PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17328244-3	2007	NSAIDs tested significantly enhanced TNF-alpha release from lipopolysaccharide (LPS)-activated RAW264.7 cells at certain concentrations (fenoprofen, indomethacin, piroxicam, aceclofenac, diclofenac and sulindac) or in a dose-dependent manner (aspirin and phenylbutazone).	aceclofenac	174-185	tumor necrosis factor	Mus musculus	37-46
17557739-8	2007	In relation to the photoallergic activity of this drug, the interaction of aceclofenac with human serum albumin (HSA) has been studied through fluorescence spectroscopy.	aceclofenac	75-86	albumin	Homo sapiens	98-111
17022718-11	2006	The risk for digestive hemorrhage associated with the CYP2C9 genotype is particularly relevant when using aceclofenac, celecoxib, diclofenac, ibuprofen, indomethacin, lornoxicam, piroxicam, or naproxen.	aceclofenac	106-117	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	54-60
16709320-6	2006	Aceclofenac is an anti-inflammatory and analgesic drug with preferential COX-2 inhibition.	aceclofenac	0-11	prostaglandin-endoperoxide synthase 2	Homo sapiens	73-78
11950021-10	2002	ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects.	aceclofenac	0-6	interleukin 1 beta	Homo sapiens	59-67
15555568-2	2004	NAG-1 expression was increased by diclofenac, aceclofenac, indomethacin, ibuprofen, and sulindac sulfide, in the order of NAG-1 induction, but not by acetaminophen, piroxicam or NS-398.	aceclofenac	46-57	growth differentiation factor 15	Homo sapiens	0-5
12966366-0	2003	Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac.	aceclofenac	0-11	prostaglandin-endoperoxide synthase 1	Homo sapiens	19-35
15314506-6	2004	Among the traditional NSAIDs, the mode of action of aceclofenac has been recently clarified in that the compound was shown to elicit preferential inhibition of COX-2 as a result of limited but sustained biotransformation to diclofenac.	aceclofenac	52-63	prostaglandin-endoperoxide synthase 2	Homo sapiens	160-165
12966366-8	2003	Maximal plasma concentrations of diclofenac after oral administration of aceclofenac (0.39 micromol/L) or diclofenac (1.28 micromol/L) were sufficient for a greater than 97% inhibition of COX-2 (50% inhibitory concentration, 0.024 micromol/L) and a 46% (aceclofenac treatment) or 82% inhibition (diclofenac treatment) of COX-1 (50% inhibitory concentration, 0.43 micromol/L).	aceclofenac	73-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
12966366-9	2003	Moreover, ex vivo COX-1-dependent thromboxane B(2) synthesis was inhibited significantly less by aceclofenac than by diclofenac.	aceclofenac	97-108	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	18-23
12966366-11	2003	Although 100 mg aceclofenac yielded diclofenac concentrations substantially lower than 75 mg diclofenac, these were sufficient for a sustained block of COX-2 but caused a minor and shorter inhibition of COX-1 than 75 mg diclofenac.	aceclofenac	16-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
12966366-11	2003	Although 100 mg aceclofenac yielded diclofenac concentrations substantially lower than 75 mg diclofenac, these were sufficient for a sustained block of COX-2 but caused a minor and shorter inhibition of COX-1 than 75 mg diclofenac.	aceclofenac	16-27	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	203-208
12966366-12	2003	In conclusion, both COX-1-sparing and COX-2-inhibitory actions of aceclofenac may rest in its limited but sustained biotransformation to diclofenac.	aceclofenac	66-77	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	20-25
12966366-12	2003	In conclusion, both COX-1-sparing and COX-2-inhibitory actions of aceclofenac may rest in its limited but sustained biotransformation to diclofenac.	aceclofenac	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
11950021-10	2002	ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects.	aceclofenac	0-6	interleukin 6	Homo sapiens	79-83
11409489-7	2001	Aceclofenac inhibited COX-2 more potently than COX-1 (IC50: 3.0/7.3 microM).	aceclofenac	0-11	cytochrome c oxidase subunit II	Bos taurus	22-27
11764219-4	2001	We investigated the possible effects of 3 different nonsteroidal antiinflammatory drugs (NSAID; aceclofenac, piroxicam, aspirin) on IL-1Ra and NO production in human articular chondrocytes.	aceclofenac	96-107	interleukin 1 receptor antagonist	Homo sapiens	132-138
11764219-13	2001	In contrast to piroxicam and aspirin, aceclofenac 10 microg/ml and TNF-alpha 10 ng/ml increased almost 46 times the basal amount of IL-1Ra produced by OA chondrocytes.	aceclofenac	38-49	interleukin 1 receptor antagonist	Homo sapiens	132-138
11556519-8	2001	RESULTS: We have demonstrated that aceclofenac, 4"-hydroxyaceclofenac and diclofenac significantly decreased interleukin-6 production at concentrations ranged among 1 to 30 microM and fully blocked prostaglandin E2 synthesis by IL-1beta- or LPS-stimulated human chondrocytes.	aceclofenac	35-46	interleukin 6	Homo sapiens	109-122
11556519-8	2001	RESULTS: We have demonstrated that aceclofenac, 4"-hydroxyaceclofenac and diclofenac significantly decreased interleukin-6 production at concentrations ranged among 1 to 30 microM and fully blocked prostaglandin E2 synthesis by IL-1beta- or LPS-stimulated human chondrocytes.	aceclofenac	35-46	interleukin 1 beta	Homo sapiens	228-236
11556519-13	2001	In the whole blood test, aceclofenac and 4"-hydroxyaceclofenac weakly inhibited COX-1 with IC50 values superior to 100 microM, but decreased by 50% COX-2 activity at the concentration of 0.77 and 36 microM, respectively.	aceclofenac	25-36	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	80-85
11556519-13	2001	In the whole blood test, aceclofenac and 4"-hydroxyaceclofenac weakly inhibited COX-1 with IC50 values superior to 100 microM, but decreased by 50% COX-2 activity at the concentration of 0.77 and 36 microM, respectively.	aceclofenac	25-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
11523298-2	2001	Aceclofenac has an outstanding anti-inflammatory profile, involving besides a classical inhibition of prostaglandins E2, a decrease in the expression of several cytokines including interleukin 1 and tumor necrosis factor alpha.	aceclofenac	0-11	interleukin 1 alpha	Homo sapiens	181-226
10807502-5	2000	RESULTS: 4"-Hydroxy aceclofenac, a major metabolite of aceclofenac, down-regulated both basal and IL-1beta-induced production of proMMP-1 and proMMP-3 at a concentration sufficient to suppress PGE2 production without modulating proMMP-2 or TIMP-1, whereas aceclofenac itself had no marked effect on the production of proMMPs.	aceclofenac	20-31	interleukin 1 beta	Homo sapiens	98-106
10961715-7	2000	In conclusion, COX-2-COX-1 selectivity was demonstrated in vivo with the drugs aceclofenac, nabumetone, meloxicam, nimesulide, and paracetamol.	aceclofenac	79-90	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	15-20
10961715-7	2000	In conclusion, COX-2-COX-1 selectivity was demonstrated in vivo with the drugs aceclofenac, nabumetone, meloxicam, nimesulide, and paracetamol.	aceclofenac	79-90	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	21-26
10807502-5	2000	RESULTS: 4"-Hydroxy aceclofenac, a major metabolite of aceclofenac, down-regulated both basal and IL-1beta-induced production of proMMP-1 and proMMP-3 at a concentration sufficient to suppress PGE2 production without modulating proMMP-2 or TIMP-1, whereas aceclofenac itself had no marked effect on the production of proMMPs.	aceclofenac	20-31	TIMP metallopeptidase inhibitor 1	Homo sapiens	240-246
10807502-5	2000	RESULTS: 4"-Hydroxy aceclofenac, a major metabolite of aceclofenac, down-regulated both basal and IL-1beta-induced production of proMMP-1 and proMMP-3 at a concentration sufficient to suppress PGE2 production without modulating proMMP-2 or TIMP-1, whereas aceclofenac itself had no marked effect on the production of proMMPs.	aceclofenac	55-66	interleukin 1 beta	Homo sapiens	98-106
10807502-5	2000	RESULTS: 4"-Hydroxy aceclofenac, a major metabolite of aceclofenac, down-regulated both basal and IL-1beta-induced production of proMMP-1 and proMMP-3 at a concentration sufficient to suppress PGE2 production without modulating proMMP-2 or TIMP-1, whereas aceclofenac itself had no marked effect on the production of proMMPs.	aceclofenac	55-66	TIMP metallopeptidase inhibitor 1	Homo sapiens	240-246
8730134-4	1996	RESULTS: Aceclofenac induced a dramatic decrease of L-selectin expression, whereas a moderate and slight decrement of CD43 and ICAM-3 expression was also observed.	aceclofenac	9-20	selectin L	Homo sapiens	52-62
9751102-8	1998	Aceclofenac, diclofenac, and indomethacin, but not piroxicam, were able to inhibit PBL adhesion to HUVEC or rVCAM-1.	aceclofenac	0-11	vascular cell adhesion molecule 1	Rattus norvegicus	108-115
9751102-10	1998	On T lymphoblasts and SFL, mostly CD45RO+ cells, the expression of the beta1 activation-dependent epitope detected by HUTS21 MAb was significantly decreased by aceclofenac, diclofenac, and indomethacin.	aceclofenac	160-171	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	71-76
9226412-3	1997	Aceclofenac inhibited interleukin-1beta-induced prostaglandin E2 production by human rheumatoid synovial cells, but had no inhibitory effect on cyclooxygenase-1 or cyclooxygenase-2 activities by itself.	aceclofenac	0-11	interleukin 1 beta	Homo sapiens	22-39
9226412-4	1997	We also observed that part of the aceclofenac was converted into diclofenac, the cyclooxygenase-1 and cyclooxygenase-2 inhibitor, when aceclofenac was incubated with human rheumatoid synovial cells.	aceclofenac	34-45	prostaglandin-endoperoxide synthase 1	Homo sapiens	81-97
9226412-4	1997	We also observed that part of the aceclofenac was converted into diclofenac, the cyclooxygenase-1 and cyclooxygenase-2 inhibitor, when aceclofenac was incubated with human rheumatoid synovial cells.	aceclofenac	34-45	prostaglandin-endoperoxide synthase 2	Homo sapiens	102-118
9226412-4	1997	We also observed that part of the aceclofenac was converted into diclofenac, the cyclooxygenase-1 and cyclooxygenase-2 inhibitor, when aceclofenac was incubated with human rheumatoid synovial cells.	aceclofenac	135-146	prostaglandin-endoperoxide synthase 1	Homo sapiens	81-97
9226412-4	1997	We also observed that part of the aceclofenac was converted into diclofenac, the cyclooxygenase-1 and cyclooxygenase-2 inhibitor, when aceclofenac was incubated with human rheumatoid synovial cells.	aceclofenac	135-146	prostaglandin-endoperoxide synthase 2	Homo sapiens	102-118
9773153-11	1998	aceclofenac (Ace); 9.	aceclofenac	0-11	angiotensin I converting enzyme	Rattus norvegicus	13-16
9773153-35	1998	CONCLUSIONS: COX-2-COX-1 selectivity was demonstrated "in vivo" in aceclofenac, meloxicam, nabumetone, nimesulide and paracetamol.	aceclofenac	67-78	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	13-18
9773153-35	1998	CONCLUSIONS: COX-2-COX-1 selectivity was demonstrated "in vivo" in aceclofenac, meloxicam, nabumetone, nimesulide and paracetamol.	aceclofenac	67-78	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	19-24
8853164-2	1996	Treatment with aceclofenac was effective in improving the Ritchie articular index (predetermined primary end point), duration of morning stiffness, joint swelling, ARA functional class, patient"s and physician"s global assessments, and pain.	aceclofenac	15-26	ATP binding cassette subfamily C member 6	Homo sapiens	164-167
8730134-6	1996	Cell adhesion assays, performed under nonstatic conditions, revealed that aceclofenac significantly diminished the L-selectin dependent neutrophil adhesion to endothelial cells.	aceclofenac	74-85	selectin L	Homo sapiens	115-125
8730134-7	1996	Neutrophil aggregation induced with anti-CD43 Mab was also significantly inhibited by aceclofenac.	aceclofenac	86-97	sialophorin	Homo sapiens	41-45
22459452-3	2012	Hence there are chances of drug-drug interaction because modulations of isoenzymes involved in metabolism of phenytoin and aceclofenac are CYP2C9/10 and CYP2C19.	aceclofenac	123-134	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	139-145
34968019-6	2021	The most pronounced clinical effect (PCFS) was obtained after 1 mth of therapy with vinpocetine and 20 days with aceclofenac (NRS-P).	aceclofenac	113-124	sphingolipid transporter 1 (putative)	Homo sapiens	126-129
27839691-2	2016	Aceclofenac is converted to 4"-hydroxyaceclofenac and diclofenac via CYP2C9-mediated hydroxylation and hydrolysis, respectively.	aceclofenac	0-11	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	69-75
34616297-1	2021	Aceclofenac (ACE), a cyclooxygenase-2 inhibitor, is the derivative of the diclofenac group that has been in use for the symptomatic treatment of systemic inflammatory autoimmune disease, rheumatoid arthritis (RA).	aceclofenac	0-11	angiotensin I converting enzyme	Homo sapiens	13-16
34616297-1	2021	Aceclofenac (ACE), a cyclooxygenase-2 inhibitor, is the derivative of the diclofenac group that has been in use for the symptomatic treatment of systemic inflammatory autoimmune disease, rheumatoid arthritis (RA).	aceclofenac	0-11	prostaglandin-endoperoxide synthase 2	Homo sapiens	21-37
26668672-2	2015	Our study was designed to investigate the interaction between aceclofenac and bovine serum albumin (BSA) using fluorescence spectroscopy at different temperatures (298 and 308 K).	aceclofenac	62-73	albumin	Homo sapiens	85-98
25403255-1	2015	The mutual prodrugs of aceclofenac with various naturally available antioxidants; menthol, thymol, eugenol, guiacol and vanillin have been synthesized by the DCC coupling method, purified and characterized by spectral data, as well as, partition coefficient, solubility and hydrolytic studies.	aceclofenac	23-34	DCC netrin 1 receptor	Homo sapiens	158-161
22459452-3	2012	Hence there are chances of drug-drug interaction because modulations of isoenzymes involved in metabolism of phenytoin and aceclofenac are CYP2C9/10 and CYP2C19.	aceclofenac	123-134	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	153-160
22171305-1	2011	Aceclofenac has been shown to have potent analgesic and anti-inflammatory activities similar to indomethacin and diclofenac, and due to its preferential Cox-2 blockade, it has a better safety than conventional Non steroidal anti-inflammatory drug (NSAIDs) with respect to adverse effect on gastrointestinal and cardiovascular systems.	aceclofenac	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
22171305-2	2011	Aceclofenac is superior from other NSAIDs as it has selectivity for Cox-2, a beneficial Cox inhibitor is well tolerated, has better Gastrointestinal (GI) tolerability and improved cardiovascular safety when compared with other selective Cox-2 inhibitor.	aceclofenac	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
22171305-2	2011	Aceclofenac is superior from other NSAIDs as it has selectivity for Cox-2, a beneficial Cox inhibitor is well tolerated, has better Gastrointestinal (GI) tolerability and improved cardiovascular safety when compared with other selective Cox-2 inhibitor.	aceclofenac	0-11	cytochrome c oxidase subunit 8A	Homo sapiens	68-71
22171305-2	2011	Aceclofenac is superior from other NSAIDs as it has selectivity for Cox-2, a beneficial Cox inhibitor is well tolerated, has better Gastrointestinal (GI) tolerability and improved cardiovascular safety when compared with other selective Cox-2 inhibitor.	aceclofenac	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
19444620-0	2009	Preparation and characterization of co-grinded mixtures of aceclofenac and neusilin US2 for dissolution enhancement of aceclofenac.	aceclofenac	119-130	usherin	Homo sapiens	84-87
19422321-1	2009	Polymorphisms in CYP2C8 and CYP2C9 are common in all the human populations and many CYP2C8 and CYP2C9 gene variations cause decreased enzyme activity towards the NSAIDs aceclofenac, celecoxib, diclofenac, ibuprofen, indomethazine, lornoxicam, meloxicam, naproxen, piroxicam, tenoxicam and valdecoxib.	aceclofenac	169-180	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	17-23
19422321-1	2009	Polymorphisms in CYP2C8 and CYP2C9 are common in all the human populations and many CYP2C8 and CYP2C9 gene variations cause decreased enzyme activity towards the NSAIDs aceclofenac, celecoxib, diclofenac, ibuprofen, indomethazine, lornoxicam, meloxicam, naproxen, piroxicam, tenoxicam and valdecoxib.	aceclofenac	169-180	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	28-34
19422321-1	2009	Polymorphisms in CYP2C8 and CYP2C9 are common in all the human populations and many CYP2C8 and CYP2C9 gene variations cause decreased enzyme activity towards the NSAIDs aceclofenac, celecoxib, diclofenac, ibuprofen, indomethazine, lornoxicam, meloxicam, naproxen, piroxicam, tenoxicam and valdecoxib.	aceclofenac	169-180	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	84-90
19422321-1	2009	Polymorphisms in CYP2C8 and CYP2C9 are common in all the human populations and many CYP2C8 and CYP2C9 gene variations cause decreased enzyme activity towards the NSAIDs aceclofenac, celecoxib, diclofenac, ibuprofen, indomethazine, lornoxicam, meloxicam, naproxen, piroxicam, tenoxicam and valdecoxib.	aceclofenac	169-180	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	95-101