PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24409316-9	2014	Although SLC2A9-L has a putative di-leucine motif at 33th and 34th leucine, deletion of the motif or replacement of leucine did not affect its subcellular localization.	di-leucine	33-43	solute carrier family 2 member 9	Homo sapiens	9-15
25375179-9	2014	ZIP12 also possesses many putative di-leucine and tyrosine motifs often associated with intracellular trafficking, which may control cellular zinc uptake activity through the localization of ZIP12 within the cell.	di-leucine	35-45	solute carrier family 39 member 12	Homo sapiens	0-5
25375179-9	2014	ZIP12 also possesses many putative di-leucine and tyrosine motifs often associated with intracellular trafficking, which may control cellular zinc uptake activity through the localization of ZIP12 within the cell.	di-leucine	35-45	solute carrier family 39 member 12	Homo sapiens	191-196
18625303-0	2008	Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosis.	di-leucine	26-36	solute carrier family 12 member 5	Homo sapiens	78-82
23830917-0	2013	A C-terminal di-leucine motif controls plasma membrane expression of PMCA4b.	di-leucine	13-23	ATPase plasma membrane Ca2+ transporting 4	Homo sapiens	69-75
23350547-4	2013	In this study, a yeast three-hybrid system revealed that the NPC1 cytoplasmic tail directly interacts with the clathrin adaptor protein AP-1 via its acidic/di-leucine motif.	di-leucine	156-166	NPC intracellular cholesterol transporter 1	Homo sapiens	61-65
23350547-4	2013	In this study, a yeast three-hybrid system revealed that the NPC1 cytoplasmic tail directly interacts with the clathrin adaptor protein AP-1 via its acidic/di-leucine motif.	di-leucine	156-166	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-140
23109336-7	2012	Moreover, the combination of the lack of ubiquitination at Lys-501 and the disruption of the di-leucine motif (BACE1LLAA/KR) produces additive effects on BACE1 stabilization and defective internalization.	di-leucine	93-103	beta-secretase 1	Homo sapiens	111-116
23109336-9	2012	Our studies have elucidated a differential role for the di-leucine motif and ubiquitination at Lys-501 in BACE1 endocytosis, trafficking, and degradation and suggest the involvement of multiple adaptor molecules.	di-leucine	56-66	beta-secretase 1	Homo sapiens	106-111
22707720-4	2012	Our findings indicate that TbetaRI is targeted for constitutive clathrin-mediated endocytosis via a di-leucine (Leu(180)-Ile(181)) signal and an acidic cluster motif.	di-leucine	100-110	transforming growth factor beta receptor 1	Homo sapiens	27-34
22253225-4	2012	Using the paralogous Arabidopsis thaliana inositol transporters INT1 (tonoplast) and INT4 (plasma membrane), we performed domain swapping and mutational analyses and identified a C-terminal di-leucine motif responsible for the sorting of higher plant INT1-type transporters to the tonoplast in Arabidopsis mesophyll protoplasts.	di-leucine	190-200	inositol transporter 1	Arabidopsis thaliana	64-68
22253225-4	2012	Using the paralogous Arabidopsis thaliana inositol transporters INT1 (tonoplast) and INT4 (plasma membrane), we performed domain swapping and mutational analyses and identified a C-terminal di-leucine motif responsible for the sorting of higher plant INT1-type transporters to the tonoplast in Arabidopsis mesophyll protoplasts.	di-leucine	190-200	inositol transporter 4	Arabidopsis thaliana	85-89
22253225-4	2012	Using the paralogous Arabidopsis thaliana inositol transporters INT1 (tonoplast) and INT4 (plasma membrane), we performed domain swapping and mutational analyses and identified a C-terminal di-leucine motif responsible for the sorting of higher plant INT1-type transporters to the tonoplast in Arabidopsis mesophyll protoplasts.	di-leucine	190-200	inositol transporter 1	Arabidopsis thaliana	251-255
24129190-0	2013	Involvement of a di-leucine motif in targeting of ABCC1 to the basolateral plasma membrane of polarized epithelial cells.	di-leucine	17-27	ATP binding cassette subfamily C member 1	Homo sapiens	50-55
24129190-3	2013	Comparison of the CLD1 amino acid sequences from ABCC1 to ABCC2 revealed that ABCC1 possesses a characteristic sequence, E(295)EVEALI(301), which is comprised of a cluster of acidic glutamate residues followed by a di-leucine motif.	di-leucine	215-225	claudin 1	Homo sapiens	18-22
24129190-3	2013	Comparison of the CLD1 amino acid sequences from ABCC1 to ABCC2 revealed that ABCC1 possesses a characteristic sequence, E(295)EVEALI(301), which is comprised of a cluster of acidic glutamate residues followed by a di-leucine motif.	di-leucine	215-225	ATP binding cassette subfamily C member 1	Homo sapiens	78-83
24129190-7	2013	Therefore, a di-leucine motif within the CLD1 is a basolateral targeting determinant of ABCC1.	di-leucine	13-23	claudin 1	Homo sapiens	41-45
24129190-7	2013	Therefore, a di-leucine motif within the CLD1 is a basolateral targeting determinant of ABCC1.	di-leucine	13-23	ATP binding cassette subfamily C member 1	Homo sapiens	88-93
23105100-0	2012	Multiple evolutionarily conserved Di-leucine like motifs in the carboxyl terminus control the anterograde trafficking of NKCC2.	di-leucine	34-44	solute carrier family 12 member 1	Homo sapiens	121-126
21815974-11	2011	We conclude that MOT2 is important for vacuolar molybdate export, an N-terminal di-leucine motif is critical for correct subcellular localisation of MOT2 and activity of this carrier is required for accumulation of molybdate in Arabidopsis seeds.	di-leucine	80-90	sulfate transmembrane transporter	Arabidopsis thaliana	149-153
21569545-0	2011	Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity.	di-leucine	28-38	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	108-111
21195069-5	2011	This was tested by truncating GHR after a di-leucine-based internalisation motif (GHR349).	di-leucine	42-52	growth hormone receptor	Homo sapiens	30-33
20550966-4	2010	From a yeast-2-hybrid screen, we identify the novel interactor, SIDL (for Shal Interactor of Di-Leucine Motif), as the first target protein reported to bind the highly conserved di-leucine motif (LL-motif) implicated in dendritic targeting.	di-leucine	93-103	Shaker cognate l	Drosophila melanogaster	74-78
20550966-4	2010	From a yeast-2-hybrid screen, we identify the novel interactor, SIDL (for Shal Interactor of Di-Leucine Motif), as the first target protein reported to bind the highly conserved di-leucine motif (LL-motif) implicated in dendritic targeting.	di-leucine	178-188	Shaker cognate l	Drosophila melanogaster	74-78
18625303-7	2008	By site-directed mutagenesis we define this novel KCC2 endocytic motif as a non-canonical di-leucine motif, (657)LLXXEE(662).	di-leucine	90-100	solute carrier family 12 member 5	Homo sapiens	50-54
17255961-3	2007	Here, we report the differential effects of Sec24 isoform-specific silencing on the transport of the membrane reporter protein ERGIC-53 (ER-Golgi intermediate compartment-53) carrying the cytosolic ER export signals di-phenylalanine, di-tyrosine, di-leucine, di-isoleucine, di-valine or terminal valine.	di-leucine	247-257	SEC24 homolog B, COPII coat complex component	Homo sapiens	44-49
18501205-5	2008	LPA1 possesses a number of motifs conserved among G protein-coupled receptors (GPCRs): a DRY-like motif, a PDZ domain, Ser/Thr predicted sites of phosphorylation, a di-leucine motif, double cysteines in the tail and conserved residues that stabilize structure and determine ligand binding.	di-leucine	165-175	lysophosphatidic acid receptor 1	Homo sapiens	0-4
18346468-0	2008	Role of the carboxyl terminal di-leucine in phosphorylation and internalization of C5a receptor.	di-leucine	30-40	complement C5a receptor 1	Homo sapiens	83-95
17643422-10	2007	Furthermore, we showed that the di-leucine motif 1010LL1011 within this region is essential in mediating EGF-induced rapid EGFR internalization independent of kinase activation.	di-leucine	32-42	epidermal growth factor receptor	Homo sapiens	123-127
17635580-6	2007	Substitutions of alanines for the di-leucine residues (LL148,149/AA) severely impaired the internalization of ZIP1 and subsequent protein degradation, leading to an accumulation of the mutant ZIP1 on the cell surface, as well as inside the cell.	di-leucine	34-44	solute carrier family 39 member 1	Homo sapiens	110-114
17635580-6	2007	Substitutions of alanines for the di-leucine residues (LL148,149/AA) severely impaired the internalization of ZIP1 and subsequent protein degradation, leading to an accumulation of the mutant ZIP1 on the cell surface, as well as inside the cell.	di-leucine	34-44	solute carrier family 39 member 1	Homo sapiens	192-196
17182531-7	2007	We propose that the FL motif in the COOH-terminal tail of NBC1 is essential for the targeting of NBC1 to the basolateral membrane but is distinct from the membrane-targeting di-leucine motif identified in other membrane proteins.	di-leucine	174-184	solute carrier family 4 member 4	Homo sapiens	58-62
17255961-3	2007	Here, we report the differential effects of Sec24 isoform-specific silencing on the transport of the membrane reporter protein ERGIC-53 (ER-Golgi intermediate compartment-53) carrying the cytosolic ER export signals di-phenylalanine, di-tyrosine, di-leucine, di-isoleucine, di-valine or terminal valine.	di-leucine	247-257	lectin, mannose binding 1	Homo sapiens	127-135
17255961-3	2007	Here, we report the differential effects of Sec24 isoform-specific silencing on the transport of the membrane reporter protein ERGIC-53 (ER-Golgi intermediate compartment-53) carrying the cytosolic ER export signals di-phenylalanine, di-tyrosine, di-leucine, di-isoleucine, di-valine or terminal valine.	di-leucine	247-257	lectin, mannose binding 1	Homo sapiens	137-173
17255961-4	2007	Knockdown of single Sec24 isoforms showed dependence of di-leucine-mediated transport on Sec24A, but transport mediated by the other signals was not affected.	di-leucine	56-66	SEC24 homolog B, COPII coat complex component	Homo sapiens	20-25
17255961-4	2007	Knockdown of single Sec24 isoforms showed dependence of di-leucine-mediated transport on Sec24A, but transport mediated by the other signals was not affected.	di-leucine	56-66	SEC24 homolog A, COPII coat complex component	Homo sapiens	89-95
17255961-6	2007	Double knockdown of Sec24B/C or Sec24B/D preferentially affected di-leucine-mediated transport, whereas knockdown of Sec24C/D affected di-isoleucine- and valine-mediated transport.	di-leucine	65-75	SEC24 homolog B, COPII coat complex component	Homo sapiens	20-26
17255961-6	2007	Double knockdown of Sec24B/C or Sec24B/D preferentially affected di-leucine-mediated transport, whereas knockdown of Sec24C/D affected di-isoleucine- and valine-mediated transport.	di-leucine	65-75	SEC24 homolog B, COPII coat complex component	Homo sapiens	32-38
17140399-5	2007	The colocalization of Nef with clathrin required the di-leucine motif essential for Nef binding to AP complexes and was independent of CD4 expression.	di-leucine	53-63	S100 calcium binding protein B	Homo sapiens	22-25
17140399-5	2007	The colocalization of Nef with clathrin required the di-leucine motif essential for Nef binding to AP complexes and was independent of CD4 expression.	di-leucine	53-63	S100 calcium binding protein B	Homo sapiens	84-87
17003106-0	2006	Role of the C-terminal di-leucine motif of 5-HT1A and 5-HT1B serotonin receptors in plasma membrane targeting.	di-leucine	23-33	5-hydroxytryptamine receptor 1A	Homo sapiens	43-49
16236769-3	2005	Here we characterize cis-acting targeting sequences in the LIN-12 intracellular domain and find that in addition to a di-leucine motif, serine/threonine residues are important for internalization and lysine residues are important for post-internalization trafficking and degradation.	di-leucine	118-128	lin-12/Notch intracellular domain	Caenorhabditis elegans	59-65
16274960-8	2006	Accordingly, we detect apical delivery of a gp130 mutant in which the di-leucine motif has been exchanged by two alanines (gp130LL/AA).	di-leucine	70-80	interleukin 6 cytokine family signal transducer	Canis lupus familiaris	44-49
16274960-9	2006	These findings indicate that the di-leucine motif which directs the internalization of the IL-6 receptor complex also mediates the basolateral sorting of the signal transducer gp130.	di-leucine	33-43	interleukin 6 cytokine family signal transducer	Canis lupus familiaris	176-181
16497227-7	2006	Finally, the mutagenesis of both di-leucine motifs abrogated lysosomal accumulation and resulted in cell-surface redistribution of mucolipin-1.	di-leucine	33-43	mucolipin TRP cation channel 1	Homo sapiens	131-142
16033761-4	2005	The carboxyl terminus of BACE contains a di-leucine-based signal for sorting of transmembrane proteins to endosomes and lysosomes.	di-leucine	41-51	beta-secretase 1	Homo sapiens	25-29
16033761-5	2005	In this study, we set out to determine whether BACE is degraded by the lysosomal pathway and whether the di-leucine motif is necessary for targeting BACE to the lysosomes.	di-leucine	105-115	beta-secretase 1	Homo sapiens	149-153
13679604-0	2003	The di-leucine motif in the cytoplasmic tail of CD4 is not required for binding to human immunodeficiency virus type 1 Nef, but is critical for CD4 down-modulation.	di-leucine	4-14	CD4 molecule	Homo sapiens	48-51
15215314-4	2004	The cytoplasmic domain of CD147 has basolateral sorting information but is devoid of well-characterized basolateral signals, such as tyrosine and di-leucine motifs.	di-leucine	146-156	basigin (Ok blood group)	Homo sapiens	26-31
14592735-0	2003	Presence of the di-leucine motif in the cytoplasmic tail of the pig FcRn alpha chain.	di-leucine	16-26	Fc gamma receptor and transporter	Sus scrofa	68-72
14592735-4	2003	Our sequence, along with a previous NCBI GenBank submission and five pig derived EST clones clearly demonstrate the presence of di-leucine motif in the cytoplasmic tail of the pig FcRn.	di-leucine	128-138	Fc gamma receptor and transporter	Sus scrofa	180-184
12900408-0	2003	Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the epidermal growth factor receptor trafficking.	di-leucine	101-111	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	32-37
12900408-0	2003	Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the epidermal growth factor receptor trafficking.	di-leucine	101-111	transcription factor AP-2 alpha	Homo sapiens	74-78
12900408-0	2003	Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the epidermal growth factor receptor trafficking.	di-leucine	101-111	epidermal growth factor receptor	Homo sapiens	125-157
12900408-7	2003	From these data, we propose that interactions of the EGF receptor with AP-2 mediated by the receptor 974YRAL and di-leucine motifs may contribute to beta2 tyrosine phosphorylation.	di-leucine	113-123	transcription factor AP-2 alpha	Homo sapiens	71-75
12900408-7	2003	From these data, we propose that interactions of the EGF receptor with AP-2 mediated by the receptor 974YRAL and di-leucine motifs may contribute to beta2 tyrosine phosphorylation.	di-leucine	113-123	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	149-154
16155254-6	2005	Mutating a di-leucine motif (L812L813) to a di-alanine changed the basolateral targeting of ClC-2 to an apical location.	di-leucine	11-21	chloride voltage-gated channel 2	Homo sapiens	92-97
16155254-8	2005	Basolateral targeting information is contained in a di-leucine motif (L812L813) within CBS-2 domain at the C-terminus of ClC-2.	di-leucine	52-62	chloride voltage-gated channel 2	Homo sapiens	121-126
15296492-7	2004	Introduction of a CD3 gamma chain with a disrupted di-leucine-based endocytosis motif partially restored TCR expression in cells with truncated zeta chains, indicating that the zeta chain masks the endocytosis motif in CD3 gamma and thereby stabilizes TCR cell surface expression.	di-leucine	51-61	CD3 gamma subunit of T-cell receptor complex	Homo sapiens	18-27
15296492-7	2004	Introduction of a CD3 gamma chain with a disrupted di-leucine-based endocytosis motif partially restored TCR expression in cells with truncated zeta chains, indicating that the zeta chain masks the endocytosis motif in CD3 gamma and thereby stabilizes TCR cell surface expression.	di-leucine	51-61	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	105-108
15296492-7	2004	Introduction of a CD3 gamma chain with a disrupted di-leucine-based endocytosis motif partially restored TCR expression in cells with truncated zeta chains, indicating that the zeta chain masks the endocytosis motif in CD3 gamma and thereby stabilizes TCR cell surface expression.	di-leucine	51-61	CD3 gamma subunit of T-cell receptor complex	Homo sapiens	219-228
15296492-7	2004	Introduction of a CD3 gamma chain with a disrupted di-leucine-based endocytosis motif partially restored TCR expression in cells with truncated zeta chains, indicating that the zeta chain masks the endocytosis motif in CD3 gamma and thereby stabilizes TCR cell surface expression.	di-leucine	51-61	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	252-255
13679604-7	2003	In contrast the di-leucine motif was required for both Nef-mediated and phorbol ester-induced CD4 down-modulation, suggesting that the essential requirement for the di-leucine motif in CD4 down-modulation reflects the fact that this motif is needed for the interactions of CD4 with the endocytic machinery, not for the interaction with Nef.	di-leucine	16-26	S100 calcium binding protein B	Homo sapiens	55-58
13679604-7	2003	In contrast the di-leucine motif was required for both Nef-mediated and phorbol ester-induced CD4 down-modulation, suggesting that the essential requirement for the di-leucine motif in CD4 down-modulation reflects the fact that this motif is needed for the interactions of CD4 with the endocytic machinery, not for the interaction with Nef.	di-leucine	16-26	CD4 molecule	Homo sapiens	94-97
13679604-7	2003	In contrast the di-leucine motif was required for both Nef-mediated and phorbol ester-induced CD4 down-modulation, suggesting that the essential requirement for the di-leucine motif in CD4 down-modulation reflects the fact that this motif is needed for the interactions of CD4 with the endocytic machinery, not for the interaction with Nef.	di-leucine	16-26	CD4 molecule	Homo sapiens	185-188
13679604-7	2003	In contrast the di-leucine motif was required for both Nef-mediated and phorbol ester-induced CD4 down-modulation, suggesting that the essential requirement for the di-leucine motif in CD4 down-modulation reflects the fact that this motif is needed for the interactions of CD4 with the endocytic machinery, not for the interaction with Nef.	di-leucine	16-26	CD4 molecule	Homo sapiens	185-188
13679604-7	2003	In contrast the di-leucine motif was required for both Nef-mediated and phorbol ester-induced CD4 down-modulation, suggesting that the essential requirement for the di-leucine motif in CD4 down-modulation reflects the fact that this motif is needed for the interactions of CD4 with the endocytic machinery, not for the interaction with Nef.	di-leucine	16-26	S100 calcium binding protein B	Homo sapiens	336-339
13679604-7	2003	In contrast the di-leucine motif was required for both Nef-mediated and phorbol ester-induced CD4 down-modulation, suggesting that the essential requirement for the di-leucine motif in CD4 down-modulation reflects the fact that this motif is needed for the interactions of CD4 with the endocytic machinery, not for the interaction with Nef.	di-leucine	165-175	S100 calcium binding protein B	Homo sapiens	55-58
13679604-7	2003	In contrast the di-leucine motif was required for both Nef-mediated and phorbol ester-induced CD4 down-modulation, suggesting that the essential requirement for the di-leucine motif in CD4 down-modulation reflects the fact that this motif is needed for the interactions of CD4 with the endocytic machinery, not for the interaction with Nef.	di-leucine	165-175	CD4 molecule	Homo sapiens	94-97
13679604-7	2003	In contrast the di-leucine motif was required for both Nef-mediated and phorbol ester-induced CD4 down-modulation, suggesting that the essential requirement for the di-leucine motif in CD4 down-modulation reflects the fact that this motif is needed for the interactions of CD4 with the endocytic machinery, not for the interaction with Nef.	di-leucine	165-175	CD4 molecule	Homo sapiens	185-188
13679604-7	2003	In contrast the di-leucine motif was required for both Nef-mediated and phorbol ester-induced CD4 down-modulation, suggesting that the essential requirement for the di-leucine motif in CD4 down-modulation reflects the fact that this motif is needed for the interactions of CD4 with the endocytic machinery, not for the interaction with Nef.	di-leucine	165-175	CD4 molecule	Homo sapiens	185-188
13679604-7	2003	In contrast the di-leucine motif was required for both Nef-mediated and phorbol ester-induced CD4 down-modulation, suggesting that the essential requirement for the di-leucine motif in CD4 down-modulation reflects the fact that this motif is needed for the interactions of CD4 with the endocytic machinery, not for the interaction with Nef.	di-leucine	165-175	S100 calcium binding protein B	Homo sapiens	336-339
13679604-0	2003	The di-leucine motif in the cytoplasmic tail of CD4 is not required for binding to human immunodeficiency virus type 1 Nef, but is critical for CD4 down-modulation.	di-leucine	4-14	CD4 molecule	Homo sapiens	144-147
13679604-4	2003	A di-leucine motif in the cytoplasmic tail of CD4 (residues 413/414) was reported to be essential both for Nef mediated down-modulation and for Nef binding.	di-leucine	2-12	CD4 molecule	Homo sapiens	46-49
13679604-4	2003	A di-leucine motif in the cytoplasmic tail of CD4 (residues 413/414) was reported to be essential both for Nef mediated down-modulation and for Nef binding.	di-leucine	2-12	S100 calcium binding protein B	Homo sapiens	107-110
13679604-4	2003	A di-leucine motif in the cytoplasmic tail of CD4 (residues 413/414) was reported to be essential both for Nef mediated down-modulation and for Nef binding.	di-leucine	2-12	S100 calcium binding protein B	Homo sapiens	144-147
13679604-5	2003	In order to further characterize the involvement of this di-leucine motif in CD4 down-modulation we generated a CD4 mutant in which the leucines were substituted by alanines, termed CD4(LL-AA).	di-leucine	57-67	CD4 molecule	Homo sapiens	77-80
12358769-7	2002	In addition, yeast two hybrid experiments indicated that the C-terminal tail of VAChT interacts with the micro subunit of AP-2 in a di-leucine (L485A/L486A) dependent fashion.	di-leucine	132-142	solute carrier family 18 (vesicular monoamine), member 3	Mus musculus	80-85
12713660-5	2003	Mutation of the myristoylation site or of a di-leucine motif of Nef involved in the interaction with the clathrin adaptor complexes AP1 and AP2 abolished the inhibition of retrograde transport.	di-leucine	44-54	S100 calcium binding protein B	Homo sapiens	64-67
12713660-5	2003	Mutation of the myristoylation site or of a di-leucine motif of Nef involved in the interaction with the clathrin adaptor complexes AP1 and AP2 abolished the inhibition of retrograde transport.	di-leucine	44-54	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-135
12713660-5	2003	Mutation of the myristoylation site or of a di-leucine motif of Nef involved in the interaction with the clathrin adaptor complexes AP1 and AP2 abolished the inhibition of retrograde transport.	di-leucine	44-54	transcription factor AP-2 alpha	Homo sapiens	140-143
12358769-8	2002	These observations suggest that the di-leucine motif regulates sorting of VAChT from the soma plasma membrane through a clathrin dependent mechanism prior to the targeting of the transporter to varicosities.	di-leucine	36-46	solute carrier family 18 (vesicular monoamine), member 3	Mus musculus	74-79
12221136-2	2002	Previous studies have shown that both tyrosine-based and di-leucine motifs within the LRP cytoplasmic tail are responsible for mediating its rapid endocytosis.	di-leucine	57-67	LDL receptor related protein 1	Homo sapiens	86-89
12083782-0	2002	Ile (476), a constituent of di-leucine-based motif of a major lysosomal membrane protein, LGP85/LIMP II, is important for its proper distribution in late endosomes and lysosomes.	di-leucine	28-38	scavenger receptor class B member 2	Homo sapiens	90-95
12083782-0	2002	Ile (476), a constituent of di-leucine-based motif of a major lysosomal membrane protein, LGP85/LIMP II, is important for its proper distribution in late endosomes and lysosomes.	di-leucine	28-38	scavenger receptor class B member 2	Homo sapiens	96-103
10484781-9	1999	Mutation of the di-leucine, L1487 L1488, prevented uptake of anti-myc antibodies in both basal and elevated copper conditions, thereby identifying this sequence as an endocytic signal for MNK.	di-leucine	16-26	ATPase copper transporting alpha	Homo sapiens	188-191
11598115-3	2001	We investigate the role of the di-leucine motif of vesicle-associated membrane protein 4 (VAMP4) in adaptor binding and localization of VAMP4.	di-leucine	31-41	vesicle associated membrane protein 4	Homo sapiens	51-88
11598115-3	2001	We investigate the role of the di-leucine motif of vesicle-associated membrane protein 4 (VAMP4) in adaptor binding and localization of VAMP4.	di-leucine	31-41	vesicle associated membrane protein 4	Homo sapiens	90-95
11598115-3	2001	We investigate the role of the di-leucine motif of vesicle-associated membrane protein 4 (VAMP4) in adaptor binding and localization of VAMP4.	di-leucine	31-41	vesicle associated membrane protein 4	Homo sapiens	136-141
11832379-6	2002	Di-leucine motifs are present in NH(2) and COOH termini at positions similar to the GLUT-4 FQQI and LL targeting motifs.	di-leucine	0-10	solute carrier family 2 member 4	Homo sapiens	84-90
11859093-0	2002	Cutting Edge: Internalization of transduced E-selectin by cultured human endothelial cells: comparison of dermal microvascular and umbilical vein cells and identification of a phosphoserine-type di-leucine motif.	di-leucine	195-205	selectin E	Homo sapiens	44-54
10747918-6	2000	We also found that the distal di-leucine motif within the LRP tail contributes to its endocytosis, and its function is independent of the YXXL motif.	di-leucine	30-40	LDL receptor related protein 1	Homo sapiens	58-61
10564285-0	1999	Di-leucine signals mediate targeting of tyrosinase and synaptotagmin to synaptic-like microvesicles within PC12 cells.	di-leucine	0-10	tyrosinase	Homo sapiens	40-50
10564285-4	1999	We have found that a di-leucine signal within the cytoplasmic tail of human tyrosinase is responsible for the majority of the targeting of HRP-tyrosinase chimeras to SLMV in PC12 cells.	di-leucine	21-31	tyrosinase	Homo sapiens	76-86
10564285-4	1999	We have found that a di-leucine signal within the cytoplasmic tail of human tyrosinase is responsible for the majority of the targeting of HRP-tyrosinase chimeras to SLMV in PC12 cells.	di-leucine	21-31	tyrosinase	Homo sapiens	143-153
10544254-0	1999	Role of the carboxyl-terminal region, di-leucine motif and cysteine residues in signalling and internalization of vasopressin V1a receptor.	di-leucine	38-48	arginine vasopressin receptor 1A	Homo sapiens	114-138
10377252-0	1999	The N-terminal segment of endothelin-converting enzyme (ECE)-1b contains a di-leucine motif that can redirect neprilysin to an intracellular compartment in Madin-Darby canine kidney (MDCK) cells.	di-leucine	75-85	membrane metalloendopeptidase	Canis lupus familiaris	110-120
10212263-6	1999	However, the properties of this di-leucine-based signal were distinguished from that of CD3gamma by overexpression studies; overexpression of the tyrosinase signal, but not the well characterized CD3gamma signal, induced a 4-fold enlargement of late endosomes and lysosomes and interfered with endosomal sorting mediated by both tyrosine- and other di-leucine-based signals.	di-leucine	32-42	tyrosinase	Homo sapiens	146-156
10318764-7	1999	We observed that a di-leucine motif (L1487L1488) was essential for rapid internalisation of chimeric CD8 proteins and the full-length Menkes cDNA from the plasma membrane.	di-leucine	19-29	CD8a molecule	Homo sapiens	101-104
10212263-6	1999	However, the properties of this di-leucine-based signal were distinguished from that of CD3gamma by overexpression studies; overexpression of the tyrosinase signal, but not the well characterized CD3gamma signal, induced a 4-fold enlargement of late endosomes and lysosomes and interfered with endosomal sorting mediated by both tyrosine- and other di-leucine-based signals.	di-leucine	349-359	tyrosinase	Homo sapiens	146-156
9722605-0	1998	Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE.	di-leucine	7-17	SNAP receptor VAM3	Saccharomyces cerevisiae S288C	114-119
10085147-8	1999	Furthermore, the di-leucine motif in the cytosolic domain of FcRn was required for rapid and efficient endocytosis but not for basolateral sorting of the chimera.	di-leucine	17-27	Fc gamma receptor and transporter	Rattus norvegicus	61-65
9841903-0	1999	The tyrosinase tail mediates sorting to the lysosomal compartment in MDCK cells via a di-leucine and a tyrosine-based signal.	di-leucine	86-96	tyrosinase	Canis lupus familiaris	4-14
9817923-6	1998	In vitro mutagenesis of the human MNK cDNA and immunofluorescence detection of mutant forms of MNK expressed in cultured cells demonstrated that the di-leucine, L1487L1488, was essential for localization of MNK within the TGN, but not for copper efflux.	di-leucine	149-159	ATPase copper transporting alpha	Homo sapiens	34-37
9817923-6	1998	In vitro mutagenesis of the human MNK cDNA and immunofluorescence detection of mutant forms of MNK expressed in cultured cells demonstrated that the di-leucine, L1487L1488, was essential for localization of MNK within the TGN, but not for copper efflux.	di-leucine	149-159	ATPase copper transporting alpha	Homo sapiens	95-98
9817923-6	1998	In vitro mutagenesis of the human MNK cDNA and immunofluorescence detection of mutant forms of MNK expressed in cultured cells demonstrated that the di-leucine, L1487L1488, was essential for localization of MNK within the TGN, but not for copper efflux.	di-leucine	149-159	ATPase copper transporting alpha	Homo sapiens	95-98
9817923-7	1998	We suggest that this di-leucine motif is a putative endocytic targeting motif necessary for the retrieval of MNK from the plasma membrane to the TGN.	di-leucine	21-31	ATPase copper transporting alpha	Homo sapiens	109-112
9651318-6	1998	The closely related vesicular acetylcholine transporter (VAChT) contains a similar di-leucine sequence within the cytoplasmic COOH-terminal domain that when mutated results in accumulation of VAChT at the plasma membrane.	di-leucine	83-93	solute carrier family 18 member A3	Homo sapiens	20-55
9651318-6	1998	The closely related vesicular acetylcholine transporter (VAChT) contains a similar di-leucine sequence within the cytoplasmic COOH-terminal domain that when mutated results in accumulation of VAChT at the plasma membrane.	di-leucine	83-93	solute carrier family 18 member A3	Homo sapiens	57-62
9651318-6	1998	The closely related vesicular acetylcholine transporter (VAChT) contains a similar di-leucine sequence within the cytoplasmic COOH-terminal domain that when mutated results in accumulation of VAChT at the plasma membrane.	di-leucine	83-93	solute carrier family 18 member A3	Homo sapiens	192-197
9651318-7	1998	The VAChT di-leucine sequence also confers internalization when appended to two other proteins and in one of these chimeras, conversion of the di-leucine sequence to di-alanine reduces the internalization rate by 50%.	di-leucine	10-20	solute carrier family 18 member A3	Homo sapiens	4-9
9651318-7	1998	The VAChT di-leucine sequence also confers internalization when appended to two other proteins and in one of these chimeras, conversion of the di-leucine sequence to di-alanine reduces the internalization rate by 50%.	di-leucine	143-153	solute carrier family 18 member A3	Homo sapiens	4-9
9632708-0	1998	Di-leucine-mediated internalization of ligand by a truncated growth hormone receptor is independent of the ubiquitin conjugation system.	di-leucine	0-10	growth hormone receptor	Homo sapiens	61-84
9632708-6	1998	Here, we present evidence that in addition to the ubiquitin-dependent endocytosis signal, the cytosolic tail of the GHR contains a di-leucine motif.	di-leucine	131-141	growth hormone receptor	Homo sapiens	116-119
9632708-7	1998	Upon truncation of the GHR at amino acid residue 349, this di-leucine motif is activated and mediates ubiquitin-independent internalization of the receptor.	di-leucine	59-69	growth hormone receptor	Homo sapiens	23-26
9632708-8	1998	Di-leucine-mediated GHR internalization requires functional clathrin-coated pits and results in GHR transport to the lysosome.	di-leucine	0-10	growth hormone receptor	Homo sapiens	20-23
9632708-8	1998	Di-leucine-mediated GHR internalization requires functional clathrin-coated pits and results in GHR transport to the lysosome.	di-leucine	0-10	growth hormone receptor	Homo sapiens	96-99
8931560-2	1996	The epidermal growth factor receptor (EGFR) contains two di-leucine residues at 658 (TLRRLLQER) and 679 (NQALLRIL).	di-leucine	57-67	epidermal growth factor receptor	Cricetulus griseus	4-36
9179853-0	1997	A C-terminal di-leucine motif and nearby sequences are required for NH4(+)-induced inactivation and degradation of the general amino acid permease, Gap1p, of Saccharomyces cerevisiae.	di-leucine	13-23	amino acid permease GAP1	Saccharomyces cerevisiae S288C	148-153
9300530-4	1997	We found that serine126 and the di-leucine motif (Leu131-Leu132) are required for phorbol-ester-induced TCR downregulation, but they are not necessary for enterotoxin superantigen or antibody-induced TCR downregulation.	di-leucine	32-42	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	104-107
8931560-2	1996	The epidermal growth factor receptor (EGFR) contains two di-leucine residues at 658 (TLRRLLQER) and 679 (NQALLRIL).	di-leucine	57-67	epidermal growth factor receptor	Cricetulus griseus	38-42
27337370-4	2016	A single di-leucine endocytic motif within the cytosolic carboxy tail of ATP7A (1487LL) was previously shown to be essential for TGN localization by functioning in retrieval from the plasma membrane, however, the requirement of other di-leucine signals in this region has not been fully investigated.	di-leucine	9-19	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	73-78
8871625-1	1996	Expression of the HIV Nef protein results in the down-regulation of cell surface expression of CD4, with a di-leucine motif in the cytoplasmic domain of CD4 being required for this effect.	di-leucine	107-117	S100 calcium binding protein B	Homo sapiens	22-25
8871625-1	1996	Expression of the HIV Nef protein results in the down-regulation of cell surface expression of CD4, with a di-leucine motif in the cytoplasmic domain of CD4 being required for this effect.	di-leucine	107-117	CD4 molecule	Homo sapiens	95-98
8871625-1	1996	Expression of the HIV Nef protein results in the down-regulation of cell surface expression of CD4, with a di-leucine motif in the cytoplasmic domain of CD4 being required for this effect.	di-leucine	107-117	CD4 molecule	Homo sapiens	153-156
8626701-2	1996	We have recently shown that both phosphorylation of Ser-126 and the presence of the di-leucine sequence Leu-131 and Leu-132 in CD3 gamma are required for protein kinase C (PKC)-mediated TCR down-regulation.	di-leucine	84-94	CD3 gamma subunit of T-cell receptor complex	Homo sapiens	127-136
8626701-2	1996	We have recently shown that both phosphorylation of Ser-126 and the presence of the di-leucine sequence Leu-131 and Leu-132 in CD3 gamma are required for protein kinase C (PKC)-mediated TCR down-regulation.	di-leucine	84-94	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	186-189
8187769-0	1994	CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor.	di-leucine	45-55	CD3 gamma subunit of T-cell receptor complex	Homo sapiens	0-9
8187769-6	1994	Point mutation analyses confirmed this observation and demonstrated that a membrane-proximal di-leucine motif (L131 and L132) in the cytoplasmic tail of CD3 gamma was required for PKC-mediated TCR down-regulation in addition to phosphorylation at S126.	di-leucine	93-103	CD3 gamma subunit of T-cell receptor complex	Homo sapiens	153-162
8621406-0	1996	A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor.	di-leucine	2-12	interleukin 6	Homo sapiens	49-62
8621406-0	1996	A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor.	di-leucine	2-12	interleukin 6	Homo sapiens	64-68
8621406-0	1996	A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor.	di-leucine	2-12	interleukin 6 cytokine family signal transducer	Homo sapiens	88-93
8621406-0	1996	A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor.	di-leucine	2-12	interleukin 6	Homo sapiens	156-160
29123098-5	2017	Importantly, we show that a characteristic di-leucine motif (SVRPLL) in the C-terminal cytoplasmic region of ATP11C becomes functional upon PKC activation.	di-leucine	43-53	ATPase phospholipid transporting 11C	Homo sapiens	109-115
27337370-7	2016	Using the stabilized mouse Atp7a construct, we identify a second di-leucine motif in the carboxy tail of ATP7A (1459LL) as essential for steady-state localization in the TGN by functioning in endosome-to-TGN trafficking.	di-leucine	65-75	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	27-32
27337370-7	2016	Using the stabilized mouse Atp7a construct, we identify a second di-leucine motif in the carboxy tail of ATP7A (1459LL) as essential for steady-state localization in the TGN by functioning in endosome-to-TGN trafficking.	di-leucine	65-75	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	105-110
27337370-8	2016	Taken together, these findings demonstrate that multiple di-leucine signals are required for recycling ATP7A from the plasma membrane to the TGN and illustrate the utility of large-scale codon reassignment as a simple and effective approach to circumvent cDNA instability in high-copy plasmids.	di-leucine	57-67	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	103-108
25574028-6	2015	We show that adaptor protein (AP) complexes 1 and 2 physically interact with ATP7A and that binding is mediated in part by a carboxyl-terminal di-leucine motif.	di-leucine	143-153	ATPase copper transporting alpha	Homo sapiens	77-82
25619824-9	2015	Mutational analysis of AtBOR1 revealed that the acidic di-leucine motif is required for the polarity and high-B-induced vacuolar sorting of AtBOR1.	di-leucine	55-65	HCO3- transporter family	Arabidopsis thaliana	23-29
25619824-9	2015	Mutational analysis of AtBOR1 revealed that the acidic di-leucine motif is required for the polarity and high-B-induced vacuolar sorting of AtBOR1.	di-leucine	55-65	HCO3- transporter family	Arabidopsis thaliana	140-146
25637025-5	2015	The plakin family member periplakin, identified in yeast two-hybrid assays, interacted with a membrane-proximal di-leucine motif, located proximal to the B30.2 domain in the BTN3A1 cytoplasmic tail.	di-leucine	112-122	butyrophilin subfamily 3 member A1	Homo sapiens	174-180