PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15539792-3	2004	METHODS: In this study we have demonstrated that the mechanism of oxalate-induced peroxidative injury is through the induction of TGF-beta1 and glutathione (GSH) redox imbalance in LLC-PK1 cells.	Oxalates	66-73	transforming growth factor beta 1	Sus scrofa	130-139
15539792-4	2004	RESULTS: LLC-PK1, renal epithelial cells exposed to oxalate had significantly higher reactive oxygen species (ROS) production; higher TGF-beta1 levels, as measured by ELISA (1.89 +/- 0.035 fold increase) or Western blot (1.65 +/- 0.01 fold increase); increased malondialdehyde formation; increased LDH release, and loss of cell viability.	Oxalates	52-59	transforming growth factor beta 1	Sus scrofa	134-143
15539792-5	2004	In addition, oxalate exposure significantly decreased GSH content, glutathione reductase, glucose-6-phosphate dehydrogenase activities, and increased oxidized GSH content.	Oxalates	13-20	glutathione-disulfide reductase	Sus scrofa	67-88
15539792-5	2004	In addition, oxalate exposure significantly decreased GSH content, glutathione reductase, glucose-6-phosphate dehydrogenase activities, and increased oxidized GSH content.	Oxalates	13-20	glucose-6-phosphate dehydrogenase	Sus scrofa	90-123
15539792-7	2004	Vitamin E, catalase, or desferoxamine treatment also significantly restored the oxalate-induced cellular GSH redox status toward the control level, and vitamin E treatment significantly attenuated the oxalate-mediated increase in TGF-beta1 protein in cultured LLC-PK1 cells.	Oxalates	80-87	catalase	Sus scrofa	11-19
15539792-7	2004	Vitamin E, catalase, or desferoxamine treatment also significantly restored the oxalate-induced cellular GSH redox status toward the control level, and vitamin E treatment significantly attenuated the oxalate-mediated increase in TGF-beta1 protein in cultured LLC-PK1 cells.	Oxalates	80-87	transforming growth factor beta 1	Sus scrofa	230-239
15539792-7	2004	Vitamin E, catalase, or desferoxamine treatment also significantly restored the oxalate-induced cellular GSH redox status toward the control level, and vitamin E treatment significantly attenuated the oxalate-mediated increase in TGF-beta1 protein in cultured LLC-PK1 cells.	Oxalates	201-208	transforming growth factor beta 1	Sus scrofa	230-239
15539792-8	2004	CONCLUSIONS: This is the first study to demonstrate that the mechanism of oxalate-induced free radical production in renal tubular epithelial cells is through the activation of NAD(P)H oxidase via cytokine TGF-beta1 induction.	Oxalates	74-81	transforming growth factor beta 1	Sus scrofa	206-215
15313148-14	2004	CONCLUSION: Increased expression of p62 may be due to membrane damage induced by oxalate stress, and may be used as a diagnostic marker.	Oxalates	81-88	nucleoporin 62	Homo sapiens	36-39
15327412-8	2004	Excessive intake of calcium and oxalate, precursors of the most common type of human renal stones, dramatically increases both the frequency and the severity of renal calcium crystal formation in THP-deficient, but not in wild-type mice.	Oxalates	32-39	uromodulin	Homo sapiens	196-199
15327412-9	2004	Under high calcium/oxalate conditions, the absence of THP triggers a marked, adaptive induction in renal epithelial cells of osteopontin (OPN), a potent inhibitor of bone mineralization and vascular calcification.	Oxalates	19-26	uromodulin	Mus musculus	54-57
15464418-3	2004	When AGT is absent, glyoxylate is converted to oxalate which forms insoluble calcium salts that accumulate in the kidney and other organs.	Oxalates	47-54	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	5-8
15070814-1	2004	The sat-1 transporter mediates sulfate/bicarbonate/oxalate anion exchange in vivo at the basolateral membrane of the kidney proximal tubule.	Oxalates	51-58	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	4-9
15253722-9	2004	CONCLUSION: These data suggest that the use of lipase inhibitors, especially under a diet rich in oxalate alone or associated with fat, leads to a significant and marked increase in urinary oxalate and a slight reduction in uCa and uMg that, taken together, resulted in an increase in AP (CaOx) index(rat), elevating the risk of stone formation.	Oxalates	98-105	lipase G, endothelial type	Rattus norvegicus	47-53
15253722-9	2004	CONCLUSION: These data suggest that the use of lipase inhibitors, especially under a diet rich in oxalate alone or associated with fat, leads to a significant and marked increase in urinary oxalate and a slight reduction in uCa and uMg that, taken together, resulted in an increase in AP (CaOx) index(rat), elevating the risk of stone formation.	Oxalates	190-197	lipase G, endothelial type	Rattus norvegicus	47-53
14977559-7	2004	Renal epithelial cells on exposure to oxalate and CaOx crystals produce some of the inflammatory molecules such as monocyte chemoattractant protein-1 (MCP-1) with no apparent role in crystal formation.	Oxalates	38-45	C-C motif chemokine ligand 2	Homo sapiens	115-149
15220318-4	2004	The reduction in maximal Ca(2+)-dependent ATPase activity at 30 min of exercise was accompanied by oxalate-dependent reductions (P < 0.05) in Ca(2+) uptake by approximately 20% (370 +/- 22 vs. 298 +/- 25 micromol x g protein(-1) x min(-1)).	Oxalates	99-106	GTP binding protein 1	Homo sapiens	218-230
15123433-0	2004	The oxalate effect on release of iron from human serum transferrin explained.	Oxalates	4-11	transferrin	Homo sapiens	55-66
14977559-7	2004	Renal epithelial cells on exposure to oxalate and CaOx crystals produce some of the inflammatory molecules such as monocyte chemoattractant protein-1 (MCP-1) with no apparent role in crystal formation.	Oxalates	38-45	C-C motif chemokine ligand 2	Homo sapiens	151-156
14978165-14	2004	These results show for the first time that oxalate can activate the renal renin-angiotensin system and that oxalate-induced upregulation of OPN is in part mediated via renal renin-angiotensin system.	Oxalates	43-50	renin	Rattus norvegicus	74-79
15063614-1	2004	Oxalate oxidase catalyses the degradation of oxalic acid to carbon dioxide and hydrogen peroxide and is of commercial importance for clinical analyses of oxalate in biological samples.	Oxalates	154-161	germin-like protein 8-4	Triticum aestivum	0-15
14978165-14	2004	These results show for the first time that oxalate can activate the renal renin-angiotensin system and that oxalate-induced upregulation of OPN is in part mediated via renal renin-angiotensin system.	Oxalates	108-115	secreted phosphoprotein 1	Rattus norvegicus	140-143
14978165-14	2004	These results show for the first time that oxalate can activate the renal renin-angiotensin system and that oxalate-induced upregulation of OPN is in part mediated via renal renin-angiotensin system.	Oxalates	108-115	renin	Rattus norvegicus	174-179
15203903-1	2004	Mouse PAT1 (putative anion transporter, CEFX, slc26a6), an orthologue of human SLC26A6, was recently identified at the intestinal brush-border membrane and shown to transport organic anions such as formate and oxalate, as well as inorganic ions.	Oxalates	210-217	solute carrier family 36 member 1	Homo sapiens	6-10
15203903-1	2004	Mouse PAT1 (putative anion transporter, CEFX, slc26a6), an orthologue of human SLC26A6, was recently identified at the intestinal brush-border membrane and shown to transport organic anions such as formate and oxalate, as well as inorganic ions.	Oxalates	210-217	solute carrier family 26 member 6	Homo sapiens	46-53
15203903-1	2004	Mouse PAT1 (putative anion transporter, CEFX, slc26a6), an orthologue of human SLC26A6, was recently identified at the intestinal brush-border membrane and shown to transport organic anions such as formate and oxalate, as well as inorganic ions.	Oxalates	210-217	solute carrier family 26 member 6	Homo sapiens	79-86
14729300-1	2004	A series of new iron(III) and copper(II) complexes of bovine serum transferrin (BTf), with carbonate and/or oxalate as the synergistic anion, are presented.	Oxalates	108-115	transferrin	Homo sapiens	67-78
14729300-6	2004	None of the other members of the transferrin family of proteins has ever been demonstrated to bind the ferric and cupric ions one after the other, each occupying a separate specific-binding site of the same transferrin molecule, as a response to the coordination restrictions imposed by the oxalate ion.	Oxalates	291-298	transferrin	Homo sapiens	33-44
14729300-6	2004	None of the other members of the transferrin family of proteins has ever been demonstrated to bind the ferric and cupric ions one after the other, each occupying a separate specific-binding site of the same transferrin molecule, as a response to the coordination restrictions imposed by the oxalate ion.	Oxalates	291-298	transferrin	Homo sapiens	207-218
12759755-7	2004	The functional versatility of SLC26A6 identifies it as the primary candidate for the apical Cl(-)-formate/oxalate and Cl(-)-base exchanger of brush border membranes in the renal proximal tubule, with a central role in the reabsorption of Na(+)-Cl(-) from the glomerular ultrafiltrate.	Oxalates	106-113	solute carrier family 26, member 6	Mus musculus	30-37
14766409-3	2004	Particular attention is paid to evidence linking oxalate-induced activation of cytosolic phospholipase A2 to changes in gene expression and to the activation of a second signaling pathway involving ceramide.	Oxalates	49-56	phospholipase A2 group IVA	Homo sapiens	79-105
15292681-11	2004	The increase in p62 protein expression may be either due to increased expression of certain genes or degradation of the cell membrane by oxalate-induced cell injury.	Oxalates	137-144	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	16-19
15292681-12	2004	Thus, the present study suggests that the increased expression of this protein (p62) may be due to the oxalate induction.	Oxalates	103-110	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	80-83
12856168-5	2003	In the nucleus, histone H(1B) (27.5 kDa), nuclear membrane protein (68 kDa) and nuclear pore complex protein (205 kDa) were present with oxalate binding activities.	Oxalates	137-144	H1.5 linker histone, cluster member	Homo sapiens	16-28
14635115-1	2003	Primary hyperoxaluria type 2, an inherited autosomal recessive disorder of endogenous oxalate overproduction, is caused by mutations in the GRHPR gene encoding the glyoxylate/hydroxypyruvate reductase enzyme.	Oxalates	86-93	glyoxylate and hydroxypyruvate reductase	Homo sapiens	140-145
15499208-3	2004	Elevated levels of oxalate and calcium oxalate crystals, however, provoke renal cells to increase the synthesis of osteopontin, bikunin, heparan sulfate proteoglycan, monocyte chemoattractant protein-1, and prostaglandin E(2), which are known mediators of the inflammatory processes and extracellular matrix production.	Oxalates	19-26	secreted phosphoprotein 1	Rattus norvegicus	115-126
15499208-3	2004	Elevated levels of oxalate and calcium oxalate crystals, however, provoke renal cells to increase the synthesis of osteopontin, bikunin, heparan sulfate proteoglycan, monocyte chemoattractant protein-1, and prostaglandin E(2), which are known mediators of the inflammatory processes and extracellular matrix production.	Oxalates	19-26	C-C motif chemokine ligand 2	Rattus norvegicus	167-201
15499208-8	2004	Both oxalate and calcium oxalate crystals selectively activate p38 mitogen-activated protein kinase in the exposed tubular cells.	Oxalates	5-12	mitogen activated protein kinase 14	Rattus norvegicus	63-66
15033694-4	2003	Studies from our laboratory demonstrated that exposure of renal epithelial cells to oxalate and COM-crystals resulted in activation of the p38 MAP kinase pathway.	Oxalates	84-91	mitogen-activated protein kinase 14	Homo sapiens	139-142
15033694-5	2003	Moreover, the inhibition of the p38 MAO kinase pathway resulted in the inhibition of oxalate as well as COM-crystal-induced reinitiation of the DNA synthesis.	Oxalates	85-92	mitogen-activated protein kinase 14	Homo sapiens	32-35
14574528-0	2003	Angiotensin II involvement in adaptive enteric oxalate excretion in rats with chronic renal failure induced by hyperoxaluria.	Oxalates	47-54	angiotensinogen	Rattus norvegicus	0-14
14574528-10	2003	CONCLUSION: Although enteric oxalate secretion can be correlated with elevations in plasma oxalate in the absence of overt renal insufficiency by an ANG II-independent mechanism, the present results suggest that some degree of renal insufficiency is necessary to induce ANG II-mediated colonic oxalate secretion.	Oxalates	29-36	angiogenin	Rattus norvegicus	149-152
14574528-10	2003	CONCLUSION: Although enteric oxalate secretion can be correlated with elevations in plasma oxalate in the absence of overt renal insufficiency by an ANG II-independent mechanism, the present results suggest that some degree of renal insufficiency is necessary to induce ANG II-mediated colonic oxalate secretion.	Oxalates	29-36	angiotensinogen	Rattus norvegicus	149-155
12907408-2	2003	Oxalates were extracted in water by refluxing for 2 h. The method is based on the oxidation of oxalate by the oxidase and the determination of the resulting hydrogen peroxide, which in presence of peroxidase, 3-methyl-2 benzotiazinolone and 3-dimethylamino benzoic, gives an indamine compound with an absorption maximum at 590 nm.	Oxalates	0-8	peroxidase 3	Cicer arietinum	197-207
12829001-6	2003	This method proved to be useful when used for differential diagnosis of PH1 and for monitoring the plasma levels of glycolate and oxalate in two PH1 patients before and after dialysis and liver transplantation.	Oxalates	130-137	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	145-148
12660328-7	2003	Oxalate formation from L-hydroxyproline but not that from glycolate was significantly reduced when mitochondrial SPT/AGT had been induced by glucagon.	Oxalates	0-7	angiotensinogen	Rattus norvegicus	117-120
12540840-10	2003	Using HEK293 cells to express human SERCA3a, we were able to measure both ATP-mediated, oxalate-dependent (45)Ca(2+) uptake and Ca(2+)-dependent ATP hydrolysis activities due exclusively to SERCA3.	Oxalates	88-95	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	36-42
12624657-11	2003	The deglycosylated THP decreased the effect of the protection of the MDCK cells from oxalate-induced injury and an increase of adhesion of the COM crystals to the MDCK cells.	Oxalates	85-92	uromodulin	Canis lupus familiaris	19-22
12646708-2	2003	nFbp was reconstituted as a stable iron containing protein by using a number of different exogenous anions [arsenate, citrate, nitrilotriacetate, pyrophosphate, and oxalate (symbolized by X)] in addition to phosphate, predominantly present in the recombinant form of the protein.	Oxalates	165-172	programmed cell death 11	Homo sapiens	0-4
12820359-5	2003	We measured Tumor M2-PK in each of these groups in different specimens of EDTA-plasma, serum, heparin-, citrate-, fluoride- and oxalate-plasma.	Oxalates	128-135	pyruvate kinase M1/2	Homo sapiens	12-23
12624657-12	2003	Therefore, the effects of THP on the protection of oxalate induced radical injury may be partly due to its intact glycosylation and its adhesion to the cell membrane.	Oxalates	51-58	uromodulin	Canis lupus familiaris	26-29
12605306-4	2003	The sulfate anion transporter 1 (sat-1) cloned from human, rat and mouse, transported oxalate and sulfate.	Oxalates	86-93	solute carrier family 26 member 1	Homo sapiens	4-31
12605306-4	2003	The sulfate anion transporter 1 (sat-1) cloned from human, rat and mouse, transported oxalate and sulfate.	Oxalates	86-93	solute carrier family 26 member 1	Homo sapiens	33-38
12217875-5	2002	Whereas Slc26a6 is capable of Cl(-), SO, formate, and oxalate uptake when expressed in Xenopus laevis oocytes, Slc26a1 transports only SO and oxalate.	Oxalates	54-61	anion exchanger SLC26A6	Xenopus laevis	8-15
12624656-2	2003	In the present study, we tested whether the antioxidants vitamin E, superoxide dismutase (SOD), catalase and desferoxamine (DFO) can provide protection against oxalate toxicity in LLC-PK(1) cells.	Oxalates	160-167	superoxide dismutase 1	Homo sapiens	68-88
12624656-2	2003	In the present study, we tested whether the antioxidants vitamin E, superoxide dismutase (SOD), catalase and desferoxamine (DFO) can provide protection against oxalate toxicity in LLC-PK(1) cells.	Oxalates	160-167	superoxide dismutase 1	Homo sapiens	90-93
12624656-5	2003	The effect of vitamin E (200 microM), DFO (1.0 mM), SOD (400 U), and catalase (400 U) on oxalate-exposed cells was tested.	Oxalates	89-96	catalase	Homo sapiens	69-77
12624656-7	2003	Cellular glutathione peroxidase and catalase activities were decreased on exposure to oxalate.	Oxalates	86-93	catalase	Homo sapiens	36-44
12624657-0	2003	Effects of Tamm-Horsfall protein on the protection of MCDK cells from oxalate induced free radical injury.	Oxalates	70-77	uromodulin	Canis lupus familiaris	11-32
12217875-5	2002	Whereas Slc26a6 is capable of Cl(-), SO, formate, and oxalate uptake when expressed in Xenopus laevis oocytes, Slc26a1 transports only SO and oxalate.	Oxalates	142-149	solute carrier family 26 (anion exchanger), member 1 L homeolog	Xenopus laevis	111-118
12217875-7	2002	Cis-inhibition and efflux experiments indicate that Slc26a6 can mediate the exchange of both Cl(-) and SOwith a number of substrates, including formate and oxalate.	Oxalates	156-163	solute carrier family 26, member 6	Mus musculus	52-59
12217875-9	2002	The data indicate that Slc26a6 encodes an apical Cl(-)/formate/oxalate and Cl(-)/base exchanger and reveal significant mechanistic differences between apical and basolateral oxalate exchangers of the proximal tubule.	Oxalates	63-70	solute carrier family 26, member 6	Mus musculus	23-30
12217875-9	2002	The data indicate that Slc26a6 encodes an apical Cl(-)/formate/oxalate and Cl(-)/base exchanger and reveal significant mechanistic differences between apical and basolateral oxalate exchangers of the proximal tubule.	Oxalates	174-181	solute carrier family 26, member 6	Mus musculus	23-30
12119287-3	2002	Influx of [(14)C]formate into Slc26a6-expressing oocytes was inhibited by sulfate, oxalate, and p-aminohippurate (PAH), indicating affinity for these anions.	Oxalates	83-90	solute carrier family 26, member 6	Mus musculus	30-37
12119287-4	2002	Measurements of uptake of [(14)C]oxalate, [(14)C]PAH, and [(35)S]sulfate indicated that Slc26a6 can mediate transport of oxalate and sulfate but not PAH.	Oxalates	33-40	solute carrier family 26, member 6	Mus musculus	88-95
12119287-5	2002	Studies of the effect of external anions on [(14)C]oxalate efflux demonstrated Slc26a6-mediated Cl(-)-oxalate, oxalate-formate, oxalate-oxalate, and oxalate-sulfate exchange.	Oxalates	51-58	solute carrier family 26, member 6	Mus musculus	79-86
12119287-5	2002	Studies of the effect of external anions on [(14)C]oxalate efflux demonstrated Slc26a6-mediated Cl(-)-oxalate, oxalate-formate, oxalate-oxalate, and oxalate-sulfate exchange.	Oxalates	102-109	solute carrier family 26, member 6	Mus musculus	79-86
12119287-9	2002	We conclude that mouse Slc26a6 has affinity for oxalate, sulfate, and HCO(3)(-) in addition to Cl(-) and formate and can function in multiple exchange modes involving pairs of these anions.	Oxalates	48-55	solute carrier family 26, member 6	Mus musculus	23-30
12187263-12	2002	CONCLUSIONS: In response to exposure to oxalate and calcium oxalate crystals renal epithelial cells increase the production of osteopontin, which may have a significant role in calcium oxalate nephrolithiasis.	Oxalates	40-47	secreted phosphoprotein 1	Rattus norvegicus	127-138
12185464-1	2002	The primary hyperoxalurias (PH1 and PH2) are rare defects of oxalate overproduction.	Oxalates	61-68	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	28-31
12185464-1	2002	The primary hyperoxalurias (PH1 and PH2) are rare defects of oxalate overproduction.	Oxalates	61-68	glyoxylate and hydroxypyruvate reductase	Homo sapiens	36-39
12185464-2	2002	There are only 24 reported cases of PH2, which is characterized by raised urine oxalate and L-glycerate.	Oxalates	80-87	glyoxylate and hydroxypyruvate reductase	Homo sapiens	36-39
11823457-0	2002	Oxalate selectively activates p38 mitogen-activated protein kinase and c-Jun N-terminal kinase signal transduction pathways in renal epithelial cells.	Oxalates	0-7	transcription factor Jun	Sus scrofa	71-76
12119287-10	2002	In the presence of high oxalate concentrations as found in renal tubular fluid and urine, Slc26a6 may largely function as an electrogenic Cl(-)-oxalate exchanger.	Oxalates	24-31	solute carrier family 26, member 6	Mus musculus	90-97
12382579-7	2002	The effects of substance P on both fibroblast proliferation and TGF-beta 1 mRNA expression could be antagonized by L-703, 606 oxalate salt.	Oxalates	126-138	tachykinin precursor 1	Homo sapiens	15-26
12382579-7	2002	The effects of substance P on both fibroblast proliferation and TGF-beta 1 mRNA expression could be antagonized by L-703, 606 oxalate salt.	Oxalates	126-138	transforming growth factor beta 1	Homo sapiens	64-74
11823457-5	2002	Oxalate exposure also induced modest activation of JNK, as monitored by phosphorylation of c-Jun.	Oxalates	0-7	transcription factor Jun	Sus scrofa	91-96
11733634-2	2001	The purpose of this study was to evaluate oxalate mass removal using various dialysis modes in a patient suffering from primary hyperoxaluria type 1 (PH1).	Oxalates	42-49	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	150-153
11862550-1	2002	Oxalate oxidase catalyzes the oxidation of oxalate to carbon dioxide and hydrogen peroxide, making it useful for clinical analysis of oxalate in biological fluids.	Oxalates	43-50	LOC548260	Hordeum vulgare	0-15
11862550-1	2002	Oxalate oxidase catalyzes the oxidation of oxalate to carbon dioxide and hydrogen peroxide, making it useful for clinical analysis of oxalate in biological fluids.	Oxalates	134-141	LOC548260	Hordeum vulgare	0-15
11786090-0	2002	Oxalate ions and calcium oxalate crystals stimulate MCP-1 expression by renal epithelial cells.	Oxalates	0-7	chemokine (C-C motif) ligand 2	Mus musculus	52-57
11733634-10	2001	To eliminate sufficient amounts of oxalate generated in PH1 patients, at least 8 h of daily dialysis with a high-flux membrane would probably be required.	Oxalates	35-42	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	56-59
11288870-6	2001	The recombination of CO2*- to give oxalate directly is estimated to have a contribution of <25%.	Oxalates	35-42	complement C2	Homo sapiens	21-24
18968358-6	2001	As for Cu(II), the interference by Co(II) was very serious, which was eliminated by oxalate ion.	Oxalates	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
11457720-7	2001	In contrast, stimulation of NaCl absorption by oxalate is preserved in NHE3 null mice, indicating that oxalate-stimulated NaCl absorption is independent of Na(+)-H(+) exchange.	Oxalates	103-110	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	71-75
11246420-1	2001	Band 3 (AE1), the anion exchanger of the human erythrocyte membrane, mediates not only fluxes of small hydrophilic anions (e.g., chloride, oxalate), but also the flip-flop of long-chain amphiphilic anions (e.g., dodecylsulfate).	Oxalates	139-146	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	8-11
11099610-1	2000	The enzyme alcohol dehydrogenase metabolizes ingested ethylene glycol (EG) to the toxic compounds glycolic and oxalic acids.	Oxalates	111-123	aldo-keto reductase family 1 member A1	Homo sapiens	11-32
10916087-8	2000	Treatment with mepacrine resulted in a 75 to 113% reduction of oxalate-induced c-jun, egr-1, and c-myc mRNA, while AACOCF3 caused a 41 to 46% reduction of oxalate-induced c-jun and egr-1 mRNA.	Oxalates	63-70	Jun proto-oncogene, AP-1 transcription factor subunit	Canis lupus familiaris	79-84
11087667-3	2000	Three human transporter proteins have been functionally characterized: SLC26A2 (DTDST), SLC26A3 (CLD or DRA), and SLC26A4 (PDS) can transport with different specificities the chloride, iodine, bicarbonate, oxalate, and hydroxyl anions, whereas SLC26A5 (prestin) was suggested to act as the motor protein of the cochlear outer hair cell.	Oxalates	206-213	solute carrier family 26 member 2	Homo sapiens	71-78
11087667-3	2000	Three human transporter proteins have been functionally characterized: SLC26A2 (DTDST), SLC26A3 (CLD or DRA), and SLC26A4 (PDS) can transport with different specificities the chloride, iodine, bicarbonate, oxalate, and hydroxyl anions, whereas SLC26A5 (prestin) was suggested to act as the motor protein of the cochlear outer hair cell.	Oxalates	206-213	solute carrier family 26 member 2	Homo sapiens	80-85
11087667-3	2000	Three human transporter proteins have been functionally characterized: SLC26A2 (DTDST), SLC26A3 (CLD or DRA), and SLC26A4 (PDS) can transport with different specificities the chloride, iodine, bicarbonate, oxalate, and hydroxyl anions, whereas SLC26A5 (prestin) was suggested to act as the motor protein of the cochlear outer hair cell.	Oxalates	206-213	solute carrier family 26 member 3	Homo sapiens	88-95
11087667-3	2000	Three human transporter proteins have been functionally characterized: SLC26A2 (DTDST), SLC26A3 (CLD or DRA), and SLC26A4 (PDS) can transport with different specificities the chloride, iodine, bicarbonate, oxalate, and hydroxyl anions, whereas SLC26A5 (prestin) was suggested to act as the motor protein of the cochlear outer hair cell.	Oxalates	206-213	solute carrier family 26 member 3	Homo sapiens	104-107
11087667-3	2000	Three human transporter proteins have been functionally characterized: SLC26A2 (DTDST), SLC26A3 (CLD or DRA), and SLC26A4 (PDS) can transport with different specificities the chloride, iodine, bicarbonate, oxalate, and hydroxyl anions, whereas SLC26A5 (prestin) was suggested to act as the motor protein of the cochlear outer hair cell.	Oxalates	206-213	solute carrier family 26 member 4	Homo sapiens	114-121
11087667-3	2000	Three human transporter proteins have been functionally characterized: SLC26A2 (DTDST), SLC26A3 (CLD or DRA), and SLC26A4 (PDS) can transport with different specificities the chloride, iodine, bicarbonate, oxalate, and hydroxyl anions, whereas SLC26A5 (prestin) was suggested to act as the motor protein of the cochlear outer hair cell.	Oxalates	206-213	solute carrier family 26 member 5	Homo sapiens	244-251
11087667-3	2000	Three human transporter proteins have been functionally characterized: SLC26A2 (DTDST), SLC26A3 (CLD or DRA), and SLC26A4 (PDS) can transport with different specificities the chloride, iodine, bicarbonate, oxalate, and hydroxyl anions, whereas SLC26A5 (prestin) was suggested to act as the motor protein of the cochlear outer hair cell.	Oxalates	206-213	solute carrier family 26 member 5	Homo sapiens	253-260
10916087-3	2000	Specifically, our studies assessed the possibility that oxalate-induced changes in IEG expression are mediated by phospholipase A2 (PLA2), a common pathway in cellular stress responses.	Oxalates	56-63	phospholipase A2 group IB	Canis lupus familiaris	114-130
10916087-3	2000	Specifically, our studies assessed the possibility that oxalate-induced changes in IEG expression are mediated by phospholipase A2 (PLA2), a common pathway in cellular stress responses.	Oxalates	56-63	phospholipase A2 group IB	Canis lupus familiaris	132-136
18968050-6	2000	The interfering effects among analytes ions, Fe(III), Co(II), Ni(II) and Cu(II) were more serious than by other ions, but the interfering effects could be removed by adjusting pH or adding the masking agents such as NH(3) or oxalate.	Oxalates	225-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
10916087-8	2000	Treatment with mepacrine resulted in a 75 to 113% reduction of oxalate-induced c-jun, egr-1, and c-myc mRNA, while AACOCF3 caused a 41 to 46% reduction of oxalate-induced c-jun and egr-1 mRNA.	Oxalates	63-70	early growth response 1	Canis lupus familiaris	86-91
10916087-8	2000	Treatment with mepacrine resulted in a 75 to 113% reduction of oxalate-induced c-jun, egr-1, and c-myc mRNA, while AACOCF3 caused a 41 to 46% reduction of oxalate-induced c-jun and egr-1 mRNA.	Oxalates	63-70	MYC proto-oncogene, bHLH transcription factor	Canis lupus familiaris	97-102
10916087-8	2000	Treatment with mepacrine resulted in a 75 to 113% reduction of oxalate-induced c-jun, egr-1, and c-myc mRNA, while AACOCF3 caused a 41 to 46% reduction of oxalate-induced c-jun and egr-1 mRNA.	Oxalates	155-162	Jun proto-oncogene, AP-1 transcription factor subunit	Canis lupus familiaris	171-176
10916087-10	2000	In contrast, AA (25 micromol/L) attenuated the oxalate-induced increase in c-jun and egr-1 mRNA, presumably by inhibiting PLA2 activity.	Oxalates	47-54	Jun proto-oncogene, AP-1 transcription factor subunit	Canis lupus familiaris	75-80
10916087-10	2000	In contrast, AA (25 micromol/L) attenuated the oxalate-induced increase in c-jun and egr-1 mRNA, presumably by inhibiting PLA2 activity.	Oxalates	47-54	early growth response 1	Canis lupus familiaris	85-90
10916087-10	2000	In contrast, AA (25 micromol/L) attenuated the oxalate-induced increase in c-jun and egr-1 mRNA, presumably by inhibiting PLA2 activity.	Oxalates	47-54	phospholipase A2 group IB	Canis lupus familiaris	122-126
10916087-11	2000	CONCLUSIONS: These findings suggest that PLA2 plays a major role in oxalate-induced IEG expression in renal epithelial cells and that lysophospholipids might be a possible lipid mediator in this pathway.	Oxalates	68-75	phospholipase A2 group IB	Canis lupus familiaris	41-45
11330044-1	2000	Glyoxylate is an immediate precursor of oxalate, but in its metabolism the conversion into glycine catalyzed by serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT) appears to be the main route.	Oxalates	40-47	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	165-168
10933316-1	2000	In primary hyperoxaluria type 1 (PH 1), deficiency or mistargeting of hepatic alanine glyoxylate aminotransferase (AGT) results in over-production of oxalate and hyperoxaluria, leading to nephrocalcinosis and development of end-stage renal disease (ESRD) in the majority of patients.	Oxalates	150-157	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	78-113
10933316-1	2000	In primary hyperoxaluria type 1 (PH 1), deficiency or mistargeting of hepatic alanine glyoxylate aminotransferase (AGT) results in over-production of oxalate and hyperoxaluria, leading to nephrocalcinosis and development of end-stage renal disease (ESRD) in the majority of patients.	Oxalates	150-157	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	115-118
10848711-7	2000	RESULTS: Urinary oxalate increased significantly and was associated with an increase in NAG and GAL at all sample times.	Oxalates	17-24	O-GlcNAcase	Rattus norvegicus	88-91
10848711-7	2000	RESULTS: Urinary oxalate increased significantly and was associated with an increase in NAG and GAL at all sample times.	Oxalates	17-24	galactosidase, beta 1	Rattus norvegicus	96-99
10844609-13	2000	The oxalate-induced increase in ceramide was also attenuated by pretreatment with AACOCF3, suggesting a role for PLA2.	Oxalates	4-11	phospholipase A2 group IB	Canis lupus familiaris	113-117
10844609-15	2000	CONCLUSIONS: Oxalate exposure produces a marked accumulation of ceramide in renal epithelial cells by a process that is redox sensitive and mediated in part by activation of PLA2.	Oxalates	13-20	phospholipase A2 group IB	Canis lupus familiaris	174-178
10777549-9	2000	The presence of HAOX1 in liver and kidney peroxisomes and the ability of HAOX1 to oxidize glyoxylate to oxalate implicate HAOX1 as a mediator of PH1 pathophysiology.	Oxalates	104-111	hydroxyacid oxidase 1	Homo sapiens	73-78
10777549-9	2000	The presence of HAOX1 in liver and kidney peroxisomes and the ability of HAOX1 to oxidize glyoxylate to oxalate implicate HAOX1 as a mediator of PH1 pathophysiology.	Oxalates	104-111	hydroxyacid oxidase 1	Homo sapiens	73-78
10637137-7	2000	The ability of bcl-2, an anti-apoptotic gene product, to attenuate oxalate toxicity was also assessed.	Oxalates	67-74	BCL2, apoptosis regulator	Rattus norvegicus	15-20
10637137-8	2000	These studies indicated that oxalate-induced death of renal epithelial cells exhibits several features characteristic of apoptotic cell death, including increased production of ceramide, increased abundance of apoptotic bodies, and marked sensitivity to the level of expression of the anti-apoptotic gene bcl-2.	Oxalates	29-36	BCL2, apoptosis regulator	Rattus norvegicus	305-310
10764774-7	2000	Similarly, the initial rate of (45)Ca(2+) influx into oxalate-loaded microsomal vesicles was inhibited by IP(3) only when the microsomes were prepared from COS cells doubly transfected with SERCA-2b and IP(3)R DNA.	Oxalates	54-61	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	203-209
10840464-0	2000	Free radical scavengers, catalase and superoxide dismutase provide protection from oxalate-associated injury to LLC-PK1 and MDCK cells.	Oxalates	83-90	catalase	Sus scrofa	25-33
11330044-1	2000	Glyoxylate is an immediate precursor of oxalate, but in its metabolism the conversion into glycine catalyzed by serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT) appears to be the main route.	Oxalates	40-47	angiotensinogen	Homo sapiens	169-172
11330044-2	2000	When SPT/AGT is missing as in the case of primary hyperoxaluria type 1 (PH1) more glyoxylate is used for the oxalate production, resulting in calcium oxalate urolithiasis and finally systemic oxalosis.	Oxalates	109-116	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	72-75
11330044-4	2000	For herbivores, the peroxisomal localization of SPT/AGT is indispensable to avoid massive production of oxalate, probably because liver peroxisomes are the main site of glyoxylate production from glycolate, and plants contain glycolate much more than animal tissues.	Oxalates	104-111	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	48-51
11330044-4	2000	For herbivores, the peroxisomal localization of SPT/AGT is indispensable to avoid massive production of oxalate, probably because liver peroxisomes are the main site of glyoxylate production from glycolate, and plants contain glycolate much more than animal tissues.	Oxalates	104-111	angiotensinogen	Homo sapiens	52-55
10541256-3	1999	Injecting CRF rats with a specific angiotensin II (AngII) receptor (AT1) antagonist, losartan, results in a reversal of the CRF-induced net secretory flux (-13.87+/-0.08 pmol x cm(-2) x h(-1)) to an absorptive flux (+7.32+/-3.68 pmol x cm(-2) x h(-1)) by normalizing the unidirectional fluxes of oxalate.	Oxalates	296-303	angiotensinogen	Rattus norvegicus	51-56
11156700-8	2000	Therefore, peroxisomal localization of SPT/AGT may be indispensable for herbivores to convert the glyoxylate formed in peroxisomes into glycine in situ rather than forming oxalate.	Oxalates	172-179	angiotensinogen	Homo sapiens	43-46
11156703-1	2000	Primary hyperoxaluria Type II (PH2) is a rare monogenic disease characterized by excessive urinary oxalate and L-glycerate excretion.	Oxalates	99-106	glyoxylate and hydroxypyruvate reductase	Homo sapiens	31-34
11156705-5	2000	In LLC-PK1 and MDCK cells, oxalate exposure produces marked effects on membranes, causing a redistribution of phosphatidylserine and activation of two lipid signaling cascades, one involving phospholipase A(2) (PLA(2)) and one involving ceramide.	Oxalates	27-34	phospholipase A2 group IB	Canis lupus familiaris	191-209
11156705-5	2000	In LLC-PK1 and MDCK cells, oxalate exposure produces marked effects on membranes, causing a redistribution of phosphatidylserine and activation of two lipid signaling cascades, one involving phospholipase A(2) (PLA(2)) and one involving ceramide.	Oxalates	27-34	phospholipase A2 group IB	Canis lupus familiaris	211-217
10603104-1	1999	Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disorder characterised by an increased urinary excretion of calcium oxalate, leading to recurrent urolithiasis, nephrocalcinosis and accumulation of insoluble oxalate throughout the body (oxalosis) when the glomerular filtration rate falls to below 40-20 mL/min per 1.73 m(2).	Oxalates	133-140	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
10638699-0	2000	Dietary manipulation of delta-6-desaturase modifies phospholipid arachidonic acid levels and the urinary excretion of calcium and oxalate in the rat: insight in calcium lithogenesis.	Oxalates	130-137	fatty acid desaturase 2	Rattus norvegicus	24-42
10541256-3	1999	Injecting CRF rats with a specific angiotensin II (AngII) receptor (AT1) antagonist, losartan, results in a reversal of the CRF-induced net secretory flux (-13.87+/-0.08 pmol x cm(-2) x h(-1)) to an absorptive flux (+7.32+/-3.68 pmol x cm(-2) x h(-1)) by normalizing the unidirectional fluxes of oxalate.	Oxalates	296-303	angiotensin II receptor, type 1a	Rattus norvegicus	68-71
10541256-6	1999	Serosal application of AngII at 10(-6), 10(-5), and 10(-4) M resulted in significant increases in the s-->m flux of oxalate (increasing deltaJsm = 4.06+/-1.2, 8.41+/-0.94, and 13.8+/-3.8 pmol x cm(-2) x h(-1), respectively).	Oxalates	119-126	angiotensinogen	Rattus norvegicus	23-28
10541281-4	1999	Oxalate-induced changes were also assessed in the expression of two genes: egr-1, a zinc-finger transcription factor, and osteopontin, a protein associated with tissue remodeling.	Oxalates	0-7	early growth response 1	Homo sapiens	75-116
10541281-4	1999	Oxalate-induced changes were also assessed in the expression of two genes: egr-1, a zinc-finger transcription factor, and osteopontin, a protein associated with tissue remodeling.	Oxalates	0-7	secreted phosphoprotein 1	Homo sapiens	122-133
10541281-9	1999	This mitogenic effect offset cell loss at lower oxalate concentrations (88 microM) leading to a small but significant increase in cell number at 72 h. Treatment with oxalate also increased expression of egr-1 mRNA within 1 h, a response that was attenuated by MnTMPyP; oxalate treatment for 8 h also increased abundance of osteopontin mRNA.	Oxalates	166-173	early growth response 1	Homo sapiens	203-208
10541281-9	1999	This mitogenic effect offset cell loss at lower oxalate concentrations (88 microM) leading to a small but significant increase in cell number at 72 h. Treatment with oxalate also increased expression of egr-1 mRNA within 1 h, a response that was attenuated by MnTMPyP; oxalate treatment for 8 h also increased abundance of osteopontin mRNA.	Oxalates	166-173	secreted phosphoprotein 1	Homo sapiens	323-334
10541281-9	1999	This mitogenic effect offset cell loss at lower oxalate concentrations (88 microM) leading to a small but significant increase in cell number at 72 h. Treatment with oxalate also increased expression of egr-1 mRNA within 1 h, a response that was attenuated by MnTMPyP; oxalate treatment for 8 h also increased abundance of osteopontin mRNA.	Oxalates	166-173	early growth response 1	Homo sapiens	203-208
10541281-9	1999	This mitogenic effect offset cell loss at lower oxalate concentrations (88 microM) leading to a small but significant increase in cell number at 72 h. Treatment with oxalate also increased expression of egr-1 mRNA within 1 h, a response that was attenuated by MnTMPyP; oxalate treatment for 8 h also increased abundance of osteopontin mRNA.	Oxalates	166-173	secreted phosphoprotein 1	Homo sapiens	323-334
10492241-0	1999	Expression of bikunin mRNA in renal epithelial cells after oxalate exposure.	Oxalates	59-66	serine peptidase inhibitor, Kunitz type 2	Canis lupus familiaris	14-21
10493928-1	1999	Oxalate oxidase (EC 1.2.3.4) catalyses the conversion of oxalate and dioxygen into CO(2) and H(2)O(2).	Oxalates	57-64	LOC548260	Hordeum vulgare	0-15
10504495-0	1999	Role of phospholipase A2 in the cytotoxic effects of oxalate in cultured renal epithelial cells.	Oxalates	53-60	phospholipase A2 group IB	Canis lupus familiaris	8-24
10504495-3	1999	Thus, these studies examined the role of PLA2 in the cytotoxic effects of oxalate.	Oxalates	74-81	phospholipase A2 group IB	Canis lupus familiaris	41-45
10504495-7	1999	Oxalate-induced [3H]-AA release was abolished by arachidonyl trifluoromethyl ketone (AACOCF3), a selective inhibitor of cytosolic PLA2 (cPLA2), but was not affected by selective inhibitors of secretory PLA2 and calcium-independent PLA2.	Oxalates	0-7	phospholipase A2 group IB	Canis lupus familiaris	130-134
10504495-7	1999	Oxalate-induced [3H]-AA release was abolished by arachidonyl trifluoromethyl ketone (AACOCF3), a selective inhibitor of cytosolic PLA2 (cPLA2), but was not affected by selective inhibitors of secretory PLA2 and calcium-independent PLA2.	Oxalates	0-7	phospholipase A2 group IB	Canis lupus familiaris	137-141
10492241-1	1999	PURPOSE: To determine the changes in expression of bikunin in renal epithelial cells on exposure to oxalate and calcium oxalate crystals.	Oxalates	100-107	serine peptidase inhibitor, Kunitz type 2	Canis lupus familiaris	51-58
10492241-2	1999	MATERIALS AND METHODS: This study used reverse transcription polymerase chain reaction (RT-PCR) to examine bikunin mRNA expression levels in MDCK cells exposed to oxalate or calcium oxalate crystals.	Oxalates	163-170	serine peptidase inhibitor, Kunitz type 2	Canis lupus familiaris	107-114
10492241-9	1999	Bikunin expression was significantly increased in oxalate exposed cells.	Oxalates	50-57	serine peptidase inhibitor, Kunitz type 2	Canis lupus familiaris	0-7
10492241-11	1999	Western blotting analysis also showed increased expression of bikunin and inter-alpha-inhibitor-related proteins in the culture medium of oxalate exposed cells.	Oxalates	138-145	serine peptidase inhibitor, Kunitz type 2	Canis lupus familiaris	62-69
10492241-12	1999	CONCLUSIONS: These findings suggest that renal epithelial cells express bikunin gene and have the capability to produce bikunin when stimulated by certain agents such as oxalate.	Oxalates	170-177	serine peptidase inhibitor, Kunitz type 2	Canis lupus familiaris	72-79
10492241-12	1999	CONCLUSIONS: These findings suggest that renal epithelial cells express bikunin gene and have the capability to produce bikunin when stimulated by certain agents such as oxalate.	Oxalates	170-177	serine peptidase inhibitor, Kunitz type 2	Canis lupus familiaris	120-127
10492241-13	1999	This increased expression and production of bikunin may represent a protective response of renal epithelial cells to nephrotoxic challenges of oxalate.	Oxalates	143-150	serine peptidase inhibitor, Kunitz type 2	Canis lupus familiaris	44-51
10504495-7	1999	Oxalate-induced [3H]-AA release was abolished by arachidonyl trifluoromethyl ketone (AACOCF3), a selective inhibitor of cytosolic PLA2 (cPLA2), but was not affected by selective inhibitors of secretory PLA2 and calcium-independent PLA2.	Oxalates	0-7	phospholipase A2 group IB	Canis lupus familiaris	137-141
10411702-1	1999	BACKGROUND: Children with primary hyperoxaluria type 1 (PH 1) are at great risk to develop systemic oxalosis in end-stage renal disease (ESRD), as endogenous oxalate production exceeds oxalate removal by dialytic therapy.	Oxalates	158-165	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	56-60
10485304-4	1999	Excessive Uox concentrations after surgery might have been due to a bone pool of unsoluble oxalate and declined spontaneously.	Oxalates	91-98	urate oxidase (pseudogene)	Homo sapiens	10-13
10409492-7	1999	NaSi-1 specificity for the Na(+) cation was determined, and the anions selenate, molybdate, tungstate, oxalate and thiosulphate could all inhibit NaSi-1-induced sulphate transport.	Oxalates	103-110	solute carrier family 13 member 1 S homeolog	Xenopus laevis	146-152
10411702-1	1999	BACKGROUND: Children with primary hyperoxaluria type 1 (PH 1) are at great risk to develop systemic oxalosis in end-stage renal disease (ESRD), as endogenous oxalate production exceeds oxalate removal by dialytic therapy.	Oxalates	185-192	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	56-60
10609297-3	1999	In the presence of 10 mM oxalate the values of the activation constant KMg for Mg2+ and K(m) for ATP were 0.6 and 1.0 mM, respectively.	Oxalates	25-32	mucin 7, secreted	Homo sapiens	79-82
9804183-1	1998	A new glyoxylate dehydrogenase which catalyzes dehydrogenation of glyoxylate to oxalate in the presence of cytochrome c has been purified as an electrophoretically homogeneous protein from the cell-free extracts of a wood-destroying basidiomycete Tyromyces palustris.	Oxalates	80-87	cytochrome c, somatic	Homo sapiens	107-119
9823023-4	1998	Coexpression of SERCA2 and PLB in CM was supported by measurement of cell homogenate oxalate-supported Ca2+ uptake which was completely inhibited by thapsigargin and stimulated by protein kinase A-catalyzed phosphorylation.	Oxalates	85-92	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	16-22
9823023-4	1998	Coexpression of SERCA2 and PLB in CM was supported by measurement of cell homogenate oxalate-supported Ca2+ uptake which was completely inhibited by thapsigargin and stimulated by protein kinase A-catalyzed phosphorylation.	Oxalates	85-92	phospholamban	Rattus norvegicus	27-30
9915480-13	1999	Although difference in GO activity has no physiological effect on oxalate synthesis, GO activity affects urinary oxalate excretion during ethylene glycol loading.	Oxalates	113-120	hydroxyacid oxidase 1	Rattus norvegicus	85-87
9623638-1	1998	insulin bolus on urinary calcium and oxalate excretion in healthy subjects.	Oxalates	37-44	insulin	Homo sapiens	0-7
9761503-5	1998	RESULTS: Compared with the free-choice diet (322+/-36 micromol/d), UOx x V increased to 780+/-72 micromol/d on the oxalate-rich diet (P=0.001) and fell again to 326+/-31 micromol/d on calcium and oxalate-rich diet (P=0.001 vs oxalate-rich diet).	Oxalates	115-122	urate oxidase (pseudogene)	Homo sapiens	67-70
9689008-1	1998	The rat liver sulfate/bicarbonate/oxalate exchanger (sat-1) transports sulfate across the canalicular membrane in exchange for either bicarbonate or oxalate.	Oxalates	34-41	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	53-58
9689008-5	1998	Sodium-independent sulfate and oxalate uptake was enhanced 7.3-fold and 13.1-fold, respectively, in Sf9 cells expressing the sat-1 protein compared with cells infected with wild-type virus.	Oxalates	31-38	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	125-130
10603935-10	1998	Infection of such myocytes with a SERCA2 expressing adenovirus could reconstitute the Ca2+ transient, and augmented oxalate facilitated SERCA2 Ca2+ uptake.	Oxalates	116-123	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	34-40
10603935-10	1998	Infection of such myocytes with a SERCA2 expressing adenovirus could reconstitute the Ca2+ transient, and augmented oxalate facilitated SERCA2 Ca2+ uptake.	Oxalates	116-123	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	136-142
9573560-1	1998	Primary hyperoxaluria type I (PH I) is a congenital error of metabolism that can be manifested by an increased oxalate production, and ultimately result in kidney failure.	Oxalates	111-118	glucose-6-phosphate isomerase	Homo sapiens	0-28
9573560-1	1998	Primary hyperoxaluria type I (PH I) is a congenital error of metabolism that can be manifested by an increased oxalate production, and ultimately result in kidney failure.	Oxalates	111-118	glucose-6-phosphate isomerase	Homo sapiens	30-34
9573560-2	1998	After a combined liver/kidney transplantation, children with PH I have persistent excretion of oxalate that causes crystal formation in the urinary tract, and could result in systemic oxalosis and eventual graft failure.	Oxalates	95-102	glucose-6-phosphate isomerase	Homo sapiens	61-65
9365788-1	1997	Defects in the AGXT gene mapped to chromosome 2q37.3 cause primary hyperoxaluria type 1 (PH1), one of the inherited disorders of endogenous oxalate overproduction.	Oxalates	140-147	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	15-19
9482116-2	1998	This finding was in accordance with previous works showing that DRA encodes a sodium independent transporter for sulfate and oxalate.	Oxalates	125-132	solute carrier family 26 member 3	Homo sapiens	64-67
9540839-2	1997	In these animals, the hepatic and kidney activities of oxalate synthesising enzymes such as lactate dehydrogenase and glycolate oxidase were normal, but tissue lipid peroxidation was significantly higher.	Oxalates	55-62	hydroxyacid oxidase 1	Rattus norvegicus	118-135
9540839-3	1997	In vitro experiments established that in a mild alkaline solution, hydroxypyruvate underwent auto-oxidation to form oxalate and H2O2 and also inhibited lactate dehydrogenase and glycolate oxidase from oxidising glyoxylate to oxalate.	Oxalates	225-232	hydroxyacid oxidase 1	Rattus norvegicus	178-195
9244202-7	1997	A 34.5% augmentation of oxalate-facilitated SR Ca2+ uptake was also documented in SERCA2 adenovirus-infected cells (P<.05).	Oxalates	24-31	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	82-88
9870291-5	1998	A positive correlation between NAG and oxalate excretion was observed in female patients (r = 0.56: P < 0.01).	Oxalates	39-46	O-GlcNAcase	Homo sapiens	31-34
9365788-1	1997	Defects in the AGXT gene mapped to chromosome 2q37.3 cause primary hyperoxaluria type 1 (PH1), one of the inherited disorders of endogenous oxalate overproduction.	Oxalates	140-147	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	89-92
9002528-2	1997	Primary hyperoxaluria type 1 is characterized by the elevated urinary excretion of oxalate and glycolate, and the deposition of insoluble calcium oxalate in the renal parenchyma and urinary tract.	Oxalates	83-90	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	0-28
9008022-8	1996	In the case of increased NAG excretion in stone patients there was a positive correlation between NAG excretion and increased phosphate, sulphate, uric acid, oxalate, and creatinine excretion.	Oxalates	158-165	O-GlcNAcase	Homo sapiens	25-28
9008022-8	1996	In the case of increased NAG excretion in stone patients there was a positive correlation between NAG excretion and increased phosphate, sulphate, uric acid, oxalate, and creatinine excretion.	Oxalates	158-165	O-GlcNAcase	Homo sapiens	98-101
8810298-3	1996	In this paper, we examine the mitochondrial transport of alpha, omega-dicarboxylates ranging from oxalate (DC2) to sebacate (DC10).	Oxalates	98-105	monoacylglycerol O-acyltransferase 1	Homo sapiens	107-110
8914018-0	1996	Activation of c-myc gene mediates the mitogenic effects of oxalate in LLC-PK1 cells, a line of renal epithelial cells.	Oxalates	59-66	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	14-19
8914018-2	1996	Exposure to oxalate initiates DNA synthesis, induces the expression of one of the early growth response genes c-myc and stimulates proliferation of quiescent cultures of LLC-PK1 cells.	Oxalates	12-19	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	110-115
8914018-4	1996	Specifically we determined whether pretreatment with c-myc antisense oligonucleotides would block the proliferative effects of oxalate in LLC-PK1 cells.	Oxalates	127-134	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	53-58
8914018-5	1996	Quiescent cultures of LLC-PK1 cells were exposed to oxalate in the presence and absence of c-myc antisense and the effects of oxalate on c-myc protein expression (Myc), DNA synthesis and cell growth were assessed.	Oxalates	126-133	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	137-142
8914018-6	1996	Exposure of cells to oxalate alone increased the expression of Myc within two hours.	Oxalates	21-28	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	63-66
8914018-8	1996	Further, pretreatment of cells with c-myc antisense but not nonsense oligonucleotides blocked the oxalate-induced initiation of DNA synthesis.	Oxalates	98-105	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	36-41
8914018-9	1996	Increases in cell number in response to oxalate (measured after 72 hr exposure) were also blocked by exposure to c-myc antisense.	Oxalates	40-47	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	113-118
8914018-10	1996	These findings suggest that c-myc gene expression is critical for the mitogenic effects of oxalate in LLC-PK1 cells.	Oxalates	91-98	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	28-33
8760044-10	1996	Preincubating the membranes in MgATP2- in the presence of Ca2+/calmodulin stimulated the subsequent Ca2+ uptake in the presence of oxalate plus MgATP2- and azide.	Oxalates	131-138	calmodulin-3	Sus scrofa	63-73
8832145-18	1996	Urinary oxalate/creatinine ratio was 705 mumol/mol and gave rise to the diagnosis of PH 1.	Oxalates	8-15	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	85-89
12226325-3	1996	Germin is a protein marker for early cereal development and is an oxalate oxidase, an enzyme that catalyzes the conversion of oxalate to CO2 and H2O2.	Oxalates	66-73	oxalate oxidase 2	Triticum aestivum	0-6
8724896-9	1996	Phospholipase A2 increased the erythrocyte anion-carrier protein phosphorylation and the oxalate exchange.	Oxalates	89-96	phospholipase A2 group IB	Homo sapiens	0-16
8683457-16	1996	In contrast, 20 mM oxalate increased Ca2+ uptake and the [Ca2+] within the bath continued to fall over 2-3 min.	Oxalates	19-26	carbonic anhydrase 2	Rattus norvegicus	58-61
11666358-7	1996	Furthermore, it seemed likely that 1,2-dithiooxalate (dto) could act as an alternative to the oxalate bridging ligand, and as a result the compound [Ni(II)(phen)(3)][NaCo(III)(dto)(3)].C(3)H(6)O (5) has successfully been isolated and structurally characterized.	Oxalates	45-52	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	171-174
8821825-7	1996	Specifically, addition of catalase or superoxide dismutase blocked the oxalate-induced changes in dye fluorescence/absorbance.	Oxalates	71-78	catalase	Sus scrofa	26-34
8683457-0	1996	Comparative effects of inorganic phosphate and oxalate on uptake and release of Ca2+ by the sarcoplasmic reticulum in saponin skinned rat cardiac trabeculae.	Oxalates	47-54	carbonic anhydrase 2	Rattus norvegicus	80-83
8683457-8	1996	Caffeine-induced Ca2+ transients were also reduced in the presence of 10 mM oxalate, although this effect was not reversed by CP.	Oxalates	76-83	carbonic anhydrase 2	Rattus norvegicus	17-20
8683457-11	1996	However, when the flow was stopped in the presence of 60 mM Pi and 10 mM CP, a prolonged decrease in [Ca2+] occurred, consistent with precipitation of calcium phosphate within the SR. A similar decrease in [Ca2+] was observed when perfusion was stopped in the presence of 2 or 20 mM oxalate, in the absence or presence of CP.	Oxalates	283-290	carbonic anhydrase 2	Rattus norvegicus	102-105
8683457-16	1996	In contrast, 20 mM oxalate increased Ca2+ uptake and the [Ca2+] within the bath continued to fall over 2-3 min.	Oxalates	19-26	carbonic anhydrase 2	Rattus norvegicus	37-40
7744840-4	1995	We established that dra encodes for a Na(+)-independent transporter for both sulfate and oxalate using microinjected Xenopus oocytes as an assay system.	Oxalates	89-96	solute carrier family 26 member 3	Homo sapiens	20-23
7578099-1	1995	The binding of the two synergistic anion mimics, phosphate and sulfate, and of the synergistic anions, malonate and oxalate, to the N-lobe of recombinant human serum transferrin (hTF/2N) wild-type and H207E mutant protein was assessed by difference ultraviolet (UV) spectroscopy at 246 nm as a function of pH.	Oxalates	116-123	transferrin	Homo sapiens	166-177
8835944-3	1996	Oxalate caused non-competitive inhibition (Ki app = IC50 = 0.15 mM) of the forward reaction, NADH was more effective in blocking inhibition by GAA than pyruvate.	Oxalates	0-7	alpha glucosidase	Homo sapiens	143-146
8549069-5	1995	Urinary prothrombin F1 was purified from demineralized calcium oxalate crystals precipitated from human urine, and its effects on calcium oxalate crystallization induced by addition of an oxalate load were tested in undiluted, ultrafiltered urine from healthy men, at final concentrations of 0 to 10 mg/l.	Oxalates	63-70	coagulation factor II, thrombin	Homo sapiens	8-19
7580055-6	1995	In contrast, loading of transferrin with aluminum in the presence of oxalate produces a di-aluminum-transferrin complex that is stable during IEF.	Oxalates	69-76	transferrin	Homo sapiens	24-35
7580055-6	1995	In contrast, loading of transferrin with aluminum in the presence of oxalate produces a di-aluminum-transferrin complex that is stable during IEF.	Oxalates	69-76	transferrin	Homo sapiens	100-111
7759481-3	1995	Ternary complexes of periodate-modified transferrin and either Fe(III) with nitrilotriacetate (NTA), oxalate, citrate, or EDTA, or of Cu(II) with oxalate could be formed.	Oxalates	101-108	transferrin	Homo sapiens	40-51
7998986-4	1994	Ca2+ accumulation at nM concentrations of free Ca2+ was inhibited by thapsigargin and inositol 1,4,5-triphosphate [Ins(1,4,5)P3], enhanced by oxalate and unaffected by oligomycin.	Oxalates	142-149	carbonic anhydrase 2	Rattus norvegicus	0-3
7742085-5	1995	Iliac crest biopsy revealed large numbers of oxalate crystals in the bone marrow, many of which were associated with macrophages, identified using the antibody MAC 387.	Oxalates	45-52	S100 calcium binding protein A9	Homo sapiens	160-167
8592622-2	1995	Primary hyperoxaluria type 1 (PH1) always leads to oxalate accumulation throughout the body (oxalosis).	Oxalates	51-58	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
7998986-4	1994	Ca2+ accumulation at nM concentrations of free Ca2+ was inhibited by thapsigargin and inositol 1,4,5-triphosphate [Ins(1,4,5)P3], enhanced by oxalate and unaffected by oligomycin.	Oxalates	142-149	carbonic anhydrase 2	Rattus norvegicus	47-50
8020468-17	1994	In the absence of dioxygen, NOR was quantitatively reduced by either sodium dithionite, or photochemically with deazaflavin and oxalate; the enzyme was reoxidizable by ferricyanide in a fully reversible reaction.	Oxalates	128-135	cbb3-type cytochrome c oxidase subunit I	Pseudomonas stutzeri	28-31
8136366-8	1994	When oxalate is used as the anion instead of carbonate, the 205Tl NMR signals arising from the bound metal ion in the sites of ovotransferrin are shifted downfield and become almost degenerate.	Oxalates	5-12	transferrin (ovotransferrin)	Gallus gallus	127-141
8311084-2	1994	Deficiencies of D-glycerate dehydrogenase and glyoxylate reductase activity in patients with this disorder leads to increases in urinary oxalate and glycerate excretion.	Oxalates	137-144	glyoxylate and hydroxypyruvate reductase	Homo sapiens	46-66
8136366-1	1994	We have examined the binding of Tl3+ to human serotransferrin and chicken ovotransferrin in the presence of carbonate and oxalate by 205Tl and 13C NMR spectroscopy.	Oxalates	122-129	transferrin	Homo sapiens	46-61
7762444-6	1994	Both the carbonate and oxalate ions bind in bidentate fashion to the metal, except that the carbonate ion in the N-lobe site of dicupric lactoferrin is monodentate.	Oxalates	23-30	lactotransferrin	Bos taurus	137-148
8300633-2	1994	The cloned cDNA sulfate anion transporter-1 (sat-1) expresses saturable Na(+)-independent sulfate uptake (Km approximately 0.14 mM) that can be inhibited by 4,4"-diisothiocyano-2,2"-disulfonic acid stilbene (DIDS, IC50 = 28 microM) and oxalate, but not by succinate or cholate.	Oxalates	236-243	solute carrier family 26 member 1	Rattus norvegicus	16-43
8300633-2	1994	The cloned cDNA sulfate anion transporter-1 (sat-1) expresses saturable Na(+)-independent sulfate uptake (Km approximately 0.14 mM) that can be inhibited by 4,4"-diisothiocyano-2,2"-disulfonic acid stilbene (DIDS, IC50 = 28 microM) and oxalate, but not by succinate or cholate.	Oxalates	236-243	solute carrier family 26 member 1	Rattus norvegicus	45-50
7762444-7	1994	The hybrid copper lactoferrin complex shows that the oxalate ion binds preferentially in the C-lobe site in a bidentate mode.	Oxalates	53-60	lactotransferrin	Bos taurus	18-29
8311474-1	1994	The spectral and magnetic properties of iron(III) bound in the metal binding sites of human serum transferrin with oxalate or bicarbonate as synergistic anions has been studied with Mossbauer spectroscopy and electron paramagnetic resonance (EPR).	Oxalates	115-122	transferrin	Homo sapiens	98-109
8311474-2	1994	The Mossbauer spectra of the iron(III) in diferric transferrin with oxalate have been described using a spin Hamiltonian with the values of the zero field splitting parameter, D = 0.55 +/- 0.05 cm-1, and the rhombicity of the crystal field, E/D = 0.045 +/- 0.005.	Oxalates	68-75	transferrin	Homo sapiens	51-62
8311474-4	1994	The rhombicity of the iron surroundings for the transferrin-oxalate complex is almost one order of magnitude smaller than for the bicarbonate complex and the zero field splitting parameter is twice as large in the oxalate as in the bicarbonate complex.	Oxalates	60-67	transferrin	Homo sapiens	48-59
8311474-4	1994	The rhombicity of the iron surroundings for the transferrin-oxalate complex is almost one order of magnitude smaller than for the bicarbonate complex and the zero field splitting parameter is twice as large in the oxalate as in the bicarbonate complex.	Oxalates	214-221	transferrin	Homo sapiens	48-59
8144172-1	1993	A biosensor for the specific determination of oxalate was developed using oxalate oxidase (EC 1.2.3.4) from barley (Hordeum vulgare) seedling roots in combination with a dissolved oxygen probe.	Oxalates	46-53	LOC548260	Hordeum vulgare	74-89
8051936-3	1994	Activity of the liver-specific peroxisomal enzyme alanine:-glyoxylate aminotransferase (AGT), which is a major determinant of the level of endogenous oxalate synthesis in humans, was normal in one patient and markedly supranormal in the other.	Oxalates	150-157	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	50-86
8051936-3	1994	Activity of the liver-specific peroxisomal enzyme alanine:-glyoxylate aminotransferase (AGT), which is a major determinant of the level of endogenous oxalate synthesis in humans, was normal in one patient and markedly supranormal in the other.	Oxalates	150-157	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	88-91
8144172-3	1993	The electrode response was maximum when 50 mM succinate buffer was used at pH 3.2 and 35 degrees C. The biosensor response depends linearly on oxalate concentration between 5 x 10(-6)-2 x 10(-4) M with response time 30 sec and substrate specificity of the oxalate oxidase electrode of 100%.	Oxalates	143-150	LOC548260	Hordeum vulgare	256-271
8509360-7	1993	Roles for germin in cell wall biochemistry and tissue remodeling are discussed, with special emphasis on the generation of hydrogen peroxide during germin-induced oxidation of oxalate.	Oxalates	176-183	oxalate oxidase 2	Triticum aestivum	148-154
8104917-6	1993	D-Amino acid oxidase may play a role in vivo in the production of oxalate which may participate in metabolic control processes as an intracellular messenger molecule.	Oxalates	66-73	D-amino-acid oxidase	Rattus norvegicus	0-20
1311162-11	1992	A titration of Mg2+ with PK in the presence of the inhibitor oxalate gives a 1/T2 of 400 s-1.	Oxalates	61-68	pyruvate kinase PKLR	Oryctolagus cuniculus	25-27
8345725-4	1993	The data suggest the possibility that it should be consistent with at least two transport systems for oxalate in LLC-PK1 cells, a SO4-/oxalate/HCO3- exchanger and a Cl-/oxalate exchanger.	Oxalates	102-109	HCO3	Sus scrofa	143-147
8461302-0	1993	Oxalate- and Ga(3+)-induced structural changes in human serum transferrin and its recombinant N-lobe.	Oxalates	0-7	transferrin	Homo sapiens	62-73
8461302-2	1993	(1) The binding of the synergistic anion oxalate and Ga3+ to human serum transferrin (HTF, 80 kDa) and its recombinant N-lobe (HTF/2N, 40 kDa) has been studied by one- and two-dimensional 1H NMR spectroscopy, at 310 K, pH*7.25.	Oxalates	41-48	transferrin	Homo sapiens	73-84
8476723-1	1993	Primary hyperoxaluria type 1 (PH1) is a rare recessive autosomal inborn error of glyoxylate metabolism leading to oxalate retention, the first target of which is the kidney.	Oxalates	114-121	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
8476723-4	1993	The current experience of the management of PH1 has emphasized two main points: (1) end-stage renal failure must be avoided since it increases dramatically the risk of systemic involvement, (2) the correction of oxalate overproduction and organ overload requires the removal of the host liver.	Oxalates	212-219	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	44-47
8450916-4	1993	The diagnosis of PH1 has been recently confirmed despite the patient being already anuric by means of the determination of plasma oxalate and glycolate levels as well as by determining hepatic alanine:glyoxylate amino-transferase.	Oxalates	130-137	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	17-20
1337585-2	1992	Virtually all previous studies of cardiac SR Ca2+ transport were performed in the presence of oxalate, a dicarboxylic anion that is cotransported with Ca2+ in skeletal muscle SR.	Oxalates	94-101	carbonic anhydrase 2	Oryctolagus cuniculus	45-48
1337585-2	1992	Virtually all previous studies of cardiac SR Ca2+ transport were performed in the presence of oxalate, a dicarboxylic anion that is cotransported with Ca2+ in skeletal muscle SR.	Oxalates	94-101	carbonic anhydrase 2	Oryctolagus cuniculus	151-154
1633155-7	1992	Highly synergistic inhibition of phosphoenolpyruvate carboxylase was observed in the presence of oxalate and carbamyl phosphate (alpha = 0.0013).	Oxalates	97-104	MLO-like protein 4	Zea mays	33-64
1873359-7	1991	The oxalate/NaF and EDTA systems were both appropriate, as appeared from the observed blockade of the production of TNF in the tube, either in the cell-glycolysis-blocked or in the calcium-depleted situation, respectively.	Oxalates	4-11	tumor necrosis factor	Homo sapiens	116-119
1312207-3	1992	Using methods for isolating both calsequestrin and calreticulin, we have isolated a 58 kDa, high capacity calcium binding protein that exists in microsomes that shift their density in an oxalate-mediated density shift assay.	Oxalates	187-194	calreticulin	Bos taurus	51-63
1663741-5	1991	Catalase inhibited both Fe(2+)-H2O2 induced oxalate binding and lipid peroxidation reactions, suggesting that the induced oxalate binding in mitochondria was mediated through the hydroxyl radical reaction mechanism.	Oxalates	44-51	catalase	Rattus norvegicus	0-8
1663741-5	1991	Catalase inhibited both Fe(2+)-H2O2 induced oxalate binding and lipid peroxidation reactions, suggesting that the induced oxalate binding in mitochondria was mediated through the hydroxyl radical reaction mechanism.	Oxalates	122-129	catalase	Rattus norvegicus	0-8
1645201-6	1991	For oxalate and pyrophosphate, Mg2+ binding inhibits transport.	Oxalates	4-11	mucin 7, secreted	Homo sapiens	31-34
1873359-8	1991	An eventual decrease in the recovery of rTNF after collection of blood was prevented in the oxalate/NaF tubes.	Oxalates	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
1993340-3	1991	The most significant difference between concentrations found in plasma and serum was seen with oxalate/fluoride anticoagulant, which reduced osteocalcin concentrations to 37.3% of serum values.	Oxalates	95-102	bone gamma-carboxyglutamate protein	Homo sapiens	141-152
1825465-3	1991	The InsP3-insensitive Ca2+ store, which was also GTP insensitive, had a much lower Ca2+ affinity and presented a low oxalate permeability.	Oxalates	117-124	carbonic anhydrase 2	Homo sapiens	22-25
1825465-2	1991	The InsP3-sensitive Ca2+ pool, which was also GTP sensitive, had a high Ca2+ affinity and was highly oxalate permeable.	Oxalates	101-108	carbonic anhydrase 2	Homo sapiens	20-23
2173703-4	1990	In this work, we report that, when complexed with Mg2+, two endogenous dicarboxylic keto acids (alpha-ketoglutarate (alpha-KG) and oxaloacetate (OAA] inhibit the glucose-6-phosphatase activity at low concentrations of substrate.	Oxalates	145-148	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	162-183
2176593-3	1990	The two resonances at 168.5 and 169.9 ppm observed in the 13C-NMR spectrum of the Cd2 derivative obtained with [13C]oxalate each correspond to slowly exchanging oxalate specifically bound to a single site.	Oxalates	116-123	CD2 molecule	Homo sapiens	82-85
2176593-5	1990	It was found that the metal sites in the present derivative are inequivalent, as observed for other metal-transferrin-oxalate adducts.	Oxalates	118-125	transferrin	Homo sapiens	106-117
2173703-5	1990	This phenomenon is specific for complexes of Mg2+ with alpha-KG and OAA since 1) the complexes of Mg2+ with a number of other di- or tricarboxylic acids having high structural analogy with alpha-KG and OAA (oxalate, malate, succinate, citrate, aspartate, and glutamate) do not inhibit the glucose-6-phosphatase activity and 2) the Ca.alpha-KG and Ca.OAA chelates do not inhibit the glucose-6-phosphatase activity.	Oxalates	68-71	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	382-403
2173703-5	1990	This phenomenon is specific for complexes of Mg2+ with alpha-KG and OAA since 1) the complexes of Mg2+ with a number of other di- or tricarboxylic acids having high structural analogy with alpha-KG and OAA (oxalate, malate, succinate, citrate, aspartate, and glutamate) do not inhibit the glucose-6-phosphatase activity and 2) the Ca.alpha-KG and Ca.OAA chelates do not inhibit the glucose-6-phosphatase activity.	Oxalates	68-71	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	289-310
2173703-5	1990	This phenomenon is specific for complexes of Mg2+ with alpha-KG and OAA since 1) the complexes of Mg2+ with a number of other di- or tricarboxylic acids having high structural analogy with alpha-KG and OAA (oxalate, malate, succinate, citrate, aspartate, and glutamate) do not inhibit the glucose-6-phosphatase activity and 2) the Ca.alpha-KG and Ca.OAA chelates do not inhibit the glucose-6-phosphatase activity.	Oxalates	207-214	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	289-310
2173703-5	1990	This phenomenon is specific for complexes of Mg2+ with alpha-KG and OAA since 1) the complexes of Mg2+ with a number of other di- or tricarboxylic acids having high structural analogy with alpha-KG and OAA (oxalate, malate, succinate, citrate, aspartate, and glutamate) do not inhibit the glucose-6-phosphatase activity and 2) the Ca.alpha-KG and Ca.OAA chelates do not inhibit the glucose-6-phosphatase activity.	Oxalates	207-214	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	382-403
2164694-4	1990	We ascribe this spectrum to the CO2- radical formed from the oxalate ion.	Oxalates	61-68	complement C2	Homo sapiens	32-35
2173703-5	1990	This phenomenon is specific for complexes of Mg2+ with alpha-KG and OAA since 1) the complexes of Mg2+ with a number of other di- or tricarboxylic acids having high structural analogy with alpha-KG and OAA (oxalate, malate, succinate, citrate, aspartate, and glutamate) do not inhibit the glucose-6-phosphatase activity and 2) the Ca.alpha-KG and Ca.OAA chelates do not inhibit the glucose-6-phosphatase activity.	Oxalates	202-205	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	289-310
2173703-5	1990	This phenomenon is specific for complexes of Mg2+ with alpha-KG and OAA since 1) the complexes of Mg2+ with a number of other di- or tricarboxylic acids having high structural analogy with alpha-KG and OAA (oxalate, malate, succinate, citrate, aspartate, and glutamate) do not inhibit the glucose-6-phosphatase activity and 2) the Ca.alpha-KG and Ca.OAA chelates do not inhibit the glucose-6-phosphatase activity.	Oxalates	202-205	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	382-403
2173703-8	1990	The disruption of microsomal integrity by detergents abolishes the effect of Mg.alpha-KG and Mg.OAA, suggesting that the magnesium chelates inhibit the translocase component of the glucose-6-phosphatase system.	Oxalates	96-99	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	181-202
2223823-3	1990	The oxalate formation from glycolate observed with crude enzyme preparations was almost entirely accounted for by the sequential actions of glycolate oxidase and xanthine oxidase (XOD) or lactate dehydrogenase (LDH).	Oxalates	4-11	hydroxyacid oxidase 2	Homo sapiens	140-157
2223823-5	1990	Among the three enzymes known to catalyze the oxidation of glyoxylate to oxalate, glycolate oxidase and XOD showed much lower activities (a higher Km and lower Vmax) toward glyoxylate than those with the respective primary substrates.	Oxalates	73-80	hydroxyacid oxidase 2	Homo sapiens	82-99
2318357-12	1990	Inhibition of transketolase by DCA in vivo was not due to a direct action on the enzyme, however, since DCA, glyoxylate, or oxalate had no appreciable effects on transketolase activity in vitro.	Oxalates	124-131	transketolase	Rattus norvegicus	14-27
2158815-4	1990	When Mn(II) is present in combination with Zn(II), Ni(II), or Co(II), Mn(II) binds predominantly at the site defined by ligands from the protein, oxalate, and the gamma-phosphate of ATP.	Oxalates	146-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
2335959-2	1990	The elevation of the oxalate-synthesizing liver enzyme, glycolate oxidase, produced by feeding glycollic acid was remarkably reduced with the decoction, showing a regulatory action on endogenous oxalate synthesis.	Oxalates	21-28	hydroxyacid oxidase 1	Rattus norvegicus	56-73
2335959-2	1990	The elevation of the oxalate-synthesizing liver enzyme, glycolate oxidase, produced by feeding glycollic acid was remarkably reduced with the decoction, showing a regulatory action on endogenous oxalate synthesis.	Oxalates	195-202	hydroxyacid oxidase 1	Rattus norvegicus	56-73
34952043-14	2022	SIGNIFICANCE: EZH2 inhibition protects against oxalate-induced TECs injury and reduces CaOx crystal deposition in the kidney may by modulating the JNK/FoxO3a pathway; EZH2 may be a promising therapeutic target in TECs injury.	Oxalates	47-54	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	14-18
33945205-1	2022	INTRODUCTION: Primary hyperoxaluria type 1 (PH1) is a rare disease that is challenged by the overproduced oxalate and commonly presented with radiopaque renal stones or obstructive uropathy.	Oxalates	106-113	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	44-47
34659638-9	2021	In addition, knockdown of NCOA4 reversed the effect of oxalate-induced ferroptosis in HK-2 cells.	Oxalates	55-62	nuclear receptor coactivator 4	Homo sapiens	26-31
34952043-11	2022	Furthermore, the MAPK signaling pathway and FoxO3a levels were activated or elevated in TECs exposed to oxalate.	Oxalates	104-111	forkhead box O3	Rattus norvegicus	44-50
34938320-17	2021	Furthermore, treatment with 0.25 and 0.5 mM of oxalate for 48 h significantly upregulated NEAT1, PVT1, CCL7, and ROBO2 expression levels and downregulated hsa-miR-23b-3p, hsa-miR-429, and hsa-miR-139-5p expression levels in the HK-2 cell line in a dose-dependent manner.	Oxalates	47-54	nuclear paraspeckle assembly transcript 1 (non-protein coding)	Mus musculus	90-95
34938320-17	2021	Furthermore, treatment with 0.25 and 0.5 mM of oxalate for 48 h significantly upregulated NEAT1, PVT1, CCL7, and ROBO2 expression levels and downregulated hsa-miR-23b-3p, hsa-miR-429, and hsa-miR-139-5p expression levels in the HK-2 cell line in a dose-dependent manner.	Oxalates	47-54	Pvt1 oncogene	Mus musculus	97-101
34938320-17	2021	Furthermore, treatment with 0.25 and 0.5 mM of oxalate for 48 h significantly upregulated NEAT1, PVT1, CCL7, and ROBO2 expression levels and downregulated hsa-miR-23b-3p, hsa-miR-429, and hsa-miR-139-5p expression levels in the HK-2 cell line in a dose-dependent manner.	Oxalates	47-54	chemokine (C-C motif) ligand 7	Mus musculus	103-107
34938320-17	2021	Furthermore, treatment with 0.25 and 0.5 mM of oxalate for 48 h significantly upregulated NEAT1, PVT1, CCL7, and ROBO2 expression levels and downregulated hsa-miR-23b-3p, hsa-miR-429, and hsa-miR-139-5p expression levels in the HK-2 cell line in a dose-dependent manner.	Oxalates	47-54	roundabout guidance receptor 2	Mus musculus	113-118
34853626-4	2021	In equimolar calcium and oxalate ion concentrations with different buffer solutions, dramatically slower kinetics is observed at pH 6.0 compared to pHs 3.6 and 8.6.	Oxalates	25-32	phenylalanine hydroxylase	Homo sapiens	129-131
34686543-1	2021	INTRODUCTION: Primary hyperoxaluria type 1 (PH1) is an inborn error of glyoxylate metabolism characterized by increased endogenous oxalate production.	Oxalates	131-138	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	44-47
34745086-11	2021	In contrast, oxalate significantly decreased the mRNA levels and secretion of the anti-inflammatory cytokine, Interleukin-10 (IL-10).	Oxalates	13-20	interleukin 10	Homo sapiens	110-124
34745086-11	2021	In contrast, oxalate significantly decreased the mRNA levels and secretion of the anti-inflammatory cytokine, Interleukin-10 (IL-10).	Oxalates	13-20	interleukin 10	Homo sapiens	126-131
34745087-7	2021	Expression of p16 was higher in HK-2 cells treated with H2O2, oxalate, COM, and urine from those with KS than it was in cells treated with urine from those without stones and untreated controls.	Oxalates	62-69	cyclin dependent kinase inhibitor 2A	Homo sapiens	14-17
34745087-10	2021	Transcript expression of shelterin components (TRF1, TRF2 and POT1) was decreased in HK-2 cells treated with H2O2, oxalate, COM, and urine from those with KS, in which case the expression was highest.	Oxalates	115-122	telomeric repeat binding factor 1	Homo sapiens	47-51
34745087-10	2021	Transcript expression of shelterin components (TRF1, TRF2 and POT1) was decreased in HK-2 cells treated with H2O2, oxalate, COM, and urine from those with KS, in which case the expression was highest.	Oxalates	115-122	telomeric repeat binding factor 2	Homo sapiens	53-57
34745087-10	2021	Transcript expression of shelterin components (TRF1, TRF2 and POT1) was decreased in HK-2 cells treated with H2O2, oxalate, COM, and urine from those with KS, in which case the expression was highest.	Oxalates	115-122	protection of telomeres 1	Homo sapiens	62-66
34428444-2	2021	In this study, we attempted to fabricate silica nanomaterials containing copper and silver that were introduced into the MSN matrix, for the first time using oxalate compounds as a metal source.	Oxalates	158-165	moesin	Homo sapiens	121-124
34860265-4	2022	The results of in vitro studies demonstrated that oxalate exposure to renal tubule cells induced TGF-beta1 expression, increasing phospholipid scramblase activity and phosphatidylserine eversion in the renal tubule cell membrane.	Oxalates	50-57	transforming growth factor, beta 1	Rattus norvegicus	97-106
34659638-10	2021	Our results show that the effects of oxalate on the ferroptosis of HK-2 cells are caused by the activation of autophagy, and knockdown of the NCOA4 could ameliorate this effect.	Oxalates	37-44	nuclear receptor coactivator 4	Homo sapiens	142-147
34573096-0	2021	Diminishment of Nrf2 Antioxidative Defense Aggravates Nephrotoxicity of Melamine and Oxalate Coexposure.	Oxalates	85-92	NFE2 like bZIP transcription factor 2	Homo sapiens	16-20
34216092-5	2021	All the available radicals are exploited for selectively converting CO 2 into oxalate that is accompanied by H 2 evolution.	Oxalates	78-85	relaxin 2	Homo sapiens	109-112
34584990-3	2021	The objective of this study was to generate a mouse model deficient in GLO-2 to provide insight into the function of GLO-2 and to determine if it is potentially linked to endogenous oxalate synthesis which could influence urinary oxalate excretion.	Oxalates	182-189	hydroxyacyl glutathione hydrolase	Mus musculus	71-76
34192892-12	2021	A variety of stimuli such as free fatty acids or oxalate crystals induce IL-1alpha surface expression and release by monocytes, which then mediates their adhesion to the endothelium via IL-1 receptor-1.	Oxalates	49-56	interleukin 1 alpha	Mus musculus	73-82
34192892-14	2021	IL-1alpha induces inflammatory injury after experimental AMI and abrogation of IL-1alpha prevents the development of CKD in oxalate or adenine-fed mice.	Oxalates	124-131	interleukin 1 alpha	Mus musculus	0-9
34192892-14	2021	IL-1alpha induces inflammatory injury after experimental AMI and abrogation of IL-1alpha prevents the development of CKD in oxalate or adenine-fed mice.	Oxalates	124-131	interleukin 1 alpha	Mus musculus	79-88
34433051-3	2021	Downregulation and hypermethylation of alanine-glyoxylate aminotransferase (Agxt), which detoxifies glyoxylate, preventing excessive oxalate accumulation, is accompanied by increased oxalate formation after metabolism of the precursor hydroxyproline.	Oxalates	133-140	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	39-74
34246192-8	2021	While oxalate increased oxidized proteins and Snail1 levels, it decreased Nrf2 expression.	Oxalates	6-13	snail family transcriptional repressor 1	Homo sapiens	46-52
34246192-8	2021	While oxalate increased oxidized proteins and Snail1 levels, it decreased Nrf2 expression.	Oxalates	6-13	NFE2 like bZIP transcription factor 2	Homo sapiens	74-78
34246192-10	2021	Finally, silencing of Nrf2 expression by small interfering RNA (siRNA) could abolish such protective effects of caffeine on oxalate-induced EMT.	Oxalates	124-131	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
34433051-3	2021	Downregulation and hypermethylation of alanine-glyoxylate aminotransferase (Agxt), which detoxifies glyoxylate, preventing excessive oxalate accumulation, is accompanied by increased oxalate formation after metabolism of the precursor hydroxyproline.	Oxalates	133-140	alanine-glyoxylate aminotransferase	Mus musculus	76-80
34433051-4	2021	Viral-mediated Agxt transfer or inhibiting hydroxyproline catabolism rescues excessive oxalate release.	Oxalates	87-94	alanine-glyoxylate aminotransferase	Mus musculus	15-19
34490303-10	2021	Conclusion: HRW may alleviate oxalate-induced kidney injury with its anti-oxidative, anti-inflammatory and anti-fibrotic effects via inhibiting PI3K/AKT, NF-kappaB, and TGF-beta pathways.	Oxalates	30-37	thymoma viral proto-oncogene 1	Mus musculus	149-152
34490303-10	2021	Conclusion: HRW may alleviate oxalate-induced kidney injury with its anti-oxidative, anti-inflammatory and anti-fibrotic effects via inhibiting PI3K/AKT, NF-kappaB, and TGF-beta pathways.	Oxalates	30-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	154-163
34490303-10	2021	Conclusion: HRW may alleviate oxalate-induced kidney injury with its anti-oxidative, anti-inflammatory and anti-fibrotic effects via inhibiting PI3K/AKT, NF-kappaB, and TGF-beta pathways.	Oxalates	30-37	transforming growth factor alpha	Mus musculus	169-177
34443596-2	2021	Guided by a high-resolution X-ray structure of FAHD1 liganded by oxalate, the enzymatic mechanism of substrate processing is analyzed in detail.	Oxalates	65-72	fumarylacetoacetate hydrolase domain containing 1	Homo sapiens	47-52
34320345-4	2021	Agxt deletion in apolipoprotein E-deficient (Apoe-/-) mice decreases the glycine/oxalate ratio and increases atherosclerosis with induction of hepatic pro-atherogenic pathways, predominantly cytokine/chemokine signaling and dysregulated redox homeostasis.	Oxalates	81-88	alanine-glyoxylate aminotransferase	Mus musculus	0-4
34320345-4	2021	Agxt deletion in apolipoprotein E-deficient (Apoe-/-) mice decreases the glycine/oxalate ratio and increases atherosclerosis with induction of hepatic pro-atherogenic pathways, predominantly cytokine/chemokine signaling and dysregulated redox homeostasis.	Oxalates	81-88	apolipoprotein E	Mus musculus	45-49
34320345-7	2021	In macrophages, oxalate induces mitochondrial dysfunction and superoxide accumulation, leading to increased CCL5.	Oxalates	16-23	chemokine (C-C motif) ligand 5	Mus musculus	108-112
34320345-8	2021	Conversely, AGXT overexpression in Apoe-/- mice increases the glycine/oxalate ratio and decreases aortic superoxide, CCL5, and atherosclerosis.	Oxalates	70-77	alanine-glyoxylate aminotransferase	Mus musculus	12-16
34320345-8	2021	Conversely, AGXT overexpression in Apoe-/- mice increases the glycine/oxalate ratio and decreases aortic superoxide, CCL5, and atherosclerosis.	Oxalates	70-77	apolipoprotein E	Mus musculus	35-39
34201387-10	2021	Taking all these results together, we conclude that TRPV1 hyperfunction contributes to oxalate-induced renal inflammation.	Oxalates	87-94	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	52-57
34231328-1	2021	BACKGROUND: Animal models have demonstrated an interactive relationship between the epithelial anion exchanger SLC26A6 and transporter NaDC-1 that regulates citrate and oxalate homeostasis.	Oxalates	169-176	solute carrier family 26 member 6	Homo sapiens	111-118
34231328-1	2021	BACKGROUND: Animal models have demonstrated an interactive relationship between the epithelial anion exchanger SLC26A6 and transporter NaDC-1 that regulates citrate and oxalate homeostasis.	Oxalates	169-176	solute carrier family 13 member 2	Homo sapiens	135-141
34201387-4	2021	In TRPV1-expressed proximal tubular cells LLC-PK1, oxalate could induce cell damage in a time- and dose-dependent manner; this was associated with increased arachidonate 12-lipoxygenase (ALOX12) expression and synthesis of endovanilloid 12(S)-hydroxyeicosatetraenoic acid for TRPV1 activation.	Oxalates	51-58	transient receptor potential cation channel subfamily V member 1	Sus scrofa	3-8
35483260-6	2022	Electron paramagnetic resonance (EPR) and quenching experiments demonstrated that oxalate was activated by holes under light to produce  CO2- and enhanced the generation of additional  OH and  O2-, further contributing to the oxidation of As(III) and reduction of Cr(VI).	Oxalates	82-89	complement C2	Homo sapiens	137-140
34201387-4	2021	In TRPV1-expressed proximal tubular cells LLC-PK1, oxalate could induce cell damage in a time- and dose-dependent manner; this was associated with increased arachidonate 12-lipoxygenase (ALOX12) expression and synthesis of endovanilloid 12(S)-hydroxyeicosatetraenoic acid for TRPV1 activation.	Oxalates	51-58	polyunsaturated fatty acid lipoxygenase ALOX15	Sus scrofa	157-185
34201387-4	2021	In TRPV1-expressed proximal tubular cells LLC-PK1, oxalate could induce cell damage in a time- and dose-dependent manner; this was associated with increased arachidonate 12-lipoxygenase (ALOX12) expression and synthesis of endovanilloid 12(S)-hydroxyeicosatetraenoic acid for TRPV1 activation.	Oxalates	51-58	arachidonate 12-lipoxygenase, 12S-type	Sus scrofa	187-193
34201387-4	2021	In TRPV1-expressed proximal tubular cells LLC-PK1, oxalate could induce cell damage in a time- and dose-dependent manner; this was associated with increased arachidonate 12-lipoxygenase (ALOX12) expression and synthesis of endovanilloid 12(S)-hydroxyeicosatetraenoic acid for TRPV1 activation.	Oxalates	51-58	transient receptor potential cation channel subfamily V member 1	Sus scrofa	276-281
34201387-5	2021	Inhibition of ALOX12 or TRPV1 attenuated oxalate-mediated cell damage.	Oxalates	41-48	arachidonate 12-lipoxygenase, 12S-type	Sus scrofa	14-20
34201387-5	2021	Inhibition of ALOX12 or TRPV1 attenuated oxalate-mediated cell damage.	Oxalates	41-48	transient receptor potential cation channel subfamily V member 1	Sus scrofa	24-29
34267881-1	2021	Both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA) influence the endogenous synthesis of oxalate and are clinically validated targets for treatment of primary hyperoxaluria (PH).	Oxalates	101-108	lactate dehydrogenase A	Mus musculus	32-55
34267881-1	2021	Both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA) influence the endogenous synthesis of oxalate and are clinically validated targets for treatment of primary hyperoxaluria (PH).	Oxalates	101-108	lactate dehydrogenase A	Mus musculus	57-61
34267881-5	2021	Dual inhibitor 7 demonstrated an IC50 of 88 nM for oxalate reduction in an Agxt-knockdown mouse hepatocyte assay.	Oxalates	51-58	alanine-glyoxylate aminotransferase	Mus musculus	75-79
35500753-3	2022	It has been known that oxalate or bicarbonate transporter SLC26A6 is involved in oxalate homeostasis and its deletion results in kidney stone formation and addressed that patients with kidney stones possess higher cancer risk.	Oxalates	81-88	solute carrier family 26 member 6	Homo sapiens	58-65
35500753-6	2022	The beta-estradiol stimulation attenuated oxalate or bicarbonate transporting activities through SLC26A6.	Oxalates	42-49	solute carrier family 26 member 6	Homo sapiens	97-104
35237473-1	2022	Primary hyperoxaluria type 1 (PH1) is a rare genetic disease that results in oxalate overproduction leading to nephrolithiasis (NL), nephrocalcinosis (NC), kidney failure, and systemic oxalosis.	Oxalates	77-84	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
35129638-9	2022	Synbiotic supplementation had a beneficial effect on the total oxalate-degrading activity of gut microbiota, which resulted in decreased UOx excretion in rats.	Oxalates	63-70	urate oxidase	Rattus norvegicus	137-140
35608921-4	2022	SLC26A3 (originally named DRA, down-regulated in adenoma) is an anion exchanger of chloride, bicarbonate and oxalate thought to facilitate intestinal oxalate absorption, as evidenced by ~70% reduced urine oxalate excretion in knock-out mice.	Oxalates	109-116	solute carrier family 26, member 3	Mus musculus	0-7
35608921-4	2022	SLC26A3 (originally named DRA, down-regulated in adenoma) is an anion exchanger of chloride, bicarbonate and oxalate thought to facilitate intestinal oxalate absorption, as evidenced by ~70% reduced urine oxalate excretion in knock-out mice.	Oxalates	109-116	solute carrier family 26, member 3	Mus musculus	26-29
35608921-4	2022	SLC26A3 (originally named DRA, down-regulated in adenoma) is an anion exchanger of chloride, bicarbonate and oxalate thought to facilitate intestinal oxalate absorption, as evidenced by ~70% reduced urine oxalate excretion in knock-out mice.	Oxalates	150-157	solute carrier family 26, member 3	Mus musculus	0-7
35608921-4	2022	SLC26A3 (originally named DRA, down-regulated in adenoma) is an anion exchanger of chloride, bicarbonate and oxalate thought to facilitate intestinal oxalate absorption, as evidenced by ~70% reduced urine oxalate excretion in knock-out mice.	Oxalates	150-157	solute carrier family 26, member 3	Mus musculus	26-29
35608921-4	2022	SLC26A3 (originally named DRA, down-regulated in adenoma) is an anion exchanger of chloride, bicarbonate and oxalate thought to facilitate intestinal oxalate absorption, as evidenced by ~70% reduced urine oxalate excretion in knock-out mice.	Oxalates	205-212	solute carrier family 26, member 3	Mus musculus	0-7
35608921-4	2022	SLC26A3 (originally named DRA, down-regulated in adenoma) is an anion exchanger of chloride, bicarbonate and oxalate thought to facilitate intestinal oxalate absorption, as evidenced by ~70% reduced urine oxalate excretion in knock-out mice.	Oxalates	205-212	solute carrier family 26, member 3	Mus musculus	26-29
35608921-5	2022	We previously identified, by high-throughput screening and medicinal chemistry, a small molecule SLC26A3 inhibitor (DRAinh-A270) that selectively inhibited SLC26A3-mediated chloride/bicarbonate exchange (IC50 ~ 35 nM), and, as found here, oxalate/chloride exchange (IC50 ~ 60 nM).	Oxalates	239-246	solute carrier family 26, member 3	Mus musculus	97-104
35608921-5	2022	We previously identified, by high-throughput screening and medicinal chemistry, a small molecule SLC26A3 inhibitor (DRAinh-A270) that selectively inhibited SLC26A3-mediated chloride/bicarbonate exchange (IC50 ~ 35 nM), and, as found here, oxalate/chloride exchange (IC50 ~ 60 nM).	Oxalates	239-246	solute carrier family 26, member 3	Mus musculus	156-163
35152567-0	2022	Oxalate Pushes Efficiency of CsPb0.7 Sn0.3 IBr2 Based All-Inorganic Perovskite Solar Cells to over 14.	Oxalates	0-7	granzyme B	Homo sapiens	29-33
35251369-4	2022	The role of transient receptor potential cation channel subfamily V member 5 (TRPV5) in oxalate-induced cells was studied by TRPV5 overexpression transfection, qRT-PCR, Western blot, MTT, and crystal adhesion detection.	Oxalates	88-95	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	12-76
35251369-4	2022	The role of transient receptor potential cation channel subfamily V member 5 (TRPV5) in oxalate-induced cells was studied by TRPV5 overexpression transfection, qRT-PCR, Western blot, MTT, and crystal adhesion detection.	Oxalates	88-95	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	78-83
35251369-6	2022	The validation of UMOD-regulating TRPV5 in viability, crystal adhesion, and Ca2+ concentration of oxalate-induced cells was performed.	Oxalates	98-105	uromodulin	Rattus norvegicus	18-22
35251369-6	2022	The validation of UMOD-regulating TRPV5 in viability, crystal adhesion, and Ca2+ concentration of oxalate-induced cells was performed.	Oxalates	98-105	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	34-39
35592622-1	2022	Primary hyperoxaluria type 1 (PH1) is an autosomal recessive inborn error of metabolism characterized by marked hepatic overproduction of oxalate due to deficiency of hepatic peroxisomal alanine-glyoxylate aminotransferase caused by AGXT gene mutation.	Oxalates	138-145	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	0-28
35592622-1	2022	Primary hyperoxaluria type 1 (PH1) is an autosomal recessive inborn error of metabolism characterized by marked hepatic overproduction of oxalate due to deficiency of hepatic peroxisomal alanine-glyoxylate aminotransferase caused by AGXT gene mutation.	Oxalates	138-145	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
35592622-1	2022	Primary hyperoxaluria type 1 (PH1) is an autosomal recessive inborn error of metabolism characterized by marked hepatic overproduction of oxalate due to deficiency of hepatic peroxisomal alanine-glyoxylate aminotransferase caused by AGXT gene mutation.	Oxalates	138-145	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	167-222
35592622-1	2022	Primary hyperoxaluria type 1 (PH1) is an autosomal recessive inborn error of metabolism characterized by marked hepatic overproduction of oxalate due to deficiency of hepatic peroxisomal alanine-glyoxylate aminotransferase caused by AGXT gene mutation.	Oxalates	138-145	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	233-237
35627178-12	2022	Cats with the GG variant of the AGXT2 SNP required more added oxalate to initiate urine crystal formation after consuming test food compared with control food, indicating a decreased risk of oxalate crystal formation in GG cats.	Oxalates	62-69	alanine--glyoxylate aminotransferase 2	Felis catus	32-37
35128564-9	2022	Oxalate also decreased the protein expression level of Nox4 and increased the protein expression level of p22.	Oxalates	0-7	NADPH oxidase 4	Rattus norvegicus	55-59
35128564-11	2022	In addition, Nox2 inhibitor or mtROS scavenging prevented oxalate-induced cell injury, reversed by an inhibitor of Nox4/1.	Oxalates	58-65	cytochrome b-245 beta chain	Rattus norvegicus	13-17
35128564-11	2022	In addition, Nox2 inhibitor or mtROS scavenging prevented oxalate-induced cell injury, reversed by an inhibitor of Nox4/1.	Oxalates	58-65	NADPH oxidase 4	Rattus norvegicus	115-119
35266883-1	2022	PURPOSE OF REVIEW: Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder that causes hepatic overproduction of oxalate and, often, nephrocalcinosis, nephrolithiasis, chronic kidney disease, and kidney failure.	Oxalates	119-126	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	49-52
35266883-7	2022	SUMMARY: Novel treatments can reduce the plasma oxalate concentration and urinary oxalate excretion in PH1 patients.	Oxalates	48-55	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	103-106
35251369-10	2022	Upregulation of TRPV5 protected NRK-52E cells from oxalate-induced injury by enhancing cell viability and inhibiting CaOx adhesion.	Oxalates	51-58	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	16-21
35251369-11	2022	UMOD was depleted in oxalate-induced cells and positively interacted with TRPV5.	Oxalates	21-28	uromodulin	Rattus norvegicus	0-4
35251369-13	2022	miR-103a-3p targeted UMOD and was mediated in the regulation of the UMOD/TRPV5 axis in oxalate-induced cells.	Oxalates	87-94	uromodulin	Rattus norvegicus	21-25
35251369-13	2022	miR-103a-3p targeted UMOD and was mediated in the regulation of the UMOD/TRPV5 axis in oxalate-induced cells.	Oxalates	87-94	uromodulin	Rattus norvegicus	68-72
35251369-13	2022	miR-103a-3p targeted UMOD and was mediated in the regulation of the UMOD/TRPV5 axis in oxalate-induced cells.	Oxalates	87-94	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	73-78
35163480-1	2022	We report a new structure of {(Co(bpy)2(ox))({Cu2(bpy)2(ox)}Fe(ox)3)}n 8.5nH2O NCU-1 presenting a rare ladder topology among oxalate-based coordination polymers with anionic chains composed of alternately arranged (Cu2(bpy)2(ox))2+ and (Fe(ox)3)3- moieties.	Oxalates	125-132	immunoglobulin kappa variable 1-35	Mus musculus	46-55
35163480-1	2022	We report a new structure of {(Co(bpy)2(ox))({Cu2(bpy)2(ox)}Fe(ox)3)}n 8.5nH2O NCU-1 presenting a rare ladder topology among oxalate-based coordination polymers with anionic chains composed of alternately arranged (Cu2(bpy)2(ox))2+ and (Fe(ox)3)3- moieties.	Oxalates	125-132	immunoglobulin kappa variable 1-35	Mus musculus	215-224
35257062-1	2022	Introduction: Primary hyperoxaluria type 1 (PH1) is a rare genetic disease caused by hepatic overproduction of oxalate, leading to kidney stones, nephrocalcinosis, kidney failure, and systemic oxalosis.	Oxalates	111-118	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	44-47
35072516-9	2022	The WS constituent, oxalate, increased MUC5AC levels similar to the whole WS extract, especially in primary human AECs homozygous for p53 arginine, and in mice with a modified Tp53 gene.	Oxalates	20-27	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	39-45
35072516-10	2022	Further, the anion exchange protein, SLC26A9, when reduced, enhanced WS- and oxalate-induced mucin expression.	Oxalates	77-84	solute carrier family 26 member 9	Homo sapiens	37-44
35072516-10	2022	Further, the anion exchange protein, SLC26A9, when reduced, enhanced WS- and oxalate-induced mucin expression.	Oxalates	77-84	LOC100508689	Homo sapiens	93-98
35071135-1	2021	Background: Primary hyperoxaluria type 1 (PH1) is a rare genetic disease caused by hepatic overproduction of oxalate, ultimately responsible for kidney stones, kidney failure and systemic oxalosis.	Oxalates	109-116	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	42-45
35071135-3	2021	It has been shown to reduce hepatic oxalate production by targeting glycolate oxidase, and to dramatically reduce oxalate excretion.	Oxalates	36-43	hydroxyacid oxidase 2	Homo sapiens	68-85
2538460-6	1989	When 13C-labeled oxalate was used as the synergistic anion, 13C-ESEEM was observed for both the copper and vanadyl complexes of lactoferrin and transferrin.	Oxalates	17-24	transferrin	Homo sapiens	144-155
2570167-5	1989	There was a highly significant positive correlation between urinary oxalate and N-acetyl-beta-glucosaminidase.	Oxalates	68-75	O-GlcNAcase	Rattus norvegicus	80-109
35155860-1	2022	Introduction: In primary hyperoxaluria type 1 (PH1), oxalate overproduction frequently causes kidney stones, nephrocalcinosis, and kidney failure.	Oxalates	53-60	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	47-50
2632051-7	1989	Also, regucalcin (2.0 microM)-induced retardation of 45Ca2+ uptake was completely blocked by the presence of a Ca2(+)-trapping agent, oxalate (3 mM).	Oxalates	134-141	regucalcin	Rattus norvegicus	6-16
2632051-13	1989	The presence of oxalate (3 mM) completely blocked the effect of regucalcin on 45Ca2+ release from the microsomes.	Oxalates	16-23	regucalcin	Rattus norvegicus	64-74
2562274-7	1989	In summary, the data reveal that caffeine (1) inhibits oxalate entry pathway via inhibition of CaM, and (2) directly modifies CaM-dependent component of Ca2+ fluxes in the SR and reduces steady-state Ca2+ accumulation due to increased Ca2+ release through a Ca2+ efflux pathway which is inhibited by CaM but not due to reduced catalytic activity of the pump; and that the masseter muscle SR vesicles include IP3-sensitive Ca2+ release channel.	Oxalates	55-62	calmodulin-2	Canis lupus familiaris	95-98
2538460-7	1989	The deeper 13C modulation for copper and vanadyl transferrin [13C]oxalate than for vanadyl transferrin [13C]carbonate suggests that both ends of the oxalate are bound to the metal in the transferrin and lactoferrin complexes.	Oxalates	66-73	transferrin	Homo sapiens	49-60
2444772-8	1987	The Na+-dependent Ca2+ uptake in SL and the oxalate-supported Ca2+ uptake in SR were also stimulated by insulin; the maximum increase in Ca2+ accumulation in these vesicles was approximately 150 and 25%, respectively.	Oxalates	44-51	insulin	Homo sapiens	104-111
2844093-2	1988	A preincubation with xanthine oxidase plus xanthine at 37 degrees C preferentially inactivated the oxalate-stimulated Ca2+ uptake by the F3 fraction rather than the phosphate-stimulated uptake by the F2 fraction, indicating that the Ca2+ pump in the ER was more susceptible to this free radical.	Oxalates	99-106	xanthine dehydrogenase	Sus scrofa	21-37
2822172-2	1987	Oxalate is a potent in vitro inhibitor of red cell lactate dehydrogenase, monophosphoglycerate mutase, and pyruvate kinase (PK).	Oxalates	0-7	pyruvate kinase PKLR	Oryctolagus cuniculus	107-122
2822172-2	1987	Oxalate is a potent in vitro inhibitor of red cell lactate dehydrogenase, monophosphoglycerate mutase, and pyruvate kinase (PK).	Oxalates	0-7	pyruvate kinase PKLR	Oryctolagus cuniculus	124-126
2822172-4	1987	Determination of the levels of intermediate compounds in red cells incubated with oxalate suggest the presence of inhibition at the PK step, indicating that this is the site of oxalate action.	Oxalates	82-89	pyruvate kinase PKLR	Oryctolagus cuniculus	132-134
2822172-4	1987	Determination of the levels of intermediate compounds in red cells incubated with oxalate suggest the presence of inhibition at the PK step, indicating that this is the site of oxalate action.	Oxalates	177-184	pyruvate kinase PKLR	Oryctolagus cuniculus	132-134
3390916-1	1988	In this simple, sensitive, and rapid enzymatic method for the determination of oxalate in urine or plasma, oxalate oxidase (EC 1.2.3.4) prepared from barley seedlings is used to convert oxalate to carbon dioxide and hydrogen peroxide, which is determined photometrically at 600 nm, with use of horseradish peroxidase, by oxidative coupling of 3-methyl-2-benzothiazoline hydrazine with N,N-dimethylaniline.	Oxalates	79-86	LOC548260	Hordeum vulgare	107-122
2969420-2	1988	Oxidation products of linoleic and arachidonic acids, obtained either by autoxidation or incubation with soybean lipoxygenase, effectively blocked in a dose-dependent manner, the net influx of calcium in the absence or presence of 5 mM of oxalate.	Oxalates	239-246	linoleate 9S-lipoxygenase-4	Glycine max	113-125
3662529-4	1987	On the other hand, Ca2+ uptake in the presence of oxalate by saponin-treated lymphocytes was stimulated by GTP and this stimulation was abolished when polyethylene glycol was concomitantly present.	Oxalates	50-57	carbonic anhydrase 2	Homo sapiens	19-22
2945712-3	1986	The amount of transported Ca2+ increased four times in the presence of 20 mM oxalate owing to the precipitation of calcium oxalate, which was detected inside the microsomal vesicles by electron microscopy.	Oxalates	77-84	carbonic anhydrase 2	Homo sapiens	26-29
3652453-2	1987	In agreement with earlier reports we found that alanine glyoxylate aminotransferase was strongly deficient in liver from a hyperoxaluria type I patient, thus explaining the increased urinary excretion of oxalate and glycollate in these patients.	Oxalates	204-211	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	48-83
3306417-4	1987	In the patients with renal failure unrelated to primary hyperoxaluria, oxalate retention increases rapidly when the glomerular filtration rate (GFR) decreases below about 20 ml X min-1.	Oxalates	71-78	CD59 molecule (CD59 blood group)	Homo sapiens	179-184
3777808-5	1986	Addition of oxalate (5 mM) in Tris buffer abolishes the interference of lactate dehydrogenase (LDH).	Oxalates	12-19	LDH	Bos taurus	72-93
2935532-3	1986	The reconstituted vesicles exhibited ATP-dependent oxalate-facilitated Ca2+ accumulation with rates and efficiency comparable to the best reconstituted skeletal muscle preparation (Ca2+-loading rate = 1.65 +/- 0.31 mumol mg-1 min-1, Ca2+-activated ATPase activity = 2.39 +/- 0.25 mumol mg-1 min-1, efficiency (Ca2+/ATP) = 0.69 +/- 0.09).	Oxalates	51-58	CD59 molecule (CD59 blood group)	Homo sapiens	226-231
2935532-3	1986	The reconstituted vesicles exhibited ATP-dependent oxalate-facilitated Ca2+ accumulation with rates and efficiency comparable to the best reconstituted skeletal muscle preparation (Ca2+-loading rate = 1.65 +/- 0.31 mumol mg-1 min-1, Ca2+-activated ATPase activity = 2.39 +/- 0.25 mumol mg-1 min-1, efficiency (Ca2+/ATP) = 0.69 +/- 0.09).	Oxalates	51-58	CD59 molecule (CD59 blood group)	Homo sapiens	291-296
3945245-3	1986	Oxalate exchange was significantly higher in the 98 patients with idiopathic stone formation than in the controls (-1.10 +/- 0.95 [SD] X 10(-2) min-1 vs. -0.31 +/- 0.12 X 10(-2); P less than 0.001); it was above the upper limits of normal in 78 of these patients.	Oxalates	0-7	CD59 molecule (CD59 blood group)	Homo sapiens	144-149
3777808-5	1986	Addition of oxalate (5 mM) in Tris buffer abolishes the interference of lactate dehydrogenase (LDH).	Oxalates	12-19	LDH	Bos taurus	95-98
2996495-1	1985	A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol.	Oxalates	92-99	ketohexokinase	Homo sapiens	11-25
2412614-2	1985	It was found that under the effect of caffeine (5 mM) the rate of Ca2 transport in the presence of oxalate decreased by 30 to 40%.	Oxalates	99-106	carbonic anhydrase 2	Rattus norvegicus	66-69
3959064-5	1986	Oxalate affected Ca2+ permeability of both antrum and fundus microsome vesicles similarly.	Oxalates	0-7	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	17-20
2952866-4	1986	MgATP induces minor additional binding of PCB- in the presence of oxalate and it is followed by release of the lipophilic anion from the vesicles.	Oxalates	66-73	pyruvate carboxylase	Homo sapiens	42-45
2996495-5	1985	With D-xylulose as substrate, ketohexokinase and aldolase can catalyse a reaction sequence which forms glycolaldehyde, a known precursor of oxalate.	Oxalates	140-147	ketohexokinase	Homo sapiens	30-44
6499469-1	1984	Ethylene glycol, a major constituent of antifreeze, is metabolized by alcohol dehydrogenase to glycoaldehyde, glycolate, glyoxylate, and oxalate.	Oxalates	137-144	aldo-keto reductase family 1 member A1	Homo sapiens	70-91
4003387-4	1985	Higher levels of Zn+2 (greater than 0.2 mM final concentration) were required to accelerate thrombin-induced clot formation in the presence of citrate or oxalate.	Oxalates	154-161	coagulation factor II, thrombin	Homo sapiens	92-100
2981853-2	1985	ATP-dependent Ca2+ uptake was stimulated by oxalate and phosphate to steady-state levels of greater than 100 nmol/mg protein, and the accumulated Ca2+ could be largely released by ionophore A23187.	Oxalates	44-51	carbonic anhydrase 2	Homo sapiens	14-17
3009653-0	1985	The metabolic production of oxalate from xylitol: activities of transketolase, transaldolase, fructokinase and aldolase in liver, kidney, brain, heart and muscle in the rat, mouse, guinea pig, rabbit and human.	Oxalates	28-35	transketolase	Rattus norvegicus	64-77
3009653-0	1985	The metabolic production of oxalate from xylitol: activities of transketolase, transaldolase, fructokinase and aldolase in liver, kidney, brain, heart and muscle in the rat, mouse, guinea pig, rabbit and human.	Oxalates	28-35	transaldolase 1	Rattus norvegicus	79-92
3982578-2	1985	Combined calcium and oxalate restriction significantly decreased PSF only in NC and DH whereas the decrease was not significant in IH because of a concomitant significant increase in oxalate excretion.	Oxalates	21-28	insulin like growth factor binding protein 7	Homo sapiens	65-68
3982578-3	1985	Increase of PSF with the oxalate load was significantly greater during a calcium-restricted diet than during the 1.5-gram calcium diet in all groups of patients (4, 6 and 12 times greater in NC, DH and IH, respectively).	Oxalates	25-32	insulin like growth factor binding protein 7	Homo sapiens	12-15
3982578-4	1985	These data show the critical role of oxalate restriction when calcium is restricted in order to decrease the PSF.	Oxalates	37-44	insulin like growth factor binding protein 7	Homo sapiens	109-112
6094249-1	1984	The decay rate of the excited triplet state of Zn cytochrome c was enhanced by electron acceptors including methyl viologen and ferric complexes of cyanide, oxalate, EDTA and cytochrome c at room temperature.	Oxalates	157-164	cytochrome c, somatic	Homo sapiens	50-62
6713285-3	1984	However, the fractions F2 and F3 differ from each other in that: (a) F3 shows higher permeability to Ca2+, and (b) F3 shows higher stimulation of the ATP-dependent Ca2+ uptake by oxalate.	Oxalates	179-186	carbonic anhydrase 2	Rattus norvegicus	164-167
6333869-3	1984	In the presence of 10 mM-NaN3, the Ca2+ accumulated in the presence of oxalate was seen in the endoplasmic reticulum of saponin-treated macrophages by electron microscopy, indicating that the site of Ca2+ released by inositol 1,4,5-trisphosphate may be endoplasmic reticulum-like membranes.	Oxalates	71-78	carbonic anhydrase 2	Homo sapiens	35-38
6333869-3	1984	In the presence of 10 mM-NaN3, the Ca2+ accumulated in the presence of oxalate was seen in the endoplasmic reticulum of saponin-treated macrophages by electron microscopy, indicating that the site of Ca2+ released by inositol 1,4,5-trisphosphate may be endoplasmic reticulum-like membranes.	Oxalates	71-78	carbonic anhydrase 2	Homo sapiens	200-203
6703688-10	1984	Urinary excretion of oxalate began to increase in 8-9 days, when AGT 2 remained intact but most of AGT 1 is depleted.	Oxalates	21-28	alanine-glyoxylate aminotransferase 2	Rattus norvegicus	65-70
6703688-10	1984	Urinary excretion of oxalate began to increase in 8-9 days, when AGT 2 remained intact but most of AGT 1 is depleted.	Oxalates	21-28	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	65-68
6721623-5	1984	Thus clearly the oxalate-stimulated and the oxalate-independent Ca-uptake in rat vas deferens smooth muscle microsomes show several differences but it is unknown whether the differences are due to the existence of two distinct Ca-pump proteins or due to different microenvironment of the same protein resulting from membrane heterogeneity.	Oxalates	17-24	arginine vasopressin	Rattus norvegicus	81-84
6721623-5	1984	Thus clearly the oxalate-stimulated and the oxalate-independent Ca-uptake in rat vas deferens smooth muscle microsomes show several differences but it is unknown whether the differences are due to the existence of two distinct Ca-pump proteins or due to different microenvironment of the same protein resulting from membrane heterogeneity.	Oxalates	44-51	arginine vasopressin	Rattus norvegicus	81-84
6135447-3	1983	Membrane vesicles that were exposed to oxalate as a calcium-trapping agent accumulated Ca2+ in the presence of Mg2+ and ATP.	Oxalates	39-46	carbonic anhydrase 2	Homo sapiens	87-90
6630519-3	1983	To investigate the mechanism of its cholesterol-lowering action, we studied the effects of DCA and its hepatic metabolites, glyoxylate and oxalate, on the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase) obtained from livers of healthy, reverse light-cycled rats.	Oxalates	139-146	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	167-233
6615890-2	1983	Addition of varying concentrations of oxalate to isolated chicken hepatocytes reduced gluconeogenesis from lactate in a manner indicating that pyruvate carboxylase was not the rate-limiting step.	Oxalates	38-45	pyruvate carboxylase	Gallus gallus	143-163
6615892-2	1983	All the metabolic modifications observed are explained by pyruvate carboxylase inhibition, since oxalate hardly modifies the flux through pyruvate dehydrogenase.	Oxalates	97-104	pyruvate carboxylase	Rattus norvegicus	58-78
6357283-3	1983	A model is proposed in which glycolate oxidase in the peroxisomes and lactate dehydrogenase in the cytosol cooperate in the production of oxalate.	Oxalates	138-145	hydroxyacid oxidase 1	Rattus norvegicus	29-46
6657662-3	1983	Increase of PSF with the oxalate load was significantly greater on calcium restricted than on calcium unrestricted diets in all groups of patients (4-6-12 times greater in NCa, DH and IH respectively).	Oxalates	25-32	insulin like growth factor binding protein 7	Homo sapiens	12-15
6882465-3	1983	The effects of dichloroacetate depend on experimental conditions and the intensity of its catabolization into oxalate: the resultant action of dichloroacetate on tested parameters combines the effects of pyruvate dehydrogenase activation on the one hand, and pyruvate carboxylase inhibition by oxalate on the other.	Oxalates	110-117	pyruvate carboxylase	Rattus norvegicus	259-279
16662946-4	1983	A model is proposed in which glycolate oxidase in the peroxisomes and lactate dehydrogenase in the cytosol are involved in the production of oxalate.	Oxalates	141-148	hydroxyacid oxidase 2	Homo sapiens	29-46
6349516-5	1983	It is concluded that glycolate-induced oxalate biosynthesis in rats involves increased activity of liver glycolate oxidase, and pyruvate feeding inhibits glycolate oxidase, thereby decreasing oxalate biosynthesis.	Oxalates	39-46	hydroxyacid oxidase 1	Rattus norvegicus	105-122
6657662-4	1983	This shows the critical role of oxalate restriction when calcium is restricted in order to decrease the PSF.	Oxalates	32-39	insulin like growth factor binding protein 7	Homo sapiens	104-107
6284103-3	1982	It is concluded that metabolic pathways based on a combination of the transketolase, fructokinase and aldolase reactions can account for the production of glucose, lactate, tetronates (C-threonic and D-erythronic acids) and oxalate (precursors) during the metabolism of xylitol administered parenterally.	Oxalates	224-231	transketolase	Homo sapiens	70-83
6284103-1	1982	It has been proposed previously that oxalate precursors may be formed in the transketolase reaction during the metabolism of xylitol.	Oxalates	37-44	transketolase	Homo sapiens	77-90
6284103-3	1982	It is concluded that metabolic pathways based on a combination of the transketolase, fructokinase and aldolase reactions can account for the production of glucose, lactate, tetronates (C-threonic and D-erythronic acids) and oxalate (precursors) during the metabolism of xylitol administered parenterally.	Oxalates	224-231	ketohexokinase	Homo sapiens	85-97
6284103-2	1982	It is shown in this paper that fructokinase and aldolase, purified from human liver, provide an alternative model in that, in coupled sequence, they produce glycolaldehyde, an oxalate precursor, from D-xylulose via D-xylulose 1-phosphate; D-fructose does not give rise to glycolaldehyde.	Oxalates	176-183	ketohexokinase	Homo sapiens	31-43
7241575-2	1981	Cleavage of 55% of the lecithin in intact human erythrocytes by phospholipase A2 (bee venom) markedly inhibits the mediated transport of L-lactate (via the monocarboxylate carrier) and of L-arabinose (via the monosaccharide carrier), while the major anion exchange system (probed by oxalate) and diffusion via the lipid domain (probed by erythritol) remain essentially unaltered.	Oxalates	283-290	phospholipase A2 group IB	Homo sapiens	64-80
6455156-2	1981	Calmodulin enhanced 2.5-fold 45Ca accumulation by EGTA-treated microsomes incubated with 10 microM Ca2+ (in the absence of oxalate) by increasing markedly the apparent affinity of the transport system for Ca2+.	Oxalates	123-130	calmodulin 1	Rattus norvegicus	0-10
6258679-2	1980	The preparation was capable of an oxalate-stimulated Ca2+ uptake at a mean rate of 0.74 nmol Ca2+ mg-1 protein min-1 which could be inhibited by a Ca2+ ionophore, A 23 187, and by Tween 80.	Oxalates	34-41	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	98-102
6258679-2	1980	The preparation was capable of an oxalate-stimulated Ca2+ uptake at a mean rate of 0.74 nmol Ca2+ mg-1 protein min-1 which could be inhibited by a Ca2+ ionophore, A 23 187, and by Tween 80.	Oxalates	34-41	CD59 molecule (CD59 blood group)	Homo sapiens	111-116
6451219-4	1980	In these vesicles calmodulin increases the Ca2+ uptake after 20 min in an oxalate-free medium and the (Ca2+ + Mg2+)-dependent ATPase respectively by a factor of 3.82 and 6.18.	Oxalates	74-81	calmodulin 1	Homo sapiens	18-28
6778509-2	1980	Oxalate apparently acts by inhibiting pyruvate carboxylase (EC 6.4.1.1.).	Oxalates	0-7	pyruvate carboxylase	Rattus norvegicus	38-58
11826-17	1976	The relative binding of iron by ovotranferrin and human transferrin was affected little when bicarbonate anion was replaced by oxalate, although the ratio of the two binding constants for ovotranferrin increased.	Oxalates	127-134	transferrin	Homo sapiens	56-67
7408199-1	1980	A new colorimetric, enzymic method for determination of serum oxalate is described using oxalate oxidase from barley seedlings.	Oxalates	62-69	LOC548260	Hordeum vulgare	89-104
7239632-3	1980	In some components of the Krebs cycle and in dilute hydrochloric and in oxalic acids, the reaction is limited by the exchange of Mg2+ in the first mineral layer.	Oxalates	72-84	mucin 7, secreted	Homo sapiens	129-132
149789-8	1978	The Ca2+, mg2+-ATPase with oxalate, so-called "extra ATPase," showed the same response to the ions as did the activity without oxalate during storage.	Oxalates	27-34	dynein axonemal heavy chain 8	Homo sapiens	15-21
149789-8	1978	The Ca2+, mg2+-ATPase with oxalate, so-called "extra ATPase," showed the same response to the ions as did the activity without oxalate during storage.	Oxalates	27-34	dynein axonemal heavy chain 8	Homo sapiens	53-59
149789-8	1978	The Ca2+, mg2+-ATPase with oxalate, so-called "extra ATPase," showed the same response to the ions as did the activity without oxalate during storage.	Oxalates	127-134	dynein axonemal heavy chain 8	Homo sapiens	15-21
149789-8	1978	The Ca2+, mg2+-ATPase with oxalate, so-called "extra ATPase," showed the same response to the ions as did the activity without oxalate during storage.	Oxalates	127-134	dynein axonemal heavy chain 8	Homo sapiens	53-59
999893-8	1976	In all cases except ovotranferrin, sheep serum transferrin, and human transferrin with oxalate as the anion, changes in Stokes" radius for the addition of the first and second iron atoms are similar.	Oxalates	87-94	transferrin	Homo sapiens	70-81
999893-12	1976	Human transferrin with oxalate as the anion shows a greater change for the first atom bound than for the second which is consistent with the increased size of the oxalate ion compared with bicarbonate.	Oxalates	23-30	transferrin	Homo sapiens	6-17
999893-12	1976	Human transferrin with oxalate as the anion shows a greater change for the first atom bound than for the second which is consistent with the increased size of the oxalate ion compared with bicarbonate.	Oxalates	163-170	transferrin	Homo sapiens	6-17
6449236-2	1980	In isolated hepatocytes, dichloroacetate directly activates pyruvate dehydrogenase whereas its biotransformation product, oxalate, inhibits pyruvate carboxylase and pyruvate kinase.	Oxalates	122-129	pyruvate carboxylase	Homo sapiens	140-160
464357-8	1979	The 72-hour concentration after exposure to methoxyflurane was 2.5 times the preanesthetic (mg/mOsm) oxalate concentration.	Oxalates	101-108	oncostatin M	Mus musculus	95-99
22546-0	1978	Oxalate and spin-labeled oxalate as probes of the anion binding site of human transferrin.	Oxalates	0-7	transferrin	Homo sapiens	78-89
22546-0	1978	Oxalate and spin-labeled oxalate as probes of the anion binding site of human transferrin.	Oxalates	25-32	spindlin 1	Homo sapiens	12-16
22546-0	1978	Oxalate and spin-labeled oxalate as probes of the anion binding site of human transferrin.	Oxalates	25-32	transferrin	Homo sapiens	78-89
162560-1	1976	Ca++-uptake and Mg++-Ca++-dependent ATPase activity of skeletal muscle sarcoplasmic reticulum vesicles were reciprocally affected by increasing the oxalate concentration from 0 to 4 mM.	Oxalates	148-155	dynein axonemal heavy chain 8	Homo sapiens	36-42
162560-5	1976	The kinetics of Ca++-uptake and ATPase activity were also differentially affected by oxalate.	Oxalates	85-92	dynein axonemal heavy chain 8	Homo sapiens	32-38
1083207-1	1975	Oxalate is metabolized by the glycerate pathway involving glyoxylate carboligase in Alcaligenes LOx and Pseudomonas KOx, and by the serine pathway involving hydroxypyruvate reductase in Ps.MOx and Ps.AM1 (var.	Oxalates	0-7	lysyl oxidase	Homo sapiens	96-99
1066329-1	1976	Oxalate metabolism was assessed in normal rats and rats deficient in vitamins B-1 and B-6 during intravenous infusions of solutions containing glucose, fructose, sorbitol or xylitol.	Oxalates	0-7	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	78-89
1083207-1	1975	Oxalate is metabolized by the glycerate pathway involving glyoxylate carboligase in Alcaligenes LOx and Pseudomonas KOx, and by the serine pathway involving hydroxypyruvate reductase in Ps.MOx and Ps.AM1 (var.	Oxalates	0-7	NADPH oxidase 4	Homo sapiens	116-119
1083207-1	1975	Oxalate is metabolized by the glycerate pathway involving glyoxylate carboligase in Alcaligenes LOx and Pseudomonas KOx, and by the serine pathway involving hydroxypyruvate reductase in Ps.MOx and Ps.AM1 (var.	Oxalates	0-7	monooxygenase DBH like 1	Homo sapiens	189-192
1083207-4	1975	A.LOx possesses two different mechanisms for the oxidation of formate: (1) the constitutive formate oxidase which is present in the particulate fraction of oxalate-grown and succinate-plus-formate-grown cells; (2) the inducible NAD-linked formate dehydrogenase present in the 100 000 x g supernatant fraction of the cell-free extracts of oxalate-grown cells alone.	Oxalates	156-163	lysyl oxidase	Homo sapiens	2-5
1083207-4	1975	A.LOx possesses two different mechanisms for the oxidation of formate: (1) the constitutive formate oxidase which is present in the particulate fraction of oxalate-grown and succinate-plus-formate-grown cells; (2) the inducible NAD-linked formate dehydrogenase present in the 100 000 x g supernatant fraction of the cell-free extracts of oxalate-grown cells alone.	Oxalates	338-345	lysyl oxidase	Homo sapiens	2-5
32891627-1	2021	Primary hyperoxaluria type 1 (PH1) is a genetic disorder characterized by overproduction of oxalate and eventual kidney failure.	Oxalates	92-99	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
5472155-4	1970	During growth on oxalate, all the organisms contain oxalyl-CoA decarboxylase, formate dehydrogenase and oxalyl-CoA reductase.	Oxalates	17-24	MEXAM1_RS21720	Methylobacterium extorquens AM1	86-99
5472155-7	1970	The pink-pigmented organisms, when grown on oxalate, contain l-serine-glyoxylate aminotransferase and hydroxypyruvate reductase but do not contain glyoxylate carboligase.	Oxalates	44-51	MEXAM1_RS25950	Methylobacterium extorquens AM1	102-127
13631194-8	1959	When diluted back to the volume of parent plasma, to a concentration of 0.2 microgram nitrogen per ml., thrombokinase can slowly activate prothrombin in the presence of oxalate, and without the addition of accessory factors.	Oxalates	169-176	coagulation factor II, thrombin	Bos taurus	138-149
13631194-9	1959	Activation of prothrombin in the presence of oxalate is faster with higher concentrations of thrombokinase.	Oxalates	45-52	coagulation factor II, thrombin	Bos taurus	14-25
34044409-10	2021	The correlation analysis showed that serum oxalate levels were positively correlated with the vascular oxalate levels and serum MDA, AOPP, and TNF-alpha levels, and negatively correlated with superoxide dismutase activity.	Oxalates	43-50	peroxiredoxin 5	Mus musculus	133-137
34044409-10	2021	The correlation analysis showed that serum oxalate levels were positively correlated with the vascular oxalate levels and serum MDA, AOPP, and TNF-alpha levels, and negatively correlated with superoxide dismutase activity.	Oxalates	43-50	tumor necrosis factor	Mus musculus	143-152
32891627-3	2021	However, in PH1 patients homozygous for the G170R mutation, pyridoxine is an enzyme co-factor and decreases urine oxalate excretion (UOx) by reducing hepatic oxalate production.	Oxalates	114-121	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	12-15
33959570-1	2021	Introduction: Oxalate overproduction in Primary Hyperoxaluria type I (PH1) leads to progressive renal failure and systemic oxalate deposition.	Oxalates	14-21	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	70-73
33350326-2	2021	Biallelic mutations in HOGA1 are responsible for primary hyperoxaluria type 3 and result in oxalate overproduction and kidney stone disease.	Oxalates	92-99	4-hydroxy-2-oxoglutarate aldolase 1	Homo sapiens	23-28
33350326-3	2021	Our previous study showed that carriers of HOGA1 mutations have elevated urinary levels of oxalate precursors.	Oxalates	91-98	4-hydroxy-2-oxoglutarate aldolase 1	Homo sapiens	43-48
33870982-2	2021	After the excitation, some of the oxalate molecules return to the electronic ground state on two very different time scales: a fast component of tau = 1.1 +- 0.5 ps comprising 40% of the excited molecules and a much slower component of tau = 0.28 +- 0.05 ns accounting for 15% of the excited molecules.	Oxalates	34-41	microtubule associated protein tau	Homo sapiens	145-148
33870982-2	2021	After the excitation, some of the oxalate molecules return to the electronic ground state on two very different time scales: a fast component of tau = 1.1 +- 0.5 ps comprising 40% of the excited molecules and a much slower component of tau = 0.28 +- 0.05 ns accounting for 15% of the excited molecules.	Oxalates	34-41	microtubule associated protein tau	Homo sapiens	236-239
33959570-1	2021	Introduction: Oxalate overproduction in Primary Hyperoxaluria type I (PH1) leads to progressive renal failure and systemic oxalate deposition.	Oxalates	123-130	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	70-73
33898474-1	2021	Background: Primary hyperoxaluria type 1 (PH1) is a rare monogenic disorder characterized by excessive hepatic production of oxalate leading to recurrent nephrolithiasis, nephrocalcinosis, and progressive kidney damage, often requiring renal replacement therapy (RRT).	Oxalates	125-132	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	42-45
33867828-0	2021	Theaflavin protects against oxalate calcium-induced kidney oxidative stress injury via upregulation of SIRT1.	Oxalates	28-35	sirtuin 1	Mus musculus	103-108
33904662-8	2021	In NHE3 KO cecum, cAMP stimulation of oxalate secretion was impaired suggesting the possibility of a role for NHE3 in this process.	Oxalates	38-45	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	3-7
33789010-1	2021	BACKGROUND: Primary hyperoxaluria type 1 (PH1) is a rare genetic disease caused by hepatic overproduction of oxalate that leads to kidney stones, nephrocalcinosis, kidney failure, and systemic oxalosis.	Oxalates	109-116	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	42-45
33904662-0	2021	The role of NHE3 (Slc9a3) in oxalate and sodium transport by mouse intestine and regulation by cAMP.	Oxalates	29-36	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	12-16
33904662-0	2021	The role of NHE3 (Slc9a3) in oxalate and sodium transport by mouse intestine and regulation by cAMP.	Oxalates	29-36	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	18-24
33002578-2	2021	Alanine glyoxylate aminotransferase (AGT), deficient in PH type 1, is a key enzyme in limiting glyoxylate oxidation to oxalate.	Oxalates	119-126	alanine-glyoxylate aminotransferase	Mus musculus	0-35
33405070-2	2021	By silencing the gene encoding glycolate oxidase, lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of PH1.	Oxalates	125-132	hydroxyacid oxidase 2	Homo sapiens	31-48
33405070-2	2021	By silencing the gene encoding glycolate oxidase, lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of PH1.	Oxalates	125-132	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	228-231
33278384-6	2021	In vitro experiment found that the activation of NRF2/HO-1 can significantly reduce the oxalate-induced oxidative damage and urinary calcium oxalate stone formation, and the relative expression of BMAL1 was increased.	Oxalates	88-95	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
33278384-6	2021	In vitro experiment found that the activation of NRF2/HO-1 can significantly reduce the oxalate-induced oxidative damage and urinary calcium oxalate stone formation, and the relative expression of BMAL1 was increased.	Oxalates	88-95	heme oxygenase 1	Homo sapiens	54-58
33278384-6	2021	In vitro experiment found that the activation of NRF2/HO-1 can significantly reduce the oxalate-induced oxidative damage and urinary calcium oxalate stone formation, and the relative expression of BMAL1 was increased.	Oxalates	88-95	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	197-202
33278384-7	2021	Then overexpression of circadian gene BMAL1 can activate the NRF2/HO-1 pathway and reduce the oxalate-induced oxidative damage.	Oxalates	94-101	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	38-43
33718378-0	2021	Resveratrol Attenuates Oxalate-Induced Renal Oxidative Injury and Calcium Oxalate Crystal Deposition by Regulating TFEB-Induced Autophagy Pathway.	Oxalates	23-30	transcription factor EB	Rattus norvegicus	115-119
33718378-10	2021	These results suggested that RSV regulates oxalate-induced renal inflammation, oxidative injury, and CaOx crystal deposition in vitro and in vivo through the activation of a TFEB-induced autophagy.	Oxalates	43-50	transcription factor EB	Rattus norvegicus	174-178
33352478-2	2021	In this study, Nakamura et al, show that lysosomal damage induced by lysosomotropic agents or oxalate in renal proximal tubule cells causes lipidated LC3 to insert into the lysosomal membrane to activate TRPML1 channels and release Ca2+ from lysosomes.	Oxalates	94-101	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	150-153
33352478-2	2021	In this study, Nakamura et al, show that lysosomal damage induced by lysosomotropic agents or oxalate in renal proximal tubule cells causes lipidated LC3 to insert into the lysosomal membrane to activate TRPML1 channels and release Ca2+ from lysosomes.	Oxalates	94-101	mucolipin TRP cation channel 1	Homo sapiens	204-210
33002578-2	2021	Alanine glyoxylate aminotransferase (AGT), deficient in PH type 1, is a key enzyme in limiting glyoxylate oxidation to oxalate.	Oxalates	119-126	alanine-glyoxylate aminotransferase	Mus musculus	37-40
33241685-5	2020	In the continuous phase, the oxidation of oxalate (C2O42-) produces a strong reducing agent, CO2 -.	Oxalates	42-49	complement C2	Homo sapiens	93-96
33075302-6	2020	Here, we demonstrate that the binding of oxalate, a non-phosphorylated substrate/product analogue, is allosterically enhanced by Fru-1,6-BP.	Oxalates	41-48	zinc finger and BTB domain containing 22	Homo sapiens	129-132
33277533-5	2020	LCN2 expression was upregulated upon oxalate stimulation.	Oxalates	37-44	lipocalin 2	Homo sapiens	0-4
33006369-13	2020	Recombinant PTH attenuated oxalate-mediated cell injury and upregulated NaDC-1 via protein kinase A activation.	Oxalates	27-34	parathyroid hormone	Rattus norvegicus	12-15
32464217-1	2020	Primary hyperoxaluria type I is caused by mutations in the alanine glyoxylate aminotransferase gene (AGXT), leading to accumulation of glyoxylate and subsequent production of oxalate and urolithiasis.	Oxalates	175-182	alanine--glyoxylate and serine--pyruvate aminotransferase	Rattus norvegicus	59-94
32946238-4	2020	The formation constants determined by deconvolution of the absorption spectra showed a linear decrease for the three ligands (oxalate (Ox), malonate (Mal), and succinate (Suc)) and a mild decrease for the remaining ligands (glutarate (Glu) and adipate (Adi)).	Oxalates	126-133	hypocretin neuropeptide precursor	Homo sapiens	135-137
32871086-0	2020	Melatonin inhibits oxalate-induced endoplasmic reticulum stress and apoptosis in HK-2 cells by activating the AMPK pathway.	Oxalates	19-26	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	110-114
32871086-8	2020	CONCLUSION: Our study revealed that the protective effects of melatonin on oxalate-induced ER stress and apoptosis is partly dependent on AMPK activation in HK-2 cells.	Oxalates	75-82	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	138-142
32464217-1	2020	Primary hyperoxaluria type I is caused by mutations in the alanine glyoxylate aminotransferase gene (AGXT), leading to accumulation of glyoxylate and subsequent production of oxalate and urolithiasis.	Oxalates	175-182	alanine--glyoxylate and serine--pyruvate aminotransferase	Rattus norvegicus	101-105
32989250-4	2020	Furthermore, we demonstrate the presence and importance of this TFEB activation mechanism in kidneys in a mouse model of oxalate nephropathy accompanying lysosomal damage.	Oxalates	121-128	transcription factor EB	Mus musculus	64-68
32989250-5	2020	A proximal tubule-specific TFEB-knockout mouse exhibited progression of kidney injury induced by oxalate crystals.	Oxalates	97-104	transcription factor EB	Mus musculus	27-31
33305106-1	2020	Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disease caused by the functional defect of alanine-glyoxylate aminotransferase that results in the overproduction of oxalate.	Oxalates	178-185	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
33305106-1	2020	Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disease caused by the functional defect of alanine-glyoxylate aminotransferase that results in the overproduction of oxalate.	Oxalates	178-185	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	104-139
32660969-4	2020	The oxalate transporter Slc26a6 is a candidate for contributing to the extrarenal clearance of oxalate via the gut in CKD.	Oxalates	4-11	solute carrier family 26 member 6	Homo sapiens	24-31
32660969-9	2020	This increase was abrogated in Slc26a6 -/- mice associated with a significant elevation in plasma oxalate concentration.	Oxalates	98-105	solute carrier family 26, member 6	Mus musculus	31-38
32660969-12	2020	CONCLUSIONS: Slc26a6-mediated enteric oxalate secretion is critical in decreasing the body burden of oxalate in murine CKD models.	Oxalates	38-45	solute carrier family 26, member 6	Mus musculus	13-20
32660969-12	2020	CONCLUSIONS: Slc26a6-mediated enteric oxalate secretion is critical in decreasing the body burden of oxalate in murine CKD models.	Oxalates	101-108	solute carrier family 26, member 6	Mus musculus	13-20
31821850-4	2020	We have recently reported that the metabolism of trans-4-hydroxy-L-proline (Hyp), an amino acid derived predominantly from collagen metabolism, is a significant source of oxalate production in individuals with PH2 and PH3.	Oxalates	171-178	polyhomeotic homolog 2	Homo sapiens	210-213
32418144-1	2020	BACKGROUND: Primary hyperoxaluria type 1 (PH1) is a multisystemic metabolic disorder caused by an excessive production of oxalate by the liver.	Oxalates	122-129	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	42-45
32691025-1	2020	A new paramagnetic heteronuclear complex formulated as [K3Fe(mu-ox)3(H2O)3]n (1), where ox2- is oxalate, has been synthesized under hydrothermal condition.	Oxalates	96-103	CD200 molecule	Homo sapiens	88-91
32396428-0	2020	Re: miR-155-5p Promotes Oxalate- and Calcium-Induced Kidney Oxidative Stress Injury by Suppressing MGP Expression.	Oxalates	24-31	microRNA 155	Homo sapiens	4-11
32396428-0	2020	Re: miR-155-5p Promotes Oxalate- and Calcium-Induced Kidney Oxidative Stress Injury by Suppressing MGP Expression.	Oxalates	24-31	matrix Gla protein	Homo sapiens	99-102
32658931-0	2020	Correction to Retraction of: Kidney Injury Molecule-1 Is Up-Regulated in Renal Epithelial Cells in Response to Oxalate In Vitro and in Renal Tissues in Response to Hyperoxaluria In Vivo.	Oxalates	111-118	hepatitis A virus cellular receptor 1	Homo sapiens	29-53
32533118-6	2020	Genetic approaches, studying both monogenic and polygenic factors in nephrolithiasis, have revealed that the following have important roles in the aetiology of kidney stones: transporters and channels; ions, protons and amino acids; the calcium-sensing receptor (a G protein-coupled receptor) signalling pathway; and the metabolic pathways for vitamin D, oxalate, cysteine, purines and uric acid.	Oxalates	355-362	calcium sensing receptor	Homo sapiens	237-261
32215174-0	2020	miR-155-5p Promotes Oxalate- and Calcium-Induced Kidney Oxidative Stress Injury by Suppressing MGP Expression.	Oxalates	20-27	matrix Gla protein	Mus musculus	95-98
32215174-3	2020	This study was designed to confirm the potential function of miR-155-5p in the formation of CaOx induced by oxalate and calcium oxalate monohydrate (COM).	Oxalates	108-115	microRNA 155	Mus musculus	61-68
32215174-5	2020	The results of qRT-PCR and western blot showed that expression of NOX2 was upregulated, while that of SOD-2 was downregulated following the treatment with oxalate and COM in HK-2 cells.	Oxalates	155-162	cytochrome b-245, beta polypeptide	Mus musculus	66-70
32215174-5	2020	The results of qRT-PCR and western blot showed that expression of NOX2 was upregulated, while that of SOD-2 was downregulated following the treatment with oxalate and COM in HK-2 cells.	Oxalates	155-162	superoxide dismutase 2, mitochondrial	Mus musculus	102-107
32215174-9	2020	Furthermore, IHC analyses showed strong positive staining intensity for the NOX-2 protein in the high-dose oxalate and Ca2+-treated mouse kidneys, and miR-155-5p overexpression can further enhance its expression.	Oxalates	107-114	cytochrome b-245, beta polypeptide	Mus musculus	76-81
32215174-11	2020	In conclusion, our study indicates that miR-155-5p promotes oxalate- and COM-induced kidney oxidative stress injury by suppressing MGP expression.	Oxalates	60-67	microRNA 155	Mus musculus	40-47
32215174-11	2020	In conclusion, our study indicates that miR-155-5p promotes oxalate- and COM-induced kidney oxidative stress injury by suppressing MGP expression.	Oxalates	60-67	matrix Gla protein	Mus musculus	131-134
31821850-5	2020	Thus, the first enzyme in the Hyp degradation pathway, hydroxyproline dehydrogenase (HYPDH), represents a promising therapeutic target for reducing endogenous oxalate production in these individuals.	Oxalates	159-166	proline dehydrogenase 2	Homo sapiens	85-90
31821850-8	2020	We describe the phenotype of the Prodh2 knock out mouse model and show that the lack of HYPDH in PH mouse models results in lower levels of urinary oxalate excretion, consistent with our previous metabolic tracer and siRNA-based knockdown studies.	Oxalates	148-155	proline dehydrogenase (oxidase) 2	Mus musculus	33-39
31821850-8	2020	We describe the phenotype of the Prodh2 knock out mouse model and show that the lack of HYPDH in PH mouse models results in lower levels of urinary oxalate excretion, consistent with our previous metabolic tracer and siRNA-based knockdown studies.	Oxalates	148-155	proline dehydrogenase 2	Homo sapiens	88-93
31669600-5	2020	EMT was successfully induced by oxalate treatment as indicated by morphological changes into spindle-shape cells, increased expression of mesenchymal proteins (fibronectin, vimentin and alpha-smooth muscle actin (alpha-SMA)), decreased expression of epithelial proteins (E-cadherin and zonula occludens-1 (ZO-1)) and increased activity of a profibrotic factor (matrix metalloproteinase-9 (MMP-9)).	Oxalates	32-39	fibronectin 1	Homo sapiens	160-171
31786192-2	2020	However, its underlying mechanism of inhibiting oxalate and calcium oxalate (CaOx) crystal-induced EMT by activating the PPAR-gamma pathway remains unclear.	Oxalates	48-55	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	121-131
31825428-0	2020	Formation of allylated quaternary carbon centers via C-O/C-O bond fragmentation of oxalates and allyl carbonates.	Oxalates	83-91	DAN domain BMP antagonist family member 5	Homo sapiens	53-60
31523921-2	2020	Here, a thermogelling poly(ethylene glycol)-polycaprolactone-poly(ethylene glycol) (PEG-PCL-PEG or EG12 -CL20 -EG12 ) triblock copolymer with an oxalate group at the middle of the polymer is reported.	Oxalates	145-152	epithelial membrane protein 1	Rattus norvegicus	105-109
31786192-0	2020	Telmisartan inhibits oxalate and calcium oxalate crystal-induced epithelial-mesenchymal transformation via PPAR-gamma-AKT/STAT3/p38 MAPK-Snail pathway.	Oxalates	21-28	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	107-117
31786192-0	2020	Telmisartan inhibits oxalate and calcium oxalate crystal-induced epithelial-mesenchymal transformation via PPAR-gamma-AKT/STAT3/p38 MAPK-Snail pathway.	Oxalates	21-28	AKT serine/threonine kinase 1	Rattus norvegicus	118-121
31786192-0	2020	Telmisartan inhibits oxalate and calcium oxalate crystal-induced epithelial-mesenchymal transformation via PPAR-gamma-AKT/STAT3/p38 MAPK-Snail pathway.	Oxalates	21-28	signal transducer and activator of transcription 3	Rattus norvegicus	122-127
31669600-5	2020	EMT was successfully induced by oxalate treatment as indicated by morphological changes into spindle-shape cells, increased expression of mesenchymal proteins (fibronectin, vimentin and alpha-smooth muscle actin (alpha-SMA)), decreased expression of epithelial proteins (E-cadherin and zonula occludens-1 (ZO-1)) and increased activity of a profibrotic factor (matrix metalloproteinase-9 (MMP-9)).	Oxalates	32-39	vimentin	Homo sapiens	173-181
31669600-5	2020	EMT was successfully induced by oxalate treatment as indicated by morphological changes into spindle-shape cells, increased expression of mesenchymal proteins (fibronectin, vimentin and alpha-smooth muscle actin (alpha-SMA)), decreased expression of epithelial proteins (E-cadherin and zonula occludens-1 (ZO-1)) and increased activity of a profibrotic factor (matrix metalloproteinase-9 (MMP-9)).	Oxalates	32-39	actin alpha 1, skeletal muscle	Homo sapiens	213-222
31669600-5	2020	EMT was successfully induced by oxalate treatment as indicated by morphological changes into spindle-shape cells, increased expression of mesenchymal proteins (fibronectin, vimentin and alpha-smooth muscle actin (alpha-SMA)), decreased expression of epithelial proteins (E-cadherin and zonula occludens-1 (ZO-1)) and increased activity of a profibrotic factor (matrix metalloproteinase-9 (MMP-9)).	Oxalates	32-39	cadherin 1	Homo sapiens	271-281
31669600-5	2020	EMT was successfully induced by oxalate treatment as indicated by morphological changes into spindle-shape cells, increased expression of mesenchymal proteins (fibronectin, vimentin and alpha-smooth muscle actin (alpha-SMA)), decreased expression of epithelial proteins (E-cadherin and zonula occludens-1 (ZO-1)) and increased activity of a profibrotic factor (matrix metalloproteinase-9 (MMP-9)).	Oxalates	32-39	tight junction protein 1	Homo sapiens	286-304
31669600-5	2020	EMT was successfully induced by oxalate treatment as indicated by morphological changes into spindle-shape cells, increased expression of mesenchymal proteins (fibronectin, vimentin and alpha-smooth muscle actin (alpha-SMA)), decreased expression of epithelial proteins (E-cadherin and zonula occludens-1 (ZO-1)) and increased activity of a profibrotic factor (matrix metalloproteinase-9 (MMP-9)).	Oxalates	32-39	tight junction protein 1	Homo sapiens	306-310
31669600-5	2020	EMT was successfully induced by oxalate treatment as indicated by morphological changes into spindle-shape cells, increased expression of mesenchymal proteins (fibronectin, vimentin and alpha-smooth muscle actin (alpha-SMA)), decreased expression of epithelial proteins (E-cadherin and zonula occludens-1 (ZO-1)) and increased activity of a profibrotic factor (matrix metalloproteinase-9 (MMP-9)).	Oxalates	32-39	matrix metallopeptidase 9	Homo sapiens	361-387
31669600-5	2020	EMT was successfully induced by oxalate treatment as indicated by morphological changes into spindle-shape cells, increased expression of mesenchymal proteins (fibronectin, vimentin and alpha-smooth muscle actin (alpha-SMA)), decreased expression of epithelial proteins (E-cadherin and zonula occludens-1 (ZO-1)) and increased activity of a profibrotic factor (matrix metalloproteinase-9 (MMP-9)).	Oxalates	32-39	matrix metallopeptidase 9	Homo sapiens	389-394
31669600-7	2020	Moreover, TRIG also prevented oxalate-induced cell migration, reactive oxygen species (ROS) overproduction, and down-regulation of Nrf-2 signaling molecule.	Oxalates	30-37	NFE2 like bZIP transcription factor 2	Homo sapiens	131-136
31789593-4	2019	We demonstrate that compounds S9 and its oxalate salt S9OX interfere with FOXO3 target promoter binding, gene transcription and modulate the physiologic program activated by FOXO3 in cancer cells.	Oxalates	41-53	forkhead box O3	Homo sapiens	74-79
32792227-1	2020	Primary Hyperoxaluria type I (PH1) is a rare disease caused by mutations in the AGXT gene encoding alanine:glyoxylate aminotransferase (AGT), a liver enzyme involved in the detoxification of glyoxylate, the failure of which results in accumulation of oxalate and kidney stones formation.	Oxalates	251-258	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
32792227-1	2020	Primary Hyperoxaluria type I (PH1) is a rare disease caused by mutations in the AGXT gene encoding alanine:glyoxylate aminotransferase (AGT), a liver enzyme involved in the detoxification of glyoxylate, the failure of which results in accumulation of oxalate and kidney stones formation.	Oxalates	251-258	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	80-84
32792227-1	2020	Primary Hyperoxaluria type I (PH1) is a rare disease caused by mutations in the AGXT gene encoding alanine:glyoxylate aminotransferase (AGT), a liver enzyme involved in the detoxification of glyoxylate, the failure of which results in accumulation of oxalate and kidney stones formation.	Oxalates	251-258	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	99-134
32792227-1	2020	Primary Hyperoxaluria type I (PH1) is a rare disease caused by mutations in the AGXT gene encoding alanine:glyoxylate aminotransferase (AGT), a liver enzyme involved in the detoxification of glyoxylate, the failure of which results in accumulation of oxalate and kidney stones formation.	Oxalates	251-258	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	136-139
32003182-2	2019	The mutations in the AGXT, GRHPR, HOGA1 genes are attributable for different types of primary hyperoxaluria leading to the dysfunction of specific enzymes involved in the oxalate metabolism.	Oxalates	171-178	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	21-25
32003182-2	2019	The mutations in the AGXT, GRHPR, HOGA1 genes are attributable for different types of primary hyperoxaluria leading to the dysfunction of specific enzymes involved in the oxalate metabolism.	Oxalates	171-178	glyoxylate and hydroxypyruvate reductase	Homo sapiens	27-32
32003182-2	2019	The mutations in the AGXT, GRHPR, HOGA1 genes are attributable for different types of primary hyperoxaluria leading to the dysfunction of specific enzymes involved in the oxalate metabolism.	Oxalates	171-178	4-hydroxy-2-oxoglutarate aldolase 1	Homo sapiens	34-39
31882798-1	2019	Oxalate crystal-induced renal inflammation is associated with progressive kidney failure due to activation of the NLRP3/CASP-1 inflammasome.	Oxalates	0-7	NLR family, pyrin domain containing 3	Mus musculus	114-119
31882798-1	2019	Oxalate crystal-induced renal inflammation is associated with progressive kidney failure due to activation of the NLRP3/CASP-1 inflammasome.	Oxalates	0-7	caspase 1	Mus musculus	120-126
31789593-4	2019	We demonstrate that compounds S9 and its oxalate salt S9OX interfere with FOXO3 target promoter binding, gene transcription and modulate the physiologic program activated by FOXO3 in cancer cells.	Oxalates	41-53	forkhead box O3	Homo sapiens	174-179
31696211-8	2019	We also propose that loss of HOGA1 function could increase oxalate production in PH3 by decreasing pyruvate availability and metabolic flux through the Krebs cycle.	Oxalates	59-66	4-hydroxy-2-oxoglutarate aldolase 1	Homo sapiens	29-34
31591464-8	2019	A lactate dehydrogenase (LDH, encoded by a ldh) could possibly mediate the conversion from glyoxylate to oxalate based on our RNA-seq profiles.	Oxalates	105-112	D-lactate dehydrogenase	Acinetobacter oleivorans DR1	2-23
31781338-7	2019	Our results showed that, both in vitro and in vivo, oxalate impaired PPAR-gamma expression and phosphorylation, and then accumulative ROS production was observed, accompanied by enhanced TGF-beta1 and reduced HGF.	Oxalates	52-59	peroxisome proliferator activated receptor gamma	Canis lupus familiaris	69-79
31781338-7	2019	Our results showed that, both in vitro and in vivo, oxalate impaired PPAR-gamma expression and phosphorylation, and then accumulative ROS production was observed, accompanied by enhanced TGF-beta1 and reduced HGF.	Oxalates	52-59	transforming growth factor beta-1 proprotein	Canis lupus familiaris	187-196
31781338-7	2019	Our results showed that, both in vitro and in vivo, oxalate impaired PPAR-gamma expression and phosphorylation, and then accumulative ROS production was observed, accompanied by enhanced TGF-beta1 and reduced HGF.	Oxalates	52-59	hepatocyte growth factor	Canis lupus familiaris	209-212
31781338-11	2019	Our results revealed that the reduction of PPAR-gamma activity played a critical role in oxalate-induced ROS damage and CaOx stone formation.	Oxalates	89-96	peroxisome proliferator activated receptor gamma	Canis lupus familiaris	43-53
31591464-8	2019	A lactate dehydrogenase (LDH, encoded by a ldh) could possibly mediate the conversion from glyoxylate to oxalate based on our RNA-seq profiles.	Oxalates	105-112	D-lactate dehydrogenase	Acinetobacter oleivorans DR1	25-28
31591464-8	2019	A lactate dehydrogenase (LDH, encoded by a ldh) could possibly mediate the conversion from glyoxylate to oxalate based on our RNA-seq profiles.	Oxalates	105-112	D-lactate dehydrogenase	Acinetobacter oleivorans DR1	43-46
31591464-9	2019	Oxalate production during hexadecane degradation and impaired growth of a DeltaldhDeltaglcB double mutant in both acetate and hexadecane-supplemented media suggested that LDH is a potential detoxifying enzyme for glyoxylate.	Oxalates	0-7	D-lactate dehydrogenase	Acinetobacter oleivorans DR1	171-174
31591464-11	2019	The LDH-overexpressing E. coli strain, but not wild type strain, produced oxalate under glyoxylate condition.	Oxalates	74-81	D-lactate dehydrogenase	Acinetobacter oleivorans DR1	4-7
31402115-1	2019	Primary hyperoxaluria type 1 (PH1) is an inherited metabolic disorder caused by a deficiency of the peroxisomal enzyme alanine-glyoxylate aminotransferase (AGT), which leads to overproduction of oxalate by the liver and results in urolithiasis, nephrocalcinosis and renal failure.	Oxalates	195-202	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	119-154
31402115-1	2019	Primary hyperoxaluria type 1 (PH1) is an inherited metabolic disorder caused by a deficiency of the peroxisomal enzyme alanine-glyoxylate aminotransferase (AGT), which leads to overproduction of oxalate by the liver and results in urolithiasis, nephrocalcinosis and renal failure.	Oxalates	195-202	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	156-159
31402115-1	2019	Primary hyperoxaluria type 1 (PH1) is an inherited metabolic disorder caused by a deficiency of the peroxisomal enzyme alanine-glyoxylate aminotransferase (AGT), which leads to overproduction of oxalate by the liver and results in urolithiasis, nephrocalcinosis and renal failure.	Oxalates	195-202	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
31296606-2	2019	Established contributors to oxalate crystal-induced renal necroinflammation include the NACHT, LRR and PYD domains-containing protein-3 (NLRP3) inflammasome and mixed lineage kinase domain-like (MLKL) protein-dependent tubule necroptosis.	Oxalates	28-35	NLR family, pyrin domain containing 3	Mus musculus	88-135
31296606-2	2019	Established contributors to oxalate crystal-induced renal necroinflammation include the NACHT, LRR and PYD domains-containing protein-3 (NLRP3) inflammasome and mixed lineage kinase domain-like (MLKL) protein-dependent tubule necroptosis.	Oxalates	28-35	NLR family, pyrin domain containing 3	Mus musculus	137-142
31296606-8	2019	Mice lacking Ppif or Mlkl or given an inhibitor of mitochondrial permeability transition displayed attenuated oxalate-induced AKI.	Oxalates	110-117	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	13-17
31296606-8	2019	Mice lacking Ppif or Mlkl or given an inhibitor of mitochondrial permeability transition displayed attenuated oxalate-induced AKI.	Oxalates	110-117	mixed lineage kinase domain-like	Mus musculus	21-25
31276320-3	2019	Furthermore, due to the continuous chelating reaction with the oxalate ion, chloride anions from the mixed-halide CsPb(Cl/Br)3 perovskite NCs could be extracted, and green emitting CsPbBr3 NCs with PL QY of 85% at 511 nm emission are obtained.	Oxalates	63-70	granzyme B	Homo sapiens	114-118
31042422-1	2019	Putative anion transporter 1 (PAT1, SLC26A6), an intestinal epithelial Cl-/ HCO3- exchanger, also plays a key role in oxalate homeostasis via mediating intestinal oxalate secretion.	Oxalates	118-125	solute carrier family 36 member 1	Homo sapiens	0-28
31042422-1	2019	Putative anion transporter 1 (PAT1, SLC26A6), an intestinal epithelial Cl-/ HCO3- exchanger, also plays a key role in oxalate homeostasis via mediating intestinal oxalate secretion.	Oxalates	118-125	solute carrier family 36 member 1	Homo sapiens	30-34
31042422-1	2019	Putative anion transporter 1 (PAT1, SLC26A6), an intestinal epithelial Cl-/ HCO3- exchanger, also plays a key role in oxalate homeostasis via mediating intestinal oxalate secretion.	Oxalates	118-125	solute carrier family 26 member 6	Homo sapiens	36-43
31926579-0	2019	Apoptosis of human kidney epithelial cells induced by high oxalate and calcium oxalate monohydrate is apurinic/apyrimidinic endonuclease 1 pathway dependent and contributes to kidney stone formation.	Oxalates	59-66	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	102-138
31926579-6	2019	Therefore, we investigated the changes of APE1 protein expression in the human kidney epithelial cell line (HK-2) by exposing them to high oxalate and COM in various conditions.	Oxalates	139-146	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	42-46
31475403-8	2019	High-calcium and high-oxalate challenge initially enhances surface expression of annexin A1 and alpha-enolase, respectively, both of which return to their basal levels by estrogen.	Oxalates	22-29	annexin A1	Canis lupus familiaris	81-91
31475403-8	2019	High-calcium and high-oxalate challenge initially enhances surface expression of annexin A1 and alpha-enolase, respectively, both of which return to their basal levels by estrogen.	Oxalates	22-29	enolase 1	Canis lupus familiaris	96-109
31178964-5	2019	Mechanism study results showed that ERbeta suppressed oxalate-induced oxidative stress via transcriptional suppression of the NADPH oxidase subunit 2 (NOX2) through direct binding to the estrogen response elements (EREs) on the NOX2 5" promoter.	Oxalates	54-61	cytochrome b-245, beta polypeptide	Mus musculus	126-149
31943995-1	2019	An oxalate-bridged binuclear iron(III) ionic liquid combined with an imidazolium based cation, (dimim)2 [Fe2 Cl4 (mu-ox)], was synthesized and characterized by a wide range of techniques.	Oxalates	3-10	endogenous retrovirus group W member 3	Homo sapiens	109-112
30169827-5	2019	In experimental models using oxalate-enriched chow, CaOx crystals were bound to renal tubular cells, promoting a pro-inflammatory environment that led to fibrogenesis in the renal parenchyma by activation of a NACHT, LRR and PYD domains-containing protein 3 (NALP3)-dependent inflammasome in renal dendritic cells and macrophages.	Oxalates	29-36	NLR family pyrin domain containing 3	Homo sapiens	210-257
30169827-5	2019	In experimental models using oxalate-enriched chow, CaOx crystals were bound to renal tubular cells, promoting a pro-inflammatory environment that led to fibrogenesis in the renal parenchyma by activation of a NACHT, LRR and PYD domains-containing protein 3 (NALP3)-dependent inflammasome in renal dendritic cells and macrophages.	Oxalates	29-36	NLR family pyrin domain containing 3	Homo sapiens	259-264
31178964-5	2019	Mechanism study results showed that ERbeta suppressed oxalate-induced oxidative stress via transcriptional suppression of the NADPH oxidase subunit 2 (NOX2) through direct binding to the estrogen response elements (EREs) on the NOX2 5" promoter.	Oxalates	54-61	cytochrome b-245, beta polypeptide	Mus musculus	151-155
31178964-5	2019	Mechanism study results showed that ERbeta suppressed oxalate-induced oxidative stress via transcriptional suppression of the NADPH oxidase subunit 2 (NOX2) through direct binding to the estrogen response elements (EREs) on the NOX2 5" promoter.	Oxalates	54-61	cytochrome b-245, beta polypeptide	Mus musculus	228-232
30701361-8	2019	Additionally, calcium- and oxalate-affinity assays confirmed depletion of both calcium and oxalate ions after incubation with fibronectin.	Oxalates	27-34	fibronectin 1	Homo sapiens	126-137
30599261-0	2019	Inhibiting inflammation and modulating oxidative stress in oxalate-induced nephrolithiasis with the Nrf2 activator dimethyl fumarate.	Oxalates	59-66	NFE2 like bZIP transcription factor 2	Rattus norvegicus	100-104
30599261-2	2019	This study aimed to investigate whether nuclear factor (erythroid-derived 2)-like 2 (Nrf2, also called Nfe2l2) induced by dimethyl fumarate (DMF) could protect renal epithelial cells against oxalate-mediated injury both in vivo and in vitro.	Oxalates	191-198	NFE2 like bZIP transcription factor 2	Rattus norvegicus	40-83
30599261-2	2019	This study aimed to investigate whether nuclear factor (erythroid-derived 2)-like 2 (Nrf2, also called Nfe2l2) induced by dimethyl fumarate (DMF) could protect renal epithelial cells against oxalate-mediated injury both in vivo and in vitro.	Oxalates	191-198	NFE2 like bZIP transcription factor 2	Rattus norvegicus	85-89
30599261-2	2019	This study aimed to investigate whether nuclear factor (erythroid-derived 2)-like 2 (Nrf2, also called Nfe2l2) induced by dimethyl fumarate (DMF) could protect renal epithelial cells against oxalate-mediated injury both in vivo and in vitro.	Oxalates	191-198	NFE2 like bZIP transcription factor 2	Rattus norvegicus	103-109
30907303-3	2019	Alanine glyoxylate aminotransferase-1 and glyoxylate reductase, the enzymes involving glyoxylate (precursor for oxalate) metabolism, have been related to primary hyperoxalurias.	Oxalates	112-119	glyoxylate and hydroxypyruvate reductase	Homo sapiens	0-62
30907303-11	2019	Kynurenine aminotransferase-III is, so far, the most efficient putative mitochondrial enzyme to transaminate glyoxylate to glycine in mammalian livers, might be an interesting enzyme to look over in hyperoxaluria etiology of primary hyperoxaluria and should be carefully investigated for its involvement in oxalate metabolism.	Oxalates	307-314	kynurenine aminotransferase 3	Homo sapiens	0-31
30873581-3	2019	Of the 11 described SLC26 isoforms, the SLC26A1,2,3,6,7,9,11 are expressed in the gastrointestinal tract, where they participate in salt and water transport, surface pH-microclimate regulation, affect the microbiome composition, the absorption, and secretion of oxalate and sulfate, and other functions that require further study.	Oxalates	262-269	solute carrier family 26 member 1	Homo sapiens	40-47
30504042-5	2019	This could be attributed by oxalate, the final product of AH2 decomposition, which strongly competed with As(V) for Fe(II) at higher pH or lower Fe/As molar ratio, inhibiting parasymplesite accumulation and then causing more As mobilization.	Oxalates	28-35	zinc finger RANBP2-type containing 3	Homo sapiens	58-61
30317563-0	2019	Peroxisome proliferator-activated receptor gamma modulates renal crystal retention associated with high oxalate concentration by regulating tubular epithelial cellular transdifferentiation.	Oxalates	104-111	peroxisome proliferator activated receptor gamma	Canis lupus familiaris	0-48
30317563-3	2019	In the current study, we found that temporarily high oxalate concentration significantly decreased PPARgamma expression, induced Madin Darby Canine Kidney cell dedifferentiation, and prompted subsequent calcium oxalate (CaOx) crystal adhesion in vitro.	Oxalates	53-60	peroxisome proliferator activated receptor gamma	Canis lupus familiaris	99-108
30317563-4	2019	Furthermore, cell redifferentiation after the removal of the high oxalate concentration, along with a decreasing affinity to crystals, was an endogenic PPARgamma-dependent process.	Oxalates	66-73	peroxisome proliferator activated receptor gamma	Canis lupus familiaris	152-161
30317563-5	2019	In addition, the PPARgamma antagonist GW9662, which can depress total-PPARgamma expression and activity, enhanced cell dedifferentiation induced by high oxalate concentration and inhibited cell redifferentiation after removal of the high oxalate concentration.	Oxalates	153-160	peroxisome proliferator activated receptor gamma	Canis lupus familiaris	17-26
30317563-5	2019	In addition, the PPARgamma antagonist GW9662, which can depress total-PPARgamma expression and activity, enhanced cell dedifferentiation induced by high oxalate concentration and inhibited cell redifferentiation after removal of the high oxalate concentration.	Oxalates	238-245	peroxisome proliferator activated receptor gamma	Canis lupus familiaris	17-26
30837228-0	2019	Simultaneous expression of ClopHensor and SLC26A3 reveals the nature of endogenous oxalate transport in CHO cells.	Oxalates	83-90	chloride anion exchanger	Cricetulus griseus	42-49
30837228-5	2019	SLC26A3, a known anion exchanger, has been proposed to play a role in colonic oxalate absorption in humans.	Oxalates	78-85	solute carrier family 26 member 3	Homo sapiens	0-7
30837228-6	2019	Our attempt to study the role of SLC26A3 in oxalate transport revealed the presence of an endogenous oxalate transporter in CHO cells.	Oxalates	44-51	chloride anion exchanger	Cricetulus griseus	33-40
30676254-2	2019	Loss of alanine glyoxylate aminotransferase (AGT) function to convert intermediate metabolite glyoxylate to glycine causes the accumulation and reduction of glyoxylate to glycolate, which eventually is oxidized to oxalate.	Oxalates	214-221	alanine-glyoxylate aminotransferase	Mus musculus	8-43
30676254-2	2019	Loss of alanine glyoxylate aminotransferase (AGT) function to convert intermediate metabolite glyoxylate to glycine causes the accumulation and reduction of glyoxylate to glycolate, which eventually is oxidized to oxalate.	Oxalates	214-221	alanine-glyoxylate aminotransferase	Mus musculus	45-48
30676254-3	2019	Excess oxalate in PH1 patients leads to the formation and deposition of calcium oxalate crystals in the kidney and urinary tract.	Oxalates	7-14	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	18-21
30676254-9	2019	Repeat dosing in Agxt-/- mice resulted in a 40% reduction in urinary oxalate, suggesting therapeutic benefit.	Oxalates	69-76	alanine-glyoxylate aminotransferase	Mus musculus	17-21
30676254-10	2019	These studies suggest that mRNA encoding AGT led to increased expression and activity of the AGT enzyme in liver that translated into decrease in urinary oxalate levels.	Oxalates	154-161	alanine-glyoxylate aminotransferase	Mus musculus	41-44
30676254-10	2019	These studies suggest that mRNA encoding AGT led to increased expression and activity of the AGT enzyme in liver that translated into decrease in urinary oxalate levels.	Oxalates	154-161	alanine-glyoxylate aminotransferase	Mus musculus	93-96
30701361-8	2019	Additionally, calcium- and oxalate-affinity assays confirmed depletion of both calcium and oxalate ions after incubation with fibronectin.	Oxalates	91-98	fibronectin 1	Homo sapiens	126-137
30383413-1	2019	The anion exchanger SAT-1 [sulfate anion transporter 1 (Slc26a1)] is considered an important regulator of oxalate and sulfate homeostasis, but the mechanistic basis of these critical roles remain undetermined.	Oxalates	106-113	spermidine/spermine N1-acetyl transferase 1	Mus musculus	20-25
30276532-1	2019	BACKGROUND: Primary hyperoxaluria type 1 (PH1) is an orphan inborn error of oxalate metabolism leading to hyperoxaluria, progressive renal failure, oxalate deposition, and increased cardiovascular complications.	Oxalates	76-83	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	42-45
30307745-5	2019	ob Mice have significantly higher jejunal (1.6-fold) and ileal (1.4-fold) paracellular oxalate absorption ex vivo and significantly higher (5-fold) urine [13C]oxalate following oral gavage with [13C]oxalate, indicating increased intestinal oxalate absorption in vivo.	Oxalates	159-166	leptin	Mus musculus	0-2
30307745-12	2019	A transepithelial oxalate concentration gradient driving gastrointestinal paracellular oxalate absorption exists, and therefore, our novel findings likely contribute to the hyperoxaluria observed in the ob/ob mice and hence to the pathogenesis of obesity-associated hyperoxaluria.	Oxalates	18-25	leptin	Mus musculus	187-189
30446806-9	2019	Genetic polymorphisms decreasing CaSR expression could predispose individuals to stones because they may impair CaSR protective effects against precipitation of calcium phosphate and oxalate.	Oxalates	183-190	calcium sensing receptor	Homo sapiens	33-37
30446806-9	2019	Genetic polymorphisms decreasing CaSR expression could predispose individuals to stones because they may impair CaSR protective effects against precipitation of calcium phosphate and oxalate.	Oxalates	183-190	calcium sensing receptor	Homo sapiens	112-116
30307745-5	2019	ob Mice have significantly higher jejunal (1.6-fold) and ileal (1.4-fold) paracellular oxalate absorption ex vivo and significantly higher (5-fold) urine [13C]oxalate following oral gavage with [13C]oxalate, indicating increased intestinal oxalate absorption in vivo.	Oxalates	87-94	leptin	Mus musculus	0-2
30427220-0	2019	Characterization of renal NaCl and oxalate transport in Slc26a6-/- mice.	Oxalates	35-42	solute carrier family 26, member 6	Mus musculus	56-63
30307745-12	2019	A transepithelial oxalate concentration gradient driving gastrointestinal paracellular oxalate absorption exists, and therefore, our novel findings likely contribute to the hyperoxaluria observed in the ob/ob mice and hence to the pathogenesis of obesity-associated hyperoxaluria.	Oxalates	18-25	leptin	Mus musculus	203-205
30383413-1	2019	The anion exchanger SAT-1 [sulfate anion transporter 1 (Slc26a1)] is considered an important regulator of oxalate and sulfate homeostasis, but the mechanistic basis of these critical roles remain undetermined.	Oxalates	106-113	solute carrier family 26 (sulfate transporter), member 1	Mus musculus	27-54
30383413-1	2019	The anion exchanger SAT-1 [sulfate anion transporter 1 (Slc26a1)] is considered an important regulator of oxalate and sulfate homeostasis, but the mechanistic basis of these critical roles remain undetermined.	Oxalates	106-113	solute carrier family 26 (sulfate transporter), member 1	Mus musculus	56-63
30383413-11	2019	NEW & NOTEWORTHY SAT-1 is a membrane-bound transport protein expressed in the intestine, liver, and kidney, where it is widely considered essential for the excretion of oxalate, a potentially toxic waste metabolite.	Oxalates	169-176	spermidine/spermine N1-acetyl transferase 1	Mus musculus	17-22
30427220-8	2019	We conclude that, although SLC26A6 is dispensable for renal NaCl homeostasis, it is required for net renal secretion of oxalate.	Oxalates	120-127	solute carrier family 26, member 6	Mus musculus	27-34
30383413-12	2019	Previously, calcium oxalate kidney stone formation by the SAT-1-knockout mouse generated the hypothesis that SAT-1 has a major role in oxalate excretion via the intestine.	Oxalates	20-27	spermidine/spermine N1-acetyl transferase 1	Mus musculus	58-63
30383413-12	2019	Previously, calcium oxalate kidney stone formation by the SAT-1-knockout mouse generated the hypothesis that SAT-1 has a major role in oxalate excretion via the intestine.	Oxalates	20-27	spermidine/spermine N1-acetyl transferase 1	Mus musculus	109-114
30020825-2	2018	Intestinal oxalate secretion mediated by anion exchanger SLC26A6 (PAT1) plays a crucial role in limiting net absorption of ingested oxalate, thereby preventing hyperoxaluria and related KS, reflecting the importance of understanding regulation of intestinal oxalate transport.	Oxalates	11-18	solute carrier family 26 member 6	Homo sapiens	57-64
30864378-1	2018	Chloride/formate exchanger (CFEX; SLC26A6) mediates oxalate transport in various mammalian organs.	Oxalates	52-59	solute carrier family 26, member 6	Mus musculus	28-32
30864378-1	2018	Chloride/formate exchanger (CFEX; SLC26A6) mediates oxalate transport in various mammalian organs.	Oxalates	52-59	solute carrier family 26 member 6	Homo sapiens	34-41
30020825-7	2018	ADO also significantly inhibited oxalate efflux by C2 cells, which is important since PAT1 mediates oxalate efflux in vivo.	Oxalates	33-40	amyloid beta precursor protein binding protein 2	Homo sapiens	86-90
30020825-7	2018	ADO also significantly inhibited oxalate efflux by C2 cells, which is important since PAT1 mediates oxalate efflux in vivo.	Oxalates	100-107	amyloid beta precursor protein binding protein 2	Homo sapiens	86-90
30020825-2	2018	Intestinal oxalate secretion mediated by anion exchanger SLC26A6 (PAT1) plays a crucial role in limiting net absorption of ingested oxalate, thereby preventing hyperoxaluria and related KS, reflecting the importance of understanding regulation of intestinal oxalate transport.	Oxalates	11-18	amyloid beta precursor protein binding protein 2	Homo sapiens	66-70
30020825-2	2018	Intestinal oxalate secretion mediated by anion exchanger SLC26A6 (PAT1) plays a crucial role in limiting net absorption of ingested oxalate, thereby preventing hyperoxaluria and related KS, reflecting the importance of understanding regulation of intestinal oxalate transport.	Oxalates	132-139	solute carrier family 26 member 6	Homo sapiens	57-64
30020825-2	2018	Intestinal oxalate secretion mediated by anion exchanger SLC26A6 (PAT1) plays a crucial role in limiting net absorption of ingested oxalate, thereby preventing hyperoxaluria and related KS, reflecting the importance of understanding regulation of intestinal oxalate transport.	Oxalates	132-139	amyloid beta precursor protein binding protein 2	Homo sapiens	66-70
30020825-2	2018	Intestinal oxalate secretion mediated by anion exchanger SLC26A6 (PAT1) plays a crucial role in limiting net absorption of ingested oxalate, thereby preventing hyperoxaluria and related KS, reflecting the importance of understanding regulation of intestinal oxalate transport.	Oxalates	132-139	solute carrier family 26 member 6	Homo sapiens	57-64
30020825-8	2018	Using pharmacological antagonists and A2B adenosine receptor (A2B AR) siRNA knockdown studies, we observed that ADO inhibits oxalate transport through the A2B AR, phospholipase C, and PKC.	Oxalates	125-132	adenosine A2b receptor	Mus musculus	62-68
30020825-8	2018	Using pharmacological antagonists and A2B adenosine receptor (A2B AR) siRNA knockdown studies, we observed that ADO inhibits oxalate transport through the A2B AR, phospholipase C, and PKC.	Oxalates	125-132	adenosine A2b receptor	Mus musculus	155-161
30020825-2	2018	Intestinal oxalate secretion mediated by anion exchanger SLC26A6 (PAT1) plays a crucial role in limiting net absorption of ingested oxalate, thereby preventing hyperoxaluria and related KS, reflecting the importance of understanding regulation of intestinal oxalate transport.	Oxalates	132-139	amyloid beta precursor protein binding protein 2	Homo sapiens	66-70
30020825-9	2018	ADO inhibits oxalate transport by reducing PAT1 surface expression as shown by biotinylation studies.	Oxalates	13-20	amyloid beta precursor protein binding protein 2	Homo sapiens	43-47
30409714-4	2018	In cultured DRG neurons, riluzole suppressed oxalate-induced increase of the number of menthol (TRPM8 agonist)-sensitive cells.	Oxalates	45-52	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	96-101
30020825-10	2018	We conclude that ADO inhibits oxalate transport by lowering PAT1 surface expression in C2 cells through signaling pathways including the A2B AR, PKC, and phospholipase C. Given higher ADO levels and overexpression of the A2B AR in inflammatory bowel disease (IBD), our findings have potential relevance to pathophysiology of IBD-associated hyperoxaluria and related KS.	Oxalates	30-37	solute carrier family 26, member 6	Mus musculus	60-64
30020825-10	2018	We conclude that ADO inhibits oxalate transport by lowering PAT1 surface expression in C2 cells through signaling pathways including the A2B AR, PKC, and phospholipase C. Given higher ADO levels and overexpression of the A2B AR in inflammatory bowel disease (IBD), our findings have potential relevance to pathophysiology of IBD-associated hyperoxaluria and related KS.	Oxalates	30-37	adenosine A2b receptor	Mus musculus	221-227
29236977-6	2018	We next performed experimental validation in two different real-case drug repositioning scenarios: (i) upregulation of the glutamate-pyruvate transaminase (GPT), which has been shown to induce reduction of oxalate levels in a mouse model of primary hyperoxaluria, and (ii) activation of the transcription factor TFEB, a master regulator of lysosomal biogenesis and autophagy, whose modulation may be beneficial in neurodegenerative disorders.	Oxalates	206-213	glutamic pyruvic transaminase, soluble	Mus musculus	156-159
30409714-2	2018	We previously reported oxalate derived from oxaliplatin induced cold allodynia via overexpression of transient receptor potential melastatin 8 (TRPM8) in the dorsal root ganglion (DRG) in rats.	Oxalates	23-30	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	101-142
30409714-2	2018	We previously reported oxalate derived from oxaliplatin induced cold allodynia via overexpression of transient receptor potential melastatin 8 (TRPM8) in the dorsal root ganglion (DRG) in rats.	Oxalates	23-30	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	144-149
30405874-0	2018	Downregulated Expression of Solute Carrier Family 26 Member 6 in NRK-52E Cells Attenuates Oxalate-Induced Intracellular Oxidative Stress.	Oxalates	90-97	solute carrier family 26 member 6	Rattus norvegicus	28-61
30405874-1	2018	Solute carrier family 26 member 6 (Slc26a6), which is mainly expressed in the intestines and kidneys, is a multifunctional anion transporter that is crucial in the transport of oxalate anions.	Oxalates	177-184	solute carrier family 26 member 6	Rattus norvegicus	0-33
30405874-1	2018	Solute carrier family 26 member 6 (Slc26a6), which is mainly expressed in the intestines and kidneys, is a multifunctional anion transporter that is crucial in the transport of oxalate anions.	Oxalates	177-184	solute carrier family 26 member 6	Rattus norvegicus	35-42
30405874-2	2018	This study is aimed at investigating the effect of Slc26a6 expression on oxalate-induced cell oxidation and crystal formation.	Oxalates	73-80	solute carrier family 26 member 6	Rattus norvegicus	51-58
30319631-9	2018	Genetic ablation of ptx3 in nephrocalcinosis un-susceptible B6;129 mice was sufficient to raise the oxalate nephropathy phenotype observed in susceptible strains.	Oxalates	100-107	pentraxin related gene	Mus musculus	20-24
29653411-4	2018	In addition, oxalate-induced p38 phosphorylation was significantly attenuated by chloroquine pretreatment but was markedly enhanced by rapamycin pretreatment, whereas the protective effect of chloroquine on rat renal tubular cell oxidative injury was partly reversed by a p38 protein kinase activator anisomycin.	Oxalates	13-20	mitogen activated protein kinase 14	Rattus norvegicus	29-32
29653411-4	2018	In addition, oxalate-induced p38 phosphorylation was significantly attenuated by chloroquine pretreatment but was markedly enhanced by rapamycin pretreatment, whereas the protective effect of chloroquine on rat renal tubular cell oxidative injury was partly reversed by a p38 protein kinase activator anisomycin.	Oxalates	13-20	mitogen activated protein kinase 14	Rattus norvegicus	272-275
29653411-5	2018	Furthermore, the knockdown of Beclin1 represented similar effects to chloroquine on oxalate-induced cell oxidative injury and p38 phosphorylation in vitro.	Oxalates	84-91	beclin 1	Rattus norvegicus	30-37
29653411-6	2018	Taken together, our results revealed that autophagy inhibition could attenuate oxalate-induced oxidative injury of renal tubular cell and CaOx crystal depositions in the rat kidney via, at least in part, inhibiting the activation of p38 signaling pathway, thus representing a novel role of autophagy in the regulation of oxalate-induced renal oxidative injury and CaOx crystal depositions for the first time.	Oxalates	79-86	mitogen activated protein kinase 14	Rattus norvegicus	233-236
29653411-6	2018	Taken together, our results revealed that autophagy inhibition could attenuate oxalate-induced oxidative injury of renal tubular cell and CaOx crystal depositions in the rat kidney via, at least in part, inhibiting the activation of p38 signaling pathway, thus representing a novel role of autophagy in the regulation of oxalate-induced renal oxidative injury and CaOx crystal depositions for the first time.	Oxalates	321-328	mitogen activated protein kinase 14	Rattus norvegicus	233-236
30405874-8	2018	In the vitro study, compared to the control group, downregulated Slc26a6 NRK cells showed alleviation of the cell viability decrease, cell apoptosis rate, ROS generation, and SOD activity decrease after oxalate treatment.	Oxalates	203-210	solute carrier family 26 member 6	Rattus norvegicus	65-72
29883864-4	2018	In the presence of oxalate, Fe(III)-oxalate complexes formed on Sch [or Sch*-As(V)] could be converted into Fe(II)-oxalate by photo-generated electrons under UV illumination, and more total dissolved Fe produced compared to that without oxalate.	Oxalates	19-26	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	72-82
29883864-4	2018	In the presence of oxalate, Fe(III)-oxalate complexes formed on Sch [or Sch*-As(V)] could be converted into Fe(II)-oxalate by photo-generated electrons under UV illumination, and more total dissolved Fe produced compared to that without oxalate.	Oxalates	36-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	72-82
29883864-7	2018	However, in the presence of oxalate, UV irradiation resulted in the mobilization of As(V) declined by 14-36.5 times compared to that in the dark.	Oxalates	28-35	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	84-89
29883864-8	2018	This study enhanced our understanding on the mobilization of As(V), and UV irradiation could contribute to the immobilization of As(V) on Sch in the aquatic environments containing oxalate.	Oxalates	181-188	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	61-66
29883864-8	2018	This study enhanced our understanding on the mobilization of As(V), and UV irradiation could contribute to the immobilization of As(V) on Sch in the aquatic environments containing oxalate.	Oxalates	181-188	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	129-134
30143257-3	2018	In human, GOX is involved in the production of oxalate, which is a key metabolite in the formation of kidney stone.	Oxalates	47-54	hydroxyacid oxidase 1	Homo sapiens	10-13
30002986-1	2018	Background: Solute-linked carrier 26 gene family 6 (SLC26A6), which is mainly expressed in intestines and kidneys, is a multifunctional anion transporter crucial in the transport of oxalate anions.	Oxalates	182-189	solute carrier family 26 member 6	Rattus norvegicus	12-50
30002986-1	2018	Background: Solute-linked carrier 26 gene family 6 (SLC26A6), which is mainly expressed in intestines and kidneys, is a multifunctional anion transporter crucial in the transport of oxalate anions.	Oxalates	182-189	solute carrier family 26 member 6	Rattus norvegicus	52-59
30002986-8	2018	After lentivirus infection, the urinary oxalate concentration and rate of stone formation in lentivirus-Slc26a6-tranfected rats increased remarkably, while lentivirus-siRNA-Slc26a6-transfected rats showed few crystals.	Oxalates	40-47	solute carrier family 26 member 6	Rattus norvegicus	104-111
29588429-8	2018	In patients with PH1, who have the highest urinary excretion of oxalate, the major sources of oxalate remain to be identified.	Oxalates	64-71	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	17-20
29588429-8	2018	In patients with PH1, who have the highest urinary excretion of oxalate, the major sources of oxalate remain to be identified.	Oxalates	94-101	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	17-20
29236977-6	2018	We next performed experimental validation in two different real-case drug repositioning scenarios: (i) upregulation of the glutamate-pyruvate transaminase (GPT), which has been shown to induce reduction of oxalate levels in a mouse model of primary hyperoxaluria, and (ii) activation of the transcription factor TFEB, a master regulator of lysosomal biogenesis and autophagy, whose modulation may be beneficial in neurodegenerative disorders.	Oxalates	206-213	glutamic pyruvic transaminase, soluble	Mus musculus	123-154
29236977-6	2018	We next performed experimental validation in two different real-case drug repositioning scenarios: (i) upregulation of the glutamate-pyruvate transaminase (GPT), which has been shown to induce reduction of oxalate levels in a mouse model of primary hyperoxaluria, and (ii) activation of the transcription factor TFEB, a master regulator of lysosomal biogenesis and autophagy, whose modulation may be beneficial in neurodegenerative disorders.	Oxalates	206-213	transcription factor EB	Mus musculus	312-316
29243158-1	2018	OBJECTIVE: Primary hyperoxaluria type-1 (PH-1) is a rare genetic disorder in which normal hepatic metabolism of glyoxylate is disrupted resulting in diffuse oxalate deposition and end-stage renal disease (ESRD).	Oxalates	157-164	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	11-39
29243158-1	2018	OBJECTIVE: Primary hyperoxaluria type-1 (PH-1) is a rare genetic disorder in which normal hepatic metabolism of glyoxylate is disrupted resulting in diffuse oxalate deposition and end-stage renal disease (ESRD).	Oxalates	157-164	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	41-45
29651290-4	2018	Indeed, both the anti-transforming growth factor (TGF)beta IgG and control IgG1 antibody impaired CaOx crystallization in vitro, and decreased intrarenal CaOx crystal deposition and subsequent CKD in mice on an oxalate-rich diet compared to oxalate-fed control mice.	Oxalates	211-218	transforming growth factor, beta 1	Mus musculus	50-58
29530983-0	2018	The apical anion exchanger Slc26a6 promotes oxalate secretion by murine submandibular gland acinar cells.	Oxalates	44-51	solute carrier family 26, member 6	Mus musculus	27-34
29530983-3	2018	In contrast, in the small intestine, SLC26A6 serves as the major pathway for oxalate secretion.	Oxalates	77-84	solute carrier family 26, member 6	Mus musculus	37-44
29530983-7	2018	CHO-K1 cells transfected with mouse Slc26a6 exchanged Cl- for oxalate and HCO3-, whereas two other anion exchangers known to be expressed in salivary gland acinar cells, Slc4a4 and Slc4a9, mediated little, if any, Cl-/oxalate exchange.	Oxalates	62-69	solute carrier family 26, member 6	Mus musculus	36-43
29530983-7	2018	CHO-K1 cells transfected with mouse Slc26a6 exchanged Cl- for oxalate and HCO3-, whereas two other anion exchangers known to be expressed in salivary gland acinar cells, Slc4a4 and Slc4a9, mediated little, if any, Cl-/oxalate exchange.	Oxalates	218-225	solute carrier family 26, member 6	Mus musculus	36-43
29530983-8	2018	Of note, both Cl-/oxalate exchange and Cl-/HCO3- exchange were significantly reduced in acinar cells isolated from the submandibular glands of Slc26a6-/- mice.	Oxalates	18-25	solute carrier family 26, member 6	Mus musculus	143-150
29530983-9	2018	Oxalate secretion in submandibular saliva also decreased significantly in Slc26a6-/- mice, but HCO3- secretion was unaffected.	Oxalates	0-7	solute carrier family 26, member 6	Mus musculus	74-81
29530983-10	2018	Taken together, our findings indicate that Slc26a6 is located at the apical membrane of salivary gland acinar cells, where it mediates Cl-/oxalate exchange and plays a critical role in the secretion of oxalate into saliva.	Oxalates	139-146	solute carrier family 26, member 6	Mus musculus	43-50
29530983-10	2018	Taken together, our findings indicate that Slc26a6 is located at the apical membrane of salivary gland acinar cells, where it mediates Cl-/oxalate exchange and plays a critical role in the secretion of oxalate into saliva.	Oxalates	202-209	solute carrier family 26, member 6	Mus musculus	43-50
29244539-1	2018	BACKGROUND: Primary hyperoxaluria type 1 (PH1) is a rare congenital metabolic disorder of the glyoxylate pathway, which manifests with nephrocalcinosis, urolithiasis, and end-stage renal failure (ESRD) as well as deposition of oxalate crystals within ocular tissues.	Oxalates	227-234	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	42-45
29651290-4	2018	Indeed, both the anti-transforming growth factor (TGF)beta IgG and control IgG1 antibody impaired CaOx crystallization in vitro, and decreased intrarenal CaOx crystal deposition and subsequent CKD in mice on an oxalate-rich diet compared to oxalate-fed control mice.	Oxalates	241-248	transforming growth factor, beta 1	Mus musculus	50-58
30539697-9	2018	Agxt-deficient rats excreted more oxalate in the urine than WT animals.	Oxalates	34-41	alanine--glyoxylate and serine--pyruvate aminotransferase	Rattus norvegicus	0-4
29198849-6	2018	RESULTS: LAB recombined with the coding gene of ODC could effectively decrease the amount of oxalate in the media and in the urine of rats.	Oxalates	93-100	ornithine decarboxylase 1	Rattus norvegicus	48-51
29198849-10	2018	CONCLUSION: LAB expressing ODC is more efficient in degradation of oxalate in vitro and in vivo than that expressing OxO.	Oxalates	67-74	ornithine decarboxylase 1	Rattus norvegicus	27-30
29515627-9	2018	The exposure of renal epithelial cells to oxalate causes a signaling cascade which leads to apoptosis by p38 mitogen-activated protein kinase pathways.	Oxalates	42-49	mitogen-activated protein kinase 14	Homo sapiens	105-108
29321449-4	2018	The quantitative detection of oxalate ranged from 10 - 1000 muM, with a linear equation, y = 0.0086x + 34.978, and a correlation coefficient (R2) = 0.9994.	Oxalates	30-37	latexin	Homo sapiens	60-63
29430601-6	2018	Graphical abstract ECL intensity-potential profile of 1,3-dihydroxyacetone (DHA) and oxalate.	Oxalates	85-92	C-C motif chemokine ligand 21	Homo sapiens	19-22
28988354-9	2018	The increased stomatal conductance and aperture in transgenic leaves might be ascribed to the increased yield of oxalate in the guard cells with over-expressed AtFDH in chloroplasts.	Oxalates	113-120	formate dehydrogenase	Arabidopsis thaliana	160-165
29307816-9	2018	Only c-Fos expression was elevated during the period of injections in the oxalate group (P<0.05), but this expression reduced after the end of the treatment.	Oxalates	74-81	FBJ osteosarcoma oncogene	Mus musculus	5-10
28752386-4	2017	Whilst this was unlikely to contribute to the hypoglycaemia, hyperglycolic aciduria is a known feature of primary hyperoxaluria type 1 (PH1); therefore oxalate was also measured in urine and found to be elevated.	Oxalates	152-159	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	136-139
29527594-9	2018	Moreover, the absence of this Fgf23 enhancer in an oxalate diet-induced murine CKD model prevented the early onset induction of osseous, renal, and thymic Fgf23 mRNA levels and led to a significant blunting of elevated circulating intact FGF23 levels.	Oxalates	51-58	fibroblast growth factor 23	Mus musculus	30-35
29527594-9	2018	Moreover, the absence of this Fgf23 enhancer in an oxalate diet-induced murine CKD model prevented the early onset induction of osseous, renal, and thymic Fgf23 mRNA levels and led to a significant blunting of elevated circulating intact FGF23 levels.	Oxalates	51-58	fibroblast growth factor 23	Mus musculus	155-160
29527594-9	2018	Moreover, the absence of this Fgf23 enhancer in an oxalate diet-induced murine CKD model prevented the early onset induction of osseous, renal, and thymic Fgf23 mRNA levels and led to a significant blunting of elevated circulating intact FGF23 levels.	Oxalates	51-58	fibroblast growth factor 23	Mus musculus	238-243
29263348-6	2017	Next, oxalate-supported 45Ca2+-uptake experiments and various single-myotube Ca2+ imaging experiments using STIM2-knockdown mouse primary skeletal myotubes have suggested that STIM2 attenuates SERCA1a activity during skeletal muscle contraction, which contributes to the intracellular Ca2+ distribution between the cytosol and the SR at rest.	Oxalates	6-13	stromal interaction molecule 2	Mus musculus	176-181
20301460-1	1993	When AGT activity is absent, glyoxylate is converted to oxalate, which forms insoluble calcium salts that accumulate in the kidney and other organs.	Oxalates	56-63	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	5-8
20301460-8	1993	DIAGNOSIS/TESTING: The diagnosis of PH1 is suspected in an individual with an elevated oxalate to creatinine ratio in urine and an elevated plasma oxalate concentration.	Oxalates	87-94	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	36-39
20301460-8	1993	DIAGNOSIS/TESTING: The diagnosis of PH1 is suspected in an individual with an elevated oxalate to creatinine ratio in urine and an elevated plasma oxalate concentration.	Oxalates	147-154	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	36-39
28875258-5	2017	Since the association of oxalate toxicity and ER stress on renal cell damage is uncertain, the present study is an attempt to elucidate the interaction of GRP78 with oxalate by computational analysis and study the role of ER stress in oxalate-mediated apoptosis in vitro and in vivo.	Oxalates	166-173	heat shock protein family A (Hsp70) member 5	Homo sapiens	155-160
28875258-5	2017	Since the association of oxalate toxicity and ER stress on renal cell damage is uncertain, the present study is an attempt to elucidate the interaction of GRP78 with oxalate by computational analysis and study the role of ER stress in oxalate-mediated apoptosis in vitro and in vivo.	Oxalates	166-173	heat shock protein family A (Hsp70) member 5	Homo sapiens	155-160
28875258-6	2017	Molecular docking results showed that GRP78-oxalate/CaOx interaction takes place.	Oxalates	44-51	heat shock protein family A (Hsp70) member 5	Homo sapiens	38-43
28875258-7	2017	Oxalate stress significantly up-regulated expression of ER stress markers GRP78 and CHOP both in vitro and in vivo.	Oxalates	0-7	heat shock protein family A (Hsp70) member 5	Homo sapiens	74-79
28875258-7	2017	Oxalate stress significantly up-regulated expression of ER stress markers GRP78 and CHOP both in vitro and in vivo.	Oxalates	0-7	DNA damage inducible transcript 3	Homo sapiens	84-88
29144803-1	2017	OBJECTIVE: Primary hyperoxaluria type 1 (PH1) is a rare metabolic disorder of oxalate overproduction.	Oxalates	78-85	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	41-44
29168724-2	2017	Thermodynamic analysis of four possible additives, Na2CO3, Na2C2O4, NaF and Na2SO4, indicated that both carbonate and oxalate could potentially provide effective separation of Ca via precipitation from Mg in FGD wastewater.	Oxalates	118-125	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
28039904-2	2017	The gene AAE3 was recently identified to encode an oxalyl-CoA synthetase (OCS) in Arabidopsis that catalyses the conversion of oxalate and CoA into oxalyl-CoA.	Oxalates	127-134	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	9-13
28577929-0	2017	MRP-1 and BCRP Promote the Externalization of Phosphatidylserine in Oxalate-treated Renal Epithelial Cells: Implications for Calcium Oxalate Urolithiasis.	Oxalates	68-75	ATP binding cassette subfamily C member 1	Rattus norvegicus	0-5
28577929-1	2017	OBJECTIVE: To investigate the possible involvement of multidrug resistance-associated protein 1 (MRP-1) and breast cancer resistance protein (BCRP) in the oxalate-induced redistribution of phosphatidylserine (PS) in renal epithelial cell membranes.	Oxalates	155-162	ATP binding cassette subfamily C member 1	Rattus norvegicus	54-95
28577929-1	2017	OBJECTIVE: To investigate the possible involvement of multidrug resistance-associated protein 1 (MRP-1) and breast cancer resistance protein (BCRP) in the oxalate-induced redistribution of phosphatidylserine (PS) in renal epithelial cell membranes.	Oxalates	155-162	ATP binding cassette subfamily C member 1	Rattus norvegicus	97-102
28577929-8	2017	RESULTS: Oxalate produced a concentration-dependent increase in the synthesis of MRP-1 and BCRP.	Oxalates	9-16	ATP binding cassette subfamily C member 1	Rattus norvegicus	81-86
28577929-9	2017	Treatment with MK571 and Ko143 (MRP-1- and BCRP-specific inhibitors, respectively) significantly attenuated the oxalate-induced PS externalization.	Oxalates	112-119	ATP binding cassette subfamily C member 1	Rattus norvegicus	32-37
28577929-12	2017	CONCLUSION: Oxalate induces the upregulation of MRP-1 and BCRP, which act as phospholipid floppases causing PS externalization in the renal epithelial cell membrane.	Oxalates	12-19	ATP binding cassette subfamily C member 1	Rattus norvegicus	48-53
29539912-0	2017	Re: An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria.	Oxalates	76-83	hydroxyacid oxidase 2	Homo sapiens	50-67
28261895-1	2017	Primary hyperoxaluria type 1 (PH1) is a rare liver enzymatic defect that causes overproduction of plasma oxalate.	Oxalates	105-112	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
28261895-2	2017	Accumulation of oxalate in the kidney and subsequent renal failure are fatal to PH1 patients often in pediatric age.	Oxalates	16-23	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	80-83
28916765-1	2017	The alanine:glyoxylate aminotransferase (AGT), a hepatocyte-specific pyridoxal-5"-phosphate (PLP) dependent enzyme, transaminates L-alanine and glyoxylate to glycine and pyruvate, thus detoxifying glyoxylate and preventing pathological oxalate precipitation in tissues.	Oxalates	236-243	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	4-39
28916765-1	2017	The alanine:glyoxylate aminotransferase (AGT), a hepatocyte-specific pyridoxal-5"-phosphate (PLP) dependent enzyme, transaminates L-alanine and glyoxylate to glycine and pyruvate, thus detoxifying glyoxylate and preventing pathological oxalate precipitation in tissues.	Oxalates	236-243	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	41-44
28916765-1	2017	The alanine:glyoxylate aminotransferase (AGT), a hepatocyte-specific pyridoxal-5"-phosphate (PLP) dependent enzyme, transaminates L-alanine and glyoxylate to glycine and pyruvate, thus detoxifying glyoxylate and preventing pathological oxalate precipitation in tissues.	Oxalates	236-243	pyridoxal phosphatase	Homo sapiens	93-96
28435765-11	2017	The institution of a diet low in oxalates resulted in the rapid normalization of urinary oxalate excretion and urinary sediment and in the slow, continuous improvement of renal function to near normal levels (eGFR 59 mL/min/1.73 m2) before his death from a brain malignancy 3.5 years later.	Oxalates	33-41	CD59 molecule (CD59 blood group)	Homo sapiens	220-225
28435765-11	2017	The institution of a diet low in oxalates resulted in the rapid normalization of urinary oxalate excretion and urinary sediment and in the slow, continuous improvement of renal function to near normal levels (eGFR 59 mL/min/1.73 m2) before his death from a brain malignancy 3.5 years later.	Oxalates	33-40	CD59 molecule (CD59 blood group)	Homo sapiens	220-225
27313231-2	2017	Net intestinal absorption of dietary oxalate results from passive paracellular oxalate absorption as modified by oxalate back secretion mediated by the SLC26A6 oxalate transporter.	Oxalates	37-44	solute carrier family 26, member 6	Mus musculus	152-159
27612997-8	2017	We conclude that TNFR signaling is essential for CaOx crystal adhesion to the luminal membrane of renal tubules as a fundamental initiating mechanism of oxalate nephropathy.	Oxalates	153-160	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	17-21
28217701-2	2017	In the genetic disease of Primary Hyperoxaluria Type 1 (PH1), an increased endogenous production of oxalate, due to a deficiency of the liver enzyme alanine-glyoxylate aminotransferase (AGT), results in hyperoxaluria and oxalate kidney stones.	Oxalates	100-107	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	56-59
28217701-2	2017	In the genetic disease of Primary Hyperoxaluria Type 1 (PH1), an increased endogenous production of oxalate, due to a deficiency of the liver enzyme alanine-glyoxylate aminotransferase (AGT), results in hyperoxaluria and oxalate kidney stones.	Oxalates	100-107	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	149-184
28217701-2	2017	In the genetic disease of Primary Hyperoxaluria Type 1 (PH1), an increased endogenous production of oxalate, due to a deficiency of the liver enzyme alanine-glyoxylate aminotransferase (AGT), results in hyperoxaluria and oxalate kidney stones.	Oxalates	100-107	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	186-189
28217701-3	2017	The constant elevation in urinary oxalate in PH1 patients ultimately leads to tissue deposition of oxalate, renal failure and death and the only known cure for PH1 is a liver or liver-kidney transplant.	Oxalates	34-41	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	45-48
28217701-3	2017	The constant elevation in urinary oxalate in PH1 patients ultimately leads to tissue deposition of oxalate, renal failure and death and the only known cure for PH1 is a liver or liver-kidney transplant.	Oxalates	99-106	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	45-48
28674258-8	2017	In human TRPA1 (hTRPA1)-expressing cells, oxaliplatin or oxalate causes TRPA1 sensitization to reactive oxygen species (ROS) by inhibiting prolyl hydroxylases (PHDs).	Oxalates	57-64	transient receptor potential cation channel subfamily A member 1	Homo sapiens	9-14
28674258-8	2017	In human TRPA1 (hTRPA1)-expressing cells, oxaliplatin or oxalate causes TRPA1 sensitization to reactive oxygen species (ROS) by inhibiting prolyl hydroxylases (PHDs).	Oxalates	57-64	transient receptor potential cation channel subfamily A member 1	Homo sapiens	16-22
28674258-8	2017	In human TRPA1 (hTRPA1)-expressing cells, oxaliplatin or oxalate causes TRPA1 sensitization to reactive oxygen species (ROS) by inhibiting prolyl hydroxylases (PHDs).	Oxalates	57-64	transient receptor potential cation channel subfamily A member 1	Homo sapiens	17-22
27313231-3	2017	We used mice deficient in the cystic fibrosis transmembrane conductance regulator gene (Cftr) to test the hypothesis that SLC26A6-mediated oxalate secretion is defective in cystic fibrosis.	Oxalates	139-146	solute carrier family 26, member 6	Mus musculus	122-129
27313231-5	2017	Intestinal tissue isolated from Cftr-/- mice exhibited significantly less transcellular oxalate secretion than intestinal tissue of wild-type mice.	Oxalates	88-95	cystic fibrosis transmembrane conductance regulator	Mus musculus	32-36
27313231-9	2017	In association with the profound defect in intestinal oxalate secretion, Cftr-/- mice had serum and urine oxalate levels 2.5-fold greater than those of wild-type mice.	Oxalates	54-61	cystic fibrosis transmembrane conductance regulator	Mus musculus	73-77
27313231-9	2017	In association with the profound defect in intestinal oxalate secretion, Cftr-/- mice had serum and urine oxalate levels 2.5-fold greater than those of wild-type mice.	Oxalates	106-113	cystic fibrosis transmembrane conductance regulator	Mus musculus	73-77
27681177-1	2016	The brush border Cl--oxalate exchanger SLC26A6 plays an essential role in mediating intestinal secretion of oxalate and is crucial for the maintenance of oxalate homeostasis and the prevention of hyperoxaluria and calcium oxalate nephrolithiasis.	Oxalates	21-28	solute carrier family 26 member 6	Homo sapiens	39-46
28116040-9	2017	In addition, MitoTEMPO altered the protein expression of Nox4 and p22 and decreased the protein expression of IL-6 and osteopontin (OPN) induced by oxalate.	Oxalates	148-155	NADPH oxidase 4	Rattus norvegicus	57-61
28116040-9	2017	In addition, MitoTEMPO altered the protein expression of Nox4 and p22 and decreased the protein expression of IL-6 and osteopontin (OPN) induced by oxalate.	Oxalates	148-155	interleukin 6	Rattus norvegicus	110-114
28116040-9	2017	In addition, MitoTEMPO altered the protein expression of Nox4 and p22 and decreased the protein expression of IL-6 and osteopontin (OPN) induced by oxalate.	Oxalates	148-155	secreted phosphoprotein 1	Rattus norvegicus	119-130
28116040-9	2017	In addition, MitoTEMPO altered the protein expression of Nox4 and p22 and decreased the protein expression of IL-6 and osteopontin (OPN) induced by oxalate.	Oxalates	148-155	secreted phosphoprotein 1	Rattus norvegicus	132-135
27681177-1	2016	The brush border Cl--oxalate exchanger SLC26A6 plays an essential role in mediating intestinal secretion of oxalate and is crucial for the maintenance of oxalate homeostasis and the prevention of hyperoxaluria and calcium oxalate nephrolithiasis.	Oxalates	108-115	solute carrier family 26 member 6	Homo sapiens	39-46
27681177-7	2016	Functional studies of transfected SLC26A6 demonstrated that glycosylation at two sites in the putative second extracellular loop of SLC26A6 is critically important for chloride-dependent oxalate transport and that enzymatic deglycosylation of SLC26A6 expressed on the plasma membrane of intact cells strongly reduced oxalate transport activity.	Oxalates	187-194	solute carrier family 26 member 6	Homo sapiens	34-41
27681177-7	2016	Functional studies of transfected SLC26A6 demonstrated that glycosylation at two sites in the putative second extracellular loop of SLC26A6 is critically important for chloride-dependent oxalate transport and that enzymatic deglycosylation of SLC26A6 expressed on the plasma membrane of intact cells strongly reduced oxalate transport activity.	Oxalates	187-194	solute carrier family 26 member 6	Homo sapiens	132-139
27681177-7	2016	Functional studies of transfected SLC26A6 demonstrated that glycosylation at two sites in the putative second extracellular loop of SLC26A6 is critically important for chloride-dependent oxalate transport and that enzymatic deglycosylation of SLC26A6 expressed on the plasma membrane of intact cells strongly reduced oxalate transport activity.	Oxalates	187-194	solute carrier family 26 member 6	Homo sapiens	132-139
27681177-7	2016	Functional studies of transfected SLC26A6 demonstrated that glycosylation at two sites in the putative second extracellular loop of SLC26A6 is critically important for chloride-dependent oxalate transport and that enzymatic deglycosylation of SLC26A6 expressed on the plasma membrane of intact cells strongly reduced oxalate transport activity.	Oxalates	317-324	solute carrier family 26 member 6	Homo sapiens	34-41
27681177-7	2016	Functional studies of transfected SLC26A6 demonstrated that glycosylation at two sites in the putative second extracellular loop of SLC26A6 is critically important for chloride-dependent oxalate transport and that enzymatic deglycosylation of SLC26A6 expressed on the plasma membrane of intact cells strongly reduced oxalate transport activity.	Oxalates	317-324	solute carrier family 26 member 6	Homo sapiens	132-139
27681177-7	2016	Functional studies of transfected SLC26A6 demonstrated that glycosylation at two sites in the putative second extracellular loop of SLC26A6 is critically important for chloride-dependent oxalate transport and that enzymatic deglycosylation of SLC26A6 expressed on the plasma membrane of intact cells strongly reduced oxalate transport activity.	Oxalates	317-324	solute carrier family 26 member 6	Homo sapiens	132-139
27681177-8	2016	Taken together, these studies indicated that oxalate transport function of SLC26A6 is critically dependent on glycosylation and that exoglycosidase-mediated deglycosylation of SLC26A6 has the capacity to profoundly modulate SLC26A6 function.	Oxalates	45-52	solute carrier family 26 member 6	Homo sapiens	75-82
27681177-8	2016	Taken together, these studies indicated that oxalate transport function of SLC26A6 is critically dependent on glycosylation and that exoglycosidase-mediated deglycosylation of SLC26A6 has the capacity to profoundly modulate SLC26A6 function.	Oxalates	45-52	solute carrier family 26 member 6	Homo sapiens	176-183
27681177-8	2016	Taken together, these studies indicated that oxalate transport function of SLC26A6 is critically dependent on glycosylation and that exoglycosidase-mediated deglycosylation of SLC26A6 has the capacity to profoundly modulate SLC26A6 function.	Oxalates	45-52	solute carrier family 26 member 6	Homo sapiens	176-183
27179589-2	2016	Mutations in peroxisomal alanine:glyoxylate aminotransferase (hAGT1) cause primary hyperoxaluria type 1 (PH1), which results in glyoxylate accumulation that is converted to toxic oxalate.	Oxalates	179-186	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	25-60
27588329-3	2016	We report a study of ET between the Lambda-/Delta-[Co(Ox)3](3-) pair (Ox = oxalate) and horse heart cytochrome c (cyt c).	Oxalates	75-82	cytochrome c, somatic	Equus caballus	100-112
27588329-3	2016	We report a study of ET between the Lambda-/Delta-[Co(Ox)3](3-) pair (Ox = oxalate) and horse heart cytochrome c (cyt c).	Oxalates	75-82	cytochrome c, somatic	Equus caballus	114-119
27847291-4	2016	Our current understanding of endogenous oxalate synthesis indicates that two enzymes, hydroxyproline dehydrogenase and glycolate oxidase (GO), are suitable targets for oxalate reduction therapy.	Oxalates	40-47	hydroxyacid oxidase 2	Homo sapiens	119-136
27847291-4	2016	Our current understanding of endogenous oxalate synthesis indicates that two enzymes, hydroxyproline dehydrogenase and glycolate oxidase (GO), are suitable targets for oxalate reduction therapy.	Oxalates	40-47	hydroxyacid oxidase 2	Homo sapiens	138-140
27847291-4	2016	Our current understanding of endogenous oxalate synthesis indicates that two enzymes, hydroxyproline dehydrogenase and glycolate oxidase (GO), are suitable targets for oxalate reduction therapy.	Oxalates	168-175	hydroxyacid oxidase 2	Homo sapiens	119-136
27847291-4	2016	Our current understanding of endogenous oxalate synthesis indicates that two enzymes, hydroxyproline dehydrogenase and glycolate oxidase (GO), are suitable targets for oxalate reduction therapy.	Oxalates	168-175	hydroxyacid oxidase 2	Homo sapiens	138-140
27718570-0	2016	Alcohols as Latent Coupling Fragments for Metallaphotoredox Catalysis: sp3-sp2 Cross-Coupling of Oxalates with Aryl Halides.	Oxalates	97-105	Sp3 transcription factor	Homo sapiens	71-74
27718570-0	2016	Alcohols as Latent Coupling Fragments for Metallaphotoredox Catalysis: sp3-sp2 Cross-Coupling of Oxalates with Aryl Halides.	Oxalates	97-105	Sp2 transcription factor	Homo sapiens	75-78
27644547-1	2016	Primary hyperoxaluria type 1 (PH1) is a rare genetic disease characterized by excessive oxalate accumulation in plasma and urine, resulting in various phenotypes because of allelic and clinical heterogeneity.	Oxalates	88-95	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
27179589-2	2016	Mutations in peroxisomal alanine:glyoxylate aminotransferase (hAGT1) cause primary hyperoxaluria type 1 (PH1), which results in glyoxylate accumulation that is converted to toxic oxalate.	Oxalates	179-186	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	62-67
27179589-2	2016	Mutations in peroxisomal alanine:glyoxylate aminotransferase (hAGT1) cause primary hyperoxaluria type 1 (PH1), which results in glyoxylate accumulation that is converted to toxic oxalate.	Oxalates	179-186	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	105-108
26812303-1	2016	PURPOSE: SLC26A6 is a multifunctional anion transporter with a critical physiological role in the transport of oxalate anions.	Oxalates	111-118	solute carrier family 26 member 6	Homo sapiens	9-16
27452398-3	2016	Microscopic examination, immunoblotting and immunofluorescence staining revealed that oxalate-treated cells gained mesenchymal phenotypes by fibroblast-like morphological change and increasing expression of vimentin and fibronectin, while levels of epithelial markers (E-cadherin, occludin, cytokeratin and ZO-1) were decreased.	Oxalates	86-93	vimentin	Canis lupus familiaris	207-215
27452398-3	2016	Microscopic examination, immunoblotting and immunofluorescence staining revealed that oxalate-treated cells gained mesenchymal phenotypes by fibroblast-like morphological change and increasing expression of vimentin and fibronectin, while levels of epithelial markers (E-cadherin, occludin, cytokeratin and ZO-1) were decreased.	Oxalates	86-93	fibronectin 1	Canis lupus familiaris	220-231
27452398-3	2016	Microscopic examination, immunoblotting and immunofluorescence staining revealed that oxalate-treated cells gained mesenchymal phenotypes by fibroblast-like morphological change and increasing expression of vimentin and fibronectin, while levels of epithelial markers (E-cadherin, occludin, cytokeratin and ZO-1) were decreased.	Oxalates	86-93	cadherin 1	Canis lupus familiaris	269-279
27452398-3	2016	Microscopic examination, immunoblotting and immunofluorescence staining revealed that oxalate-treated cells gained mesenchymal phenotypes by fibroblast-like morphological change and increasing expression of vimentin and fibronectin, while levels of epithelial markers (E-cadherin, occludin, cytokeratin and ZO-1) were decreased.	Oxalates	86-93	occludin	Canis lupus familiaris	281-289
27452398-3	2016	Microscopic examination, immunoblotting and immunofluorescence staining revealed that oxalate-treated cells gained mesenchymal phenotypes by fibroblast-like morphological change and increasing expression of vimentin and fibronectin, while levels of epithelial markers (E-cadherin, occludin, cytokeratin and ZO-1) were decreased.	Oxalates	86-93	tight junction protein 1	Canis lupus familiaris	307-311
27125215-2	2016	We report here the functional characterization of human SLC26A1, a 4,4"-diisothiocyanato-2,2"-stilbenedisulfonic acid (DIDS)-sensitive, electroneutral sodium-independent anion exchanger transporting sulfate, oxalate, bicarbonate, thiosulfate, and (with divergent properties) chloride.	Oxalates	208-215	solute carrier family 26 member 1	Homo sapiens	56-63
27125215-4	2016	SLC26A1-mediated transport of sulfate and oxalate is highly dependent on allosteric activation by extracellular chloride or non-substrate anions.	Oxalates	42-49	solute carrier family 26 member 1	Homo sapiens	0-7
27191349-7	2016	Oxalate crystals have been shown to activate the NOD-like receptor family, pyrin domain containing 3 inflammasome (also known as NALP3, NLRP3, or cryopyrin), resulting in release of IL-1beta and macrophage infiltration.	Oxalates	0-7	NLR family, pyrin domain containing 3	Mus musculus	129-134
27191349-7	2016	Oxalate crystals have been shown to activate the NOD-like receptor family, pyrin domain containing 3 inflammasome (also known as NALP3, NLRP3, or cryopyrin), resulting in release of IL-1beta and macrophage infiltration.	Oxalates	0-7	NLR family, pyrin domain containing 3	Mus musculus	136-141
27191349-7	2016	Oxalate crystals have been shown to activate the NOD-like receptor family, pyrin domain containing 3 inflammasome (also known as NALP3, NLRP3, or cryopyrin), resulting in release of IL-1beta and macrophage infiltration.	Oxalates	0-7	NLR family, pyrin domain containing 3	Mus musculus	146-155
27191349-7	2016	Oxalate crystals have been shown to activate the NOD-like receptor family, pyrin domain containing 3 inflammasome (also known as NALP3, NLRP3, or cryopyrin), resulting in release of IL-1beta and macrophage infiltration.	Oxalates	0-7	interleukin 1 beta	Mus musculus	182-190
26812303-2	2016	Recognizing a genetic variant of SLC26A6 would advance our understanding of oxalate transport in the formation of calcium oxalate stones.	Oxalates	76-83	solute carrier family 26 member 6	Homo sapiens	33-40
26812303-9	2016	CONCLUSIONS: Our results indicate that the variant G539R in the SLC26A6 gene is associated with kidney stone risk, providing a clear clue to further achieve insight into oxalate transport in kidney stone formation.	Oxalates	170-177	solute carrier family 26 member 6	Homo sapiens	64-71
26943671-7	2016	Samples were processed and the amount of oxalate was measured by ion chromatography, the limit of which is 1.6 muM.	Oxalates	41-48	latexin	Homo sapiens	111-114
26446157-10	2016	VitE group: compared with the positive control group, activity of HK-2 cell, Na(+)/K(+) ATP enzyme was not significantly changed while SOD activity was restored, and MDA content was significantly decreased after the addition of Vit E. Morphological structure of HK-2 cell was extremely changed as observed under TEM after exposure to high level of COM crystals and oxalate.	Oxalates	365-372	vitrin	Homo sapiens	0-3
27096395-1	2016	Primary hyperoxaluria type-3 is characterized by increased oxalate production caused by mutations in the HOGA1 gene encoding 4-hydroxy-2-oxoglutarate aldolase (HOGA1).	Oxalates	59-66	4-hydroxy-2-oxoglutarate aldolase 1	Homo sapiens	105-110
27096395-1	2016	Primary hyperoxaluria type-3 is characterized by increased oxalate production caused by mutations in the HOGA1 gene encoding 4-hydroxy-2-oxoglutarate aldolase (HOGA1).	Oxalates	59-66	4-hydroxy-2-oxoglutarate aldolase 1	Homo sapiens	160-165
27239044-5	2016	Alanine administration reduces histamine levels in wild-type mice, while overexpression of GPT in PH1 mice increases plasma histidine, normalizes histamine levels, restores vascular permeability, and decreases urinary oxalate levels.	Oxalates	218-225	glutamic pyruvic transaminase, soluble	Mus musculus	91-94
27239044-5	2016	Alanine administration reduces histamine levels in wild-type mice, while overexpression of GPT in PH1 mice increases plasma histidine, normalizes histamine levels, restores vascular permeability, and decreases urinary oxalate levels.	Oxalates	218-225	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	98-101
26854734-0	2016	Effects of alanine:glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assay.	Oxalates	86-93	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	11-46
26854734-5	2016	Co-expression of normal AGTs and some, but not all, mutant AGT variants partially counteracted this cytotoxicity and led to decreased synthesis of oxalate and glyoxylate.	Oxalates	147-154	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	24-27
26854734-7	2016	The increased survival seen with AGT-Gly170Arg was paralleled by a 40% decrease in oxalate and glyoxylate levels.	Oxalates	83-90	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	33-36
26689264-5	2016	Next, we produced double KO mice (Agxt1(-/-) Hao1(-/-)) that showed low levels of oxalate excretion compared with hyperoxaluric mice model (Agxt1(-/-)).	Oxalates	82-89	alanine-glyoxylate aminotransferase	Mus musculus	34-39
27014926-8	2016	A 2.6 A resolution X-ray crystal structure of a complex between oxalate and the Co(II)-substituted DeltaE162 OxDC variant, in which Glu(162) has been deleted from the active site loop, reveals the likely mode by which the substrate coordinates the catalytically active Mn ion prior to C-C bond cleavage.	Oxalates	64-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
26560472-1	2016	OBJECTIVES: We investigated the possible involvement of multidrug resistance protein 1 P-glycoprotein (MDR1 P-gp) in the oxalate-induced redistribution of phosphatidylserine in renal epithelial cell membranes.	Oxalates	121-128	ATP binding cassette subfamily B member 1	Canis lupus familiaris	103-107
26484935-6	2016	It is likely that there is a high enough oxalate to copper(II) ion ratio in many types of atmospheric aerosols to decrease the HO2 uptake coefficient.	Oxalates	41-48	heme oxygenase 2	Homo sapiens	127-130
26900946-4	2016	AAE3 has been proposed to catalyze the first step in an alternative pathway of oxalate degradation.	Oxalates	79-86	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	0-4
26900946-6	2016	Here, we identify the Medicago truncatula AAE3 (MtAAE3) and show that it encodes an oxalyl-CoA synthetase activity exhibiting high activity against oxalate with a Km = 81 +- 9 muM and Vmax = 19 +- 0.9 mumoles min-1mg protein-1.	Oxalates	148-155	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	42-46
26900946-10	2016	Taken together, these results suggest that AAE3 dependent turnover of oxalate is important to different plants and functions in the regulation of tissue calcium oxalate crystal accumulation and in defense against oxalate-secreting phytopathogens.	Oxalates	70-77	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	43-47
26900946-10	2016	Taken together, these results suggest that AAE3 dependent turnover of oxalate is important to different plants and functions in the regulation of tissue calcium oxalate crystal accumulation and in defense against oxalate-secreting phytopathogens.	Oxalates	161-168	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	43-47
26560472-1	2016	OBJECTIVES: We investigated the possible involvement of multidrug resistance protein 1 P-glycoprotein (MDR1 P-gp) in the oxalate-induced redistribution of phosphatidylserine in renal epithelial cell membranes.	Oxalates	121-128	PGP	Canis lupus familiaris	108-112
26560472-3	2016	RESULTS: Oxalate treatment resulted in increased synthesis of MDR1, which resulted in phosphatidylserine (PS) externalization in the renal epithelial cell membrane.	Oxalates	9-16	ATP binding cassette subfamily B member 1	Canis lupus familiaris	62-66
26560472-6	2016	CONCLUSIONS: To our knowledge, this study is the first to show that oxalate increases the synthesis of MDR1 P-gp, which plays a key role in hyperoxaluria-promoted calcium oxalate urolithiasis by facilitating phosphatidylserine redistribution in renal epithelial cells.	Oxalates	68-75	ATP binding cassette subfamily B member 1	Canis lupus familiaris	103-107
26560472-6	2016	CONCLUSIONS: To our knowledge, this study is the first to show that oxalate increases the synthesis of MDR1 P-gp, which plays a key role in hyperoxaluria-promoted calcium oxalate urolithiasis by facilitating phosphatidylserine redistribution in renal epithelial cells.	Oxalates	68-75	PGP	Canis lupus familiaris	108-112
26671348-0	2016	Enhancing the carbon capture capacities of a rigid ultra-microporous MOF through gate-opening at low CO2 pressures assisted by swiveling oxalate pillars.	Oxalates	137-144	lysine acetyltransferase 8	Homo sapiens	69-72
26538444-0	2016	Sulfate and thiosulfate inhibit oxalate transport via a dPrestin (Slc26a6)-dependent mechanism in an insect model of calcium oxalate nephrolithiasis.	Oxalates	32-39	prestin	Drosophila melanogaster	56-64
26538444-8	2016	Furthermore, thiosulfate has a higher affinity for dPrestin and mSlc26a6 compared with oxalate These data indicate that thiosulfate"s ability to act as a competitive inhibitor of oxalate via dPrestin, can explain the decrease in CaOx crystallization seen in the presence of thiosulfate, but not sulfate.	Oxalates	87-94	prestin	Drosophila melanogaster	191-199
26538444-8	2016	Furthermore, thiosulfate has a higher affinity for dPrestin and mSlc26a6 compared with oxalate These data indicate that thiosulfate"s ability to act as a competitive inhibitor of oxalate via dPrestin, can explain the decrease in CaOx crystallization seen in the presence of thiosulfate, but not sulfate.	Oxalates	179-186	prestin	Drosophila melanogaster	51-59
26538444-8	2016	Furthermore, thiosulfate has a higher affinity for dPrestin and mSlc26a6 compared with oxalate These data indicate that thiosulfate"s ability to act as a competitive inhibitor of oxalate via dPrestin, can explain the decrease in CaOx crystallization seen in the presence of thiosulfate, but not sulfate.	Oxalates	179-186	prestin	Drosophila melanogaster	191-199
26418869-8	2015	The U12 motif is stabilized by benzoate, oxalates, and glycolate ligands.	Oxalates	41-49	RNA, U12 small nuclear 2, pseudogene	Homo sapiens	4-7
26162424-2	2015	In this report, we re-examine our prior work on the effects of a metabolic acidosis on urinary oxalate handling [Green et al., Am J Physiol Ren Physiol 289(3):F536-F543, 2005], offering a more detailed analysis and interpretation of the data, together with new, previously unpublished observations revealing a marked impact on intestinal oxalate transport.	Oxalates	95-102	renin	Rattus norvegicus	140-143
25697095-3	2015	Proline dehydrogenase 2 (PRODH2), historically known as hydroxyproline oxidase, is the first step in the hydroxyproline catabolic pathway and represents a drug target to reduce the glyoxylate and oxalate burden of PH patients.	Oxalates	196-203	proline dehydrogenase 2	Homo sapiens	0-23
26493452-9	2015	Moreover, it was established that oxalate induces proliferation of breast cells and stimulates the expression of a pro-tumorigenic gene c-fos.	Oxalates	34-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-141
26493452-12	2015	CONCLUSIONS: We found that the chronic exposure of breast epithelial cells to oxalate promotes the transformation of breast cells from normal to tumor cells, inducing the expression of a proto-oncogen as c-fos and proliferation in breast cancer cells.	Oxalates	78-85	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	204-209
26526882-4	2015	Expression of sat-1 and rate-limiting enzymes of oxalate synthesis, alcohol dehydrogenase 1 (Adh1) and hydroxy-acid oxidase 1 (Hao1), was determined by immunocytochemistry (protein) and/or real time reverse transcription polymerase chain reaction (mRNA).	Oxalates	49-56	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	14-19
26526882-4	2015	Expression of sat-1 and rate-limiting enzymes of oxalate synthesis, alcohol dehydrogenase 1 (Adh1) and hydroxy-acid oxidase 1 (Hao1), was determined by immunocytochemistry (protein) and/or real time reverse transcription polymerase chain reaction (mRNA).	Oxalates	49-56	alcohol dehydrogenase 1C (class I), gamma polypeptide	Rattus norvegicus	68-91
26110967-4	2015	Complex 5 reacts smoothly with CO2 to generate the bridging oxalate complex [(TiX3 )2 (mu2 -C2 O4 -kappaO:kappaO"")], 6, in a C-C bond formation reaction commonly anticipated for oxalate formation by reductive coupling of CO2 on low-valent transition-metal complexes.	Oxalates	60-67	adaptor related protein complex 1 subunit mu 2	Homo sapiens	87-90
26110967-4	2015	Complex 5 reacts smoothly with CO2 to generate the bridging oxalate complex [(TiX3 )2 (mu2 -C2 O4 -kappaO:kappaO"")], 6, in a C-C bond formation reaction commonly anticipated for oxalate formation by reductive coupling of CO2 on low-valent transition-metal complexes.	Oxalates	179-186	adaptor related protein complex 1 subunit mu 2	Homo sapiens	87-90
25677624-2	2015	We expressed an azalea GLP (RmGLP2) in cultured cells of tobacco, and determined that the extracellular protein fraction and the recombinant RmGLP2 protein purified from these cells catalyzed the oxidation of oxalate.	Oxalates	209-216	auxin-binding protein ABP19a-like	Nicotiana tabacum	23-26
25697095-3	2015	Proline dehydrogenase 2 (PRODH2), historically known as hydroxyproline oxidase, is the first step in the hydroxyproline catabolic pathway and represents a drug target to reduce the glyoxylate and oxalate burden of PH patients.	Oxalates	196-203	proline dehydrogenase 2	Homo sapiens	25-31
25197769-1	2014	Proton conductivity through two-dimensional (2-D) hydrogen-bonding networks within a layered metal-organic framework (MOF) (NH4)2(H2adp)[Zn2(ox)3] 3H2O (H2adp = adipic acid; ox = oxalate) has been successfully controlled by cation substitution.	Oxalates	179-186	lysine acetyltransferase 8	Homo sapiens	93-122
25664730-5	2015	Further, an apo LDHA crystal structure solved in a new space group is reported, as well as a complex with both NADH and the substrate analogue oxalate bound in seven of the eight molecules and an oxalate only bound in the eighth molecule in the asymmetric unit.	Oxalates	143-150	lactate dehydrogenase A	Homo sapiens	16-20
25664730-5	2015	Further, an apo LDHA crystal structure solved in a new space group is reported, as well as a complex with both NADH and the substrate analogue oxalate bound in seven of the eight molecules and an oxalate only bound in the eighth molecule in the asymmetric unit.	Oxalates	196-203	lactate dehydrogenase A	Homo sapiens	16-20
25237136-4	2014	Although AGT(P11LG170R) is functional, the enzyme must be in the peroxisome to detoxify glyoxylate by conversion to alanine; in disease, amassed glyoxylate in the peroxisome is transported to the cytosol and converted to oxalate by lactate dehydrogenase, leading to kidney failure.	Oxalates	221-228	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	9-12
25182965-1	2014	Theoretical mechanistic calculations (DFT) on the reactivity of [{((Dip)Nacnac)Mg}2] ((Dip)Nacnac = [(DipNCMe)2CH](-), Dip = C6H3(i)Pr2-2,6) towards CO2 were carried out in order to rationalise the experimental formation of a carbonate (major product) and an oxalate (minor product).	Oxalates	259-266	DIP	Homo sapiens	68-71
25182965-1	2014	Theoretical mechanistic calculations (DFT) on the reactivity of [{((Dip)Nacnac)Mg}2] ((Dip)Nacnac = [(DipNCMe)2CH](-), Dip = C6H3(i)Pr2-2,6) towards CO2 were carried out in order to rationalise the experimental formation of a carbonate (major product) and an oxalate (minor product).	Oxalates	259-266	DIP	Homo sapiens	87-90
25182965-1	2014	Theoretical mechanistic calculations (DFT) on the reactivity of [{((Dip)Nacnac)Mg}2] ((Dip)Nacnac = [(DipNCMe)2CH](-), Dip = C6H3(i)Pr2-2,6) towards CO2 were carried out in order to rationalise the experimental formation of a carbonate (major product) and an oxalate (minor product).	Oxalates	259-266	DIP	Homo sapiens	87-90
24956378-0	2014	Androgen receptor enhances kidney stone-CaOx crystal formation via modulation of oxalate biosynthesis & oxidative stress.	Oxalates	81-88	androgen receptor	Mus musculus	0-17
24956378-5	2014	Targeting AR with the AR degradation enhancer ASC-J9 led to suppression of CaOx crystal formation via modulation of oxalate biosynthesis and oxidative stress in both in vitro and in vivo studies.	Oxalates	116-123	androgen receptor	Mus musculus	10-12
24956378-5	2014	Targeting AR with the AR degradation enhancer ASC-J9 led to suppression of CaOx crystal formation via modulation of oxalate biosynthesis and oxidative stress in both in vitro and in vivo studies.	Oxalates	116-123	androgen receptor	Mus musculus	22-24
24678692-6	2014	Fe(III) complex photolysis is an important additional sink for tartronate, pyruvate, and oxalate, with a complex photolysis contribution to overall degradation of 46, 40, and 99%, respectively, compared to all possible sink reactions with atmospheric aqueous-phase radicals, such as ( )OH, NO3( ), and SO4( ) (-).	Oxalates	89-96	NBL1, DAN family BMP antagonist	Homo sapiens	290-293
24460843-8	2014	Exposure of LLC-PK1 cells to oxalate resulted in increased levels of H2 O2 and lipid hydroperoxide, correlating with increased release of cell injury markers, including LDH, alkaline phosphate, and gamma-glutamyl transpeptidase from renal tubular epithelial cells.	Oxalates	29-36	glutathione hydrolase 1 proenzyme	Sus scrofa	198-227
24797341-1	2014	Combined liver kidney transplant is the preferred transplant option for most patients with primary hyperoxaluria type 1 (PH1) given that it removes the hepatic source of oxalate production and improves renal allograft survival.	Oxalates	170-177	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	121-124
24797341-2	2014	However, PH1 patients homozygous for the G170R mutation can develop normal urine oxalate levels with pyridoxine therapy and may be candidates for kidney alone transplant (KTx).	Oxalates	81-88	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	9-12
24523387-0	2014	Oxalate upregulates expression of IL-2Rbeta and activates IL-2R signaling in HK-2 cells, a line of human renal epithelial cells.	Oxalates	0-7	interleukin 2 receptor subunit beta	Homo sapiens	34-43
24523387-0	2014	Oxalate upregulates expression of IL-2Rbeta and activates IL-2R signaling in HK-2 cells, a line of human renal epithelial cells.	Oxalates	0-7	interleukin 2 receptor subunit alpha	Homo sapiens	34-39
24523387-2	2014	Our gene expression study indicated an increase in interleukin-2 receptor beta (IL-2Rbeta) mRNA in response to oxalate (Koul S, Khandrika L, Meacham RB, Koul HK.	Oxalates	111-118	interleukin 2 receptor subunit beta	Homo sapiens	51-78
24523387-2	2014	Our gene expression study indicated an increase in interleukin-2 receptor beta (IL-2Rbeta) mRNA in response to oxalate (Koul S, Khandrika L, Meacham RB, Koul HK.	Oxalates	111-118	interleukin 2 receptor subunit beta	Homo sapiens	80-89
24523387-4	2014	Herein, we evaluated IL-2Rbeta expression and its downstream signaling pathway in HK-2 cells in an effort to understand the mechanisms of oxalate nephrotoxicity.	Oxalates	138-145	interleukin 2 receptor subunit beta	Homo sapiens	21-30
24523387-8	2014	Exposure of HK-2 cells to oxalate resulted in increased transcription of IL-2Rbeta mRNA and increased protein levels.	Oxalates	26-33	interleukin 2 receptor subunit beta	Homo sapiens	73-82
24523387-9	2014	Oxalate treatment also activated the IL-2Rbeta signaling pathway (JAK1/STAT5 phosphorylation).	Oxalates	0-7	interleukin 2 receptor subunit beta	Homo sapiens	37-46
24523387-9	2014	Oxalate treatment also activated the IL-2Rbeta signaling pathway (JAK1/STAT5 phosphorylation).	Oxalates	0-7	Janus kinase 1	Homo sapiens	66-70
24523387-9	2014	Oxalate treatment also activated the IL-2Rbeta signaling pathway (JAK1/STAT5 phosphorylation).	Oxalates	0-7	signal transducer and activator of transcription 5A	Homo sapiens	71-76
24523387-11	2014	These results suggest that oxalate-induced activation of the IL-2Rbeta pathway may lead to a plethora of cellular changes, the most common of which is the induction of inflammation.	Oxalates	27-34	interleukin 2 receptor subunit beta	Homo sapiens	61-70
24523387-12	2014	These results suggest a central role for the p38 MAPK pathway in mediating the effects of oxalate in renal cells, and additional studies may provide the key to unlocking novel biochemical targets in stone disease.	Oxalates	90-97	mitogen-activated protein kinase 14	Homo sapiens	45-48
24089413-5	2013	Plasma oxalate was elevated in all PH1 patients and inverse to creatinine clearance.	Oxalates	7-14	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	35-38
23475213-3	2014	We determined the effect of renal epithelial exposure to oxalate (Ox), calcium oxalate (CaOx) monohydrate (COM) or hydroxyapatite (HA) crystal on the expression of MGP.	Oxalates	57-64	matrix Gla protein	Rattus norvegicus	164-167
24628885-12	2014	CONCLUSION: Together, these results suggest that THP and OPN are both involved in the pathogenesis and response to oxalate exposure.	Oxalates	115-122	uromodulin	Canis lupus familiaris	49-52
24628885-12	2014	CONCLUSION: Together, these results suggest that THP and OPN are both involved in the pathogenesis and response to oxalate exposure.	Oxalates	115-122	secreted phosphoprotein 1	Canis lupus familiaris	57-60
24597142-4	2014	The innovation in antilithiatic proteins is that they are anionic, rich in acidic amino acids which make oxalate unavailable by interacting with calcium and have EF Hand domain which is a characteristic feature of various calcium binding protein like calgranulin, osteopontin.	Oxalates	105-112	secreted phosphoprotein 1	Homo sapiens	264-275
24388242-5	2014	The limits of detection were 0.4, 0.6 and 1.3muM and limits of quantitation 1.3, 1.9 and 4.2muM for oxalate, formate and glycolate, respectively.	Oxalates	100-107	latexin	Homo sapiens	92-95
24089413-6	2013	Renal secretion of oxalate was present in all PH1 but rare in controls.	Oxalates	19-26	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	46-49
23959075-5	2013	In addition, we determined whether HC-1 colonization led to reductions in urinary oxalate excretion in these mice.	Oxalates	82-89	heterochromatin, Chr 1	Mus musculus	35-39
23494551-1	2013	Primary hyperoxaluria type 1 (PH1) is a rare inborn error of glyoxylate metabolism of autosomal recessive inheritance, leading to progressive systemic oxalate storage (named "oxalosis") with a high rate of morbidity and mortality, as well as an unacceptable quality of life for most patients.	Oxalates	151-158	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	0-28
23494551-1	2013	Primary hyperoxaluria type 1 (PH1) is a rare inborn error of glyoxylate metabolism of autosomal recessive inheritance, leading to progressive systemic oxalate storage (named "oxalosis") with a high rate of morbidity and mortality, as well as an unacceptable quality of life for most patients.	Oxalates	151-158	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
23886857-0	2013	Transcellular oxalate and Cl- absorption in mouse intestine is mediated by the DRA anion exchanger Slc26a3, and DRA deletion decreases urinary oxalate.	Oxalates	14-21	solute carrier family 26, member 3	Mus musculus	79-82
23886857-0	2013	Transcellular oxalate and Cl- absorption in mouse intestine is mediated by the DRA anion exchanger Slc26a3, and DRA deletion decreases urinary oxalate.	Oxalates	14-21	solute carrier family 26, member 3	Mus musculus	99-106
23886857-0	2013	Transcellular oxalate and Cl- absorption in mouse intestine is mediated by the DRA anion exchanger Slc26a3, and DRA deletion decreases urinary oxalate.	Oxalates	143-150	solute carrier family 26, member 3	Mus musculus	112-115
23886857-3	2013	Mouse Slc26a6 (PAT1) targets to the apical membrane of enterocytes in the small intestine, and its deletion results in net oxalate absorption and hyperoxaluria.	Oxalates	123-130	solute carrier family 26, member 6	Mus musculus	6-13
23886857-3	2013	Mouse Slc26a6 (PAT1) targets to the apical membrane of enterocytes in the small intestine, and its deletion results in net oxalate absorption and hyperoxaluria.	Oxalates	123-130	solute carrier family 26, member 6	Mus musculus	15-19
23886857-4	2013	Apical exchangers of the Slc26a family that mediate oxalate absorption have not been established, yet the Slc26a3 [downregulated in adenoma (DRA)] protein is a candidate mediator of oxalate uptake.	Oxalates	182-189	solute carrier family 26, member 3	Mus musculus	106-113
23886857-4	2013	Apical exchangers of the Slc26a family that mediate oxalate absorption have not been established, yet the Slc26a3 [downregulated in adenoma (DRA)] protein is a candidate mediator of oxalate uptake.	Oxalates	182-189	solute carrier family 26, member 3	Mus musculus	141-144
23886857-5	2013	We evaluated the role of DRA in intestinal oxalate and Cl(-) transport by comparing unidirectional and net ion fluxes across short-circuited segments of small (ileum) and large (cecum and distal colon) intestine from wild-type (WT) and DRA knockout (KO) mice.	Oxalates	43-50	solute carrier family 26, member 3	Mus musculus	25-28
23886857-9	2013	We conclude that DRA mediates a predominance of the apical uptake of oxalate and Cl(-) absorbed in the small and large intestine of mice under short-circuit conditions.	Oxalates	69-76	solute carrier family 26, member 3	Mus musculus	17-20
23933580-10	2013	CONCLUSION: We demonstrate that cardiac myocytes express different isoforms of Slc26a6, which encode electrogenic Cl(-)/HCO3(-) and Cl(-)/oxalate exchangers.	Oxalates	138-145	solute carrier family 26, member 6	Mus musculus	79-86
24152109-0	2013	Human serum transferrin: is there a link among autism, high oxalate levels, and iron deficiency anemia?	Oxalates	60-67	transferrin	Homo sapiens	12-23
24152109-1	2013	It has been previously suggested that large amounts of oxalate in plasma could play a role in autism by binding to the bilobal iron transport protein transferrin (hTF), thereby interfering with iron metabolism by inhibiting the delivery of iron to cells.	Oxalates	55-62	transferrin	Homo sapiens	150-161
23739234-0	2013	NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy.	Oxalates	81-88	NLR family, pyrin domain containing 3	Mus musculus	0-5
23739234-6	2013	Mice fed the diet high in soluble oxalate demonstrated increased NALP3 expression in the kidney.	Oxalates	34-41	NLR family, pyrin domain containing 3	Mus musculus	65-70
23739234-7	2013	Nalp3-null mice were completely protected from the progressive renal failure and death that occurred in wild-type mice fed the diet high in soluble oxalate.	Oxalates	148-155	NLR family, pyrin domain containing 3	Mus musculus	0-5
23915277-1	2013	Type 1 primary hyperoxaluria (PH1) causes renal failure, for which isolated kidney transplantation (KT) is usually unsuccessful treatment due to early oxalate stone recurrence.	Oxalates	151-158	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
23915277-9	2013	We conclude that persistently elevated oxalate levels after combined APLT-KT for PH1 treatment, results from inadequate relative functional capacity.	Oxalates	39-46	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	81-84
23833257-0	2013	SLC26A6 and NaDC-1 transporters interact to regulate oxalate and citrate homeostasis.	Oxalates	53-60	solute carrier family 26, member 6	Mus musculus	0-7
23833257-0	2013	SLC26A6 and NaDC-1 transporters interact to regulate oxalate and citrate homeostasis.	Oxalates	53-60	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	Mus musculus	12-18
23833257-2	2013	Here, we examined the relationship between the oxalate transporter SLC26A6 and the citrate transporter NaDC-1 in citrate and oxalate homeostasis.	Oxalates	47-54	solute carrier family 26, member 6	Mus musculus	67-74
23833257-2	2013	Here, we examined the relationship between the oxalate transporter SLC26A6 and the citrate transporter NaDC-1 in citrate and oxalate homeostasis.	Oxalates	47-54	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	Mus musculus	103-109
23596171-0	2013	Extracellular nucleotides inhibit oxalate transport by human intestinal Caco-2-BBe cells through PKC-delta activation.	Oxalates	34-41	protein kinase C delta	Homo sapiens	97-106
24029263-1	2013	Primary hyperoxaluria type-1 (PH-1) is a rare autosomal recessive metabolic disorder leading to excessive oxalate production, deposition of calcium oxalate crystals in the kidney, nephrocalcinosis, progressive renal failure and systemic deposition of oxalate (oxalosis).	Oxalates	106-113	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	0-28
24029263-1	2013	Primary hyperoxaluria type-1 (PH-1) is a rare autosomal recessive metabolic disorder leading to excessive oxalate production, deposition of calcium oxalate crystals in the kidney, nephrocalcinosis, progressive renal failure and systemic deposition of oxalate (oxalosis).	Oxalates	106-113	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-34
24029263-1	2013	Primary hyperoxaluria type-1 (PH-1) is a rare autosomal recessive metabolic disorder leading to excessive oxalate production, deposition of calcium oxalate crystals in the kidney, nephrocalcinosis, progressive renal failure and systemic deposition of oxalate (oxalosis).	Oxalates	148-155	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	0-28
24029263-1	2013	Primary hyperoxaluria type-1 (PH-1) is a rare autosomal recessive metabolic disorder leading to excessive oxalate production, deposition of calcium oxalate crystals in the kidney, nephrocalcinosis, progressive renal failure and systemic deposition of oxalate (oxalosis).	Oxalates	148-155	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-34
23596171-3	2013	Intestinal oxalate secretion mediated by the anion exchanger SLC26A6 plays an essential role in preventing hyperoxaluria and calcium oxalate nephrolithiasis, indicating that understanding the mechanisms regulating intestinal oxalate transport is critical for management of hyperoxaluria.	Oxalates	11-18	solute carrier family 26 member 6	Homo sapiens	61-68
23596171-6	2013	We measured [14C]oxalate uptake in the presence of an outward Cl- gradient as an assay of Cl-/oxalate exchange activity, >=50% of which is mediated by SLC26A6.	Oxalates	17-24	solute carrier family 26 member 6	Homo sapiens	154-161
23596171-6	2013	We measured [14C]oxalate uptake in the presence of an outward Cl- gradient as an assay of Cl-/oxalate exchange activity, >=50% of which is mediated by SLC26A6.	Oxalates	94-101	solute carrier family 26 member 6	Homo sapiens	154-161
23596171-7	2013	We found that ATP and UTP significantly inhibited oxalate transport by C2 cells, an effect blocked by the PKC inhibitor Go-6983.	Oxalates	50-57	protein kinase C delta	Homo sapiens	106-109
23596171-8	2013	Utilizing pharmacological agonists and antagonists, as well as PKC-delta knockdown studies, we observed that ATP inhibits oxalate transport through the P2Y2 receptor, PLC, and PKC-delta.	Oxalates	122-129	protein kinase C delta	Homo sapiens	63-72
23596171-8	2013	Utilizing pharmacological agonists and antagonists, as well as PKC-delta knockdown studies, we observed that ATP inhibits oxalate transport through the P2Y2 receptor, PLC, and PKC-delta.	Oxalates	122-129	protein kinase C delta	Homo sapiens	176-185
23596171-9	2013	Biotinylation studies showed that ATP inhibits oxalate transport by lowering SLC26A6 surface expression.	Oxalates	47-54	solute carrier family 26 member 6	Homo sapiens	77-84
23596171-11	2013	We conclude that ATP and UTP inhibit oxalate transport by lowering SLC26A6 surface expression in C2 cells through signaling pathways including the P2Y2 purinergic receptor, PLC, and PKC-delta.	Oxalates	37-44	solute carrier family 26 member 6	Homo sapiens	67-74
23596171-11	2013	We conclude that ATP and UTP inhibit oxalate transport by lowering SLC26A6 surface expression in C2 cells through signaling pathways including the P2Y2 purinergic receptor, PLC, and PKC-delta.	Oxalates	37-44	protein kinase C delta	Homo sapiens	182-191
23324180-6	2013	In contrast to the behavior of NBCe1-like activity in renal preparations, we find that cloned NBCe1-A is only slightly stimulated by Li(+), not at all influenced by sulfite or oxalate, and only weakly inhibited by harmaline.	Oxalates	176-183	solute carrier family 4 member 4	Homo sapiens	94-101
23599041-7	2013	Given that oxalate is a degradation product of vitamin C and hGR/HPR acts to limit cellular oxalate levels, this association physically couples two independent regulators of cellular oxalate production.	Oxalates	11-18	haptoglobin-related protein	Homo sapiens	65-68
23599041-7	2013	Given that oxalate is a degradation product of vitamin C and hGR/HPR acts to limit cellular oxalate levels, this association physically couples two independent regulators of cellular oxalate production.	Oxalates	92-99	haptoglobin-related protein	Homo sapiens	65-68
23599041-7	2013	Given that oxalate is a degradation product of vitamin C and hGR/HPR acts to limit cellular oxalate levels, this association physically couples two independent regulators of cellular oxalate production.	Oxalates	92-99	haptoglobin-related protein	Homo sapiens	65-68
23595894-9	2013	Although a positive correlation with cytokine expression density and 24 h-urinary oxalate expression (mg oxalate/mg creatinine) has been assessed with TNF (p = 0.04, r = 0.82), FAS (p = 0.05, r = 0.80), FAS-L (p = 0.04, r = 0.82); no correlation could be demonstrated between TRAIL and TRAIL R2 expressions.	Oxalates	82-89	tumor necrosis factor-like	Rattus norvegicus	151-154
23595894-9	2013	Although a positive correlation with cytokine expression density and 24 h-urinary oxalate expression (mg oxalate/mg creatinine) has been assessed with TNF (p = 0.04, r = 0.82), FAS (p = 0.05, r = 0.80), FAS-L (p = 0.04, r = 0.82); no correlation could be demonstrated between TRAIL and TRAIL R2 expressions.	Oxalates	82-89	Fas ligand	Rattus norvegicus	203-208
23595894-9	2013	Although a positive correlation with cytokine expression density and 24 h-urinary oxalate expression (mg oxalate/mg creatinine) has been assessed with TNF (p = 0.04, r = 0.82), FAS (p = 0.05, r = 0.80), FAS-L (p = 0.04, r = 0.82); no correlation could be demonstrated between TRAIL and TRAIL R2 expressions.	Oxalates	82-89	TNF superfamily member 10	Rattus norvegicus	276-281
23595894-9	2013	Although a positive correlation with cytokine expression density and 24 h-urinary oxalate expression (mg oxalate/mg creatinine) has been assessed with TNF (p = 0.04, r = 0.82), FAS (p = 0.05, r = 0.80), FAS-L (p = 0.04, r = 0.82); no correlation could be demonstrated between TRAIL and TRAIL R2 expressions.	Oxalates	82-89	TNF superfamily member 10	Rattus norvegicus	286-291
23595894-9	2013	Although a positive correlation with cytokine expression density and 24 h-urinary oxalate expression (mg oxalate/mg creatinine) has been assessed with TNF (p = 0.04, r = 0.82), FAS (p = 0.05, r = 0.80), FAS-L (p = 0.04, r = 0.82); no correlation could be demonstrated between TRAIL and TRAIL R2 expressions.	Oxalates	105-112	tumor necrosis factor-like	Rattus norvegicus	151-154
23595894-10	2013	Our results indicate that apoptosis induced by oxalate is possibly mediated via TNF and FAS pathways.	Oxalates	47-54	tumor necrosis factor-like	Rattus norvegicus	80-83
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Oxalates	69-76	transferrin	Homo sapiens	38-40
23352899-0	2013	Cellular adaptive response of distal renal tubular cells to high-oxalate environment highlights surface alpha-enolase as the enhancer of calcium oxalate monohydrate crystal adhesion.	Oxalates	65-72	enolase 1	Homo sapiens	104-117
23352899-5	2013	The oxalate-induced up-regulation of alpha-enolase in whole cell lysate was confirmed by 2-D Western blot analysis.	Oxalates	4-11	enolase 1	Homo sapiens	37-50
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Oxalates	69-76	transferrin	Homo sapiens	62-64
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Oxalates	69-76	transferrin	Homo sapiens	62-64
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Oxalates	69-76	transferrin	Homo sapiens	62-64
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Oxalates	69-76	transferrin	Homo sapiens	62-64
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Oxalates	69-76	transferrin	Homo sapiens	62-64
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Oxalates	219-226	transferrin	Homo sapiens	38-40
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Oxalates	219-226	transferrin	Homo sapiens	62-64
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Oxalates	219-226	transferrin	Homo sapiens	62-64
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Oxalates	219-226	transferrin	Homo sapiens	62-64
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Oxalates	219-226	transferrin	Homo sapiens	62-64
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Oxalates	219-226	transferrin	Homo sapiens	62-64
24145091-6	2013	Furthermore, western blotting showed that resveratrol downregulated the expression of MCP-1-related proteins including transforming growth factor(TGF-beta1), TGFR-I or II and hyaluronan in oxalate-treated HRCs.	Oxalates	189-196	C-C motif chemokine ligand 2	Rattus norvegicus	86-91
24145091-6	2013	Furthermore, western blotting showed that resveratrol downregulated the expression of MCP-1-related proteins including transforming growth factor(TGF-beta1), TGFR-I or II and hyaluronan in oxalate-treated HRCs.	Oxalates	189-196	transforming growth factor, beta 1	Rattus norvegicus	146-155
24145091-7	2013	Consistently, resveratrol reduced oxalate-mediated production of reactive oxygen species (ROS) and malondialdehyde (MDA) in oxalate-treated HRCs, while the activities of anti-oxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were enhanced by resveratrol in HRCs and EG-treated kidneys of rats.	Oxalates	34-41	catalase	Rattus norvegicus	227-235
24145091-7	2013	Consistently, resveratrol reduced oxalate-mediated production of reactive oxygen species (ROS) and malondialdehyde (MDA) in oxalate-treated HRCs, while the activities of anti-oxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were enhanced by resveratrol in HRCs and EG-treated kidneys of rats.	Oxalates	34-41	catalase	Rattus norvegicus	237-240
24145091-7	2013	Consistently, resveratrol reduced oxalate-mediated production of reactive oxygen species (ROS) and malondialdehyde (MDA) in oxalate-treated HRCs, while the activities of anti-oxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were enhanced by resveratrol in HRCs and EG-treated kidneys of rats.	Oxalates	124-131	catalase	Rattus norvegicus	227-235
24145091-7	2013	Consistently, resveratrol reduced oxalate-mediated production of reactive oxygen species (ROS) and malondialdehyde (MDA) in oxalate-treated HRCs, while the activities of anti-oxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were enhanced by resveratrol in HRCs and EG-treated kidneys of rats.	Oxalates	124-131	catalase	Rattus norvegicus	237-240
22836206-4	2012	Under optimal conditions, the calibration curve of oxalate was linear between 3.0-50.0 mg L-1, with a limit of detection of 1.0 mg L-1.	Oxalates	51-58	immunoglobulin kappa variable 1-16	Homo sapiens	90-93
22573180-2	2012	Sulfate anion transporter 1 (SAT1, Slc26a1) is considered to be a major basolateral anion-oxalate exchanger in the proximal tubule and we hypothesized its expression may correlate with urinary oxalate excretion.	Oxalates	90-97	solute carrier family 26 member 1	Rattus norvegicus	0-27
22573180-2	2012	Sulfate anion transporter 1 (SAT1, Slc26a1) is considered to be a major basolateral anion-oxalate exchanger in the proximal tubule and we hypothesized its expression may correlate with urinary oxalate excretion.	Oxalates	90-97	solute carrier family 26 member 1	Rattus norvegicus	29-33
22573180-2	2012	Sulfate anion transporter 1 (SAT1, Slc26a1) is considered to be a major basolateral anion-oxalate exchanger in the proximal tubule and we hypothesized its expression may correlate with urinary oxalate excretion.	Oxalates	90-97	solute carrier family 26 member 1	Rattus norvegicus	35-42
22885878-0	2012	The role of the bridging group in exchange coupling in dinuclear homo- and heterometallic Ni(II) and Co(II) complexes with oxalate, oxamidate and dithiooxamidate bridges.	Oxalates	123-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
22771891-11	2012	Thus, one hypothetical component of the molecular basis for the excessive oxalate production in PH3 appears to be the inhibition of GR by HOG, resulting in a phenotype similar to PH2.	Oxalates	74-81	glyoxylate and hydroxypyruvate reductase	Homo sapiens	132-134
22594923-4	2012	The chloride-oxalate exchanger slc26a6 (also known as CFEX or PAT-1), located in the renal proximal tubule, was originally thought to have an important role in sodium homeostasis and thereby blood pressure control, but it has recently been shown to have a key function in oxalate balance by mediating oxalate secretion in the gut.	Oxalates	13-20	solute carrier family 26, member 6	Mus musculus	31-38
22594923-4	2012	The chloride-oxalate exchanger slc26a6 (also known as CFEX or PAT-1), located in the renal proximal tubule, was originally thought to have an important role in sodium homeostasis and thereby blood pressure control, but it has recently been shown to have a key function in oxalate balance by mediating oxalate secretion in the gut.	Oxalates	13-20	solute carrier family 26, member 6	Mus musculus	54-58
22594923-4	2012	The chloride-oxalate exchanger slc26a6 (also known as CFEX or PAT-1), located in the renal proximal tubule, was originally thought to have an important role in sodium homeostasis and thereby blood pressure control, but it has recently been shown to have a key function in oxalate balance by mediating oxalate secretion in the gut.	Oxalates	13-20	solute carrier family 26, member 6	Mus musculus	62-67
22594923-4	2012	The chloride-oxalate exchanger slc26a6 (also known as CFEX or PAT-1), located in the renal proximal tubule, was originally thought to have an important role in sodium homeostasis and thereby blood pressure control, but it has recently been shown to have a key function in oxalate balance by mediating oxalate secretion in the gut.	Oxalates	272-279	solute carrier family 26, member 6	Mus musculus	31-38
22594923-4	2012	The chloride-oxalate exchanger slc26a6 (also known as CFEX or PAT-1), located in the renal proximal tubule, was originally thought to have an important role in sodium homeostasis and thereby blood pressure control, but it has recently been shown to have a key function in oxalate balance by mediating oxalate secretion in the gut.	Oxalates	272-279	solute carrier family 26, member 6	Mus musculus	54-58
22594923-4	2012	The chloride-oxalate exchanger slc26a6 (also known as CFEX or PAT-1), located in the renal proximal tubule, was originally thought to have an important role in sodium homeostasis and thereby blood pressure control, but it has recently been shown to have a key function in oxalate balance by mediating oxalate secretion in the gut.	Oxalates	272-279	solute carrier family 26, member 6	Mus musculus	62-67
22821680-2	2012	Mutant AGXT leads to excess production and excretion of oxalate, resulting in accumulation of calcium oxalate in the kidney, and progressive loss of renal function.	Oxalates	56-63	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	7-11
21814770-0	2012	Selective Rac1 inhibition protects renal tubular epithelial cells from oxalate-induced NADPH oxidase-mediated oxidative cell injury.	Oxalates	71-78	Rac family small GTPase 1	Homo sapiens	10-14
21814770-4	2012	Our results show that oxalate significantly increased membrane translocation of Rac1 and NADPH oxidase activity of renal epithelial cells in a time-dependent manner.	Oxalates	22-29	Rac family small GTPase 1	Homo sapiens	80-84
21814770-5	2012	We found that NSC23766, a selective inhibitor of Rac1, blocked oxalate-induced membrane translocation of Rac1 and NADPH oxidase activity.	Oxalates	63-70	Rac family small GTPase 1	Homo sapiens	49-53
21814770-5	2012	We found that NSC23766, a selective inhibitor of Rac1, blocked oxalate-induced membrane translocation of Rac1 and NADPH oxidase activity.	Oxalates	63-70	Rac family small GTPase 1	Homo sapiens	105-109
21814770-7	2012	In contrast, Rac1 inhibitor pretreatment, significantly decreased oxalate-induced hydrogen peroxide production and LDH release.	Oxalates	66-73	Rac family small GTPase 1	Homo sapiens	13-17
21814770-10	2012	These findings suggest that Rac1 signaling plays a key role in oxalate-induced renal injury, and may serve as a potential therapeutic target to prevent calcium oxalate crystal deposition in stone formers and reduce recurrence.	Oxalates	63-70	Rac family small GTPase 1	Homo sapiens	28-32
22836206-4	2012	Under optimal conditions, the calibration curve of oxalate was linear between 3.0-50.0 mg L-1, with a limit of detection of 1.0 mg L-1.	Oxalates	51-58	immunoglobulin kappa variable 1-16	Homo sapiens	131-134
22836206-5	2012	The repeatability for a 30.0 mg L-1 oxalate solution was 0.7%.	Oxalates	36-43	immunoglobulin kappa variable 1-16	Homo sapiens	32-35
22494765-0	2012	Re: net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion.	Oxalates	32-39	solute carrier family 26 member 6	Homo sapiens	72-79
22839205-11	2012	CONCLUSIONS: Taken together, these results suggest that a brief treatment with oxaliplatin or its metabolite oxalate is sufficient to enhance the responsiveness of TRPA1 but not that of TRPM8 and TRPV1 expressed by DRG neurons, which may contribute to the characteristic acute peripheral neuropathy induced by oxaliplatin.	Oxalates	109-116	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	164-169
22807751-4	2012	The title structure gives the first example of the [Co(C2O4)3]4- anion, with the distorted octa-hedral environment of Co(II) center formed by six O atoms from three oxalate residues.	Oxalates	165-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
22517357-6	2012	Although the active secretory flux of oxalate across mouse duodenum was strongly inhibited (>90%) by addition of the disulfonic stilbene DIDS to the basolateral solution, secretion was unaffected by changes in medium concentrations of sulfate and bicarbonate, key substrates for Sat1-mediated anion exchange.	Oxalates	38-45	spermidine/spermine N1-acetyl transferase 1	Mus musculus	282-286
22319153-1	2012	The enzyme alanine-glyoxylate aminotransferase 1 (AGT) functions to detoxify glyoxylate before it is converted into harmful oxalate.	Oxalates	124-131	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	11-46
22342614-3	2012	Its isozyme glycolate oxidase (GOX), has a role in the formation of oxalate, which can lead to pathological deposits of calcium oxalate, in particular in the disease primary hyperoxaluria.	Oxalates	68-75	hydroxyacid oxidase 2	Homo sapiens	12-29
22342614-3	2012	Its isozyme glycolate oxidase (GOX), has a role in the formation of oxalate, which can lead to pathological deposits of calcium oxalate, in particular in the disease primary hyperoxaluria.	Oxalates	68-75	hydroxyacid oxidase 2	Homo sapiens	31-34
22321763-11	2012	Dipteran Prestin proteins appear suited for central roles in bicarbonate, sulfate and oxalate metabolism including generating the high pH conditions measured in the Dipteran midgut lumen.	Oxalates	86-93	prestin	Drosophila melanogaster	9-16
22189945-9	2012	These data suggest that GRHPR activity may be vital in the kidney for limiting the conversion of Hyp-derived glyoxylate to oxalate.	Oxalates	123-130	glyoxylate reductase/hydroxypyruvate reductase	Mus musculus	24-29
21660471-5	2012	One of the most important advances in understanding the molecular events associated with the Al exclusion mechanism was the identification of the ALMT1 gene (Al-activated malate transporter) in Triticum aestivum root cells, which codes for a plasma membrane anion channel that allows efflux of organic acid anions, such as malate, citrate or oxalate.	Oxalates	342-349	aluminum-activated malate transporter 1	Triticum aestivum	146-151
22190686-10	2012	Slc26a2 can transport oxalate in exchange for OH(-) and/or Cl(-) with properties similar to SO(4)(2-) transport.	Oxalates	22-29	solute carrier family 26 member 2	Homo sapiens	0-7
22447686-5	2012	Recombinant AAE3 protein has high activity against oxalate, with K(m) = 149.0 +- 12.7 muM and V(max) = 11.4 +- 1.0 mumol/min/mg protein, but no detectable activity against other organic acids tested.	Oxalates	51-58	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	12-16
22447686-6	2012	Allelic aae3 mutants lacked oxalyl-CoA synthetase activity and were unable to degrade oxalate into CO(2).	Oxalates	86-93	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	8-12
22447686-10	2012	Our results demonstrate that, in Arabidopsis, oxalyl-CoA synthetase encoded by AAE3 is required for oxalate degradation, for normal seed development, and for defense against an oxalate-producing fungal pathogen.	Oxalates	100-107	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	79-83
22447686-10	2012	Our results demonstrate that, in Arabidopsis, oxalyl-CoA synthetase encoded by AAE3 is required for oxalate degradation, for normal seed development, and for defense against an oxalate-producing fungal pathogen.	Oxalates	177-184	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	79-83
22206737-2	2012	DESIGN AND METHODS: A method is described for construction of an amperometric oxalate biosensor by immobilizing a barley root oxalate oxidase (OxOx) onto AuNPs-CaCO(3) porous microsphere hybrid encapsulated in silica sol and deposited on Au electrode.	Oxalates	78-85	LOC548260	Hordeum vulgare	126-141
22206737-2	2012	DESIGN AND METHODS: A method is described for construction of an amperometric oxalate biosensor by immobilizing a barley root oxalate oxidase (OxOx) onto AuNPs-CaCO(3) porous microsphere hybrid encapsulated in silica sol and deposited on Au electrode.	Oxalates	78-85	LOC548260	Hordeum vulgare	143-147
22206737-7	2012	CONCLUSION: The use of AuNPs-CaCO(3) porous microsphere hybrid as a support for immobilization of OxOx has resulted into an improved amperometric oxalate biosensor.	Oxalates	146-153	LOC548260	Hordeum vulgare	98-102
22512174-4	2012	The silver nanocap ordered arrays SERS-active substrate displayed not only higher SERS and fluorescence quenching effect, but also no interferential spectrum related with oxalate impurity remaining in PAA membranes, and therefore can result in the high quality Raman spectroscopy of bladder cancer cells.	Oxalates	171-178	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	34-38
21956166-12	2012	Biotinylation studies revealed that carbachol inhibits oxalate transport by reducing SLC26A6 surface expression.	Oxalates	55-62	solute carrier family 26 member 6	Homo sapiens	85-92
22292988-11	2012	Furthermore, oxalate (1.3 mg/kg) significantly induced the increase in TRPM8 protein in the DRG.	Oxalates	13-20	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	71-76
22292988-12	2012	Treatment with oxaliplatin and oxalate (500 muM for each) also increased the TRPM8 mRNA levels and induced Ca2+ influx and nuclear factor of activated T-cell (NFAT) nuclear translocation in cultured DRG cells.	Oxalates	31-38	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	77-82
22292988-12	2012	Treatment with oxaliplatin and oxalate (500 muM for each) also increased the TRPM8 mRNA levels and induced Ca2+ influx and nuclear factor of activated T-cell (NFAT) nuclear translocation in cultured DRG cells.	Oxalates	31-38	nuclear factor of activated T-cells 5	Rattus norvegicus	159-163
21956166-3	2012	Intestinal oxalate secretion mediated by anion exchanger SLC26A6 plays a major constitutive role in limiting net absorption of ingested oxalate, thereby preventing hyperoxaluria and calcium oxalate urolithiasis.	Oxalates	11-18	solute carrier family 26 member 6	Homo sapiens	57-64
21956166-6	2012	Knockdown studies demonstrated that endogenous SLC26A6 mediates most of the oxalate transport by T84 cells.	Oxalates	76-83	solute carrier family 26 member 6	Homo sapiens	47-54
21932131-4	2012	[(14)C]-oxalate-labelled COD crystals with intracrystalline (IC), surface-bound (SB) and IC + SB OPN, were generated from ultrafiltered (UF) urine containing 0, 1 and 5 mg/L human milk OPN and incubated with MDCKII cells, using UF urine as the binding medium.	Oxalates	8-15	secreted phosphoprotein 1	Homo sapiens	97-100
21932131-4	2012	[(14)C]-oxalate-labelled COD crystals with intracrystalline (IC), surface-bound (SB) and IC + SB OPN, were generated from ultrafiltered (UF) urine containing 0, 1 and 5 mg/L human milk OPN and incubated with MDCKII cells, using UF urine as the binding medium.	Oxalates	8-15	secreted phosphoprotein 1	Homo sapiens	185-188
21956166-13	2012	We conclude that carbachol negatively regulates oxalate transport by reducing SLC26A6 surface expression in T84 cells through signaling pathways including the M(3) muscarinic receptor, phospholipase C, PKC-delta, and c-Src.	Oxalates	48-55	solute carrier family 26 member 6	Homo sapiens	78-85
21956166-11	2012	Using pharmacological inhibitors, we observed that carbachol inhibits oxalate transport through the M(3) muscarinic receptor and phospholipase C. Utilizing the Src inhibitor PP2 and phosphorylation studies, we found that the observed regulation downstream of PKC-delta is partially mediated by c-Src.	Oxalates	70-77	cholinergic receptor muscarinic 3	Homo sapiens	100-124
21956166-11	2012	Using pharmacological inhibitors, we observed that carbachol inhibits oxalate transport through the M(3) muscarinic receptor and phospholipase C. Utilizing the Src inhibitor PP2 and phosphorylation studies, we found that the observed regulation downstream of PKC-delta is partially mediated by c-Src.	Oxalates	70-77	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	160-163
21956166-13	2012	We conclude that carbachol negatively regulates oxalate transport by reducing SLC26A6 surface expression in T84 cells through signaling pathways including the M(3) muscarinic receptor, phospholipase C, PKC-delta, and c-Src.	Oxalates	48-55	cholinergic receptor muscarinic 3	Homo sapiens	159-183
22466558-5	2012	Reverse transcription polymerase chain reaction (RT-PCR) analysis revealed that gallotannin significantly attenuated oxalate-induced mRNA and protein expressions of monocyte chemoattractant protein 1 (MCP-1), osteopontin (OPN), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit p22(phox) and p47(phox) in human primary renal epithelial cells (HRCs).	Oxalates	117-124	C-C motif chemokine ligand 2	Homo sapiens	165-199
22466558-5	2012	Reverse transcription polymerase chain reaction (RT-PCR) analysis revealed that gallotannin significantly attenuated oxalate-induced mRNA and protein expressions of monocyte chemoattractant protein 1 (MCP-1), osteopontin (OPN), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit p22(phox) and p47(phox) in human primary renal epithelial cells (HRCs).	Oxalates	117-124	C-C motif chemokine ligand 2	Homo sapiens	201-206
22466558-5	2012	Reverse transcription polymerase chain reaction (RT-PCR) analysis revealed that gallotannin significantly attenuated oxalate-induced mRNA and protein expressions of monocyte chemoattractant protein 1 (MCP-1), osteopontin (OPN), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit p22(phox) and p47(phox) in human primary renal epithelial cells (HRCs).	Oxalates	117-124	secreted phosphoprotein 1	Homo sapiens	209-220
22466558-5	2012	Reverse transcription polymerase chain reaction (RT-PCR) analysis revealed that gallotannin significantly attenuated oxalate-induced mRNA and protein expressions of monocyte chemoattractant protein 1 (MCP-1), osteopontin (OPN), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit p22(phox) and p47(phox) in human primary renal epithelial cells (HRCs).	Oxalates	117-124	secreted phosphoprotein 1	Homo sapiens	222-225
22466558-5	2012	Reverse transcription polymerase chain reaction (RT-PCR) analysis revealed that gallotannin significantly attenuated oxalate-induced mRNA and protein expressions of monocyte chemoattractant protein 1 (MCP-1), osteopontin (OPN), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit p22(phox) and p47(phox) in human primary renal epithelial cells (HRCs).	Oxalates	117-124	calcineurin like EF-hand protein 1	Homo sapiens	296-305
22466558-5	2012	Reverse transcription polymerase chain reaction (RT-PCR) analysis revealed that gallotannin significantly attenuated oxalate-induced mRNA and protein expressions of monocyte chemoattractant protein 1 (MCP-1), osteopontin (OPN), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit p22(phox) and p47(phox) in human primary renal epithelial cells (HRCs).	Oxalates	117-124	pleckstrin	Homo sapiens	310-313
22466558-5	2012	Reverse transcription polymerase chain reaction (RT-PCR) analysis revealed that gallotannin significantly attenuated oxalate-induced mRNA and protein expressions of monocyte chemoattractant protein 1 (MCP-1), osteopontin (OPN), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit p22(phox) and p47(phox) in human primary renal epithelial cells (HRCs).	Oxalates	117-124	calcineurin like EF-hand protein 1	Homo sapiens	300-304
22984472-0	2012	Kidney injury molecule-1 is up-regulated in renal epithelial cells in response to oxalate in vitro and in renal tissues in response to hyperoxaluria in vivo.	Oxalates	82-89	hepatitis A virus cellular receptor 1	Homo sapiens	0-24
23146788-4	2012	AIM OF THE STUDY: was to evaluate the BRI (bonn risk index - rate of spontaneous crystallization of calcium oxalate), the concentration of oxalate, citrate and urine pH in children with acid-base balance disturbances occurring in patients with newly diagnosed type 1 diabetes (DMT1).	Oxalates	108-115	integral membrane protein 2B	Homo sapiens	38-41
23028475-0	2012	Genome wide analysis of differentially expressed genes in HK-2 cells, a line of human kidney epithelial cells in response to oxalate.	Oxalates	125-132	hexokinase 2	Homo sapiens	58-62
23430879-9	2012	Sequential liver transplantation followed by kidney transplantation is to be considered for PH I patients who have ESRD and very high oxalate load.	Oxalates	134-141	glucose-6-phosphate isomerase	Homo sapiens	92-96
22984472-6	2012	In the present study we evaluated changes in expression of Kidney Injury Molecule-1 (KIM-1) in response to oxalate in human renal cells (HK2 cells) in culture and in renal tissue and urine samples in hyperoxaluric animals which mimic in vitro and in vivo models of hyper-oxaluria.	Oxalates	107-114	hepatitis A virus cellular receptor 1	Homo sapiens	59-83
22984472-6	2012	In the present study we evaluated changes in expression of Kidney Injury Molecule-1 (KIM-1) in response to oxalate in human renal cells (HK2 cells) in culture and in renal tissue and urine samples in hyperoxaluric animals which mimic in vitro and in vivo models of hyper-oxaluria.	Oxalates	107-114	hepatitis A virus cellular receptor 1	Homo sapiens	85-90
22984472-7	2012	Results presented, herein demonstrate that oxalate exposure resulted in increased expression of KIM-1 m RNA as well as protein in HK2 cells.	Oxalates	43-50	hepatitis A virus cellular receptor 1	Homo sapiens	96-101
22984472-10	2012	The increase in KIM-1 was both at protein and mRNA level, suggesting transcriptional activation of KIM-1 in response to oxalate exposure.	Oxalates	120-127	hepatitis A virus cellular receptor 1	Homo sapiens	16-21
22984472-10	2012	The increase in KIM-1 was both at protein and mRNA level, suggesting transcriptional activation of KIM-1 in response to oxalate exposure.	Oxalates	120-127	hepatitis A virus cellular receptor 1	Homo sapiens	99-104
22984472-12	2012	To the best of our knowledge our studies are the first direct demonstration of regulation of KIM-1 in response to oxalate exposure in renal epithelial cells in vitro and in vivo.	Oxalates	114-121	hepatitis A virus cellular receptor 1	Homo sapiens	93-98
21684033-1	2011	Oxalate oxidase (OXO) utilizes oxalate to generate hydrogen peroxide, and thereby acts as a source of hydrogen peroxide.	Oxalates	31-38	germin-like protein 8-4	Triticum aestivum	0-15
22956877-4	2012	PH1 was confirmed by high urinary oxalate level, demonstration of oxalate crystals in bone biopsy, and pathogenic homozygous known AGXT gene mutation.	Oxalates	34-41	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	0-3
22956877-4	2012	PH1 was confirmed by high urinary oxalate level, demonstration of oxalate crystals in bone biopsy, and pathogenic homozygous known AGXT gene mutation.	Oxalates	66-73	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	0-3
22021714-6	2011	In Slc26a6-null mice, secretory flux of oxalate was similar to mannitol, and no net flux of oxalate occurred.	Oxalates	40-47	solute carrier family 26, member 6	Mus musculus	3-10
22021714-8	2011	In epithelial cell lines, modulation of the charge selectivity of the claudin-based pore pathway did not affect oxalate permeability, but knockdown of the tight-junction protein ZO-1 enhanced permeability to oxalate and mannitol in parallel.	Oxalates	208-215	tight junction protein 1	Mus musculus	178-182
22021714-10	2011	In conclusion, absorptive oxalate flux occurs through the paracellular "leak" pathway, and net absorption of dietary oxalate depends on the relative balance between absorption and SLC26A6-dependent transcellular secretion.	Oxalates	117-124	solute carrier family 26, member 6	Mus musculus	180-187
22101801-2	2012	Oxalate and aziridine-carboxylate was conjugated to serum transferrin in order to transport into the targeted cancer cells via transferrin-receptor mediated endocytosis.	Oxalates	0-7	transferrin	Homo sapiens	58-69
22101801-2	2012	Oxalate and aziridine-carboxylate was conjugated to serum transferrin in order to transport into the targeted cancer cells via transferrin-receptor mediated endocytosis.	Oxalates	0-7	transferrin	Homo sapiens	127-138
22021714-0	2011	Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion.	Oxalates	28-35	solute carrier family 26, member 6	Mus musculus	68-75
22021714-1	2011	Mice lacking the oxalate transporter SLC26A6 develop hyperoxalemia, hyperoxaluria, and calcium-oxalate stones as a result of a defect in intestinal oxalate secretion, but what accounts for the absorptive oxalate flux remains unknown.	Oxalates	17-24	solute carrier family 26, member 6	Mus musculus	37-44
22021714-1	2011	Mice lacking the oxalate transporter SLC26A6 develop hyperoxalemia, hyperoxaluria, and calcium-oxalate stones as a result of a defect in intestinal oxalate secretion, but what accounts for the absorptive oxalate flux remains unknown.	Oxalates	95-102	solute carrier family 26, member 6	Mus musculus	37-44
21981408-7	2011	The NGF-induced upregulation of growth-associated protein-43 (GAP-43) was suppressed by oxaliplatin and oxalate.	Oxalates	104-111	growth associated protein 43	Rattus norvegicus	32-60
21981408-7	2011	The NGF-induced upregulation of growth-associated protein-43 (GAP-43) was suppressed by oxaliplatin and oxalate.	Oxalates	104-111	growth associated protein 43	Rattus norvegicus	62-68
21896830-2	2011	Recently, we described type III, due to mutations in HOGA1 (formerly DHDPSL), hypothesized to cause a gain of mitochondrial 4-hydroxy-2-oxoglutarate aldolase activity, resulting in excess oxalate.	Oxalates	188-195	4-hydroxy-2-oxoglutarate aldolase 1	Homo sapiens	53-58
22111829-11	2011	Erythropoietin-resistant anemia and hypothyroidism were thought to be due to accumulation of oxalate in the bone marrow and thyroid gland, respectively.	Oxalates	93-100	erythropoietin	Homo sapiens	0-14
21896830-2	2011	Recently, we described type III, due to mutations in HOGA1 (formerly DHDPSL), hypothesized to cause a gain of mitochondrial 4-hydroxy-2-oxoglutarate aldolase activity, resulting in excess oxalate.	Oxalates	188-195	4-hydroxy-2-oxoglutarate aldolase 1	Homo sapiens	69-75
21896830-4	2011	Postulating that HOGA1 may influence urine oxalate, we also screened 100 idiopathic calcium oxalate stone formers.	Oxalates	43-50	4-hydroxy-2-oxoglutarate aldolase 1	Homo sapiens	17-22
21119625-1	2011	Primary hyperoxaluria type I (PH1) is an inborn error of metabolism caused by deficiency of the hepatic enzyme alanine-glyoxylate aminotransferase (AGXT or AGT) which leads to overproduction of oxalate by the liver and subsequent urolithiasis and renal failure.	Oxalates	194-201	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	148-152
21490138-7	2011	Experimental data indicate that NaS1 is essential for maintaining sulfate homeostasis, whereas Sat1 controls both sulfate and oxalate homeostasis in vivo.	Oxalates	126-133	solute carrier family 26 (sulfate transporter), member 1	Mus musculus	95-99
21079197-0	2011	Temporal changes in the expression of mRNA of NADPH oxidase subunits in renal epithelial cells exposed to oxalate or calcium oxalate crystals.	Oxalates	106-113	2,4-dienoyl-CoA reductase 1	Homo sapiens	46-51
21161647-11	2011	Results suggest that at least in mice (1) Increase in oxalate and decrease in citrate excretion can lead to CaOx crystalluria but not CaOx nephrolithiasis; (2) MCP-1 does not play a role in crystal retention within the kidneys; (3) Expression of OPN and MCP-1 is not increased in the kidneys in the absence of crystal deposition; (4) Crystal deposition is necessary for significant pathological changes and movement of monocytes and macrophages into the interstitium.	Oxalates	54-61	chemokine (C-C motif) ligand 2	Mus musculus	160-165
21458484-1	2011	Glycolate oxidase (GOX) is one of the principal enzymes involved in the pathway of oxalate synthesis.	Oxalates	83-90	hydroxyacid oxidase 2	Homo sapiens	0-17
21458484-1	2011	Glycolate oxidase (GOX) is one of the principal enzymes involved in the pathway of oxalate synthesis.	Oxalates	83-90	hydroxyacid oxidase 2	Homo sapiens	19-22
21490138-3	2011	Sat1 also mediates renal oxalate transport and controls blood oxalate levels.	Oxalates	25-32	solute carrier family 26 (sulfate transporter), member 1	Mus musculus	0-4
21490138-6	2011	NaS1 and Sat1 null mice also have other phenotypes that result due to changes in blood sulfate and oxalate levels.	Oxalates	99-106	solute carrier family 13 (sodium/sulfate symporters), member 1	Mus musculus	0-4
21490138-6	2011	NaS1 and Sat1 null mice also have other phenotypes that result due to changes in blood sulfate and oxalate levels.	Oxalates	99-106	solute carrier family 26 (sulfate transporter), member 1	Mus musculus	9-13
21119625-1	2011	Primary hyperoxaluria type I (PH1) is an inborn error of metabolism caused by deficiency of the hepatic enzyme alanine-glyoxylate aminotransferase (AGXT or AGT) which leads to overproduction of oxalate by the liver and subsequent urolithiasis and renal failure.	Oxalates	194-201	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	156-159
21298488-7	2011	These data indicate that the renal anion transporters NaS1 and Sat1 are essential for sulfate and oxalate homeostasis, respectively.	Oxalates	98-105	solute carrier family 13 member 1	Homo sapiens	54-58
21298488-7	2011	These data indicate that the renal anion transporters NaS1 and Sat1 are essential for sulfate and oxalate homeostasis, respectively.	Oxalates	98-105	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	63-67
21255608-6	2011	Oxalate oxidase (OxOx) is a commonly occurring enzyme in plants, bacteria and fungi that catalyses oxidative cleavage of oxalate to CO(2) with reduction of dioxygen to H(2)O(2).	Oxalates	121-128	germin-like protein 8-4	Triticum aestivum	0-15
21255608-6	2011	Oxalate oxidase (OxOx) is a commonly occurring enzyme in plants, bacteria and fungi that catalyses oxidative cleavage of oxalate to CO(2) with reduction of dioxygen to H(2)O(2).	Oxalates	121-128	germin-like protein 8-4	Triticum aestivum	17-21
21255608-11	2011	Calculated interaction energy between the oxalate and constructed enzyme indicated that homology models for OxOx of T. aestivum, A. thaliana and S. sclerotiarum, can account for better regio-specificity of this enzyme towards oxalate.	Oxalates	42-49	germin-like protein 8-4	Triticum aestivum	108-112
21255608-11	2011	Calculated interaction energy between the oxalate and constructed enzyme indicated that homology models for OxOx of T. aestivum, A. thaliana and S. sclerotiarum, can account for better regio-specificity of this enzyme towards oxalate.	Oxalates	226-233	germin-like protein 8-4	Triticum aestivum	108-112
25013605-1	2011	Primary hyperoxaluria type-1 (PH1) is a rare inherited autosomal recessive disorder in which a deficiency of the hepatic enzyme alanine-glyoxylate aminotransferase leads to endogenous oxalate overproduction, renal failure, systemic oxalate deposition and death.	Oxalates	184-191	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
25984128-1	2011	Liver-kidney transplantation in patients with primary hyperoxaluria type 1 (PH1) and a high systemic oxalate load is often complicated by oxalate deposition in the renal allograft and loss of renal function.	Oxalates	138-145	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	76-79
25984128-4	2011	In two PH1 patients with extensive oxalate accumulation, we found that intra-operative continuous venovenous haemodiafiltration effectively cleared oxalate and kept oxalate at relatively low levels following preoperative HD.	Oxalates	35-42	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	7-10
25984128-4	2011	In two PH1 patients with extensive oxalate accumulation, we found that intra-operative continuous venovenous haemodiafiltration effectively cleared oxalate and kept oxalate at relatively low levels following preoperative HD.	Oxalates	148-155	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	7-10
25984128-4	2011	In two PH1 patients with extensive oxalate accumulation, we found that intra-operative continuous venovenous haemodiafiltration effectively cleared oxalate and kept oxalate at relatively low levels following preoperative HD.	Oxalates	148-155	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	7-10
21163900-7	2011	Our results demonstrate that the cecum and distal colon contribute significantly to enteric oxalate excretion in Oxalobacter-colonized Agxt and WT mice.	Oxalates	92-99	alanine-glyoxylate aminotransferase	Mus musculus	135-139
21163900-8	2011	In colonized Agxt mice, urinary oxalate excretion was reduced 50% (to within the normal range observed for WT mice).	Oxalates	32-39	alanine-glyoxylate aminotransferase	Mus musculus	13-17
21163900-9	2011	Moreover, plasma oxalate concentrations in Agxt mice were also normalized (reduced 50%).	Oxalates	17-24	alanine-glyoxylate aminotransferase	Mus musculus	43-47
21327226-2	2011	Co(12)(OH)(18)(ox)(3)(pip) [ox = oxalate, C(2)O(4)(2-); pip = piperazine, C(4)N(2)H(10)] (1), is essentially built from brucite-like layers with a one ninth depletion of the octahedral sites and a preservation of a trigonal crystallographic symmetry.	Oxalates	33-40	prolactin induced protein	Homo sapiens	22-25
21093948-3	2011	Since the sulfate anion transporter-1(sat-1) is present in the sinusoidal membrane of hepatocytes and translocates oxalate, its impact on increased oxalate synthesis was studied.	Oxalates	115-122	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	10-43
21093948-3	2011	Since the sulfate anion transporter-1(sat-1) is present in the sinusoidal membrane of hepatocytes and translocates oxalate, its impact on increased oxalate synthesis was studied.	Oxalates	148-155	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	10-43
21093948-4	2011	METHODS: Sat-1 expressing oocytes were used for cis-inhibition, trans-stimulation, and efflux experiments with labelled sulfate and oxalate to demonstrate the interactions of oxalate, glyoxylate, and glycolate with sat-1.	Oxalates	175-182	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	9-14
21093948-12	2011	Glyoxylate was the only oxalate precursor stimulating sat-1 mRNA-expression.	Oxalates	24-31	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	54-59
21304260-3	2011	The activity of serine : pyruvate/alanine : glyoxylate aminotransferase (SPT/AGT) or glyoxylate reductase/hydroxypyruvate reductase (GRHPR), the key enzyme of primary hyperoxlauria type 1 and 2, respectively, and their subcellular distribution highly affects the oxalate production.	Oxalates	263-270	glyoxylate and hydroxypyruvate reductase	Homo sapiens	85-105
21304260-3	2011	The activity of serine : pyruvate/alanine : glyoxylate aminotransferase (SPT/AGT) or glyoxylate reductase/hydroxypyruvate reductase (GRHPR), the key enzyme of primary hyperoxlauria type 1 and 2, respectively, and their subcellular distribution highly affects the oxalate production.	Oxalates	263-270	glyoxylate and hydroxypyruvate reductase	Homo sapiens	106-131
21304260-3	2011	The activity of serine : pyruvate/alanine : glyoxylate aminotransferase (SPT/AGT) or glyoxylate reductase/hydroxypyruvate reductase (GRHPR), the key enzyme of primary hyperoxlauria type 1 and 2, respectively, and their subcellular distribution highly affects the oxalate production.	Oxalates	263-270	glyoxylate and hydroxypyruvate reductase	Homo sapiens	133-138
21304262-14	2011	These results show that oxalate can activate the renal renin-angiotensin system and that oxalate-induced upregulation of OPN is in part mediated via the renal renin-angiotensin system.	Oxalates	89-96	secreted phosphoprotein 1	Rattus norvegicus	121-124
21748001-2	2011	PH type 1, the most common form, is an autosomal recessive disorder caused by a deficiency of the liver-specific enzyme alanine, glyoxylate aminotransferase (AGT) resulting in overproduction and excessive urinary excretion of oxalate.	Oxalates	226-233	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	120-156
21748001-2	2011	PH type 1, the most common form, is an autosomal recessive disorder caused by a deficiency of the liver-specific enzyme alanine, glyoxylate aminotransferase (AGT) resulting in overproduction and excessive urinary excretion of oxalate.	Oxalates	226-233	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	158-161
25013605-1	2011	Primary hyperoxaluria type-1 (PH1) is a rare inherited autosomal recessive disorder in which a deficiency of the hepatic enzyme alanine-glyoxylate aminotransferase leads to endogenous oxalate overproduction, renal failure, systemic oxalate deposition and death.	Oxalates	232-239	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
21170874-0	2010	Role of SLC26A6-mediated Cl--oxalate exchange in renal physiology and pathophysiology.	Oxalates	29-36	solute carrier family 26, member 6	Mus musculus	8-15
20947140-0	2011	Importance of erythrocyte band III anion transporter (SLC4A1) on oxalate clearance of calcium oxalate monohydrate stone-formering patients vs. normal controls.	Oxalates	65-72	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	54-60
20947140-10	2011	CONCLUSIONS: SLC4A1 associated changes of HCO(3)(-) and pH levels influenced the cellular oxalate levels and urinary oxalate clearance.	Oxalates	90-97	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	13-19
20947140-10	2011	CONCLUSIONS: SLC4A1 associated changes of HCO(3)(-) and pH levels influenced the cellular oxalate levels and urinary oxalate clearance.	Oxalates	117-124	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	13-19
21558762-4	2011	In herbivores, peroxisomal localization of SPT appears to be indispensable to prevent excessive oxalate production by removing glyoxylate, an immediate precursor of oxalate, formed from glycolate in this organelle.	Oxalates	96-103	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	43-46
21558762-4	2011	In herbivores, peroxisomal localization of SPT appears to be indispensable to prevent excessive oxalate production by removing glyoxylate, an immediate precursor of oxalate, formed from glycolate in this organelle.	Oxalates	165-172	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	43-46
21170874-3	2010	Subsequent studies identified anion transporter SLC26A6 as responsible for proximal tubule Cl--oxalate exchange activity.	Oxalates	95-102	solute carrier family 26, member 6	Mus musculus	48-55
21170874-5	2010	Hyperoxalemia and hyperoxaluria in Slc26a6 null mice were found to be caused by defective intestinal back-secretion of ingested oxalate.	Oxalates	128-135	solute carrier family 26, member 6	Mus musculus	35-42
21170874-6	2010	These findings suggested that inherited or acquired defects in SLC26A6 might lead to hyperoxaluria and increased stone risk, and have motivated studies to characterize the role of SLC26A6 in oxalate homeostasis in patients and in animal models.	Oxalates	191-198	solute carrier family 26 member 6	Homo sapiens	180-187
20219950-5	2010	hSLC26A2-mediated bidirectional oxalate/SO(4)(2-) exchange exhibited extracellular SO(4)(2-) K(1/2) of 1.58 +/- 0.44 mM for exchange with intracellular [(14)C]oxalate, and extracellular oxalate K(1/2) of 0.14 +/- 0.11 mM for exchange with intracellular (35)SO(4)(2-).	Oxalates	32-39	solute carrier family 26 member 2	Homo sapiens	0-8
20219950-0	2010	Regulated transport of sulfate and oxalate by SLC26A2/DTDST.	Oxalates	35-42	solute carrier family 26 (sulfate transporter), member 2	Mus musculus	46-53
20219950-2	2010	The molecular identities of enterocyte pathways for oxalate absorption and for Slc26a6-independent oxalate secretion remain undefined.	Oxalates	99-106	solute carrier family 26, member 6	Mus musculus	79-86
20219950-3	2010	The reported intestinal expression of SO(4)(2-) transporter SLC26A2 prompted us to characterize transport of oxalate and other anions by human SLC26A2 and mouse Slc26a2 expressed in Xenopus oocytes.	Oxalates	109-116	solute carrier family 26 member 2	Homo sapiens	60-67
20219950-3	2010	The reported intestinal expression of SO(4)(2-) transporter SLC26A2 prompted us to characterize transport of oxalate and other anions by human SLC26A2 and mouse Slc26a2 expressed in Xenopus oocytes.	Oxalates	109-116	solute carrier family 26 member 2	Homo sapiens	143-150
20219950-3	2010	The reported intestinal expression of SO(4)(2-) transporter SLC26A2 prompted us to characterize transport of oxalate and other anions by human SLC26A2 and mouse Slc26a2 expressed in Xenopus oocytes.	Oxalates	109-116	solute carrier family 26 (sulfate transporter), member 2	Mus musculus	161-168
20219950-7	2010	hSLC26A2-mediated oxalate/Cl(-) exchange and bidirectional SO(4)(2-)/Cl(-) exchange were not detectably electrogenic.	Oxalates	18-25	solute carrier family 26 member 2	Homo sapiens	0-8
20219950-13	2010	Diastrophic dysplasia mutants R279W and A386V of hSLC26A2 exhibited similar reductions in uptake of both (35)SO(4)(2-) and [(14)C]oxalate.	Oxalates	130-137	solute carrier family 26 member 2	Homo sapiens	49-57
20160351-4	2010	The sulfate anion transporter-1 (Sat1; also known as Slc26a1) mediates epithelial transport of oxalate and sulfate, and its localization in the kidney, liver, and intestine suggests that it may play a role in oxalate and sulfate homeostasis.	Oxalates	95-102	solute carrier family 26 (sulfate transporter), member 1	Mus musculus	4-31
20163845-8	2010	Increases in urinary oxalate excretion paralleled renal crystal deposition, which were both enhanced by testosterone treatment through increased glycolate oxidase expression.	Oxalates	21-28	hydroxyacid oxidase 1	Rattus norvegicus	145-162
20172583-7	2010	The addition of oxalate and humic acids significantly inhibited the MS2 inactivation, whereas 1,10-phenanthroline and bipyridine resulted in a gradual and steady inactivation of MS2.	Oxalates	16-23	MS2	Homo sapiens	68-71
20172583-7	2010	The addition of oxalate and humic acids significantly inhibited the MS2 inactivation, whereas 1,10-phenanthroline and bipyridine resulted in a gradual and steady inactivation of MS2.	Oxalates	16-23	MS2	Homo sapiens	178-181
20160351-4	2010	The sulfate anion transporter-1 (Sat1; also known as Slc26a1) mediates epithelial transport of oxalate and sulfate, and its localization in the kidney, liver, and intestine suggests that it may play a role in oxalate and sulfate homeostasis.	Oxalates	95-102	solute carrier family 26 (sulfate transporter), member 1	Mus musculus	33-37
20160351-4	2010	The sulfate anion transporter-1 (Sat1; also known as Slc26a1) mediates epithelial transport of oxalate and sulfate, and its localization in the kidney, liver, and intestine suggests that it may play a role in oxalate and sulfate homeostasis.	Oxalates	95-102	solute carrier family 26 (sulfate transporter), member 1	Mus musculus	53-60
20160351-4	2010	The sulfate anion transporter-1 (Sat1; also known as Slc26a1) mediates epithelial transport of oxalate and sulfate, and its localization in the kidney, liver, and intestine suggests that it may play a role in oxalate and sulfate homeostasis.	Oxalates	209-216	solute carrier family 26 (sulfate transporter), member 1	Mus musculus	4-31
20160351-4	2010	The sulfate anion transporter-1 (Sat1; also known as Slc26a1) mediates epithelial transport of oxalate and sulfate, and its localization in the kidney, liver, and intestine suggests that it may play a role in oxalate and sulfate homeostasis.	Oxalates	209-216	solute carrier family 26 (sulfate transporter), member 1	Mus musculus	33-37
20160351-4	2010	The sulfate anion transporter-1 (Sat1; also known as Slc26a1) mediates epithelial transport of oxalate and sulfate, and its localization in the kidney, liver, and intestine suggests that it may play a role in oxalate and sulfate homeostasis.	Oxalates	209-216	solute carrier family 26 (sulfate transporter), member 1	Mus musculus	53-60
20160351-8	2010	These data suggest that Sat1 regulates both oxalate and sulfate homeostasis and may be critical to the development of calcium oxalate urolithiasis and hepatotoxicity.	Oxalates	44-51	solute carrier family 26 (sulfate transporter), member 1	Mus musculus	24-28
19907019-4	2010	AE1 E758K expression was also associated with GPA-dependent increases of DIDS-sensitive pH-independent SO(4)(2-) uptake and oxalate uptake with altered pH dependence.	Oxalates	124-131	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	0-3
19907019-4	2010	AE1 E758K expression was also associated with GPA-dependent increases of DIDS-sensitive pH-independent SO(4)(2-) uptake and oxalate uptake with altered pH dependence.	Oxalates	124-131	glycophorin A (MNS blood group)	Homo sapiens	46-49
19740751-8	2009	Oxalate-supported Ca(2+) uptake showed increased Ca(2+) sensitivity of SERCA2 in calumenin KD HL-1 cells.	Oxalates	0-7	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	71-77
20689249-0	2010	Matrix Gla protein expression in NRK-52E cells exposed to oxalate and calcium oxalate monohydrate crystals.	Oxalates	58-65	matrix Gla protein	Rattus norvegicus	0-18
20689249-2	2010	Here, we characterized MGP expression in cultured renal tubular epithelial cells exposed to oxalate and calcium oxalate monohydrate (COM) crystals.	Oxalates	92-99	matrix Gla protein	Rattus norvegicus	23-26
20689249-4	2010	RESULTS: MGP was expressed rapidly and intensively following exposure to COM and was time-dependent with exposure to oxalate.	Oxalates	117-124	matrix Gla protein	Rattus norvegicus	9-12
20689249-5	2010	CONCLUSION: Our results have given a profile of MGP expression in renal tubular epithelial cells exposed to oxalate and crystals and provided support for an association between MGP and kidney stones.	Oxalates	108-115	matrix Gla protein	Rattus norvegicus	48-51
19622348-12	2009	In conclusion, we propose as one mechanism for FOLFOX synergism the 5-FU mediated suppression of ATP7B, the over-expression of glutathione exporters such as MRP2/ABCC2 and the decrease of glutathione levels by oxalate.	Oxalates	210-217	ATP binding cassette subfamily C member 2	Homo sapiens	157-161
19622348-12	2009	In conclusion, we propose as one mechanism for FOLFOX synergism the 5-FU mediated suppression of ATP7B, the over-expression of glutathione exporters such as MRP2/ABCC2 and the decrease of glutathione levels by oxalate.	Oxalates	210-217	ATP binding cassette subfamily C member 2	Homo sapiens	162-167
19692488-0	2009	Oxalate-induced activation of PKC-alpha and -delta regulates NADPH oxidase-mediated oxidative injury in renal tubular epithelial cells.	Oxalates	0-7	PRKCD	Sus scrofa	30-50
19692488-4	2009	Oxalate markedly translocated PKC-alpha and -delta from the cytosol to the cell membrane.	Oxalates	0-7	PRKCD	Sus scrofa	30-50
20501439-1	2009	The purpose of this investigation was to quantitate the contribution of the anion exchanger PAT-1 (putative anion transporter-1), encoded by SLC26A6, to oxalate transport in a model intestinal epithelium and to discern some characteristics of this exchanger expressed in its native environment.	Oxalates	153-160	solute carrier family 36 member 1	Homo sapiens	92-97
20501439-1	2009	The purpose of this investigation was to quantitate the contribution of the anion exchanger PAT-1 (putative anion transporter-1), encoded by SLC26A6, to oxalate transport in a model intestinal epithelium and to discern some characteristics of this exchanger expressed in its native environment.	Oxalates	153-160	solute carrier family 36 member 1	Homo sapiens	99-127
20501439-1	2009	The purpose of this investigation was to quantitate the contribution of the anion exchanger PAT-1 (putative anion transporter-1), encoded by SLC26A6, to oxalate transport in a model intestinal epithelium and to discern some characteristics of this exchanger expressed in its native environment.	Oxalates	153-160	solute carrier family 26 member 6	Homo sapiens	141-148
19740751-8	2009	Oxalate-supported Ca(2+) uptake showed increased Ca(2+) sensitivity of SERCA2 in calumenin KD HL-1 cells.	Oxalates	0-7	calumenin	Mus musculus	81-90
19715318-0	2009	Oxalate-bridged bimetallic complexes {NH(prol)3}[MCr(ox)3] (M = Mn(II), Fe(II), Co(II); NH(prol)3(+) = tri(3-hydroxypropyl)ammonium) exhibiting coexistent ferromagnetism and proton conduction.	Oxalates	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
19496983-1	2009	PH1 is a metabolic disorder characterized by urolithiasis and the accumulation of oxalate crystals in the kidneys and other organs.	Oxalates	82-89	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	0-3
19324057-1	2009	Transferrin (Tf) is an enigmatic metalloprotein that exhibits a profound conformational change upon binding of ferric ion and a synergistic anion (oxalate or carbonate).	Oxalates	147-154	transferrin	Homo sapiens	0-11
19369292-0	2009	Ability of sat-1 to transport sulfate, bicarbonate, or oxalate under physiological conditions.	Oxalates	55-62	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	11-16
19369292-8	2009	These data and electrophysiological studies using a two-electrode voltage-clamp device provide evidence that sat-1 preferentially works as an electroneutral sulfate-bicarbonate or oxalate-bicarbonate exchanger.	Oxalates	180-187	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	109-114
19324057-1	2009	Transferrin (Tf) is an enigmatic metalloprotein that exhibits a profound conformational change upon binding of ferric ion and a synergistic anion (oxalate or carbonate).	Oxalates	147-154	transferrin	Homo sapiens	13-15
19326938-1	2009	ATR-FTIR and EXAFS study of the aqueous Zn(II)/oxalate/hematite ternary system.	Oxalates	47-54	ATR serine/threonine kinase	Homo sapiens	0-3
19326938-7	2009	In the Zn(II)/Ox/HN ternary system at R=0.15, ATR-FTIR results indicate the presence of inner-sphere oxalate and outer-sphere ZnOx(aq) complexes; the EXAFS results provide no evidence for inner-sphere Zn(II) complexes or type A ternary complexes.	Oxalates	101-108	ATR serine/threonine kinase	Homo sapiens	46-49
19839830-8	2009	PJ was found to have inhibitory effects on renal tubular cell injury and oxidative stress caused by oxalate crystals by reducing ROS, iNOS, p38-MAPK, and NF-kB expression.	Oxalates	100-107	mitogen activated protein kinase 14	Rattus norvegicus	140-148
19002488-8	2009	The male-dominant abundance of sat-1 protein in liver may conform to elevated uptake of sulfate and extrusion of oxalate, causing higher plasma oxalate in males.	Oxalates	144-151	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	31-36
19002488-9	2009	Oxalate is then excreted by the kidneys via the basolateral sat-1 (males > females) and the apical CFEX (Slc26a6; GD unknown) in PT and eliminated in the urine (males > females), where it may contribute to the male-prevailing development of oxalate urolithiasis.	Oxalates	0-7	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	60-65
19002488-9	2009	Oxalate is then excreted by the kidneys via the basolateral sat-1 (males > females) and the apical CFEX (Slc26a6; GD unknown) in PT and eliminated in the urine (males > females), where it may contribute to the male-prevailing development of oxalate urolithiasis.	Oxalates	0-7	solute carrier family 26 member 6	Rattus norvegicus	108-115
18992290-1	2009	We previously demonstrated that decreasing the iron release rate of transferrin (Tf), by replacing the synergistic anion carbonate with oxalate, increases its in vitro drug carrier efficacy in HeLa cells.	Oxalates	136-143	transferrin	Homo sapiens	68-79
18992290-1	2009	We previously demonstrated that decreasing the iron release rate of transferrin (Tf), by replacing the synergistic anion carbonate with oxalate, increases its in vitro drug carrier efficacy in HeLa cells.	Oxalates	136-143	transferrin	Homo sapiens	81-83
19839830-8	2009	PJ was found to have inhibitory effects on renal tubular cell injury and oxidative stress caused by oxalate crystals by reducing ROS, iNOS, p38-MAPK, and NF-kB expression.	Oxalates	100-107	nitric oxide synthase 2	Rattus norvegicus	134-138
19296982-2	2009	Primary hyperoxaluria type 2 is a rare autosomal recessive disease caused by mutations in the GRHPR gene, leading to an accumulation of oxalate and L-glycerate with recurrent kidney stone formation and nephrocalcinosis, and the later development of renal failure and systemic oxalate depositions.	Oxalates	136-143	glyoxylate and hydroxypyruvate reductase	Homo sapiens	94-99
19296982-2	2009	Primary hyperoxaluria type 2 is a rare autosomal recessive disease caused by mutations in the GRHPR gene, leading to an accumulation of oxalate and L-glycerate with recurrent kidney stone formation and nephrocalcinosis, and the later development of renal failure and systemic oxalate depositions.	Oxalates	276-283	glyoxylate and hydroxypyruvate reductase	Homo sapiens	94-99
19002488-8	2009	The male-dominant abundance of sat-1 protein in liver may conform to elevated uptake of sulfate and extrusion of oxalate, causing higher plasma oxalate in males.	Oxalates	113-120	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	31-36
19029225-3	2009	Recently, the anion-exchanger SLC26A6 has been involved in the oxalate metabolism.	Oxalates	63-70	solute carrier family 26 member 6	Homo sapiens	30-37
18698135-2	2009	We tested an oral therapy with a crystalline, cross-linked formulation of oxalate-decarboxylase (OxDc-CLEC) on the reduction of urinary oxalate and decrease in the severity of kidney injury in two models: AGT1 knockout mice (AGT1KO) in which hyperoxaluria is the result of an Agxt gene deficiency, and in AGT1KO mice challenged with ethylene glycol (EG).	Oxalates	74-81	alanine-glyoxylate aminotransferase	Mus musculus	205-209
19839830-8	2009	PJ was found to have inhibitory effects on renal tubular cell injury and oxidative stress caused by oxalate crystals by reducing ROS, iNOS, p38-MAPK, and NF-kB expression.	Oxalates	100-107	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	154-159
18982322-2	2008	Primary hyperoxaluria type 2 (PH2) is a rare inherited disease caused by overproduction of endogenous oxalate due to mutations in the glyoxylate/hydroxypyruvate reductase (GRHPR) gene.	Oxalates	102-109	glyoxylate and hydroxypyruvate reductase	Homo sapiens	145-170
18982322-2	2008	Primary hyperoxaluria type 2 (PH2) is a rare inherited disease caused by overproduction of endogenous oxalate due to mutations in the glyoxylate/hydroxypyruvate reductase (GRHPR) gene.	Oxalates	102-109	glyoxylate and hydroxypyruvate reductase	Homo sapiens	172-177
18985333-3	2008	In the KO model of PH1, only male mice develop renal stones, suggesting that the sex difference may affect both oxalate production and stone formation.	Oxalates	112-119	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	19-22
18505365-3	2008	In this study, we estimated OPN function in early morphological changes of calcium oxalate crystals using OPN knockout mice: 100 mg/kg glyoxylate was intra-abdominally injected into wildtype mice (WT) and OPN knockout mice (KO) for a week, and 24-h urine oxalate excretion showed no significant difference between WT and KO.	Oxalates	83-90	secreted phosphoprotein 1	Mus musculus	28-31
18785115-4	2008	Oxalate crystal deposition was observed in the stroma and the tumor focally resembled translocation type (TFE3) RCC.	Oxalates	0-7	transcription factor binding to IGHM enhancer 3	Homo sapiens	106-110
18721209-0	2008	NF-kappaB activation in renal tubular epithelial cells by oxalate stimulation.	Oxalates	58-65	nuclear factor kappa B subunit 1	Homo sapiens	0-9
18721209-3	2008	In the present study, we demonstrated that oxalate induces OPN expression by activating NF-kappaB in renal tubular cells.	Oxalates	43-50	secreted phosphoprotein 1	Homo sapiens	59-62
18721209-3	2008	In the present study, we demonstrated that oxalate induces OPN expression by activating NF-kappaB in renal tubular cells.	Oxalates	43-50	nuclear factor kappa B subunit 1	Homo sapiens	88-97
18721209-8	2008	RESULTS: As a result of oxalate stimulation, the amount of p65 subunit in the nucleus increased significantly (P < 0.05), and NAC significantly inhibited the translocation of p65 into the nucleus (P < 0.05).	Oxalates	24-31	RELA proto-oncogene, NF-kB subunit	Homo sapiens	59-62
18721209-8	2008	RESULTS: As a result of oxalate stimulation, the amount of p65 subunit in the nucleus increased significantly (P < 0.05), and NAC significantly inhibited the translocation of p65 into the nucleus (P < 0.05).	Oxalates	24-31	X-linked Kx blood group	Homo sapiens	129-132
18721209-8	2008	RESULTS: As a result of oxalate stimulation, the amount of p65 subunit in the nucleus increased significantly (P < 0.05), and NAC significantly inhibited the translocation of p65 into the nucleus (P < 0.05).	Oxalates	24-31	RELA proto-oncogene, NF-kB subunit	Homo sapiens	178-181
18615209-0	2008	Assembly of a two-dimensional oxalate-bridged heterometallic Co(II)(3)Cr(III)(2) coordination polymer.	Oxalates	30-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
18937599-2	2008	Oxalate and other stone precursors have been shown to increase IL-6 production in proximal tubular epithelial cells in vitro.	Oxalates	0-7	interleukin 6	Homo sapiens	63-67
18295252-2	2008	Recently we successfully purified trefoil factor 1 from human urine and used an oxalate depletion assay to indirectly infer its inhibitory activity against calcium oxalate crystal growth.	Oxalates	80-87	trefoil factor 1	Homo sapiens	34-50
18523430-7	2008	Oxalate stimulates the uptake of chloride, water, and sodium by the proximal tubule through the exchange of oxalate for sulfate or chloride via the solute carrier SLC26A6.	Oxalates	0-7	solute carrier family 26 member 6	Homo sapiens	163-170
18523430-7	2008	Oxalate stimulates the uptake of chloride, water, and sodium by the proximal tubule through the exchange of oxalate for sulfate or chloride via the solute carrier SLC26A6.	Oxalates	108-115	solute carrier family 26 member 6	Homo sapiens	163-170
18475180-9	2008	RESULTS: The procedure resulted in progressive replacement of the mutant host hepatocytes with the AGT-competent hepatocytes, leading to correction of urinary oxalate excretion.	Oxalates	159-166	alanine-glyoxylate aminotransferase	Mus musculus	99-102
18310129-0	2008	The role of SLC26A6-mediated chloride/oxalate exchange in causing susceptibility to nephrolithiasis.	Oxalates	38-45	solute carrier family 26 member 6	Homo sapiens	12-19
18174209-5	2008	Both transporters exhibit highly cooperative dependence of oxalate efflux rate on extracellular [Cl(-)], but whereas the K(1/2) for extracellular [Cl(-)] is only 8 mM for mouse slc26a6, that for human SLC26A6 is 62 mM.	Oxalates	59-66	solute carrier family 26, member 6	Mus musculus	177-184
18174209-5	2008	Both transporters exhibit highly cooperative dependence of oxalate efflux rate on extracellular [Cl(-)], but whereas the K(1/2) for extracellular [Cl(-)] is only 8 mM for mouse slc26a6, that for human SLC26A6 is 62 mM.	Oxalates	59-66	solute carrier family 26 member 6	Homo sapiens	201-208
18174209-7	2008	Human SLC26A6 variant V185M exhibits altered [Cl(-)] dependence and reduced rates of oxalate/Cl(-) exchange.	Oxalates	85-92	solute carrier family 26 member 6	Homo sapiens	6-13
18174209-8	2008	Whereas mouse slc26a6 mediates bidirectional electrogenic oxalate/Cl(-) exchange, human SLC26A6-mediated oxalate transport appears to be electroneutral.	Oxalates	58-65	solute carrier family 26, member 6	Mus musculus	14-21
18174209-8	2008	Whereas mouse slc26a6 mediates bidirectional electrogenic oxalate/Cl(-) exchange, human SLC26A6-mediated oxalate transport appears to be electroneutral.	Oxalates	105-112	solute carrier family 26 member 6	Homo sapiens	88-95
18174209-9	2008	We hypothesize that the low extracellular Cl(-) affinity and apparent electroneutrality of oxalate efflux characterizing human SLC26A6 may partially explain the high human susceptibility to nephrolithiasis relative to that of mouse.	Oxalates	91-98	solute carrier family 26 member 6	Homo sapiens	127-134
18174209-0	2008	Species differences in Cl- affinity and in electrogenicity of SLC26A6-mediated oxalate/Cl- exchange correlate with the distinct human and mouse susceptibilities to nephrolithiasis.	Oxalates	79-86	solute carrier family 26 member 6	Homo sapiens	62-69
18174209-3	2008	Here we extend our earlier demonstration of different anion selectivities of the orthologous mouse and human SLC26A6 polypeptides to investigate the correlation between species-specific differences in SLC26A6 oxalate/anion exchange properties as expressed in Xenopus oocytes and in reported nephrolithiasis susceptibility.	Oxalates	209-216	solute carrier family 26 member 6	Homo sapiens	201-208
18172632-0	2008	Oxalate exposure provokes HSP 70 response in LLC-PK1 cells, a line of renal epithelial cells: protective role of HSP 70 against oxalate toxicity.	Oxalates	0-7	heat shock 70 kDa protein 6	Sus scrofa	26-32
18215067-1	2008	Human glycolate oxidase (GO) catalyzes the FMN-dependent oxidation of glycolate to glyoxylate and glyoxylate to oxalate, a key metabolite in kidney stone formation.	Oxalates	112-119	hydroxyacid oxidase 2	Homo sapiens	6-23
18215067-1	2008	Human glycolate oxidase (GO) catalyzes the FMN-dependent oxidation of glycolate to glyoxylate and glyoxylate to oxalate, a key metabolite in kidney stone formation.	Oxalates	112-119	hydroxyacid oxidase 2	Homo sapiens	25-27
18215067-1	2008	Human glycolate oxidase (GO) catalyzes the FMN-dependent oxidation of glycolate to glyoxylate and glyoxylate to oxalate, a key metabolite in kidney stone formation.	Oxalates	112-119	formin 1	Homo sapiens	43-46
18215067-8	2008	The kinetic parameters for the oxidation of glycolate, glyoxylate, and 2-hydroxy octanoate indicate that the oxidation of glycolate to glyoxylate is the primary reaction catalyzed by GO, while the oxidation of glyoxylate to oxalate is most likely not relevant under normal conditions.	Oxalates	224-231	hydroxyacid oxidase 2	Homo sapiens	183-185
18172632-5	2008	Oxalate exposure selectively increased the levels of mRNA encoding IEGs c-myc and c-jun as well as stress protein HSP 70.	Oxalates	0-7	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	72-77
18172632-5	2008	Oxalate exposure selectively increased the levels of mRNA encoding IEGs c-myc and c-jun as well as stress protein HSP 70.	Oxalates	0-7	transcription factor Jun	Sus scrofa	82-87
18172632-0	2008	Oxalate exposure provokes HSP 70 response in LLC-PK1 cells, a line of renal epithelial cells: protective role of HSP 70 against oxalate toxicity.	Oxalates	0-7	heat shock 70 kDa protein 6	Sus scrofa	113-119
18172632-5	2008	Oxalate exposure selectively increased the levels of mRNA encoding IEGs c-myc and c-jun as well as stress protein HSP 70.	Oxalates	0-7	heat shock 70 kDa protein 6	Sus scrofa	114-120
18172632-0	2008	Oxalate exposure provokes HSP 70 response in LLC-PK1 cells, a line of renal epithelial cells: protective role of HSP 70 against oxalate toxicity.	Oxalates	128-135	heat shock 70 kDa protein 6	Sus scrofa	113-119
18172632-8	2008	Moreover, we show that prior induction of HSP 70 by mild hypertonic exposure protected the cells from oxalate toxicity.	Oxalates	102-109	heat shock 70 kDa protein 6	Sus scrofa	42-48
18172632-9	2008	To the best of our knowledge this is the first study to demonstrate rapid IEG response and delayed heat-shock response to oxalate toxicity and protective role of HSP 70 against oxalate toxicity to renal epithelial cells.	Oxalates	177-184	heat shock 70 kDa protein 6	Sus scrofa	162-168
18172632-10	2008	Oxalate, a metabolic end product, induces IEGs c-myc and c-jun and a delayed HSP 70 expression; While IEG expression may regulate additional genetic responses to oxalate, increased HSP 70 expression would serve an early protective role during oxalate stress.	Oxalates	0-7	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	47-52
18172632-10	2008	Oxalate, a metabolic end product, induces IEGs c-myc and c-jun and a delayed HSP 70 expression; While IEG expression may regulate additional genetic responses to oxalate, increased HSP 70 expression would serve an early protective role during oxalate stress.	Oxalates	0-7	transcription factor Jun	Sus scrofa	57-62
18172632-10	2008	Oxalate, a metabolic end product, induces IEGs c-myc and c-jun and a delayed HSP 70 expression; While IEG expression may regulate additional genetic responses to oxalate, increased HSP 70 expression would serve an early protective role during oxalate stress.	Oxalates	0-7	heat shock 70 kDa protein 6	Sus scrofa	77-83
18172632-10	2008	Oxalate, a metabolic end product, induces IEGs c-myc and c-jun and a delayed HSP 70 expression; While IEG expression may regulate additional genetic responses to oxalate, increased HSP 70 expression would serve an early protective role during oxalate stress.	Oxalates	0-7	heat shock 70 kDa protein 6	Sus scrofa	181-187
18155525-1	2008	Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive metabolic disorder resulting in the overproduction of plasma oxalate.	Oxalates	126-133	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	30-33
18227000-5	2008	The defect of renal ammoniogenesis armature by the resistance of the renal cells to insulin involves a urinary hyperacidity which supports the crystallization of the uric acid responsible for the formation of uric or mixed uric acid/oxalate stones.	Oxalates	233-240	insulin	Homo sapiens	84-91
18155525-9	2008	The diagnosis of PH1 is more challenging in patients with ESRD, for whom urinary oxalate levels are often normal or only modestly increased because of decreased glomerular filtration, and recurrent nephrolithiasis is no longer the dominant clinical feature.	Oxalates	81-88	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	17-20
18981681-0	2008	Increased expression of heparan sulfate proteoglycan on the cultured renal epithelial cells during oxalate exposure.	Oxalates	99-106	CD44 molecule (Indian blood group)	Homo sapiens	24-52
17669354-1	2007	Glycolate oxidase, an FMN-dependent peroxisomal oxidase, plays an important role in plants, related to photorespiration, and in animals, where it can contribute to the production of oxalate with formation of kidney stones.	Oxalates	182-189	hydroxyacid oxidase 2	Homo sapiens	0-17
18981681-8	2008	Increased syndecan-1 mRNA expression and production of core proteins were confirmed in KIC-synd-1 cells during oxalate exposure.	Oxalates	111-118	syndecan 1	Canis lupus familiaris	10-20
17151144-5	2007	PKC activation inhibited Slc26a6-mediated Cl/formate exchange, Cl/oxalate exchange, and Cl/Cl exchange to a similar extent.	Oxalates	66-73	protein kinase C, delta	Mus musculus	0-3
17644632-8	2007	Indirect evidence is provided suggesting that the sensitivity of the rib4Delta mutant, a riboflavin auxotroph, is due to oxalate-mediated interference with riboflavin uptake by the putative monocarboxylate transporter Mch5.	Oxalates	121-128	Mch5p	Saccharomyces cerevisiae S288C	218-222
17693766-4	2007	RECENT FINDINGS: In proximal tubules, Slc26a1 (Sat-1) mediates sulfate and oxalate transport across the basolateral membrane, while Slc26a6 (CFEX, Pat-1) mediates a variety of anion exchange at the apical membrane to facilitate transcellular sodium chloride absorption.	Oxalates	75-82	solute carrier family 26 (sulfate transporter), member 1	Mus musculus	38-45
17693766-4	2007	RECENT FINDINGS: In proximal tubules, Slc26a1 (Sat-1) mediates sulfate and oxalate transport across the basolateral membrane, while Slc26a6 (CFEX, Pat-1) mediates a variety of anion exchange at the apical membrane to facilitate transcellular sodium chloride absorption.	Oxalates	75-82	spermidine/spermine N1-acetyl transferase 1	Mus musculus	47-52
17693766-5	2007	Targeted deletion of murine Slc26a6 leads to intestinal hyperabsorption of oxalate, hyperoxaluria, and kidney stones.	Oxalates	75-82	solute carrier family 26, member 6	Mus musculus	28-35
17509359-1	2007	PURPOSE: Matrix Gla protein, a potent calcification inhibitor in arterial vessels, is also expressed in the kidney and is up-regulated following the administration of ethylene glycol, a precursor of oxalate.	Oxalates	199-206	matrix Gla protein	Homo sapiens	9-27
17495409-3	2007	This proposed method has excellent reproducibility, and was applied to recovery tests of oxalate ion in tap water and human urine; the results were satisfactory.	Oxalates	89-96	nuclear RNA export factor 1	Homo sapiens	104-107
17442754-5	2007	Using patch-clamp recordings, we show that these prestin orthologs, but not mammalian prestin, generate robust transport currents in the presence of the divalent anions sulfate or oxalate.	Oxalates	180-187	solute carrier family 26 member 5	Homo sapiens	49-56
17442754-7	2007	The dependence of transport equilibrium potentials on sulfate and chloride concentration gradients shows that the prestin orthologs are electrogenic antiporters, exchanging sulfate or oxalate for chloride in a strictly coupled manner with a 1:1 stoichiometry.	Oxalates	184-191	solute carrier family 26 member 5	Homo sapiens	114-121
17151144-10	2007	The physiological significance of these findings was supported by the observation that PKC activation inhibited mouse duodenal oxalate secretion, an effect blocked by rottlerin.	Oxalates	127-134	protein kinase C, delta	Mus musculus	87-90
16883319-0	2006	Essential roles of CFEX-mediated Cl(-)-oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis.	Oxalates	39-46	solute carrier family 26, member 6	Mus musculus	19-23
17210574-1	2007	Oxalate oxidase (EC 1.2.3.4) catalyzes the oxidative cleavage of oxalate to carbon dioxide and hydrogen peroxide.	Oxalates	65-72	LOC548260	Hordeum vulgare	0-15
17239470-4	2007	The release of iron from Tf is inhibited by replacing the synergistic carbonate anion with oxalate.	Oxalates	91-98	transferrin	Homo sapiens	25-27
17239470-8	2007	Conjugate IC(50) values were determined to be 0.06 nM for the oxalate Tf conjugate vs. 0.22 nM for the native Tf conjugate.	Oxalates	62-69	transferrin	Homo sapiens	70-72
17027096-2	2006	PH1 is characterized by excessive synthesis and excretion of the metabolic end-product oxalate and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.	Oxalates	87-94	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	0-3
17110443-1	2006	Mutations in the alanine-glyoxylate amino transferase gene (AGXT) are responsible for primary hyperoxaluria type I, a rare disease characterized by excessive hepatic oxalate production that leads to renal failure.	Oxalates	166-173	alanine-glyoxylate aminotransferase	Mus musculus	60-64
17110443-6	2006	Hepatic expression of human AGT1, the protein encoded by AGXT, by adenoviral vector-mediated gene transfer in Agxt(-/-) mice normalized urinary oxalate excretion and prevented oxalate crystalluria.	Oxalates	144-151	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	28-32
17110443-6	2006	Hepatic expression of human AGT1, the protein encoded by AGXT, by adenoviral vector-mediated gene transfer in Agxt(-/-) mice normalized urinary oxalate excretion and prevented oxalate crystalluria.	Oxalates	144-151	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	57-61
17350229-7	2007	In contrast, anaerobic oxalate consumption was negligible in suspensions prepared with acidic soils (<pH 4.2) collected from three different forest field sites.	Oxalates	23-30	prolyl 4-hydroxylase, transmembrane	Homo sapiens	105-109
17024101-8	2007	PLB silencing was associated with a marked increase in ATP-dependent oxalate-supported Ca(2+) uptake at 0.34 microM of free Ca(2+), and rapid loss of responsiveness to protein kinase A-dependent stimulation of Ca(2+) uptake was maintained until day 7.	Oxalates	69-76	phospholamban	Rattus norvegicus	0-3
16883319-6	2006	Measurements of transport in renal brush border vesicles isolated from CFEX-null mice demonstrated that CFEX primarily mediates Cl(-)-oxalate exchange rather than Cl(-)-formate exchange.	Oxalates	134-141	solute carrier family 26, member 6	Mus musculus	104-108
16883319-7	2006	Microperfusion studies in CFEX-null mice revealed that CFEX plays an essential role in mediating oxalate-dependent NaCl absorption in the proximal tubule.	Oxalates	97-104	solute carrier family 26, member 6	Mus musculus	26-30
16883319-7	2006	Microperfusion studies in CFEX-null mice revealed that CFEX plays an essential role in mediating oxalate-dependent NaCl absorption in the proximal tubule.	Oxalates	97-104	solute carrier family 26, member 6	Mus musculus	55-59
16883319-9	2006	The etiology of hyperoxaluria in CFEX-null mice was observed to be a defect in oxalate secretion in the intestine, leading to enhanced net absorption of ingested oxalate and elevation of plasma oxalate.	Oxalates	79-86	solute carrier family 26, member 6	Mus musculus	33-37
16883319-9	2006	The etiology of hyperoxaluria in CFEX-null mice was observed to be a defect in oxalate secretion in the intestine, leading to enhanced net absorption of ingested oxalate and elevation of plasma oxalate.	Oxalates	162-169	solute carrier family 26, member 6	Mus musculus	33-37
16883319-9	2006	The etiology of hyperoxaluria in CFEX-null mice was observed to be a defect in oxalate secretion in the intestine, leading to enhanced net absorption of ingested oxalate and elevation of plasma oxalate.	Oxalates	162-169	solute carrier family 26, member 6	Mus musculus	33-37
16922352-2	2006	The deficiency is due to mutations in the AGXT gene, located on chromosome 2q37.3, and results in the conversion of glyoxylate to oxalate.	Oxalates	130-137	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	42-46
16925768-0	2006	Oxalate ions and calcium oxalate crystal-induced up-regulation of osteopontin and monocyte chemoattractant protein-1 in renal fibroblasts.	Oxalates	0-7	secreted phosphoprotein 1	Homo sapiens	66-77
16925768-0	2006	Oxalate ions and calcium oxalate crystal-induced up-regulation of osteopontin and monocyte chemoattractant protein-1 in renal fibroblasts.	Oxalates	0-7	C-C motif chemokine ligand 2	Homo sapiens	82-116
16736438-10	2006	In SLC26A6 null mice the effects of formate or oxalate to stimulate NaCl absorption in microperfused proximal tubules are reduced or absent, respectively, but there is no change in baseline NaCl absorption measured in the absence of formate and oxalate.	Oxalates	47-54	solute carrier family 26, member 6	Mus musculus	3-10
16373425-0	2006	Ileal oxalate absorption and urinary oxalate excretion are enhanced in Slc26a6 null mice.	Oxalates	6-13	solute carrier family 26, member 6	Mus musculus	71-78
16373425-0	2006	Ileal oxalate absorption and urinary oxalate excretion are enhanced in Slc26a6 null mice.	Oxalates	37-44	solute carrier family 26, member 6	Mus musculus	71-78
16373425-2	2006	To assess the contribution of the putative anion transporter (PAT)1 (Slc26a6) to transepithelial oxalate transport, we compared the unidirectional and net fluxes of oxalate across isolated, short-circuited segments of the distal ileum of wild-type (WT) mice and Slc26a6 null mice [knockout (KO)].	Oxalates	97-104	solute carrier family 26, member 6	Mus musculus	62-67
16373425-2	2006	To assess the contribution of the putative anion transporter (PAT)1 (Slc26a6) to transepithelial oxalate transport, we compared the unidirectional and net fluxes of oxalate across isolated, short-circuited segments of the distal ileum of wild-type (WT) mice and Slc26a6 null mice [knockout (KO)].	Oxalates	97-104	solute carrier family 26, member 6	Mus musculus	69-76
16373425-2	2006	To assess the contribution of the putative anion transporter (PAT)1 (Slc26a6) to transepithelial oxalate transport, we compared the unidirectional and net fluxes of oxalate across isolated, short-circuited segments of the distal ileum of wild-type (WT) mice and Slc26a6 null mice [knockout (KO)].	Oxalates	165-172	solute carrier family 26, member 6	Mus musculus	62-67
16373425-9	2006	We conclude that PAT1 is DIDS sensitive and mediates a significant fraction of oxalate efflux across the apical membrane in exchange for Cl(-); as such, PAT1 represents a major apical membrane pathway mediating J(sm)(Ox).	Oxalates	79-86	solute carrier family 26, member 6	Mus musculus	17-21
16373425-9	2006	We conclude that PAT1 is DIDS sensitive and mediates a significant fraction of oxalate efflux across the apical membrane in exchange for Cl(-); as such, PAT1 represents a major apical membrane pathway mediating J(sm)(Ox).	Oxalates	79-86	solute carrier family 26, member 6	Mus musculus	153-157
16532010-4	2006	Among its transport activities, SLC26A6 mediates Cl(-)-oxalate exchange.	Oxalates	55-62	solute carrier family 26, member 6	Mus musculus	32-39
16532010-6	2006	Slc26a6-null mice have significant hyperoxaluria and elevation in plasma oxalate concentration that is greatly attenuated by dietary oxalate restriction.	Oxalates	73-80	solute carrier family 26, member 6	Mus musculus	0-7
16532010-6	2006	Slc26a6-null mice have significant hyperoxaluria and elevation in plasma oxalate concentration that is greatly attenuated by dietary oxalate restriction.	Oxalates	133-140	solute carrier family 26, member 6	Mus musculus	0-7
16532010-7	2006	In vitro flux studies indicated that mice lacking Slc26a6 have a defect in intestinal oxalate secretion resulting in enhanced net absorption of oxalate.	Oxalates	86-93	solute carrier family 26, member 6	Mus musculus	50-57
16532010-7	2006	In vitro flux studies indicated that mice lacking Slc26a6 have a defect in intestinal oxalate secretion resulting in enhanced net absorption of oxalate.	Oxalates	144-151	solute carrier family 26, member 6	Mus musculus	50-57
16532010-8	2006	We conclude that the anion exchanger SLC26A6 has a major constitutive role in limiting net intestinal absorption of oxalate, thereby preventing hyperoxaluria and calcium oxalate urolithiasis.	Oxalates	116-123	solute carrier family 26, member 6	Mus musculus	37-44
16736438-11	2006	These findings suggest that SLC26A6 primarily mediates proximal tubule Cl- absorption by Cl--oxalate exchange and Cl--formate exchange rather than by Cl--HCO3- or Cl--OH-exchange.	Oxalates	93-100	solute carrier family 26, member 6	Mus musculus	28-35
16834654-2	2006	We recently reported that FN has a protective effect against injury of renal tubular cells by exposure to oxalate and calcium oxalate (CaOX) crystals and inhibits the adhesion of CaOX crystals to renal tubular cells.	Oxalates	106-113	fibronectin 1	Canis lupus familiaris	26-28
16479391-7	2006	Oxalate excretion was significantly elevated in all KOx rats (P < or = 0.005).	Oxalates	0-7	NADPH oxidase 4	Homo sapiens	52-55
16570061-0	2006	A key stone cop regulates oxalate homeostasis.	Oxalates	26-33	caspase recruitment domain family member 16	Homo sapiens	12-15
16309382-6	2006	These results are compatible with the findings in PH1 and PH2, in which AGT and GR/HPR deficiencies lead to increased oxalate synthesis, due to the failure to detoxify its immediate precursor glyoxylate.	Oxalates	118-125	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	50-53
16309382-6	2006	These results are compatible with the findings in PH1 and PH2, in which AGT and GR/HPR deficiencies lead to increased oxalate synthesis, due to the failure to detoxify its immediate precursor glyoxylate.	Oxalates	118-125	glyoxylate and hydroxypyruvate reductase	Homo sapiens	58-61
16309382-6	2006	These results are compatible with the findings in PH1 and PH2, in which AGT and GR/HPR deficiencies lead to increased oxalate synthesis, due to the failure to detoxify its immediate precursor glyoxylate.	Oxalates	118-125	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	72-75
16307291-0	2005	Oxalate induced expression of monocyte chemoattractant protein-1 (MCP-1) in HK-2 cells involves reactive oxygen species.	Oxalates	0-7	chemokine (C-C motif) ligand 2	Mus musculus	30-64
16477383-8	2006	Administering phycocyanin after oxalate treatment significantly increased catalase and glucose-6-phosphate dehydrogenase activity (p < 0.001) in RBC lysate suggesting phycocyanin as a free radical quencher.	Oxalates	32-39	catalase	Rattus norvegicus	74-82
16477383-8	2006	Administering phycocyanin after oxalate treatment significantly increased catalase and glucose-6-phosphate dehydrogenase activity (p < 0.001) in RBC lysate suggesting phycocyanin as a free radical quencher.	Oxalates	32-39	glucose-6-phosphate dehydrogenase	Rattus norvegicus	87-120
16407047-2	2006	BRI is the ratio of the concentration of ionized calcium and the amount of oxalate that must be added to 200 ml urine to initiate crystallization.	Oxalates	75-82	integral membrane protein 2B	Homo sapiens	0-3
17120764-7	2006	But, whereas Cl-/oxalate exchange by mouse Slc26a6 was electrogenic, that mediated by human SLC26A6 appeared electroneutral.	Oxalates	17-24	solute carrier family 26, member 6	Mus musculus	43-50
17120765-3	2006	We reported that Slc26a6 functions as a Cl-/formate, Cl-/oxalate, Cl-/OH- and electrogenic Cl-/nHCO3- exchanger.	Oxalates	57-64	solute carrier family 26, member 6	Mus musculus	17-24
17120765-6	2006	Radioisotope uptakes in Xenopus oocytes indicate that Slc26a9 is a highly selective anion exchanger, transporting Cl- but neither formate, oxalate, nor SO42-.	Oxalates	139-146	solute carrier family 26, member 9	Mus musculus	54-61
17120766-8	2006	Microperfusion studies on SLC26A6 null mice demonstrated that SLC26A6 is essential for oxalate-dependent NaCl absorption but does not contribute to baseline transport, suggesting it primarily mediates Cl-/oxalate exchange rather than Cl--OH- or Cl-/HCO3- exchange in the proximal tubule.	Oxalates	87-94	solute carrier family 26, member 6	Mus musculus	62-69
17120766-8	2006	Microperfusion studies on SLC26A6 null mice demonstrated that SLC26A6 is essential for oxalate-dependent NaCl absorption but does not contribute to baseline transport, suggesting it primarily mediates Cl-/oxalate exchange rather than Cl--OH- or Cl-/HCO3- exchange in the proximal tubule.	Oxalates	205-212	solute carrier family 26, member 6	Mus musculus	62-69
16198644-10	2005	The potential roles of LDH isoforms and GRHPR in oxalate synthesis are discussed.	Oxalates	49-56	glyoxylate and hydroxypyruvate reductase	Homo sapiens	40-45
16307291-0	2005	Oxalate induced expression of monocyte chemoattractant protein-1 (MCP-1) in HK-2 cells involves reactive oxygen species.	Oxalates	0-7	chemokine (C-C motif) ligand 2	Mus musculus	66-71
16307291-2	2005	In the current study, we investigated the oxalate-induced injury and up-regulation of monocyte-chemoattractant protein-1 (MCP-1) in HK-2 cells, a proximal tubular epithelial cell line derived from normal human kidney.	Oxalates	42-49	chemokine (C-C motif) ligand 2	Mus musculus	122-127
16307291-7	2005	The MCP-1 mRNA increased following exposure to oxalate and was reduced upon treatment with free radical scavengers, catalase and superoxide dismutase.	Oxalates	47-54	chemokine (C-C motif) ligand 2	Mus musculus	4-9
16307291-7	2005	The MCP-1 mRNA increased following exposure to oxalate and was reduced upon treatment with free radical scavengers, catalase and superoxide dismutase.	Oxalates	47-54	catalase	Mus musculus	116-124
16307291-9	2005	To our knowledge, this is the first report of MCP-1 expression and its upregulation by oxalate exposure in HK-2 cells.	Oxalates	87-94	chemokine (C-C motif) ligand 2	Mus musculus	46-51
16370207-3	2005	The promotors (oxalate, calcium, uric acid, phosphates) and inhibitors (citrate, magnesium) are statistically significant between G1, G2 and G3, G2.	Oxalates	15-22	proline rich protein BstNI subfamily 3	Homo sapiens	130-147
16284878-1	2005	In primary hyperoxaluria the deficiency or mistargeting of hepatic alanine-glyoxylate aminotransferase (AGT) leads to the overproduction of oxalate resulting in hyperoxaluria and renal damage due to urolithiasis and/or nephrocalcinosis.	Oxalates	140-147	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	67-102
16284878-1	2005	In primary hyperoxaluria the deficiency or mistargeting of hepatic alanine-glyoxylate aminotransferase (AGT) leads to the overproduction of oxalate resulting in hyperoxaluria and renal damage due to urolithiasis and/or nephrocalcinosis.	Oxalates	140-147	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	104-107
16284883-2	2005	Oxalate exposure activates phospholipase A2 (PLA2), which increases two lipid signaling molecules, arachidonic acid and lysophosphatidylcholine (Lyso-PC).	Oxalates	0-7	phospholipase A2 group IB	Homo sapiens	27-43
16284883-2	2005	Oxalate exposure activates phospholipase A2 (PLA2), which increases two lipid signaling molecules, arachidonic acid and lysophosphatidylcholine (Lyso-PC).	Oxalates	0-7	phospholipase A2 group IB	Homo sapiens	45-49
16284883-3	2005	PLA2 inhibition blocks, whereas exogenous Lyso-PC or arachidonic acid reproduce many of the effects of oxalate on mitochondrial function, gene expression and cell viability, suggesting that PLA2 activation plays a role in mediating oxalate toxicity.	Oxalates	103-110	phospholipase A2 group IB	Homo sapiens	190-194
16284883-3	2005	PLA2 inhibition blocks, whereas exogenous Lyso-PC or arachidonic acid reproduce many of the effects of oxalate on mitochondrial function, gene expression and cell viability, suggesting that PLA2 activation plays a role in mediating oxalate toxicity.	Oxalates	232-239	phospholipase A2 group IB	Homo sapiens	190-194
16284883-8	2005	The present studies demonstrate that oxalate exposure upregulates cyclooxygenase-2, which catalyzes the rate-limiting step in the synthesis of prostanoids, compounds derived from arachidonic acid that can modify crystal binding and may also influence inflammation.	Oxalates	37-44	prostaglandin-endoperoxide synthase 2	Homo sapiens	66-82
16284883-9	2005	In addition, renal cell oxalate exposure promotes rapid degradation of IkappaBalpha, an endogenous inhibitor of the NF-kappaB transcription factor.	Oxalates	24-31	NFKB inhibitor alpha	Homo sapiens	71-83
15996096-5	2005	The X-ray structure of human hPKM2 complexed with Mg(2+), K(+), the inhibitor oxalate, and the allosteric activator fructose 1,6-bisphosphate (FBP) has been determined to a resolution of 2.82 A.	Oxalates	78-85	pyruvate kinase M1/2	Homo sapiens	29-34
15961223-2	2005	For ferrihydrite, the organic species increased %As(V) extraction in the order: acetate<oxalate<<citrate.	Oxalates	91-98	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	49-54
16141316-7	2005	Finally, we assayed CFEX functional activity as Cl-oxalate exchange in brush border membrane vesicles and oxalate-stimulated volume absorption in microperfused proximal tubules.	Oxalates	51-58	solute carrier family 26, member 6	Mus musculus	20-24
15840574-2	2005	One of the key enzymes in this pathway is glyoxylate reductase/hydroxypyruvate reductase (GRHPR) whose dysfunction in human causes primary hyperoxaluria type 2, a disease resulting in oxalate accumulation and formation of kidney stones.	Oxalates	184-191	glyoxylate and hydroxypyruvate reductase	Homo sapiens	42-62
16014026-0	2005	Oxalate stimulates IL-6 production in HK-2 cells, a line of human renal proximal tubular epithelial cells.	Oxalates	0-7	interleukin 6	Homo sapiens	19-23
16014026-5	2005	In the present study, we investigated the role of oxalate, a major constituent of calcium oxalate kidney stone disease, in the production of IL-6 in normal human HK-2 kidney cells.	Oxalates	50-57	interleukin 6	Homo sapiens	141-145
16014026-11	2005	Oxalate increased the secretion of IL-6 protein in HK-2 cells in a concentration-dependent fashion.	Oxalates	0-7	interleukin 6	Homo sapiens	35-39
16014026-12	2005	Oxalate exposure to HK-2 cells also induced transcriptional up-regulation of the IL-6 gene, as determined by the increased level of IL-6 mRNA expression following treatment with oxalate.	Oxalates	0-7	interleukin 6	Homo sapiens	81-85
16014026-12	2005	Oxalate exposure to HK-2 cells also induced transcriptional up-regulation of the IL-6 gene, as determined by the increased level of IL-6 mRNA expression following treatment with oxalate.	Oxalates	0-7	interleukin 6	Homo sapiens	132-136
16014026-12	2005	Oxalate exposure to HK-2 cells also induced transcriptional up-regulation of the IL-6 gene, as determined by the increased level of IL-6 mRNA expression following treatment with oxalate.	Oxalates	178-185	interleukin 6	Homo sapiens	81-85
16014026-12	2005	Oxalate exposure to HK-2 cells also induced transcriptional up-regulation of the IL-6 gene, as determined by the increased level of IL-6 mRNA expression following treatment with oxalate.	Oxalates	178-185	interleukin 6	Homo sapiens	132-136
16014026-13	2005	Moreover, the effects of oxalate on IL-6 expression were time- and concentration-dependent.	Oxalates	25-32	interleukin 6	Homo sapiens	36-40
16014026-14	2005	This is the first report demonstrating the regulation of IL-6 by oxalate.	Oxalates	65-72	interleukin 6	Homo sapiens	57-61
16014026-15	2005	CONCLUSION: This study provides the first direct evidence that oxalate up-regulates the expression and secretion of IL-6 in renal epithelial cells.	Oxalates	63-70	interleukin 6	Homo sapiens	116-120
15840574-2	2005	One of the key enzymes in this pathway is glyoxylate reductase/hydroxypyruvate reductase (GRHPR) whose dysfunction in human causes primary hyperoxaluria type 2, a disease resulting in oxalate accumulation and formation of kidney stones.	Oxalates	184-191	glyoxylate and hydroxypyruvate reductase	Homo sapiens	63-88
15840574-2	2005	One of the key enzymes in this pathway is glyoxylate reductase/hydroxypyruvate reductase (GRHPR) whose dysfunction in human causes primary hyperoxaluria type 2, a disease resulting in oxalate accumulation and formation of kidney stones.	Oxalates	184-191	glyoxylate and hydroxypyruvate reductase	Homo sapiens	90-95
15840574-5	2005	Consistent with these observations, mice deficient in PPARalpha present higher plasma levels of oxalate in comparison with their wild type counterparts.	Oxalates	96-103	peroxisome proliferator activated receptor alpha	Mus musculus	54-63
15840574-6	2005	As expected, the administration of a PPARalpha ligand (Wy-14,643) reduces the plasma oxalate levels.	Oxalates	85-92	peroxisome proliferator activated receptor alpha	Mus musculus	37-46
15961946-1	2005	BACKGROUND/AIMS: Primary hyperoxaluria type 1 (PH1) is caused by the deficiency of the liver enzyme alanine:glyoxylate aminotransferase which results in increased synthesis and excretion of oxalate.	Oxalates	190-197	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	47-50
15909602-8	2005	To the best of our knowledge, our patient represents the first case in the literature describing the association between the oxalate deposition and EPO resistance.	Oxalates	125-132	erythropoietin	Homo sapiens	148-151
15533056-6	2005	Oxalate treatment (500 microM) resulted in a time- and dose-dependent induction of A1M protein in LLC-PK1 cells.	Oxalates	0-7	alpha-1-microglobulin/bikunin precursor	Sus scrofa	83-86
15700199-5	2005	Oxalate-dependent SR Ca(2+) uptake and expression of SERCA 2A, PLB, phosphorylated PLB at serine 16 (PLB-Ser) and threonine 17 (PLB-Thr), RR, and NCX were determined.	Oxalates	0-7	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Canis lupus familiaris	53-61
15755756-0	2005	Diphenyleneiodium (DPI) reduces oxalate ion- and calcium oxalate monohydrate and brushite crystal-induced upregulation of MCP-1 in NRK 52E cells.	Oxalates	32-39	chemokine (C-C motif) ligand 2	Mus musculus	122-127
15755756-1	2005	BACKGROUND: Our earlier studies have demonstrated upregulation of monocyte chemoattractant protein-1 (MCP-1) in NRK52E rat renal epithelial cells by exposure to oxalate (Ox) ions and crystals of calcium oxalate monohydrate (COM) or the brushite (Br) form of calcium phosphate.	Oxalates	161-168	chemokine (C-C motif) ligand 2	Mus musculus	66-100
15755756-1	2005	BACKGROUND: Our earlier studies have demonstrated upregulation of monocyte chemoattractant protein-1 (MCP-1) in NRK52E rat renal epithelial cells by exposure to oxalate (Ox) ions and crystals of calcium oxalate monohydrate (COM) or the brushite (Br) form of calcium phosphate.	Oxalates	161-168	chemokine (C-C motif) ligand 2	Mus musculus	102-107
15759146-8	2005	The toxic effect of oxalate on HK-2 cells was considered to occur through apoptosis, as suggested by the increase of caspase-3 activity.	Oxalates	20-27	caspase 3	Homo sapiens	117-126
15759146-10	2005	Bax and caspase-9 protein expression increased significantly as oxalate concentrations increased, but Bcl-2 protein expression decreased.	Oxalates	64-71	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
15759146-10	2005	Bax and caspase-9 protein expression increased significantly as oxalate concentrations increased, but Bcl-2 protein expression decreased.	Oxalates	64-71	caspase 9	Homo sapiens	8-17
15548529-4	2005	Four human SLC26A6 polypeptide variants each exhibited rates of bidirectional [(14)C]oxalate flux, Cl(-)/HCO(3)(-) exchange, and Cl(-)/OH(-) exchange nearly equivalent to those of mouse slc26a6.	Oxalates	85-92	solute carrier family 26 member 6	Homo sapiens	11-18
15548529-10	2005	In contrast, whereas Cl(-)/oxalate exchange by mouse slc26a6 was electrogenic, that mediated by human SLC26A6 appeared electroneutral.	Oxalates	27-34	solute carrier family 26, member 6	Mus musculus	53-60
15548529-12	2005	The human SLC26A6 polypeptide variants SLC26A6c and SLC26A6d were inactive as transporters of oxalate, sulfate, and chloride.	Oxalates	94-101	solute carrier family 26 member 6	Homo sapiens	10-17
15548529-12	2005	The human SLC26A6 polypeptide variants SLC26A6c and SLC26A6d were inactive as transporters of oxalate, sulfate, and chloride.	Oxalates	94-101	solute carrier family 26 member 6	Homo sapiens	39-46
15664815-3	2005	The cytosolic isozyme hCA I was strongly activated by acetate, oxalate, pyruvate, l-lactate, and citrate (K(A) around 0.1 microM), whereas formate, malonate, malate, and benzoate were weaker activators (K(A) in the range 0.1-1mM).	Oxalates	63-70	carbonic anhydrase 1	Homo sapiens	22-27
15664815-5	2005	The membrane-associated isozyme hCA IV was the most sensitive to inhibition by carboxylates, showing a K(I) of 99 nM for citrate and oxalate, of 2.8 microM for malonate and of 14.5 microM for pyruvate among others.	Oxalates	133-140	carbonic anhydrase 4	Homo sapiens	32-38
15574486-2	2005	Modes of transport mediated by SLC26A6 include Cl-/formate exchange, Cl-/HCO3- exchange, and Cl-/oxalate exchange.	Oxalates	97-104	solute carrier family 26, member 6	Mus musculus	31-38
15574486-10	2005	We conclude that Slc26a6 mediates oxalate-stimulated NaCl absorption, contributes to apical membrane Cl-/base exchange in the kidney proximal tubule, and also plays an important role in HCO3- secretion in the duodenum.	Oxalates	34-41	solute carrier family 26, member 6	Mus musculus	17-24
15624128-3	2005	With respect to the centers of gravity of the oxalate and carbonate anions, respectively, the crystal structures of all known alkali-metal oxalates and carbonates belong to the AlB2 family, and adopt either the AlB2 or the Ni2In arrangement depending on the size of the cation and the temperature.	Oxalates	46-53	afamin	Homo sapiens	177-181
15700199-5	2005	Oxalate-dependent SR Ca(2+) uptake and expression of SERCA 2A, PLB, phosphorylated PLB at serine 16 (PLB-Ser) and threonine 17 (PLB-Thr), RR, and NCX were determined.	Oxalates	0-7	phospholamban	Canis lupus familiaris	63-66
15700199-5	2005	Oxalate-dependent SR Ca(2+) uptake and expression of SERCA 2A, PLB, phosphorylated PLB at serine 16 (PLB-Ser) and threonine 17 (PLB-Thr), RR, and NCX were determined.	Oxalates	0-7	phospholamban	Canis lupus familiaris	83-86
15700199-5	2005	Oxalate-dependent SR Ca(2+) uptake and expression of SERCA 2A, PLB, phosphorylated PLB at serine 16 (PLB-Ser) and threonine 17 (PLB-Thr), RR, and NCX were determined.	Oxalates	0-7	phospholamban	Canis lupus familiaris	83-86
15700199-5	2005	Oxalate-dependent SR Ca(2+) uptake and expression of SERCA 2A, PLB, phosphorylated PLB at serine 16 (PLB-Ser) and threonine 17 (PLB-Thr), RR, and NCX were determined.	Oxalates	0-7	phospholamban	Canis lupus familiaris	83-86
15956810-1	2005	BACKGROUND: The anion transporters SLC26A6 (PAT1) and SLC26A7, transporting at least chloride, oxalate, sulfate and bicarbonate, show a distinct expression and function in different mammalian species.	Oxalates	95-102	solute carrier family 26 member 6	Homo sapiens	35-42
15956810-1	2005	BACKGROUND: The anion transporters SLC26A6 (PAT1) and SLC26A7, transporting at least chloride, oxalate, sulfate and bicarbonate, show a distinct expression and function in different mammalian species.	Oxalates	95-102	amyloid beta precursor protein binding protein 2	Homo sapiens	44-48
15956810-1	2005	BACKGROUND: The anion transporters SLC26A6 (PAT1) and SLC26A7, transporting at least chloride, oxalate, sulfate and bicarbonate, show a distinct expression and function in different mammalian species.	Oxalates	95-102	solute carrier family 26 member 7	Homo sapiens	54-61
15496160-2	2004	Oxalate toxicity is mediated via generation of reactive oxygen species (ROS) in a process that depends at least in part upon lipid signaling molecules that are generated through membrane events that culminate in phospholipase A2 (PLA2) activation.	Oxalates	0-7	phospholipase A2 group IB	Canis lupus familiaris	212-228
15496160-2	2004	Oxalate toxicity is mediated via generation of reactive oxygen species (ROS) in a process that depends at least in part upon lipid signaling molecules that are generated through membrane events that culminate in phospholipase A2 (PLA2) activation.	Oxalates	0-7	phospholipase A2 group IB	Canis lupus familiaris	230-234
15496160-6	2004	Additional studies asked whether oxalate or lipids produced by PLA2 activation promoted ROS formation in isolated renal mitochondria.	Oxalates	33-40	phospholipase A2 group IB	Canis lupus familiaris	63-67
15496160-7	2004	RESULTS: Oxalate exposure decreased MDCK cell DeltaPsim within 30 minutes, a response attenuated by arachidonyl trifluoromethyl ketone (AACOCF3), an inhibitor of cytosolic PLA2 (cPLA2).	Oxalates	9-16	phospholipase A2 group IB	Canis lupus familiaris	172-176
15496160-10	2004	CONCLUSION: These studies suggest that lipid signaling molecules released after oxalate-induced PLA2 activation trigger marked, rapid changes in mitochondrial function that may mediate toxicity in renal epithelial cells.	Oxalates	80-87	phospholipase A2 group IB	Canis lupus familiaris	96-100
15480454-4	2004	For oxalate, malonate, benzoate and dibenzoate anions only the beta2 constants could be obtained.	Oxalates	4-11	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	63-68
15229103-0	2004	Oxalate inhibits renal proximal tubule cell proliferation via oxidative stress, p38 MAPK/JNK, and cPLA2 signaling pathways.	Oxalates	0-7	cytosolic phospholipase A2	Oryctolagus cuniculus	98-103
15229103-8	2004	Oxalate stimulated [(3)H]AA release and translocation of cytosolic phospholipase A(2) (cPLA(2)) from the cytosolic fraction to the membrane fraction.	Oxalates	0-7	cytosolic phospholipase A2	Oryctolagus cuniculus	87-93
15229103-11	2004	These findings suggest that oxalate inhibits renal PTC proliferation via oxidative stress, p38 MAPK/JNK, and cPLA(2) signaling pathways.	Oxalates	28-35	cytosolic phospholipase A2	Oryctolagus cuniculus	109-115