endothelium, which metabolizes arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs).	eets	239-243	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	16-69
25189712-1	2014	BACKGROUND: The cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) gene is expressed in the vascular endothelium, which metabolizes arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs).	eets	239-243	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	71-77
25182955-1	2014	BACKGROUND: Cytochrome P450 (CYP) 2C9 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which have the crucial role in the modulation of cardiovascular homeostasis.	eets	162-166	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	12-37
24966089-1	2014	Cytochrome P-450, family 2, subfamily c, polypeptide 44 (Cyp2c44) epoxygenase metabolizes arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs) in kidney and vascular tissues.	eets	142-146	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	57-64
24691274-2	2014	The omega-3 epoxide of DHA, 19, 20-EDP (epoxy docosapentaenoic acid), is metabolized by soluble epoxide hydrolase (sEH), which also metabolizes the anti-inflammatory and antihypertensive arachidonic acid epoxides, epoxyeicosatrienoic acids (EETs).	eets	241-245	epoxide hydrolase 2	Homo sapiens	88-113
25024195-1	2014	Prostaglandins derived from the cyclooxygenase (COX) pathway and epoxyeicosatrienoic acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH) pathway are important eicosanoids that regulate angiogenesis and tumorigenesis.	eets	92-96	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	107-148
25024195-1	2014	Prostaglandins derived from the cyclooxygenase (COX) pathway and epoxyeicosatrienoic acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH) pathway are important eicosanoids that regulate angiogenesis and tumorigenesis.	eets	92-96	epoxide hydrolase 2	Homo sapiens	150-153
24691274-2	2014	The omega-3 epoxide of DHA, 19, 20-EDP (epoxy docosapentaenoic acid), is metabolized by soluble epoxide hydrolase (sEH), which also metabolizes the anti-inflammatory and antihypertensive arachidonic acid epoxides, epoxyeicosatrienoic acids (EETs).	eets	241-245	epoxide hydrolase 2	Homo sapiens	115-118
24824753-2	2014	sEH metabolizes neuroprotective epoxyeicosatrienoic acids (EETs).	eets	59-63	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
24917142-1	2014	PURPOSE: The purpose of this study was to investigate the role(s) of cytochrome P450 epoxygenases (CYPs) and their products, the epoxyeicosatrienoic acids (EETs), in hypoxia-induced VEGF production and pathologic retinal angiogenesis.	eets	156-160	vascular endothelial growth factor A	Homo sapiens	182-186
24510350-1	2014	Cytochrome P450 (CYP) 2C19 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which play a crucial role in either the detoxification or inactivation of potential carcinogens, or the bioactivation of some environmental procarcinogens to reactive DNA-binding metabolites.	eets	147-151	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-26
24530032-2	2014	However, EETs are biologically metabolized by soluble epoxide hydrolase (sEH) to less active metabolites.	eets	9-13	epoxide hydrolase 2	Rattus norvegicus	73-76
24486707-6	2014	Furthermore, the endothelial receptor of lectin-like oxidized low-density lipoprotein (LOX-1) was downregulated in PAECs treated with EETs.	eets	134-138	oxidized low density lipoprotein receptor 1	Rattus norvegicus	87-92
24154693-2	2013	Similarly, renal cytochrome P-450 (CYP)-epoxygenase-derived arachidonic acid metabolites, epoxyeicosatrienoic acids (EETs), also are antihypertensive through inhibiting sodium reabsorption and vasodilation.	eets	117-121	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	17-33
24471737-2	2014	The aim of the present study was to test the hypothesis that increasing kidney tissue concentrations of epoxyeicosatrienoic acids (EETs) by preventing their degradation to the biologically inactive dihydroxyeicosatrienoic acids (DHETEs) using blockade of soluble epoxide hydrolase (sEH) would attenuate the progression of chronic kidney disease (CKD).	eets	131-135	epoxide hydrolase 2	Rattus norvegicus	255-280
24471737-2	2014	The aim of the present study was to test the hypothesis that increasing kidney tissue concentrations of epoxyeicosatrienoic acids (EETs) by preventing their degradation to the biologically inactive dihydroxyeicosatrienoic acids (DHETEs) using blockade of soluble epoxide hydrolase (sEH) would attenuate the progression of chronic kidney disease (CKD).	eets	131-135	epoxide hydrolase 2	Rattus norvegicus	282-285
24040964-4	2014	Once formed, EETs are primarily metabolized to their less biologically active metabolites, dihydroxyeicosatrienoic acids, by soluble epoxy hydrolase (sEH) enzyme.	eets	13-17	epoxide hydrolase 2	Homo sapiens	125-148
24040964-4	2014	Once formed, EETs are primarily metabolized to their less biologically active metabolites, dihydroxyeicosatrienoic acids, by soluble epoxy hydrolase (sEH) enzyme.	eets	13-17	epoxide hydrolase 2	Homo sapiens	150-153
24903033-1	2014	BACKGROUND: Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acids to epoxyeicosatrienoic acids (EETs).	eets	113-117	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	12-43
24903033-1	2014	BACKGROUND: Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acids to epoxyeicosatrienoic acids (EETs).	eets	113-117	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	45-51
24285116-3	2014	In the present study, we explored the possible use of epoxyeicosatrienoic acids (EETs), epoxide metabolites of arachidonic acid, as therapeutic target against Abeta-induced mitochondrial impairment using cultured neonatal hippocampal astrocytes.	eets	81-85	amyloid beta precursor protein	Rattus norvegicus	159-164
24285116-9	2014	The uncoupling of ATP synthase from the electron transfer chain that occurred in Abeta-treated cells was also prevented by preincubation with EETs.	eets	142-146	amyloid beta precursor protein	Rattus norvegicus	81-86
25204827-2	2014	Located at the endoplasmic reticulum, CYP2J2 is responsible for epoxidation of endogenous arachidonic acid in cardiac tissue to produce cis-epoxyeicosatrienoic acids (EETs), which have anti-inflammatory and antifibrinolytic properties, and can protect endothelial cells from ischemic or hypoxic injuries.	eets	167-171	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	38-44
24154693-2	2013	Similarly, renal cytochrome P-450 (CYP)-epoxygenase-derived arachidonic acid metabolites, epoxyeicosatrienoic acids (EETs), also are antihypertensive through inhibiting sodium reabsorption and vasodilation.	eets	117-121	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	35-38
24324059-1	2013	Soluble epoxide hydrolase (sEH) hydrolyses/inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs) to their corresponding diols, and targeting sEH leads to strong anti-inflammatory effects.	eets	100-104	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
24324059-1	2013	Soluble epoxide hydrolase (sEH) hydrolyses/inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs) to their corresponding diols, and targeting sEH leads to strong anti-inflammatory effects.	eets	100-104	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
24324059-1	2013	Soluble epoxide hydrolase (sEH) hydrolyses/inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs) to their corresponding diols, and targeting sEH leads to strong anti-inflammatory effects.	eets	100-104	epoxide hydrolase 2, cytoplasmic	Mus musculus	150-153
23899929-3	2013	Soluble epoxide hydrolase (sEH) is a potential mediator of injury via its metabolism of neuroprotective epoxyeicosatrienoic acids (EETs).	eets	131-135	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
23474289-1	2013	Cytochrome p450 (CYP)2J2 is an epoxygenase enzyme that metabolises arachidonic acid to epoxyeicosatrienoic acids (EETs).	eets	114-118	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-24
24096258-2	2013	Cytochrome P450 (CYP450) eicosanoids derived from arachidonic acid include vasodilator epoxyeicosatrienoic acids (EETs) and the vasoconstrictor 20-hydroxyeicosatrienoic acid (20-HETE).	eets	114-118	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
24096258-2	2013	Cytochrome P450 (CYP450) eicosanoids derived from arachidonic acid include vasodilator epoxyeicosatrienoic acids (EETs) and the vasoconstrictor 20-hydroxyeicosatrienoic acid (20-HETE).	eets	114-118	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-23
23899929-3	2013	Soluble epoxide hydrolase (sEH) is a potential mediator of injury via its metabolism of neuroprotective epoxyeicosatrienoic acids (EETs).	eets	131-135	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
22517541-1	2013	Soluble epoxide hydrolase (sEH) quickly inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs) by converting them to dihydroxyeicosatrienoic acids (DHETs).	eets	97-101	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
23701967-2	2013	sEH readily hydrolyzes lipid signaling molecules, including the epoxyeicosatrienoic acids (EETs), epoxidized lipids produced from arachidonic acid by the action of cytochrome p450s.	eets	91-95	epoxide hydrolase 2	Homo sapiens	0-3
23729620-1	2013	Bradykinin causes vascular relaxations through release of endothelial relaxing factors including prostacyclin, nitric oxide (NO) and epoxyeicosatrienoic acids (EETs).	eets	160-164	kininogen 1	Bos taurus	0-10
22517541-1	2013	Soluble epoxide hydrolase (sEH) quickly inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs) by converting them to dihydroxyeicosatrienoic acids (DHETs).	eets	97-101	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
23792539-1	2013	Accumulating evidence suggests that soluble epoxide hydrolase (sEH) plays a key role in controlling levels of lipid signaling molecules, and that the potent sEH inhibitors may be potential therapeutic drugs for a number of diseases associated with metabolism of epoxyeicosatrienoic acids (EETs).	eets	289-293	epoxide hydrolase 2, cytoplasmic	Mus musculus	36-61
23792539-1	2013	Accumulating evidence suggests that soluble epoxide hydrolase (sEH) plays a key role in controlling levels of lipid signaling molecules, and that the potent sEH inhibitors may be potential therapeutic drugs for a number of diseases associated with metabolism of epoxyeicosatrienoic acids (EETs).	eets	289-293	epoxide hydrolase 2, cytoplasmic	Mus musculus	63-66
23792539-1	2013	Accumulating evidence suggests that soluble epoxide hydrolase (sEH) plays a key role in controlling levels of lipid signaling molecules, and that the potent sEH inhibitors may be potential therapeutic drugs for a number of diseases associated with metabolism of epoxyeicosatrienoic acids (EETs).	eets	289-293	epoxide hydrolase 2, cytoplasmic	Mus musculus	157-160
23684773-1	2013	BACKGROUND: Cytochrome P450 (CYP) 2J2 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs).	eets	162-166	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	12-37
22525341-1	2013	BACKGROUND: Epoxyeicosatrienoic acids (EETs) are natural angiogenic mediators regulated by soluble epoxide hydrolase (sEH).	eets	39-43	epoxide hydrolase 2	Homo sapiens	118-121
23967089-3	2013	Epoxyeicosatrienoic acids (EETs) are anti-inflammatory molecules synthesized by various cytochrome P450 (Cyp) enzymes from arachidonic acid.	eets	27-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	88-103
23967089-3	2013	Epoxyeicosatrienoic acids (EETs) are anti-inflammatory molecules synthesized by various cytochrome P450 (Cyp) enzymes from arachidonic acid.	eets	27-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	105-108
23967089-8	2013	Levels of Cyp2C2, Cyp2C6, and Cyp2J2, the principal Cyps responsible for EETs synthesis, as well as soluble epoxide hydrolase (sEH), which metabolizes EETS to DHETs, were determined via western blot.	eets	151-155	epoxide hydrolase 2	Rattus norvegicus	100-125
23967089-8	2013	Levels of Cyp2C2, Cyp2C6, and Cyp2J2, the principal Cyps responsible for EETs synthesis, as well as soluble epoxide hydrolase (sEH), which metabolizes EETS to DHETs, were determined via western blot.	eets	151-155	epoxide hydrolase 2	Rattus norvegicus	127-130
23766516-7	2013	With Acsl4 knockdown, incubation with 17 mm glucose increased media epoxyeicosatrienoic acids (EETs) and reduced cell membrane levels of EETs.	eets	95-99	acyl-CoA synthetase long-chain family member 4	Rattus norvegicus	5-10
23853671-3	2013	This review discusses the role of soluble epoxide hydrolase (sEH), an enzyme responsible for the degradation of vasoprotective eicosatrienoic acids (EETs), in the context of the cerebral vasculature and its contribution to the sexual dimorphic nature of stroke.	eets	149-153	epoxide hydrolase 2	Homo sapiens	34-59
23853671-3	2013	This review discusses the role of soluble epoxide hydrolase (sEH), an enzyme responsible for the degradation of vasoprotective eicosatrienoic acids (EETs), in the context of the cerebral vasculature and its contribution to the sexual dimorphic nature of stroke.	eets	149-153	epoxide hydrolase 2	Homo sapiens	61-64
23729436-2	2013	Epoxyeicosatrienoic acids (EETs), cytochrome P450 (P450) epoxygenase metabolites of arachidonic acid, play critical roles in regulation of blood pressure.	eets	27-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	34-68
23647230-2	2013	In cardiac tissues, CYP2J2 can adopt arachidonic acid as a major substrate to produce epoxyeicosatrienoic acids (EETs), which can protect endothelial cells from ischemic or hypoxic injuries and have been implicated in the pathogenesis of coronary artery disease and hypertension.	eets	113-117	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	20-26
23434473-1	2013	Soluble epoxide hydrolase (sEH, EPHX2) metabolizes eicosanoid epoxides, including epoxyeicosatrienoic acids (EETs) to the corresponding dihydroxyeicosatrienoic acids (DHETs), and leukotoxin (LTX) to leukotoxin diol (LTX diol).	eets	109-113	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
23434473-1	2013	Soluble epoxide hydrolase (sEH, EPHX2) metabolizes eicosanoid epoxides, including epoxyeicosatrienoic acids (EETs) to the corresponding dihydroxyeicosatrienoic acids (DHETs), and leukotoxin (LTX) to leukotoxin diol (LTX diol).	eets	109-113	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
23434473-1	2013	Soluble epoxide hydrolase (sEH, EPHX2) metabolizes eicosanoid epoxides, including epoxyeicosatrienoic acids (EETs) to the corresponding dihydroxyeicosatrienoic acids (DHETs), and leukotoxin (LTX) to leukotoxin diol (LTX diol).	eets	109-113	epoxide hydrolase 2, cytoplasmic	Mus musculus	32-37
22922020-1	2013	Cardioprotective effects of epoxyeicosatrienoic acids (EETs) have been demonstrated in models of young mice with either the cardiomyocyte specific over-expression of cytochrome P450 2J2 (CYP2J2 Tr) or deletion of soluble epoxide hydrolase (sEH null).	eets	55-59	epoxide hydrolase 2, cytoplasmic	Mus musculus	213-238
22922020-1	2013	Cardioprotective effects of epoxyeicosatrienoic acids (EETs) have been demonstrated in models of young mice with either the cardiomyocyte specific over-expression of cytochrome P450 2J2 (CYP2J2 Tr) or deletion of soluble epoxide hydrolase (sEH null).	eets	55-59	epoxide hydrolase 2, cytoplasmic	Mus musculus	240-243
23307303-9	2013	CONCLUSION: Our current findings indicate that the antihypertensive actions of sEH inhibition in this ANG II-dependent malignant form of hypertension are dependent on the interactions of endogenous bioavailability of EETs and NO.	eets	217-221	epoxide hydrolase 2	Rattus norvegicus	79-82
24216999-2	2013	Cytochrome P450 (CYP) activity and synthesis of both epoxyeicosatrienoic acids (EETs) and 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), together with vascular endothelial growth factor (VEGF) and heme oxygenase system (HO) have emerged as important modulators of tumor growth and metastasis.	eets	80-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
24216999-2	2013	Cytochrome P450 (CYP) activity and synthesis of both epoxyeicosatrienoic acids (EETs) and 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), together with vascular endothelial growth factor (VEGF) and heme oxygenase system (HO) have emerged as important modulators of tumor growth and metastasis.	eets	80-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
23619744-8	2013	Surprisingly, the CYP metabolites of AA, epoxyeicosatrienoic acids (EETs), were much less potent activators of TRPV4, and CYP inhibitors did not affect EET production in HCAECs.	eets	68-72	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	18-21
23039246-1	2013	The aim of the present study was to evaluate the hypothesis that the antihypertensive effects of inhibition of soluble epoxide hydrolase (sEH) are mediated by increased intrarenal availability of epoxyeicosatrienoic acids (EETs), with consequent improvement in renal haemodynamic autoregulatory efficiency and the pressure-natriuresis relationship.	eets	223-227	epoxide hydrolase 2	Rattus norvegicus	111-136
23039246-1	2013	The aim of the present study was to evaluate the hypothesis that the antihypertensive effects of inhibition of soluble epoxide hydrolase (sEH) are mediated by increased intrarenal availability of epoxyeicosatrienoic acids (EETs), with consequent improvement in renal haemodynamic autoregulatory efficiency and the pressure-natriuresis relationship.	eets	223-227	epoxide hydrolase 2	Rattus norvegicus	138-141
23283969-0	2013	Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation.	eets	27-31	mitogen-activated protein kinase 1	Homo sapiens	80-121
23283969-0	2013	Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation.	eets	27-31	mitogen-activated protein kinase 3	Homo sapiens	123-129
23283969-2	2013	Roles for the arachidonic acid epoxygenase metabolites, the epoxyeicosatrienoic acids (EETs), in ENaC activity have been identified; however, their mechanisms of action remain unknown.	eets	87-91	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	14-42
23160182-5	2013	To verify specificity, we demonstrated that the CYP and sEH products epoxyeiscosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids (DHETs), respectively, restored chemotaxis in the presence of the inhibitors, indicating that sEH-derived products are essential for MCP-1-driven chemotaxis.	eets	97-101	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	48-51
23160182-5	2013	To verify specificity, we demonstrated that the CYP and sEH products epoxyeiscosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids (DHETs), respectively, restored chemotaxis in the presence of the inhibitors, indicating that sEH-derived products are essential for MCP-1-driven chemotaxis.	eets	97-101	epoxide hydrolase 2, cytoplasmic	Mus musculus	56-59
23160182-5	2013	To verify specificity, we demonstrated that the CYP and sEH products epoxyeiscosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids (DHETs), respectively, restored chemotaxis in the presence of the inhibitors, indicating that sEH-derived products are essential for MCP-1-driven chemotaxis.	eets	97-101	epoxide hydrolase 2, cytoplasmic	Mus musculus	231-234
23160182-5	2013	To verify specificity, we demonstrated that the CYP and sEH products epoxyeiscosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids (DHETs), respectively, restored chemotaxis in the presence of the inhibitors, indicating that sEH-derived products are essential for MCP-1-driven chemotaxis.	eets	97-101	chemokine (C-C motif) ligand 2	Mus musculus	270-275
23122666-1	2013	BACKGROUND: Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess angiogenic effects.	eets	69-73	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	12-27
23122666-1	2013	BACKGROUND: Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess angiogenic effects.	eets	69-73	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	29-32
23307303-9	2013	CONCLUSION: Our current findings indicate that the antihypertensive actions of sEH inhibition in this ANG II-dependent malignant form of hypertension are dependent on the interactions of endogenous bioavailability of EETs and NO.	eets	217-221	angiotensinogen	Rattus norvegicus	102-108
23020295-1	2013	The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by soluble epoxide hydrolase (sEH) to 1,2-diols were first reported 30 years ago.	eets	43-47	epoxide hydrolase 2	Homo sapiens	84-109
23237835-2	2013	The inhibition of soluble epoxide hydrolase leads to elevated levels of epoxyeicosatrienoic acids (EETs), and thus inhibitors of sEH represent one of a novel approach to the development of vasodilatory and anti-inflammatory drugs.	eets	99-103	epoxide hydrolase 2	Homo sapiens	18-43
23237835-2	2013	The inhibition of soluble epoxide hydrolase leads to elevated levels of epoxyeicosatrienoic acids (EETs), and thus inhibitors of sEH represent one of a novel approach to the development of vasodilatory and anti-inflammatory drugs.	eets	99-103	epoxide hydrolase 2	Homo sapiens	129-132
21912424-1	2013	The omega-hydroxylase CYP4A11 catalyzes the transformation of epoxyeicosatrienoic acids (EETs) to omega-hydroxylated EETs, endogenous peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists.	eets	89-93	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	22-29
21912424-1	2013	The omega-hydroxylase CYP4A11 catalyzes the transformation of epoxyeicosatrienoic acids (EETs) to omega-hydroxylated EETs, endogenous peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists.	eets	89-93	peroxisome proliferator activated receptor alpha	Homo sapiens	134-182
21912424-1	2013	The omega-hydroxylase CYP4A11 catalyzes the transformation of epoxyeicosatrienoic acids (EETs) to omega-hydroxylated EETs, endogenous peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists.	eets	89-93	peroxisome proliferator activated receptor alpha	Homo sapiens	184-193
23020295-1	2013	The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by soluble epoxide hydrolase (sEH) to 1,2-diols were first reported 30 years ago.	eets	43-47	epoxide hydrolase 2	Homo sapiens	111-114
22865388-2	2012	Recent data have shown that pharmacological inhibition of soluble epoxide hydrolase (sEH), an enzyme that decreases the endogenous levels of protective epoxyeicosatrienoic acids (EETs), improves glucose homeostasis in insulin-resistant mice.	eets	179-183	epoxide hydrolase 2, cytoplasmic	Mus musculus	58-83
22865388-2	2012	Recent data have shown that pharmacological inhibition of soluble epoxide hydrolase (sEH), an enzyme that decreases the endogenous levels of protective epoxyeicosatrienoic acids (EETs), improves glucose homeostasis in insulin-resistant mice.	eets	179-183	epoxide hydrolase 2, cytoplasmic	Mus musculus	85-88
22621785-3	2012	Epoxyeicosatrienoic acids (EETs), products of cytochrome P-450 epoxidation of arachidonic acid, have vasculoprotective and anti-inflammatory effects including inhibition of platelet activation, cell migration, and adhesion.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	46-62
22588244-1	2012	BACKGROUND: Soluble epoxide hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids (EETs) into their much less active dihydroxy derivatives dihydroxyeicosatrienoic acids.	eets	101-105	epoxide hydrolase 2, cytoplasmic	Mus musculus	12-37
22588244-1	2012	BACKGROUND: Soluble epoxide hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids (EETs) into their much less active dihydroxy derivatives dihydroxyeicosatrienoic acids.	eets	101-105	epoxide hydrolase 2, cytoplasmic	Mus musculus	39-42
22664166-8	2012	Moreover, we report a novel inhibitory mechanism because TGA stimulates the production of an anti-inflammatory P-450 eicosanoid metabolites (cis-epoxyeicosatrienoic acids [EETs]) in the lung.	eets	172-176	T-box transcription factor 1	Homo sapiens	57-60
22641086-4	2012	sEH contributes to neuronal cell death by inactivating neuroprotective epoxyeicosatrienoic acids (EETs).	eets	98-102	epoxide hydrolase 2	Homo sapiens	0-3
22260463-1	2012	The cytochrome P450 epoxygenase, CYP2J2, converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs), which are highly abundant in the kidney and considered renoprotective.	eets	116-120	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	33-39
22173545-2	2012	Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as candidate mediators in the development of hypertension in several animal models, with remarkable sex-specific effect.	eets	97-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
22173545-2	2012	Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as candidate mediators in the development of hypertension in several animal models, with remarkable sex-specific effect.	eets	97-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
22155000-1	2012	Epoxyeicosatrienoic acids (EETs), cytochrome P450-derived metabolites of arachidonic acid, are endogenously produced epoxides that act as substrates for the soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	157-182
22624559-1	2012	Epoxyeicosatrienoic acids (EETs) are active metabolites of arachidonic acid that are inactivated by soluble epoxide hydrolase enzyme (sEH) to dihydroxyeicosatrienoic acid.	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	100-132
22624559-1	2012	Epoxyeicosatrienoic acids (EETs) are active metabolites of arachidonic acid that are inactivated by soluble epoxide hydrolase enzyme (sEH) to dihydroxyeicosatrienoic acid.	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	134-137
22155238-1	2012	The study addressed the hypothesis that soluble epoxide hydrolase (sEH) inhibition, which increases cardiovascular protective epoxyeicosatrienoic acids (EETs), exerts beneficial effects in an established chronic heart failure (CHF) model.	eets	153-157	epoxide hydrolase 2	Rattus norvegicus	40-65
22155238-1	2012	The study addressed the hypothesis that soluble epoxide hydrolase (sEH) inhibition, which increases cardiovascular protective epoxyeicosatrienoic acids (EETs), exerts beneficial effects in an established chronic heart failure (CHF) model.	eets	153-157	epoxide hydrolase 2	Rattus norvegicus	67-70
22414856-2	2012	Epoxyeicosatrienoic acids (EETs) are anti-inflammatory cytochrome P450-derived eicosanoids that are abundantly produced in the kidney and metabolized by soluble epoxide hydrolase (sEH; Ephx2) to less active dihydroxyeicosatrienoic acids.	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	153-178
22414856-2	2012	Epoxyeicosatrienoic acids (EETs) are anti-inflammatory cytochrome P450-derived eicosanoids that are abundantly produced in the kidney and metabolized by soluble epoxide hydrolase (sEH; Ephx2) to less active dihydroxyeicosatrienoic acids.	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	180-183
22414856-2	2012	Epoxyeicosatrienoic acids (EETs) are anti-inflammatory cytochrome P450-derived eicosanoids that are abundantly produced in the kidney and metabolized by soluble epoxide hydrolase (sEH; Ephx2) to less active dihydroxyeicosatrienoic acids.	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	185-190
22365750-12	2012	PON1, in vitro, metabolized 5,6-EET, but not other EETs, to its corresponding diol.	eets	51-55	paraoxonase 1	Mus musculus	0-4
22155000-1	2012	Epoxyeicosatrienoic acids (EETs), cytochrome P450-derived metabolites of arachidonic acid, are endogenously produced epoxides that act as substrates for the soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	184-187
22848834-1	2012	Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs).	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-118
22072631-2	2012	The role of sEH hydrolase activity in the metabolism of epoxyeicosatrienoic acids (EETs) and the activation of endothelial nitric oxide synthase (eNOS) in endothelial cells (ECs) has been well defined.	eets	83-87	epoxide hydrolase 2, cytoplasmic	Mus musculus	12-15
22415079-0	2012	Heme oxygenase (HO-1) rescue of adipocyte dysfunction in HO-2 deficient mice via recruitment of epoxyeicosatrienoic acids (EETs) and adiponectin.	eets	123-127	heme oxygenase 1	Mus musculus	16-20
22415079-0	2012	Heme oxygenase (HO-1) rescue of adipocyte dysfunction in HO-2 deficient mice via recruitment of epoxyeicosatrienoic acids (EETs) and adiponectin.	eets	123-127	heme oxygenase 2	Mus musculus	57-61
22975950-1	2012	Epoxyeicosatrienoic acids (EETs) produced by cytochrome P450 (CYP)-dependent epoxidation of arachidonic acid (AA) inhibit thrombocyte adhesion to the vascular wall.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	45-60
22975950-1	2012	Epoxyeicosatrienoic acids (EETs) produced by cytochrome P450 (CYP)-dependent epoxidation of arachidonic acid (AA) inhibit thrombocyte adhesion to the vascular wall.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	62-65
22848834-1	2012	Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs).	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	120-123
22848834-1	2012	Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs).	eets	27-31	epoxide hydrolase 2	Homo sapiens	180-205
22848834-1	2012	Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs).	eets	27-31	epoxide hydrolase 2	Homo sapiens	207-210
22182836-1	2012	Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	68-83
22182836-1	2012	Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	85-88
21843605-6	2011	EETs are rapidly degraded into dihydroxyeicosatrienoic acids (DiHETEs) by soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2	Rattus norvegicus	74-99
22189162-1	2011	Accumulating evidence suggests that cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs) which play important roles in various pathophysiological processes.	eets	131-135	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	36-51
22189162-1	2011	Accumulating evidence suggests that cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs) which play important roles in various pathophysiological processes.	eets	131-135	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	53-56
22590647-1	2012	Soluble epoxide hydrolase (sEH) in endothelial cells determines the plasma concentrations of epoxyeicosatrienoic acids (EETs), which may act as vasoactive agents to control vascular tone.	eets	120-124	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
22590647-1	2012	Soluble epoxide hydrolase (sEH) in endothelial cells determines the plasma concentrations of epoxyeicosatrienoic acids (EETs), which may act as vasoactive agents to control vascular tone.	eets	120-124	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
22313298-2	2011	Inhibition of sEH by a highly selective and potent sEH inhibitor (sEHI) elevates the epoxyeicosatrienoic acids (EETs) level in vivo leading to decreased inflammation.	eets	112-116	epoxide hydrolase 2	Homo sapiens	14-17
22313298-2	2011	Inhibition of sEH by a highly selective and potent sEH inhibitor (sEHI) elevates the epoxyeicosatrienoic acids (EETs) level in vivo leading to decreased inflammation.	eets	112-116	epoxide hydrolase 2	Homo sapiens	51-54
21843605-6	2011	EETs are rapidly degraded into dihydroxyeicosatrienoic acids (DiHETEs) by soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2	Rattus norvegicus	101-104
21843605-9	2011	When we separated the cerebrum into cortex and hippocampus, significant decrease in the production of total EETs and DiHETEs were seen in presence of Abeta (81% and 74%) in the cortex.	eets	108-112	amyloid beta precursor protein	Rattus norvegicus	150-155
21753077-1	2011	Cytochrome P-450 metabolites of arachidonic acid, the epoxyeicosatrienoic acids (EETs) and hydrogen peroxide (H(2)O(2)), are important signaling molecules in the kidney.	eets	81-85	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
21519968-1	2011	INTRODUCTION: Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs), which in turn are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	eets	101-105	epoxide hydrolase 2	Homo sapiens	180-205
21519968-1	2011	INTRODUCTION: Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs), which in turn are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	eets	101-105	epoxide hydrolase 2	Homo sapiens	207-210
21519968-8	2011	In contrast, inhibition of phosphodiesterase IV (PDE4) with rolipram eliminated the effects of EETs or DHETs, and inhibition of Galphai with pertussis toxin also resulted in enhanced cAMP production.	eets	95-99	phosphodiesterase 4A	Homo sapiens	49-53
21697548-1	2011	Cytochrome P450 (CYP) epoxygenases CYP2C8 and CYP2J2 generate epoxyeicosatrienoic acids (EETs) from arachidonic acid.	eets	89-93	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	35-41
21411763-2	2011	A previous study indicated that bioavailability of cytochrome P-450 metabolites epoxyeicosatrienoic acids (EETs) is decreased while that of 20-hydroxyeicosatetraenoic acids (20-HETE) is increased in this model.	eets	107-111	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	51-67
21757024-6	2011	A recent publication has demonstrated that stabilizing the levels of epoxyeicosatrienoic acids (EETs), CYP eicosanoids, by inhibiting or deleting soluble epoxide hydrolase (sEH) improves beta-cell function and reduces beta-cell apoptosis in diabetes.	eets	96-100	epoxide hydrolase 2	Homo sapiens	146-171
21757024-6	2011	A recent publication has demonstrated that stabilizing the levels of epoxyeicosatrienoic acids (EETs), CYP eicosanoids, by inhibiting or deleting soluble epoxide hydrolase (sEH) improves beta-cell function and reduces beta-cell apoptosis in diabetes.	eets	96-100	epoxide hydrolase 2	Homo sapiens	173-176
21683067-2	2011	Epoxyeicosatrienoic acids (EETs) are cytochrome P-450 metabolites of arachidonic acid reported to have multiple biological functions, including blocking of leukocyte recruitment to inflamed endothelium in cell culture through reduction of adhesion molecule expression.	eets	27-31	uncharacterized protein LOC107819388	Nicotiana tabacum	37-53
21476972-6	2011	CYP isoforms expressed in the heart are critical for generation of epoxyeicosatrienoic acids (EETs) and ROS.	eets	94-98	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
21451419-1	2011	OBJECTIVES: The study addresses the hypothesis that endothelial dysfunction in experimental arterial hypertension can be related to an alteration in epoxyeicosatrienoic acids (EETs) pathway and can be prevented by the inhibition of EETs degradation by soluble epoxide hydrolase (sEH).	eets	176-180	epoxide hydrolase 2, cytoplasmic	Mus musculus	252-277
21332417-1	2011	OBJECTIVES: Cytochrome P450 (CYP) 2C19 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which play a centralrole in regulating renal tubular fluid-electrolyte transport and vascular tone.	eets	159-163	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	12-38
21451419-1	2011	OBJECTIVES: The study addresses the hypothesis that endothelial dysfunction in experimental arterial hypertension can be related to an alteration in epoxyeicosatrienoic acids (EETs) pathway and can be prevented by the inhibition of EETs degradation by soluble epoxide hydrolase (sEH).	eets	176-180	epoxide hydrolase 2, cytoplasmic	Mus musculus	279-282
21155804-1	2011	It has recently been reported that soluble epoxide hydrolase (sEH), the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), is expressed in axons of cortical neurons; however, the functional relevance of axonal sEH localization is unknown.	eets	129-133	epoxide hydrolase 2	Homo sapiens	35-60
21155804-1	2011	It has recently been reported that soluble epoxide hydrolase (sEH), the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), is expressed in axons of cortical neurons; however, the functional relevance of axonal sEH localization is unknown.	eets	129-133	epoxide hydrolase 2	Homo sapiens	62-65
21155804-1	2011	It has recently been reported that soluble epoxide hydrolase (sEH), the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), is expressed in axons of cortical neurons; however, the functional relevance of axonal sEH localization is unknown.	eets	129-133	epoxide hydrolase 2	Homo sapiens	223-226
20433684-4	2011	Soluble epoxide hydrolase (sEH) is an enzyme that catalyzes the hydrolysis of epoxyeicosatrienoic acids (EETs), which are lipid mediators derived from arachidonic acid through the cytochrome P450 epoxygenase pathway.	eets	105-109	epoxide hydrolase 2	Homo sapiens	0-25
20433684-4	2011	Soluble epoxide hydrolase (sEH) is an enzyme that catalyzes the hydrolysis of epoxyeicosatrienoic acids (EETs), which are lipid mediators derived from arachidonic acid through the cytochrome P450 epoxygenase pathway.	eets	105-109	epoxide hydrolase 2	Homo sapiens	27-30
20433684-6	2011	When EETs are hydrolyzed by sEH to corresponding dihydroxyeicosatrienoic acids, their cardioprotective activities become less pronounced.	eets	5-9	epoxide hydrolase 2	Homo sapiens	28-31
21059750-1	2011	Cytochrome P-450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess potent anti-inflammatory effects in vitro.	eets	58-62	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-16
21356152-1	2011	The eicosanoids 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), which are generated from the metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes, possess a wide array of biological actions, including the regulation of blood flow to organs.	eets	89-93	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	159-174
21356152-1	2011	The eicosanoids 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), which are generated from the metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes, possess a wide array of biological actions, including the regulation of blood flow to organs.	eets	89-93	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	176-179
21039415-1	2011	BACKGROUND AND PURPOSE: Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase metabolites of arachidonic acid that are metabolized into dihydroxyepoxyeicosatrienoic acids (DHET) by soluble epoxide hydrolase (sEH).	eets	51-55	epoxide hydrolase 2	Rattus norvegicus	192-217
21039415-1	2011	BACKGROUND AND PURPOSE: Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase metabolites of arachidonic acid that are metabolized into dihydroxyepoxyeicosatrienoic acids (DHET) by soluble epoxide hydrolase (sEH).	eets	51-55	epoxide hydrolase 2	Rattus norvegicus	219-222
21077851-3	2011	Thus, omega-6 arachidonic acid epoxides (EETs) inhibit apoptosis and stimulate proliferation by up-regulating cyclin D1 expression in cells.	eets	41-45	cyclin D1	Mus musculus	110-119
21059750-1	2011	Cytochrome P-450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess potent anti-inflammatory effects in vitro.	eets	58-62	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	18-21
21566342-7	2011	Previously, we showed that CYP3A4 can produce epoxyeicosatrienoic acids (EETs) from arachidonic acid.	eets	73-77	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	27-33
21030485-1	2011	Cytochrome P450 2J2 (CYP2J2) epoxygenase converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs) that exert multiple biological effects in the cardiovascular system and in various human solid cancers.	eets	116-120	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-19
21030485-1	2011	Cytochrome P450 2J2 (CYP2J2) epoxygenase converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs) that exert multiple biological effects in the cardiovascular system and in various human solid cancers.	eets	116-120	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	21-27
20732876-4	2010	CYP2C/2J isoforms converting AA to epoxyeicosatrienoic acids (EETs) preferentially epoxidized the omega-3 double bond and thereby produced 17,18-epoxyeicosatetraenoic (17,18-EEQ) and 19,20-epoxydocosapentaenoic acid (19,20-EDP) from EPA and DHA.	eets	62-66	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	0-7
20378604-2	2010	The CYP-mediated epoxyeicosatrienoates (EETs) have been described previously as the predominant eicosanoids in human lungs upon stimulation with the Ca(2+) ionophore A23187.	eets	40-44	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-7
20460345-1	2010	OBJECTIVES: Cytochrome P450 (CYP) 2C19 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which are potent endogenous vasodilators and inhibitors of vascular inflammation.	eets	159-163	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	12-38
20495177-1	2010	Renal cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) regulate sodium transport and blood pressure.	eets	63-67	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	6-21
20495177-1	2010	Renal cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) regulate sodium transport and blood pressure.	eets	63-67	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	23-26
20733953-3	2010	Soluble epoxide hydrolase (sEH) is an enzyme that converts endogenous anti-inflammatory compounds, the epoxyeicosatrienoic acids (EETs), to the less anti-inflammatory dihydroxyeicosatrienoic acids (DHETs).	eets	130-134	epoxide hydrolase 2	Homo sapiens	0-25
20493836-1	2010	Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) catalyzed by cytochrome P450 (CYP), have many essential biologic roles in the cardiovascular system including inhibition of apoptosis in cardiomyocytes.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	84-99
20493836-1	2010	Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) catalyzed by cytochrome P450 (CYP), have many essential biologic roles in the cardiovascular system including inhibition of apoptosis in cardiomyocytes.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	101-104
21416942-2	2010	Epoxyeicosatrienoic acids (EETs), as metabolites of arachidonic acid, are degraded by sEH.	eets	27-31	epoxide hydrolase 2	Homo sapiens	86-89
20733953-3	2010	Soluble epoxide hydrolase (sEH) is an enzyme that converts endogenous anti-inflammatory compounds, the epoxyeicosatrienoic acids (EETs), to the less anti-inflammatory dihydroxyeicosatrienoic acids (DHETs).	eets	130-134	epoxide hydrolase 2	Homo sapiens	27-30
20140850-1	2010	BACKGROUND: Cytochrome P450 (CYP) 2J2 is a regulatory enzyme in the biosynthesis of biologically active CIS-epoxyeicosatrienoic acids (EETs).	eets	135-139	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	12-37
20045729-1	2010	Cytochrome P450 (CYP) generated cardioprotective metabolites, epoxyeicosatrienoic acids (EETs), and cardiotoxic metabolites, hydroxyeicosatetraenoic acids (HETEs) levels are determined by many factors, including the induction or repression of the CYP enzymes, responsible for their formation.	eets	89-93	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
20045729-1	2010	Cytochrome P450 (CYP) generated cardioprotective metabolites, epoxyeicosatrienoic acids (EETs), and cardiotoxic metabolites, hydroxyeicosatetraenoic acids (HETEs) levels are determined by many factors, including the induction or repression of the CYP enzymes, responsible for their formation.	eets	89-93	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	17-20
19896470-3	2010	Inhibition of sEH stabilizes the cytochrome P450 (CYP450) products epoxyeicosatrienoic acids (EETs).	eets	94-98	epoxide hydrolase 2, cytoplasmic	Mus musculus	14-17
20224870-1	2010	Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced by the vascular endothelium in response to agonists such as bradykinin and acetylcholine or physical stimuli such as shear stress or cyclic stretch.	eets	27-31	kininogen 1	Homo sapiens	163-173
20008276-1	2010	Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs), primarily 14,15-EET.	eets	71-75	epoxide hydrolase 2	Homo sapiens	0-25
20093140-4	2010	CYP epoxygenases such as CYP1A2, CYP2C, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which generally possess vasodilating, anti-inflammatory, anti-apoptotic, anti-thrombotic, natriuretic, and cardioprotective effects.	eets	109-113	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	25-31
20093140-4	2010	CYP epoxygenases such as CYP1A2, CYP2C, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which generally possess vasodilating, anti-inflammatory, anti-apoptotic, anti-thrombotic, natriuretic, and cardioprotective effects.	eets	109-113	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	33-38
20093140-4	2010	CYP epoxygenases such as CYP1A2, CYP2C, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which generally possess vasodilating, anti-inflammatory, anti-apoptotic, anti-thrombotic, natriuretic, and cardioprotective effects.	eets	109-113	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	44-50
20008276-1	2010	Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs), primarily 14,15-EET.	eets	71-75	epoxide hydrolase 2	Homo sapiens	27-30
19679679-1	2010	AIMS: The C-terminal domain of the soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity.	eets	106-110	epoxide hydrolase 2, cytoplasmic	Mus musculus	35-60
19891972-1	2010	The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	eets	137-141	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-19
19891972-1	2010	The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	eets	137-141	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-24
19891972-1	2010	The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	eets	137-141	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	56-61
21081214-1	2010	Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced by the vascular endothelium in responses to various stimuli such as the agonists acetylcholine (ACH) or bradykinin or by shear stress which activates phospholipase A(2) to release arachidonic acid.	eets	27-31	kininogen 1	Homo sapiens	207-217
19679679-1	2010	AIMS: The C-terminal domain of the soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity.	eets	106-110	epoxide hydrolase 2, cytoplasmic	Mus musculus	62-65
19944311-2	2009	Cytochrome P-450 (CYP) 2J2 that is expressed in endothelial cells metabolizes arachidonic acids to biologically active epoxyeicosatrienoic acids (EETs) that possess anti-inflammatory and anti-thrombotic effects.	eets	146-150	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-26
19889059-10	2009	Both 3-MC and BaP treatments increased the dihydroxyeicosatrienoic acids (DHETs) : epoxyeicosatrienoic acids (EETs) ratio and the 20-hydroxyeicosatetraenoic acid (20-HETE) : total EETs ratio.	eets	110-114	prohibitin 2	Rattus norvegicus	14-17
19889059-10	2009	Both 3-MC and BaP treatments increased the dihydroxyeicosatrienoic acids (DHETs) : epoxyeicosatrienoic acids (EETs) ratio and the 20-hydroxyeicosatetraenoic acid (20-HETE) : total EETs ratio.	eets	180-184	prohibitin 2	Rattus norvegicus	14-17
19952412-1	2009	Soluble epoxide hydrolase (sEH) is an important pharmacological target because it metabolizes potent bioactive substrates, epoxyeicosatrienoinc acids (EETs) and other lipid epoxide.	eets	151-155	epoxide hydrolase 2	Homo sapiens	0-25
19952412-1	2009	Soluble epoxide hydrolase (sEH) is an important pharmacological target because it metabolizes potent bioactive substrates, epoxyeicosatrienoinc acids (EETs) and other lipid epoxide.	eets	151-155	epoxide hydrolase 2	Homo sapiens	27-30
19716829-3	2009	sEH catalizes the conversion of epoxyeicosatrienoic acids (EETs) to form the corresponding dihydroxyeicosatrienoic acids (DHETs).	eets	59-63	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
19458064-2	2009	sEH converts epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), and the phosphatase activity is suggested to be involved in cholesterol metabolism.	eets	40-44	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
19643090-1	2009	Soluble epoxide hydrolase (sEH) is the major enzyme responsible for the metabolism and inactivation of epoxyeicosatrienoic acids (EETs).	eets	130-134	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
19643090-1	2009	Soluble epoxide hydrolase (sEH) is the major enzyme responsible for the metabolism and inactivation of epoxyeicosatrienoic acids (EETs).	eets	130-134	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
19549792-1	2009	Cytochrome P-450 (CYP450) enzymes of the CYP2 and -4 family in humans metabolize arachidonic acid to generate bioactive epoxyeicosatrienenoic acids (EETs) and hydroxyeicosatetrenoic acids (HETEs).	eets	149-153	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
19549792-1	2009	Cytochrome P-450 (CYP450) enzymes of the CYP2 and -4 family in humans metabolize arachidonic acid to generate bioactive epoxyeicosatrienenoic acids (EETs) and hydroxyeicosatetrenoic acids (HETEs).	eets	149-153	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	18-24
18973759-1	2009	Cytochrome P450 epoxygenases metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs) which are in turn converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	eets	92-96	epoxide hydrolase 2, cytoplasmic	Mus musculus	170-195
19471280-1	2009	Soluble epoxide hydrolase (sEH), a key enzyme in the metabolism of vasodilator eicosanoids called epoxyeicosatrienoic acids (EETs), is sexually dimorphic and suppressed by estrogen.	eets	125-129	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
19471280-1	2009	Soluble epoxide hydrolase (sEH), a key enzyme in the metabolism of vasodilator eicosanoids called epoxyeicosatrienoic acids (EETs), is sexually dimorphic and suppressed by estrogen.	eets	125-129	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
19285984-1	2009	Epoxyeicosatrienoic acids (EETs) are polyunsaturated fatty acids synthesized from arachidonic acid by CYP2J2 epoxygenase and inactivated by soluble epoxide hydrolase (sEH or Ephx2) to dihydroxyeicosatrienoic acids.	eets	27-31	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	102-108
19285984-1	2009	Epoxyeicosatrienoic acids (EETs) are polyunsaturated fatty acids synthesized from arachidonic acid by CYP2J2 epoxygenase and inactivated by soluble epoxide hydrolase (sEH or Ephx2) to dihydroxyeicosatrienoic acids.	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	167-170
19285984-1	2009	Epoxyeicosatrienoic acids (EETs) are polyunsaturated fatty acids synthesized from arachidonic acid by CYP2J2 epoxygenase and inactivated by soluble epoxide hydrolase (sEH or Ephx2) to dihydroxyeicosatrienoic acids.	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	174-179
19289568-1	2009	The cytochrome P450 epoxygenase, CYP2J2, converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs).	eets	116-120	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	33-39
19304946-1	2009	Epoxyeicosatrienoic acids (EETs) are potent vasodilators produced from arachidonic acid by cytochrome P-450 (CYP) epoxygenases and metabolized to vicinal diols by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	163-188
19304946-1	2009	Epoxyeicosatrienoic acids (EETs) are potent vasodilators produced from arachidonic acid by cytochrome P-450 (CYP) epoxygenases and metabolized to vicinal diols by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	190-193
19779591-1	2009	Soluble epoxide hydrolase (sEH) is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs).	eets	146-150	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
19779591-1	2009	Soluble epoxide hydrolase (sEH) is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs).	eets	146-150	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
19226702-1	2009	OBJECTIVES: The soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to their less active dihydroxy derivatives.	eets	87-91	epoxide hydrolase 2	Rattus norvegicus	16-41
19226702-1	2009	OBJECTIVES: The soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to their less active dihydroxy derivatives.	eets	87-91	epoxide hydrolase 2	Rattus norvegicus	43-46
19226702-5	2009	sEH inhibition increased the plasma ratio of EETs to DHETs and attenuated the monocrotaline-induced increase in pulmonary artery medial wall thickness as well as the degree of vascular muscularization.	eets	45-49	epoxide hydrolase 2	Rattus norvegicus	0-3
19226702-8	2009	sEH inhibitors, however, increased the plasma ratio of EETs to dihydroxy epoxyeicosatrienoic acids.	eets	55-59	epoxide hydrolase 2	Rattus norvegicus	0-3
19505190-1	2009	BACKGROUND: CYP enzymes from the CYP2C and CYP2J subfamilies metabolize arachidonic acid in a regiospecific and stereoselective manner to eight epoxyeicosatrienoic acids (EETs).	eets	171-175	peptidylprolyl isomerase G	Homo sapiens	12-15
19333883-3	2009	Cardioprotective effects were also achieved when metabolism of the endogenous epoxyeicosatrienoic acids (EETs) by their major enzymatic hydrolysis pathway was blocked in gene knockout mice (EPHX2-/-) or by inhibitors of soluble epoxide hydrolase (sEH), such as 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA).	eets	105-109	epoxide hydrolase 2, cytoplasmic	Mus musculus	190-195
19333883-3	2009	Cardioprotective effects were also achieved when metabolism of the endogenous epoxyeicosatrienoic acids (EETs) by their major enzymatic hydrolysis pathway was blocked in gene knockout mice (EPHX2-/-) or by inhibitors of soluble epoxide hydrolase (sEH), such as 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA).	eets	105-109	epoxide hydrolase 2, cytoplasmic	Mus musculus	220-245
19333883-3	2009	Cardioprotective effects were also achieved when metabolism of the endogenous epoxyeicosatrienoic acids (EETs) by their major enzymatic hydrolysis pathway was blocked in gene knockout mice (EPHX2-/-) or by inhibitors of soluble epoxide hydrolase (sEH), such as 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA).	eets	105-109	epoxide hydrolase 2, cytoplasmic	Mus musculus	247-250
18973759-1	2009	Cytochrome P450 epoxygenases metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs) which are in turn converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	eets	92-96	epoxide hydrolase 2, cytoplasmic	Mus musculus	197-200
18725458-1	2008	Recent findings have indicated a role for cytochrome P-450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) in acute hypoxic pulmonary vasoconstriction (HPV).	eets	112-116	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	42-58
18836067-1	2009	Epoxy- and dihydroxy-eicosatrienoic acids (EETs and DHETs) are vasoactive cytochrome P450 metabolites of arachidonic acid.	eets	43-47	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	74-89
18725458-1	2008	Recent findings have indicated a role for cytochrome P-450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) in acute hypoxic pulmonary vasoconstriction (HPV).	eets	112-116	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	60-63
18716027-2	2008	Mouse CYP2J5 is abundant in the kidney where its products, the cis-epoxyeicosatrienoic acids (EETs), modulate sodium transport and vascular tone.	eets	94-98	cytochrome P450, family 2, subfamily j, polypeptide 5	Mus musculus	6-12
18776712-1	2008	Epoxyeicosatrienoic acids (EETs), including 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET, are produced by cytochrome P450 (P450) such as CYP2C8 and 2C9; and they are hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by epoxide hydrolase.	eets	27-31	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	135-141
19000441-1	2008	BACKGROUND & OBJECTIVE: Epoxyeicosatrienoic acids (EETs) are generated from arachidomic acid by cytochrome P450(CYP).	eets	55-59	peptidylprolyl isomerase G	Homo sapiens	116-119
18835921-1	2008	Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids.	eets	71-75	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
18835921-1	2008	Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids.	eets	71-75	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
18369166-3	2008	However, EETs are rapidly metabolized via soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	eets	9-13	epoxide hydrolase 2, cytoplasmic	Mus musculus	42-67
18369166-3	2008	However, EETs are rapidly metabolized via soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	eets	9-13	epoxide hydrolase 2, cytoplasmic	Mus musculus	69-72
17728042-1	2008	The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 arachidonic acid epoxygenases and metabolized through multiple pathways, including soluble epoxide hydrolase (sEH).	eets	48-52	epoxide hydrolase 2, cytoplasmic	Mus musculus	169-194
18340006-1	2008	OBJECTIVE: Cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) are known to stimulate angiogenesis, but the mechanisms involved are incompletely understood.	eets	80-84	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	11-26
18340006-1	2008	OBJECTIVE: Cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) are known to stimulate angiogenesis, but the mechanisms involved are incompletely understood.	eets	80-84	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	28-31
18181170-2	2008	Cytochrome P450 (CYP) epoxygenase-2J2 (CYP2J2) is abundant in the heart endothelium, and its AA metabolites epoxyeicosatrienoic acids (EETs) mitigates inflammation through NF-kappabeta.	eets	135-139	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	172-184
18378855-1	2008	The aim of the present cross-sectional study was to investigate whether activation of the renin-angiotensin system in renovascular disease affects the cytochrome P450 omega/omega-1 hydroxylase (20-hydroxyeicosatetraenoic acid [20-HETE]) and epoxygenase (epoxyeicosatrienoic acids [EETs]) pathways of arachidonic acid metabolism in vivo, each of which interacts with angiotensin II.	eets	281-285	renin	Homo sapiens	90-95
17728042-1	2008	The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 arachidonic acid epoxygenases and metabolized through multiple pathways, including soluble epoxide hydrolase (sEH).	eets	48-52	epoxide hydrolase 2, cytoplasmic	Mus musculus	196-199
17872452-2	2007	Here we address the mechanisms by which cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) contribute to this effect in native and cultured endothelial cells.	eets	97-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-55
17872452-2	2007	Here we address the mechanisms by which cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) contribute to this effect in native and cultured endothelial cells.	eets	97-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	57-60
17652182-1	2007	CYP2J2 is abundant in cardiac tissue and active in the biosynthesis of eicosanoids such as epoxyeicosatrienoic acids (EETs).	eets	118-122	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
17126841-1	2007	OBJECTIVES: Cytochrome P450 (CYP) 2J2 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which are potent endogenous vasodilators and inhibitors of vascular inflammation.	eets	158-162	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	12-37
17639071-1	2007	The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are endogenous lipid mediators produced in the brain by P450 epoxygenases and metabolized through multiple pathways, including soluble epoxide hydrolase (sEH).	eets	48-52	epoxide hydrolase 2	Rattus norvegicus	181-206
17634204-8	2007	Gas chromatography-mass spectrometry (GC-MS) analysis indicated a significant increase in arterial production of EETs in ERalpha-KO compared with WT mice.	eets	113-117	estrogen receptor 1 (alpha)	Mus musculus	121-128
17764757-1	2007	Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) are lipid signalling molecules that elicit vasodilatation and modulate various intracellular signalling cascades.	eets	57-61	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
17764757-1	2007	Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) are lipid signalling molecules that elicit vasodilatation and modulate various intracellular signalling cascades.	eets	57-61	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
17639071-1	2007	The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are endogenous lipid mediators produced in the brain by P450 epoxygenases and metabolized through multiple pathways, including soluble epoxide hydrolase (sEH).	eets	48-52	epoxide hydrolase 2	Rattus norvegicus	208-211
17460077-2	2007	EPHX2 encodes for soluble epoxide hydrolase (sEH), an important enzyme in the metabolic breakdown of arachidonic acid-derived eicosanoids referred to as epoxyeicosatrienoic acids (EETs).	eets	180-184	epoxide hydrolase 2	Homo sapiens	45-48
17341586-1	2007	TRPV4, a Ca(2+)-permeable member of the vanilloid subgroup of the transient receptor potential (TRP) channels, is activated by cell swelling and moderate heat (>27 degrees C) as well as by diverse chemical compounds including synthetic 4 alpha-phorbol esters, the plant extract bisandrographolide A, and endogenous epoxyeicosatrienoic acids (EETs; 5,6-EET and 8,9-EET).	eets	345-349	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
17460077-2	2007	EPHX2 encodes for soluble epoxide hydrolase (sEH), an important enzyme in the metabolic breakdown of arachidonic acid-derived eicosanoids referred to as epoxyeicosatrienoic acids (EETs).	eets	180-184	epoxide hydrolase 2	Homo sapiens	0-5
17460077-2	2007	EPHX2 encodes for soluble epoxide hydrolase (sEH), an important enzyme in the metabolic breakdown of arachidonic acid-derived eicosanoids referred to as epoxyeicosatrienoic acids (EETs).	eets	180-184	epoxide hydrolase 2	Homo sapiens	18-43
17130447-4	2006	We tested the use of soluble epoxide hydrolase (sEH) inhibitors as a means to enhance the biological activities of epoxyeicosatrienoic acids (EETs) to treat cardiac hypertrophy.	eets	142-146	epoxide hydrolase 2, cytoplasmic	Mus musculus	21-46
16987999-7	2007	EETs are metabolized primarily by conversion to dihydroxyeicosatrienoic acids (DHETs), a reaction catalyzed by soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2	Homo sapiens	111-136
16987999-7	2007	EETs are metabolized primarily by conversion to dihydroxyeicosatrienoic acids (DHETs), a reaction catalyzed by soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2	Homo sapiens	138-141
23045145-3	2007	Early work suggested a role of sEH in detoxifying a wide array of xenobiotic epoxides; however, recent findings clearly implicate the sEH in the regulation of blood pressure, pain, and inflammation through the hydrolysis of endogenous epoxy fatty acids such as epoxyeicosatrienoic acids (EETs).	eets	288-292	epoxide hydrolase 2	Homo sapiens	134-137
17164129-4	2007	A number of these enzymes, including members of the CYP 4 family, predominantly catalyze conversion of AA to 20-hydroxyeicosatetraenoic acid (20-HETE) while the CYP epoxygenases generate mainly epoxyeicosatrienoic acids (EETs).	eets	221-225	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	52-55
17164129-4	2007	A number of these enzymes, including members of the CYP 4 family, predominantly catalyze conversion of AA to 20-hydroxyeicosatetraenoic acid (20-HETE) while the CYP epoxygenases generate mainly epoxyeicosatrienoic acids (EETs).	eets	221-225	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	161-164
17164133-1	2007	Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases the expression of which is determined by hemodynamic and pharmacological stimuli as well as by hypoxia.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	72-87
17164133-1	2007	Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases the expression of which is determined by hemodynamic and pharmacological stimuli as well as by hypoxia.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-92
17130447-4	2006	We tested the use of soluble epoxide hydrolase (sEH) inhibitors as a means to enhance the biological activities of epoxyeicosatrienoic acids (EETs) to treat cardiac hypertrophy.	eets	142-146	epoxide hydrolase 2, cytoplasmic	Mus musculus	48-51
16380164-1	2006	Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	72-87
16868033-1	2006	CYP2J2 metabolizes arachidonic acid to 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids (EETs), which play a critical role in the regulation of renal, pulmonary, cardiac, and vascular function.	eets	102-106	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
16793897-1	2006	We have reported that epoxyeicosatrienoic acids (EETs), the cytochrome P450 (CYP) epoxygenase metabolites of arachidonic acid (AA), are potent sarcolemmal ATP-sensitive K+ (KATP) channel activators.	eets	49-53	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	60-75
16793897-1	2006	We have reported that epoxyeicosatrienoic acids (EETs), the cytochrome P450 (CYP) epoxygenase metabolites of arachidonic acid (AA), are potent sarcolemmal ATP-sensitive K+ (KATP) channel activators.	eets	49-53	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	77-80
16380164-1	2006	Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-92
18221075-2	2006	Soluble epoxide hydrolase (sEH, formerly referred to as cytosolic epoxide hydrolase), which is widely distributed in mammalian tissues, is the primary enzyme responsible for the conversion of epoxyeicosatrienoic acids (EETs), the bioactive lipid mediators formed from arachidonic acid by cytochrome P450 epoxygenase, to their corresponding diols.	eets	219-223	epoxide hydrolase 2	Homo sapiens	0-25
16857962-1	2006	Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (Ephx2, sEH).	eets	87-91	epoxide hydrolase 2, cytoplasmic	Mus musculus	184-189
16857962-1	2006	Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (Ephx2, sEH).	eets	87-91	epoxide hydrolase 2, cytoplasmic	Mus musculus	191-194
16490839-1	2006	Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by cytochrome P450 (CYP) epoxygenases.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-94
16490839-1	2006	Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by cytochrome P450 (CYP) epoxygenases.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	96-99
16714371-1	2006	Cytochrome P450 (P450) enzymes metabolize the membrane lipid arachidonic acid to stable biologically active epoxides [eicosatrienoic acids (EETs)] and 20-hydroxyeicosatetraenoic acid (20-HETE).	eets	140-144	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-21
16113065-3	2006	Here we examined the capacity of EETs and DHETs to activate peroxisome proliferator-activated receptor-alpha (PPARalpha).	eets	33-37	peroxisome proliferator activated receptor alpha	Homo sapiens	110-119
18221075-2	2006	Soluble epoxide hydrolase (sEH, formerly referred to as cytosolic epoxide hydrolase), which is widely distributed in mammalian tissues, is the primary enzyme responsible for the conversion of epoxyeicosatrienoic acids (EETs), the bioactive lipid mediators formed from arachidonic acid by cytochrome P450 epoxygenase, to their corresponding diols.	eets	219-223	epoxide hydrolase 2	Homo sapiens	27-30
16291720-1	2005	Recent studies suggest that cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) elicit cell proliferation and promote angiogenesis.	eets	97-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	28-43
16291720-1	2005	Recent studies suggest that cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) elicit cell proliferation and promote angiogenesis.	eets	97-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	45-48
16178456-1	2005	Interests on the effects of cytochrome P450 (CYP450) monooxygenases and epoxyeicosatrienoic acids (EETs) on myocardial ischemic-reperfusion injury has been increased in recent years.	eets	99-103	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	45-51
16267130-2	2005	In this study, we investigated whether epoxyeicosatrienoic acids (EETs), the catalytic products of cytochrome P450 epoxygenases, are PPARgamma ligands.	eets	66-70	peroxisome proliferator activated receptor gamma	Homo sapiens	133-142
16179585-3	2005	Activation by cell swelling and AA requires cytochrome P450 (CYP) epoxygenase activity to convert AA to epoxyeicosatrienoic acids (EETs) such as 5,6-EET, 8,9-EET, which both act as direct TRPV4 agonists.	eets	131-135	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	44-59
16179585-3	2005	Activation by cell swelling and AA requires cytochrome P450 (CYP) epoxygenase activity to convert AA to epoxyeicosatrienoic acids (EETs) such as 5,6-EET, 8,9-EET, which both act as direct TRPV4 agonists.	eets	131-135	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	61-64
16179585-3	2005	Activation by cell swelling and AA requires cytochrome P450 (CYP) epoxygenase activity to convert AA to epoxyeicosatrienoic acids (EETs) such as 5,6-EET, 8,9-EET, which both act as direct TRPV4 agonists.	eets	131-135	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	188-193
16315601-3	2005	We have demonstrated that cytochrome P450 (CYP) epoxygenase-dependent metabolites of arachidonic acid, epoxyeicosatrienoic acids (EETs), can robustly up-regulate eNOS expression and its activity, however the relevant signaling pathways responsible for activity regulation are not well known.	eets	130-134	nitric oxide synthase 3	Bos taurus	162-166
15814528-1	2005	Cytochrome P-450 (CYP)-dependent epoxyeicosatrienoic acids (EETs) dilate rat preglomerular microvessels when adenosine(2A) receptors (A(2A)R) are stimulated.	eets	60-64	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
15814528-1	2005	Cytochrome P-450 (CYP)-dependent epoxyeicosatrienoic acids (EETs) dilate rat preglomerular microvessels when adenosine(2A) receptors (A(2A)R) are stimulated.	eets	60-64	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	18-21
15729289-3	2005	Cytochrome P450 2C11 is an arachidonic acid (AA) epoxygenase expressed in astrocytes, which metabolizes AA to epoxyeicosatrienoic acids (EETs).	eets	137-141	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	11-15
15699457-1	2005	The soluble epoxide hydrolase (sEH) metabolizes vasodilatory epoxyeicosatrienoic acids (EETs) to their di-hydroxy derivatives.	eets	88-92	epoxide hydrolase 2, cytoplasmic	Mus musculus	4-29
15895105-1	2005	In coronary arteries, bradykinin opens endothelial intermediate- and small-conductance Ca2+-sensitive K+ channels (IK(Ca) and SK(Ca)) and, additionally, releases epoxyeicosatrienoic acids (EETs) from the endothelium.	eets	189-193	kininogen 1	Homo sapiens	22-32
15895105-8	2005	Bradykinin (but not substance P) also hyperpolarizes myocytes by a mechanism (independent of endothelial cell hyperpolarization) which involves endothelial cell production of EETs (most likely 14,15- and/or 11,12-EET).	eets	175-179	kininogen 1	Homo sapiens	0-10
15840038-2	2005	Recent studies suggest that an endothelial cytochrome P450 (CYP) epoxygenase (CYP 2C9) can modulate endothelium-dependent vasodilatation in two different ways: (1) by the production of epoxyeicosatrienoic acids (EETs), which elicit hyperpolarization and relaxation; and (2) by the release of oxygen-derived free radicals, which compromise the bioavailability of nitric oxide.	eets	212-216	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	78-85
15699457-1	2005	The soluble epoxide hydrolase (sEH) metabolizes vasodilatory epoxyeicosatrienoic acids (EETs) to their di-hydroxy derivatives.	eets	88-92	epoxide hydrolase 2, cytoplasmic	Mus musculus	31-34
15652503-1	2005	Arachidonic acid is oxidized by cytochromes P450 2C (CYP2C) to epoxyeicosatrienoic acids (EETs), possessing vasoactive properties, with 11,12-EET as the endothelium derived hyperpolarization factor.	eets	90-94	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	53-58
15680914-2	2005	We aimed to establish whether CYP2B19 is the source of epidermal epoxyeicosatrienoic acids (EETs), which are implicated in mechanisms regulating epidermal cornification.	eets	92-96	cytochrome P450, family 2, subfamily b, polypeptide 19	Mus musculus	30-37
15383399-1	2005	Epoxyeicosatrienoic acids (EETs), which belong to cytochrome P-450 (CYP)-derived eicosanoids, have been implicated to vasodilate renal arterioles, inhibit sodium transport in the nephron, and regulate blood pressure in several animal models.	eets	27-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	50-66
15383399-1	2005	Epoxyeicosatrienoic acids (EETs), which belong to cytochrome P-450 (CYP)-derived eicosanoids, have been implicated to vasodilate renal arterioles, inhibit sodium transport in the nephron, and regulate blood pressure in several animal models.	eets	27-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	68-71
15864120-1	2005	CYP2J2 and CYP2C8 metabolize arachidonic acid (AA) to cis-epoxyeicosatrienoic acids (EETs), which play a central role in regulating renal tubular fluid-electrolyte transport and vascular tone.	eets	85-89	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
15864120-1	2005	CYP2J2 and CYP2C8 metabolize arachidonic acid (AA) to cis-epoxyeicosatrienoic acids (EETs), which play a central role in regulating renal tubular fluid-electrolyte transport and vascular tone.	eets	85-89	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	11-17
15329052-3	2004	It has been proposed that ACh elicits a hyperpolarization of the coronary endothelial cells which may be accompanied by the activation of cytochrome P450 (CYP) and the resulting release of epoxyeicosatrienoic acids (EETs).	eets	216-220	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	155-158
15466638-1	2004	BACKGROUND: Cytochrome P450 (CYP) 2J2 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs).	eets	162-166	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	12-37
15145985-8	2004	Moreover, vicinal diol from both C18-epoxides and EETs were omega-hydroxylated by liver microsomes and by CYP4F2 and CYP4F3.	eets	50-54	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	106-112
15353362-4	2004	We have demonstrated that leukotrienes (LTs; 5-LOX-derived eicosanoids) and various isomers of epoxyeicosatrienoic acids (EETs; epoxygenase-derived eicosanoids) contribute to the process of endogenous antipyresis or cryogenesis, which limits the height of fever.	eets	122-126	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	128-139
15258110-7	2004	Human family 1 cytochromes P450 had unique regional specificities for arachidonate oxidation: the major metabolites of CYP1A1, CYP1A2, and CYP1B1 were 75% terminal hydroxyeicosatetraenoic fatty acids (HETEs), 52% epoxyeicosatrienoic fatty acids (EETs), and 54% mid-chain HETEs, respectively.	eets	246-250	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	119-125
15258110-7	2004	Human family 1 cytochromes P450 had unique regional specificities for arachidonate oxidation: the major metabolites of CYP1A1, CYP1A2, and CYP1B1 were 75% terminal hydroxyeicosatetraenoic fatty acids (HETEs), 52% epoxyeicosatrienoic fatty acids (EETs), and 54% mid-chain HETEs, respectively.	eets	246-250	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	127-133
15258110-7	2004	Human family 1 cytochromes P450 had unique regional specificities for arachidonate oxidation: the major metabolites of CYP1A1, CYP1A2, and CYP1B1 were 75% terminal hydroxyeicosatetraenoic fatty acids (HETEs), 52% epoxyeicosatrienoic fatty acids (EETs), and 54% mid-chain HETEs, respectively.	eets	246-250	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	139-145
15503650-4	2004	Cytochrome P450 metabolism of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) or epoxyeicosatrienoic acids (EETs) provides a mechanism for the constriction and relaxation of cerebral arteries, respectively.	eets	122-126	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
15145985-8	2004	Moreover, vicinal diol from both C18-epoxides and EETs were omega-hydroxylated by liver microsomes and by CYP4F2 and CYP4F3.	eets	50-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	117-123
15102943-6	2004	CYP2C50 and CYP2C54 metabolize AA to epoxyeicosatrienoic acids (EETs) primarily, and linoleic acid to epoxyoctadecenoic acids (EOAs) primarily, whereas CYP2C55 metabolizes AA to EETs and hydroxyeicosatetraenoic acids and linoleic acid to EOAs and hydroxyoctadecadienoic acids.	eets	64-68	cytochrome P450, family 2, subfamily c, polypeptide 50	Mus musculus	0-7
15102943-6	2004	CYP2C50 and CYP2C54 metabolize AA to epoxyeicosatrienoic acids (EETs) primarily, and linoleic acid to epoxyoctadecenoic acids (EOAs) primarily, whereas CYP2C55 metabolizes AA to EETs and hydroxyeicosatetraenoic acids and linoleic acid to EOAs and hydroxyoctadecadienoic acids.	eets	178-182	cytochrome P450, family 2, subfamily c, polypeptide 55	Mus musculus	152-159
15102943-6	2004	CYP2C50 and CYP2C54 metabolize AA to epoxyeicosatrienoic acids (EETs) primarily, and linoleic acid to epoxyoctadecenoic acids (EOAs) primarily, whereas CYP2C55 metabolizes AA to EETs and hydroxyeicosatetraenoic acids and linoleic acid to EOAs and hydroxyoctadecadienoic acids.	eets	64-68	cytochrome P450, family 2, subfamily c, polypeptide 54	Mus musculus	12-19
15102943-6	2004	CYP2C50 and CYP2C54 metabolize AA to epoxyeicosatrienoic acids (EETs) primarily, and linoleic acid to epoxyoctadecenoic acids (EOAs) primarily, whereas CYP2C55 metabolizes AA to EETs and hydroxyeicosatetraenoic acids and linoleic acid to EOAs and hydroxyoctadecadienoic acids.	eets	178-182	cytochrome P450, family 2, subfamily c, polypeptide 50	Mus musculus	0-7
12865253-1	2003	Nitric oxide (NO) inhibits hemoproteins, including cytochrome (CYP) 2C, the gene responsible for the production of epoxyeicosatrienoic acids (EETs).	eets	142-146	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	0-70
14718251-1	2004	Activation of rat adenosine2A receptors (A2A R) dilates preglomerular microvessels (PGMV), an effect mediated by epoxyeicosatrienoic acids (EETs).	eets	140-144	adenosine A2a receptor	Rattus norvegicus	18-39
14718251-1	2004	Activation of rat adenosine2A receptors (A2A R) dilates preglomerular microvessels (PGMV), an effect mediated by epoxyeicosatrienoic acids (EETs).	eets	140-144	adenosine A2a receptor	Rattus norvegicus	41-46
14626496-2	2003	CYP-AA metabolites, 19- and 20-hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs) and diHETEs have different biological properties based on sites of production and can be stored in tissue lipids and released in response to hormonal stimuli.	eets	97-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
12975498-1	2003	Cytochrome P450 (P450)-dependent metabolites of arachidonic acid, the epoxyeicosatrienoic acids (EETs), are proposed to be endothelium-derived hyperpolarizing factors (EDHF) that affect vascular tone; however, the effects of EDHF on endothelial-derived nitric oxide biosynthesis remain unknown.	eets	97-101	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-21
12939236-2	2003	Renal cytochrome P450 (CYP)-derived eicosanoids--hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DHETs)--have been shown to play an important role in the regulation of renal function, vascular tone, and blood pressure.	eets	115-119	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	6-21
12939236-2	2003	Renal cytochrome P450 (CYP)-derived eicosanoids--hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DHETs)--have been shown to play an important role in the regulation of renal function, vascular tone, and blood pressure.	eets	115-119	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	23-26
12892558-3	2003	In particular, there has been considerable support for a role for the cytochrome P450 metabolites, the epoxyeicosatrienoic acids (EETs).	eets	130-134	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-85
11773611-1	2002	Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and that these compounds play critical roles in the regulation of renal, pulmonary, and cardiac function and vascular tone.	eets	242-246	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	80-96
12623785-2	2003	We hypothesized that increased production of arachidonic acid metabolites such as the cyclooxygenase product prostacyclin or cytochrome p-450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) contributes to VSM cell hyperpolarization following CH.	eets	195-199	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	125-141
12623785-2	2003	We hypothesized that increased production of arachidonic acid metabolites such as the cyclooxygenase product prostacyclin or cytochrome p-450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) contributes to VSM cell hyperpolarization following CH.	eets	195-199	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	143-146
12675279-6	2003	Purified CYP3A4 produced epoxyeicosatrienoic acids (EETs) from arachidonic acid, and the production was abolished by a selective CYP3A inhibitor, ketoconazole.	eets	52-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	9-15
12016269-2	2002	The epoxyeicosatrienoic acids (EETs), which are products of cytochrome P450 (CYP) epoxygenases, possess vasodilatory, antiinflammatory, and fibrinolytic properties.	eets	31-35	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	60-75
12016269-2	2002	The epoxyeicosatrienoic acids (EETs), which are products of cytochrome P450 (CYP) epoxygenases, possess vasodilatory, antiinflammatory, and fibrinolytic properties.	eets	31-35	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	77-80
11964373-2	2002	Here, we assessed the mechanisms by which the epoxyeicosatrienoic acids (EETs) generated by a CYP 2C enzyme control interendothelial gap junctional communication.	eets	73-77	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	94-100
11773611-1	2002	Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and that these compounds play critical roles in the regulation of renal, pulmonary, and cardiac function and vascular tone.	eets	242-246	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	98-101
10924087-1	2000	Epoxyeicosatrienoic acids (EETs) are cytochrome P-450 metabolites of arachidonic acid involved in the regulation of vascular tone.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	37-53
11789779-2	2001	The cytochrome P-450-monooxygenase metabolites of arachidonic acid (epoxyeicosatrienoic acids [EETs]) have been suggested to be EDHF.	eets	95-99	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	4-34
11195057-1	2001	Recent studies indicate that arachidonic acid is primarily metabolized by cytochrome P450 enzymes of the 4A and 2C families in the kidney to 20-hydroxyeicosatetraenoic acid (HETE), epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids.	eets	208-212	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	74-89
11455018-1	2001	CYP2J2 is abundant in human heart and its arachidonic acid metabolites, the epoxyeicosatrienoic acids (EETs), have potent vasodilatory, antiinflammatory and cardioprotective properties.	eets	103-107	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
11125019-1	2001	Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites of cytochrome P450 monooxygenase, which are released from endothelial cells and dilate arteries.	eets	27-31	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	69-98
9430380-1	1997	Arachidonic acid is converted to epoxyeicosatrienoic acids (EETs) by cytochrome P450 monooxygenases.	eets	60-64	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	69-84
10813596-6	2000	So, we propose that the higher CYP2C content in SIDS stimulates the production of EETs and diHETEs and might have severe pathologic consequences in children.	eets	82-86	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	31-36
9786938-7	1998	EETs also stimulated association of PI3-kinase with EGFR.	eets	0-4	epidermal growth factor receptor	Homo sapiens	52-56
10779386-1	2000	Epoxyeicosatrienoic acids (EETs) are major products of cytochrome P450 (CYP)-catalyzed metabolism of arachidonic acid in the kidney.	eets	27-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	55-70
10779386-1	2000	Epoxyeicosatrienoic acids (EETs) are major products of cytochrome P450 (CYP)-catalyzed metabolism of arachidonic acid in the kidney.	eets	27-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	72-75
9927620-1	1999	Epoxyeicosatrienoic acids (EETs), products of the cytochrome P-450 monooxygenase metabolism of arachidonic acid, can regulate the activity of ion channels.	eets	27-31	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	50-80
8897950-1	1996	Arachidonic acid (AA) is metabolized by the cytochrome P-450 (P-450) epoxygenase pathway to epoxyeicosatrienoic acids (EETs) in the brain parenchymal tissue and perivascular astrocytes.	eets	119-123	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	44-60
9242187-1	1997	Epoxyeicosatrienoic acids (EETs) are potent endothelium-derived vasodilators formed from cytochrome P-450 metabolism of arachidonic acid.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-105
9242187-9	1997	We conclude that incorporation of EETs and DHETs into cell lipids results in potentiation of bradykinin-induced relaxation in porcine coronary arteries, providing the first evidence that incorporated EETs and DHETs are capable of modulating vascular function.	eets	34-38	kininogen 1	Homo sapiens	93-103
9242187-9	1997	We conclude that incorporation of EETs and DHETs into cell lipids results in potentiation of bradykinin-induced relaxation in porcine coronary arteries, providing the first evidence that incorporated EETs and DHETs are capable of modulating vascular function.	eets	200-204	kininogen 1	Homo sapiens	93-103
7738183-2	1995	Microsomal fractions prepared from rabbit lung homogenates metabolized arachidonic acid through cytochrome P450 pathways, yielding cis-epoxyeicosatrienoic acids (EETs) and their hydration products, vic-dihydroxyeicosatrienoic acids, mid-chain cis-trans conjugated dienols, and 19- and 20-hydroxyeicosatetraenoic acids.	eets	162-166	cytochrome P-450	Oryctolagus cuniculus	96-111
7625847-3	1995	Liver CYP arachidonate products include epoxyeicosatrienoic acids (EETs) and monohydroxylated products (HETEs).	eets	67-71	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	6-9
1968382-1	1990	The epoxyeicosatrienoic acids (EETs) were discovered as products of a cyclooxygenase/lipoxygenase-independent, cytochrome P-450 catalyzed metabolism of arachidonic acid (AA) termed the "epoxygenase" pathway.	eets	31-35	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	111-127
8246128-6	1993	Arachidonic acid metabolism catalyzed by expressed CYP2C23 indicated that CYP2C23 efficiently produced epoxyeicosatrienoic acids (EETs).	eets	130-134	cytochrome P450, family 2, subfamily c, polypeptide 23	Rattus norvegicus	51-58
8246128-6	1993	Arachidonic acid metabolism catalyzed by expressed CYP2C23 indicated that CYP2C23 efficiently produced epoxyeicosatrienoic acids (EETs).	eets	130-134	cytochrome P450, family 2, subfamily c, polypeptide 23	Rattus norvegicus	74-81
2124686-1	1990	In the presence of NADPH cytochrome P-450-dependent monooxygenases oxidize arachidonic acid giving rise to four epoxyeicosatrienoic acids (EETs) which are hydrolyzed enzymatically to dihydroxyeicosatrienoic acids (DHETs).	eets	139-143	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	25-41
7721444-1	1995	Phospholipase A2 (Naja mocambique) catalyzed release of epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) from phospholipids of isolated human platelets.	eets	83-87	phospholipase A2 group IB	Homo sapiens	0-16
7840649-1	1995	The metabolism of cis-epoxyeicosatrienoic acids (EETs), methyl cis-epoxyeicosatrienoates, and cis-epoxyeicosanoic acids by cytosolic epoxide hydrolase was studied to identify substrate structural features important for stereoselective metabolism and chiral diol formation.	eets	49-53	epoxide hydrolase 2	Rattus norvegicus	123-150
7952074-1	1994	A chromatographic method was developed to separate enantiomers of four regioisomeric epoxyeicosatrienoic acids (EETs), which are cytochrome P-450 monooxygenase products of arachidonic acid.	eets	112-116	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	129-159
8388882-1	1993	Epoxyeicosatrienoic acids (EETs), cytochrome P-450 metabolites of arachidonic acid, have attracted attention because of their effects on stimulus-response coupling in endocrine, renal, and vascular cells.	eets	27-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	34-50
33588415-2	2020	sEH metabolizes biologically highly active and generally cytoprotective epoxyeicosatrienoic acids (EETs), generated from arachidonic acid metabolism by CYP epoxygenases (CYP2C and CYP2J subfamilies), to less active corresponding diols.	eets	99-103	epoxide hydrolase 2	Homo sapiens	0-3
33777999-2	2020	The aim of this study was to assess the cardiovascular impact of the pharmacological inhibition of soluble epoxide hydrolase (sEH), which metabolizes the endothelium-derived vasodilatory and anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acid (DHETs), in the 5/6 nephrectomy (Nx) mouse model.	eets	236-240	epoxide hydrolase 2, cytoplasmic	Mus musculus	99-124
33777999-2	2020	The aim of this study was to assess the cardiovascular impact of the pharmacological inhibition of soluble epoxide hydrolase (sEH), which metabolizes the endothelium-derived vasodilatory and anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acid (DHETs), in the 5/6 nephrectomy (Nx) mouse model.	eets	236-240	epoxide hydrolase 2, cytoplasmic	Mus musculus	126-129
34794001-2	2021	The soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatetraenoic acids.	eets	74-78	epoxide hydrolase 2	Rattus norvegicus	31-34
34922004-3	2022	The enzyme soluble epoxide hydrolase (sEH) hydrolyzes EETs to less active diols, and we hypothesized that pharmacologic sEH inhibition would decrease adipose inflammation in obese individuals.	eets	54-58	epoxide hydrolase 2	Homo sapiens	11-36
34922004-3	2022	The enzyme soluble epoxide hydrolase (sEH) hydrolyzes EETs to less active diols, and we hypothesized that pharmacologic sEH inhibition would decrease adipose inflammation in obese individuals.	eets	54-58	epoxide hydrolase 2	Homo sapiens	38-41
34922004-3	2022	The enzyme soluble epoxide hydrolase (sEH) hydrolyzes EETs to less active diols, and we hypothesized that pharmacologic sEH inhibition would decrease adipose inflammation in obese individuals.	eets	54-58	epoxide hydrolase 2	Homo sapiens	120-123
34817988-8	2021	This study demonstrates that alkoxy- groups are potent and more metabolically stable bioisostere alternatives to the epoxide within EETs that enable sEH-independent activity.	eets	132-136	epoxide hydrolase 2	Homo sapiens	149-152
34774051-1	2021	BACKGROUND: Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert anti-inflammatory, anti-apoptotic, pro-proliferative, and antioxidant effects on the cardiovascular system.	eets	112-116	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	12-43
34597782-5	2021	Moreover, ZM241385 (A2AR inhibitor) attenuated the cardioprotective properties of EETs.	eets	82-86	adenosine A2a receptor	Mus musculus	20-24
34591792-2	2021	Hydrolysis of EETs by soluble epoxide hydrolase (sEH/EPHX2) to less active diols attenuates their anti-inflammatory effects.	eets	14-18	epoxide hydrolase 2, cytoplasmic	Mus musculus	49-52
34591792-2	2021	Hydrolysis of EETs by soluble epoxide hydrolase (sEH/EPHX2) to less active diols attenuates their anti-inflammatory effects.	eets	14-18	epoxide hydrolase 2, cytoplasmic	Mus musculus	53-58
34774051-1	2021	BACKGROUND: Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert anti-inflammatory, anti-apoptotic, pro-proliferative, and antioxidant effects on the cardiovascular system.	eets	112-116	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	45-51
34774051-4	2021	METHODS: CYP2J2 gene was transfected into rat lung tissue by recombinant adeno-associated virus (rAAV) to increase the levels of EETs in serum and lung tissue.	eets	129-133	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	9-15
34774051-7	2021	In addition, exogenous EETs suppressed inflammatory response and reduced intracellular reactive oxygen species (ROS) production and inhibited apoptosis in a tumor necrosis factor alpha (TNF-alpha) combined hypoxia-reoxygenation model of HPAECs.	eets	23-27	tumor necrosis factor	Rattus norvegicus	157-184
34774051-7	2021	In addition, exogenous EETs suppressed inflammatory response and reduced intracellular reactive oxygen species (ROS) production and inhibited apoptosis in a tumor necrosis factor alpha (TNF-alpha) combined hypoxia-reoxygenation model of HPAECs.	eets	23-27	tumor necrosis factor	Homo sapiens	186-195
34548575-9	2021	Our results provide the first experimental evidence that Cyp2c44-derived EETs in the VSMC mediate vasoconstriction of the ophthalmic artery.	eets	73-77	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	57-64
34592333-2	2021	Soluble epoxide hydrolase (sEH) is the key enzyme in the epoxyeicosatrienoic acids (EETs) signaling.	eets	84-88	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
34592333-2	2021	Soluble epoxide hydrolase (sEH) is the key enzyme in the epoxyeicosatrienoic acids (EETs) signaling.	eets	84-88	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
34672113-2	2022	Epoxyeicosatrienoic acids (EETs) are endogenous anti-inflammatory mediators, rapidly metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	eets	27-31	epoxide hydrolase 2	Homo sapiens	100-125
34672113-2	2022	Epoxyeicosatrienoic acids (EETs) are endogenous anti-inflammatory mediators, rapidly metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs).	eets	27-31	epoxide hydrolase 2	Homo sapiens	127-130
34672113-3	2022	We hypothesized that sEH driven metabolism of the EETs to DHETs plays a critical role in chronic joint pain associated with OA and provides a new target for treatment.	eets	50-54	epoxide hydrolase 2	Homo sapiens	21-24
34672113-4	2022	METHODS: Potential associations between chronic knee pain in people and single nucleotide polymorphisms (SNPs) in the gene encoding sEH and circulating levels of the EETs and DHETs were investigated.	eets	166-170	epoxide hydrolase 2	Homo sapiens	132-135
34639055-4	2021	EETs are rapidly metabolized primarily via the soluble epoxide hydrolase (sEH) pathway.	eets	0-4	epoxide hydrolase 2	Homo sapiens	47-72
34639055-4	2021	EETs are rapidly metabolized primarily via the soluble epoxide hydrolase (sEH) pathway.	eets	0-4	epoxide hydrolase 2	Homo sapiens	74-77
34509915-1	2021	Soluble epoxide hydrolase (sEH), an enzyme that broadly regulates the cardiovascular system, hydrolyses epoxyeicosatrienoic acids (EETs) to their corresponding dihydroxyeicosatrienoic acids (DHETs).	eets	131-135	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
34509915-1	2021	Soluble epoxide hydrolase (sEH), an enzyme that broadly regulates the cardiovascular system, hydrolyses epoxyeicosatrienoic acids (EETs) to their corresponding dihydroxyeicosatrienoic acids (DHETs).	eets	131-135	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
34411643-0	2021	Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer"s disease through GSK3beta signaling pathway.	eets	47-51	epoxide hydrolase 2, cytoplasmic	Mus musculus	14-17
34411643-0	2021	Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer"s disease through GSK3beta signaling pathway.	eets	47-51	glycogen synthase kinase 3 alpha	Mus musculus	91-99
34411643-7	2021	Furthermore, inhibition of sEH could ameliorate neuroinflammation, neuronal death, and oxidative stress via stabilizing the in vivo level of epoxyeicosatrienoic acids (EETs), especially 8,9-EET and 14,15-EET, further resulting in the anti-AD effect through the regulation of GSK3beta-mediated NF-kappaB, p53, and Nrf2 signaling pathways.	eets	168-172	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
34411643-7	2021	Furthermore, inhibition of sEH could ameliorate neuroinflammation, neuronal death, and oxidative stress via stabilizing the in vivo level of epoxyeicosatrienoic acids (EETs), especially 8,9-EET and 14,15-EET, further resulting in the anti-AD effect through the regulation of GSK3beta-mediated NF-kappaB, p53, and Nrf2 signaling pathways.	eets	168-172	glycogen synthase kinase 3 alpha	Mus musculus	275-283
34411643-7	2021	Furthermore, inhibition of sEH could ameliorate neuroinflammation, neuronal death, and oxidative stress via stabilizing the in vivo level of epoxyeicosatrienoic acids (EETs), especially 8,9-EET and 14,15-EET, further resulting in the anti-AD effect through the regulation of GSK3beta-mediated NF-kappaB, p53, and Nrf2 signaling pathways.	eets	168-172	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	293-302
34411643-7	2021	Furthermore, inhibition of sEH could ameliorate neuroinflammation, neuronal death, and oxidative stress via stabilizing the in vivo level of epoxyeicosatrienoic acids (EETs), especially 8,9-EET and 14,15-EET, further resulting in the anti-AD effect through the regulation of GSK3beta-mediated NF-kappaB, p53, and Nrf2 signaling pathways.	eets	168-172	transformation related protein 53, pseudogene	Mus musculus	304-307
34411643-7	2021	Furthermore, inhibition of sEH could ameliorate neuroinflammation, neuronal death, and oxidative stress via stabilizing the in vivo level of epoxyeicosatrienoic acids (EETs), especially 8,9-EET and 14,15-EET, further resulting in the anti-AD effect through the regulation of GSK3beta-mediated NF-kappaB, p53, and Nrf2 signaling pathways.	eets	168-172	nuclear factor, erythroid derived 2, like 2	Mus musculus	313-317
34646152-1	2021	Background: Soluble epoxide hydrolase inhibitors (sEHis) inhibit the degradation of epoxyeicosatrienoic acids (EETs) in cells, and EETs have antiarrhythmic effects.	eets	111-115	epoxide hydrolase 2, cytoplasmic	Mus musculus	12-37
34063817-1	2021	Soluble epoxide hydrolase (sEH) is abundant in the brain, is upregulated in type 2 diabetes mellitus (DM2), and is possible mediator of ischemic injury via the breakdown of neuroprotective epoxyeicosatrienoic acids (EETs).	eets	216-220	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
34455816-1	2021	Epoxyeicosatrienoic acids (EETs) reduce blood pressure by acting in the vasculature and kidney, and interventions to increase circulating EETs improve insulin sensitivity and prevent diabetes in animal models.	eets	138-142	insulin	Homo sapiens	151-158
34455816-3	2021	We tested the hypothesis that sEH inhibition increases circulating EETs, reduces blood pressure, and improves insulin sensitivity, blood flow, and inflammation in a randomized, double-blind, placebo-controlled crossover study.	eets	67-71	epoxide hydrolase 2	Homo sapiens	30-33
34405221-2	2021	Three major enzymatic pathways including the cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 monooxygenase (CYP450) pathways are involved in AA metabolism leading to the generation of a variety of lipid mediators such as prostaglandins, leukotrienes, hydroxyeicosatetraenoic acids (HETEs) and epoxyeicoastrienoic acids (EETs).	eets	333-337	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	90-119
34142887-2	2021	Epoxyeicosatrienoic acids (EETs), hydrolyzed by soluble epoxide hydrolase (sEH), have beneficial effects against vascular dysfunction.	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	48-73
34142887-2	2021	Epoxyeicosatrienoic acids (EETs), hydrolyzed by soluble epoxide hydrolase (sEH), have beneficial effects against vascular dysfunction.	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	75-78
34063817-1	2021	Soluble epoxide hydrolase (sEH) is abundant in the brain, is upregulated in type 2 diabetes mellitus (DM2), and is possible mediator of ischemic injury via the breakdown of neuroprotective epoxyeicosatrienoic acids (EETs).	eets	216-220	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
35303234-2	2022	However, because of their rapid metabolism by the soluble epoxide hydrolase (sEH), EETs are unable to remain bioavailable.	eets	83-87	epoxide hydrolase 2	Rattus norvegicus	50-75
34707002-4	2021	Cytochrome P450 2J2 (CYP2J2) is the main enzyme which mediates arachidonic acid to produce epoxyeicosatrienoic acids (EETs) in human tissues.	eets	118-122	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-19
34707002-4	2021	Cytochrome P450 2J2 (CYP2J2) is the main enzyme which mediates arachidonic acid to produce epoxyeicosatrienoic acids (EETs) in human tissues.	eets	118-122	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	21-27
34707002-5	2021	It has been reported that EETs involve in the development of cancer, while the roles of EETs in PDAC and ferroptosis remain unclear.This study aims to explore the effect of CYP2J2/EETs on ferroptosis of human pancreatic ductal adenocarcinoma cells PANC-1 cells and the underlying mechanisms.	eets	88-92	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	173-179
34707002-23	2021	EETs inhibit the ferroptosis via up-regulation of GPX4 in a PPARgamma-dependent manner, which contributes to the ferroptosis resistance of PDAC.	eets	0-4	glutathione peroxidase 4	Homo sapiens	50-54
34707002-23	2021	EETs inhibit the ferroptosis via up-regulation of GPX4 in a PPARgamma-dependent manner, which contributes to the ferroptosis resistance of PDAC.	eets	0-4	peroxisome proliferator activated receptor gamma	Homo sapiens	60-69
35303234-2	2022	However, because of their rapid metabolism by the soluble epoxide hydrolase (sEH), EETs are unable to remain bioavailable.	eets	83-87	epoxide hydrolase 2	Rattus norvegicus	77-80
33994786-1	2020	Purpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury owing to their participation in the regulation of vascular tone and cerebral blood flow.	eets	139-143	epoxide hydrolase 2	Homo sapiens	9-34
35597366-8	2022	However, in contrast to CYP450-epoxygenases, sEH converts EETs into dihydroxyeicosatrienoic acid (DHETs), EpOMEs into dihydroxyoctadecaenoic acid (DiHOMEs), and others and reverses the beneficial effects of epoxy-fatty acids leading to vasoconstriction, reducing CRH, increase in pro-inflammation, increase in pro-thrombotic and become less cardioprotective.	eets	58-62	epoxide hydrolase 2, cytoplasmic	Mus musculus	45-48
35474783-2	2022	On the other hand, CYP2C8 is not only crucial for alteration in the pharmacokinetics of drugs to cause drug interaction but also unequivocally important for the metabolism of endogenous substances like the formation of epoxyeicosatrienoic acids (EETs), which are considered as signaling molecules against hallmarks of cancer.	eets	246-250	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	19-25
35229747-2	2022	The biological activity of EETs is terminated when being metabolized by soluble epoxide hydrolase (sEH), a process that serves as a key regulator of tissue EETs levels.	eets	156-160	epoxide hydrolase 2	Homo sapiens	99-102
35229747-3	2022	EETs act through several signaling pathways to mediate various beneficial effects, including anti-inflammation, anti-apoptosis, and anti-oxidation with relieve of endoplasmic reticulum stress, thereby sEH has become a potential therapeutic target in cardiovascular disease and cancer therapy.	eets	0-4	epoxide hydrolase 2	Homo sapiens	201-204
35229747-6	2022	Genetic ablation as well as pharmacologic inhibition of sEH has greatly helped to elucidate the physiologic actions of EETs, and maintaining or elevating brain EETs level has been demonstrated beneficial effects in CNS disease models.	eets	119-123	epoxide hydrolase 2	Homo sapiens	56-59
35229747-6	2022	Genetic ablation as well as pharmacologic inhibition of sEH has greatly helped to elucidate the physiologic actions of EETs, and maintaining or elevating brain EETs level has been demonstrated beneficial effects in CNS disease models.	eets	160-164	epoxide hydrolase 2	Homo sapiens	56-59
35229747-7	2022	Here, we review the literature regarding the studies on the bioactivity of EETs and their metabolic enzyme sEH with special attention paid to their action mechanisms in the CNS, including their modulation of neuronal activity, attenuation of neuroinflammation, regulation of cerebral blood flow, and improvement of neuronal and glial cells survival.	eets	75-79	epoxide hydrolase 2	Homo sapiens	107-110
33624376-6	2021	Microglial TRPV4 signaling required intermediary activation of phospholipase A2 (PLA2), cytochrome P450, and epoxyeicosatrienoic acid production (EETs).	eets	146-150	transient receptor potential cation channel subfamily V member 4	Homo sapiens	11-16
33990688-1	2021	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that are rapidly metabolized into diols by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2	Homo sapiens	112-137
33990688-1	2021	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that are rapidly metabolized into diols by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2	Homo sapiens	139-142
35344709-3	2022	Epoxyeicosatrienoic acids (EETs) were reported to have anti-hypertensive effects, which could be degraded by soluble epoxide hydrolase (sEH), encoded by EPHX2.	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	109-134
35344709-3	2022	Epoxyeicosatrienoic acids (EETs) were reported to have anti-hypertensive effects, which could be degraded by soluble epoxide hydrolase (sEH), encoded by EPHX2.	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	136-139
35344709-3	2022	Epoxyeicosatrienoic acids (EETs) were reported to have anti-hypertensive effects, which could be degraded by soluble epoxide hydrolase (sEH), encoded by EPHX2.	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	153-158
35183688-2	2022	Soluble epoxide hydrolase (sEH), encoded by the EPHX2 gene, degrades EETs into less biologically active metabolites.	eets	69-73	epoxide hydrolase 2	Homo sapiens	0-25
35183688-2	2022	Soluble epoxide hydrolase (sEH), encoded by the EPHX2 gene, degrades EETs into less biologically active metabolites.	eets	69-73	epoxide hydrolase 2	Homo sapiens	27-30
35183688-2	2022	Soluble epoxide hydrolase (sEH), encoded by the EPHX2 gene, degrades EETs into less biologically active metabolites.	eets	69-73	epoxide hydrolase 2	Homo sapiens	48-53
2556446-1	1989	AA is metabolized by a cytochrome P450, NADPH-dependent epoxygenase to four regioisomeric epoxyeicosatrienoic acids (EETs).	eets	117-121	cytochrome P-450	Oryctolagus cuniculus	23-38
4051502-1	1985	The catalysis of glutathione (GSH) conjugation to epoxyeicosatrienoic acids (EETs) by various purified isozymes of glutathione S-transferase was studied.	eets	77-81	glutathione S-transferase kappa 1	Homo sapiens	115-140
3924104-5	1985	NADPH-dependent synthesis of both EETs and DHETs from arachidonate by hepatic microsomal cytochrome P-450-mono-oxygenase activity was demonstrable with these methods and was significantly suppressed by the compound BW755C (500 microM), but not by eicosa-5,8,11,14-tetraynoic acid (ETYA, 20 microM) or by nordihydroguaiaretic acid (NDGA, 50 microM).	eets	34-38	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	89-120
34044117-1	2021	Extrahepatic CYP2J2 metabolism of arachidonic acid (AA) to bioactive regioisomeric epoxyeicosatrienoic acids (EETs) is implicated in both physiological and pathological conditions.	eets	110-114	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	13-19
34038767-5	2021	We postulated that hyperglycemia-induced elevation in sEH leads to a reduction in its substrates, epoxyeicosatrienoic acids (EETs), and attenuates the function of beta-cells.	eets	125-129	epoxide hydrolase 2	Homo sapiens	54-57
33994786-1	2020	Purpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury owing to their participation in the regulation of vascular tone and cerebral blood flow.	eets	139-143	epoxide hydrolase 2	Homo sapiens	36-39
33994786-1	2020	Purpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury owing to their participation in the regulation of vascular tone and cerebral blood flow.	eets	139-143	epoxide hydrolase 1	Homo sapiens	45-73
33994786-1	2020	Purpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury owing to their participation in the regulation of vascular tone and cerebral blood flow.	eets	139-143	epoxide hydrolase 1, microsomal	Mus musculus	75-78
33378686-2	2021	Soluble epoxide hydrolase (sEH) is the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), which have biological activity of regulating lipid metabolism.	eets	96-100	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
33378686-2	2021	Soluble epoxide hydrolase (sEH) is the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), which have biological activity of regulating lipid metabolism.	eets	96-100	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
33938800-4	2021	This study assesses whether the septal flap affects sinonasal QOL outcomes for patients receiving EETS for pituitary adenoma.	eets	98-102	arachidonate 5-lipoxygenase activating protein	Homo sapiens	39-43
33864813-2	2021	EETs could be readily converted to less biological active diols by soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2, cytoplasmic	Mus musculus	67-92
33864813-2	2021	EETs could be readily converted to less biological active diols by soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2, cytoplasmic	Mus musculus	94-97
33595911-4	2021	Soluble epoxide hydrolase (sEH) is an enzyme that degrades epoxyeicosatrienoic acids (EETs), which have multiple protective effects by suppressing inflammation, apoptosis and oxidative stress.	eets	86-90	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
33595911-4	2021	Soluble epoxide hydrolase (sEH) is an enzyme that degrades epoxyeicosatrienoic acids (EETs), which have multiple protective effects by suppressing inflammation, apoptosis and oxidative stress.	eets	86-90	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
33674953-6	2021	We found that mice with disrupted astrocytic IGF1R signaling exhibit impaired NVC responses, decreased stimulated release of the vasodilator gliotransmitter epoxy-eicosatrienoic acids (EETs), and upregulation of soluble epoxy hydrolase (sEH), which metabolizes and inactivates EETs.	eets	185-189	insulin-like growth factor I receptor	Mus musculus	45-50
33583202-2	2021	EETs cause vasodilation, exert anti-inflammatory effects, and enhance insulin secretion and sensitivity in rodents.	eets	0-4	insulin	Homo sapiens	70-77
33279296-2	2021	In addition to the two metabolic pathways regulated by cyclooxygenase and lipoxygenase, AA has a third metabolic pathway through which cytochrome P450 (CYP) enzymes produce hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs).	eets	242-246	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	135-150
33964840-7	2021	In cultered endothelial cells also was demonstrated anti-inflammatory action of EETs when they significantly decreased TNF-alpha-induced high level of monocyte chemoattractant protein-1, which was reversed by EETs antagonist.	eets	80-84	tumor necrosis factor	Rattus norvegicus	119-128
33964840-7	2021	In cultered endothelial cells also was demonstrated anti-inflammatory action of EETs when they significantly decreased TNF-alpha-induced high level of monocyte chemoattractant protein-1, which was reversed by EETs antagonist.	eets	80-84	C-C motif chemokine ligand 2	Rattus norvegicus	151-185
33964840-7	2021	In cultered endothelial cells also was demonstrated anti-inflammatory action of EETs when they significantly decreased TNF-alpha-induced high level of monocyte chemoattractant protein-1, which was reversed by EETs antagonist.	eets	209-213	tumor necrosis factor	Rattus norvegicus	119-128
33964840-7	2021	In cultered endothelial cells also was demonstrated anti-inflammatory action of EETs when they significantly decreased TNF-alpha-induced high level of monocyte chemoattractant protein-1, which was reversed by EETs antagonist.	eets	209-213	C-C motif chemokine ligand 2	Rattus norvegicus	151-185
33580125-1	2021	This study addressed the hypothesis that epoxyeicosatrienoic acids (EETs) synthesized by CYP450 and catabolized by soluble epoxide hydrolase (sEH) are involved in the maintenance of renal allograft function, either directly or through modulation of cardiovascular function.	eets	68-72	epoxide hydrolase 2, cytoplasmic	Mus musculus	115-140
33580125-1	2021	This study addressed the hypothesis that epoxyeicosatrienoic acids (EETs) synthesized by CYP450 and catabolized by soluble epoxide hydrolase (sEH) are involved in the maintenance of renal allograft function, either directly or through modulation of cardiovascular function.	eets	68-72	epoxide hydrolase 2, cytoplasmic	Mus musculus	142-145
32943781-9	2021	The increase in wall shear stress in the peripheral conduit arteries induces a release of t-PA by a mechanism involving NO and EETs.	eets	127-131	plasminogen activator, tissue type	Homo sapiens	90-94
33279296-2	2021	In addition to the two metabolic pathways regulated by cyclooxygenase and lipoxygenase, AA has a third metabolic pathway through which cytochrome P450 (CYP) enzymes produce hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs).	eets	242-246	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	152-155
33337352-1	2021	This study aimed to investigate the effects of arachidonic acid metabolite epoxyeicosatrienoic acid (EETs) in the apoptosis of endothelial cells induced by tumor necrosis factor-alpha (TNF-alpha).	eets	101-105	tumor necrosis factor	Homo sapiens	156-183
33369424-2	2021	The inhibition of sEH can effectively maintain endogenous epoxyeicosatrienoic acids (EETs) levels and reduce dihydroxyeicosatrienoic acids (DHETs) levels, resulting in therapeutic potentials for cardiovascular, central nervous system, and metabolic diseases.	eets	85-89	epoxide hydrolase 2	Homo sapiens	18-21
33788190-6	2021	More detail is provided to introduce a less recognized gene of Ephx2 that encodes soluble epoxide hydrolase (sEH) to degrade epoxyeicosatrienic acids (EETs).	eets	151-155	epoxide hydrolase 2	Homo sapiens	63-68
33788190-6	2021	More detail is provided to introduce a less recognized gene of Ephx2 that encodes soluble epoxide hydrolase (sEH) to degrade epoxyeicosatrienic acids (EETs).	eets	151-155	epoxide hydrolase 2	Homo sapiens	82-107
33788190-6	2021	More detail is provided to introduce a less recognized gene of Ephx2 that encodes soluble epoxide hydrolase (sEH) to degrade epoxyeicosatrienic acids (EETs).	eets	151-155	epoxide hydrolase 2	Homo sapiens	109-112
33337352-1	2021	This study aimed to investigate the effects of arachidonic acid metabolite epoxyeicosatrienoic acid (EETs) in the apoptosis of endothelial cells induced by tumor necrosis factor-alpha (TNF-alpha).	eets	101-105	tumor necrosis factor	Homo sapiens	185-194
32736189-2	2020	Epoxyeicosatrienoic acids (EETs) are endogenous anti-inflammatory compounds, which are quickly converted by the soluble epoxide hydrolase (sEH) enzyme into a less active form with decreased biological effects.	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	112-137
33456570-2	2021	Lack of 12/15LOX dampens proinflammatory mediator 12-(S)-hydroxyeicosatetraenoic acid (12-(S)-HETE), improves post-MI survival, through the biosynthesis of endogenous mediators epoxyeicosatrienoic acids (EETs; cypoxins) to resolve post-MI inflammation.	eets	204-208	arachidonate 15-lipoxygenase	Mus musculus	8-16
33456570-4	2021	Therefore, we determined the role of EETs in macrophage-specific receptor activation in facilitating cardiac repair in 12/15LOX deficient mice experiencing HF.	eets	37-41	arachidonate 15-lipoxygenase	Mus musculus	119-127
33437370-0	2020	CYP2J2 promotes the development of hepatocellular carcinoma by increasing the EETs production to improve HIF-1alpha stability.	eets	78-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-115
33437370-1	2020	OBJECTIVE: This study aimed to explore the function and mechanism of Cytochrome P450 2J2 (CYP2J2) epoxygenase and epoxyeicosatrienoic acids (EETs) in the malignant development of hepatocellular carcinoma (HCC).	eets	141-145	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	69-88
33437370-1	2020	OBJECTIVE: This study aimed to explore the function and mechanism of Cytochrome P450 2J2 (CYP2J2) epoxygenase and epoxyeicosatrienoic acids (EETs) in the malignant development of hepatocellular carcinoma (HCC).	eets	141-145	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	90-96
33437370-6	2020	Finally, xenograft experiments were established to investigate the function of CYP2J2-EETs metabolism in HCC tumorigenesis in vivo.	eets	86-90	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	79-85
33255197-2	2020	The substrate-specific hydrolase activity of sEH converts epoxyeicosatrienoic acids (EETs) to less bioactive dihydroxyeicosatrienoic acids.	eets	85-89	epoxide hydrolase 2	Homo sapiens	45-48
33239900-3	2020	Giving the importance of epoxyeicosatrienoic acids (EETs) in kidney health, we aimed to study the association between two SNPs in the genes controlling synthesis and degradation of EETs (CYP2J2 rs2280275 and EPHX2 rs751141 respectively) and susceptibility of type 2 diabetes mellitus (T2DM) patients to develop DN.	eets	52-56	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	187-193
33239900-3	2020	Giving the importance of epoxyeicosatrienoic acids (EETs) in kidney health, we aimed to study the association between two SNPs in the genes controlling synthesis and degradation of EETs (CYP2J2 rs2280275 and EPHX2 rs751141 respectively) and susceptibility of type 2 diabetes mellitus (T2DM) patients to develop DN.	eets	181-185	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	187-193
33239900-3	2020	Giving the importance of epoxyeicosatrienoic acids (EETs) in kidney health, we aimed to study the association between two SNPs in the genes controlling synthesis and degradation of EETs (CYP2J2 rs2280275 and EPHX2 rs751141 respectively) and susceptibility of type 2 diabetes mellitus (T2DM) patients to develop DN.	eets	181-185	epoxide hydrolase 2	Homo sapiens	208-213
33095237-7	2020	CYP enzymes produce two types of eicosanoid products: EDHF vasodilator epoxyeicosatrienoic acids (EETs) and the vasoconstrictor 20-HETE.	eets	98-102	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
33312058-2	2020	Soluble epoxide hydrolase (sEH) catalyses the degradation of EETs to less biologically active dihydroxyeicosatrienoic acids.	eets	61-65	epoxide hydrolase 2	Homo sapiens	0-25
33312058-2	2020	Soluble epoxide hydrolase (sEH) catalyses the degradation of EETs to less biologically active dihydroxyeicosatrienoic acids.	eets	61-65	epoxide hydrolase 2	Homo sapiens	27-30
32767848-2	2021	Epoxyeicosatrienoic acids (EETs) are vasodilators; their actions are potentiated by soluble epoxide hydrolase (sEH) inhibition.	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	84-109
32767848-2	2021	Epoxyeicosatrienoic acids (EETs) are vasodilators; their actions are potentiated by soluble epoxide hydrolase (sEH) inhibition.	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	111-114
33437370-0	2020	CYP2J2 promotes the development of hepatocellular carcinoma by increasing the EETs production to improve HIF-1alpha stability.	eets	78-82	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
32452554-2	2020	We have reported that blocking the degradation of EETs with a soluble epoxide hydrolase (sEH) inhibitor protects mice from lipopolysaccharide (LPS)-induced acute lung injury (ALI).	eets	50-54	epoxide hydrolase 2, cytoplasmic	Mus musculus	62-87
32452554-2	2020	We have reported that blocking the degradation of EETs with a soluble epoxide hydrolase (sEH) inhibitor protects mice from lipopolysaccharide (LPS)-induced acute lung injury (ALI).	eets	50-54	epoxide hydrolase 2, cytoplasmic	Mus musculus	89-92
32452554-8	2020	Importantly, four EETs (5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET) inhibited the activation of NLRP3 inflammasome induced by LPS + ATP or LPS + nigericin in macrophages in various degree.	eets	18-22	NLR family, pyrin domain containing 3	Mus musculus	96-101
32736189-2	2020	Epoxyeicosatrienoic acids (EETs) are endogenous anti-inflammatory compounds, which are quickly converted by the soluble epoxide hydrolase (sEH) enzyme into a less active form with decreased biological effects.	eets	27-31	epoxide hydrolase 2	Rattus norvegicus	139-142
32461186-8	2020	Moreover, mounting evidence has revealed that EETs exert anti-inflammatory effects by inhibiting the expression of vascular adhesion molecules, activating NFkappaB, inflammatory cytokines secretion and COX-2 gene induction.	eets	46-50	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	202-207
33475089-1	2020	Stabilization of epoxyeicosatrienoic acids (EETs) levels via soluble epoxide hydrolase (sEH) deletion or its pharmacological inhibition have been shown to have beneficial effects on inflammation, ischemia, hypertension and diabetes.	eets	44-48	epoxide hydrolase 2	Rattus norvegicus	61-86
32903307-1	2020	Soluble epoxide hydrolase (sEH) is responsible for rapid degradation of 14, 15-EET, which is one of the isomers of EETs and plays an important role in cardiovascular diseases.	eets	115-119	epoxide hydrolase 2	Homo sapiens	0-25
32903307-1	2020	Soluble epoxide hydrolase (sEH) is responsible for rapid degradation of 14, 15-EET, which is one of the isomers of EETs and plays an important role in cardiovascular diseases.	eets	115-119	epoxide hydrolase 2	Homo sapiens	27-30
32294527-1	2020	Epoxyeicosatrienoic acids (EETs) are synthetized from arachidonic acid by the action of members of the CYP2C and CYP2J subfamilies of cytochrome P450 (CYPs).	eets	27-31	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	103-108
32114358-1	2020	Arachidonic acid can be metabolized to prostaglandins and epoxyeicosatrienoic acids (EETs) by cyclooxygenase-2 (COX-2) and cytochrome P450 (CYP), respectively.	eets	85-89	prostaglandin-endoperoxide synthase 2	Mus musculus	94-110
32114358-1	2020	Arachidonic acid can be metabolized to prostaglandins and epoxyeicosatrienoic acids (EETs) by cyclooxygenase-2 (COX-2) and cytochrome P450 (CYP), respectively.	eets	85-89	prostaglandin-endoperoxide synthase 2	Mus musculus	112-117
32001002-3	2020	Soluble epoxide hydrolase (sEH) is an enzyme that degrades epoxyeicosatrienoic acids (EETs), which have multiple protective effects on vascular structure and functions.	eets	86-90	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
31150667-3	2020	Our pharmacological experiments suggested that Nax signals led to activation of neurons bearing TRPV4 by using epoxyeicosatrienoic acids (EETs) as gliotransmitters to stimulate water intake.	eets	138-142	sodium channel, voltage-gated, type VII, alpha	Mus musculus	47-50
31150667-3	2020	Our pharmacological experiments suggested that Nax signals led to activation of neurons bearing TRPV4 by using epoxyeicosatrienoic acids (EETs) as gliotransmitters to stimulate water intake.	eets	138-142	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	96-101
31150667-8	2020	Double staining revealed that Nax-positive cells also expressed Cyp2c44, a cytochrome P450 epoxygenase, to generate EETs.	eets	116-120	sodium channel, voltage-gated, type VII, alpha	Mus musculus	30-33
31150667-8	2020	Double staining revealed that Nax-positive cells also expressed Cyp2c44, a cytochrome P450 epoxygenase, to generate EETs.	eets	116-120	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	64-71
31318834-3	2020	N-[1-(1-oxopropyl)-4-piperidinyl]-N"-[4-(trifluoromethoxy)phenyl)-urea (TPPU) is an inhibitor of soluble epoxide hydrolase (sEH), which can rapidly hydrolyze epoxyeicosatrienoic acids (EETs) to the bio-inactive dihydroxyeicosatrienoic acids (DHETs).	eets	185-189	epoxide hydrolase 2, cytoplasmic	Mus musculus	97-122
32439839-2	2020	Soluble epoxide hydrolase (sEH) is an enzyme that can hydrolyze epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids (EpFAs) into the less biologically active metabolites.	eets	91-95	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
32439839-2	2020	Soluble epoxide hydrolase (sEH) is an enzyme that can hydrolyze epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids (EpFAs) into the less biologically active metabolites.	eets	91-95	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
32001002-3	2020	Soluble epoxide hydrolase (sEH) is an enzyme that degrades epoxyeicosatrienoic acids (EETs), which have multiple protective effects on vascular structure and functions.	eets	86-90	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
31666457-5	2019	The elevation of EETs results in a decrease of class A scavenger receptor (SR-A) expression via downregulation of activator protein 1 (AP-1) expression.	eets	17-21	macrophage scavenger receptor 1	Mus musculus	75-79
32308747-7	2020	Decrease mRNA expression of Cyp2j9, Cyp2j6, and Cyp2j5 was observed, which metabolize ARA into epoxyeicosatrienoic acids (EETs).	eets	122-126	cytochrome P450, family 2, subfamily j, polypeptide 9	Mus musculus	28-34
32308747-7	2020	Decrease mRNA expression of Cyp2j9, Cyp2j6, and Cyp2j5 was observed, which metabolize ARA into epoxyeicosatrienoic acids (EETs).	eets	122-126	cytochrome P450, family 2, subfamily j, polypeptide 6	Mus musculus	36-42
32308747-7	2020	Decrease mRNA expression of Cyp2j9, Cyp2j6, and Cyp2j5 was observed, which metabolize ARA into epoxyeicosatrienoic acids (EETs).	eets	122-126	cytochrome P450, family 2, subfamily j, polypeptide 5	Mus musculus	48-54
31666457-5	2019	The elevation of EETs results in a decrease of class A scavenger receptor (SR-A) expression via downregulation of activator protein 1 (AP-1) expression.	eets	17-21	jun proto-oncogene	Mus musculus	114-133
31666457-5	2019	The elevation of EETs results in a decrease of class A scavenger receptor (SR-A) expression via downregulation of activator protein 1 (AP-1) expression.	eets	17-21	jun proto-oncogene	Mus musculus	135-139
30716359-3	2019	Recently, enhancing the concentration of epoxyeicosatrienoic acids (EETs) through blocking their hydrolytic degradation by soluble epoxide hydrolase (sEH) has been applied towards reducing the long-term damage associated with central neurologic insults.	eets	68-72	epoxide hydrolase 2	Homo sapiens	123-148
31415769-3	2019	Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP) epoxygenase-derived metabolites of arachidonic acid, protecting against diabetes and DN.	eets	27-31	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	37-52
31415769-3	2019	Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP) epoxygenase-derived metabolites of arachidonic acid, protecting against diabetes and DN.	eets	27-31	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	54-57
31271766-1	2019	Cytochrome P450 (CYP) epoxygenases and their metabolic products, epoxyeicosatrienoic acids (EETs), have been proposed as important therapeutic targets in the brain.	eets	92-96	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	17-20
31306370-3	2019	Of interest, cytochrome P450 2J (CYP2J) and soluble epoxide hydrolase (sEH) are known to control the maintenance of cardiovascular health through the regulation of cardioprotective epoxyeicosatrienoic acids (EETs) and its less active products, dihydroxyeicosatrienoic acids (DHETs).	eets	208-212	epoxide hydrolase 2	Homo sapiens	44-69
31306370-3	2019	Of interest, cytochrome P450 2J (CYP2J) and soluble epoxide hydrolase (sEH) are known to control the maintenance of cardiovascular health through the regulation of cardioprotective epoxyeicosatrienoic acids (EETs) and its less active products, dihydroxyeicosatrienoic acids (DHETs).	eets	208-212	epoxide hydrolase 2	Homo sapiens	71-74
31306370-7	2019	The modulation in EETs and DHETs was attributed to the increase of sEH and the decrease of CYP2J.	eets	18-22	epoxide hydrolase 2	Homo sapiens	67-70
30988740-4	2019	Epoxyeicosatrienoic acids (EETs) are natural anti-inflammatory factors and angiogenic mediators degraded by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	108-133
30988740-4	2019	Epoxyeicosatrienoic acids (EETs) are natural anti-inflammatory factors and angiogenic mediators degraded by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	135-138
31002701-1	2019	Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH).	eets	27-31	epoxide hydrolase 2	Homo sapiens	142-147
31002701-1	2019	Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH).	eets	27-31	epoxide hydrolase 2	Homo sapiens	149-168
31002701-1	2019	Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH).	eets	27-31	epoxide hydrolase 2	Homo sapiens	205-208
30789748-2	2019	Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids, attenuating their cardiovascular protective effects.	eets	70-74	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
30789748-2	2019	Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids, attenuating their cardiovascular protective effects.	eets	70-74	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
31622444-1	2019	Cytochrome P450 (CYP) enzymes metabolize arachidonic acid to vasoactive eicosanoids such as epoxyeicosatrienoic acids (EETs) and 20-Hydroxyeicosatetraenoic acid (20-HETE), whilst soluble epoxide hydrolase, encoded by the EPHX2 gene, is in charge of EETs degradation.	eets	119-123	epoxide hydrolase 2	Homo sapiens	221-226
31214021-12	2019	In vitro data showed that epoxyeicosatrienoic acid (EETs), epoxide metabolites of arachidonic acid, decreased inflammatory cytokines, IL-6 and TNF-alpha, and reduced cytotoxicity in canine chondrocytes challenged with IL1beta to simulate an arthritic environment.	eets	52-56	interleukin 6	Canis lupus familiaris	134-138
31214021-12	2019	In vitro data showed that epoxyeicosatrienoic acid (EETs), epoxide metabolites of arachidonic acid, decreased inflammatory cytokines, IL-6 and TNF-alpha, and reduced cytotoxicity in canine chondrocytes challenged with IL1beta to simulate an arthritic environment.	eets	52-56	tumor necrosis factor	Canis lupus familiaris	143-152
31214021-12	2019	In vitro data showed that epoxyeicosatrienoic acid (EETs), epoxide metabolites of arachidonic acid, decreased inflammatory cytokines, IL-6 and TNF-alpha, and reduced cytotoxicity in canine chondrocytes challenged with IL1beta to simulate an arthritic environment.	eets	52-56	interleukin 1 beta	Canis lupus familiaris	218-225
30716359-3	2019	Recently, enhancing the concentration of epoxyeicosatrienoic acids (EETs) through blocking their hydrolytic degradation by soluble epoxide hydrolase (sEH) has been applied towards reducing the long-term damage associated with central neurologic insults.	eets	68-72	epoxide hydrolase 2	Homo sapiens	150-153
30728778-2	2019	Previous studies have shown that increasing kidney epoxyeicosatrienoic acids (EETs) by blocking soluble epoxide hydrolase (sEH), an enzyme responsible for EETs degradation, improves the survival rate in CHF induced by aorto-caval fistula (ACF) and attenuates CKD progression.	eets	78-82	epoxide hydrolase 2	Rattus norvegicus	96-121
30885203-1	2019	BACKGROUND: This pathophysiological study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes the vasodilator and anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), contributes to conduit artery endothelial dysfunction in type 2 diabetes.	eets	188-192	epoxide hydrolase 2	Homo sapiens	72-97
30885203-1	2019	BACKGROUND: This pathophysiological study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes the vasodilator and anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), contributes to conduit artery endothelial dysfunction in type 2 diabetes.	eets	188-192	epoxide hydrolase 2	Homo sapiens	99-102
30804206-6	2019	Also, administration of an sEH inhibitor, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea, significantly attenuated the HFD-caused renal injury, decreased renal sEH consistently at mRNA and protein levels, modified the renal levels of sEH-mediated epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids (DHETs) as expected, and increased renal Pax2 and Ampk at mRNA and/or protein levels.	eets	286-290	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
30644034-5	2019	We found that TPPU and the sEH substrate epoxyeicosatrienoic acids (EETs) protected PC12 cells from the CORT-induced injury by increasing cell viability and inhibiting apoptosis.	eets	68-72	epoxide hydrolase 2	Rattus norvegicus	27-30
30644034-5	2019	We found that TPPU and the sEH substrate epoxyeicosatrienoic acids (EETs) protected PC12 cells from the CORT-induced injury by increasing cell viability and inhibiting apoptosis.	eets	68-72	cortistatin	Rattus norvegicus	104-108
30728778-2	2019	Previous studies have shown that increasing kidney epoxyeicosatrienoic acids (EETs) by blocking soluble epoxide hydrolase (sEH), an enzyme responsible for EETs degradation, improves the survival rate in CHF induced by aorto-caval fistula (ACF) and attenuates CKD progression.	eets	78-82	epoxide hydrolase 2	Rattus norvegicus	123-126
30047995-2	2018	Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) to less bioactive diols, and EETs have cardioprotective properties.	eets	70-74	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
31000184-1	2019	BACKGROUND: The cytochrome P-450 2J2 (CYP2J2) is known to be one of the major enzymes of epoxygenase pathway of arachidonic acid in extrahepatic tissues, which produces series of regioisomeric cis-epoxyeicosatrienoic acids (EETs) such as 5,6-, 8,9-, 11,12-, and 14,15-EETs.	eets	224-228	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	16-36
31000184-1	2019	BACKGROUND: The cytochrome P-450 2J2 (CYP2J2) is known to be one of the major enzymes of epoxygenase pathway of arachidonic acid in extrahepatic tissues, which produces series of regioisomeric cis-epoxyeicosatrienoic acids (EETs) such as 5,6-, 8,9-, 11,12-, and 14,15-EETs.	eets	224-228	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	38-44
31430751-1	2019	OBJECTIVE: We evaluated the hypothesis that the development of renal dysfunction and congestive heart failure (CHF) caused by volume overload in rats with angiotensin II (ANG II)-dependent hypertension is associated with altered renal vascular responsiveness to ANG II and to epoxyeicosatrienoic acids (EETs).	eets	303-307	angiotensinogen	Rattus norvegicus	155-169
31430751-1	2019	OBJECTIVE: We evaluated the hypothesis that the development of renal dysfunction and congestive heart failure (CHF) caused by volume overload in rats with angiotensin II (ANG II)-dependent hypertension is associated with altered renal vascular responsiveness to ANG II and to epoxyeicosatrienoic acids (EETs).	eets	303-307	angiotensinogen	Rattus norvegicus	171-177
30447256-1	2019	Soluble epoxide hydrolase (sEH) degrades epoxides of fatty acids including epoxyeicosatrienoic acid isomers (EETs), which are produced as metabolites of the cytochrome P450 branch of the arachidonic acid pathway.	eets	109-113	epoxide hydrolase 2	Homo sapiens	0-25
30447256-1	2019	Soluble epoxide hydrolase (sEH) degrades epoxides of fatty acids including epoxyeicosatrienoic acid isomers (EETs), which are produced as metabolites of the cytochrome P450 branch of the arachidonic acid pathway.	eets	109-113	epoxide hydrolase 2	Homo sapiens	27-30
30400671-2	2018	Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), vasoactive and natriuretic metabolites that contribute to blood pressure (BP) regulation.	eets	103-107	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-55
30400671-2	2018	Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), vasoactive and natriuretic metabolites that contribute to blood pressure (BP) regulation.	eets	103-107	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	57-63
30560267-4	2018	CYP450 epoxygenase metabolites epoxyeicosatrienoic acids (EETs) are mainly produced in renal microvessels.	eets	58-62	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-6
30420806-1	2018	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450 (CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH).	eets	27-31	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	73-88
30420806-1	2018	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450 (CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH).	eets	27-31	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	90-93
30420806-1	2018	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450 (CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	129-154
30420806-1	2018	Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450 (CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH).	eets	27-31	epoxide hydrolase 2, cytoplasmic	Mus musculus	156-159
29717935-2	2018	Epoxyeicosatrienoic acids (EETs), which are rapidly metabolized to dihydroxyeicosatrienoic acids by the soluble epoxide hydrolase (sEH), have multiple biological functions, including vasodilation, anti-inflammatory action, and others.	eets	27-31	epoxide hydrolase 2	Homo sapiens	104-129
29717935-2	2018	Epoxyeicosatrienoic acids (EETs), which are rapidly metabolized to dihydroxyeicosatrienoic acids by the soluble epoxide hydrolase (sEH), have multiple biological functions, including vasodilation, anti-inflammatory action, and others.	eets	27-31	epoxide hydrolase 2	Homo sapiens	131-134
30047995-2	2018	Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) to less bioactive diols, and EETs have cardioprotective properties.	eets	70-74	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
29851077-1	2018	BACKGROUND AND OBJECTIVE: Soluble epoxide hydrolase (sEH) is an enzyme in the arachidonate cascade which converts epoxy fatty acids (EpFAs), such as epoxyeicosatrienoic acids (EETs) produced by cytochrome P450 enzymes, to dihydroxy-eicosatrienoic acids.	eets	176-180	epoxide hydrolase 2, cytoplasmic	Mus musculus	26-51
30219518-12	2018	CONCLUSIONS: Our findings demonstrate that CYP2J2 improves cardiac function by increasing the concentration of circulating EETs, and boosting angiogenesis via the Jagged1/Notch1 signaling pathway in MI-induced heart failure.	eets	123-127	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	43-49
29851077-1	2018	BACKGROUND AND OBJECTIVE: Soluble epoxide hydrolase (sEH) is an enzyme in the arachidonate cascade which converts epoxy fatty acids (EpFAs), such as epoxyeicosatrienoic acids (EETs) produced by cytochrome P450 enzymes, to dihydroxy-eicosatrienoic acids.	eets	176-180	epoxide hydrolase 2, cytoplasmic	Mus musculus	53-56
29695613-1	2018	Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)-derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome P450 2J2 (CYP2J2).	eets	137-141	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	158-177
29960002-1	2018	CYP epoxygenases metabolize arachidonic acid into four regioisomers of epoxyeicosatrienoic acids (EETs) which are hydrolysed into their corresponding diols by soluble epoxide hydrolase (sEH).	eets	98-102	epoxide hydrolase 2	Homo sapiens	159-184
29960002-1	2018	CYP epoxygenases metabolize arachidonic acid into four regioisomers of epoxyeicosatrienoic acids (EETs) which are hydrolysed into their corresponding diols by soluble epoxide hydrolase (sEH).	eets	98-102	epoxide hydrolase 2	Homo sapiens	186-189
30066055-2	2018	CYP-derived AA epoxides, called epoxyeicosatrienoic acids (EETs), also promote the growth of tumor epithelia.	eets	59-63	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
29908721-1	2018	CYP2C and CYP2 J enzymes, commonly named as cytochrome P450 (CYP) epoxygenases, convert arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs), biologically active eicosanoids with many functions in organism.	eets	154-158	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
29908721-2	2018	EETs are rapidly hydrolysed to less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2	Homo sapiens	84-109
29908721-2	2018	EETs are rapidly hydrolysed to less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).	eets	0-4	epoxide hydrolase 2	Homo sapiens	111-114
30012669-5	2018	When injected into mice, NSCLC cells expressing CYP2C9*2 and CYP2C9*3 produced lower levels of EETs and developed fewer, smaller, and less vascularized tumors than cells expressing CYP2C9*1.	eets	95-99	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	48-54
30012669-5	2018	When injected into mice, NSCLC cells expressing CYP2C9*2 and CYP2C9*3 produced lower levels of EETs and developed fewer, smaller, and less vascularized tumors than cells expressing CYP2C9*1.	eets	95-99	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	61-67
30012669-5	2018	When injected into mice, NSCLC cells expressing CYP2C9*2 and CYP2C9*3 produced lower levels of EETs and developed fewer, smaller, and less vascularized tumors than cells expressing CYP2C9*1.	eets	95-99	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	61-67
30012669-7	2018	Purified CYP2C9*2 and CYP2C9*3 exhibited attenuated catalytic efficiency in producing EETs, primarily due to impaired reduction of these two variants by NADPH-P450 reductase.	eets	86-90	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	9-15
30012669-7	2018	Purified CYP2C9*2 and CYP2C9*3 exhibited attenuated catalytic efficiency in producing EETs, primarily due to impaired reduction of these two variants by NADPH-P450 reductase.	eets	86-90	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	22-28
29908721-1	2018	CYP2C and CYP2 J enzymes, commonly named as cytochrome P450 (CYP) epoxygenases, convert arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs), biologically active eicosanoids with many functions in organism.	eets	154-158	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	44-59
29695613-1	2018	Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)-derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome P450 2J2 (CYP2J2).	eets	137-141	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	179-185
29361048-2	2018	Cytochrome P(CYP)-450 enzymes metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acids.	eets	88-92	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	13-16
29966295-1	2018	Cytochrome P450 2J2 (CYP2J2) is a known arachidonic acid (AA) epoxygenase that mediates the formation of four bioactive regioisomers of cis-epoxyeicosatrienoic acids (EETs).	eets	167-171	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-19
29345370-3	2018	Soluble epoxide hydrolase (sEH) is known to play a pro-inflammatory role during inflammation by metabolizing anti-inflammatory epoxyeicosatrienoic acids (EETs) to pro-inflammatory diols.	eets	154-158	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-25
29345370-3	2018	Soluble epoxide hydrolase (sEH) is known to play a pro-inflammatory role during inflammation by metabolizing anti-inflammatory epoxyeicosatrienoic acids (EETs) to pro-inflammatory diols.	eets	154-158	epoxide hydrolase 2, cytoplasmic	Mus musculus	27-30
29966295-1	2018	Cytochrome P450 2J2 (CYP2J2) is a known arachidonic acid (AA) epoxygenase that mediates the formation of four bioactive regioisomers of cis-epoxyeicosatrienoic acids (EETs).	eets	167-171	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	21-27
29615440-1	2018	EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids.	eets	105-109	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-5
29615440-1	2018	EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids.	eets	105-109	epoxide hydrolase 2, cytoplasmic	Mus musculus	16-41
29615440-1	2018	EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids.	eets	105-109	epoxide hydrolase 2, cytoplasmic	Mus musculus	43-46