PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24909845-6	2015	Poly(dA:dT) and poly(I:C) stimulation increased SPATA18 level in primary keratinocytes, indicating the importance of mitochondria quality control under innate immune induced oxidative stress.	Poly I-C	16-24	spermatogenesis associated 18	Homo sapiens	48-55
24627031-0	2015	Tumor necrosis factor-alpha synergistically enhances polyinosinic-polycytidylic acid-induced toll-like receptor 3 signaling in cultured normal human mesangial cells: possible involvement in the pathogenesis of lupus nephritis.	Poly I-C	53-84	tumor necrosis factor	Homo sapiens	0-27
24627031-0	2015	Tumor necrosis factor-alpha synergistically enhances polyinosinic-polycytidylic acid-induced toll-like receptor 3 signaling in cultured normal human mesangial cells: possible involvement in the pathogenesis of lupus nephritis.	Poly I-C	53-84	toll like receptor 3	Homo sapiens	93-113
24708269-9	2015	Poly I:C, flagellin and TLR-9 agonist CpG ODN, as well as TNF-alpha, IFN-gamma, IL-6, IL-17A and TGF-beta, significantly increased OPN mRNA expression in cultured PECs and NECs (P < 0.05).	Poly I-C	0-8	secreted phosphoprotein 1	Homo sapiens	131-134
25444175-3	2015	We previously demonstrated that the activation of TLR3 by the synthetic double-stranded RNA analogue poly I:C induces apoptosis of androgen-sensitive prostate cancer (PCa) LNCaP cells and, much less efficiently, of the more aggressive PC3 cell line.	Poly I-C	101-109	toll like receptor 3	Homo sapiens	50-54
25444175-9	2015	Notably, we show the presence of TLR3 and IRF-3 in both human normal and PCa clinical samples, potentially envisaging poly I:C-based therapy for PCa.	Poly I-C	118-126	toll like receptor 3	Homo sapiens	33-37
25444175-9	2015	Notably, we show the presence of TLR3 and IRF-3 in both human normal and PCa clinical samples, potentially envisaging poly I:C-based therapy for PCa.	Poly I-C	118-126	interferon regulatory factor 3	Homo sapiens	42-47
25332128-10	2015	CD8alpha mRNA in domestic ducklings was initially up-regulated, and then down-regulated, in the thymus, spleen, and liver after treatment with duck hepatitis virus type I (DHV-1) or the immunostimulant polyriboinosinic polyribocytidylic acid (poly I:C).	Poly I-C	202-241	T-cell surface glycoprotein CD8 alpha chain	Anas platyrhynchos	0-8
25059418-7	2015	Treatment with poly(I:C) specifically up-regulated surface expression of co-stimulatory molecules and increased release of IL-12p70 in MoLC and co-stimulation with TNF-alpha and IL-1beta further elevated Th1 and Th17 cytokine production.	Poly I-C	15-23	interleukin 1 beta	Homo sapiens	178-186
25100047-5	2015	PolyI:C, a double-stranded RNA TLR3 agonist, increased APOL1 expression by upregulating interferons directly or through an interferon-independent, IFN-regulatory factor 3 (IRF3)-dependent pathway.	Poly I-C	0-7	toll like receptor 3	Homo sapiens	31-35
25100047-5	2015	PolyI:C, a double-stranded RNA TLR3 agonist, increased APOL1 expression by upregulating interferons directly or through an interferon-independent, IFN-regulatory factor 3 (IRF3)-dependent pathway.	Poly I-C	0-7	apolipoprotein L1	Homo sapiens	55-60
25100047-5	2015	PolyI:C, a double-stranded RNA TLR3 agonist, increased APOL1 expression by upregulating interferons directly or through an interferon-independent, IFN-regulatory factor 3 (IRF3)-dependent pathway.	Poly I-C	0-7	interferon regulatory factor 3	Homo sapiens	147-170
25100047-5	2015	PolyI:C, a double-stranded RNA TLR3 agonist, increased APOL1 expression by upregulating interferons directly or through an interferon-independent, IFN-regulatory factor 3 (IRF3)-dependent pathway.	Poly I-C	0-7	interferon regulatory factor 3	Homo sapiens	172-176
25059418-7	2015	Treatment with poly(I:C) specifically up-regulated surface expression of co-stimulatory molecules and increased release of IL-12p70 in MoLC and co-stimulation with TNF-alpha and IL-1beta further elevated Th1 and Th17 cytokine production.	Poly I-C	15-23	tumor necrosis factor	Homo sapiens	164-173
25545218-4	2015	In vitro-generated LCs expressed TLR1-10 and robustly produced IL-6 and TNF-alpha in response to PolyI:C, but pre-exposure to L3s did not alter inflammatory cytokine production or TLR expression.	Poly I-C	97-104	interleukin 6	Homo sapiens	63-67
25545218-4	2015	In vitro-generated LCs expressed TLR1-10 and robustly produced IL-6 and TNF-alpha in response to PolyI:C, but pre-exposure to L3s did not alter inflammatory cytokine production or TLR expression.	Poly I-C	97-104	tumor necrosis factor	Homo sapiens	72-81
25545218-7	2015	While PolyI:C potently induced CCL22 production in LC, CD1c+ DC, and CD141+ DC, and IL-10 production in LC, L3s did not modulate the numbers of or cytokine production by any skin DC subset.	Poly I-C	6-13	C-C motif chemokine ligand 22	Homo sapiens	31-36
25595258-1	2015	Poly I:C injection induced a febrile response which was reduced by intracerebroventricular administration of the antibodies against TNF-alpha, IL-6, or IFN-gamma, or by IL-1 or mu receptor antagonists.	Poly I-C	0-8	tumor necrosis factor	Rattus norvegicus	132-141
25595258-1	2015	Poly I:C injection induced a febrile response which was reduced by intracerebroventricular administration of the antibodies against TNF-alpha, IL-6, or IFN-gamma, or by IL-1 or mu receptor antagonists.	Poly I-C	0-8	interleukin 6	Rattus norvegicus	143-147
25595258-1	2015	Poly I:C injection induced a febrile response which was reduced by intracerebroventricular administration of the antibodies against TNF-alpha, IL-6, or IFN-gamma, or by IL-1 or mu receptor antagonists.	Poly I-C	0-8	interferon gamma	Rattus norvegicus	152-161
24906486-5	2015	RESULTS: Poly I:C caused a significant increase in systolic blood pressure in pregnant (P-PIC) mice compared with vehicle-treated pregnant (P) mice.	Poly I-C	9-17	peptidylprolyl isomerase C	Mus musculus	88-93
25387996-2	2015	In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated with the TLR3 ligand poly(inosinic-polycytidylic acid) (poly(I:C)) in cationic liposomes consisting of DOTAP and DOPC.	Poly I-C	126-159	toll-like receptor 3	Mus musculus	114-118
25055998-6	2015	We found that polyinosinic-polycytidylic acid (poly-IC)-induced TSLP expression was suppressed by treatment with licochalcone A in a dose- and time-dependent manner.	Poly I-C	14-45	thymic stromal lymphopoietin	Homo sapiens	64-68
25997337-2	2015	Viperin expression can be largely upregulated by viruses, interferons, and oligonucleotides such as poly I:C and lipopolysaccharides.	Poly I-C	100-108	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7
25469248-1	2015	Retinoic acid-inducible gene-I (RIG-I)-like receptors [RLRs; RIG-I and melanoma differentiation-associated gene 5 (MDA5)] sense virus-derived RNA or a synthetic analog of double-stranded RNA polyinosinic-polycytidylic acid [poly(I:C)] and are responsible for host defense against viruses.	Poly I-C	191-222	DExD/H-box helicase 58	Homo sapiens	0-30
25469248-1	2015	Retinoic acid-inducible gene-I (RIG-I)-like receptors [RLRs; RIG-I and melanoma differentiation-associated gene 5 (MDA5)] sense virus-derived RNA or a synthetic analog of double-stranded RNA polyinosinic-polycytidylic acid [poly(I:C)] and are responsible for host defense against viruses.	Poly I-C	191-222	DExD/H-box helicase 58	Homo sapiens	32-37
25469248-1	2015	Retinoic acid-inducible gene-I (RIG-I)-like receptors [RLRs; RIG-I and melanoma differentiation-associated gene 5 (MDA5)] sense virus-derived RNA or a synthetic analog of double-stranded RNA polyinosinic-polycytidylic acid [poly(I:C)] and are responsible for host defense against viruses.	Poly I-C	191-222	DExD/H-box helicase 58	Homo sapiens	61-66
25469248-1	2015	Retinoic acid-inducible gene-I (RIG-I)-like receptors [RLRs; RIG-I and melanoma differentiation-associated gene 5 (MDA5)] sense virus-derived RNA or a synthetic analog of double-stranded RNA polyinosinic-polycytidylic acid [poly(I:C)] and are responsible for host defense against viruses.	Poly I-C	191-222	interferon induced with helicase C domain 1	Homo sapiens	71-113
25469248-1	2015	Retinoic acid-inducible gene-I (RIG-I)-like receptors [RLRs; RIG-I and melanoma differentiation-associated gene 5 (MDA5)] sense virus-derived RNA or a synthetic analog of double-stranded RNA polyinosinic-polycytidylic acid [poly(I:C)] and are responsible for host defense against viruses.	Poly I-C	191-222	interferon induced with helicase C domain 1	Homo sapiens	115-119
26039883-0	2015	Addition of CpG ODN and Poly (I:C) to a standard maturation cocktail generates monocyte-derived dendritic cells and induces a potent Th1 polarization with migratory capacity.	Poly I-C	24-34	negative elongation factor complex member C/D	Homo sapiens	133-136
25257859-0	2015	PolyI:C and mouse survivin artificially embedding human 2B peptide induce a CD4+ T cell response to autologous survivin in HLA-A*2402 transgenic mice.	Poly I-C	0-7	CD4 molecule	Homo sapiens	76-79
25257859-0	2015	PolyI:C and mouse survivin artificially embedding human 2B peptide induce a CD4+ T cell response to autologous survivin in HLA-A*2402 transgenic mice.	Poly I-C	0-7	baculoviral IAP repeat-containing 5	Mus musculus	111-119
25257859-0	2015	PolyI:C and mouse survivin artificially embedding human 2B peptide induce a CD4+ T cell response to autologous survivin in HLA-A*2402 transgenic mice.	Poly I-C	0-7	major histocompatibility complex, class I, A	Homo sapiens	123-128
25257859-8	2015	However, the CD4(+) T cell response, as monitored by IFN-gamma, was significantly increased in mice given polyI:C+MmSVN2B.	Poly I-C	106-113	CD4 antigen	Mus musculus	13-16
25257859-8	2015	However, the CD4(+) T cell response, as monitored by IFN-gamma, was significantly increased in mice given polyI:C+MmSVN2B.	Poly I-C	106-113	interferon gamma	Mus musculus	53-62
25257859-9	2015	The Th1 response and antibody production were enhanced in the mice with polyI:C.	Poly I-C	72-79	negative elongation factor complex member C/D, Th1l	Mus musculus	4-7
25257859-11	2015	These results suggest that activated, self-reactive CD4(+) helper T cells proliferate in MmSVN2B+polyI:C immunization and contribute to Th1 polarization followed by antibody production, but hardly participate in CTL induction.	Poly I-C	97-104	CD4 antigen	Mus musculus	52-55
25055998-6	2015	We found that polyinosinic-polycytidylic acid (poly-IC)-induced TSLP expression was suppressed by treatment with licochalcone A in a dose- and time-dependent manner.	Poly I-C	47-54	thymic stromal lymphopoietin	Homo sapiens	64-68
25055998-7	2015	We also found that poly-IC-induced mRNA expression of other proinflammatory mediators such as MCP-1, RANTES, and IL-8 was suppressed by licochalcone A.	Poly I-C	19-26	C-C motif chemokine ligand 2	Homo sapiens	94-99
25055998-7	2015	We also found that poly-IC-induced mRNA expression of other proinflammatory mediators such as MCP-1, RANTES, and IL-8 was suppressed by licochalcone A.	Poly I-C	19-26	C-C motif chemokine ligand 5	Homo sapiens	101-107
25055998-7	2015	We also found that poly-IC-induced mRNA expression of other proinflammatory mediators such as MCP-1, RANTES, and IL-8 was suppressed by licochalcone A.	Poly I-C	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
25577792-4	2015	It was shown that CD8alpha mRNA levels were significantly up-regulated by in vitro treatment of MNCs with phytohemagglutinin (PHA), concanavalin A (ConA), and polyinosinic-polycytidylic acid (poly I:C) in a dose-dependent way, but lipopolysaccharides (LPSs) did not have this same effect.	Poly I-C	159-190	CD8a molecule	Homo sapiens	18-26
25422508-6	2015	However, in response to injections with LPS (a bacterial mimic) or polyinosinic-polycytidylic acid (a viral mimic), M-TRAF3(-/-) mice exhibited an altered profile of cytokine production.	Poly I-C	67-98	TNF receptor-associated factor 3	Mus musculus	118-123
25577792-4	2015	It was shown that CD8alpha mRNA levels were significantly up-regulated by in vitro treatment of MNCs with phytohemagglutinin (PHA), concanavalin A (ConA), and polyinosinic-polycytidylic acid (poly I:C) in a dose-dependent way, but lipopolysaccharides (LPSs) did not have this same effect.	Poly I-C	192-200	CD8a molecule	Homo sapiens	18-26
25467889-5	2014	The expression of IL6 in the uterus and vagina was upregulated by poly I:C and CpG-ODN, and it was also upregulated by Pam3CSK4 in the uterus and by R848 in the vagina.	Poly I-C	66-74	interleukin 6	Gallus gallus	18-21
25218983-2	2014	We have recently demonstrated the role of interferon-induced transmembrane protein 3 (IFITM3) in long-lasting neuronal impairments in mice following neonatal immune challenge by injections of the double-stranded RNA analog polyriboinosinic polyribocytidylic acid.	Poly I-C	223-262	interferon induced transmembrane protein 3	Mus musculus	42-84
25218983-2	2014	We have recently demonstrated the role of interferon-induced transmembrane protein 3 (IFITM3) in long-lasting neuronal impairments in mice following neonatal immune challenge by injections of the double-stranded RNA analog polyriboinosinic polyribocytidylic acid.	Poly I-C	223-262	interferon induced transmembrane protein 3	Mus musculus	86-92
25608815-4	2015	The results showed that, most of the cytokines or receptors had obvious expression change compared with the control (without Poly I:C stimulation), especially the three cytokine genes IL6, IL8 and IL10, whose average expression change times were 20.71, 10.87 and 5.18, respectively.	Poly I-C	125-133	interleukin 6	Homo sapiens	184-187
25608815-4	2015	The results showed that, most of the cytokines or receptors had obvious expression change compared with the control (without Poly I:C stimulation), especially the three cytokine genes IL6, IL8 and IL10, whose average expression change times were 20.71, 10.87 and 5.18, respectively.	Poly I-C	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	189-192
25608815-4	2015	The results showed that, most of the cytokines or receptors had obvious expression change compared with the control (without Poly I:C stimulation), especially the three cytokine genes IL6, IL8 and IL10, whose average expression change times were 20.71, 10.87 and 5.18, respectively.	Poly I-C	125-133	interleukin 10	Homo sapiens	197-201
25079212-4	2014	As an example we used ligands for TLR3 (Synthetic double stranded RNA [dsRNA], polyinosinic-polycytidylic acid [poly(I:C)] mimicking viral dsRNA), TLR4 (lipopolysaccharide [LPS], found in the outer membrane of Gram-negative bacteria) and TLR9 (Synthetic oligodeoxynucleotide mimicking bacterial DNA [CpG-ODN]).	Poly I-C	79-110	toll like receptor 3	Homo sapiens	34-38
25453343-2	2014	Here we demonstrate that TLR3 signaling of monocyte-derived macrophages (MDM) from rhesus monkeys by poly I:C inhibited simian immunodeficiency virus (SIV) infection and replication.	Poly I-C	101-109	toll like receptor 3	Macaca mulatta	25-29
25224571-0	2014	Phosphorothioate modification of the TLR9 ligand CpG ODN inhibits poly(I:C)-induced apoptosis of hepatocellular carcinoma by entry blockade.	Poly I-C	66-75	toll like receptor 9	Homo sapiens	37-41
25315747-6	2014	Human platelets responded to poly I:C by increasing [Ca(2+)]i, the percentages of cells expressing TLR4 and CD62P, and by releasing CXCL4 and IL-1beta in comparison to unstimulated platelets.	Poly I-C	29-37	toll like receptor 4	Homo sapiens	99-103
25315747-6	2014	Human platelets responded to poly I:C by increasing [Ca(2+)]i, the percentages of cells expressing TLR4 and CD62P, and by releasing CXCL4 and IL-1beta in comparison to unstimulated platelets.	Poly I-C	29-37	selectin P	Homo sapiens	108-113
25315747-6	2014	Human platelets responded to poly I:C by increasing [Ca(2+)]i, the percentages of cells expressing TLR4 and CD62P, and by releasing CXCL4 and IL-1beta in comparison to unstimulated platelets.	Poly I-C	29-37	platelet factor 4	Homo sapiens	132-137
25315747-6	2014	Human platelets responded to poly I:C by increasing [Ca(2+)]i, the percentages of cells expressing TLR4 and CD62P, and by releasing CXCL4 and IL-1beta in comparison to unstimulated platelets.	Poly I-C	29-37	interleukin 1 beta	Homo sapiens	142-150
24930695-13	2014	Microglia cells respond to Poly I:C stimulation in a concentration-dependent manner with the induction of IL-1ss, IL-6, TNFalpha, Cox2, iNOS and, to a lesser degree, IL-10.	Poly I-C	27-35	interleukin 6	Sus scrofa	114-118
24930695-13	2014	Microglia cells respond to Poly I:C stimulation in a concentration-dependent manner with the induction of IL-1ss, IL-6, TNFalpha, Cox2, iNOS and, to a lesser degree, IL-10.	Poly I-C	27-35	tumor necrosis factor	Sus scrofa	120-128
24930695-13	2014	Microglia cells respond to Poly I:C stimulation in a concentration-dependent manner with the induction of IL-1ss, IL-6, TNFalpha, Cox2, iNOS and, to a lesser degree, IL-10.	Poly I-C	27-35	cytochrome c oxidase subunit II	Sus scrofa	130-134
24930695-13	2014	Microglia cells respond to Poly I:C stimulation in a concentration-dependent manner with the induction of IL-1ss, IL-6, TNFalpha, Cox2, iNOS and, to a lesser degree, IL-10.	Poly I-C	27-35	nitric oxide synthase 2	Sus scrofa	136-140
24930695-13	2014	Microglia cells respond to Poly I:C stimulation in a concentration-dependent manner with the induction of IL-1ss, IL-6, TNFalpha, Cox2, iNOS and, to a lesser degree, IL-10.	Poly I-C	27-35	IL10	Sus scrofa	166-171
25346475-12	2014	The efficacy of DEC-205 mAb targeting strategy can be boosted by addition of poly I:C underlining the potential of this combination for immunotherapeutical interventions.	Poly I-C	77-85	lymphocyte antigen 75	Homo sapiens	16-23
25079212-4	2014	As an example we used ligands for TLR3 (Synthetic double stranded RNA [dsRNA], polyinosinic-polycytidylic acid [poly(I:C)] mimicking viral dsRNA), TLR4 (lipopolysaccharide [LPS], found in the outer membrane of Gram-negative bacteria) and TLR9 (Synthetic oligodeoxynucleotide mimicking bacterial DNA [CpG-ODN]).	Poly I-C	112-121	toll like receptor 3	Homo sapiens	34-38
25264520-10	2014	Human AEC pre-treated with IL-4 and IL-13, then stimulated with poly I:C, similarly exhibited significantly higher expression of IL8, CXCL9, CXCL10, CXCL11 and CCL5 genes.	Poly I-C	64-72	interleukin 4	Homo sapiens	27-31
25287058-5	2014	Using RNase L-deficient, rat insulin promoter-B7.1 transgenic mice, which are more vulnerable to harmful environmental factors such as viral infection, we demonstrated that deficiency of RNase L in mice resulted in a significant delay of diabetes onset induced by polyinosinic:polycytidylic acid (poly I:C), a type of synthetic dsRNA, and streptozotocin, a drug which can artificially induce type 1-like diabetes in experimental animals.	Poly I-C	297-305	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	Mus musculus	187-194
25264520-10	2014	Human AEC pre-treated with IL-4 and IL-13, then stimulated with poly I:C, similarly exhibited significantly higher expression of IL8, CXCL9, CXCL10, CXCL11 and CCL5 genes.	Poly I-C	64-72	interleukin 13	Homo sapiens	36-41
25264520-10	2014	Human AEC pre-treated with IL-4 and IL-13, then stimulated with poly I:C, similarly exhibited significantly higher expression of IL8, CXCL9, CXCL10, CXCL11 and CCL5 genes.	Poly I-C	64-72	C-X-C motif chemokine ligand 8	Homo sapiens	129-132
25264520-10	2014	Human AEC pre-treated with IL-4 and IL-13, then stimulated with poly I:C, similarly exhibited significantly higher expression of IL8, CXCL9, CXCL10, CXCL11 and CCL5 genes.	Poly I-C	64-72	C-X-C motif chemokine ligand 9	Homo sapiens	134-139
25264520-10	2014	Human AEC pre-treated with IL-4 and IL-13, then stimulated with poly I:C, similarly exhibited significantly higher expression of IL8, CXCL9, CXCL10, CXCL11 and CCL5 genes.	Poly I-C	64-72	C-X-C motif chemokine ligand 10	Homo sapiens	141-147
25264520-10	2014	Human AEC pre-treated with IL-4 and IL-13, then stimulated with poly I:C, similarly exhibited significantly higher expression of IL8, CXCL9, CXCL10, CXCL11 and CCL5 genes.	Poly I-C	64-72	C-X-C motif chemokine ligand 11	Homo sapiens	149-155
25264520-10	2014	Human AEC pre-treated with IL-4 and IL-13, then stimulated with poly I:C, similarly exhibited significantly higher expression of IL8, CXCL9, CXCL10, CXCL11 and CCL5 genes.	Poly I-C	64-72	C-C motif chemokine ligand 5	Homo sapiens	160-164
25417649-4	2014	Consistent with these functional studies, ligand activation of RXR inhibits the expression of antiviral genes including type I interferon (IFN) and Rxra-/- macrophages produce more IFNbeta than WT macrophages in response to polyI:C stimulation.	Poly I-C	224-231	retinoid X receptor alpha	Homo sapiens	63-66
25417649-4	2014	Consistent with these functional studies, ligand activation of RXR inhibits the expression of antiviral genes including type I interferon (IFN) and Rxra-/- macrophages produce more IFNbeta than WT macrophages in response to polyI:C stimulation.	Poly I-C	224-231	interferon alpha 1	Homo sapiens	120-143
25419735-5	2014	Poly (I:C) induces the expression of TLR3 in vivo and hereby allows for amplification of all of the aforementioned responses upon viral infection.	Poly I-C	0-9	toll like receptor 3	Homo sapiens	37-41
25320282-0	2014	INAM plays a critical role in IFN-gamma production by NK cells interacting with polyinosinic-polycytidylic acid-stimulated accessory cells.	Poly I-C	80-111	interferon gamma	Mus musculus	30-39
25014275-4	2014	Interestingly, the TLR3 agonist polyinosinic:polycytidylic acid (poly(I:C)) mediated phosphorylation of NF-kappaB and extracellular stress-related kinase 1/2 (ERK1/2), which significantly decreased following PGE2 treatment.	Poly I-C	65-74	toll like receptor 3	Homo sapiens	19-23
25014275-4	2014	Interestingly, the TLR3 agonist polyinosinic:polycytidylic acid (poly(I:C)) mediated phosphorylation of NF-kappaB and extracellular stress-related kinase 1/2 (ERK1/2), which significantly decreased following PGE2 treatment.	Poly I-C	65-74	mitogen-activated protein kinase 3	Homo sapiens	159-165
25320282-1	2014	Polyinosinic-polycytidylic acid strongly promotes the antitumor activity of NK cells via TLR3/Toll/IL-1R domain-containing adaptor molecule 1 and melanoma differentiation-associated protein-5/mitochondrial antiviral signaling protein pathways.	Poly I-C	0-31	toll-like receptor 3	Mus musculus	89-93
25320282-1	2014	Polyinosinic-polycytidylic acid strongly promotes the antitumor activity of NK cells via TLR3/Toll/IL-1R domain-containing adaptor molecule 1 and melanoma differentiation-associated protein-5/mitochondrial antiviral signaling protein pathways.	Poly I-C	0-31	interferon induced with helicase C domain 1	Mus musculus	99-191
25320282-1	2014	Polyinosinic-polycytidylic acid strongly promotes the antitumor activity of NK cells via TLR3/Toll/IL-1R domain-containing adaptor molecule 1 and melanoma differentiation-associated protein-5/mitochondrial antiviral signaling protein pathways.	Poly I-C	0-31	mitochondrial antiviral signaling protein	Mus musculus	192-233
25320283-0	2014	Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1.	Poly I-C	23-54	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	123-127
25219356-11	2014	Osteopontin mRNA and cleaved protein was up-regulated in Wfdc1-null cells treated with lipopolysaccharide or polyinosinic-polycytidylic acid coordinate with constitutively active matrix metallopeptidase-9 (MMP-9), a protease that cleaves osteopontin.	Poly I-C	109-140	secreted phosphoprotein 1	Mus musculus	0-11
24903157-10	2014	This inhibition of FC-99 was related to the poly(I:C)-evoked IRF3/IFN-alpha/JAK/STAT1 signalling pathway.	Poly I-C	44-53	interferon regulatory factor 3	Mus musculus	61-65
24903157-10	2014	This inhibition of FC-99 was related to the poly(I:C)-evoked IRF3/IFN-alpha/JAK/STAT1 signalling pathway.	Poly I-C	44-53	interferon alpha	Mus musculus	66-75
24903157-10	2014	This inhibition of FC-99 was related to the poly(I:C)-evoked IRF3/IFN-alpha/JAK/STAT1 signalling pathway.	Poly I-C	44-53	signal transducer and activator of transcription 1	Mus musculus	80-85
25219356-11	2014	Osteopontin mRNA and cleaved protein was up-regulated in Wfdc1-null cells treated with lipopolysaccharide or polyinosinic-polycytidylic acid coordinate with constitutively active matrix metallopeptidase-9 (MMP-9), a protease that cleaves osteopontin.	Poly I-C	109-140	WAP four-disulfide core domain 1	Mus musculus	57-62
25230295-6	2014	Moreover, these cells could be stimulated by poly I:C, showing significant up-regulation in the expression of the genes that regulate immune responses, such as ifn and mx-1.	Poly I-C	45-53	myxovirus resistance 1	Salmo salar	168-172
25461559-11	2014	Finally, Niram significantly inhibited the levels of TSLP in polyriboinosinic polyribocytidylic acid-stimulated human keratinocyte HaCaT cells.	Poly I-C	61-100	thymic stromal lymphopoietin	Homo sapiens	53-57
24981291-13	2014	The expression of p28 but not Ebi3 was induced by PAMPs and recombinant cytokines in head kidney cells, and in spleen by Poly I:C challenge in vivo.	Poly I-C	121-129	golgi SNAP receptor complex member 1	Homo sapiens	18-21
25059476-4	2014	TLR3 activation was induced by polyinosinic:polycytidylic acid (Poly I:C).	Poly I-C	31-62	toll like receptor 3	Homo sapiens	0-4
25059476-4	2014	TLR3 activation was induced by polyinosinic:polycytidylic acid (Poly I:C).	Poly I-C	64-72	toll like receptor 3	Homo sapiens	0-4
25264029-6	2014	The neurotoxic and protective effects of Poly (I:C) stimulation were absent in TLR3 knockout animals, which indicates that protection by Poly (I:C) is dependent on the TLR3 signaling pathway.	Poly I-C	41-51	toll-like receptor 3	Mus musculus	168-172
25264029-6	2014	The neurotoxic and protective effects of Poly (I:C) stimulation were absent in TLR3 knockout animals, which indicates that protection by Poly (I:C) is dependent on the TLR3 signaling pathway.	Poly I-C	137-147	toll-like receptor 3	Mus musculus	79-83
25264029-6	2014	The neurotoxic and protective effects of Poly (I:C) stimulation were absent in TLR3 knockout animals, which indicates that protection by Poly (I:C) is dependent on the TLR3 signaling pathway.	Poly I-C	137-147	toll-like receptor 3	Mus musculus	168-172
25360821-6	2014	Transfection of miR-30a-3p antisense in Poly(I:C)- and IFN-gamma-activated NFLS and NHDF upregulated BAFF secretion, confirming that this microRNA is a basal repressors of BAFF expression in cells from healthy donors.	Poly I-C	40-49	TNF superfamily member 13b	Homo sapiens	101-105
25360821-6	2014	Transfection of miR-30a-3p antisense in Poly(I:C)- and IFN-gamma-activated NFLS and NHDF upregulated BAFF secretion, confirming that this microRNA is a basal repressors of BAFF expression in cells from healthy donors.	Poly I-C	40-49	TNF superfamily member 13b	Homo sapiens	172-176
25343451-6	2014	We also found that diabetes progression in SR-A-/- NOD mice treated with low-dose polyinosinic-polycytidylic acid (poly(I:C)) was significantly accelerated compared with that in disease-resistant NOD mice treated with low-dose poly(I:C).	Poly I-C	82-113	macrophage scavenger receptor 1	Mus musculus	43-47
24179040-4	2014	We show that pre-treatment of macrophages with Berenil dramatically suppressed IL-6, IL-12 and TNF-alpha production following LPS, CpG and Poly I:C stimulation without altering the expression of TLRs.	Poly I-C	139-147	interleukin 6	Mus musculus	79-83
25225670-6	2014	Mechanistically, Mavs triggered membrane permeabilization and K(+) efflux independently of the inflammasome which were required for poly(I:C)-induced Nlrp3 activation.	Poly I-C	132-141	mitochondrial antiviral signaling protein	Homo sapiens	17-21
25225670-6	2014	Mechanistically, Mavs triggered membrane permeabilization and K(+) efflux independently of the inflammasome which were required for poly(I:C)-induced Nlrp3 activation.	Poly I-C	132-141	NLR family pyrin domain containing 3	Homo sapiens	150-155
25225670-7	2014	We conclude that poly (I:C) activates the inflammasome through an Mavs-dependent surveillance pathway that converges into a common K(+) lowering step in the cytosol that is essential for the induction of Nlrp3 activation.	Poly I-C	17-26	mitochondrial antiviral signaling protein	Homo sapiens	66-70
25225670-7	2014	We conclude that poly (I:C) activates the inflammasome through an Mavs-dependent surveillance pathway that converges into a common K(+) lowering step in the cytosol that is essential for the induction of Nlrp3 activation.	Poly I-C	17-26	NLR family pyrin domain containing 3	Homo sapiens	204-209
25023628-5	2014	Poly(I:C)-matured moDCs significantly augmented the expression of NKG2A, but not KIR, in an IL12p70-dependent manner.	Poly I-C	0-9	killer cell lectin like receptor C1	Homo sapiens	66-71
25023628-5	2014	Poly(I:C)-matured moDCs significantly augmented the expression of NKG2A, but not KIR, in an IL12p70-dependent manner.	Poly I-C	0-9	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	81-84
25117451-5	2014	Similarly, the presence of AM reduced the protein expression of MDA5, RIG-1, and TLR3 on poly I:C stimulated HLM.	Poly I-C	89-97	interferon induced with helicase C domain 1	Homo sapiens	64-68
25117451-5	2014	Similarly, the presence of AM reduced the protein expression of MDA5, RIG-1, and TLR3 on poly I:C stimulated HLM.	Poly I-C	89-97	phospholipase A and acyltransferase 4	Homo sapiens	70-75
25117451-5	2014	Similarly, the presence of AM reduced the protein expression of MDA5, RIG-1, and TLR3 on poly I:C stimulated HLM.	Poly I-C	89-97	toll like receptor 3	Homo sapiens	81-85
25117451-6	2014	Additionally, the presence of the AM significantly inhibited the NF-kappaB nuclear translocation when the HLM were poly I:C stimulated, and concomitantly, the AM was able to relocate cadherins affecting the myofibroblastic cellular morphology.	Poly I-C	115-123	nuclear factor kappa B subunit 1	Homo sapiens	65-74
25040499-15	2014	Furthermore, direct application of poly-I:C enhanced IL-1beta expression in primary microglia.	Poly I-C	35-43	interleukin 1 beta	Rattus norvegicus	53-61
25040499-16	2014	We therefore propose that poly-I:C-induced microglial activation, which may be at least partly caused by a direct action of poly-I:C, enhances IL-1beta expression.	Poly I-C	26-34	interleukin 1 beta	Rattus norvegicus	143-151
25040499-16	2014	We therefore propose that poly-I:C-induced microglial activation, which may be at least partly caused by a direct action of poly-I:C, enhances IL-1beta expression.	Poly I-C	124-132	interleukin 1 beta	Rattus norvegicus	143-151
25145495-5	2014	The effect of TLR3 (poly I:C) and TLR9 (CpG) co-stimulation of THP-1-derived monocytes using purified TLR ligands showed that 24 h after exposure poly I:C and CpG ligands in combination, hepcidin expression was significantly increased (10-fold) when compared to the untreated control.	Poly I-C	20-28	toll like receptor 3	Homo sapiens	14-18
25145495-5	2014	The effect of TLR3 (poly I:C) and TLR9 (CpG) co-stimulation of THP-1-derived monocytes using purified TLR ligands showed that 24 h after exposure poly I:C and CpG ligands in combination, hepcidin expression was significantly increased (10-fold) when compared to the untreated control.	Poly I-C	20-28	GLI family zinc finger 2	Homo sapiens	63-68
25145495-5	2014	The effect of TLR3 (poly I:C) and TLR9 (CpG) co-stimulation of THP-1-derived monocytes using purified TLR ligands showed that 24 h after exposure poly I:C and CpG ligands in combination, hepcidin expression was significantly increased (10-fold) when compared to the untreated control.	Poly I-C	146-154	toll like receptor 3	Homo sapiens	14-18
25145495-5	2014	The effect of TLR3 (poly I:C) and TLR9 (CpG) co-stimulation of THP-1-derived monocytes using purified TLR ligands showed that 24 h after exposure poly I:C and CpG ligands in combination, hepcidin expression was significantly increased (10-fold) when compared to the untreated control.	Poly I-C	146-154	toll like receptor 9	Homo sapiens	34-38
25145495-5	2014	The effect of TLR3 (poly I:C) and TLR9 (CpG) co-stimulation of THP-1-derived monocytes using purified TLR ligands showed that 24 h after exposure poly I:C and CpG ligands in combination, hepcidin expression was significantly increased (10-fold) when compared to the untreated control.	Poly I-C	146-154	GLI family zinc finger 2	Homo sapiens	63-68
25145495-5	2014	The effect of TLR3 (poly I:C) and TLR9 (CpG) co-stimulation of THP-1-derived monocytes using purified TLR ligands showed that 24 h after exposure poly I:C and CpG ligands in combination, hepcidin expression was significantly increased (10-fold) when compared to the untreated control.	Poly I-C	146-154	hepcidin antimicrobial peptide	Homo sapiens	187-195
24179040-4	2014	We show that pre-treatment of macrophages with Berenil dramatically suppressed IL-6, IL-12 and TNF-alpha production following LPS, CpG and Poly I:C stimulation without altering the expression of TLRs.	Poly I-C	139-147	tumor necrosis factor	Mus musculus	95-104
24870617-10	2014	In comparison with the heterologous prime-boost regimen, the homologous prime-boost vaccinations with DNA co-administrated with polyinosinic-polycytidylic acid (poly I:C) generated the highest specific IgG and IgG2a titers as well as the greatest IFNgamma production.	Poly I-C	128-159	interferon gamma	Homo sapiens	247-255
25478290-4	2014	In the present study, we tested the hypothesis that MUC18 exerts a pro-inflammatory function during stimulation with a viral mimic polyI:C or human rhinovirus infection.	Poly I-C	131-138	melanoma cell adhesion molecule	Homo sapiens	52-57
25478290-7	2014	RESULTS: We found that MUC18 over-expression promoted IL-8 production, while it inhibited IFN-beta expression following polyI:C stimulation or HRV infection.	Poly I-C	120-127	melanoma cell adhesion molecule	Homo sapiens	23-28
25478290-7	2014	RESULTS: We found that MUC18 over-expression promoted IL-8 production, while it inhibited IFN-beta expression following polyI:C stimulation or HRV infection.	Poly I-C	120-127	interferon beta 1	Homo sapiens	90-98
25478290-9	2014	Reduction of MUC18 serine phosphorylation by inhibiting ERK activity was associated with less production of IL-8 following polyI:C stimulation.	Poly I-C	123-130	melanoma cell adhesion molecule	Homo sapiens	13-18
25478290-9	2014	Reduction of MUC18 serine phosphorylation by inhibiting ERK activity was associated with less production of IL-8 following polyI:C stimulation.	Poly I-C	123-130	mitogen-activated protein kinase 1	Homo sapiens	56-59
25478290-9	2014	Reduction of MUC18 serine phosphorylation by inhibiting ERK activity was associated with less production of IL-8 following polyI:C stimulation.	Poly I-C	123-130	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
25100852-6	2014	When overexpressed in HEK293T cells, the X domain (or macro domain) inhibited poly(I C)-induced phosphorylation of interferon regulatory factor 3 (IRF-3), which is the key transcription factor for IFN induction.	Poly I-C	78-87	interferon regulatory factor 3	Homo sapiens	147-152
25100852-6	2014	When overexpressed in HEK293T cells, the X domain (or macro domain) inhibited poly(I C)-induced phosphorylation of interferon regulatory factor 3 (IRF-3), which is the key transcription factor for IFN induction.	Poly I-C	78-87	interferon alpha 1	Homo sapiens	197-200
25100852-4	2014	In this study, we found that HEV replication in hepatoma cells inhibited poly(I C)-induced beta interferon (IFN-beta) expression and that the HEV open reading frame 1 (ORF1) product was responsible for this inhibition.	Poly I-C	73-82	interferon alpha 1	Homo sapiens	108-111
25100852-6	2014	When overexpressed in HEK293T cells, the X domain (or macro domain) inhibited poly(I C)-induced phosphorylation of interferon regulatory factor 3 (IRF-3), which is the key transcription factor for IFN induction.	Poly I-C	78-87	interferon regulatory factor 3	Homo sapiens	115-145
25271853-8	2014	Addition of IL-6 to the same cells after stimulation with poly(I-C), CpG, Pam2CSK4, and MDP induced a significant increase in IL-1beta and CXCL8, but not TNF-alpha production compared with TLR ligands alone.	Poly I-C	58-67	interleukin 6	Homo sapiens	12-16
25271853-8	2014	Addition of IL-6 to the same cells after stimulation with poly(I-C), CpG, Pam2CSK4, and MDP induced a significant increase in IL-1beta and CXCL8, but not TNF-alpha production compared with TLR ligands alone.	Poly I-C	58-67	interleukin 1 beta	Homo sapiens	126-134
24601852-7	2014	The uptake of poly (I:C) conjugated with fluorescein isothiocyanate (FITC) into the keratinocytes was observed in the presence of LL-37.	Poly I-C	14-23	cathelicidin antimicrobial peptide	Homo sapiens	130-135
25227113-0	2014	Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-beta-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system.	Poly I-C	16-25	interferon beta 1	Homo sapiens	85-100
25227113-7	2014	Furthermore, poly(I:C) transfection increased the levels of phosphorylated p53, NOXA, and tBid.	Poly I-C	13-21	tumor protein p53	Homo sapiens	75-78
25227113-7	2014	Furthermore, poly(I:C) transfection increased the levels of phosphorylated p53, NOXA, and tBid.	Poly I-C	13-21	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	80-84
25227113-8	2014	Immunoblots and assays with a panel of caspase inhibitors revealed that poly(I:C) transfection-induced apoptosis was dependent on caspase-8 and -9, as well as caspase-2.	Poly I-C	72-80	caspase 2	Homo sapiens	39-46
25227113-8	2014	Immunoblots and assays with a panel of caspase inhibitors revealed that poly(I:C) transfection-induced apoptosis was dependent on caspase-8 and -9, as well as caspase-2.	Poly I-C	72-80	caspase 8	Homo sapiens	130-146
25227113-8	2014	Immunoblots and assays with a panel of caspase inhibitors revealed that poly(I:C) transfection-induced apoptosis was dependent on caspase-8 and -9, as well as caspase-2.	Poly I-C	72-80	caspase 2	Homo sapiens	159-168
25227113-12	2014	CONCLUSIONS: These results suggest that poly(I:C) transfection induced two types of effects against RCC cells such as apoptosis, as a result of ROS-mediated DNA damage, and IFN-beta-mediated growth arrest, both of which were exerted via innate adjuvant receptors and the 2-5A system.	Poly I-C	40-48	interferon beta 1	Homo sapiens	173-181
24693944-0	2014	MUC1 regulates epithelial inflammation and apoptosis by PolyI:C through inhibition of Toll/IL-1 receptor-domain-containing adapter-inducing IFN-beta (TRIF) recruitment to Toll-like receptor 3.	Poly I-C	56-63	mucin 1, cell surface associated	Homo sapiens	0-4
24693944-0	2014	MUC1 regulates epithelial inflammation and apoptosis by PolyI:C through inhibition of Toll/IL-1 receptor-domain-containing adapter-inducing IFN-beta (TRIF) recruitment to Toll-like receptor 3.	Poly I-C	56-63	toll like receptor 4	Homo sapiens	86-90
24693944-0	2014	MUC1 regulates epithelial inflammation and apoptosis by PolyI:C through inhibition of Toll/IL-1 receptor-domain-containing adapter-inducing IFN-beta (TRIF) recruitment to Toll-like receptor 3.	Poly I-C	56-63	TIR domain containing adaptor molecule 1	Homo sapiens	150-154
24693944-4	2014	Compared with MUC1/Muc1-expressing controls, cells deficient in MUC1/Muc1 were more prone to poly(I:C)-induced apoptosis; had increased poly(I:C)-driven activation of caspase-3, caspase-8, IFN regulatory factor-3, and NF-kappaB; and displayed heightened IFN-beta gene expression.	Poly I-C	93-102	mucin 1, cell surface associated	Homo sapiens	64-68
24693944-4	2014	Compared with MUC1/Muc1-expressing controls, cells deficient in MUC1/Muc1 were more prone to poly(I:C)-induced apoptosis; had increased poly(I:C)-driven activation of caspase-3, caspase-8, IFN regulatory factor-3, and NF-kappaB; and displayed heightened IFN-beta gene expression.	Poly I-C	93-102	mucin 1, cell surface associated	Homo sapiens	69-73
24693944-6	2014	Reciprocal coimmunoprecipitation experiments established constitutive TLR3/MUC1-CT (cytoplasmic tail) protein interaction in human embryonic kidney (HEK)293T cells overexpressing the two proteins and in lung epithelial cells expressing the endogenous proteins, the latter of which was confirmed by immunofluorescence colocalization of TLR3 with MUC1-CT. Coimmunoprecipitation studies also revealed that MUC1 overexpression by HEK293T cells reduced poly(I:C)-induced TLR3/TRIF protein interaction.	Poly I-C	448-457	toll like receptor 3	Homo sapiens	70-74
24693944-6	2014	Reciprocal coimmunoprecipitation experiments established constitutive TLR3/MUC1-CT (cytoplasmic tail) protein interaction in human embryonic kidney (HEK)293T cells overexpressing the two proteins and in lung epithelial cells expressing the endogenous proteins, the latter of which was confirmed by immunofluorescence colocalization of TLR3 with MUC1-CT. Coimmunoprecipitation studies also revealed that MUC1 overexpression by HEK293T cells reduced poly(I:C)-induced TLR3/TRIF protein interaction.	Poly I-C	448-457	mucin 1, cell surface associated	Homo sapiens	75-79
24601852-9	2014	RESULTS: LL-37 and poly (I:C) synergistically induced the expression of IFN-beta in NHEKs.	Poly I-C	19-28	interferon beta 1	Homo sapiens	72-80
24601852-11	2014	LL-37 enhanced the uptake of FITC-conjugated poly (I:C) into cells.	Poly I-C	45-54	cathelicidin antimicrobial peptide	Homo sapiens	0-5
25108021-6	2014	In this study, we show that that ADAM17 deficiency results in spleen and lymph node enlargement, as well as increased levels of Ag-specific class-switched Ig production following immunization with OVA together with anti-CD40 mAbs and polyinosinic-polycytidylic acid.	Poly I-C	234-265	a disintegrin and metallopeptidase domain 17	Mus musculus	33-39
25180573-8	2014	In the hypothalamus, prenatal exposure to PolyI:C caused significant global DNA hypomethylation (t=2.44, P=0.019, PolyI:C mean 69.67%, saline mean 70.19%), especially in females, and significant hypomethylation of the promoter region of Mecp2, (t=3.32, P=0.002; PolyI:C mean 26.57%, saline mean 34.63%).	Poly I-C	42-49	methyl CpG binding protein 2	Mus musculus	237-242
24456140-5	2014	In the present study, we report that the capsid protein also blocks IRF3-dependent apoptosis induced by the double-strand RNA mimic polyinosinic-polycytidylic acid.	Poly I-C	132-163	interferon regulatory factor 3	Homo sapiens	68-72
24995967-8	2014	Moreover, Ly6C(high) NK cells also revert to Ly6C(low) NK cells in vivo upon injection of the IL-15 inducers polyI:C and CpG.	Poly I-C	109-116	lymphocyte antigen 6 complex, locus C1	Mus musculus	45-49
24995967-8	2014	Moreover, Ly6C(high) NK cells also revert to Ly6C(low) NK cells in vivo upon injection of the IL-15 inducers polyI:C and CpG.	Poly I-C	109-116	interleukin 15	Mus musculus	94-99
25008936-4	2014	Subsequently, we showed that the inhibition of poly(I C)-induced IFN-beta production by PRRSV was dependent on the blocking of NF-kappaB signaling pathways.	Poly I-C	47-56	interferon beta 1	Homo sapiens	65-73
25008936-14	2014	We found that nsp4 interfered with the NF-kappaB signaling pathway through the cleavage of NEMO (a key regulator of NF-kappaB signaling) at the E349-S350 site, leading to the downregulation of IFN-beta production induced by poly(I C).	Poly I-C	224-232	serine protease 57	Homo sapiens	14-18
25008936-14	2014	We found that nsp4 interfered with the NF-kappaB signaling pathway through the cleavage of NEMO (a key regulator of NF-kappaB signaling) at the E349-S350 site, leading to the downregulation of IFN-beta production induced by poly(I C).	Poly I-C	224-232	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	91-95
25008936-14	2014	We found that nsp4 interfered with the NF-kappaB signaling pathway through the cleavage of NEMO (a key regulator of NF-kappaB signaling) at the E349-S350 site, leading to the downregulation of IFN-beta production induced by poly(I C).	Poly I-C	224-232	interferon beta 1	Homo sapiens	193-201
25158758-12	2014	Similarly, recombinant galectin-9 enhanced poly(I:C)-induced microglial TNF and IL-6 production.	Poly I-C	43-52	lectin, galactose binding, soluble 9	Mus musculus	23-33
25158758-12	2014	Similarly, recombinant galectin-9 enhanced poly(I:C)-induced microglial TNF and IL-6 production.	Poly I-C	43-52	tumor necrosis factor	Mus musculus	72-75
25158758-12	2014	Similarly, recombinant galectin-9 enhanced poly(I:C)-induced microglial TNF and IL-6 production.	Poly I-C	43-52	interleukin 6	Mus musculus	80-84
25049377-4	2014	Our results indicate that type I IFN (IFN-I) signaling is a predominant mechanism of necroptosis, because macrophages deficient in IFN-alpha receptor type I (IFNAR1) are highly resistant to necroptosis after stimulation with LPS, polyinosinic-polycytidylic acid, TNF-alpha, or IFN-beta in the presence of caspase inhibitors.	Poly I-C	230-261	interferon alpha and beta receptor subunit 1	Homo sapiens	158-164
24995967-8	2014	Moreover, Ly6C(high) NK cells also revert to Ly6C(low) NK cells in vivo upon injection of the IL-15 inducers polyI:C and CpG.	Poly I-C	109-116	lymphocyte antigen 6 complex, locus C1	Mus musculus	10-14
25200153-3	2014	Twenty-four hours later, real-time quantitative PCR was applied to detect the dynamic change of IFN-beta and Mx1 mRNA expressions under the stimulation of polyinosinic polycytidylic acid (PolyI:C).	Poly I-C	155-186	interferon omega 1	Gallus gallus	96-104
25200153-3	2014	Twenty-four hours later, real-time quantitative PCR was applied to detect the dynamic change of IFN-beta and Mx1 mRNA expressions under the stimulation of polyinosinic polycytidylic acid (PolyI:C).	Poly I-C	155-186	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	Gallus gallus	109-112
25135627-4	2014	Here we show that Poly I:C (TLR3 agonist) or R848 (TLR7 agonist) do not activate all endogenous DCs.	Poly I-C	18-26	toll like receptor 3	Homo sapiens	28-32
25009205-6	2014	XCR1(+) DC were strongly activated by polyinosinic-polycytidylic acid but not LPS, and conversely for MoDC.	Poly I-C	38-69	X-C motif chemokine receptor 1	Homo sapiens	0-4
25009205-8	2014	XCR1(+) CD34-DC but not MoDC efficiently cross-presented a cell-associated Ag upon stimulation by polyinosinic-polycytidylic acid or R848, likewise to what was reported for XCR1(+) bDC.	Poly I-C	98-129	X-C motif chemokine receptor 1	Homo sapiens	0-4
25009205-8	2014	XCR1(+) CD34-DC but not MoDC efficiently cross-presented a cell-associated Ag upon stimulation by polyinosinic-polycytidylic acid or R848, likewise to what was reported for XCR1(+) bDC.	Poly I-C	98-129	CD34 molecule	Homo sapiens	8-12
25015821-6	2014	Cells expressing RIPK1 D138N are resistant to TNF- and polyinosinic-polycytidylic acid-induced necroptosis in vitro, and Ripk1(D138N/D138N) mice are protected from TNF-induced shock in vivo.	Poly I-C	55-86	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	17-22
24958904-4	2014	In this study, we assessed the effect of the TLR3 ligand polyinosinic-polycytidylic acid (poly IC) on CD8 T cell immunity and protection elicited by LAIVs.	Poly I-C	57-88	toll-like receptor 3	Mus musculus	45-49
24393484-9	2014	The injections of Poly(I:C) to C57BL/6 mice triggered a thymic overexpression of IFN-beta and IFN-alpha2 associated with increased expressions of CXCL13, CCL21, BAFF, and favored the recruitment of B cells.	Poly I-C	18-27	interferon alpha	Mus musculus	81-89
24393484-9	2014	The injections of Poly(I:C) to C57BL/6 mice triggered a thymic overexpression of IFN-beta and IFN-alpha2 associated with increased expressions of CXCL13, CCL21, BAFF, and favored the recruitment of B cells.	Poly I-C	18-27	interferon alpha 2	Mus musculus	94-104
24393484-9	2014	The injections of Poly(I:C) to C57BL/6 mice triggered a thymic overexpression of IFN-beta and IFN-alpha2 associated with increased expressions of CXCL13, CCL21, BAFF, and favored the recruitment of B cells.	Poly I-C	18-27	chemokine (C-X-C motif) ligand 13	Mus musculus	146-152
24393484-9	2014	The injections of Poly(I:C) to C57BL/6 mice triggered a thymic overexpression of IFN-beta and IFN-alpha2 associated with increased expressions of CXCL13, CCL21, BAFF, and favored the recruitment of B cells.	Poly I-C	18-27	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	161-165
24958904-4	2014	In this study, we assessed the effect of the TLR3 ligand polyinosinic-polycytidylic acid (poly IC) on CD8 T cell immunity and protection elicited by LAIVs.	Poly I-C	90-97	toll-like receptor 3	Mus musculus	45-49
24958904-6	2014	This adjuvant effect of poly IC was dependent on amplification of TLR3 signaling by nonhematopoietic radioresistant cells and enhanced mouse protection to homosubtypic, as well as heterosubtypic, virus challenge.	Poly I-C	24-31	toll-like receptor 3	Mus musculus	66-70
24550525-7	2014	Notably, LRRC33 expression could be down-regulated by TLR ligands LPS, poly I:C, or PGN through H3K4me3 and H3K27me3 modification.	Poly I-C	71-79	negative regulator of reactive oxygen species	Mus musculus	9-15
24999993-7	2014	Knockdown of TRIM68 in primary human monocytes resulted in enhanced levels of type I IFN and TFG following poly(I:C) treatment.	Poly I-C	107-116	tripartite motif containing 68	Homo sapiens	13-19
24999993-7	2014	Knockdown of TRIM68 in primary human monocytes resulted in enhanced levels of type I IFN and TFG following poly(I:C) treatment.	Poly I-C	107-116	trafficking from ER to golgi regulator	Homo sapiens	78-96
24850742-4	2014	In this study, vp13 was found to enhance interferon (IFN) production induced by poly(I   C), a synthetic analog of double-stranded RNA.	Poly I-C	80-91	interferon alpha 1	Homo sapiens	41-57
24850742-5	2014	Poly(I   C) treatment induced a higher level of IFN-beta mRNA in HeLa cells stably expressing vp13 than in control cells.	Poly I-C	0-10	interferon beta 1	Homo sapiens	48-56
24850742-11	2014	In HEV-infected hepatoma cells, wild-type HEV led to a higher level of RIG-I and more poly(I   C)-induced IFN-beta expression than did ORF3-null mutants.	Poly I-C	86-96	interferon beta 1	Homo sapiens	106-114
24811008-6	2014	The expression of Et-TRAF6 was up-regulated in the liver after challenge with Lipoteichoic acid (LTA), Peptidoglycan (PGN), Zymosan, polyinosine-polycytidylic acid [Poly(I:C)] and Polydeoxyadenylic acid   Polythymidylic acid sodium salt [Poly(dA:dT)].	Poly I-C	165-174	TNF receptor associated factor 6	Homo sapiens	18-26
24630834-3	2014	We demonstrated in the present study that polyinosinic-polycytidylic acid (poly IC), an authentic dsRNA, up-regulated the expression of ISG54 and ISG56 in U373MG human astrocytoma cells.	Poly I-C	42-73	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	136-141
24630834-3	2014	We demonstrated in the present study that polyinosinic-polycytidylic acid (poly IC), an authentic dsRNA, up-regulated the expression of ISG54 and ISG56 in U373MG human astrocytoma cells.	Poly I-C	42-73	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	146-151
24630834-3	2014	We demonstrated in the present study that polyinosinic-polycytidylic acid (poly IC), an authentic dsRNA, up-regulated the expression of ISG54 and ISG56 in U373MG human astrocytoma cells.	Poly I-C	75-82	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	136-141
24630834-3	2014	We demonstrated in the present study that polyinosinic-polycytidylic acid (poly IC), an authentic dsRNA, up-regulated the expression of ISG54 and ISG56 in U373MG human astrocytoma cells.	Poly I-C	75-82	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	146-151
24914679-13	2014	Preconditioning with TLR3 ligand Poly I:C increased pIRF3 expression and protected astrocytes against ischemic injury; however, cells treated with a neutralizing antibody against TLR3 lacked the IPC- and Poly I:C-induced ischemic protection and augmentation of IFNbeta.	Poly I-C	33-41	toll-like receptor 3	Mus musculus	21-25
24829411-4	2014	In this study, we demonstrate that Ag targeting to the CD11c(+)CD8(-) DC subpopulation in the presence of stimulating anti-CD40 Ab and TLR3 ligand polyinosinic-polycytidylic acid induces protective responses against rapidly growing tumor cells in naive animals under preventive and therapeutic treatment regimens in vivo.	Poly I-C	147-178	integrin subunit alpha X	Homo sapiens	55-60
24829411-4	2014	In this study, we demonstrate that Ag targeting to the CD11c(+)CD8(-) DC subpopulation in the presence of stimulating anti-CD40 Ab and TLR3 ligand polyinosinic-polycytidylic acid induces protective responses against rapidly growing tumor cells in naive animals under preventive and therapeutic treatment regimens in vivo.	Poly I-C	147-178	CD8a molecule	Homo sapiens	63-66
24829411-4	2014	In this study, we demonstrate that Ag targeting to the CD11c(+)CD8(-) DC subpopulation in the presence of stimulating anti-CD40 Ab and TLR3 ligand polyinosinic-polycytidylic acid induces protective responses against rapidly growing tumor cells in naive animals under preventive and therapeutic treatment regimens in vivo.	Poly I-C	147-178	toll like receptor 3	Homo sapiens	135-139
24915573-1	2014	Systemic administration of polyinosinic:polycytidylic acid (poly I:C), mimics virally-induced activation of TLR3 signalling causing acute small intestine damage, but whether and how mucosal administration of poly I:C causes enteropathy is less clear.	Poly I-C	27-58	toll-like receptor 3	Mus musculus	108-112
24908599-4	2014	Lyophilized polyinosinic-polycytidylic acid [Poly(I:C)] was used to activate TLR3 expressed by OSCC.	Poly I-C	12-43	toll like receptor 3	Homo sapiens	77-81
24908599-4	2014	Lyophilized polyinosinic-polycytidylic acid [Poly(I:C)] was used to activate TLR3 expressed by OSCC.	Poly I-C	45-54	toll like receptor 3	Homo sapiens	77-81
24908599-8	2014	Poly(I:C)-TLR3-induced OSCC cell apoptosis was caspase-3-dependent.	Poly I-C	0-9	toll like receptor 3	Homo sapiens	10-14
24908599-8	2014	Poly(I:C)-TLR3-induced OSCC cell apoptosis was caspase-3-dependent.	Poly I-C	0-9	caspase 3	Homo sapiens	47-56
24915573-1	2014	Systemic administration of polyinosinic:polycytidylic acid (poly I:C), mimics virally-induced activation of TLR3 signalling causing acute small intestine damage, but whether and how mucosal administration of poly I:C causes enteropathy is less clear.	Poly I-C	60-68	toll-like receptor 3	Mus musculus	108-112
24914679-13	2014	Preconditioning with TLR3 ligand Poly I:C increased pIRF3 expression and protected astrocytes against ischemic injury; however, cells treated with a neutralizing antibody against TLR3 lacked the IPC- and Poly I:C-induced ischemic protection and augmentation of IFNbeta.	Poly I-C	33-41	toll-like receptor 3	Mus musculus	179-183
24915573-3	2014	Intraluminal poly I:C induced rapid mucosal immune activation in C57BL/6 mice involving IFNbeta and the CXCL10/CXCR3 axis, that may drive inflammation towards a Th1 profile.	Poly I-C	13-21	chemokine (C-X-C motif) ligand 10	Mus musculus	104-110
24760149-9	2014	Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs.	Poly I-C	0-8	nuclear factor kappa B subunit 1	Homo sapiens	38-47
24915573-3	2014	Intraluminal poly I:C induced rapid mucosal immune activation in C57BL/6 mice involving IFNbeta and the CXCL10/CXCR3 axis, that may drive inflammation towards a Th1 profile.	Poly I-C	13-21	chemokine (C-X-C motif) receptor 3	Mus musculus	111-116
24760149-5	2014	In this study, we examined the effects of polyinosinic-polycytidylic acid [poly(I:C)], a ligand for TLR3, on production of MMPs in human lung fibroblasts, with a focus on nitrosative stress in TLR3 modulation of MMP production.	Poly I-C	42-73	toll like receptor 3	Homo sapiens	100-104
24760149-5	2014	In this study, we examined the effects of polyinosinic-polycytidylic acid [poly(I:C)], a ligand for TLR3, on production of MMPs in human lung fibroblasts, with a focus on nitrosative stress in TLR3 modulation of MMP production.	Poly I-C	42-73	matrix metallopeptidase 1	Homo sapiens	123-127
24760149-5	2014	In this study, we examined the effects of polyinosinic-polycytidylic acid [poly(I:C)], a ligand for TLR3, on production of MMPs in human lung fibroblasts, with a focus on nitrosative stress in TLR3 modulation of MMP production.	Poly I-C	75-84	toll like receptor 3	Homo sapiens	100-104
24760149-9	2014	Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs.	Poly I-C	0-8	interferon regulatory factor 3	Homo sapiens	52-57
24760149-5	2014	In this study, we examined the effects of polyinosinic-polycytidylic acid [poly(I:C)], a ligand for TLR3, on production of MMPs in human lung fibroblasts, with a focus on nitrosative stress in TLR3 modulation of MMP production.	Poly I-C	75-84	matrix metallopeptidase 1	Homo sapiens	123-127
24760149-7	2014	The roles of NF-kappaB and IFN regulatory factor-3 (IRF-3) in the poly(I:C)-mediated production of MMPs and the responsiveness to poly(I:C) of normal lung fibroblasts and asthmatic lung fibroblasts were also investigated.	Poly I-C	66-75	interferon regulatory factor 3	Homo sapiens	27-50
24760149-7	2014	The roles of NF-kappaB and IFN regulatory factor-3 (IRF-3) in the poly(I:C)-mediated production of MMPs and the responsiveness to poly(I:C) of normal lung fibroblasts and asthmatic lung fibroblasts were also investigated.	Poly I-C	66-75	interferon regulatory factor 3	Homo sapiens	52-57
24760149-9	2014	Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs.	Poly I-C	0-8	interferon regulatory factor 3	Homo sapiens	121-126
24760149-7	2014	The roles of NF-kappaB and IFN regulatory factor-3 (IRF-3) in the poly(I:C)-mediated production of MMPs and the responsiveness to poly(I:C) of normal lung fibroblasts and asthmatic lung fibroblasts were also investigated.	Poly I-C	66-75	matrix metallopeptidase 1	Homo sapiens	99-103
24760149-9	2014	Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs.	Poly I-C	0-8	nitric oxide synthase 2	Homo sapiens	176-180
24760149-8	2014	Poly(I:C) augmented production of MMPs and iNOS in fibroblasts, and an iNOS inhibitor diminished this production of MMPs.	Poly I-C	0-8	matrix metallopeptidase 1	Homo sapiens	34-38
24760149-8	2014	Poly(I:C) augmented production of MMPs and iNOS in fibroblasts, and an iNOS inhibitor diminished this production of MMPs.	Poly I-C	0-8	nitric oxide synthase 2	Homo sapiens	43-47
24760149-9	2014	Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs.	Poly I-C	0-8	matrix metallopeptidase 1	Homo sapiens	207-211
24760149-9	2014	Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs.	Poly I-C	141-150	nuclear factor kappa B subunit 1	Homo sapiens	38-47
24760149-9	2014	Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs.	Poly I-C	141-150	interferon regulatory factor 3	Homo sapiens	52-57
24760149-9	2014	Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs.	Poly I-C	141-150	nuclear factor kappa B subunit 1	Homo sapiens	108-117
24760149-9	2014	Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs.	Poly I-C	141-150	interferon regulatory factor 3	Homo sapiens	121-126
24760149-9	2014	Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs.	Poly I-C	141-150	nitric oxide synthase 2	Homo sapiens	176-180
24760149-9	2014	Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs.	Poly I-C	141-150	matrix metallopeptidase 1	Homo sapiens	207-211
24760149-10	2014	Poly(I:C)-induced production of iNOS and MMPs was greater in asthmatic fibroblasts than in normal fibroblasts.	Poly I-C	0-9	nitric oxide synthase 2	Homo sapiens	32-36
24760149-10	2014	Poly(I:C)-induced production of iNOS and MMPs was greater in asthmatic fibroblasts than in normal fibroblasts.	Poly I-C	0-9	matrix metallopeptidase 1	Homo sapiens	41-45
24771854-6	2014	Also, the ability of citrullinated LL-37 to quench macrophage responses to lipoteichoic acid and poly(I:C) signaling via TLR2 and TLR3, respectively, was significantly reduced.	Poly I-C	97-105	cathelicidin antimicrobial peptide	Homo sapiens	35-40
24771854-6	2014	Also, the ability of citrullinated LL-37 to quench macrophage responses to lipoteichoic acid and poly(I:C) signaling via TLR2 and TLR3, respectively, was significantly reduced.	Poly I-C	97-105	toll-like receptor 2	Mus musculus	121-125
24771854-6	2014	Also, the ability of citrullinated LL-37 to quench macrophage responses to lipoteichoic acid and poly(I:C) signaling via TLR2 and TLR3, respectively, was significantly reduced.	Poly I-C	97-105	toll-like receptor 3	Mus musculus	130-134
24782566-3	2014	Human DHX15 contributed to the activation of the NF-kappaB, JNK, and p38 MAPK pathways, but not the IRF3 pathway, in response to the synthetic double-stranded RNA analog poly(I:C) (polyinosinic-polycytidylic acid), and DHX15 was required for optimal cytokine production in response to poly(I:C) and infection with RNA virus.	Poly I-C	181-212	DEAH-box helicase 15	Homo sapiens	6-11
24813850-6	2014	Whereas TNFR-induced RIPK3-dependent necroptosis requires RIPK1, cells lacking RIPK1 were sensitized to necroptosis triggered by poly I:C or interferons.	Poly I-C	129-137	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	79-84
24594387-6	2014	PolyI:C treatment significantly increased the expression levels of Mmp3 mRNA and protein in astrocytes, but not microglia.	Poly I-C	0-7	matrix metallopeptidase 3	Mus musculus	67-71
24594387-7	2014	PolyI:C-ACM was associated with significantly higher Mmp3 protein level and enzyme activity than control-ACM.	Poly I-C	0-7	matrix metallopeptidase 3	Mus musculus	53-57
24036040-0	2014	Suppression of polyI:C-inducible gene expression by EP3 in murine conjunctival epithelium.	Poly I-C	15-22	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	52-55
24780395-5	2014	BAFF was increasingly expressed in presence of TLR4 agonist (lipopolysaccharide, LPS), while TLR2 agonist (Zymosan) and TLR3-agonist (polyinocinic-polycytidykic acid, poly I:C) had no effect on BAFF expression.	Poly I-C	167-175	TNF superfamily member 13b	Homo sapiens	0-4
24729619-0	2014	Polyinosinic-polycytidylic acid has therapeutic effects against cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via TLR3.	Poly I-C	0-31	toll-like receptor 4	Mus musculus	131-135
24729619-0	2014	Polyinosinic-polycytidylic acid has therapeutic effects against cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via TLR3.	Poly I-C	0-31	toll-like receptor 3	Mus musculus	150-154
24729619-1	2014	Recent reports have shown that preconditioning with the TLR3 ligand polyinosinic-polycytidylic acid (poly(I:C)) protects against cerebral ischemia/reperfusion (I/R) injury.	Poly I-C	68-99	toll-like receptor 3	Mus musculus	56-60
24729619-11	2014	Moreover, poly(I:C) treatment attenuated the levels of TNF-alpha and IL-1beta in serum and cerebral spinal fluid of mice stimulated by LPS.	Poly I-C	10-18	tumor necrosis factor	Mus musculus	55-64
24729619-11	2014	Moreover, poly(I:C) treatment attenuated the levels of TNF-alpha and IL-1beta in serum and cerebral spinal fluid of mice stimulated by LPS.	Poly I-C	10-18	interleukin 1 beta	Mus musculus	69-77
24729619-12	2014	However, the protective effects of poly(I:C) against cerebral ischemia were abolished in TLR3(-/-) and TLR4(-/-)mice.	Poly I-C	35-43	toll-like receptor 3	Mus musculus	89-93
24729619-12	2014	However, the protective effects of poly(I:C) against cerebral ischemia were abolished in TLR3(-/-) and TLR4(-/-)mice.	Poly I-C	35-43	toll-like receptor 4	Mus musculus	103-107
24729619-13	2014	Poly(I:C) downregulated TLR4 signaling via TLR3.	Poly I-C	0-8	toll-like receptor 4	Mus musculus	24-28
24729619-13	2014	Poly(I:C) downregulated TLR4 signaling via TLR3.	Poly I-C	0-8	toll-like receptor 3	Mus musculus	43-47
24384468-9	2014	Higher levels of IL-2, IL-5 and IL-6 in plasma and an upregulation of the metabotropic receptor 5 (mGluR5) in foetal brains of 10-day-old offspring prenatally exposed to poly I:C was also observed.	Poly I-C	170-178	interleukin 2	Mus musculus	17-21
24384468-9	2014	Higher levels of IL-2, IL-5 and IL-6 in plasma and an upregulation of the metabotropic receptor 5 (mGluR5) in foetal brains of 10-day-old offspring prenatally exposed to poly I:C was also observed.	Poly I-C	170-178	interleukin 5	Mus musculus	23-27
24384468-9	2014	Higher levels of IL-2, IL-5 and IL-6 in plasma and an upregulation of the metabotropic receptor 5 (mGluR5) in foetal brains of 10-day-old offspring prenatally exposed to poly I:C was also observed.	Poly I-C	170-178	interleukin 6	Mus musculus	32-36
24384468-9	2014	Higher levels of IL-2, IL-5 and IL-6 in plasma and an upregulation of the metabotropic receptor 5 (mGluR5) in foetal brains of 10-day-old offspring prenatally exposed to poly I:C was also observed.	Poly I-C	170-178	glutamate receptor, ionotropic, kainate 1	Mus musculus	99-105
24172847-5	2014	Costimulation with a Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid (poly I:C), significantly accentuated the IL-1alpha-induced inflammatory phenotype in PHLFs, and this effect was blocked with inhibitor of nuclear factor kappa-B kinase subunit beta and TGFbeta-activated kinase-1 inhibitors.	Poly I-C	50-81	interleukin 1 alpha	Homo sapiens	124-133
24172847-5	2014	Costimulation with a Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid (poly I:C), significantly accentuated the IL-1alpha-induced inflammatory phenotype in PHLFs, and this effect was blocked with inhibitor of nuclear factor kappa-B kinase subunit beta and TGFbeta-activated kinase-1 inhibitors.	Poly I-C	50-81	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	268-294
24172847-5	2014	Costimulation with a Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid (poly I:C), significantly accentuated the IL-1alpha-induced inflammatory phenotype in PHLFs, and this effect was blocked with inhibitor of nuclear factor kappa-B kinase subunit beta and TGFbeta-activated kinase-1 inhibitors.	Poly I-C	83-91	interleukin 1 alpha	Homo sapiens	124-133
24172847-5	2014	Costimulation with a Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid (poly I:C), significantly accentuated the IL-1alpha-induced inflammatory phenotype in PHLFs, and this effect was blocked with inhibitor of nuclear factor kappa-B kinase subunit beta and TGFbeta-activated kinase-1 inhibitors.	Poly I-C	83-91	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	268-294
24782566-3	2014	Human DHX15 contributed to the activation of the NF-kappaB, JNK, and p38 MAPK pathways, but not the IRF3 pathway, in response to the synthetic double-stranded RNA analog poly(I:C) (polyinosinic-polycytidylic acid), and DHX15 was required for optimal cytokine production in response to poly(I:C) and infection with RNA virus.	Poly I-C	181-212	nuclear factor kappa B subunit 1	Homo sapiens	49-58
24782566-3	2014	Human DHX15 contributed to the activation of the NF-kappaB, JNK, and p38 MAPK pathways, but not the IRF3 pathway, in response to the synthetic double-stranded RNA analog poly(I:C) (polyinosinic-polycytidylic acid), and DHX15 was required for optimal cytokine production in response to poly(I:C) and infection with RNA virus.	Poly I-C	181-212	mitogen-activated protein kinase 14	Homo sapiens	69-72
24782566-3	2014	Human DHX15 contributed to the activation of the NF-kappaB, JNK, and p38 MAPK pathways, but not the IRF3 pathway, in response to the synthetic double-stranded RNA analog poly(I:C) (polyinosinic-polycytidylic acid), and DHX15 was required for optimal cytokine production in response to poly(I:C) and infection with RNA virus.	Poly I-C	181-212	DEAH-box helicase 15	Homo sapiens	219-224
24736562-4	2014	While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs.	Poly I-C	6-13	interferon gamma	Homo sapiens	81-89
24726876-4	2014	The PP2A-RACK1 complex negatively regulated the IRF3 pathway after LPS or poly(I:C) stimulation or Sendai virus (SeV) infection.	Poly I-C	74-83	protein phosphatase 2 phosphatase activator	Homo sapiens	4-8
24726876-4	2014	The PP2A-RACK1 complex negatively regulated the IRF3 pathway after LPS or poly(I:C) stimulation or Sendai virus (SeV) infection.	Poly I-C	74-83	receptor for activated C kinase 1	Homo sapiens	9-14
24726876-4	2014	The PP2A-RACK1 complex negatively regulated the IRF3 pathway after LPS or poly(I:C) stimulation or Sendai virus (SeV) infection.	Poly I-C	74-83	interferon regulatory factor 3	Homo sapiens	48-52
24736562-4	2014	While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs.	Poly I-C	6-13	C-C motif chemokine ligand 2	Homo sapiens	91-95
24736562-4	2014	While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs.	Poly I-C	6-13	tumor necrosis factor	Homo sapiens	134-142
24736562-4	2014	While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs.	Poly I-C	6-13	C-C motif chemokine ligand 3	Homo sapiens	97-101
24736562-4	2014	While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs.	Poly I-C	6-13	C-C motif chemokine ligand 2	Homo sapiens	154-158
24736562-4	2014	While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs.	Poly I-C	6-13	interleukin 6	Homo sapiens	160-164
24736562-4	2014	While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs.	Poly I-C	6-13	C-X-C motif chemokine ligand 10	Homo sapiens	166-172
24736562-4	2014	While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs.	Poly I-C	6-13	C-C motif chemokine ligand 5	Homo sapiens	174-178
24736562-4	2014	While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs.	Poly I-C	6-13	C-C motif chemokine ligand 4	Homo sapiens	108-112
24736562-5	2014	Both Poly I:C and LPS challenged-corneal cells induced M1 chemotaxis (greatest LPS-PHKF (250%), but down-regulated M1 11beta-HSD1 activity (30 and 40% respectively).	Poly I-C	5-13	RNA, U1 small nuclear 1	Homo sapiens	115-129
24736562-4	2014	While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs.	Poly I-C	6-13	interleukin 6	Homo sapiens	115-118
24736562-4	2014	While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs.	Poly I-C	6-13	C-X-C motif chemokine ligand 10	Homo sapiens	120-126
24736562-4	2014	While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs.	Poly I-C	6-13	C-C motif chemokine ligand 5	Homo sapiens	128-132
24509240-5	2014	Viral replication and expression in this cell type was markedly inhibited by poly(I:C)- or 2-5A-mediated activation of RNase L; however, the inhibition was significantly reversed by RNase L knockdown.	Poly I-C	77-86	ribonuclease L	Homo sapiens	119-126
24677196-3	2014	Studying mice with conditional IFNAR ablations revealed that IFNAR triggering of myeloid cells is essential to protect mice from poly(I:C)-induced liver damage.	Poly I-C	129-138	interferon (alpha and beta) receptor 1	Mus musculus	31-36
25049976-7	2014	Comprehensively considering the results from the two programs, we recommended using the geometric mean of the three genes, TBP, PPIA and B2M, to normalize the gene expression of whole blood and PBMC with poly I:C stimulation.	Poly I-C	204-212	TATA-box binding protein	Homo sapiens	123-126
25049976-7	2014	Comprehensively considering the results from the two programs, we recommended using the geometric mean of the three genes, TBP, PPIA and B2M, to normalize the gene expression of whole blood and PBMC with poly I:C stimulation.	Poly I-C	204-212	peptidylprolyl isomerase A	Homo sapiens	128-132
25049976-7	2014	Comprehensively considering the results from the two programs, we recommended using the geometric mean of the three genes, TBP, PPIA and B2M, to normalize the gene expression of whole blood and PBMC with poly I:C stimulation.	Poly I-C	204-212	beta-2-microglobulin	Homo sapiens	137-140
24452267-2	2014	LEW.1WR1 (but not resistant LEW.1W or WF) rats are susceptible to T1D induced by a TLR3 agonist polyinosinic:polycytidylic acid followed by infection with parvovirus.	Poly I-C	96-127	toll-like receptor 3	Rattus norvegicus	83-87
24677196-3	2014	Studying mice with conditional IFNAR ablations revealed that IFNAR triggering of myeloid cells is essential to protect mice from poly(I:C)-induced liver damage.	Poly I-C	129-138	interferon (alpha and beta) receptor 1	Mus musculus	61-66
24677196-6	2014	Upon poly(I:C) treatment, IFNAR-deficient mice displayed both a severe lack of IL-1RA production and an increased production of proinflammatory IL-1beta, indicating a severely imbalanced cytokine milieu in the liver in absence of a functional type I IFN system.	Poly I-C	5-13	interferon (alpha and beta) receptor 1	Mus musculus	26-31
24677196-6	2014	Upon poly(I:C) treatment, IFNAR-deficient mice displayed both a severe lack of IL-1RA production and an increased production of proinflammatory IL-1beta, indicating a severely imbalanced cytokine milieu in the liver in absence of a functional type I IFN system.	Poly I-C	5-13	interleukin 1 receptor antagonist	Mus musculus	79-85
24677196-6	2014	Upon poly(I:C) treatment, IFNAR-deficient mice displayed both a severe lack of IL-1RA production and an increased production of proinflammatory IL-1beta, indicating a severely imbalanced cytokine milieu in the liver in absence of a functional type I IFN system.	Poly I-C	5-13	interleukin 1 beta	Mus musculus	144-152
24677196-7	2014	Depletion of IL-1beta or treatment with recombinant IL-1RA both rescued IFNAR-deficient mice from poly(I:C)-induced liver damage, directly linking the deregulated IL-1beta and IL-1RA production to liver pathology.	Poly I-C	98-107	interleukin 1 beta	Mus musculus	13-21
24677196-7	2014	Depletion of IL-1beta or treatment with recombinant IL-1RA both rescued IFNAR-deficient mice from poly(I:C)-induced liver damage, directly linking the deregulated IL-1beta and IL-1RA production to liver pathology.	Poly I-C	98-107	interleukin 1 receptor antagonist	Mus musculus	52-58
23839527-2	2014	As shown previously, the RAW 264.7 murine macrophage cell line can release MPs following stimulation with LPS or polyinosinic:polycytidylic acid [poly (I:C)], ligands of TLR4 and TLR3 respectively.	Poly I-C	113-144	toll-like receptor 4	Mus musculus	170-174
23839527-2	2014	As shown previously, the RAW 264.7 murine macrophage cell line can release MPs following stimulation with LPS or polyinosinic:polycytidylic acid [poly (I:C)], ligands of TLR4 and TLR3 respectively.	Poly I-C	113-144	toll-like receptor 3	Mus musculus	179-183
24677196-7	2014	Depletion of IL-1beta or treatment with recombinant IL-1RA both rescued IFNAR-deficient mice from poly(I:C)-induced liver damage, directly linking the deregulated IL-1beta and IL-1RA production to liver pathology.	Poly I-C	98-107	interferon (alpha and beta) receptor 1	Mus musculus	72-77
24677196-7	2014	Depletion of IL-1beta or treatment with recombinant IL-1RA both rescued IFNAR-deficient mice from poly(I:C)-induced liver damage, directly linking the deregulated IL-1beta and IL-1RA production to liver pathology.	Poly I-C	98-107	interleukin 1 beta	Mus musculus	163-171
24677196-7	2014	Depletion of IL-1beta or treatment with recombinant IL-1RA both rescued IFNAR-deficient mice from poly(I:C)-induced liver damage, directly linking the deregulated IL-1beta and IL-1RA production to liver pathology.	Poly I-C	98-107	interleukin 1 receptor antagonist	Mus musculus	176-182
24513039-4	2014	Inflammatory agonists, such as double-stranded RNA mimetics (e.g., poly I:C), stimulate stromal cells, smooth muscle cells and fibroblasts, to produce fibrillar ECMs enriched in versican and hyaluronan (HA) that interact with leukocytes promoting their adhesion.	Poly I-C	67-75	versican	Homo sapiens	178-186
24695077-5	2014	A synthetic double-stranded RNA, polyinosinic-polycytidylic acid (PolyIC), mimics the effects of viruses in various cell types and induces the expression of Gal-9 in endothelial cells.	Poly I-C	33-64	galectin 9	Homo sapiens	157-162
24695077-5	2014	A synthetic double-stranded RNA, polyinosinic-polycytidylic acid (PolyIC), mimics the effects of viruses in various cell types and induces the expression of Gal-9 in endothelial cells.	Poly I-C	66-72	galectin 9	Homo sapiens	157-162
24695077-11	2014	Furthermore, using a human airway epithelial cell line, we showed that the presence of PolyIC but not lipopolysaccharides increased the Gal-9 concentration in the culture medium (p < 0.05), suggesting that PolyIC enhanced Gal-9 production.	Poly I-C	87-93	galectin 9	Homo sapiens	136-141
24695077-11	2014	Furthermore, using a human airway epithelial cell line, we showed that the presence of PolyIC but not lipopolysaccharides increased the Gal-9 concentration in the culture medium (p < 0.05), suggesting that PolyIC enhanced Gal-9 production.	Poly I-C	87-93	galectin 9	Homo sapiens	225-230
24530528-3	2014	MBL interacts with poly(I:C) and suppresses poly(I:C)-induced activation of TLR3 pathways and subsequent cytokine production.	Poly I-C	19-27	mannose binding lectin 2	Homo sapiens	0-3
24530528-3	2014	MBL interacts with poly(I:C) and suppresses poly(I:C)-induced activation of TLR3 pathways and subsequent cytokine production.	Poly I-C	19-27	toll like receptor 3	Homo sapiens	76-80
24530528-3	2014	MBL interacts with poly(I:C) and suppresses poly(I:C)-induced activation of TLR3 pathways and subsequent cytokine production.	Poly I-C	19-28	mannose binding lectin 2	Homo sapiens	0-3
24530528-3	2014	MBL interacts with poly(I:C) and suppresses poly(I:C)-induced activation of TLR3 pathways and subsequent cytokine production.	Poly I-C	19-28	toll like receptor 3	Homo sapiens	76-80
24621600-9	2014	infusion of recombinant IL-1ra completely blocked the poly I:C-induced suppression of spontaneous activity and attenuated amplification of brain interferon (IFN)-alpha expression, which has been reported to produce fatigue-like behavior by suppressing the serotonergic system.	Poly I-C	54-62	interleukin 1 receptor antagonist	Rattus norvegicus	24-30
24113362-9	2014	Furthermore, OAS1a expression was induced in ES/TS co-cultures after poly(I:C) stimulation, but was not induced when either cell type was cultured alone.	Poly I-C	69-77	2'-5' oligoadenylate synthetase 1A	Mus musculus	13-18
24117221-8	2014	A larger sample size would be needed to determine whether the Thr946Ala SNP affects the poly I:C-driven IFN-alpha response.	Poly I-C	88-96	interferon alpha 1	Homo sapiens	104-113
24396068-3	2014	IKK-epsilon was activated following TCR/CD28 stimulation of primary CD4(+) T cells; however, in T cells treated with poly(I C), TCR/CD28 costimulation blocked induction of IFN-beta transcription.	Poly I-C	117-125	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	0-11
24396068-3	2014	IKK-epsilon was activated following TCR/CD28 stimulation of primary CD4(+) T cells; however, in T cells treated with poly(I C), TCR/CD28 costimulation blocked induction of IFN-beta transcription.	Poly I-C	117-125	CD28 molecule	Homo sapiens	132-136
24396068-3	2014	IKK-epsilon was activated following TCR/CD28 stimulation of primary CD4(+) T cells; however, in T cells treated with poly(I C), TCR/CD28 costimulation blocked induction of IFN-beta transcription.	Poly I-C	117-125	interferon beta 1	Homo sapiens	172-180
24453245-7	2014	Although all DC subsets in humanized mice are efficient at presenting peptide to CD8(+) T cells, CD141(+) DC are superior in their capacity to cross-present protein Ag to CD8(+) T cells following activation with polyinosinic-polycytidylic acid.	Poly I-C	212-243	thrombomodulin	Mus musculus	97-102
24491080-3	2014	METHODS: The cell surface expression of TLRs 2-4, TLR7 and TLR9 in HCE and HCF was examined by flow cytometry with or without stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C).	Poly I-C	204-212	toll like receptor 2	Homo sapiens	40-48
24491080-8	2014	Incubation with poly I:C lowered the percentage of HCE cells positive for TLR3 from 10.44% to 2.84% (P < 0.001).	Poly I-C	16-24	toll like receptor 3	Homo sapiens	74-78
24383923-8	2014	Pretreatment with IL-10 or TGF-beta suppressed TLR3-induced miR-155 expression, which itself positively regulated poly I:C-mediated immune responses, thus counteracting IL-10 or TGF-beta-induced immunosuppression.	Poly I-C	114-122	interleukin 10	Homo sapiens	18-23
24321786-4	2014	Stimulation of TLR4 and TLR3 with lipopolysaccharide (LPS) and polyinosinic-polycytidylic acid [poly(I:C)] respectively triggered autophagy in lung cancer cells.	Poly I-C	63-94	toll like receptor 4	Homo sapiens	15-19
24321786-4	2014	Stimulation of TLR4 and TLR3 with lipopolysaccharide (LPS) and polyinosinic-polycytidylic acid [poly(I:C)] respectively triggered autophagy in lung cancer cells.	Poly I-C	63-94	toll like receptor 3	Homo sapiens	24-28
24321786-4	2014	Stimulation of TLR4 and TLR3 with lipopolysaccharide (LPS) and polyinosinic-polycytidylic acid [poly(I:C)] respectively triggered autophagy in lung cancer cells.	Poly I-C	96-105	toll like receptor 4	Homo sapiens	15-19
24321786-4	2014	Stimulation of TLR4 and TLR3 with lipopolysaccharide (LPS) and polyinosinic-polycytidylic acid [poly(I:C)] respectively triggered autophagy in lung cancer cells.	Poly I-C	96-105	toll like receptor 3	Homo sapiens	24-28
23954861-6	2014	Moreover, after poly(I : C) injection, Rip3(-/-) mice displayed decreased levels of pro-inflammatory cytokines (such as TNF-alpha and IL-6) in the retina, and attenuated intravitreal release of high-mobility group box-1 (HMGB1), a major damage-associated molecular pattern (DAMP).	Poly I-C	16-26	receptor-interacting serine-threonine kinase 3	Mus musculus	39-43
23954861-6	2014	Moreover, after poly(I : C) injection, Rip3(-/-) mice displayed decreased levels of pro-inflammatory cytokines (such as TNF-alpha and IL-6) in the retina, and attenuated intravitreal release of high-mobility group box-1 (HMGB1), a major damage-associated molecular pattern (DAMP).	Poly I-C	16-26	tumor necrosis factor	Mus musculus	120-129
23954861-6	2014	Moreover, after poly(I : C) injection, Rip3(-/-) mice displayed decreased levels of pro-inflammatory cytokines (such as TNF-alpha and IL-6) in the retina, and attenuated intravitreal release of high-mobility group box-1 (HMGB1), a major damage-associated molecular pattern (DAMP).	Poly I-C	16-26	interleukin 6	Mus musculus	134-138
23954861-6	2014	Moreover, after poly(I : C) injection, Rip3(-/-) mice displayed decreased levels of pro-inflammatory cytokines (such as TNF-alpha and IL-6) in the retina, and attenuated intravitreal release of high-mobility group box-1 (HMGB1), a major damage-associated molecular pattern (DAMP).	Poly I-C	16-26	high mobility group box 1	Mus musculus	194-219
23954861-6	2014	Moreover, after poly(I : C) injection, Rip3(-/-) mice displayed decreased levels of pro-inflammatory cytokines (such as TNF-alpha and IL-6) in the retina, and attenuated intravitreal release of high-mobility group box-1 (HMGB1), a major damage-associated molecular pattern (DAMP).	Poly I-C	16-26	high mobility group box 1	Mus musculus	221-226
23954861-7	2014	In vitro, poly(I : C)-induced necrosis were inhibited in Rip3-deficient RPE cells, which in turn suppressed HMGB1 release and dampened TNF-alpha and IL-6 induction evoked by necrotic supernatants.	Poly I-C	10-21	receptor-interacting serine-threonine kinase 3	Mus musculus	57-61
23954861-7	2014	In vitro, poly(I : C)-induced necrosis were inhibited in Rip3-deficient RPE cells, which in turn suppressed HMGB1 release and dampened TNF-alpha and IL-6 induction evoked by necrotic supernatants.	Poly I-C	10-21	high mobility group box 1	Mus musculus	108-113
23954861-7	2014	In vitro, poly(I : C)-induced necrosis were inhibited in Rip3-deficient RPE cells, which in turn suppressed HMGB1 release and dampened TNF-alpha and IL-6 induction evoked by necrotic supernatants.	Poly I-C	10-21	tumor necrosis factor	Mus musculus	135-144
23954861-7	2014	In vitro, poly(I : C)-induced necrosis were inhibited in Rip3-deficient RPE cells, which in turn suppressed HMGB1 release and dampened TNF-alpha and IL-6 induction evoked by necrotic supernatants.	Poly I-C	10-21	interleukin 6	Mus musculus	149-153
24014881-3	2014	After poly(I:C) administration, a rapid reduction in parasite burden was observed and proved to be dependent on CD11c(+) cells and TLR3/TRIF signaling.	Poly I-C	6-15	integrin subunit alpha X	Homo sapiens	112-117
24014881-3	2014	After poly(I:C) administration, a rapid reduction in parasite burden was observed and proved to be dependent on CD11c(+) cells and TLR3/TRIF signaling.	Poly I-C	6-15	toll like receptor 3	Homo sapiens	131-135
24014881-3	2014	After poly(I:C) administration, a rapid reduction in parasite burden was observed and proved to be dependent on CD11c(+) cells and TLR3/TRIF signaling.	Poly I-C	6-15	TIR domain containing adaptor molecule 1	Homo sapiens	136-140
24383923-8	2014	Pretreatment with IL-10 or TGF-beta suppressed TLR3-induced miR-155 expression, which itself positively regulated poly I:C-mediated immune responses, thus counteracting IL-10 or TGF-beta-induced immunosuppression.	Poly I-C	114-122	transforming growth factor beta 1	Homo sapiens	27-35
24383923-8	2014	Pretreatment with IL-10 or TGF-beta suppressed TLR3-induced miR-155 expression, which itself positively regulated poly I:C-mediated immune responses, thus counteracting IL-10 or TGF-beta-induced immunosuppression.	Poly I-C	114-122	toll like receptor 3	Homo sapiens	47-51
24383923-8	2014	Pretreatment with IL-10 or TGF-beta suppressed TLR3-induced miR-155 expression, which itself positively regulated poly I:C-mediated immune responses, thus counteracting IL-10 or TGF-beta-induced immunosuppression.	Poly I-C	114-122	microRNA 155	Homo sapiens	60-67
24383923-8	2014	Pretreatment with IL-10 or TGF-beta suppressed TLR3-induced miR-155 expression, which itself positively regulated poly I:C-mediated immune responses, thus counteracting IL-10 or TGF-beta-induced immunosuppression.	Poly I-C	114-122	interleukin 10	Homo sapiens	169-174
24383923-8	2014	Pretreatment with IL-10 or TGF-beta suppressed TLR3-induced miR-155 expression, which itself positively regulated poly I:C-mediated immune responses, thus counteracting IL-10 or TGF-beta-induced immunosuppression.	Poly I-C	114-122	transforming growth factor beta 1	Homo sapiens	178-186
24463573-4	2014	Here we show that oncolytic viruses and adjuvants such as poly(I:C) and CpG induce bystander death of cancer cells treated with SMCs that is mediated by interferon beta (IFN-beta), tumor necrosis factor alpha (TNF-alpha) and/or TNF-related apoptosis-inducing ligand (TRAIL).	Poly I-C	58-67	interferon beta 1	Homo sapiens	153-168
24463573-4	2014	Here we show that oncolytic viruses and adjuvants such as poly(I:C) and CpG induce bystander death of cancer cells treated with SMCs that is mediated by interferon beta (IFN-beta), tumor necrosis factor alpha (TNF-alpha) and/or TNF-related apoptosis-inducing ligand (TRAIL).	Poly I-C	58-67	interferon beta 1	Homo sapiens	170-178
24463573-4	2014	Here we show that oncolytic viruses and adjuvants such as poly(I:C) and CpG induce bystander death of cancer cells treated with SMCs that is mediated by interferon beta (IFN-beta), tumor necrosis factor alpha (TNF-alpha) and/or TNF-related apoptosis-inducing ligand (TRAIL).	Poly I-C	58-67	tumor necrosis factor	Homo sapiens	181-208
24463573-4	2014	Here we show that oncolytic viruses and adjuvants such as poly(I:C) and CpG induce bystander death of cancer cells treated with SMCs that is mediated by interferon beta (IFN-beta), tumor necrosis factor alpha (TNF-alpha) and/or TNF-related apoptosis-inducing ligand (TRAIL).	Poly I-C	58-67	tumor necrosis factor	Homo sapiens	210-219
24463573-4	2014	Here we show that oncolytic viruses and adjuvants such as poly(I:C) and CpG induce bystander death of cancer cells treated with SMCs that is mediated by interferon beta (IFN-beta), tumor necrosis factor alpha (TNF-alpha) and/or TNF-related apoptosis-inducing ligand (TRAIL).	Poly I-C	58-67	TNF superfamily member 10	Homo sapiens	228-265
24463573-4	2014	Here we show that oncolytic viruses and adjuvants such as poly(I:C) and CpG induce bystander death of cancer cells treated with SMCs that is mediated by interferon beta (IFN-beta), tumor necrosis factor alpha (TNF-alpha) and/or TNF-related apoptosis-inducing ligand (TRAIL).	Poly I-C	58-67	TNF superfamily member 10	Homo sapiens	267-272
24423102-5	2014	Poly I:C (TLR3 ligand) was used to trigger TLR3 activation, and mRNA expression of its downstream cytokines interferon (ifn)-beta and tumor necrosis factor (tnf)-alpha was accordingly detected to determine the regulation of TLR3 signaling.	Poly I-C	0-8	toll-like receptor 3	Rattus norvegicus	10-14
24285719-5	2014	Polyinosinic-polycytidylic acid (poly [I:C]) is a common agonist of TLR3, retinoic acid-inducible gene I, and melanoma differentiation-associated gene 5.	Poly I-C	0-31	toll-like receptor 3	Mus musculus	68-72
24285719-5	2014	Polyinosinic-polycytidylic acid (poly [I:C]) is a common agonist of TLR3, retinoic acid-inducible gene I, and melanoma differentiation-associated gene 5.	Poly I-C	0-31	DEAD/H box helicase 58	Mus musculus	74-104
24423102-5	2014	Poly I:C (TLR3 ligand) was used to trigger TLR3 activation, and mRNA expression of its downstream cytokines interferon (ifn)-beta and tumor necrosis factor (tnf)-alpha was accordingly detected to determine the regulation of TLR3 signaling.	Poly I-C	0-8	toll-like receptor 3	Rattus norvegicus	43-47
24423102-5	2014	Poly I:C (TLR3 ligand) was used to trigger TLR3 activation, and mRNA expression of its downstream cytokines interferon (ifn)-beta and tumor necrosis factor (tnf)-alpha was accordingly detected to determine the regulation of TLR3 signaling.	Poly I-C	0-8	tumor necrosis factor	Rattus norvegicus	134-167
24423102-5	2014	Poly I:C (TLR3 ligand) was used to trigger TLR3 activation, and mRNA expression of its downstream cytokines interferon (ifn)-beta and tumor necrosis factor (tnf)-alpha was accordingly detected to determine the regulation of TLR3 signaling.	Poly I-C	0-8	toll-like receptor 3	Rattus norvegicus	43-47
23944933-4	2014	IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway.	Poly I-C	335-342	interleukin 17C	Homo sapiens	0-6
23944933-3	2014	In this study, we demonstrate that polyinosinic-polycytidylic acid (polyI:C), the ligand to Toll-like receptor 3, is a potent inducer of IL-17C mRNA and protein expression in primary normal human bronchial epithelial (NHBE) cells.	Poly I-C	35-66	toll like receptor 3	Homo sapiens	92-112
23944933-4	2014	IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway.	Poly I-C	335-342	TIR domain containing adaptor molecule 1	Homo sapiens	176-180
23944933-3	2014	In this study, we demonstrate that polyinosinic-polycytidylic acid (polyI:C), the ligand to Toll-like receptor 3, is a potent inducer of IL-17C mRNA and protein expression in primary normal human bronchial epithelial (NHBE) cells.	Poly I-C	35-66	interleukin 17C	Homo sapiens	137-143
23944933-3	2014	In this study, we demonstrate that polyinosinic-polycytidylic acid (polyI:C), the ligand to Toll-like receptor 3, is a potent inducer of IL-17C mRNA and protein expression in primary normal human bronchial epithelial (NHBE) cells.	Poly I-C	68-75	toll like receptor 3	Homo sapiens	92-112
23944933-3	2014	In this study, we demonstrate that polyinosinic-polycytidylic acid (polyI:C), the ligand to Toll-like receptor 3, is a potent inducer of IL-17C mRNA and protein expression in primary normal human bronchial epithelial (NHBE) cells.	Poly I-C	68-75	interleukin 17C	Homo sapiens	137-143
23944933-4	2014	IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway.	Poly I-C	20-27	interleukin 17C	Homo sapiens	0-6
23944933-4	2014	IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway.	Poly I-C	20-27	TIR domain containing adaptor molecule 1	Homo sapiens	176-180
23944933-4	2014	IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway.	Poly I-C	20-27	nuclear factor kappa B subunit 1	Homo sapiens	182-191
23944933-4	2014	IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway.	Poly I-C	20-27	TIR domain containing adaptor molecule 1	Homo sapiens	208-212
23944933-4	2014	IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway.	Poly I-C	20-27	nuclear factor kappa B subunit 1	Homo sapiens	221-230
23944933-5	2014	Both IL-17C and polyI:C increased the expression of antimicrobial peptides and proinflammatory cytokines, such as human beta-defensin (hBD) 2, colony-stimulating factor 3 (CSF3), and S100A12 in NHBE cells.	Poly I-C	16-23	defensin beta 4A	Homo sapiens	120-141
23944933-4	2014	IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway.	Poly I-C	20-27	nuclear factor kappa B subunit 1	Homo sapiens	221-230
23944933-4	2014	IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway.	Poly I-C	20-27	RELA proto-oncogene, NF-kB subunit	Homo sapiens	260-263
23944933-5	2014	Both IL-17C and polyI:C increased the expression of antimicrobial peptides and proinflammatory cytokines, such as human beta-defensin (hBD) 2, colony-stimulating factor 3 (CSF3), and S100A12 in NHBE cells.	Poly I-C	16-23	colony stimulating factor 3	Homo sapiens	143-170
23944933-4	2014	IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway.	Poly I-C	20-27	interleukin 17C	Homo sapiens	303-309
23944933-4	2014	IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway.	Poly I-C	20-27	toll like receptor 3	Homo sapiens	351-371
23944933-5	2014	Both IL-17C and polyI:C increased the expression of antimicrobial peptides and proinflammatory cytokines, such as human beta-defensin (hBD) 2, colony-stimulating factor 3 (CSF3), and S100A12 in NHBE cells.	Poly I-C	16-23	colony stimulating factor 3	Homo sapiens	172-176
23944933-4	2014	IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway.	Poly I-C	20-27	TIR domain containing adaptor molecule 1	Homo sapiens	208-212
24060653-8	2014	The expression of glutamate/aspartate transporter (GLAST) in the prefrontal cortex (PFC) was significantly increased in the (PolyI:C/PCP)-treated mice.	Poly I-C	125-132	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	18-49
23944933-4	2014	IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway.	Poly I-C	20-27	nuclear factor kappa B subunit 1	Homo sapiens	221-230
24060653-8	2014	The expression of glutamate/aspartate transporter (GLAST) in the prefrontal cortex (PFC) was significantly increased in the (PolyI:C/PCP)-treated mice.	Poly I-C	125-132	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	51-56
24334148-5	2014	This was associated with a higher responsiveness to poly I:C that resulted in the activation of the TLR3-mediated pathway and the production of inflammatory cytokines in PMS and, in contrast, in the up-regulation of a peculiar mosaic of inflammation-dampening genes in BMS.	Poly I-C	52-60	toll like receptor 3	Homo sapiens	100-104
25204797-5	2014	As TLR3 but not TLR4 signals through the endosomal compartment, flotillin-1 might be involved in the transport of poly-I:C to its receptor.	Poly I-C	114-122	toll like receptor 3	Homo sapiens	3-7
25204797-5	2014	As TLR3 but not TLR4 signals through the endosomal compartment, flotillin-1 might be involved in the transport of poly-I:C to its receptor.	Poly I-C	114-122	flotillin 1	Homo sapiens	64-75
25204797-6	2014	Consistently, uptake of poly-I:C was attenuated by flotillin-1 knockdown and probably involved the scavenger receptor SCARA4 as revealed by knockdown of this receptor.	Poly I-C	24-32	flotillin 1	Homo sapiens	51-62
25204797-6	2014	Consistently, uptake of poly-I:C was attenuated by flotillin-1 knockdown and probably involved the scavenger receptor SCARA4 as revealed by knockdown of this receptor.	Poly I-C	24-32	collectin subfamily member 12	Homo sapiens	118-124
25204797-13	2014	As a consequence, the poly-I:C-induced adhesion of peripheral blood mononuclear cells onto HUVECs was significantly attenuated by flotillin-1 shRNA.	Poly I-C	22-30	flotillin 1	Homo sapiens	130-141
24334148-4	2014	Results showed that, whereas LPS-stimulation of TLR4 had a marginal effect on cell activation, poly I:C-stimulated TLR3 expression on immune cells was significantly increased in PMS and BMS compared to HC.	Poly I-C	95-103	toll like receptor 3	Homo sapiens	115-119
24247593-8	2014	Prestimulation with histamine caused a significant decrease in poly I:C-induced expression of interferon-gamma-induced protein (IP-10) in mDC and monocytes.	Poly I-C	63-71	C-X-C motif chemokine ligand 10	Homo sapiens	94-133
23529855-2	2014	We show here that the activation of TLR3 signaling pathway by poly I:C, a synthetic mimic of dsRNA, could induce high-level expression of interferon (IFN)-lambda1 in a hepatoma cell line.	Poly I-C	62-70	toll like receptor 3	Homo sapiens	36-40
23529855-2	2014	We show here that the activation of TLR3 signaling pathway by poly I:C, a synthetic mimic of dsRNA, could induce high-level expression of interferon (IFN)-lambda1 in a hepatoma cell line.	Poly I-C	62-70	interferon lambda 1	Homo sapiens	138-162
24247593-8	2014	Prestimulation with histamine caused a significant decrease in poly I:C-induced expression of interferon-gamma-induced protein (IP-10) in mDC and monocytes.	Poly I-C	63-71	chemokine (C-C motif) ligand 22	Mus musculus	138-141
23968887-10	2014	Despite their depletion, CD141(+) DCs from explant livers produced markedly increased poly(I:C)-induced IFN lambda (IFN-lambda) compared with donor DCs.	Poly I-C	86-95	thrombomodulin	Homo sapiens	25-30
24372857-4	2014	RESULTS: Peripheral blood monocytes cultured in the presence of GM-CSF and IL-4 were stimulated with polyiosinic-polycytidylic acid [poly (I:C)] or LPS.	Poly I-C	133-143	interleukin 4	Homo sapiens	75-79
24192491-5	2014	Intraperitoneal poly I:C treatment induced MDSC activation, driving CD69 expression and interferon (IFN)-gamma production in NK cells.	Poly I-C	16-24	CD69 antigen	Mus musculus	68-72
24192491-5	2014	Intraperitoneal poly I:C treatment induced MDSC activation, driving CD69 expression and interferon (IFN)-gamma production in NK cells.	Poly I-C	16-24	interferon gamma	Mus musculus	88-110
24372857-4	2014	RESULTS: Peripheral blood monocytes cultured in the presence of GM-CSF and IL-4 were stimulated with polyiosinic-polycytidylic acid [poly (I:C)] or LPS.	Poly I-C	133-143	colony stimulating factor 2	Homo sapiens	64-70
24080550-4	2013	To evaluate the therapeutic potential of NVPP, its effect on signal transduction via the TRIF-dependent pathway of TLRs induced by lipopolysaccharide (LPS) or polyinosinic-polycytidylic acid (poly[I:C]) was examined.	Poly I-C	159-190	TIR domain containing adaptor molecule 1	Homo sapiens	89-93
24244011-8	2013	Expression of all three TNF-alpha isoforms could be modulated by crude LPS, peptidoglycan, polyinosinic:polycytidylic acid, and rIFN-gamma in cell lines and primary macrophages, as well as by bacterial and viral infections.	Poly I-C	91-122	putative tumour necrosis factor alpha	Oncorhynchus mykiss	24-33
24163412-6	2013	Expression of inducible NO synthase was significantly upregulated in PGN+poly(I:C)-treated placenta and uterus.	Poly I-C	73-81	nitric oxide synthase 2, inducible	Mus musculus	14-35
24153332-7	2013	RESULTS: Nasal fibroblasts from the ATA and AIA groups showed significantly enhanced expression of CXCL10 mRNA and protein after poly I:C stimulation compared with cells from the CRS group and the control group (normal nasal mucosa).	Poly I-C	129-137	C-X-C motif chemokine ligand 10	Homo sapiens	99-105
24002868-3	2013	We have used OVA and anti-CD40 to establish a memory CD8(+) T-cell population and report here that their secondary expansion, driven by peptide and anti-CD40, polyI:C, or LPS, requires CD27.	Poly I-C	159-166	CD27 molecule	Homo sapiens	185-189
24184559-7	2013	In addition, a role of CX3CR1 in NK cell trafficking from BM and spleen was evidenced also during inflammation, as CX3CR1-deficient NK cells were more prompt to exit the BM and did not decrease in spleen in response to polyinosinic-polycytidylic acid-promoted hepatitis.	Poly I-C	219-250	C-X3-C motif chemokine receptor 1	Homo sapiens	23-29
24163412-9	2013	Expression of Nlrp3 and activation of caspase-1 were increased in PGN+poly(I:C)-treated uterus, which could induce pyroptosis.	Poly I-C	70-79	NLR family, pyrin domain containing 3	Mus musculus	14-19
24163412-9	2013	Expression of Nlrp3 and activation of caspase-1 were increased in PGN+poly(I:C)-treated uterus, which could induce pyroptosis.	Poly I-C	70-79	caspase 1	Mus musculus	38-47
23736979-2	2013	In this study, we show that porcine CD74 is mainly expressed in cells of the macrophage lineage and can be induced by lipopolysaccharide (LPS), polyinosinic acid-polycytidylic acid [Poly(I:C)], and infection with porcine circovirus type 2 (PCV2) in vitro.	Poly I-C	144-180	CD74 molecule	Homo sapiens	36-40
24067944-9	2013	Interestingly, co-stimulation with LPS or Poly I:C markedly enhanced the immune response against platelet GPIbalpha and caused severe pathology of FNAIT (i.e. miscarriages).	Poly I-C	42-50	glycoprotein 1b, alpha polypeptide	Mus musculus	106-115
24244404-9	2013	Poly(I:C) caused early neutrophilic inflammation through keratinocyte-derived chemokine and granulocyte-macrophage colony-stimulating factor (GM-CSF) release in the lung exposed to CS.	Poly I-C	0-8	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	92-140
24244404-9	2013	Poly(I:C) caused early neutrophilic inflammation through keratinocyte-derived chemokine and granulocyte-macrophage colony-stimulating factor (GM-CSF) release in the lung exposed to CS.	Poly I-C	0-8	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	142-148
24055691-7	2013	Furthermore, polyIC-treated RPE caused a robust stimulation of differentiation of CD4 cell toward Th1 or Th17 cells, in addition to the secretion of the cytokines IFNgamma and IL-17.	Poly I-C	13-19	negative elongation factor complex member C/D, Th1l	Mus musculus	98-101
23876795-2	2013	Previously, we have shown in chicken monocytes that the combination of CpG, the ligand for TLR21 (the chicken equivalent of TLR9), and poly I:C, the ligand for TLR3, results in a synergistic immune response.	Poly I-C	135-143	toll like receptor 3	Gallus gallus	160-164
23738811-7	2013	Our results thus indicate that the systemic neutralization of IL-6 significantly reduces CS/poly(I:C)-induced pulmonary inflammation, which may be a relevant approach to the treatment of episodes of acute pulmonary inflammation associated with COPD.	Poly I-C	92-101	interleukin 6	Mus musculus	62-66
24055691-7	2013	Furthermore, polyIC-treated RPE caused a robust stimulation of differentiation of CD4 cell toward Th1 or Th17 cells, in addition to the secretion of the cytokines IFNgamma and IL-17.	Poly I-C	13-19	interferon gamma	Mus musculus	163-171
24055691-7	2013	Furthermore, polyIC-treated RPE caused a robust stimulation of differentiation of CD4 cell toward Th1 or Th17 cells, in addition to the secretion of the cytokines IFNgamma and IL-17.	Poly I-C	13-19	interleukin 17A	Mus musculus	176-181
23911868-4	2013	Although short poly I:C (  1-1.5 kb) induced greater amounts of TNF-alpha, IL-8, and IFN-beta and a stronger antiviral response in myeloid cells, it was a poor inducer in fibroblasts.	Poly I-C	15-23	tumor necrosis factor	Homo sapiens	64-73
24029594-1	2013	Poly(I:C), an agonist of TLR3 and RLRs, has been used as an immune adjuvant in clinical trials for many years.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	25-29
23911868-4	2013	Although short poly I:C (  1-1.5 kb) induced greater amounts of TNF-alpha, IL-8, and IFN-beta and a stronger antiviral response in myeloid cells, it was a poor inducer in fibroblasts.	Poly I-C	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
23911868-4	2013	Although short poly I:C (  1-1.5 kb) induced greater amounts of TNF-alpha, IL-8, and IFN-beta and a stronger antiviral response in myeloid cells, it was a poor inducer in fibroblasts.	Poly I-C	15-23	interferon beta 1	Homo sapiens	85-93
23911868-8	2013	Finally, long poly I:C required SR-A, whereas short poly I:C required RIG-I and Raftlin.	Poly I-C	52-60	DExD/H-box helicase 58	Homo sapiens	70-75
23911868-8	2013	Finally, long poly I:C required SR-A, whereas short poly I:C required RIG-I and Raftlin.	Poly I-C	52-60	raftlin, lipid raft linker 1	Homo sapiens	80-87
24273253-5	2013	Stimulation of the cells with poly(I:C) lowered the expression of IDO mRNA while IFN-gamma increased its expression.	Poly I-C	30-39	indoleamine 2,3-dioxygenase 1	Homo sapiens	66-69
24286242-13	2013	Exposure to PGN, poly(I:C) or LPS triggered IL-29 production by RA-FLS.	Poly I-C	17-26	interferon lambda 1	Homo sapiens	44-49
24043898-4	2013	NAIP1 is poorly expressed in resting mouse bone marrow-derived macrophages; however, priming with polyinosinic-polycytidylic acid induces it and confers needle protein sensitivity.	Poly I-C	98-129	NLR family, apoptosis inhibitory protein 1	Mus musculus	0-5
24147035-7	2013	We showed that poly I:C administration to C57BL/6 mice rapidly induced IL-7 expression in the salivary glands in a type 1 IFN- and IFN-gamma-dependent manner.	Poly I-C	15-23	interleukin 7	Mus musculus	71-75
24147035-7	2013	We showed that poly I:C administration to C57BL/6 mice rapidly induced IL-7 expression in the salivary glands in a type 1 IFN- and IFN-gamma-dependent manner.	Poly I-C	15-23	interferon gamma	Mus musculus	115-140
24147035-8	2013	Moreover, poly I:C-induced IL-7 contributed to the optimal up-regulation of CXCL9 in the salivary glands, which may subsequently promote recruitment of more IFN-gamma-producing T cells.	Poly I-C	10-18	interleukin 7	Mus musculus	27-31
24147035-8	2013	Moreover, poly I:C-induced IL-7 contributed to the optimal up-regulation of CXCL9 in the salivary glands, which may subsequently promote recruitment of more IFN-gamma-producing T cells.	Poly I-C	10-18	chemokine (C-X-C motif) ligand 9	Mus musculus	76-81
24147035-8	2013	Moreover, poly I:C-induced IL-7 contributed to the optimal up-regulation of CXCL9 in the salivary glands, which may subsequently promote recruitment of more IFN-gamma-producing T cells.	Poly I-C	10-18	interferon gamma	Mus musculus	157-166
24147035-10	2013	Finally, poly I:C or a combination of IFN-alpha and IFN-gamma induced IL-7 gene expression and protein production in a human salivary gland epithelial cell line.	Poly I-C	9-17	interleukin 7	Mus musculus	70-74
24147035-11	2013	Hence, we demonstrate that IL-7 expression in the salivary gland cells can be induced by poly I:C and delineate a crucial mechanism by which innate immune signals facilitate the development of pSS, which is through induction of IL-7 in the target tissues.	Poly I-C	89-97	interleukin 7	Mus musculus	27-31
24147035-11	2013	Hence, we demonstrate that IL-7 expression in the salivary gland cells can be induced by poly I:C and delineate a crucial mechanism by which innate immune signals facilitate the development of pSS, which is through induction of IL-7 in the target tissues.	Poly I-C	89-97	interleukin 7	Mus musculus	228-232
24043902-3	2013	In this study, we show that lithium chloride attenuates LPS-, polyinosinic-polycytidylic acid-, and Sendai virus-induced IFN-beta production and IFN regulatory factor 3 activation in macrophages in a glycogen synthase kinase-3beta-independent manner.	Poly I-C	62-93	interferon beta 1, fibroblast	Mus musculus	121-129
24155891-3	2013	TLR3 is frequently expressed by various types of malignant cells, and recent studies reported that a synthetic TLR3 agonist, polyinosinic-polycytidylic acid [poly(I:C)], induces antitumor effects on malignant cells.	Poly I-C	125-156	toll like receptor 3	Homo sapiens	0-4
24155891-3	2013	TLR3 is frequently expressed by various types of malignant cells, and recent studies reported that a synthetic TLR3 agonist, polyinosinic-polycytidylic acid [poly(I:C)], induces antitumor effects on malignant cells.	Poly I-C	125-156	toll like receptor 3	Homo sapiens	111-115
23810445-4	2013	NVPP suppressed NF-kappaB activation and iNOS expression induced by lipopolysaccharide (TLR4 agonist), polyriboinosinic polyribocytidylic acid (TLR3 agonist), and macrophage-activating lipopeptide 2kDa (TLR2 and TLR6 agonist).	Poly I-C	103-142	nitric oxide synthase 2, inducible	Mus musculus	41-45
23727326-8	2013	TLR3-ligand Poly I:C in combination with IFNgamma were the most potent inducers of IL-32 mRNA expression in both HUVEC and M1/M2 macrophages.	Poly I-C	12-20	toll like receptor 3	Homo sapiens	0-4
23727326-8	2013	TLR3-ligand Poly I:C in combination with IFNgamma were the most potent inducers of IL-32 mRNA expression in both HUVEC and M1/M2 macrophages.	Poly I-C	12-20	interleukin 32	Homo sapiens	83-88
24841667-2	2014	We found that expression levels of TLR3 and IFNalphawere significantly upregulated by PolyI:C, compared to the untreated PK15 cells, which shows that PolyI:C successfully mimics viral infection in PK15 cells.	Poly I-C	86-93	toll-like receptor 3	Sus scrofa	35-39
24841667-2	2014	We found that expression levels of TLR3 and IFNalphawere significantly upregulated by PolyI:C, compared to the untreated PK15 cells, which shows that PolyI:C successfully mimics viral infection in PK15 cells.	Poly I-C	150-157	toll-like receptor 3	Sus scrofa	35-39
24841667-3	2014	We also found that PolyI:C (10 mug/ml) and/or Aza-CdR (5 muM) significantly induces DNA demethylation of porcine CD4, promoting the binding of NF-kappaB to the CpG site on the CD4 promoter and activating expression of CD4.	Poly I-C	19-26	CD4 molecule	Sus scrofa	113-116
24841667-3	2014	We also found that PolyI:C (10 mug/ml) and/or Aza-CdR (5 muM) significantly induces DNA demethylation of porcine CD4, promoting the binding of NF-kappaB to the CpG site on the CD4 promoter and activating expression of CD4.	Poly I-C	19-26	CD4 molecule	Sus scrofa	176-179
24841667-3	2014	We also found that PolyI:C (10 mug/ml) and/or Aza-CdR (5 muM) significantly induces DNA demethylation of porcine CD4, promoting the binding of NF-kappaB to the CpG site on the CD4 promoter and activating expression of CD4.	Poly I-C	19-26	CD4 molecule	Sus scrofa	176-179
23981041-2	2013	Polyinosinic:polycytidylic acid (poly(I:C)) is a viral-mimetic double-stranded RNA complex which activates Toll-Like-Receptor-3 and can activate the metabolism of tryptophan through the oxidative kynurenine pathway to compounds that modulate activity of glutamate receptors.	Poly I-C	0-31	toll-like receptor 3	Rattus norvegicus	107-127
23792113-3	2013	The established assays were used to detect mRNA levels of these inflammation markers and beta-actin in swine testicle (ST) cells transfected with polyinosinic: polycytidylic acid (poly (I:C)).	Poly I-C	146-178	LOC396797	Sus scrofa	89-99
23845419-2	2013	Keratinocytes express high levels of Toll-like receptor 3 (TLR3), and stimulation of the receptor with its ligand polyinosinic-polycytidylic acid (polyI:C) is a powerful signal for release of a variety of proinflammatory cytokines.	Poly I-C	114-145	toll like receptor 3	Homo sapiens	37-57
23845419-2	2013	Keratinocytes express high levels of Toll-like receptor 3 (TLR3), and stimulation of the receptor with its ligand polyinosinic-polycytidylic acid (polyI:C) is a powerful signal for release of a variety of proinflammatory cytokines.	Poly I-C	114-145	toll like receptor 3	Homo sapiens	59-63
23845419-2	2013	Keratinocytes express high levels of Toll-like receptor 3 (TLR3), and stimulation of the receptor with its ligand polyinosinic-polycytidylic acid (polyI:C) is a powerful signal for release of a variety of proinflammatory cytokines.	Poly I-C	147-154	toll like receptor 3	Homo sapiens	37-57
23845419-2	2013	Keratinocytes express high levels of Toll-like receptor 3 (TLR3), and stimulation of the receptor with its ligand polyinosinic-polycytidylic acid (polyI:C) is a powerful signal for release of a variety of proinflammatory cytokines.	Poly I-C	147-154	toll like receptor 3	Homo sapiens	59-63
23845419-4	2013	METHODS: TLR3 in keratinocytes was stimulated with polyI:C.	Poly I-C	51-58	toll like receptor 3	Homo sapiens	9-13
23845419-10	2013	The release of IL-1beta was due to polyI:C induced cell death that occurred through a caspase-4 dependent manner.	Poly I-C	35-42	interleukin 1 beta	Homo sapiens	15-23
23845419-10	2013	The release of IL-1beta was due to polyI:C induced cell death that occurred through a caspase-4 dependent manner.	Poly I-C	35-42	caspase 4	Homo sapiens	86-95
23980209-4	2013	We found that the CD3zeta(-/-) mice can spontaneously develop significant organ inflammation that can be accelerated following the administration of polyinosinic:polycytidylic acid or allogeneic cells (graft versus host).	Poly I-C	149-180	CD247 antigen	Mus musculus	18-25
23978307-7	2013	AMs, but not PMs, demonstrated increased TNFalpha release following stimulation with LPS, polyinosinic polycytidylic acid (Poly IC) and heat-killed Salmonella typhinurium and increased TNFalpha and IDO mRNA expression when stimulated with LPS.	Poly I-C	90-121	tumor necrosis factor	Equus caballus	41-49
23707483-4	2013	We found that adult offspring of poly(I:C)-exposed mothers displayed decreased total levels of AKT protein and reduced phosphorylation at AKT threonine residues in the medial prefrontal cortex.	Poly I-C	33-42	thymoma viral proto-oncogene 1	Mus musculus	95-98
23707483-4	2013	We found that adult offspring of poly(I:C)-exposed mothers displayed decreased total levels of AKT protein and reduced phosphorylation at AKT threonine residues in the medial prefrontal cortex.	Poly I-C	33-42	thymoma viral proto-oncogene 1	Mus musculus	138-141
23956427-6	2013	Surprisingly, the inhibitory effects of poly(I:C) in fibroblasts were independent of TLR3 and were mediated by the cytosolic receptors retinoic acid-inducible gene 1 and melanoma differentiation-associated gene 5, and involved signaling via the IFN receptor.	Poly I-C	40-49	phospholipase A and acyltransferase 4	Homo sapiens	135-212
24069246-4	2013	Here we demonstrated that Poly I:C treatment triggered IL-17A production from hepatic gammadeltaT cells.	Poly I-C	26-34	interleukin 17A	Homo sapiens	55-61
24069246-5	2013	Neutralizing IL-17A by monoclonal antibodies reduced Poly I:C-induced intrahepatic inflammatory responses and the liver injury through decreased accumulation, activation and cytolytic activity of NK cells in the liver.	Poly I-C	53-61	interleukin 17A	Homo sapiens	13-19
24069246-7	2013	Finally, our findings demonstrated a pathological role of IL-17A and gammadeltaT cells in Poly I:C-induced acute hepatitis, which provides novel insights into viral infection-induced hepatitis and may serve as potential target in clinic immunotherapy against these disease.	Poly I-C	90-98	interleukin 17A	Homo sapiens	58-64
24098802-5	2013	Expression of CRACC on NK cells and Kupffer cells was remarkably upregulated after poly I:C injection.	Poly I-C	83-91	SLAM family member 7	Mus musculus	14-19
23956427-4	2013	In explanted skin and lung fibroblasts, the synthetic TLR3 ligand polyinosinic-polycytidylic acid (poly(I:C)), a dsRNA analog, caused dose- and time-dependent stimulation of IFN-beta production and generation of an IFN-response gene signature that was accompanied by substantial downregulation of collagen and alpha-smooth muscle actin gene expression.	Poly I-C	66-97	toll like receptor 3	Homo sapiens	54-58
23956427-4	2013	In explanted skin and lung fibroblasts, the synthetic TLR3 ligand polyinosinic-polycytidylic acid (poly(I:C)), a dsRNA analog, caused dose- and time-dependent stimulation of IFN-beta production and generation of an IFN-response gene signature that was accompanied by substantial downregulation of collagen and alpha-smooth muscle actin gene expression.	Poly I-C	66-97	interferon beta 1	Homo sapiens	174-182
23956427-6	2013	Surprisingly, the inhibitory effects of poly(I:C) in fibroblasts were independent of TLR3 and were mediated by the cytosolic receptors retinoic acid-inducible gene 1 and melanoma differentiation-associated gene 5, and involved signaling via the IFN receptor.	Poly I-C	40-49	interferon alpha 1	Homo sapiens	245-248
23956427-4	2013	In explanted skin and lung fibroblasts, the synthetic TLR3 ligand polyinosinic-polycytidylic acid (poly(I:C)), a dsRNA analog, caused dose- and time-dependent stimulation of IFN-beta production and generation of an IFN-response gene signature that was accompanied by substantial downregulation of collagen and alpha-smooth muscle actin gene expression.	Poly I-C	66-97	interferon alpha 1	Homo sapiens	174-177
24058536-6	2013	The CD1d KO (NKT deficient) mice showed hepatoprotection against poly(I:C)-induced hepatitis in association with increased number of IL-33 expressing hepatocytes in CD1d KO mice than WT controls.	Poly I-C	65-74	CD1d1 antigen	Mus musculus	4-8
23956427-5	2013	Furthermore, poly(I:C) abrogated TGF-beta-induced fibrotic responses and blocked canonical Smad signaling via upregulation of inhibitory Smad7.	Poly I-C	13-21	SMAD family member 7	Homo sapiens	91-95
23956427-5	2013	Furthermore, poly(I:C) abrogated TGF-beta-induced fibrotic responses and blocked canonical Smad signaling via upregulation of inhibitory Smad7.	Poly I-C	13-21	SMAD family member 7	Homo sapiens	137-142
23850521-5	2013	Moreover, inhibitory effects of TLR3 on beta-cell growth were supported by gene silencing of TRIF, which could inhibit p38 activity in response to poly (I:C) stimuli.	Poly I-C	147-156	TIR domain containing adaptor molecule 1	Homo sapiens	93-97
23908180-10	2013	Upon stimulation with R848 or PolyI:C, the levels of IL-17 in the supernatants of naive T cells and monocytes and IL-23 levels in the supernatants of monocytes were not different between BD patients and controls.	Poly I-C	30-37	interleukin 17A	Homo sapiens	53-58
23908180-10	2013	Upon stimulation with R848 or PolyI:C, the levels of IL-17 in the supernatants of naive T cells and monocytes and IL-23 levels in the supernatants of monocytes were not different between BD patients and controls.	Poly I-C	30-37	interleukin 23 subunit alpha	Homo sapiens	114-119
23892079-1	2013	We found in macrophages that IRF3, ERK MAP-kinases, and PKR are essential to NO production in response to RNA-virus mimic, poly I:C, a TLR3 agonist.	Poly I-C	123-131	interferon regulatory factor 3	Homo sapiens	29-33
23892079-1	2013	We found in macrophages that IRF3, ERK MAP-kinases, and PKR are essential to NO production in response to RNA-virus mimic, poly I:C, a TLR3 agonist.	Poly I-C	123-131	mitogen-activated protein kinase 1	Homo sapiens	35-38
23892079-1	2013	We found in macrophages that IRF3, ERK MAP-kinases, and PKR are essential to NO production in response to RNA-virus mimic, poly I:C, a TLR3 agonist.	Poly I-C	123-131	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	56-59
23892079-1	2013	We found in macrophages that IRF3, ERK MAP-kinases, and PKR are essential to NO production in response to RNA-virus mimic, poly I:C, a TLR3 agonist.	Poly I-C	123-131	toll like receptor 3	Homo sapiens	135-139
23850521-3	2013	Activation of TLR3 by polyinosinic-polycytidylic acid [poly (I:C)] was shown to trigger the decline of cyclin D1/2 protein levels in pancreatic beta-cell lines, which could be reversed by the proteasome inhibitor MG132.	Poly I-C	22-53	toll like receptor 3	Homo sapiens	14-18
23850521-3	2013	Activation of TLR3 by polyinosinic-polycytidylic acid [poly (I:C)] was shown to trigger the decline of cyclin D1/2 protein levels in pancreatic beta-cell lines, which could be reversed by the proteasome inhibitor MG132.	Poly I-C	22-53	cyclin D1	Homo sapiens	103-114
23850521-3	2013	Activation of TLR3 by polyinosinic-polycytidylic acid [poly (I:C)] was shown to trigger the decline of cyclin D1/2 protein levels in pancreatic beta-cell lines, which could be reversed by the proteasome inhibitor MG132.	Poly I-C	55-65	toll like receptor 3	Homo sapiens	14-18
23850521-3	2013	Activation of TLR3 by polyinosinic-polycytidylic acid [poly (I:C)] was shown to trigger the decline of cyclin D1/2 protein levels in pancreatic beta-cell lines, which could be reversed by the proteasome inhibitor MG132.	Poly I-C	55-65	cyclin D1	Homo sapiens	103-114
23850521-5	2013	Moreover, inhibitory effects of TLR3 on beta-cell growth were supported by gene silencing of TRIF, which could inhibit p38 activity in response to poly (I:C) stimuli.	Poly I-C	147-156	toll like receptor 3	Homo sapiens	32-36
23850521-5	2013	Moreover, inhibitory effects of TLR3 on beta-cell growth were supported by gene silencing of TRIF, which could inhibit p38 activity in response to poly (I:C) stimuli.	Poly I-C	147-156	mitogen-activated protein kinase 14	Homo sapiens	119-122
23791982-0	2013	Poly(I:C) inhibits porcine reproductive and respiratory syndrome virus replication in MARC-145 cells via activation of IFIT3.	Poly I-C	0-8	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	119-124
23791982-5	2013	In this study, polyinosinic-polycytidylic acid (poly(I:C)) inhibited PRRSV replication in MARC-145 cells, following the appearance of increased IFIT3.	Poly I-C	15-46	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	144-149
23791982-5	2013	In this study, polyinosinic-polycytidylic acid (poly(I:C)) inhibited PRRSV replication in MARC-145 cells, following the appearance of increased IFIT3.	Poly I-C	48-57	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	144-149
23791982-9	2013	IFIT3, TBK1 and phosphorylation of IRF3 were activated in poly(I:C)-transfected MARC-145 cells.	Poly I-C	58-67	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	0-5
23688403-10	2013	The antimycotics itraconazole, ketoconazole, luliconazole, terbinafine, butenafine, and amorolfine suppressed the secretion and mRNA expression of TSLP, NF-kappaB activity, and IkappaBalpha degradation induced by poly I:C plus IL-4.	Poly I-C	213-221	thymic stromal lymphopoietin	Homo sapiens	147-151
23618691-0	2013	Therapeutic potency of Poly I:C in HSV-induced inflammation through up-regulation of IL-15 receptor alpha.	Poly I-C	23-31	interleukin 15	Homo sapiens	85-90
23618691-2	2013	Recent studies informed that polyinosinic:polycytidylic acid (Poly I:C) is an immunostimulant which boosts the generation of memory T cells through induction of IL-15Ralpha.	Poly I-C	29-60	interleukin 15 receptor subunit alpha	Homo sapiens	161-172
23618691-2	2013	Recent studies informed that polyinosinic:polycytidylic acid (Poly I:C) is an immunostimulant which boosts the generation of memory T cells through induction of IL-15Ralpha.	Poly I-C	62-70	interleukin 15 receptor subunit alpha	Homo sapiens	161-172
23618691-5	2013	In addition, Poly I:C supplementation could reduce inflammation through the up-regulation of memory T cells and IL-15Ralpha+ cells accompany with down-regulation of pro-inflammatory cytokine, IL-17A in BD mice.	Poly I-C	13-21	interleukin 15 receptor, alpha chain	Mus musculus	112-123
23618691-5	2013	In addition, Poly I:C supplementation could reduce inflammation through the up-regulation of memory T cells and IL-15Ralpha+ cells accompany with down-regulation of pro-inflammatory cytokine, IL-17A in BD mice.	Poly I-C	13-21	interleukin 17A	Mus musculus	192-198
23872473-3	2013	Exposure to poly I:C and, with lower fold change values, to LPS produced upregulation of the pro- (IL-1beta, IL-8, TNF-alpha) and anti-inflammatory (IL-10) cytokine genes, as well as of the Mx-1 gene.	Poly I-C	12-20	interleukin-1 beta	Oncorhynchus mykiss	99-107
23872473-3	2013	Exposure to poly I:C and, with lower fold change values, to LPS produced upregulation of the pro- (IL-1beta, IL-8, TNF-alpha) and anti-inflammatory (IL-10) cytokine genes, as well as of the Mx-1 gene.	Poly I-C	12-20	putative cxc chemokine	Oncorhynchus mykiss	109-113
23872473-3	2013	Exposure to poly I:C and, with lower fold change values, to LPS produced upregulation of the pro- (IL-1beta, IL-8, TNF-alpha) and anti-inflammatory (IL-10) cytokine genes, as well as of the Mx-1 gene.	Poly I-C	12-20	putative tumour necrosis factor alpha	Oncorhynchus mykiss	115-124
23872473-3	2013	Exposure to poly I:C and, with lower fold change values, to LPS produced upregulation of the pro- (IL-1beta, IL-8, TNF-alpha) and anti-inflammatory (IL-10) cytokine genes, as well as of the Mx-1 gene.	Poly I-C	12-20	interleukin-10	Oncorhynchus mykiss	149-154
23872473-3	2013	Exposure to poly I:C and, with lower fold change values, to LPS produced upregulation of the pro- (IL-1beta, IL-8, TNF-alpha) and anti-inflammatory (IL-10) cytokine genes, as well as of the Mx-1 gene.	Poly I-C	12-20	interferon-induced GTP-binding protein Mx1	Oncorhynchus mykiss	190-194
23820901-8	2013	We also provide evidence that local injection of poly(I:C) induces antiviral response in the testis of TLR3(-/-) mice.	Poly I-C	49-58	toll-like receptor 3	Mus musculus	103-107
23541683-3	2013	Activation of TLR3 by polyinosinic:polycytidylic acid [poly(I:C)] treatment is effective to suppress cell migration and invasion and to decrease organized assembly of F-actin and filopodia formation, in TLR3-expressing SK-N-AS cells, which could be reversed by TLR3-targeting siRNA treatment.	Poly I-C	55-64	toll like receptor 3	Homo sapiens	14-18
23541683-3	2013	Activation of TLR3 by polyinosinic:polycytidylic acid [poly(I:C)] treatment is effective to suppress cell migration and invasion and to decrease organized assembly of F-actin and filopodia formation, in TLR3-expressing SK-N-AS cells, which could be reversed by TLR3-targeting siRNA treatment.	Poly I-C	55-64	toll like receptor 3	Homo sapiens	203-207
23541683-3	2013	Activation of TLR3 by polyinosinic:polycytidylic acid [poly(I:C)] treatment is effective to suppress cell migration and invasion and to decrease organized assembly of F-actin and filopodia formation, in TLR3-expressing SK-N-AS cells, which could be reversed by TLR3-targeting siRNA treatment.	Poly I-C	55-64	toll like receptor 3	Homo sapiens	203-207
23918362-3	2013	We observed that poly(I:C)-induced IRF3 activation in CD8 T cells represses IL-17 expression in a type I IFN-independent fashion.	Poly I-C	17-26	interferon regulatory factor 3	Homo sapiens	35-39
23554175-3	2013	Interferon-beta (IFNbeta) is a primary product of TLR3 activation, and its transcription is elevated in the CNS response to the synthetic TLR3 ligand, polyinosinic-polycytidylic acid (poly(I:C)).	Poly I-C	151-182	interferon beta 1, fibroblast	Mus musculus	0-15
23918362-3	2013	We observed that poly(I:C)-induced IRF3 activation in CD8 T cells represses IL-17 expression in a type I IFN-independent fashion.	Poly I-C	17-26	CD8a molecule	Homo sapiens	54-57
23918362-3	2013	We observed that poly(I:C)-induced IRF3 activation in CD8 T cells represses IL-17 expression in a type I IFN-independent fashion.	Poly I-C	17-26	interleukin 17A	Homo sapiens	76-81
23965176-17	2013	Poly I:C-induced preconditioning against ischemic injury may be mediated by modulation of TLR-3 signaling pathways.	Poly I-C	0-8	toll-like receptor 3	Rattus norvegicus	90-95
23768126-7	2013	Furthermore, poly I:C or CpG encapsulated in Ac-DEX also showed, in general, a significantly stronger immunostimulatory response than PLGA and unencapsulated CpG or poly I:C, which was indicated by a higher rate of nitric oxide release and increased levels of cytokines such as TNF-alpha, IL-6, IL-10, and IFN-gamma.	Poly I-C	13-21	tumor necrosis factor	Homo sapiens	278-287
23768126-7	2013	Furthermore, poly I:C or CpG encapsulated in Ac-DEX also showed, in general, a significantly stronger immunostimulatory response than PLGA and unencapsulated CpG or poly I:C, which was indicated by a higher rate of nitric oxide release and increased levels of cytokines such as TNF-alpha, IL-6, IL-10, and IFN-gamma.	Poly I-C	13-21	interleukin 6	Homo sapiens	289-293
23768126-7	2013	Furthermore, poly I:C or CpG encapsulated in Ac-DEX also showed, in general, a significantly stronger immunostimulatory response than PLGA and unencapsulated CpG or poly I:C, which was indicated by a higher rate of nitric oxide release and increased levels of cytokines such as TNF-alpha, IL-6, IL-10, and IFN-gamma.	Poly I-C	13-21	interleukin 10	Homo sapiens	295-300
23768126-7	2013	Furthermore, poly I:C or CpG encapsulated in Ac-DEX also showed, in general, a significantly stronger immunostimulatory response than PLGA and unencapsulated CpG or poly I:C, which was indicated by a higher rate of nitric oxide release and increased levels of cytokines such as TNF-alpha, IL-6, IL-10, and IFN-gamma.	Poly I-C	13-21	interferon gamma	Homo sapiens	306-315
23554175-3	2013	Interferon-beta (IFNbeta) is a primary product of TLR3 activation, and its transcription is elevated in the CNS response to the synthetic TLR3 ligand, polyinosinic-polycytidylic acid (poly(I:C)).	Poly I-C	151-182	interferon beta 1, fibroblast	Mus musculus	17-24
23554175-3	2013	Interferon-beta (IFNbeta) is a primary product of TLR3 activation, and its transcription is elevated in the CNS response to the synthetic TLR3 ligand, polyinosinic-polycytidylic acid (poly(I:C)).	Poly I-C	151-182	toll-like receptor 3	Mus musculus	50-54
23554175-3	2013	Interferon-beta (IFNbeta) is a primary product of TLR3 activation, and its transcription is elevated in the CNS response to the synthetic TLR3 ligand, polyinosinic-polycytidylic acid (poly(I:C)).	Poly I-C	151-182	toll-like receptor 3	Mus musculus	138-142
23433682-3	2013	To this end, the objective of the study was to gain some further insight into the immunological role of erythrocytes by identifying the repertoire of TLRs that they express and to elucidate their responses to the TLR3 and TLR21 ligands poly I:C and CpG oligodeoxynucleotide (ODN), respectively.	Poly I-C	236-244	toll like receptor 21	Gallus gallus	222-227
23650205-6	2013	Cxcr2(fl/fl) mice were crossed to Mx-Cre mice in which Cre recombinase is induced by Type I interferons, elicited by injection with polyinosinic-polycytidylic acid (poly(I:C)).	Poly I-C	132-163	chemokine (C-X-C motif) receptor 2	Mus musculus	0-5
23648811-9	2013	Double stranded RNA (PolyI:C) stimulates RIG-I dependent signaling; but enhanced cold-shock induced apoptosis.	Poly I-C	21-28	DExD/H-box helicase 58	Homo sapiens	41-46
23648811-10	2013	PolyI:C, but not LAT sncRNAs, interfered with protein synthesis when cotransfected with RIG-I, which correlated with increased levels of cold-shock induced apoptosis.	Poly I-C	0-7	DExD/H-box helicase 58	Homo sapiens	88-93
23640484-9	2013	In vitro studies demonstrated that KRP-203 reduced tumor necrosis factor-alpha, interleukin-6, and interferon-gamma-induced protein-10 production; IkappaB and signal transducer and activator of transcription-1 phosphorylation; and nuclear factor kappaB and signal transducer and activator of transcription-1 activation in poly(I:C)-, lipopolysaccharide-, or interferon-gamma-stimulated bone marrow macrophages, respectively.	Poly I-C	322-331	spermatogenesis associated 6	Mus musculus	35-38
23864690-6	2013	The sensitizing effect of Poly I:C was specific for the TLR-3 pathway because mice deficient in the TLR-3 adaptor protein Toll/IL-1R domain-containing adaptor molecule-1 (TRIF) did not develop larger brain damage.	Poly I-C	26-34	toll-like receptor 3	Mus musculus	56-61
23864690-6	2013	The sensitizing effect of Poly I:C was specific for the TLR-3 pathway because mice deficient in the TLR-3 adaptor protein Toll/IL-1R domain-containing adaptor molecule-1 (TRIF) did not develop larger brain damage.	Poly I-C	26-34	toll-like receptor 3	Mus musculus	100-105
23907982-10	2013	PIC-induced behavioral deficits were abolished by IL-6 antibodies and were mimicked by recombinant IL-6; IL-1beta was not involved.	Poly I-C	0-3	interleukin 6	Mus musculus	50-54
23907982-10	2013	PIC-induced behavioral deficits were abolished by IL-6 antibodies and were mimicked by recombinant IL-6; IL-1beta was not involved.	Poly I-C	0-3	interleukin 6	Mus musculus	99-103
23844087-3	2013	Placental miR-210 levels were increased significantly in pregnant mice treated with the TLR3 agonist poly I:C (P-PIC).	Poly I-C	101-109	microRNA 210	Mus musculus	10-17
23844087-3	2013	Placental miR-210 levels were increased significantly in pregnant mice treated with the TLR3 agonist poly I:C (P-PIC).	Poly I-C	101-109	toll-like receptor 3	Mus musculus	88-92
23844087-3	2013	Placental miR-210 levels were increased significantly in pregnant mice treated with the TLR3 agonist poly I:C (P-PIC).	Poly I-C	101-109	peptidylprolyl isomerase C	Mus musculus	111-116
23844087-8	2013	To determine the placental etiology, treatment of human CTBs with poly I:C significantly increased HIF-1alpha, NF-kappaBp50, and miR-210 levels and decreased STAT6 and IL-4 levels.	Poly I-C	66-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109
23844087-8	2013	To determine the placental etiology, treatment of human CTBs with poly I:C significantly increased HIF-1alpha, NF-kappaBp50, and miR-210 levels and decreased STAT6 and IL-4 levels.	Poly I-C	66-74	nuclear factor kappa B subunit 1	Homo sapiens	111-123
23844087-8	2013	To determine the placental etiology, treatment of human CTBs with poly I:C significantly increased HIF-1alpha, NF-kappaBp50, and miR-210 levels and decreased STAT6 and IL-4 levels.	Poly I-C	66-74	microRNA 210	Homo sapiens	129-136
23844087-8	2013	To determine the placental etiology, treatment of human CTBs with poly I:C significantly increased HIF-1alpha, NF-kappaBp50, and miR-210 levels and decreased STAT6 and IL-4 levels.	Poly I-C	66-74	signal transducer and activator of transcription 6	Homo sapiens	158-163
23844087-8	2013	To determine the placental etiology, treatment of human CTBs with poly I:C significantly increased HIF-1alpha, NF-kappaBp50, and miR-210 levels and decreased STAT6 and IL-4 levels.	Poly I-C	66-74	interleukin 4	Homo sapiens	168-172
23640484-9	2013	In vitro studies demonstrated that KRP-203 reduced tumor necrosis factor-alpha, interleukin-6, and interferon-gamma-induced protein-10 production; IkappaB and signal transducer and activator of transcription-1 phosphorylation; and nuclear factor kappaB and signal transducer and activator of transcription-1 activation in poly(I:C)-, lipopolysaccharide-, or interferon-gamma-stimulated bone marrow macrophages, respectively.	Poly I-C	322-331	tumor necrosis factor	Mus musculus	51-78
23640484-9	2013	In vitro studies demonstrated that KRP-203 reduced tumor necrosis factor-alpha, interleukin-6, and interferon-gamma-induced protein-10 production; IkappaB and signal transducer and activator of transcription-1 phosphorylation; and nuclear factor kappaB and signal transducer and activator of transcription-1 activation in poly(I:C)-, lipopolysaccharide-, or interferon-gamma-stimulated bone marrow macrophages, respectively.	Poly I-C	322-331	interferon gamma	Mus musculus	99-115
23348232-3	2013	METHODS: A/J mice were given polyinosinic-polycytidylic acid (poly[I:C]), a TLR3 agonist, intranasally, in the presence or absence of cigarette smoke exposure.	Poly I-C	29-60	toll-like receptor 3	Mus musculus	76-80
23521925-4	2013	We found that white blood cells from LMN horses produced more IFNgamma than did cells from CON horses when stimulated in vitro with polyinosinic-polycytidylic acid [poly(I:C)], possibly due to an elevated number of circulating monocytes.	Poly I-C	132-163	interferon gamma	Equus caballus	62-70
23806456-7	2013	Coculture of eosinophils resulted in suppression of poly(I:C)-stimulated IFN-beta1 and IFN-lambda1 mRNA expression (2.5-fold and 3.6-fold less, respectively).	Poly I-C	52-61	interferon lambda 1	Homo sapiens	87-98
23777496-4	2013	THP-1 cells were preincubated with CsA, then stimulated with lipopolysaccharide (LPS), polyinosinic:polycytidylic acid or adenosine triphosphate.	Poly I-C	87-118	GLI family zinc finger 2	Homo sapiens	0-5
23083640-4	2013	Having developed a murine double injury model of cecal ligation and puncture (CLP) followed by Pseudomonas aeruginosa (Pa), we hypothesized that targeted administration of Poly I:C, a TLR3 agonist, would protect mice against secondary pneumonia.	Poly I-C	172-180	toll-like receptor 3	Mus musculus	184-188
23083640-10	2013	Measurements of TLR3 expression showed significant increases within both the immune and lung epithelial cells of Poly I:C-treated mice.	Poly I-C	113-121	toll-like receptor 3	Mus musculus	16-20
23567548-4	2013	Polyinosinic-polycytidylic acid [poly(I:C)], a common agonist of TLR3, MDA5 and RIG-I, induced innate antiviral responses in ovarian granulosa cells.	Poly I-C	0-31	toll-like receptor 3	Mus musculus	65-69
23567548-4	2013	Polyinosinic-polycytidylic acid [poly(I:C)], a common agonist of TLR3, MDA5 and RIG-I, induced innate antiviral responses in ovarian granulosa cells.	Poly I-C	0-31	interferon induced with helicase C domain 1	Mus musculus	71-75
23567548-4	2013	Polyinosinic-polycytidylic acid [poly(I:C)], a common agonist of TLR3, MDA5 and RIG-I, induced innate antiviral responses in ovarian granulosa cells.	Poly I-C	0-31	DEAD/H box helicase 58	Mus musculus	80-85
23567548-4	2013	Polyinosinic-polycytidylic acid [poly(I:C)], a common agonist of TLR3, MDA5 and RIG-I, induced innate antiviral responses in ovarian granulosa cells.	Poly I-C	33-42	toll-like receptor 3	Mus musculus	65-69
23567548-4	2013	Polyinosinic-polycytidylic acid [poly(I:C)], a common agonist of TLR3, MDA5 and RIG-I, induced innate antiviral responses in ovarian granulosa cells.	Poly I-C	33-42	interferon induced with helicase C domain 1	Mus musculus	71-75
23521925-4	2013	We found that white blood cells from LMN horses produced more IFNgamma than did cells from CON horses when stimulated in vitro with polyinosinic-polycytidylic acid [poly(I:C)], possibly due to an elevated number of circulating monocytes.	Poly I-C	165-174	interferon gamma	Equus caballus	62-70
23567548-4	2013	Polyinosinic-polycytidylic acid [poly(I:C)], a common agonist of TLR3, MDA5 and RIG-I, induced innate antiviral responses in ovarian granulosa cells.	Poly I-C	33-42	DEAD/H box helicase 58	Mus musculus	80-85
23534905-8	2013	Interestingly, IkappaB-alpha inhibitor (BAY11-7082) or nuclear factor kappa B (NF-kappaB) inhibitor (quinazoline) blocked NF-kappaB p65 protein nuclear translocation, and also suppressed IL-32 production induced by polyI:C or flagellin.	Poly I-C	215-222	NFKB inhibitor alpha	Homo sapiens	15-28
23567548-8	2013	The poly(I:C)-induced antiviral responses in TLR3 knockout (TLR3(-/-)) ovarian granulosa cells were reduced, and completely abolished by blocking of MDA5/RIG-I signaling.	Poly I-C	4-12	toll-like receptor 3	Mus musculus	45-49
23567548-8	2013	The poly(I:C)-induced antiviral responses in TLR3 knockout (TLR3(-/-)) ovarian granulosa cells were reduced, and completely abolished by blocking of MDA5/RIG-I signaling.	Poly I-C	4-12	toll-like receptor 3	Mus musculus	60-64
23567548-8	2013	The poly(I:C)-induced antiviral responses in TLR3 knockout (TLR3(-/-)) ovarian granulosa cells were reduced, and completely abolished by blocking of MDA5/RIG-I signaling.	Poly I-C	4-12	interferon induced with helicase C domain 1	Mus musculus	149-153
23567548-8	2013	The poly(I:C)-induced antiviral responses in TLR3 knockout (TLR3(-/-)) ovarian granulosa cells were reduced, and completely abolished by blocking of MDA5/RIG-I signaling.	Poly I-C	4-12	DEAD/H box helicase 58	Mus musculus	154-159
23534905-6	2013	RESULTS: IL-32 mRNA and protein were largely induced by specific microbial components, including polyinosinic-polycytidylic acid (polyI:C) and flagellin, the ligands to TLR3 and TLR5 respectively, in human corneal epithelium ex vivo and in vitro cultures.	Poly I-C	97-128	interleukin 32	Homo sapiens	9-14
23534905-8	2013	Interestingly, IkappaB-alpha inhibitor (BAY11-7082) or nuclear factor kappa B (NF-kappaB) inhibitor (quinazoline) blocked NF-kappaB p65 protein nuclear translocation, and also suppressed IL-32 production induced by polyI:C or flagellin.	Poly I-C	215-222	nuclear factor kappa B subunit 1	Homo sapiens	55-77
23534905-6	2013	RESULTS: IL-32 mRNA and protein were largely induced by specific microbial components, including polyinosinic-polycytidylic acid (polyI:C) and flagellin, the ligands to TLR3 and TLR5 respectively, in human corneal epithelium ex vivo and in vitro cultures.	Poly I-C	97-128	toll like receptor 3	Homo sapiens	169-173
23534905-8	2013	Interestingly, IkappaB-alpha inhibitor (BAY11-7082) or nuclear factor kappa B (NF-kappaB) inhibitor (quinazoline) blocked NF-kappaB p65 protein nuclear translocation, and also suppressed IL-32 production induced by polyI:C or flagellin.	Poly I-C	215-222	nuclear factor kappa B subunit 1	Homo sapiens	79-88
23534905-6	2013	RESULTS: IL-32 mRNA and protein were largely induced by specific microbial components, including polyinosinic-polycytidylic acid (polyI:C) and flagellin, the ligands to TLR3 and TLR5 respectively, in human corneal epithelium ex vivo and in vitro cultures.	Poly I-C	97-128	toll like receptor 5	Homo sapiens	178-182
23534905-8	2013	Interestingly, IkappaB-alpha inhibitor (BAY11-7082) or nuclear factor kappa B (NF-kappaB) inhibitor (quinazoline) blocked NF-kappaB p65 protein nuclear translocation, and also suppressed IL-32 production induced by polyI:C or flagellin.	Poly I-C	215-222	nuclear factor kappa B subunit 1	Homo sapiens	122-131
23534905-6	2013	RESULTS: IL-32 mRNA and protein were largely induced by specific microbial components, including polyinosinic-polycytidylic acid (polyI:C) and flagellin, the ligands to TLR3 and TLR5 respectively, in human corneal epithelium ex vivo and in vitro cultures.	Poly I-C	130-137	interleukin 32	Homo sapiens	9-14
23534905-8	2013	Interestingly, IkappaB-alpha inhibitor (BAY11-7082) or nuclear factor kappa B (NF-kappaB) inhibitor (quinazoline) blocked NF-kappaB p65 protein nuclear translocation, and also suppressed IL-32 production induced by polyI:C or flagellin.	Poly I-C	215-222	RELA proto-oncogene, NF-kB subunit	Homo sapiens	132-135
23534905-6	2013	RESULTS: IL-32 mRNA and protein were largely induced by specific microbial components, including polyinosinic-polycytidylic acid (polyI:C) and flagellin, the ligands to TLR3 and TLR5 respectively, in human corneal epithelium ex vivo and in vitro cultures.	Poly I-C	130-137	toll like receptor 3	Homo sapiens	169-173
23534905-7	2013	The polyI:C-induced IL-32 production was blocked by TLR3 antibody or TRIF inhibitory peptide, while flagellin-stimulated IL-32 was blocked by TLR5 antibody or MyD88 inhibitory peptide.	Poly I-C	4-11	interleukin 32	Homo sapiens	20-25
23534905-8	2013	Interestingly, IkappaB-alpha inhibitor (BAY11-7082) or nuclear factor kappa B (NF-kappaB) inhibitor (quinazoline) blocked NF-kappaB p65 protein nuclear translocation, and also suppressed IL-32 production induced by polyI:C or flagellin.	Poly I-C	215-222	interleukin 32	Homo sapiens	187-192
23534905-7	2013	The polyI:C-induced IL-32 production was blocked by TLR3 antibody or TRIF inhibitory peptide, while flagellin-stimulated IL-32 was blocked by TLR5 antibody or MyD88 inhibitory peptide.	Poly I-C	4-11	toll like receptor 3	Homo sapiens	52-56
23534905-7	2013	The polyI:C-induced IL-32 production was blocked by TLR3 antibody or TRIF inhibitory peptide, while flagellin-stimulated IL-32 was blocked by TLR5 antibody or MyD88 inhibitory peptide.	Poly I-C	4-11	TIR domain containing adaptor molecule 1	Homo sapiens	69-73
23182713-9	2013	The induction of the JLP protein expression was observed in the LPS-mature DC that were activated by CD40 ligation, and also in the poly I:C stimulated DC.	Poly I-C	132-140	sperm associated antigen 9	Homo sapiens	21-24
23232980-2	2013	Increased NF-kappaB and Stat3 phosphorylation were detected after poly I:C exposure and pretreatment with neutralizing antibody targeting IL-6 receptor alpha (IL-6Ralpha -nAb) or blocking Jak2 and Stat3 activity inhibited Stat3 phosphorylation.	Poly I-C	66-74	signal transducer and activator of transcription 3	Homo sapiens	24-29
23232980-2	2013	Increased NF-kappaB and Stat3 phosphorylation were detected after poly I:C exposure and pretreatment with neutralizing antibody targeting IL-6 receptor alpha (IL-6Ralpha -nAb) or blocking Jak2 and Stat3 activity inhibited Stat3 phosphorylation.	Poly I-C	66-74	signal transducer and activator of transcription 3	Homo sapiens	197-202
23232980-2	2013	Increased NF-kappaB and Stat3 phosphorylation were detected after poly I:C exposure and pretreatment with neutralizing antibody targeting IL-6 receptor alpha (IL-6Ralpha -nAb) or blocking Jak2 and Stat3 activity inhibited Stat3 phosphorylation.	Poly I-C	66-74	signal transducer and activator of transcription 3	Homo sapiens	197-202
23232980-3	2013	TLR2 up-regulation by poly I:C was also reduced by IL-6Ralpha-nAb and inhibitors of Jak2, Stat3 and NF-kappaB phosphorylation, whereas RANTES secretion was unaffected, but abolished following NF-kappaB inhibition.	Poly I-C	22-30	toll like receptor 2	Homo sapiens	0-4
23232980-3	2013	TLR2 up-regulation by poly I:C was also reduced by IL-6Ralpha-nAb and inhibitors of Jak2, Stat3 and NF-kappaB phosphorylation, whereas RANTES secretion was unaffected, but abolished following NF-kappaB inhibition.	Poly I-C	22-30	interleukin 6 receptor	Homo sapiens	51-61
23232980-3	2013	TLR2 up-regulation by poly I:C was also reduced by IL-6Ralpha-nAb and inhibitors of Jak2, Stat3 and NF-kappaB phosphorylation, whereas RANTES secretion was unaffected, but abolished following NF-kappaB inhibition.	Poly I-C	22-30	Janus kinase 2	Homo sapiens	84-88
23232980-3	2013	TLR2 up-regulation by poly I:C was also reduced by IL-6Ralpha-nAb and inhibitors of Jak2, Stat3 and NF-kappaB phosphorylation, whereas RANTES secretion was unaffected, but abolished following NF-kappaB inhibition.	Poly I-C	22-30	signal transducer and activator of transcription 3	Homo sapiens	90-95
23430582-4	2013	We found that E7(44-62) with poly(I:C) treatment markedly increased TLR3 expression and cytotoxicity against HeLa cells in human NK92 cells.	Poly I-C	29-38	toll like receptor 3	Homo sapiens	68-72
23580653-5	2013	The failure of mESCs to express IFNalpha/beta was further demonstrated by treatment with polyIC, a synthetic viral dsRNA analog that strongly induced IFNalpha/beta in 10T1/2 cells.	Poly I-C	89-95	interferon beta 1, fibroblast	Mus musculus	150-163
23262434-4	2013	RESULTS: Mice injected with polyIC developed significant proteinuria with increased urinary CD80 excretion.	Poly I-C	28-34	CD80 antigen	Mus musculus	92-96
23262434-5	2013	Glomeruli from mice injected with polyIC were normal by light microscopic examination, but showed increased CD80 production in podocytes by immunofluorescence staining.	Poly I-C	34-40	CD80 antigen	Mus musculus	108-112
23262434-7	2013	CONCLUSIONS: Our study demonstrates that systemically administered polyIC can induce transient proteinuria and urinary CD80 excretion with an increase in CD80 production in podocytes, increased glomerular CD80 and reduced synaptopodin expression.	Poly I-C	67-73	CD80 antigen	Mus musculus	119-123
23262434-7	2013	CONCLUSIONS: Our study demonstrates that systemically administered polyIC can induce transient proteinuria and urinary CD80 excretion with an increase in CD80 production in podocytes, increased glomerular CD80 and reduced synaptopodin expression.	Poly I-C	67-73	CD80 antigen	Mus musculus	154-158
23542035-2	2013	We show that sustained LPS or poly(I:C)-stimulated MCP-1 production requires an IFNbeta-mediated feedback loop.	Poly I-C	30-39	C-C motif chemokine ligand 2	Homo sapiens	51-56
23262434-7	2013	CONCLUSIONS: Our study demonstrates that systemically administered polyIC can induce transient proteinuria and urinary CD80 excretion with an increase in CD80 production in podocytes, increased glomerular CD80 and reduced synaptopodin expression.	Poly I-C	67-73	CD80 antigen	Mus musculus	154-158
23660190-4	2013	The stimulation of cultured airway epithelial cells with an analog of viral dsRNA, polyinosinic-polycytidylic acid (poly IC) upregulates the expression of B7-H1 via activation of the nuclear factor kappaB(NF-kappaB).	Poly I-C	83-114	CD274 molecule	Homo sapiens	155-160
23660190-4	2013	The stimulation of cultured airway epithelial cells with an analog of viral dsRNA, polyinosinic-polycytidylic acid (poly IC) upregulates the expression of B7-H1 via activation of the nuclear factor kappaB(NF-kappaB).	Poly I-C	83-114	nuclear factor kappa B subunit 1	Homo sapiens	205-214
23660190-4	2013	The stimulation of cultured airway epithelial cells with an analog of viral dsRNA, polyinosinic-polycytidylic acid (poly IC) upregulates the expression of B7-H1 via activation of the nuclear factor kappaB(NF-kappaB).	Poly I-C	116-123	CD274 molecule	Homo sapiens	155-160
23660190-4	2013	The stimulation of cultured airway epithelial cells with an analog of viral dsRNA, polyinosinic-polycytidylic acid (poly IC) upregulates the expression of B7-H1 via activation of the nuclear factor kappaB(NF-kappaB).	Poly I-C	116-123	nuclear factor kappa B subunit 1	Homo sapiens	205-214
23660190-6	2013	Poly IC-induced upregulation of B7-H1 was profoundly suppressed by a pan-PI3K inhibitor and partially by an inhibitor or a small interfering (si)RNA for PI3Kdelta in BEAS-2B cells.	Poly I-C	0-7	CD274 molecule	Homo sapiens	32-37
23660190-6	2013	Poly IC-induced upregulation of B7-H1 was profoundly suppressed by a pan-PI3K inhibitor and partially by an inhibitor or a small interfering (si)RNA for PI3Kdelta in BEAS-2B cells.	Poly I-C	0-7	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	153-162
23660190-11	2013	Poly IC-induced upregulation of B7-H1 was attenuated by N-acetyl-L-cysteine, an antioxidant, or by oxypurinol, an inhibitor of xanthine oxidase.	Poly I-C	0-7	CD274 molecule	Homo sapiens	32-37
23660190-12	2013	Poly IC-induced activation of NF-kappaB was suppressed by a pan-PI3K inhibitor but not by a PI3Kdelta inhibitor.	Poly I-C	0-7	nuclear factor kappa B subunit 1	Homo sapiens	30-39
23542035-2	2013	We show that sustained LPS or poly(I:C)-stimulated MCP-1 production requires an IFNbeta-mediated feedback loop.	Poly I-C	30-39	interferon beta 1	Homo sapiens	80-87
23671710-3	2013	Here we show that expression of LGP2 potentiates IFN induction by polyinosinic-polycytidylic acid [poly(I:C)], commonly used as a synthetic mimic of viral dsRNA, and that this is particularly significant at limited levels of the inducer.	Poly I-C	66-97	DExH-box helicase 58	Homo sapiens	32-36
23671710-3	2013	Here we show that expression of LGP2 potentiates IFN induction by polyinosinic-polycytidylic acid [poly(I:C)], commonly used as a synthetic mimic of viral dsRNA, and that this is particularly significant at limited levels of the inducer.	Poly I-C	66-97	interferon alpha 1	Homo sapiens	49-52
23335246-12	2013	Poly(I-C)-treated mice showed high levels of cutaneous TSLP.	Poly I-C	0-9	thymic stromal lymphopoietin	Mus musculus	55-59
23671710-3	2013	Here we show that expression of LGP2 potentiates IFN induction by polyinosinic-polycytidylic acid [poly(I:C)], commonly used as a synthetic mimic of viral dsRNA, and that this is particularly significant at limited levels of the inducer.	Poly I-C	99-108	DExH-box helicase 58	Homo sapiens	32-36
23671710-3	2013	Here we show that expression of LGP2 potentiates IFN induction by polyinosinic-polycytidylic acid [poly(I:C)], commonly used as a synthetic mimic of viral dsRNA, and that this is particularly significant at limited levels of the inducer.	Poly I-C	99-108	interferon alpha 1	Homo sapiens	49-52
23850670-4	2013	Polyinosinic-polycytidylic acid (Poly I:C), which is a TLR3 agonist, stimulation could moderately induce CCL20 production in HGFs.	Poly I-C	0-31	toll like receptor 3	Homo sapiens	55-59
23402795-4	2013	Using Western blot analysis, we detected global hypoacetylation of histone H3, at lysine residues 9 and 14, and histone H4, at lysine residue 8, in the cortex from juvenile (~24days of age) offspring exposed to polyI:C in utero, but not from adult (3months of age) offspring, which exhibit significant behavioral abnormalities.	Poly I-C	211-218	H3 clustered histone 7	Mus musculus	67-77
23402795-4	2013	Using Western blot analysis, we detected global hypoacetylation of histone H3, at lysine residues 9 and 14, and histone H4, at lysine residue 8, in the cortex from juvenile (~24days of age) offspring exposed to polyI:C in utero, but not from adult (3months of age) offspring, which exhibit significant behavioral abnormalities.	Poly I-C	211-218	LOC102641229	Mus musculus	112-122
23850670-4	2013	Polyinosinic-polycytidylic acid (Poly I:C), which is a TLR3 agonist, stimulation could moderately induce CCL20 production in HGFs.	Poly I-C	0-31	C-C motif chemokine ligand 20	Homo sapiens	105-110
23850670-5	2013	Poly I:C synergistically enhanced CCL20 expression from IL-1beta-stimulated HGFs.	Poly I-C	0-8	C-C motif chemokine ligand 20	Homo sapiens	34-39
23850670-5	2013	Poly I:C synergistically enhanced CCL20 expression from IL-1beta-stimulated HGFs.	Poly I-C	0-8	interleukin 1 beta	Homo sapiens	56-64
23382131-3	2013	Here, we show the role of IFITM3 in long-lasting neuronal impairments in mice following polyriboinosinic-polyribocytidylic acid (polyI:C, a synthetic double-stranded RNA)-induced immune challenge during the early stages of development.	Poly I-C	88-127	interferon induced transmembrane protein 3	Mus musculus	26-32
22835616-0	2013	Simvastatin suppresses RANTES-mediated neutrophilia in polyinosinic-polycytidylic acid-induced pneumonia.	Poly I-C	55-86	chemokine (C-C motif) ligand 5	Mus musculus	23-29
22835616-3	2013	In this study, we hypothesised that simvastatin inhibits polyinosinic-polycytidylic acid (poly I:C)-induced airway inflammation, such as RANTES (regulated on activation, normal T-cell expressed and secreted) expression and inflammatory cell recruitment.	Poly I-C	90-98	chemokine (C-C motif) ligand 5	Mus musculus	137-143
22835616-4	2013	In bronchial cells, the effect of simvastatin on poly I:C-induced RANTES expression and signal transducer and activator of transcription (STAT)3-mediated signal transduction was determined using an ELISA and short hairpin (sh)RNA system.	Poly I-C	49-57	chemokine (C-C motif) ligand 5	Mus musculus	66-72
22835616-6	2013	In poly I:C-stimulated bronchial cells, RANTES secretion was increased by STAT3 activation, and simvastatin suppressed poly I:C-induced STAT3 activation, resulting in inhibition of RANTES expression.	Poly I-C	3-11	chemokine (C-C motif) ligand 5	Mus musculus	40-46
22835616-6	2013	In poly I:C-stimulated bronchial cells, RANTES secretion was increased by STAT3 activation, and simvastatin suppressed poly I:C-induced STAT3 activation, resulting in inhibition of RANTES expression.	Poly I-C	3-11	signal transducer and activator of transcription 3	Mus musculus	74-79
22835616-6	2013	In poly I:C-stimulated bronchial cells, RANTES secretion was increased by STAT3 activation, and simvastatin suppressed poly I:C-induced STAT3 activation, resulting in inhibition of RANTES expression.	Poly I-C	3-11	chemokine (C-C motif) ligand 5	Mus musculus	181-187
22835616-6	2013	In poly I:C-stimulated bronchial cells, RANTES secretion was increased by STAT3 activation, and simvastatin suppressed poly I:C-induced STAT3 activation, resulting in inhibition of RANTES expression.	Poly I-C	119-127	signal transducer and activator of transcription 3	Mus musculus	136-141
22835616-6	2013	In poly I:C-stimulated bronchial cells, RANTES secretion was increased by STAT3 activation, and simvastatin suppressed poly I:C-induced STAT3 activation, resulting in inhibition of RANTES expression.	Poly I-C	119-127	chemokine (C-C motif) ligand 5	Mus musculus	181-187
23382131-8	2013	Furthermore, decreases of MAP2 expression, spine density, and dendrite complexity in the frontal cortex as well as memory impairment were evident in polyI:C-treated wild-type mice, but such neuronal impairments were not observed in ifitm3(-) (/) (-) mice.	Poly I-C	149-156	microtubule-associated protein 2	Mus musculus	26-30
23382131-9	2013	We also found that IFITM3 proteins were localized to the early endosomes of astrocytes following polyI:C treatment and reduced endocytic activity.	Poly I-C	97-104	interferon induced transmembrane protein 3	Mus musculus	19-25
23382131-3	2013	Here, we show the role of IFITM3 in long-lasting neuronal impairments in mice following polyriboinosinic-polyribocytidylic acid (polyI:C, a synthetic double-stranded RNA)-induced immune challenge during the early stages of development.	Poly I-C	129-136	interferon induced transmembrane protein 3	Mus musculus	26-32
23382131-4	2013	We found that the induction of IFITM3 expression in the brain of mice treated with polyI:C was observed only in astrocytes.	Poly I-C	83-90	interferon induced transmembrane protein 3	Mus musculus	31-37
23382131-5	2013	Cultured astrocytes were activated by polyI:C treatment, leading to an increase in the mRNA levels of inflammatory cytokines as well as Ifitm3.	Poly I-C	38-45	interferon induced transmembrane protein 3	Mus musculus	136-142
23637159-3	2013	In the present study we sought to investigate interactions between two distinct point mutations in the mouse Disc1 gene (L100P and Q31L) and maternal immune activation (MIA) during pregnancy with polyinosinic:polycytidylic acid (polyI:C).	Poly I-C	196-227	disrupted in schizophrenia 1	Mus musculus	109-114
22990623-5	2013	Poly I:C induced increased numbers of neutrophils and natural killer cells in the airways, which were blocked by CXCR2 and CCR5 antagonists, respectively.	Poly I-C	0-8	C-X-C motif chemokine receptor 2	Homo sapiens	113-118
22990623-5	2013	Poly I:C induced increased numbers of neutrophils and natural killer cells in the airways, which were blocked by CXCR2 and CCR5 antagonists, respectively.	Poly I-C	0-8	C-C motif chemokine receptor 5	Homo sapiens	123-127
23637159-4	2013	PolyI:C given at 5 mg/kg impaired cognitive and social behavior in both wild-type (WT) and Disc1-Q31L(+/-) offspring, and reduced prepulse inhibition at 16 but not 8 weeks of age.	Poly I-C	0-7	disrupted in schizophrenia 1	Mus musculus	91-96
23637159-6	2013	Interleukin-6 (IL-6) is a critical cytokine for mediating the behavioral and transcriptional effects of polyI:C.	Poly I-C	104-111	interleukin 6	Mus musculus	0-13
23637159-6	2013	Interleukin-6 (IL-6) is a critical cytokine for mediating the behavioral and transcriptional effects of polyI:C.	Poly I-C	104-111	interleukin 6	Mus musculus	15-19
23637159-7	2013	We found a more pronounced increase of IL-6 in response to polyI:C in fetal brain in Disc1-L100P(+/-) mice compared with WT or Disc1-Q31L(+/-) mice.	Poly I-C	59-66	interleukin 6	Mus musculus	39-43
23637159-7	2013	We found a more pronounced increase of IL-6 in response to polyI:C in fetal brain in Disc1-L100P(+/-) mice compared with WT or Disc1-Q31L(+/-) mice.	Poly I-C	59-66	disrupted in schizophrenia 1	Mus musculus	85-90
23637159-8	2013	Coadministration of an anti-IL-6 antibody with polyI:C reversed schizophrenia-related behavioral phenotypes in Disc1-L100P(+/-) mice.	Poly I-C	47-54	interleukin 6	Mus musculus	28-32
23637159-8	2013	Coadministration of an anti-IL-6 antibody with polyI:C reversed schizophrenia-related behavioral phenotypes in Disc1-L100P(+/-) mice.	Poly I-C	47-54	disrupted in schizophrenia 1	Mus musculus	111-116
23509354-5	2013	In models of polyinosinic-polycytidylic acid administration and adenovirus infection in vivo, CD62L(+) NK cell frequency and absolute numbers in the liver rapidly and markedly increased as a result of the augmented differentiation of CD62L(-) to CD62L(+) NK cells and recruitment of peripheral mature NK cells to the liver.	Poly I-C	13-44	selectin, lymphocyte	Mus musculus	94-99
23631691-9	2013	Furthermore, TNF-alpha and IL-1beta secretion in PAMs from group LP was statistically greater than those from the control group after stimulation with either poly(I:C) or CL097.	Poly I-C	158-167	tumor necrosis factor	Homo sapiens	13-22
23631691-9	2013	Furthermore, TNF-alpha and IL-1beta secretion in PAMs from group LP was statistically greater than those from the control group after stimulation with either poly(I:C) or CL097.	Poly I-C	158-167	interleukin 1 beta	Homo sapiens	27-35
23601685-0	2013	Poly IC triggers a cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis.	Poly I-C	0-7	cathepsin D	Homo sapiens	19-30
23601685-0	2013	Poly IC triggers a cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis.	Poly I-C	0-7	mitochondrial antiviral signaling protein	Homo sapiens	36-41
23601685-4	2013	Upon poly IC stimulation, cathepsin D was released into the cytoplasm from the lysosome to interact with IPS-1, an adaptor molecule for RLRs.	Poly I-C	5-12	cathepsin D	Homo sapiens	26-37
23601685-4	2013	Upon poly IC stimulation, cathepsin D was released into the cytoplasm from the lysosome to interact with IPS-1, an adaptor molecule for RLRs.	Poly I-C	5-12	mitochondrial antiviral signaling protein	Homo sapiens	105-110
23454169-6	2013	KEY FINDINGS: PEITC suppressed the activation of IRF3 and the expression of IP-10 induced by lipopolysaccharide (LPS) or polyinosinic-polycytidylic acid (poly[I:C]).	Poly I-C	121-152	interferon regulatory factor 3	Mus musculus	49-53
23454169-6	2013	KEY FINDINGS: PEITC suppressed the activation of IRF3 and the expression of IP-10 induced by lipopolysaccharide (LPS) or polyinosinic-polycytidylic acid (poly[I:C]).	Poly I-C	121-152	chemokine (C-X-C motif) ligand 10	Mus musculus	76-81
23509354-5	2013	In models of polyinosinic-polycytidylic acid administration and adenovirus infection in vivo, CD62L(+) NK cell frequency and absolute numbers in the liver rapidly and markedly increased as a result of the augmented differentiation of CD62L(-) to CD62L(+) NK cells and recruitment of peripheral mature NK cells to the liver.	Poly I-C	13-44	selectin, lymphocyte	Mus musculus	234-239
23509354-5	2013	In models of polyinosinic-polycytidylic acid administration and adenovirus infection in vivo, CD62L(+) NK cell frequency and absolute numbers in the liver rapidly and markedly increased as a result of the augmented differentiation of CD62L(-) to CD62L(+) NK cells and recruitment of peripheral mature NK cells to the liver.	Poly I-C	13-44	selectin, lymphocyte	Mus musculus	234-239
23428672-6	2013	When miR-155 expression was specifically blocked, cellular IFN expression and the induction of IFN by poly I:C treatment were suppressed.	Poly I-C	102-110	microRNA 155	Homo sapiens	5-12
23401273-3	2013	Human brain microvascular ECs expressed functional toll-like receptor 3 (TLR3) that could be activated by polyinosinic-polycytidylic acid (PolyI:C), resulting in the induction of endogenous interferon-beta (IFN-beta) and IFN-lambda.	Poly I-C	106-137	toll like receptor 3	Homo sapiens	51-71
23401273-3	2013	Human brain microvascular ECs expressed functional toll-like receptor 3 (TLR3) that could be activated by polyinosinic-polycytidylic acid (PolyI:C), resulting in the induction of endogenous interferon-beta (IFN-beta) and IFN-lambda.	Poly I-C	106-137	toll like receptor 3	Homo sapiens	73-77
23401273-3	2013	Human brain microvascular ECs expressed functional toll-like receptor 3 (TLR3) that could be activated by polyinosinic-polycytidylic acid (PolyI:C), resulting in the induction of endogenous interferon-beta (IFN-beta) and IFN-lambda.	Poly I-C	106-137	interferon beta 1	Homo sapiens	190-205
23401273-3	2013	Human brain microvascular ECs expressed functional toll-like receptor 3 (TLR3) that could be activated by polyinosinic-polycytidylic acid (PolyI:C), resulting in the induction of endogenous interferon-beta (IFN-beta) and IFN-lambda.	Poly I-C	106-137	interferon beta 1	Homo sapiens	207-215
23401273-3	2013	Human brain microvascular ECs expressed functional toll-like receptor 3 (TLR3) that could be activated by polyinosinic-polycytidylic acid (PolyI:C), resulting in the induction of endogenous interferon-beta (IFN-beta) and IFN-lambda.	Poly I-C	139-146	toll like receptor 3	Homo sapiens	51-71
23401273-3	2013	Human brain microvascular ECs expressed functional toll-like receptor 3 (TLR3) that could be activated by polyinosinic-polycytidylic acid (PolyI:C), resulting in the induction of endogenous interferon-beta (IFN-beta) and IFN-lambda.	Poly I-C	139-146	toll like receptor 3	Homo sapiens	73-77
23401273-3	2013	Human brain microvascular ECs expressed functional toll-like receptor 3 (TLR3) that could be activated by polyinosinic-polycytidylic acid (PolyI:C), resulting in the induction of endogenous interferon-beta (IFN-beta) and IFN-lambda.	Poly I-C	139-146	interferon beta 1	Homo sapiens	190-205
23401273-3	2013	Human brain microvascular ECs expressed functional toll-like receptor 3 (TLR3) that could be activated by polyinosinic-polycytidylic acid (PolyI:C), resulting in the induction of endogenous interferon-beta (IFN-beta) and IFN-lambda.	Poly I-C	139-146	interferon beta 1	Homo sapiens	207-215
23577829-9	2013	In addition, HDAC inhibitors significantly inhibited poly (I:C)-induced IL-6 production in both of the epithelial cells.	Poly I-C	53-63	interleukin 6	Homo sapiens	72-76
23428672-6	2013	When miR-155 expression was specifically blocked, cellular IFN expression and the induction of IFN by poly I:C treatment were suppressed.	Poly I-C	102-110	interferon alpha 1	Homo sapiens	95-98
23386607-5	2013	The presence of poly(I:C) increased the accumulation of LL-37 in Rab5 endosomes.	Poly I-C	16-25	cathelicidin antimicrobial peptide	Homo sapiens	56-61
23352460-9	2013	Poly(I:C) and CpG-oligonucleotide promoted the immunosuppressive potentiality of UC-MSCs, accompanied with the phosphorylation of interferon regulatory factor 3 (IRF3) and increased expression of indoleamine 2,3-dioxygenase and interferon beta, whereas activation of other TLR ligands (synthetic analog fibroblast-stimulating lipopeptide-1 and lipopolysaccharide) failed to affect the immunoregulatory activity of UC-MSCs.	Poly I-C	0-8	interferon regulatory factor 3	Homo sapiens	130-160
23352460-9	2013	Poly(I:C) and CpG-oligonucleotide promoted the immunosuppressive potentiality of UC-MSCs, accompanied with the phosphorylation of interferon regulatory factor 3 (IRF3) and increased expression of indoleamine 2,3-dioxygenase and interferon beta, whereas activation of other TLR ligands (synthetic analog fibroblast-stimulating lipopeptide-1 and lipopolysaccharide) failed to affect the immunoregulatory activity of UC-MSCs.	Poly I-C	0-8	interferon regulatory factor 3	Homo sapiens	162-166
23352460-9	2013	Poly(I:C) and CpG-oligonucleotide promoted the immunosuppressive potentiality of UC-MSCs, accompanied with the phosphorylation of interferon regulatory factor 3 (IRF3) and increased expression of indoleamine 2,3-dioxygenase and interferon beta, whereas activation of other TLR ligands (synthetic analog fibroblast-stimulating lipopeptide-1 and lipopolysaccharide) failed to affect the immunoregulatory activity of UC-MSCs.	Poly I-C	0-8	interferon beta 1	Homo sapiens	228-243
23271706-2	2013	poly I:C, a synthetic analog of viral dsRNA and a TLR3 agonist, is studied extensively as vaccine adjuvant as a result of its pleotropic immune-stimulatory effects.	Poly I-C	0-8	toll-like receptor 3	Mus musculus	50-54
23497334-11	2013	Compared to AMo of never-smokers, poly(I:C)-stimulated production of CXCL10 was significantly reduced in AMo of smokers.	Poly I-C	34-43	C-X-C motif chemokine ligand 10	Homo sapiens	69-75
23271706-3	2013	Here, we show that systemic poly I:C administration induces substantial IL-7 production in the lung in a type 1 IFN- and IFN-gamma-dependent fashion.	Poly I-C	28-36	interleukin 7	Mus musculus	72-76
23271706-3	2013	Here, we show that systemic poly I:C administration induces substantial IL-7 production in the lung in a type 1 IFN- and IFN-gamma-dependent fashion.	Poly I-C	28-36	interferon gamma	Mus musculus	105-130
23271706-6	2013	We also show that the initial up-regulation of CXCR3 ligands and infiltration of T cells in the lung are mediated by poly I:C-induced IFN-gamma from NK cells; however, the sustained and optimal CXCR3 ligand expression and T cell infiltration require poly I:C-induced IL-7 and T cell-derived IFN-gamma.	Poly I-C	117-125	chemokine (C-X-C motif) receptor 3	Mus musculus	47-52
23271706-6	2013	We also show that the initial up-regulation of CXCR3 ligands and infiltration of T cells in the lung are mediated by poly I:C-induced IFN-gamma from NK cells; however, the sustained and optimal CXCR3 ligand expression and T cell infiltration require poly I:C-induced IL-7 and T cell-derived IFN-gamma.	Poly I-C	117-125	interferon gamma	Mus musculus	134-143
23271706-6	2013	We also show that the initial up-regulation of CXCR3 ligands and infiltration of T cells in the lung are mediated by poly I:C-induced IFN-gamma from NK cells; however, the sustained and optimal CXCR3 ligand expression and T cell infiltration require poly I:C-induced IL-7 and T cell-derived IFN-gamma.	Poly I-C	117-125	chemokine (C-X-C motif) receptor 3	Mus musculus	194-199
23271706-6	2013	We also show that the initial up-regulation of CXCR3 ligands and infiltration of T cells in the lung are mediated by poly I:C-induced IFN-gamma from NK cells; however, the sustained and optimal CXCR3 ligand expression and T cell infiltration require poly I:C-induced IL-7 and T cell-derived IFN-gamma.	Poly I-C	117-125	interleukin 7	Mus musculus	267-271
23271706-6	2013	We also show that the initial up-regulation of CXCR3 ligands and infiltration of T cells in the lung are mediated by poly I:C-induced IFN-gamma from NK cells; however, the sustained and optimal CXCR3 ligand expression and T cell infiltration require poly I:C-induced IL-7 and T cell-derived IFN-gamma.	Poly I-C	117-125	interferon gamma	Mus musculus	291-300
23271706-6	2013	We also show that the initial up-regulation of CXCR3 ligands and infiltration of T cells in the lung are mediated by poly I:C-induced IFN-gamma from NK cells; however, the sustained and optimal CXCR3 ligand expression and T cell infiltration require poly I:C-induced IL-7 and T cell-derived IFN-gamma.	Poly I-C	250-258	chemokine (C-X-C motif) receptor 3	Mus musculus	47-52
23271706-6	2013	We also show that the initial up-regulation of CXCR3 ligands and infiltration of T cells in the lung are mediated by poly I:C-induced IFN-gamma from NK cells; however, the sustained and optimal CXCR3 ligand expression and T cell infiltration require poly I:C-induced IL-7 and T cell-derived IFN-gamma.	Poly I-C	250-258	chemokine (C-X-C motif) receptor 3	Mus musculus	194-199
23271706-7	2013	In a model of multiorgan inflammation elicited by adoptive transfer of immune cells into RAG1(-/-) mice, we show that poly I:C enhances IL-7 production in the lung and promotes expression of CXCR3 ligands and recruitment of IFN-gamma(+) T cells in an IL-7-dependent fashion.	Poly I-C	118-126	recombination activating 1	Mus musculus	89-93
23271706-7	2013	In a model of multiorgan inflammation elicited by adoptive transfer of immune cells into RAG1(-/-) mice, we show that poly I:C enhances IL-7 production in the lung and promotes expression of CXCR3 ligands and recruitment of IFN-gamma(+) T cells in an IL-7-dependent fashion.	Poly I-C	118-126	interleukin 7	Mus musculus	136-140
23271706-7	2013	In a model of multiorgan inflammation elicited by adoptive transfer of immune cells into RAG1(-/-) mice, we show that poly I:C enhances IL-7 production in the lung and promotes expression of CXCR3 ligands and recruitment of IFN-gamma(+) T cells in an IL-7-dependent fashion.	Poly I-C	118-126	chemokine (C-X-C motif) receptor 3	Mus musculus	191-196
23271706-7	2013	In a model of multiorgan inflammation elicited by adoptive transfer of immune cells into RAG1(-/-) mice, we show that poly I:C enhances IL-7 production in the lung and promotes expression of CXCR3 ligands and recruitment of IFN-gamma(+) T cells in an IL-7-dependent fashion.	Poly I-C	118-126	interferon gamma	Mus musculus	224-233
23271706-7	2013	In a model of multiorgan inflammation elicited by adoptive transfer of immune cells into RAG1(-/-) mice, we show that poly I:C enhances IL-7 production in the lung and promotes expression of CXCR3 ligands and recruitment of IFN-gamma(+) T cells in an IL-7-dependent fashion.	Poly I-C	118-126	interleukin 7	Mus musculus	251-255
23271706-8	2013	Collectively, these results strongly support our hypothesis and delineate a new mechanism by which poly I:C boosts the T cell immune response in the lung by inducing local IL-7 production, which in turn, enhances T cell-derived IFN-gamma to promote macrophage recruitment, CXCR3 ligand expression, and T cell infiltration.	Poly I-C	99-107	interleukin 7	Mus musculus	172-176
23271706-8	2013	Collectively, these results strongly support our hypothesis and delineate a new mechanism by which poly I:C boosts the T cell immune response in the lung by inducing local IL-7 production, which in turn, enhances T cell-derived IFN-gamma to promote macrophage recruitment, CXCR3 ligand expression, and T cell infiltration.	Poly I-C	99-107	interferon gamma	Mus musculus	228-237
23271706-8	2013	Collectively, these results strongly support our hypothesis and delineate a new mechanism by which poly I:C boosts the T cell immune response in the lung by inducing local IL-7 production, which in turn, enhances T cell-derived IFN-gamma to promote macrophage recruitment, CXCR3 ligand expression, and T cell infiltration.	Poly I-C	99-107	chemokine (C-X-C motif) receptor 3	Mus musculus	273-278
23392170-7	2013	Expectedly, exogenous miR-145 decreased the expression level of SOCS7, and socs7-silencing enhanced IFN-beta induction by transfection with a TLR3 ligand, polyinosinic acid-polycytidylic acid (PIC).	Poly I-C	155-191	suppressor of cytokine signaling 7	Homo sapiens	75-80
23392170-7	2013	Expectedly, exogenous miR-145 decreased the expression level of SOCS7, and socs7-silencing enhanced IFN-beta induction by transfection with a TLR3 ligand, polyinosinic acid-polycytidylic acid (PIC).	Poly I-C	155-191	interferon beta 1	Homo sapiens	100-108
23201589-0	2013	Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression.	Poly I-C	0-8	brain-derived neurotrophic factor	Rattus norvegicus	151-155
23201589-2	2013	Furthermore, the ability of poly I:C to deplete central tryptophan and serotonin via induction of indolamine 2,3 dioxygenase (IDO), and also the ability of poly I:C to impact upon expression of the neurotrophin BDNF and its receptor TrkB were examined as potential mechanisms to link inflammation to depression.	Poly I-C	28-36	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	98-124
23201589-2	2013	Furthermore, the ability of poly I:C to deplete central tryptophan and serotonin via induction of indolamine 2,3 dioxygenase (IDO), and also the ability of poly I:C to impact upon expression of the neurotrophin BDNF and its receptor TrkB were examined as potential mechanisms to link inflammation to depression.	Poly I-C	156-164	brain-derived neurotrophic factor	Rattus norvegicus	211-215
23201589-2	2013	Furthermore, the ability of poly I:C to deplete central tryptophan and serotonin via induction of indolamine 2,3 dioxygenase (IDO), and also the ability of poly I:C to impact upon expression of the neurotrophin BDNF and its receptor TrkB were examined as potential mechanisms to link inflammation to depression.	Poly I-C	28-36	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	126-129
23201589-2	2013	Furthermore, the ability of poly I:C to deplete central tryptophan and serotonin via induction of indolamine 2,3 dioxygenase (IDO), and also the ability of poly I:C to impact upon expression of the neurotrophin BDNF and its receptor TrkB were examined as potential mechanisms to link inflammation to depression.	Poly I-C	156-164	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	233-237
23201589-3	2013	Poly I:C induced a neuroinflammatory response characterised by increased expression of IL-1beta, IL-6, TNF-alpha and CD11b in frontal cortex and hippocampus.	Poly I-C	0-8	interleukin 1 beta	Rattus norvegicus	87-95
23201589-3	2013	Poly I:C induced a neuroinflammatory response characterised by increased expression of IL-1beta, IL-6, TNF-alpha and CD11b in frontal cortex and hippocampus.	Poly I-C	0-8	interleukin 6	Rattus norvegicus	97-101
23201589-3	2013	Poly I:C induced a neuroinflammatory response characterised by increased expression of IL-1beta, IL-6, TNF-alpha and CD11b in frontal cortex and hippocampus.	Poly I-C	0-8	tumor necrosis factor	Rattus norvegicus	103-112
22868899-1	2013	Although polyinosinic-polycytidylic acid (poly(I:C)) has been applied in tumor immunity as a Toll-like receptor 3 (TLR3) ligand, the interaction between poly(I:C) and TLR3 is still unclear, as are the mechanisms underlying the antitumor effect of poly(I:C).	Poly I-C	9-40	toll like receptor 3	Homo sapiens	93-113
23201589-2	2013	Furthermore, the ability of poly I:C to deplete central tryptophan and serotonin via induction of indolamine 2,3 dioxygenase (IDO), and also the ability of poly I:C to impact upon expression of the neurotrophin BDNF and its receptor TrkB were examined as potential mechanisms to link inflammation to depression.	Poly I-C	28-36	brain-derived neurotrophic factor	Rattus norvegicus	211-215
23201589-3	2013	Poly I:C induced a neuroinflammatory response characterised by increased expression of IL-1beta, IL-6, TNF-alpha and CD11b in frontal cortex and hippocampus.	Poly I-C	0-8	integrin subunit alpha M	Rattus norvegicus	117-122
23201589-2	2013	Furthermore, the ability of poly I:C to deplete central tryptophan and serotonin via induction of indolamine 2,3 dioxygenase (IDO), and also the ability of poly I:C to impact upon expression of the neurotrophin BDNF and its receptor TrkB were examined as potential mechanisms to link inflammation to depression.	Poly I-C	28-36	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	233-237
23201589-8	2013	In addition, poly I:C increased central IDO expression and increased concentrations of tryptophan, and its metabolite kynurenine.	Poly I-C	13-21	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	40-43
22749216-5	2013	Simultaneous treatment of cells with DNA and dsRNA analog poly(I:C) leads to inhibition of poly(I:C)-activated secretion of IL-6 and IL-8.	Poly I-C	58-66	interleukin 6	Homo sapiens	124-128
23201589-10	2013	These findings suggest that depressive and anxiety-like behaviours elicited by poly I:C are associated with a reduction in BDNF signalling, and activation of the kynurenine pathway, but not a reduction in serotonin.	Poly I-C	79-87	brain-derived neurotrophic factor	Rattus norvegicus	123-127
23422193-3	2013	In this study, we aimed to clarify the possible mechanism of TLR3 involved in polyinosine-polycytidylic acid (poly(I:C)) promoting excessive iodine intake induced thyroiditis in non-obese diabetic (NOD) mice.	Poly I-C	110-119	toll-like receptor 3	Mus musculus	61-65
23178261-10	2013	TGF-beta1b expression was also increased by polyinosinic:polycytidylic acid (poly(I:C)) and/or lipopolysaccharide (LPS) stimulation in three different trout cell lines studied.	Poly I-C	77-86	transforming growth factor, beta 1a	Oncorhynchus mykiss	0-10
22868899-1	2013	Although polyinosinic-polycytidylic acid (poly(I:C)) has been applied in tumor immunity as a Toll-like receptor 3 (TLR3) ligand, the interaction between poly(I:C) and TLR3 is still unclear, as are the mechanisms underlying the antitumor effect of poly(I:C).	Poly I-C	9-40	toll like receptor 3	Homo sapiens	115-119
22749216-5	2013	Simultaneous treatment of cells with DNA and dsRNA analog poly(I:C) leads to inhibition of poly(I:C)-activated secretion of IL-6 and IL-8.	Poly I-C	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
22749216-5	2013	Simultaneous treatment of cells with DNA and dsRNA analog poly(I:C) leads to inhibition of poly(I:C)-activated secretion of IL-6 and IL-8.	Poly I-C	58-67	interleukin 6	Homo sapiens	124-128
22749216-5	2013	Simultaneous treatment of cells with DNA and dsRNA analog poly(I:C) leads to inhibition of poly(I:C)-activated secretion of IL-6 and IL-8.	Poly I-C	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
23162109-9	2013	Further study revealed that stimulation with poly(I:C) (a synthetic analogue of viral dsRNA) increased the expression of CX3CL1 on cultured BECs followed by increased migrational activity of cultured NK cells.	Poly I-C	45-54	C-X3-C motif chemokine ligand 1	Homo sapiens	121-127
22732733-6	2013	The TfPLL conjugate protected TLR3 ligand polyinosinic:polycytidylic acid [poly(I:C)] from RNase degradation and enhanced the uptake of poly(I:C) in HeLa cells.	Poly I-C	75-84	toll like receptor 3	Homo sapiens	30-34
22732733-8	2013	Time dependence of the production of IL-6 in the primary cell line showed that TfPLL conjugate enabled a gradual release of poly(I:C) and stronger activation of TLR3 receptor in comparison with poly(I:C) alone.	Poly I-C	124-132	interleukin 6	Homo sapiens	37-41
23015382-4	2013	Pretreatment of the cells with propolis inhibited poly I:C (synthetic dsRNA)-induced interferon (IFN)-beta expression.	Poly I-C	50-58	interferon beta 1	Homo sapiens	85-106
22685032-10	2013	CXCL10 was secreted from the colonic epithelial cell lines in response to the Toll-like receptor 3 (TLR3) ligand polyinosinic: polycytidylic acid (poly(I:C)).	Poly I-C	113-145	C-X-C motif chemokine ligand 10	Homo sapiens	0-6
22685032-10	2013	CXCL10 was secreted from the colonic epithelial cell lines in response to the Toll-like receptor 3 (TLR3) ligand polyinosinic: polycytidylic acid (poly(I:C)).	Poly I-C	113-145	toll like receptor 3	Homo sapiens	78-98
22685032-10	2013	CXCL10 was secreted from the colonic epithelial cell lines in response to the Toll-like receptor 3 (TLR3) ligand polyinosinic: polycytidylic acid (poly(I:C)).	Poly I-C	113-145	toll like receptor 3	Homo sapiens	100-104
22984986-5	2013	RESULTS: EC from all FRT compartments constitutively expressed NOD1, NOD2, RIG-1, and MDA5 with highest levels expressed by FT. Stimulation with poly(I:C) resulted in upregulation of NOD2, RIG-1, and MDA5 in all FRT compartments and correlated with increased secretion of IL-8, whereas estradiol treatment had no effects.	Poly I-C	145-153	nucleotide binding oligomerization domain containing 1	Homo sapiens	63-67
23023014-5	2013	To activate TLR3, polyinosinic-polycytidylic acid (poly I:C) was injected into mice.	Poly I-C	18-49	toll-like receptor 3	Mus musculus	12-16
23023014-5	2013	To activate TLR3, polyinosinic-polycytidylic acid (poly I:C) was injected into mice.	Poly I-C	51-59	toll-like receptor 3	Mus musculus	12-16
23023014-8	2013	In addition, freshly isolated HSCs and Kupffer cells from poly I:C-treated mice showed enhanced expression of IL-10 compared to controls.	Poly I-C	58-66	interleukin 10	Mus musculus	110-115
23023014-9	2013	Infiltrated macrophage numbers and the expression of tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and IL-6 on these cells were decreased after poly I:C treatment.	Poly I-C	162-170	tumor necrosis factor	Mus musculus	53-80
23023014-9	2013	Infiltrated macrophage numbers and the expression of tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and IL-6 on these cells were decreased after poly I:C treatment.	Poly I-C	162-170	chemokine (C-C motif) ligand 2	Mus musculus	82-116
23023014-9	2013	Infiltrated macrophage numbers and the expression of tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and IL-6 on these cells were decreased after poly I:C treatment.	Poly I-C	162-170	interleukin 6	Mus musculus	121-125
23023014-10	2013	In vitro, poly I:C treatment enhanced the expression of IL-10 via a TLR3-dependent mechanism in HSCs and Kupffer cells.	Poly I-C	10-18	interleukin 10	Mus musculus	56-61
23023014-10	2013	In vitro, poly I:C treatment enhanced the expression of IL-10 via a TLR3-dependent mechanism in HSCs and Kupffer cells.	Poly I-C	10-18	toll-like receptor 3	Mus musculus	68-72
23023014-11	2013	Finally, the protective effects of poly I:C on alcoholic liver injury were diminished in TLR3(-/-) and IL-10(-/-) mice.	Poly I-C	35-43	toll-like receptor 3	Mus musculus	89-93
23023014-11	2013	Finally, the protective effects of poly I:C on alcoholic liver injury were diminished in TLR3(-/-) and IL-10(-/-) mice.	Poly I-C	35-43	interleukin 10	Mus musculus	103-108
22457005-9	2013	Furthermore, poly (I:C)-induced caspase 3 cleavage in SGECs was also inhibited by LY294002.	Poly I-C	13-23	caspase 3	Homo sapiens	32-41
22989785-4	2013	We therefore investigated if the viral RNA substitute polyinosine-polycytidylic acid (poly (I:C)) could influence the cytokine induced production of CXCL10 by adrenocortical cells.	Poly I-C	86-96	C-X-C motif chemokine ligand 10	Homo sapiens	149-155
22989785-5	2013	We found that poly (I:C) could induce CXCL10 in NCI-H295R adrenocortical carcinoma cells, either alone or synergistically along with cytokines interferon-gamma and tumor necrosis factor-alpha.	Poly I-C	14-24	C-X-C motif chemokine ligand 10	Homo sapiens	38-44
22989785-5	2013	We found that poly (I:C) could induce CXCL10 in NCI-H295R adrenocortical carcinoma cells, either alone or synergistically along with cytokines interferon-gamma and tumor necrosis factor-alpha.	Poly I-C	14-24	interferon gamma	Homo sapiens	143-191
22984986-5	2013	RESULTS: EC from all FRT compartments constitutively expressed NOD1, NOD2, RIG-1, and MDA5 with highest levels expressed by FT. Stimulation with poly(I:C) resulted in upregulation of NOD2, RIG-1, and MDA5 in all FRT compartments and correlated with increased secretion of IL-8, whereas estradiol treatment had no effects.	Poly I-C	145-153	nucleotide binding oligomerization domain containing 2	Homo sapiens	69-73
22984986-5	2013	RESULTS: EC from all FRT compartments constitutively expressed NOD1, NOD2, RIG-1, and MDA5 with highest levels expressed by FT. Stimulation with poly(I:C) resulted in upregulation of NOD2, RIG-1, and MDA5 in all FRT compartments and correlated with increased secretion of IL-8, whereas estradiol treatment had no effects.	Poly I-C	145-153	phospholipase A and acyltransferase 4	Homo sapiens	75-80
22984986-5	2013	RESULTS: EC from all FRT compartments constitutively expressed NOD1, NOD2, RIG-1, and MDA5 with highest levels expressed by FT. Stimulation with poly(I:C) resulted in upregulation of NOD2, RIG-1, and MDA5 in all FRT compartments and correlated with increased secretion of IL-8, whereas estradiol treatment had no effects.	Poly I-C	145-153	interferon induced with helicase C domain 1	Homo sapiens	86-90
22984986-5	2013	RESULTS: EC from all FRT compartments constitutively expressed NOD1, NOD2, RIG-1, and MDA5 with highest levels expressed by FT. Stimulation with poly(I:C) resulted in upregulation of NOD2, RIG-1, and MDA5 in all FRT compartments and correlated with increased secretion of IL-8, whereas estradiol treatment had no effects.	Poly I-C	145-153	nucleotide binding oligomerization domain containing 2	Homo sapiens	183-187
22984986-5	2013	RESULTS: EC from all FRT compartments constitutively expressed NOD1, NOD2, RIG-1, and MDA5 with highest levels expressed by FT. Stimulation with poly(I:C) resulted in upregulation of NOD2, RIG-1, and MDA5 in all FRT compartments and correlated with increased secretion of IL-8, whereas estradiol treatment had no effects.	Poly I-C	145-153	phospholipase A and acyltransferase 4	Homo sapiens	189-194
22984986-5	2013	RESULTS: EC from all FRT compartments constitutively expressed NOD1, NOD2, RIG-1, and MDA5 with highest levels expressed by FT. Stimulation with poly(I:C) resulted in upregulation of NOD2, RIG-1, and MDA5 in all FRT compartments and correlated with increased secretion of IL-8, whereas estradiol treatment had no effects.	Poly I-C	145-153	interferon induced with helicase C domain 1	Homo sapiens	200-204
22984986-5	2013	RESULTS: EC from all FRT compartments constitutively expressed NOD1, NOD2, RIG-1, and MDA5 with highest levels expressed by FT. Stimulation with poly(I:C) resulted in upregulation of NOD2, RIG-1, and MDA5 in all FRT compartments and correlated with increased secretion of IL-8, whereas estradiol treatment had no effects.	Poly I-C	145-153	C-X-C motif chemokine ligand 8	Homo sapiens	272-276
22954322-7	2013	Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor.	Poly I-C	12-21	interleukin 6	Homo sapiens	43-47
23036922-4	2013	PolyI:C injection during the peripubertal period markedly increased expression of interferon-stimulated genes (Ifit2, Prkr, Mx2 and Irf7) in the hippocampal dentate gyrus demonstrating that peripheral administration of the viral mimic in the adolescent animal does have direct effects in the brain.	Poly I-C	0-7	interferon-induced protein with tetratricopeptide repeats 2	Rattus norvegicus	111-116
23036922-4	2013	PolyI:C injection during the peripubertal period markedly increased expression of interferon-stimulated genes (Ifit2, Prkr, Mx2 and Irf7) in the hippocampal dentate gyrus demonstrating that peripheral administration of the viral mimic in the adolescent animal does have direct effects in the brain.	Poly I-C	0-7	eukaryotic translation initiation factor 2-alpha kinase 2	Rattus norvegicus	118-122
23036922-4	2013	PolyI:C injection during the peripubertal period markedly increased expression of interferon-stimulated genes (Ifit2, Prkr, Mx2 and Irf7) in the hippocampal dentate gyrus demonstrating that peripheral administration of the viral mimic in the adolescent animal does have direct effects in the brain.	Poly I-C	0-7	MX dynamin like GTPase 2	Rattus norvegicus	124-127
23036922-4	2013	PolyI:C injection during the peripubertal period markedly increased expression of interferon-stimulated genes (Ifit2, Prkr, Mx2 and Irf7) in the hippocampal dentate gyrus demonstrating that peripheral administration of the viral mimic in the adolescent animal does have direct effects in the brain.	Poly I-C	0-7	interferon regulatory factor 7	Rattus norvegicus	132-136
23051007-5	2013	Both poly I:C and LPS stimulation in porcine islets induced expression of chemokines (RANTES, MCP-1, IP-10, and IL-8), cytokines (IL-6 and type I interferons), and adhesion molecules (VCAM-1 and ICAM-1).	Poly I-C	5-13	chemokine (C-C motif) ligand 5	Mus musculus	86-92
23051007-5	2013	Both poly I:C and LPS stimulation in porcine islets induced expression of chemokines (RANTES, MCP-1, IP-10, and IL-8), cytokines (IL-6 and type I interferons), and adhesion molecules (VCAM-1 and ICAM-1).	Poly I-C	5-13	mast cell protease 1	Mus musculus	94-99
23051007-5	2013	Both poly I:C and LPS stimulation in porcine islets induced expression of chemokines (RANTES, MCP-1, IP-10, and IL-8), cytokines (IL-6 and type I interferons), and adhesion molecules (VCAM-1 and ICAM-1).	Poly I-C	5-13	chemokine (C-X-C motif) ligand 10	Mus musculus	101-106
23051007-5	2013	Both poly I:C and LPS stimulation in porcine islets induced expression of chemokines (RANTES, MCP-1, IP-10, and IL-8), cytokines (IL-6 and type I interferons), and adhesion molecules (VCAM-1 and ICAM-1).	Poly I-C	5-13	chemokine (C-X-C motif) ligand 15	Mus musculus	112-116
23051007-5	2013	Both poly I:C and LPS stimulation in porcine islets induced expression of chemokines (RANTES, MCP-1, IP-10, and IL-8), cytokines (IL-6 and type I interferons), and adhesion molecules (VCAM-1 and ICAM-1).	Poly I-C	5-13	interleukin 6	Mus musculus	130-134
23051007-5	2013	Both poly I:C and LPS stimulation in porcine islets induced expression of chemokines (RANTES, MCP-1, IP-10, and IL-8), cytokines (IL-6 and type I interferons), and adhesion molecules (VCAM-1 and ICAM-1).	Poly I-C	5-13	vascular cell adhesion molecule 1	Mus musculus	184-190
23051007-5	2013	Both poly I:C and LPS stimulation in porcine islets induced expression of chemokines (RANTES, MCP-1, IP-10, and IL-8), cytokines (IL-6 and type I interferons), and adhesion molecules (VCAM-1 and ICAM-1).	Poly I-C	5-13	intercellular adhesion molecule 1	Mus musculus	195-201
22366489-6	2013	Polyinosinic-polycytidylic acid (poly (I:C)) weakly induced the porcine SARM1 expression in the early stimulation.	Poly I-C	0-31	sterile alpha and TIR motif containing 1	Homo sapiens	72-77
22366489-6	2013	Polyinosinic-polycytidylic acid (poly (I:C)) weakly induced the porcine SARM1 expression in the early stimulation.	Poly I-C	33-44	sterile alpha and TIR motif containing 1	Homo sapiens	72-77
23363937-6	2013	RESULTS: Treatment of cells with polyinosinic-polycytidylic acid induced ISG56.	Poly I-C	33-64	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	73-78
22954322-7	2013	Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor.	Poly I-C	12-21	C-X-C motif chemokine ligand 10	Homo sapiens	49-54
22954322-7	2013	Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor.	Poly I-C	12-21	C-C motif chemokine ligand 5	Homo sapiens	60-66
22954322-7	2013	Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor.	Poly I-C	12-21	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	89-94
22954322-7	2013	Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor.	Poly I-C	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
22954322-7	2013	Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor.	Poly I-C	12-21	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	152-157
22954322-8	2013	CONCLUSIONS: The poly(I:C)-induced secretion of IL-6, IP-10, and RANTES from human corneal fibroblasts is mediated by both NF-kappaB and PI3K signaling pathways, whereas that of IL-8 is mediated by the NF-kappaB pathway.	Poly I-C	17-26	interleukin 6	Homo sapiens	48-52
22954322-8	2013	CONCLUSIONS: The poly(I:C)-induced secretion of IL-6, IP-10, and RANTES from human corneal fibroblasts is mediated by both NF-kappaB and PI3K signaling pathways, whereas that of IL-8 is mediated by the NF-kappaB pathway.	Poly I-C	17-26	C-X-C motif chemokine ligand 10	Homo sapiens	54-59
22954322-8	2013	CONCLUSIONS: The poly(I:C)-induced secretion of IL-6, IP-10, and RANTES from human corneal fibroblasts is mediated by both NF-kappaB and PI3K signaling pathways, whereas that of IL-8 is mediated by the NF-kappaB pathway.	Poly I-C	17-26	C-C motif chemokine ligand 5	Homo sapiens	65-71
22954322-8	2013	CONCLUSIONS: The poly(I:C)-induced secretion of IL-6, IP-10, and RANTES from human corneal fibroblasts is mediated by both NF-kappaB and PI3K signaling pathways, whereas that of IL-8 is mediated by the NF-kappaB pathway.	Poly I-C	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
23711857-9	2013	RESULTS: Alternaria and polyinosinic-polycytidylic acid (poly I:C) enhanced cell surface expression of MHC class II, CD40, CD80, CD86 and OX40L, and IL-6 production in a concentration-dependent manner.	Poly I-C	24-55	CD40 molecule	Homo sapiens	117-121
23085636-8	2013	Moreover, IFNalpha levels were higher in No than in Hy individuals at all time points, and a similar difference was seen in Mx at 48 h. In vivo stimulation with poly I:C elicited strong elevation of the IL-1beta, IFNgamma, Mx and IP10 mRNA transcripts in head kidney, while TNFalpha1 and IFNalpha were found unaffected.	Poly I-C	161-169	tumor necrosis factor alpha-1 precursor	Salmo salar	274-283
22445076-9	2013	Polyinosinic-polycytidylic acid (poly I:C), which does not signal through MyD88, also induced cell surface CD11c down-regulation.	Poly I-C	0-31	integrin alpha X	Mus musculus	107-112
23035017-1	2013	TLR3 recognizes various forms of double stranded (ds) RNA, including viral dsRNA and a synthetic mimic of dsRNA, poly I:C, which has been used extensively as a TLR3 ligand to induce antiviral immunity.	Poly I-C	113-121	toll like receptor 3	Homo sapiens	0-4
23035017-1	2013	TLR3 recognizes various forms of double stranded (ds) RNA, including viral dsRNA and a synthetic mimic of dsRNA, poly I:C, which has been used extensively as a TLR3 ligand to induce antiviral immunity.	Poly I-C	113-121	toll like receptor 3	Homo sapiens	160-164
23035017-5	2013	However, the transfection of poly I:C was necessary to induce TLR3 activation in other cell types studied.	Poly I-C	29-37	toll like receptor 3	Homo sapiens	62-66
23711857-9	2013	RESULTS: Alternaria and polyinosinic-polycytidylic acid (poly I:C) enhanced cell surface expression of MHC class II, CD40, CD80, CD86 and OX40L, and IL-6 production in a concentration-dependent manner.	Poly I-C	24-55	CD80 molecule	Homo sapiens	123-127
23711857-9	2013	RESULTS: Alternaria and polyinosinic-polycytidylic acid (poly I:C) enhanced cell surface expression of MHC class II, CD40, CD80, CD86 and OX40L, and IL-6 production in a concentration-dependent manner.	Poly I-C	24-55	CD86 molecule	Homo sapiens	129-133
23711857-9	2013	RESULTS: Alternaria and polyinosinic-polycytidylic acid (poly I:C) enhanced cell surface expression of MHC class II, CD40, CD80, CD86 and OX40L, and IL-6 production in a concentration-dependent manner.	Poly I-C	24-55	TNF superfamily member 4	Homo sapiens	138-143
23711857-9	2013	RESULTS: Alternaria and polyinosinic-polycytidylic acid (poly I:C) enhanced cell surface expression of MHC class II, CD40, CD80, CD86 and OX40L, and IL-6 production in a concentration-dependent manner.	Poly I-C	24-55	interleukin 6	Homo sapiens	149-153
23711857-9	2013	RESULTS: Alternaria and polyinosinic-polycytidylic acid (poly I:C) enhanced cell surface expression of MHC class II, CD40, CD80, CD86 and OX40L, and IL-6 production in a concentration-dependent manner.	Poly I-C	57-65	CD40 molecule	Homo sapiens	117-121
23711857-9	2013	RESULTS: Alternaria and polyinosinic-polycytidylic acid (poly I:C) enhanced cell surface expression of MHC class II, CD40, CD80, CD86 and OX40L, and IL-6 production in a concentration-dependent manner.	Poly I-C	57-65	CD80 molecule	Homo sapiens	123-127
23711857-9	2013	RESULTS: Alternaria and polyinosinic-polycytidylic acid (poly I:C) enhanced cell surface expression of MHC class II, CD40, CD80, CD86 and OX40L, and IL-6 production in a concentration-dependent manner.	Poly I-C	57-65	CD86 molecule	Homo sapiens	129-133
23711857-9	2013	RESULTS: Alternaria and polyinosinic-polycytidylic acid (poly I:C) enhanced cell surface expression of MHC class II, CD40, CD80, CD86 and OX40L, and IL-6 production in a concentration-dependent manner.	Poly I-C	57-65	TNF superfamily member 4	Homo sapiens	138-143
23711857-9	2013	RESULTS: Alternaria and polyinosinic-polycytidylic acid (poly I:C) enhanced cell surface expression of MHC class II, CD40, CD80, CD86 and OX40L, and IL-6 production in a concentration-dependent manner.	Poly I-C	57-65	interleukin 6	Homo sapiens	149-153
23781248-0	2013	Possible Involvement of Foxp3(+) Regulatory T Cells in the Development of Immune-Mediated Pancreatitis in MRL/Mp Mice Treated with Polyinosinic:Polycytidylic Acid.	Poly I-C	131-162	forkhead box P3	Mus musculus	24-29
22948082-4	2013	We have shown that an analog of viral double-stranded RNA, polyinosinic-polycytidylic acid (poly IC), upregulated the expression of B7-H1 on airway epithelial cells, an effect which was corticosteroid-resistant.	Poly I-C	59-90	CD274 antigen	Mus musculus	132-137
22948082-4	2013	We have shown that an analog of viral double-stranded RNA, polyinosinic-polycytidylic acid (poly IC), upregulated the expression of B7-H1 on airway epithelial cells, an effect which was corticosteroid-resistant.	Poly I-C	92-99	CD274 antigen	Mus musculus	132-137
23781248-4	2013	We compared the immunohistochemical features of pancreatic forkhead box P3 (Foxp3) in the administration of poly I:C in MRL/Mp mice and two types of control mice (BALB/c and C57BL/6).	Poly I-C	108-116	forkhead box P3	Mus musculus	59-74
23781248-4	2013	We compared the immunohistochemical features of pancreatic forkhead box P3 (Foxp3) in the administration of poly I:C in MRL/Mp mice and two types of control mice (BALB/c and C57BL/6).	Poly I-C	108-116	forkhead box P3	Mus musculus	76-81
23781248-8	2013	Our immunohistochemical study of Foxp3 revealed that the infiltration of Foxp3-positive cells increased in poly I:C-treated MRL/Mp mice.	Poly I-C	107-115	forkhead box P3	Mus musculus	33-38
23781248-8	2013	Our immunohistochemical study of Foxp3 revealed that the infiltration of Foxp3-positive cells increased in poly I:C-treated MRL/Mp mice.	Poly I-C	107-115	forkhead box P3	Mus musculus	73-78
23781248-11	2013	MRL/Mp mice treated with poly I:C showed early development of pancreatitis with abundant infiltration of Foxp3-positive cells.	Poly I-C	25-33	forkhead box P3	Mus musculus	105-110
23209319-5	2013	CD11b deficiency reduced inflammatory cytokine induction elicited by polyinosinic:polycytidylic acid (poly I:C; a synthetic dsRNA) in mouse sera and livers, as well as in cultured peritoneal macrophages.	Poly I-C	69-100	integrin alpha M	Mus musculus	0-5
23209319-9	2013	Second, poly I:C induced activation of phagocyte NADPH oxidase in a TLR3-independent, but Mac-1-dependent, manner.	Poly I-C	8-16	toll-like receptor 3	Mus musculus	68-72
23209319-5	2013	CD11b deficiency reduced inflammatory cytokine induction elicited by polyinosinic:polycytidylic acid (poly I:C; a synthetic dsRNA) in mouse sera and livers, as well as in cultured peritoneal macrophages.	Poly I-C	102-110	integrin alpha M	Mus musculus	0-5
23209319-9	2013	Second, poly I:C induced activation of phagocyte NADPH oxidase in a TLR3-independent, but Mac-1-dependent, manner.	Poly I-C	8-16	integrin alpha M	Mus musculus	90-95
23209319-6	2013	dsRNA-binding assay and confocal immunofluorescence showed that Mac-1, especially the CD11b subunit, interacted and colocalized with poly I:C on the surface of macrophages.	Poly I-C	133-141	integrin alpha M	Mus musculus	64-69
23209319-6	2013	dsRNA-binding assay and confocal immunofluorescence showed that Mac-1, especially the CD11b subunit, interacted and colocalized with poly I:C on the surface of macrophages.	Poly I-C	133-141	integrin alpha M	Mus musculus	86-91
23209321-6	2013	Treatment of infected mice with a complex of polyinosinic-polycytidylic acid with poly-L-lysine and carboxymethyl cellulose (Hiltonol), a potent TLR3 agonist, significantly improved survival of both WT and IRAK4(KDKI) mice, thereby providing a potential treatment strategy in both normal and immunocompromised patients.	Poly I-C	45-76	toll-like receptor 3	Mus musculus	145-149
23209321-6	2013	Treatment of infected mice with a complex of polyinosinic-polycytidylic acid with poly-L-lysine and carboxymethyl cellulose (Hiltonol), a potent TLR3 agonist, significantly improved survival of both WT and IRAK4(KDKI) mice, thereby providing a potential treatment strategy in both normal and immunocompromised patients.	Poly I-C	45-76	interleukin-1 receptor-associated kinase 4	Mus musculus	206-211
23028093-3	2013	Concurrently, nicotine treatment attenuated the release of IL-6 and TNF-alpha from poly(I:C)-stimulated macrophages.	Poly I-C	83-92	interleukin 6	Mus musculus	59-63
23028093-3	2013	Concurrently, nicotine treatment attenuated the release of IL-6 and TNF-alpha from poly(I:C)-stimulated macrophages.	Poly I-C	83-92	tumor necrosis factor	Mus musculus	68-77
23028093-4	2013	However, when poly(I:C)-stimulated macrophages were challenged with nicotine plus alpha-bungarotoxin (alpha-BTX), secretion of IL-6 and TNF-alpha was found to be in a level seen with poly(I:C) stimulation only, indicating that alpha7-nAChR, a highly Ca(2+) permeable ion channel sensitive to blockade by alpha-BTX, is involved in this process.	Poly I-C	14-23	interleukin 6	Mus musculus	127-131
23028093-4	2013	However, when poly(I:C)-stimulated macrophages were challenged with nicotine plus alpha-bungarotoxin (alpha-BTX), secretion of IL-6 and TNF-alpha was found to be in a level seen with poly(I:C) stimulation only, indicating that alpha7-nAChR, a highly Ca(2+) permeable ion channel sensitive to blockade by alpha-BTX, is involved in this process.	Poly I-C	14-23	tumor necrosis factor	Mus musculus	136-145
23028093-4	2013	However, when poly(I:C)-stimulated macrophages were challenged with nicotine plus alpha-bungarotoxin (alpha-BTX), secretion of IL-6 and TNF-alpha was found to be in a level seen with poly(I:C) stimulation only, indicating that alpha7-nAChR, a highly Ca(2+) permeable ion channel sensitive to blockade by alpha-BTX, is involved in this process.	Poly I-C	14-23	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	227-239
23028093-4	2013	However, when poly(I:C)-stimulated macrophages were challenged with nicotine plus alpha-bungarotoxin (alpha-BTX), secretion of IL-6 and TNF-alpha was found to be in a level seen with poly(I:C) stimulation only, indicating that alpha7-nAChR, a highly Ca(2+) permeable ion channel sensitive to blockade by alpha-BTX, is involved in this process.	Poly I-C	14-22	interleukin 6	Mus musculus	127-131
23028093-4	2013	However, when poly(I:C)-stimulated macrophages were challenged with nicotine plus alpha-bungarotoxin (alpha-BTX), secretion of IL-6 and TNF-alpha was found to be in a level seen with poly(I:C) stimulation only, indicating that alpha7-nAChR, a highly Ca(2+) permeable ion channel sensitive to blockade by alpha-BTX, is involved in this process.	Poly I-C	14-22	tumor necrosis factor	Mus musculus	136-145
23028093-4	2013	However, when poly(I:C)-stimulated macrophages were challenged with nicotine plus alpha-bungarotoxin (alpha-BTX), secretion of IL-6 and TNF-alpha was found to be in a level seen with poly(I:C) stimulation only, indicating that alpha7-nAChR, a highly Ca(2+) permeable ion channel sensitive to blockade by alpha-BTX, is involved in this process.	Poly I-C	14-22	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	227-239
23441162-8	2013	Poly(I:C) also activated eIF2alpha/ATF4 in a protein kinase R (PKR)-dependent manner.	Poly I-C	0-8	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	63-66
24459828-10	2013	Stimulation with PolyI:C, Pam3CSK4 and LPS also lead to considerable increase of NF-kBp65, while increased levels of inflammatory cytokines were observed for IL-8, TNF and IL-6 in cells treated with PMA and MeV.	Poly I-C	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
23441162-8	2013	Poly(I:C) also activated eIF2alpha/ATF4 in a protein kinase R (PKR)-dependent manner.	Poly I-C	0-8	eukaryotic translation initiation factor 2A	Homo sapiens	25-34
23441162-8	2013	Poly(I:C) also activated eIF2alpha/ATF4 in a protein kinase R (PKR)-dependent manner.	Poly I-C	0-8	activating transcription factor 4	Homo sapiens	35-39
23441162-8	2013	Poly(I:C) also activated eIF2alpha/ATF4 in a protein kinase R (PKR)-dependent manner.	Poly I-C	0-8	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	45-61
24459828-10	2013	Stimulation with PolyI:C, Pam3CSK4 and LPS also lead to considerable increase of NF-kBp65, while increased levels of inflammatory cytokines were observed for IL-8, TNF and IL-6 in cells treated with PMA and MeV.	Poly I-C	17-24	tumor necrosis factor	Homo sapiens	164-167
24459828-10	2013	Stimulation with PolyI:C, Pam3CSK4 and LPS also lead to considerable increase of NF-kBp65, while increased levels of inflammatory cytokines were observed for IL-8, TNF and IL-6 in cells treated with PMA and MeV.	Poly I-C	17-24	interleukin 6	Homo sapiens	172-176
23169587-3	2012	Expression of IFNs was compared by treatment of cells or fish with the dsRNA polyinosinic-polycytidylic acid [poly(I:C)], which induces IFNs via the viral RNA receptors MDA5 and TLR3/TLR22 and with the imidazoquinoline R848, which induces IFNs via TLR7.	Poly I-C	77-108	toll like receptor 7	Homo sapiens	248-252
23169587-3	2012	Expression of IFNs was compared by treatment of cells or fish with the dsRNA polyinosinic-polycytidylic acid [poly(I:C)], which induces IFNs via the viral RNA receptors MDA5 and TLR3/TLR22 and with the imidazoquinoline R848, which induces IFNs via TLR7.	Poly I-C	110-119	toll like receptor 7	Homo sapiens	248-252
23169587-4	2012	Poly(I:C) strongly induced IFNa in cell lines, whereas the other IFNs showed little response, indicating that IFNa is the main IFN subtype induced through the RIG-I/MDA5 pathway.	Poly I-C	0-8	interferon alpha 1	Homo sapiens	27-30
23169587-4	2012	Poly(I:C) strongly induced IFNa in cell lines, whereas the other IFNs showed little response, indicating that IFNa is the main IFN subtype induced through the RIG-I/MDA5 pathway.	Poly I-C	0-8	probable ATP-dependent RNA helicase DDX58	Salmo salar	159-164
23169587-7	2012	Fluorescence in situ hybridization studies showed that poly(I:C) induced IFNa and IFNc in a variety of cells in the head kidney, spleen, gills, liver, and heart, whereas R848 induced coexpression of IFNb and IFNc in distinct cells in head kidney and spleen.	Poly I-C	55-63	IFNc	Salmo salar	82-86
23169587-7	2012	Fluorescence in situ hybridization studies showed that poly(I:C) induced IFNa and IFNc in a variety of cells in the head kidney, spleen, gills, liver, and heart, whereas R848 induced coexpression of IFNb and IFNc in distinct cells in head kidney and spleen.	Poly I-C	55-63	IFNb	Salmo salar	199-203
23169587-7	2012	Fluorescence in situ hybridization studies showed that poly(I:C) induced IFNa and IFNc in a variety of cells in the head kidney, spleen, gills, liver, and heart, whereas R848 induced coexpression of IFNb and IFNc in distinct cells in head kidney and spleen.	Poly I-C	55-63	IFNc	Salmo salar	208-212
22973045-6	2012	Polyinosinic-poly(C) [poly(I:C)], a synthetic dsRNA that is sensed by both RIG-I and MDA-5, induces STAT1 phosphorylation.	Poly I-C	22-31	DExD/H-box helicase 58	Homo sapiens	75-80
24293814-4	2012	Results showed that PolyI.C inhibited viral replication, and increased the level of 2",5"-oligoadenylate synthase mRNA transcripts, a marker of INF-alpha/beta induction.	Poly I-C	20-27	interferon alpha 17	Homo sapiens	144-153
23087404-6	2012	In addition, the activation of IFN-beta by MAVS, influenza virus RNA, polyinosinic-polycytidylic acid, and Sendai virus was enhanced in Ndfip1 knockdown cells.	Poly I-C	70-101	Nedd4 family interacting protein 1	Homo sapiens	136-142
22973045-6	2012	Polyinosinic-poly(C) [poly(I:C)], a synthetic dsRNA that is sensed by both RIG-I and MDA-5, induces STAT1 phosphorylation.	Poly I-C	22-31	interferon induced with helicase C domain 1	Homo sapiens	85-90
22973045-6	2012	Polyinosinic-poly(C) [poly(I:C)], a synthetic dsRNA that is sensed by both RIG-I and MDA-5, induces STAT1 phosphorylation.	Poly I-C	22-31	signal transducer and activator of transcription 1	Homo sapiens	100-105
22882457-8	2012	Injection with Poly I/C failed to increase interleukin (IL)-4 and led to elevated gamma interferon (IFN-gamma) levels released by unstimulated or ESP-stimulated SC.	Poly I-C	15-23	interferon gamma	Mus musculus	82-109
23103873-5	2012	The induction of interferon-beta (IFN-beta) and/or IFN-lambda1 in response to stimulation by the dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) was dependent on TLR3 and UNC-93B in all cells tested.	Poly I-C	112-143	interferon beta 1	Homo sapiens	17-32
23103873-5	2012	The induction of interferon-beta (IFN-beta) and/or IFN-lambda1 in response to stimulation by the dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) was dependent on TLR3 and UNC-93B in all cells tested.	Poly I-C	112-143	interferon beta 1	Homo sapiens	34-42
23103873-5	2012	The induction of interferon-beta (IFN-beta) and/or IFN-lambda1 in response to stimulation by the dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) was dependent on TLR3 and UNC-93B in all cells tested.	Poly I-C	112-143	interferon lambda 1	Homo sapiens	51-62
23103873-5	2012	The induction of interferon-beta (IFN-beta) and/or IFN-lambda1 in response to stimulation by the dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) was dependent on TLR3 and UNC-93B in all cells tested.	Poly I-C	112-143	toll like receptor 3	Homo sapiens	173-177
23103873-5	2012	The induction of interferon-beta (IFN-beta) and/or IFN-lambda1 in response to stimulation by the dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) was dependent on TLR3 and UNC-93B in all cells tested.	Poly I-C	112-143	unc-93 homolog B1, TLR signaling regulator	Homo sapiens	182-189
23169223-5	2012	RESULTS: Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-gamma-inducible protein-10, monocyte chemotactic protein-1, interleukin-8, and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-beta promoter stimulator-1-KO, and TLR4-KO mice.	Poly I-C	14-53	chemokine (C-C motif) ligand 2	Mus musculus	217-247
23169223-5	2012	RESULTS: Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-gamma-inducible protein-10, monocyte chemotactic protein-1, interleukin-8, and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-beta promoter stimulator-1-KO, and TLR4-KO mice.	Poly I-C	14-53	chemokine (C-X-C motif) ligand 15	Mus musculus	249-262
23169223-5	2012	RESULTS: Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-gamma-inducible protein-10, monocyte chemotactic protein-1, interleukin-8, and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-beta promoter stimulator-1-KO, and TLR4-KO mice.	Poly I-C	14-53	TIR domain containing adaptor molecule 1	Homo sapiens	358-362
23169223-5	2012	RESULTS: Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-gamma-inducible protein-10, monocyte chemotactic protein-1, interleukin-8, and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-beta promoter stimulator-1-KO, and TLR4-KO mice.	Poly I-C	14-53	toll-like receptor 4	Mus musculus	413-417
23066157-3	2012	Small interfering RNA-mediated knockdown of Act1 in primary human skin fibroblasts specifically attenuates expression of IFN-beta and IFN-stimulated antiviral genes induced by a synthetic viral mimic, polyinosinic-polycytidylic acid.	Poly I-C	201-232	TRAF3 interacting protein 2	Homo sapiens	44-48
23066157-3	2012	Small interfering RNA-mediated knockdown of Act1 in primary human skin fibroblasts specifically attenuates expression of IFN-beta and IFN-stimulated antiviral genes induced by a synthetic viral mimic, polyinosinic-polycytidylic acid.	Poly I-C	201-232	interferon beta 1	Homo sapiens	121-129
23022505-5	2012	In addition, exposure to poly I:C led to a time dependent release of bioactive tumour necrosis factor (TNF) and interleukin-6 (IL-6) into the supernatants of OVLT and AP cultures.	Poly I-C	25-33	tumor necrosis factor	Rattus norvegicus	79-101
23022505-5	2012	In addition, exposure to poly I:C led to a time dependent release of bioactive tumour necrosis factor (TNF) and interleukin-6 (IL-6) into the supernatants of OVLT and AP cultures.	Poly I-C	25-33	tumor necrosis factor	Rattus norvegicus	103-106
23022505-5	2012	In addition, exposure to poly I:C led to a time dependent release of bioactive tumour necrosis factor (TNF) and interleukin-6 (IL-6) into the supernatants of OVLT and AP cultures.	Poly I-C	25-33	interleukin 6	Rattus norvegicus	112-125
23022505-5	2012	In addition, exposure to poly I:C led to a time dependent release of bioactive tumour necrosis factor (TNF) and interleukin-6 (IL-6) into the supernatants of OVLT and AP cultures.	Poly I-C	25-33	interleukin 6	Rattus norvegicus	127-131
23063848-2	2012	Treatment with polyinosinic:polycytidylic acid (poly(I:C)) induces transient accumulation of IFN-beta mRNA, which involves an increase and a decrease of IFN-beta mRNA.	Poly I-C	15-46	interferon beta 1	Homo sapiens	93-101
23063848-0	2012	Analysis of interferon-beta mRNA stability control after poly(I:C) stimulation using RNA metabolic labeling by ethynyluridine.	Poly I-C	57-66	interferon beta 1	Homo sapiens	12-27
23063848-2	2012	Treatment with polyinosinic:polycytidylic acid (poly(I:C)) induces transient accumulation of IFN-beta mRNA, which involves an increase and a decrease of IFN-beta mRNA.	Poly I-C	15-46	interferon beta 1	Homo sapiens	153-161
23063848-2	2012	Treatment with polyinosinic:polycytidylic acid (poly(I:C)) induces transient accumulation of IFN-beta mRNA, which involves an increase and a decrease of IFN-beta mRNA.	Poly I-C	48-57	interferon beta 1	Homo sapiens	93-101
23063848-2	2012	Treatment with polyinosinic:polycytidylic acid (poly(I:C)) induces transient accumulation of IFN-beta mRNA, which involves an increase and a decrease of IFN-beta mRNA.	Poly I-C	48-57	interferon beta 1	Homo sapiens	153-161
23232191-5	2012	RESULTS: In the hTERT-transfected HNECs, treatment with HWE significantly reduced poly(I:C)-induced  production and release of TSLP in a dose-dependent manner, as well as dexamethasone.	Poly I-C	82-91	telomerase reverse transcriptase	Homo sapiens	16-21
23232191-5	2012	RESULTS: In the hTERT-transfected HNECs, treatment with HWE significantly reduced poly(I:C)-induced  production and release of TSLP in a dose-dependent manner, as well as dexamethasone.	Poly I-C	82-91	thymic stromal lymphopoietin	Homo sapiens	127-131
23232191-6	2012	Treatment with the protein kinase C (PKC) inhibitor GF109203X and NF-kappaB inhibitor IMD-0354 also reduced poly(I:C)-induced TSLP release from hTERT-transfected HNECs.	Poly I-C	108-117	thymic stromal lymphopoietin	Homo sapiens	126-130
23232191-6	2012	Treatment with the protein kinase C (PKC) inhibitor GF109203X and NF-kappaB inhibitor IMD-0354 also reduced poly(I:C)-induced TSLP release from hTERT-transfected HNECs.	Poly I-C	108-117	telomerase reverse transcriptase	Homo sapiens	144-149
23062195-1	2012	Poly I:C is a synthetic dsRNA that can imitate a viral infection and elicit host immune responses by triggering specific pattern-recognition receptors (PRRs) such as toll-like receptor 3 and retinoic acid inducible gene I(RIG-I)-like receptors, including RIG-I and melanoma differentiation-associated gene 5.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	166-186
23116495-2	2012	To date, at least 10 different TLRs have been identified in chickens including TLR2, which binds lipopeptides and other similar ligands such as Pam3CSK4, TLR3, which binds double stranded RNA as well as synthetic molecules such as poly I:C, TLR4, which binds lipopolysaccharide (LPS), and TLR21, which binds CpG DNA motifs.	Poly I-C	231-239	toll-like receptor 2 type-1	Gallus gallus	79-83
23116495-2	2012	To date, at least 10 different TLRs have been identified in chickens including TLR2, which binds lipopeptides and other similar ligands such as Pam3CSK4, TLR3, which binds double stranded RNA as well as synthetic molecules such as poly I:C, TLR4, which binds lipopolysaccharide (LPS), and TLR21, which binds CpG DNA motifs.	Poly I-C	231-239	toll like receptor 3	Gallus gallus	154-158
23116495-2	2012	To date, at least 10 different TLRs have been identified in chickens including TLR2, which binds lipopeptides and other similar ligands such as Pam3CSK4, TLR3, which binds double stranded RNA as well as synthetic molecules such as poly I:C, TLR4, which binds lipopolysaccharide (LPS), and TLR21, which binds CpG DNA motifs.	Poly I-C	231-239	toll like receptor 4	Gallus gallus	241-245
23116495-2	2012	To date, at least 10 different TLRs have been identified in chickens including TLR2, which binds lipopeptides and other similar ligands such as Pam3CSK4, TLR3, which binds double stranded RNA as well as synthetic molecules such as poly I:C, TLR4, which binds lipopolysaccharide (LPS), and TLR21, which binds CpG DNA motifs.	Poly I-C	231-239	toll like receptor 21	Gallus gallus	289-294
23062195-1	2012	Poly I:C is a synthetic dsRNA that can imitate a viral infection and elicit host immune responses by triggering specific pattern-recognition receptors (PRRs) such as toll-like receptor 3 and retinoic acid inducible gene I(RIG-I)-like receptors, including RIG-I and melanoma differentiation-associated gene 5.	Poly I-C	0-8	DExD/H-box helicase 58	Homo sapiens	222-227
23062195-1	2012	Poly I:C is a synthetic dsRNA that can imitate a viral infection and elicit host immune responses by triggering specific pattern-recognition receptors (PRRs) such as toll-like receptor 3 and retinoic acid inducible gene I(RIG-I)-like receptors, including RIG-I and melanoma differentiation-associated gene 5.	Poly I-C	0-8	DExD/H-box helicase 58	Homo sapiens	255-260
22982325-11	2012	NOD1 showed a significant enhancement after LPS stimulation, but NOD2 increased more significantly after PolyI:C invasion, indicating that NOD1 and NOD2 may exert different effects on the eradication of bacteria and virus.	Poly I-C	105-112	nucleotide-binding oligomerization domain-containing protein 2	Ictalurus punctatus	65-69
22982325-11	2012	NOD1 showed a significant enhancement after LPS stimulation, but NOD2 increased more significantly after PolyI:C invasion, indicating that NOD1 and NOD2 may exert different effects on the eradication of bacteria and virus.	Poly I-C	105-112	nucleotide binding oligomerization domain containing 1	Homo sapiens	139-143
22982325-11	2012	NOD1 showed a significant enhancement after LPS stimulation, but NOD2 increased more significantly after PolyI:C invasion, indicating that NOD1 and NOD2 may exert different effects on the eradication of bacteria and virus.	Poly I-C	105-112	nucleotide-binding oligomerization domain-containing protein 2	Ictalurus punctatus	148-152
22915814-4	2012	Intranasal pretreatment of aged mice with poly(I C) (a TLR3 agonist) and, to a lesser extent, CpG, R848, or lipopolysaccharide (TLR9, TLR7/8, or TLR4 agonists), provided a high level of protection [90% to 100% survival rate after poly(I C) treatment] against lethal MA15 or IAV challenge and reduced pathological changes and virus loads in the lungs at early times after infection.	Poly I-C	42-50	toll-like receptor 3	Mus musculus	55-59
23090076-0	2012	Combined TLR stimulation with Pam3Cys and Poly I: C enhances Flt3-ligand dendritic cell activation for tumor immunotherapy.	Poly I-C	42-51	FMS-like tyrosine kinase 3 ligand	Mus musculus	61-72
22592217-5	2012	Furthermore, we observed that PRRSV infection significantly reduced the induction of IFN-alpha by Poly I:C treatment; and virus replication is essential to the effect since heat-inactivated PRRSV has no effect on IFN-alpha induction by Poly I:C.	Poly I-C	98-106	interferon alpha 1	Homo sapiens	85-94
22915814-5	2012	Poly(I C) pretreatment upregulated beta interferon (IFN-beta), IFN-gamma, IL-1beta, and tumor necrosis factor (TNF) gene expression in the lungs.	Poly I-C	0-8	interferon beta 1	Homo sapiens	35-60
22915814-5	2012	Poly(I C) pretreatment upregulated beta interferon (IFN-beta), IFN-gamma, IL-1beta, and tumor necrosis factor (TNF) gene expression in the lungs.	Poly I-C	0-8	interferon gamma	Homo sapiens	63-72
22915814-5	2012	Poly(I C) pretreatment upregulated beta interferon (IFN-beta), IFN-gamma, IL-1beta, and tumor necrosis factor (TNF) gene expression in the lungs.	Poly I-C	0-8	interleukin 1 beta	Homo sapiens	74-82
22915814-5	2012	Poly(I C) pretreatment upregulated beta interferon (IFN-beta), IFN-gamma, IL-1beta, and tumor necrosis factor (TNF) gene expression in the lungs.	Poly I-C	0-8	tumor necrosis factor	Homo sapiens	88-109
22915814-5	2012	Poly(I C) pretreatment upregulated beta interferon (IFN-beta), IFN-gamma, IL-1beta, and tumor necrosis factor (TNF) gene expression in the lungs.	Poly I-C	0-8	tumor necrosis factor	Homo sapiens	111-114
23036591-16	2012	Exposure to BaP affected mo-DC function as demonstrated by decreased IL6 expression induced by PolyI:C, without affecting indoleamine 2,3 dioxygenase (IDO)1 expression.	Poly I-C	95-102	interleukin 6	Homo sapiens	69-72
22983393-0	2012	Toll-like receptor 3 agonist Poly I:C protects against simulated cerebral ischemia in vitro and in vivo.	Poly I-C	29-37	toll-like receptor 3	Mus musculus	0-20
22983393-1	2012	AIM: To examine the neuroprotective effects of the Toll-like receptor 3 (TLR3) agonist Poly I:C in acute ischemic models in vitro and in vivo.	Poly I-C	87-95	toll-like receptor 3	Mus musculus	51-71
22983393-1	2012	AIM: To examine the neuroprotective effects of the Toll-like receptor 3 (TLR3) agonist Poly I:C in acute ischemic models in vitro and in vivo.	Poly I-C	87-95	toll-like receptor 3	Mus musculus	73-77
22983393-11	2012	Poly I:C significantly upregulated TRIF expression accompanied by increased downstream IFNbeta production.	Poly I-C	0-8	toll-like receptor adaptor molecule 1	Mus musculus	35-39
22983393-12	2012	Moreover, Poly I:C significantly suppressed the pro-inflammatory cytokines TNFalpha and IL-6 production.	Poly I-C	10-18	tumor necrosis factor	Mus musculus	75-83
22983393-12	2012	Moreover, Poly I:C significantly suppressed the pro-inflammatory cytokines TNFalpha and IL-6 production.	Poly I-C	10-18	interleukin 6	Mus musculus	88-92
22983393-14	2012	CONCLUSION: Poly I:C pretreatment exerts neuroprotective and anti-inflammatory effects in the simulated cerebral ischemia models, and the neuroprotection is at least in part due to the activation of the TLR3-TRIF pathway.	Poly I-C	12-20	toll-like receptor 3	Mus musculus	203-207
22983393-14	2012	CONCLUSION: Poly I:C pretreatment exerts neuroprotective and anti-inflammatory effects in the simulated cerebral ischemia models, and the neuroprotection is at least in part due to the activation of the TLR3-TRIF pathway.	Poly I-C	12-20	toll-like receptor adaptor molecule 1	Mus musculus	208-212
22882449-3	2012	The aim of the study was to evaluate the activity of polyinosinic-polycytidylic acid [poly(I:C)] on IL-17A production by CD1d-activated iNKT cells.	Poly I-C	53-84	interleukin 17A	Mus musculus	100-106
22882449-3	2012	The aim of the study was to evaluate the activity of polyinosinic-polycytidylic acid [poly(I:C)] on IL-17A production by CD1d-activated iNKT cells.	Poly I-C	53-84	CD1d1 antigen	Mus musculus	121-125
22882449-3	2012	The aim of the study was to evaluate the activity of polyinosinic-polycytidylic acid [poly(I:C)] on IL-17A production by CD1d-activated iNKT cells.	Poly I-C	86-95	interleukin 17A	Mus musculus	100-106
22882449-3	2012	The aim of the study was to evaluate the activity of polyinosinic-polycytidylic acid [poly(I:C)] on IL-17A production by CD1d-activated iNKT cells.	Poly I-C	86-95	CD1d1 antigen	Mus musculus	121-125
22581266-13	2012	Poly (I:C)-induced TNF-alpha, and IL-6 in vitro demonstrated no difference between GS/GS mice and WT mice.	Poly I-C	0-10	tumor necrosis factor	Mus musculus	19-28
22809727-8	2012	Moreover, FN reduced TNF-alpha production induced by polyI:C (TLR3 ligand), and imiquimod (TLR7 ligand), but not by LPS (TLR4 ligand), or a non-CpG pDNA/cationic liposome complex.	Poly I-C	53-60	fibronectin 1	Mus musculus	10-12
22809727-8	2012	Moreover, FN reduced TNF-alpha production induced by polyI:C (TLR3 ligand), and imiquimod (TLR7 ligand), but not by LPS (TLR4 ligand), or a non-CpG pDNA/cationic liposome complex.	Poly I-C	53-60	tumor necrosis factor	Mus musculus	21-30
22762377-3	2012	While poly(I:C) induced IL-8 gene expression was solely inhibited by the NF-kappaB inhibitor III, MCP-1 gene induction was also blocked by PKA, p38 MAPK and JAK-STAT inhibitors.	Poly I-C	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
22762377-3	2012	While poly(I:C) induced IL-8 gene expression was solely inhibited by the NF-kappaB inhibitor III, MCP-1 gene induction was also blocked by PKA, p38 MAPK and JAK-STAT inhibitors.	Poly I-C	6-14	C-C motif chemokine ligand 2	Homo sapiens	98-103
22762377-6	2012	These data are indicative for distinct signalling pathways in the poly(I:C)-induced gene expression of IL-8 and MCP-1 in HaCaT keratinocytes.	Poly I-C	66-75	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
22762377-6	2012	These data are indicative for distinct signalling pathways in the poly(I:C)-induced gene expression of IL-8 and MCP-1 in HaCaT keratinocytes.	Poly I-C	66-75	C-C motif chemokine ligand 2	Homo sapiens	112-117
22750548-0	2012	poly(I:C) costimulation induces a stronger antiviral chemokine and granzyme B release in human CD4 T cells than CD28 costimulation.	Poly I-C	0-8	granzyme B	Homo sapiens	67-77
22730064-6	2012	Stimulation with RSV or Poly(I:C) induced IFN-beta expression, which resulted in an increased expression of the viral receptors TLR3 and RIG-I, as well as an increased NOD2 expression.	Poly I-C	24-32	interferon beta 1	Homo sapiens	42-50
22730064-6	2012	Stimulation with RSV or Poly(I:C) induced IFN-beta expression, which resulted in an increased expression of the viral receptors TLR3 and RIG-I, as well as an increased NOD2 expression.	Poly I-C	24-32	nucleotide binding oligomerization domain containing 2	Homo sapiens	168-172
22750548-0	2012	poly(I:C) costimulation induces a stronger antiviral chemokine and granzyme B release in human CD4 T cells than CD28 costimulation.	Poly I-C	0-8	CD4 molecule	Homo sapiens	95-98
22750548-4	2012	Our study shows that costimulation of CD4 T cells by poly(I:C) enhanced CD3-induced production of IP-10, MIP1-alpha/beta, RANTES, and granzyme B involved in antiviral activity more than anti-CD28 mAb.	Poly I-C	53-62	CD4 molecule	Homo sapiens	38-41
22750548-4	2012	Our study shows that costimulation of CD4 T cells by poly(I:C) enhanced CD3-induced production of IP-10, MIP1-alpha/beta, RANTES, and granzyme B involved in antiviral activity more than anti-CD28 mAb.	Poly I-C	53-62	C-X-C motif chemokine ligand 10	Homo sapiens	98-103
22750548-4	2012	Our study shows that costimulation of CD4 T cells by poly(I:C) enhanced CD3-induced production of IP-10, MIP1-alpha/beta, RANTES, and granzyme B involved in antiviral activity more than anti-CD28 mAb.	Poly I-C	53-62	C-C motif chemokine ligand 3	Homo sapiens	105-115
22750548-4	2012	Our study shows that costimulation of CD4 T cells by poly(I:C) enhanced CD3-induced production of IP-10, MIP1-alpha/beta, RANTES, and granzyme B involved in antiviral activity more than anti-CD28 mAb.	Poly I-C	53-62	C-C motif chemokine ligand 5	Homo sapiens	122-128
22750548-4	2012	Our study shows that costimulation of CD4 T cells by poly(I:C) enhanced CD3-induced production of IP-10, MIP1-alpha/beta, RANTES, and granzyme B involved in antiviral activity more than anti-CD28 mAb.	Poly I-C	53-62	granzyme B	Homo sapiens	134-144
22750548-4	2012	Our study shows that costimulation of CD4 T cells by poly(I:C) enhanced CD3-induced production of IP-10, MIP1-alpha/beta, RANTES, and granzyme B involved in antiviral activity more than anti-CD28 mAb.	Poly I-C	53-62	CD28 molecule	Homo sapiens	191-195
22750548-6	2012	Combined CD3 and poly(I:C) stimulation significantly enhanced the transcription of IRF7 and additionally, NF-kappaBp65 phosphorylation, which might be involved in the induction of antiviral chemokines and the enhanced cytotoxic activity of poly(I:C)-treated CD4 T cells.	Poly I-C	17-25	interferon regulatory factor 7	Homo sapiens	83-87
22750548-6	2012	Combined CD3 and poly(I:C) stimulation significantly enhanced the transcription of IRF7 and additionally, NF-kappaBp65 phosphorylation, which might be involved in the induction of antiviral chemokines and the enhanced cytotoxic activity of poly(I:C)-treated CD4 T cells.	Poly I-C	17-25	RELA proto-oncogene, NF-kB subunit	Homo sapiens	106-118
22750548-6	2012	Combined CD3 and poly(I:C) stimulation significantly enhanced the transcription of IRF7 and additionally, NF-kappaBp65 phosphorylation, which might be involved in the induction of antiviral chemokines and the enhanced cytotoxic activity of poly(I:C)-treated CD4 T cells.	Poly I-C	17-25	CD4 molecule	Homo sapiens	258-261
22750548-6	2012	Combined CD3 and poly(I:C) stimulation significantly enhanced the transcription of IRF7 and additionally, NF-kappaBp65 phosphorylation, which might be involved in the induction of antiviral chemokines and the enhanced cytotoxic activity of poly(I:C)-treated CD4 T cells.	Poly I-C	240-248	interferon regulatory factor 7	Homo sapiens	83-87
22750548-6	2012	Combined CD3 and poly(I:C) stimulation significantly enhanced the transcription of IRF7 and additionally, NF-kappaBp65 phosphorylation, which might be involved in the induction of antiviral chemokines and the enhanced cytotoxic activity of poly(I:C)-treated CD4 T cells.	Poly I-C	240-248	RELA proto-oncogene, NF-kB subunit	Homo sapiens	106-118
22750548-6	2012	Combined CD3 and poly(I:C) stimulation significantly enhanced the transcription of IRF7 and additionally, NF-kappaBp65 phosphorylation, which might be involved in the induction of antiviral chemokines and the enhanced cytotoxic activity of poly(I:C)-treated CD4 T cells.	Poly I-C	240-248	CD4 molecule	Homo sapiens	258-261
22750548-9	2012	In contrast to poly(I:C), anti-CD28 mAb was essential for proliferation of anti-CD3-stimulated CD4 T cells; however, poly(I:C) further increased the anti-CD28/anti-CD3-mediated proliferation.	Poly I-C	117-125	CD28 molecule	Homo sapiens	154-158
22750548-10	2012	These results indicate that poly(I:C)- and anti-CD28 mAb-induced signaling differ in their costimulatory effect on the CD3-driven, antiviral chemokine release and proinflammatory cytokine secretion in freshly isolated human CD4 T cells.	Poly I-C	28-36	CD4 molecule	Homo sapiens	224-227
22797253-0	2012	Temporally designed treatment of melanoma cells by ATRA and polyI: C results in enhanced chemokine and IFNbeta secretion controlled differently by TLR3 and MDA5.	Poly I-C	60-68	interferon beta 1	Homo sapiens	103-110
22914602-4	2012	OBJECTIVE: To study the effects and signaling pathways of formoterol and salmeterol on polyriboinosinic polyribocytidylic acid (poly I:C)-induced IP-10 expression in BEAS-2B cells.	Poly I-C	87-126	C-X-C motif chemokine ligand 10	Homo sapiens	146-151
22797253-0	2012	Temporally designed treatment of melanoma cells by ATRA and polyI: C results in enhanced chemokine and IFNbeta secretion controlled differently by TLR3 and MDA5.	Poly I-C	60-68	toll like receptor 3	Homo sapiens	147-151
22797253-0	2012	Temporally designed treatment of melanoma cells by ATRA and polyI: C results in enhanced chemokine and IFNbeta secretion controlled differently by TLR3 and MDA5.	Poly I-C	60-68	interferon induced with helicase C domain 1	Homo sapiens	156-160
22797253-2	2012	All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro.	Poly I-C	68-75	toll like receptor 3	Homo sapiens	100-120
22797253-2	2012	All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro.	Poly I-C	68-75	toll like receptor 3	Homo sapiens	122-126
22797253-2	2012	All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro.	Poly I-C	68-75	interferon induced with helicase C domain 1	Homo sapiens	132-136
22797253-2	2012	All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro.	Poly I-C	68-75	toll like receptor 3	Homo sapiens	169-173
22797253-2	2012	All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro.	Poly I-C	68-75	interferon induced with helicase C domain 1	Homo sapiens	178-182
22797253-5	2012	Furthermore, the supernatants of ATRA+polyI:C-activated cultures increased the migration of both human monocyte-derived macrophages and CD1a dendritic cells significantly as compared with the supernatants of cells treated with either ATRA or polyI:C, and this effect occurred in a TLR3-dependent manner.	Poly I-C	38-45	CD1a molecule	Homo sapiens	136-140
22797253-5	2012	Furthermore, the supernatants of ATRA+polyI:C-activated cultures increased the migration of both human monocyte-derived macrophages and CD1a dendritic cells significantly as compared with the supernatants of cells treated with either ATRA or polyI:C, and this effect occurred in a TLR3-dependent manner.	Poly I-C	38-45	toll like receptor 3	Homo sapiens	281-285
22797253-6	2012	In conclusion, consecutive treatment with ATRA and polyI:C results in strong, TLR3/MDA5-mediated chemokine and IFN responses in cultured human melanoma cells, which triggers a functional migratory response in professional antigen-presenting cells.	Poly I-C	51-58	toll like receptor 3	Homo sapiens	78-82
22797253-6	2012	In conclusion, consecutive treatment with ATRA and polyI:C results in strong, TLR3/MDA5-mediated chemokine and IFN responses in cultured human melanoma cells, which triggers a functional migratory response in professional antigen-presenting cells.	Poly I-C	51-58	interferon induced with helicase C domain 1	Homo sapiens	83-87
22797253-6	2012	In conclusion, consecutive treatment with ATRA and polyI:C results in strong, TLR3/MDA5-mediated chemokine and IFN responses in cultured human melanoma cells, which triggers a functional migratory response in professional antigen-presenting cells.	Poly I-C	51-58	interferon alpha 1	Homo sapiens	111-114
22765163-6	2012	RESULTS: TNF-alpha production was enhanced by airway exposure to low and high doses of poly[I:C].	Poly I-C	87-95	tumor necrosis factor	Mus musculus	9-18
22904303-4	2012	Polyinosinic-polycytidylic acid [Poly (I:C)], a dsRNA receptor ligand, activates Rac via its guanine nucleotide exchange factor Tiam; this leads to the activation of cytokine genes and, paradoxically, downregulation of the Tipe2 gene.	Poly I-C	0-31	thymoma viral proto-oncogene 1	Mus musculus	81-84
22904303-4	2012	Polyinosinic-polycytidylic acid [Poly (I:C)], a dsRNA receptor ligand, activates Rac via its guanine nucleotide exchange factor Tiam; this leads to the activation of cytokine genes and, paradoxically, downregulation of the Tipe2 gene.	Poly I-C	0-31	tumor necrosis factor, alpha-induced protein 8-like 2	Mus musculus	223-228
22824974-10	2012	DEX, BUD, and FP suppressed MUC5AC protein expression induced by a combination of TGF-alpha and polyI:C in a dose-dependent manner.	Poly I-C	96-103	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	28-34
22765163-10	2012	Moreover, the Th2 cell response induced by sensitization with OVA plus low-dose poly[I:C], which was abolished in TNF-alpha-deficient mice, was restored in these mice upon addition of recombinant TNF-alpha.	Poly I-C	80-88	heart and neural crest derivatives expressed 2	Mus musculus	14-17
22765163-10	2012	Moreover, the Th2 cell response induced by sensitization with OVA plus low-dose poly[I:C], which was abolished in TNF-alpha-deficient mice, was restored in these mice upon addition of recombinant TNF-alpha.	Poly I-C	80-88	tumor necrosis factor	Mus musculus	114-123
22765163-10	2012	Moreover, the Th2 cell response induced by sensitization with OVA plus low-dose poly[I:C], which was abolished in TNF-alpha-deficient mice, was restored in these mice upon addition of recombinant TNF-alpha.	Poly I-C	80-88	tumor necrosis factor	Mus musculus	196-205
23028330-3	2012	We found that poly(I:C)- and LPS-stimulation of MDMs abrogated infection by CCR5-using, macrophage-tropic HIV-1, and by vesicular stomatitis virus glycoprotein-pseudotyped HIV-1 virions, while TLR2, TLR7 or TLR9 agonists only partially reduced infection to varying extent.	Poly I-C	14-23	C-C motif chemokine receptor 5	Homo sapiens	76-80
22249201-4	2012	We found that in response to poly I:C and LPS, monocytes, MDM and MDDC express a subtype pattern restricted primarily to IFN-beta and IFN-lambda1.	Poly I-C	29-37	CYMD	Homo sapiens	66-70
22249201-4	2012	We found that in response to poly I:C and LPS, monocytes, MDM and MDDC express a subtype pattern restricted primarily to IFN-beta and IFN-lambda1.	Poly I-C	29-37	interferon beta 1	Homo sapiens	121-129
22249201-4	2012	We found that in response to poly I:C and LPS, monocytes, MDM and MDDC express a subtype pattern restricted primarily to IFN-beta and IFN-lambda1.	Poly I-C	29-37	interferon lambda 1	Homo sapiens	134-145
23162785-1	2012	Antitumor effect of PolyI:C (a viral dsRNA analog) has been attributed to dendritic cell (DC)-maturation activity, that drives antitumor NK cells, DC cross-presentation, cytotoxic T lymphocytes and many IFN-inducible genes.	Poly I-C	20-27	interferon alpha 1	Homo sapiens	203-206
23028330-3	2012	We found that poly(I:C)- and LPS-stimulation of MDMs abrogated infection by CCR5-using, macrophage-tropic HIV-1, and by vesicular stomatitis virus glycoprotein-pseudotyped HIV-1 virions, while TLR2, TLR7 or TLR9 agonists only partially reduced infection to varying extent.	Poly I-C	14-23	toll like receptor 7	Homo sapiens	199-203
23028330-3	2012	We found that poly(I:C)- and LPS-stimulation of MDMs abrogated infection by CCR5-using, macrophage-tropic HIV-1, and by vesicular stomatitis virus glycoprotein-pseudotyped HIV-1 virions, while TLR2, TLR7 or TLR9 agonists only partially reduced infection to varying extent.	Poly I-C	14-23	toll like receptor 9	Homo sapiens	207-211
22892369-4	2012	In the present study, we examined the effect of polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA (dsRNA) that mimics viral dsRNAs, on MDA5 expression using primary culture of human mesangial cells.	Poly I-C	48-79	interferon induced with helicase C domain 1	Homo sapiens	161-165
22892369-4	2012	In the present study, we examined the effect of polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA (dsRNA) that mimics viral dsRNAs, on MDA5 expression using primary culture of human mesangial cells.	Poly I-C	81-88	interferon induced with helicase C domain 1	Homo sapiens	161-165
22647506-8	2012	We also found increased ERK phosphorylation both in acute hypoxia and poly I:C treatment.	Poly I-C	70-78	mitogen-activated protein kinase 1	Mus musculus	24-27
22851595-6	2012	A defect in polyinosinic-polycytidylic acid-induced TLR3 responses can be detected in fibroblasts heterozygous for G159A but not for D50A TBK1.	Poly I-C	12-43	toll like receptor 3	Homo sapiens	52-56
22647506-9	2012	We further showed that the pre-treatment of TLR3 neutralizing antibody or ERK inhibitor (PD98059) 2 h prior to acute hypoxia or poly I:C treatment completely abrogated ERK phosphorylation and TF activation.	Poly I-C	128-136	toll-like receptor 3	Mus musculus	44-48
22647506-9	2012	We further showed that the pre-treatment of TLR3 neutralizing antibody or ERK inhibitor (PD98059) 2 h prior to acute hypoxia or poly I:C treatment completely abrogated ERK phosphorylation and TF activation.	Poly I-C	128-136	mitogen-activated protein kinase 1	Mus musculus	74-77
22647506-9	2012	We further showed that the pre-treatment of TLR3 neutralizing antibody or ERK inhibitor (PD98059) 2 h prior to acute hypoxia or poly I:C treatment completely abrogated ERK phosphorylation and TF activation.	Poly I-C	128-136	mitogen-activated protein kinase 1	Mus musculus	168-171
22647506-9	2012	We further showed that the pre-treatment of TLR3 neutralizing antibody or ERK inhibitor (PD98059) 2 h prior to acute hypoxia or poly I:C treatment completely abrogated ERK phosphorylation and TF activation.	Poly I-C	128-136	coagulation factor III	Mus musculus	192-194
21898393-8	2012	More importantly, intravenous injection with EDA-HPVE7 in combination with the TLR ligand polyinosinic-polycytidylic acid (pIC), or with low doses of cyclophosphamide and the TLR9 ligand CpG-B complexed in cationic lipids, were able to eradicate large established TC-1 tumors (1.2 cm in diameter).	Poly I-C	123-126	ectodysplasin A	Homo sapiens	45-54
22572822-3	2012	In this study, we investigated the capacity of the TLR3 agonist polyriboinosinic-polyribocytidylic acid (poly(I:C)) to promote the healing of skin wounds in humans and mice.	Poly I-C	64-103	toll like receptor 3	Homo sapiens	51-55
22572822-3	2012	In this study, we investigated the capacity of the TLR3 agonist polyriboinosinic-polyribocytidylic acid (poly(I:C)) to promote the healing of skin wounds in humans and mice.	Poly I-C	105-114	toll like receptor 3	Homo sapiens	51-55
22572822-6	2012	Further studies revealed that poly(I:C) treatment resulted in enhanced recruitment of neutrophils and macrophages in association with upregulation of a chemokine, macrophage inflammatory protein-2 (MIP-2/CXCL2), in the wounds.	Poly I-C	30-39	chemokine (C-X-C motif) ligand 2	Mus musculus	163-196
22572822-6	2012	Further studies revealed that poly(I:C) treatment resulted in enhanced recruitment of neutrophils and macrophages in association with upregulation of a chemokine, macrophage inflammatory protein-2 (MIP-2/CXCL2), in the wounds.	Poly I-C	30-39	chemokine (C-X-C motif) ligand 2	Mus musculus	198-203
22572822-6	2012	Further studies revealed that poly(I:C) treatment resulted in enhanced recruitment of neutrophils and macrophages in association with upregulation of a chemokine, macrophage inflammatory protein-2 (MIP-2/CXCL2), in the wounds.	Poly I-C	30-39	chemokine (C-X-C motif) ligand 2	Mus musculus	204-209
22675026-2	2012	Here we show that Cot/tpl2 regulates RSK, S6 ribosomal protein, and 4E-BP phosphorylation after stimulation of bone marrow-derived macrophages with lipopolysaccharide (LPS), poly I:C, or zymosan.	Poly I-C	174-182	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	18-26
22934250-0	2012	Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c(+)/CD8alpha(+) dendritic cells.	Poly I-C	56-63	toll-like receptor adaptor molecule 1	Mus musculus	79-86
22934250-0	2012	Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c(+)/CD8alpha(+) dendritic cells.	Poly I-C	56-63	integrin subunit alpha X	Homo sapiens	104-109
22934250-3	2012	Endosomal TLR3 and cytoplasmic RIG-I/MDA5 are reportedly responsible for polyI:C sensing and presumed to deliver signal for cross-presentation via TICAM-1 (TRIF) and IPS-1 (MAVS, Cardif, VISA) adaptors, respectively.	Poly I-C	73-80	mitochondrial antiviral signaling protein	Mus musculus	187-191
22934250-0	2012	Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c(+)/CD8alpha(+) dendritic cells.	Poly I-C	56-63	CD8a molecule	Homo sapiens	113-121
22934250-2	2012	DC (BM or spleen CD8alpha(+)) have sensors for dsRNA including polyI:C to signal facilitating cross-presentation.	Poly I-C	63-70	CD8 antigen, alpha chain	Mus musculus	17-25
22934250-3	2012	Endosomal TLR3 and cytoplasmic RIG-I/MDA5 are reportedly responsible for polyI:C sensing and presumed to deliver signal for cross-presentation via TICAM-1 (TRIF) and IPS-1 (MAVS, Cardif, VISA) adaptors, respectively.	Poly I-C	73-80	toll-like receptor 3	Mus musculus	10-14
22934250-3	2012	Endosomal TLR3 and cytoplasmic RIG-I/MDA5 are reportedly responsible for polyI:C sensing and presumed to deliver signal for cross-presentation via TICAM-1 (TRIF) and IPS-1 (MAVS, Cardif, VISA) adaptors, respectively.	Poly I-C	73-80	DEAD/H box helicase 58	Mus musculus	31-36
22934250-3	2012	Endosomal TLR3 and cytoplasmic RIG-I/MDA5 are reportedly responsible for polyI:C sensing and presumed to deliver signal for cross-presentation via TICAM-1 (TRIF) and IPS-1 (MAVS, Cardif, VISA) adaptors, respectively.	Poly I-C	73-80	interferon induced with helicase C domain 1	Mus musculus	37-41
22934250-3	2012	Endosomal TLR3 and cytoplasmic RIG-I/MDA5 are reportedly responsible for polyI:C sensing and presumed to deliver signal for cross-presentation via TICAM-1 (TRIF) and IPS-1 (MAVS, Cardif, VISA) adaptors, respectively.	Poly I-C	73-80	toll-like receptor adaptor molecule 1	Mus musculus	156-160
22934250-3	2012	Endosomal TLR3 and cytoplasmic RIG-I/MDA5 are reportedly responsible for polyI:C sensing and presumed to deliver signal for cross-presentation via TICAM-1 (TRIF) and IPS-1 (MAVS, Cardif, VISA) adaptors, respectively.	Poly I-C	73-80	mitochondrial antiviral signaling protein	Mus musculus	166-171
22934250-3	2012	Endosomal TLR3 and cytoplasmic RIG-I/MDA5 are reportedly responsible for polyI:C sensing and presumed to deliver signal for cross-presentation via TICAM-1 (TRIF) and IPS-1 (MAVS, Cardif, VISA) adaptors, respectively.	Poly I-C	73-80	mitochondrial antiviral signaling protein	Mus musculus	173-177
22934250-3	2012	Endosomal TLR3 and cytoplasmic RIG-I/MDA5 are reportedly responsible for polyI:C sensing and presumed to deliver signal for cross-presentation via TICAM-1 (TRIF) and IPS-1 (MAVS, Cardif, VISA) adaptors, respectively.	Poly I-C	73-80	mitochondrial antiviral signaling protein	Mus musculus	179-185
22589540-6	2012	Poly(I:C)-induced NK cell-mediated acute hepatitis was observed to be attenuated in Btk(-/-) mice or the mice with in vivo administration of the Btk inhibitor.	Poly I-C	0-9	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	84-87
22589540-6	2012	Poly(I:C)-induced NK cell-mediated acute hepatitis was observed to be attenuated in Btk(-/-) mice or the mice with in vivo administration of the Btk inhibitor.	Poly I-C	0-9	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	145-148
23277704-6	2012	There was an up-regulation of interferon (IFN)-beta, TLR-3, and Toll/interleukin 1 receptor domain-containing adaptor protein inducing IFN-beta (TRIF) at 6 h post-treatment in the spleen via IM administration of polyI:C.	Poly I-C	212-219	interferon omega 1	Gallus gallus	135-143
22634298-3	2012	Although polyriboinosinic: polyribocytidylic acid (PIC), a TLR3 agonist, has been reported as a promising adjuvant for cancer vaccines, its immunopotency may be limited by insufficient cellular penetration.	Poly I-C	9-49	toll-like receptor 3	Mus musculus	59-63
22634299-1	2012	CpG oligonucleotides and polyinosinic:polycytidylic acid (poly I:C) are toll-like receptor (TLR) agonists that mimic the immunostimulatory properties of bacterial DNA and double-stranded viral RNA respectively, and which have exhibited potential to serve as vaccine adjuvants in previous experiments.	Poly I-C	25-56	toll-like receptor 12	Salmo salar	72-90
22634299-1	2012	CpG oligonucleotides and polyinosinic:polycytidylic acid (poly I:C) are toll-like receptor (TLR) agonists that mimic the immunostimulatory properties of bacterial DNA and double-stranded viral RNA respectively, and which have exhibited potential to serve as vaccine adjuvants in previous experiments.	Poly I-C	25-56	toll-like receptor 12	Salmo salar	92-95
22634299-1	2012	CpG oligonucleotides and polyinosinic:polycytidylic acid (poly I:C) are toll-like receptor (TLR) agonists that mimic the immunostimulatory properties of bacterial DNA and double-stranded viral RNA respectively, and which have exhibited potential to serve as vaccine adjuvants in previous experiments.	Poly I-C	58-66	toll-like receptor 12	Salmo salar	72-90
22634299-1	2012	CpG oligonucleotides and polyinosinic:polycytidylic acid (poly I:C) are toll-like receptor (TLR) agonists that mimic the immunostimulatory properties of bacterial DNA and double-stranded viral RNA respectively, and which have exhibited potential to serve as vaccine adjuvants in previous experiments.	Poly I-C	58-66	toll-like receptor 12	Salmo salar	92-95
22627090-5	2012	We observed that Poly I:C and LPS alone, but not Pam2CSK4 or fucoidan increased the levels of p-IkappaBalpha.	Poly I-C	17-25	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	96-108
23277704-6	2012	There was an up-regulation of interferon (IFN)-beta, TLR-3, and Toll/interleukin 1 receptor domain-containing adaptor protein inducing IFN-beta (TRIF) at 6 h post-treatment in the spleen via IM administration of polyI:C.	Poly I-C	212-219	toll like receptor adaptor molecule 1	Gallus gallus	145-149
22459580-7	2012	DF1 cells transfected with polyinosinic-polycytidylic acid (poly(I:C)) had significantly (p<0.05) increased fold changes in chicken MDA5 and IFN-beta mRNA expression as compared to those in the controls.	Poly I-C	27-58	interferon induced with helicase C domain 1	Gallus gallus	135-139
22459580-7	2012	DF1 cells transfected with polyinosinic-polycytidylic acid (poly(I:C)) had significantly (p<0.05) increased fold changes in chicken MDA5 and IFN-beta mRNA expression as compared to those in the controls.	Poly I-C	27-58	interferon omega 1	Gallus gallus	144-152
22459580-7	2012	DF1 cells transfected with polyinosinic-polycytidylic acid (poly(I:C)) had significantly (p<0.05) increased fold changes in chicken MDA5 and IFN-beta mRNA expression as compared to those in the controls.	Poly I-C	60-69	interferon induced with helicase C domain 1	Gallus gallus	135-139
22459580-7	2012	DF1 cells transfected with polyinosinic-polycytidylic acid (poly(I:C)) had significantly (p<0.05) increased fold changes in chicken MDA5 and IFN-beta mRNA expression as compared to those in the controls.	Poly I-C	60-69	interferon omega 1	Gallus gallus	144-152
22689946-6	2012	During an acute lung response to Staphylococcus aureus enterotoxin, peripheral injection of poly(I:C) manifested a suppressive process by inhibiting the differentiation of both antigen- and IL-33-responsive CD8 effectors systemically.	Poly I-C	92-100	interleukin 33	Mus musculus	190-195
22203435-5	2012	Poly(I:C) was transfected into these cancer cells to stimulate melanoma differentiation-associated gene (MDA) 5, which is a cytoplasmic adjuvant receptor.	Poly I-C	0-8	interferon induced with helicase C domain 1	Homo sapiens	63-111
22203435-6	2012	Poly(I:C) transfection significantly reduced the viability of all cell lines in a manner partially dependent on MDA5.	Poly I-C	0-8	interferon induced with helicase C domain 1	Homo sapiens	112-116
22535677-2	2012	Here, we demonstrated that conventional DCs (cDCs) from C3(-/-)  and C5aR(-/-)  mice are hyperresponsive to polyI:C, a TLR3 ligand, leading to enhanced NK-cell activation.	Poly I-C	108-115	complement component 5a receptor 1	Mus musculus	69-73
22535677-2	2012	Here, we demonstrated that conventional DCs (cDCs) from C3(-/-)  and C5aR(-/-)  mice are hyperresponsive to polyI:C, a TLR3 ligand, leading to enhanced NK-cell activation.	Poly I-C	108-115	toll-like receptor 3	Mus musculus	119-123
22578853-10	2012	LPS and Poly IC induced respectively significant increases of TNF-alpha, IFN-beta, IL-6, IL-1beta, and TNF-alpha, IFN-beta, IP-10 and RANTES, both before and after exercise.	Poly I-C	8-15	tumor necrosis factor	Equus caballus	62-71
22578853-10	2012	LPS and Poly IC induced respectively significant increases of TNF-alpha, IFN-beta, IL-6, IL-1beta, and TNF-alpha, IFN-beta, IP-10 and RANTES, both before and after exercise.	Poly I-C	8-15	interferon beta	Equus caballus	73-81
22578853-10	2012	LPS and Poly IC induced respectively significant increases of TNF-alpha, IFN-beta, IL-6, IL-1beta, and TNF-alpha, IFN-beta, IP-10 and RANTES, both before and after exercise.	Poly I-C	8-15	interleukin 6	Equus caballus	83-87
22578853-10	2012	LPS and Poly IC induced respectively significant increases of TNF-alpha, IFN-beta, IL-6, IL-1beta, and TNF-alpha, IFN-beta, IP-10 and RANTES, both before and after exercise.	Poly I-C	8-15	interleukin-1 beta	Equus caballus	89-97
22578853-10	2012	LPS and Poly IC induced respectively significant increases of TNF-alpha, IFN-beta, IL-6, IL-1beta, and TNF-alpha, IFN-beta, IP-10 and RANTES, both before and after exercise.	Poly I-C	8-15	tumor necrosis factor	Equus caballus	103-112
22578853-10	2012	LPS and Poly IC induced respectively significant increases of TNF-alpha, IFN-beta, IL-6, IL-1beta, and TNF-alpha, IFN-beta, IP-10 and RANTES, both before and after exercise.	Poly I-C	8-15	interferon beta	Equus caballus	114-122
22578853-10	2012	LPS and Poly IC induced respectively significant increases of TNF-alpha, IFN-beta, IL-6, IL-1beta, and TNF-alpha, IFN-beta, IP-10 and RANTES, both before and after exercise.	Poly I-C	8-15	C-C motif chemokine 5	Equus caballus	134-140
23738203-6	2012	Descendants of poly I:C treated rats showed significant increases of 15-18% in 5HT1AR in the hippocampus (CA1) compared to controls at all developmental ages.	Poly I-C	15-23	carbonic anhydrase 1	Rattus norvegicus	106-109
22531557-10	2012	The results suggested that all of the TLR ligand treatments induced a significant reduction in virus shedding, with the TLR3 ligand poly I:C conferring the greatest AIV immunity compared to control birds, followed by CpG ODN and LPS.	Poly I-C	132-140	toll like receptor 3	Gallus gallus	120-124
22531557-11	2012	Furthermore, transcriptional analysis of gene expression in the spleen and lungs suggest IFN-alpha and IL-8 as correlates of immunity conferred by poly I:C, and IFN-gamma for CpG ODN and LPS.	Poly I-C	147-155	interferon	Gallus gallus	89-98
22531557-11	2012	Furthermore, transcriptional analysis of gene expression in the spleen and lungs suggest IFN-alpha and IL-8 as correlates of immunity conferred by poly I:C, and IFN-gamma for CpG ODN and LPS.	Poly I-C	147-155	interleukin 8-like 2	Gallus gallus	103-107
21799119-3	2012	We recently showed that a low-dose administration of polyinosinic polycytidylic acid (poly IC), a mimetic of viral dsRNA, during allergen sensitization augments airway eosinophilia and hyperresponsiveness in mice via enhanced production of IL-13 from T cells.	Poly I-C	53-84	interleukin 13	Mus musculus	240-245
22698190-2	2012	Poly (I:C) is the most potent IFN inducer.	Poly I-C	0-9	interferon alpha 1	Homo sapiens	30-33
22698190-3	2012	In in vivo mouse studies, intraperitoneal injection of Poly (I:C) elicited IFN-alpha/beta production and natural killer (NK) cells activation.	Poly I-C	55-65	interferon alpha	Mus musculus	75-84
22504646-5	2012	DCs stimulated by polyinosinic acid-polycytidylic acid or IFN-beta, another known inducer of DC apoptosis, were characterized by high levels and activation of the proapoptotic protein BAK.	Poly I-C	18-54	BCL2 antagonist/killer 1	Homo sapiens	184-187
22095092-6	2012	Using CAF01 as a backbone, we recently demonstrated that incorporating the TLR3 ligand polyinosinic/polycytidylic acid [poly(I:C)] primes CD8(+) T cells specific to the SIINFEKL epitope of the model antigen ovalbumin.	Poly I-C	87-118	toll-like receptor 3	Mus musculus	75-79
22095092-6	2012	Using CAF01 as a backbone, we recently demonstrated that incorporating the TLR3 ligand polyinosinic/polycytidylic acid [poly(I:C)] primes CD8(+) T cells specific to the SIINFEKL epitope of the model antigen ovalbumin.	Poly I-C	87-118	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	207-216
22520928-7	2012	RESULTS: PolyI:C (TLR3 ligand), FSL-1 (TLR2-TLR6 ligand) and flagellin (TLR5 ligand) upregulated long-form TSLP expression, which predominantly contributed to upregulation of total TSLP expression.	Poly I-C	9-16	toll like receptor 3	Homo sapiens	18-22
22520928-7	2012	RESULTS: PolyI:C (TLR3 ligand), FSL-1 (TLR2-TLR6 ligand) and flagellin (TLR5 ligand) upregulated long-form TSLP expression, which predominantly contributed to upregulation of total TSLP expression.	Poly I-C	9-16	toll like receptor 6	Homo sapiens	44-48
22520928-7	2012	RESULTS: PolyI:C (TLR3 ligand), FSL-1 (TLR2-TLR6 ligand) and flagellin (TLR5 ligand) upregulated long-form TSLP expression, which predominantly contributed to upregulation of total TSLP expression.	Poly I-C	9-16	thymic stromal lymphopoietin	Homo sapiens	107-111
22520928-7	2012	RESULTS: PolyI:C (TLR3 ligand), FSL-1 (TLR2-TLR6 ligand) and flagellin (TLR5 ligand) upregulated long-form TSLP expression, which predominantly contributed to upregulation of total TSLP expression.	Poly I-C	9-16	thymic stromal lymphopoietin	Homo sapiens	181-185
22520928-8	2012	A glucocorticoid or an endosomal acidification inhibitor inhibited the polyI:C-dependent upregulation of total TSLP and the decrease of the total TSLP was due to the decrease of the long-form.	Poly I-C	71-78	thymic stromal lymphopoietin	Homo sapiens	111-115
22520928-8	2012	A glucocorticoid or an endosomal acidification inhibitor inhibited the polyI:C-dependent upregulation of total TSLP and the decrease of the total TSLP was due to the decrease of the long-form.	Poly I-C	71-78	thymic stromal lymphopoietin	Homo sapiens	146-150
22516955-1	2012	Polyinosinic-polycytidylic acid (poly I:C), a TLR3 ligand, is currently being tested in human clinical trials as an adjuvant to anti-cancer vaccines and in combination with other therapies.	Poly I-C	0-31	toll like receptor 3	Homo sapiens	46-50
22514342-5	2012	Pellino-1 actions were likely to be independent of interleukin-1 receptor-associated kinase-1 (IRAK-1) regulation, since Pellino-1 knockdown in primary epithelial cells did not alter responses to IL-1 but did inhibit responses to poly(I C), a Toll-like receptor 3 (TLR3) activator that does not signal via IRAK-1 to engender a response.	Poly I-C	230-238	pellino E3 ubiquitin protein ligase 1	Homo sapiens	0-9
22491246-3	2012	In the current study, we compare the effects of the inhaled viral TLR ligands polyinosinic-polycytidylic acid (TLR3) and resiquimod (TLR7/8) on sensitization to a model allergen (OVA) in a murine model.	Poly I-C	78-109	toll-like receptor 3	Mus musculus	111-115
22491246-5	2012	Application of polyinosinic-polycytidylic acid [poly(I:C)] or LPS induces production of allergen-specific IgE and IgG1, whereas resiquimod (R848) had no effect.	Poly I-C	15-46	LOC105243590	Mus musculus	114-118
22491246-5	2012	Application of polyinosinic-polycytidylic acid [poly(I:C)] or LPS induces production of allergen-specific IgE and IgG1, whereas resiquimod (R848) had no effect.	Poly I-C	48-57	LOC105243590	Mus musculus	114-118
22491257-4	2012	These cells from C57BL/6J mice abundantly produced IL-27(p28) after engagement of either the TLR3 (polyinosinic-polycytidylic acid) or TLR4 (LPS) receptor.	Poly I-C	99-130	interleukin 27	Mus musculus	51-56
22491257-4	2012	These cells from C57BL/6J mice abundantly produced IL-27(p28) after engagement of either the TLR3 (polyinosinic-polycytidylic acid) or TLR4 (LPS) receptor.	Poly I-C	99-130	B cell receptor associated protein 31	Mus musculus	57-60
22491257-4	2012	These cells from C57BL/6J mice abundantly produced IL-27(p28) after engagement of either the TLR3 (polyinosinic-polycytidylic acid) or TLR4 (LPS) receptor.	Poly I-C	99-130	toll-like receptor 3	Mus musculus	93-97
22231731-10	2012	We found that iloprost and treprostinil induced IL-10, but suppressed TNF-alpha production in polyinosinic-polycytidylic acid (poly I:C)-stimulated mDCs.	Poly I-C	127-135	tumor necrosis factor	Homo sapiens	70-79
22538368-8	2012	In RAW cells, a macrophage cell line, LPS, zymosan, poly I:C, and imiquimod all inhibited ANGPTL4 expression.	Poly I-C	52-60	angiopoietin-like 4	Mus musculus	90-97
22038398-3	2012	In the present study, we analyzed the effects of polyinosinic-polycytidylic acid [poly(I:C)], a TLR3 ligand, on three TLR3-expressing human prostate cancer cell lines (LNCaP, PC3, and DU145).	Poly I-C	49-80	toll like receptor 3	Homo sapiens	118-122
22038398-8	2012	Additionally, poly(I:C) treatment caused dephosphorylation of Akt in LNCaP cells, but transduction of the constitutively active form of Akt rendered LNCaP cells resistant to poly(I:C).	Poly I-C	174-182	AKT serine/threonine kinase 1	Homo sapiens	136-139
22038398-3	2012	In the present study, we analyzed the effects of polyinosinic-polycytidylic acid [poly(I:C)], a TLR3 ligand, on three TLR3-expressing human prostate cancer cell lines (LNCaP, PC3, and DU145).	Poly I-C	82-91	toll like receptor 3	Homo sapiens	118-122
22038398-5	2012	Poly(I:C) significantly reduced the viability of LNCaP cells TLR3 and endosome dependently.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	61-65
22038398-8	2012	Additionally, poly(I:C) treatment caused dephosphorylation of Akt in LNCaP cells, but transduction of the constitutively active form of Akt rendered LNCaP cells resistant to poly(I:C).	Poly I-C	14-22	AKT serine/threonine kinase 1	Homo sapiens	62-65
22374413-10	2012	The results showed that the highest relative expression of LcIRF3 was in the liver at 24 h after poly I:C injection with 90 times greater than that of the non-injection group (p < 0.05).	Poly I-C	97-105	interferon regulatory factor 3	Larimichthys crocea	59-65
22374413-11	2012	Moreover, LcIRF3 transcription increased significantly at most time point in blood and spleen tissue after poly I:C stimulation compared with that of the control group.	Poly I-C	107-115	interferon regulatory factor 3	Larimichthys crocea	10-16
22530240-9	2012	Inductive expression of rNOD1 was observed following LPS and poly I:C exposure, and Aeromonas hydrophila, Edwardsiella tarda and Shigella flexneri infections.	Poly I-C	61-69	nucleotide-binding oligomerization domain containing 1	Rattus norvegicus	24-29
22374413-13	2012	In addition, LcIRF7 expression was significantly induced by poly I:C injection in spleen.	Poly I-C	60-68	interferon regulatory factor 7	Larimichthys crocea	13-19
22361747-5	2012	Poly(I:C)-stimulated NOD.Ncf1(m1J) BM-Mphi exhibited a 2- and 10-fold decrease in TNF-alpha and IFN-beta proinflammatory cytokine synthesis, respectively, in contrast to NOD BM-Mphi.	Poly I-C	0-9	neutrophil cytosolic factor 1	Mus musculus	25-29
22361747-5	2012	Poly(I:C)-stimulated NOD.Ncf1(m1J) BM-Mphi exhibited a 2- and 10-fold decrease in TNF-alpha and IFN-beta proinflammatory cytokine synthesis, respectively, in contrast to NOD BM-Mphi.	Poly I-C	0-9	tumor necrosis factor	Mus musculus	82-91
22361747-5	2012	Poly(I:C)-stimulated NOD.Ncf1(m1J) BM-Mphi exhibited a 2- and 10-fold decrease in TNF-alpha and IFN-beta proinflammatory cytokine synthesis, respectively, in contrast to NOD BM-Mphi.	Poly I-C	0-9	interferon beta 1, fibroblast	Mus musculus	96-104
22474018-9	2012	Finally, we confirmed that stimulation with IFN-gamma or TLR3 ligand (polyinosinic-polycytidylic acid) significantly induced both NK2R mRNA and surface protein expression of human PBMC-derived DCs, as well as enhanced human TAC1 mRNA, which encodes NKA and Substance P.	Poly I-C	70-101	interferon gamma	Homo sapiens	44-53
22318382-9	2012	Furthermore, caspase-1 inhibition prevented poly(I:C)-induced caspase-3/7 activation.	Poly I-C	44-53	caspase 1	Homo sapiens	13-22
22318382-9	2012	Furthermore, caspase-1 inhibition prevented poly(I:C)-induced caspase-3/7 activation.	Poly I-C	44-53	caspase 3	Homo sapiens	62-71
22474018-9	2012	Finally, we confirmed that stimulation with IFN-gamma or TLR3 ligand (polyinosinic-polycytidylic acid) significantly induced both NK2R mRNA and surface protein expression of human PBMC-derived DCs, as well as enhanced human TAC1 mRNA, which encodes NKA and Substance P.	Poly I-C	70-101	toll like receptor 3	Homo sapiens	57-61
22474018-9	2012	Finally, we confirmed that stimulation with IFN-gamma or TLR3 ligand (polyinosinic-polycytidylic acid) significantly induced both NK2R mRNA and surface protein expression of human PBMC-derived DCs, as well as enhanced human TAC1 mRNA, which encodes NKA and Substance P.	Poly I-C	70-101	tachykinin receptor 2	Homo sapiens	130-134
22474018-9	2012	Finally, we confirmed that stimulation with IFN-gamma or TLR3 ligand (polyinosinic-polycytidylic acid) significantly induced both NK2R mRNA and surface protein expression of human PBMC-derived DCs, as well as enhanced human TAC1 mRNA, which encodes NKA and Substance P.	Poly I-C	70-101	tachykinin precursor 1	Homo sapiens	224-228
22474018-9	2012	Finally, we confirmed that stimulation with IFN-gamma or TLR3 ligand (polyinosinic-polycytidylic acid) significantly induced both NK2R mRNA and surface protein expression of human PBMC-derived DCs, as well as enhanced human TAC1 mRNA, which encodes NKA and Substance P.	Poly I-C	70-101	tachykinin precursor 1	Homo sapiens	249-252
22474018-9	2012	Finally, we confirmed that stimulation with IFN-gamma or TLR3 ligand (polyinosinic-polycytidylic acid) significantly induced both NK2R mRNA and surface protein expression of human PBMC-derived DCs, as well as enhanced human TAC1 mRNA, which encodes NKA and Substance P.	Poly I-C	70-101	tachykinin precursor 1	Homo sapiens	257-268
22182524-1	2012	Viperin is an antiviral protein that is induced by different viruses, type I interferon, poly(I:C) and lipopolysaccharide, which is localized to the endoplasmic reticulum and lipid droplets.	Poly I-C	89-98	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7
22754655-9	2012	In contrast, pre-stimulation of TLR3 with polyinosinic-polycytidylic acid (poly I:C) hindered MHV infection through induction of IFN-beta in macrophages.	Poly I-C	42-73	toll-like receptor 3	Mus musculus	32-36
22754655-9	2012	In contrast, pre-stimulation of TLR3 with polyinosinic-polycytidylic acid (poly I:C) hindered MHV infection through induction of IFN-beta in macrophages.	Poly I-C	75-83	toll-like receptor 3	Mus musculus	32-36
22754655-10	2012	We demonstrate that activation of TLR3 with the synthetic ligand poly I:C mediates antiviral immunity that diminishes (MHV-A59) or suppresses (MHV-JHM, MHV-3) virus production in macrophages.	Poly I-C	65-73	toll-like receptor 3	Mus musculus	34-38
22546005-0	2012	Maternal immune activation by poly I:C induces expression of cytokines IL-1beta and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain.	Poly I-C	30-38	interleukin 1 beta	Mus musculus	71-79
22546005-0	2012	Maternal immune activation by poly I:C induces expression of cytokines IL-1beta and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain.	Poly I-C	30-38	interleukin 13	Mus musculus	84-89
22546005-0	2012	Maternal immune activation by poly I:C induces expression of cytokines IL-1beta and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain.	Poly I-C	30-38	chemokine (C-C motif) ligand 2	Mus musculus	101-106
22546005-0	2012	Maternal immune activation by poly I:C induces expression of cytokines IL-1beta and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain.	Poly I-C	30-38	vascular endothelial growth factor A	Mus musculus	137-141
22442441-3	2012	In this study, we show that macrophage activation by TLR ligands LPS and polyinosinic-polycytidylic acid induced a time-dependent increase of Sema4A and its receptors PlexinB2 and PlexinD1.	Poly I-C	73-104	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	Mus musculus	142-148
22442441-3	2012	In this study, we show that macrophage activation by TLR ligands LPS and polyinosinic-polycytidylic acid induced a time-dependent increase of Sema4A and its receptors PlexinB2 and PlexinD1.	Poly I-C	73-104	plexin B2	Mus musculus	167-175
22442441-3	2012	In this study, we show that macrophage activation by TLR ligands LPS and polyinosinic-polycytidylic acid induced a time-dependent increase of Sema4A and its receptors PlexinB2 and PlexinD1.	Poly I-C	73-104	plexin D1	Mus musculus	180-188
22187010-2	2012	We used synthetic dsRNA polyinosinic-polycytidylic acid [Poly(I:C)] as a TLR3 agonist to treat TLR3-expressing SK-N-AS neuroblatoma (NB) cells.	Poly I-C	24-55	toll like receptor 3	Homo sapiens	73-77
22262694-4	2012	The current study demonstrates that TLR3 is constitutively expressed in spermatogonia and spermatocytes and can be activated by a synthetic double-strained RNA analog, polyinosinic-polycytidylic acid.	Poly I-C	168-199	toll-like receptor 3	Mus musculus	36-40
22187010-2	2012	We used synthetic dsRNA polyinosinic-polycytidylic acid [Poly(I:C)] as a TLR3 agonist to treat TLR3-expressing SK-N-AS neuroblatoma (NB) cells.	Poly I-C	24-55	toll like receptor 3	Homo sapiens	95-99
22187010-2	2012	We used synthetic dsRNA polyinosinic-polycytidylic acid [Poly(I:C)] as a TLR3 agonist to treat TLR3-expressing SK-N-AS neuroblatoma (NB) cells.	Poly I-C	57-66	toll like receptor 3	Homo sapiens	73-77
22187010-2	2012	We used synthetic dsRNA polyinosinic-polycytidylic acid [Poly(I:C)] as a TLR3 agonist to treat TLR3-expressing SK-N-AS neuroblatoma (NB) cells.	Poly I-C	57-66	toll like receptor 3	Homo sapiens	95-99
22187010-4	2012	Bafilomycin A1, an inhibitor of ER function, effectively blocked poly(I:C)-induced activation of caspase-8, -9, and -3, MnSOD and glutathione peroxidase 1 and reduced poly(I:C)-induced SK-N-AS apoptosis.	Poly I-C	65-74	caspase 8	Homo sapiens	97-118
22187010-4	2012	Bafilomycin A1, an inhibitor of ER function, effectively blocked poly(I:C)-induced activation of caspase-8, -9, and -3, MnSOD and glutathione peroxidase 1 and reduced poly(I:C)-induced SK-N-AS apoptosis.	Poly I-C	65-74	superoxide dismutase 2	Homo sapiens	120-125
22187010-4	2012	Bafilomycin A1, an inhibitor of ER function, effectively blocked poly(I:C)-induced activation of caspase-8, -9, and -3, MnSOD and glutathione peroxidase 1 and reduced poly(I:C)-induced SK-N-AS apoptosis.	Poly I-C	65-74	glutathione peroxidase 1	Homo sapiens	130-154
22187010-4	2012	Bafilomycin A1, an inhibitor of ER function, effectively blocked poly(I:C)-induced activation of caspase-8, -9, and -3, MnSOD and glutathione peroxidase 1 and reduced poly(I:C)-induced SK-N-AS apoptosis.	Poly I-C	65-73	caspase 8	Homo sapiens	97-118
22187010-4	2012	Bafilomycin A1, an inhibitor of ER function, effectively blocked poly(I:C)-induced activation of caspase-8, -9, and -3, MnSOD and glutathione peroxidase 1 and reduced poly(I:C)-induced SK-N-AS apoptosis.	Poly I-C	65-73	superoxide dismutase 2	Homo sapiens	120-125
22187010-4	2012	Bafilomycin A1, an inhibitor of ER function, effectively blocked poly(I:C)-induced activation of caspase-8, -9, and -3, MnSOD and glutathione peroxidase 1 and reduced poly(I:C)-induced SK-N-AS apoptosis.	Poly I-C	65-73	glutathione peroxidase 1	Homo sapiens	130-154
22187010-5	2012	Pan caspase inhibitor and inhibitor of caspase-9, but not of caspase-8, inhibited poly(I:C)-induced activated caspase-3 expression.	Poly I-C	82-91	caspase 9	Homo sapiens	39-48
22187010-5	2012	Pan caspase inhibitor and inhibitor of caspase-9, but not of caspase-8, inhibited poly(I:C)-induced activated caspase-3 expression.	Poly I-C	82-91	caspase 3	Homo sapiens	110-119
22076939-10	2012	Poly(I-C) treatment diminished arthritis in IRF-7(-/-)  mice, restored synovial IFNbeta gene expression, and increased serum levels of IFNbeta.	Poly I-C	0-8	interferon regulatory factor 7	Mus musculus	44-49
22120532-2	2012	Chicken TLR3 and TLR21 (avian equivalent to mammalian TLR9) recognize poly I:C (double-stranded RNA) and CpG-ODN (a CpG-motif containing oligodeoxydinucleotide), respectively.	Poly I-C	70-78	toll like receptor 3	Gallus gallus	8-12
22076939-10	2012	Poly(I-C) treatment diminished arthritis in IRF-7(-/-)  mice, restored synovial IFNbeta gene expression, and increased serum levels of IFNbeta.	Poly I-C	0-8	interferon beta 1, fibroblast	Mus musculus	80-87
22076939-10	2012	Poly(I-C) treatment diminished arthritis in IRF-7(-/-)  mice, restored synovial IFNbeta gene expression, and increased serum levels of IFNbeta.	Poly I-C	0-8	interferon beta 1, fibroblast	Mus musculus	135-142
22076939-11	2012	In vitro studies demonstrated that poly(I-C) stimulation of fibroblast-like synoviocytes (FLS) from IRF-7(-/-)  mice resulted in increased induction of proinflammatory gene expression as compared with FLS from WT mice; however, IFNbeta expression was not significantly different.	Poly I-C	35-44	interferon regulatory factor 7	Mus musculus	100-105
22076939-11	2012	In vitro studies demonstrated that poly(I-C) stimulation of fibroblast-like synoviocytes (FLS) from IRF-7(-/-)  mice resulted in increased induction of proinflammatory gene expression as compared with FLS from WT mice; however, IFNbeta expression was not significantly different.	Poly I-C	35-44	interferon beta 1, fibroblast	Mus musculus	228-235
22076939-12	2012	In contrast, peritoneal macrophages from IRF-7(-/-)  mice showed significantly less induction of IFNbeta in response to poly(I-C) stimulation.	Poly I-C	120-129	interferon regulatory factor 7	Mus musculus	41-46
22076939-12	2012	In contrast, peritoneal macrophages from IRF-7(-/-)  mice showed significantly less induction of IFNbeta in response to poly(I-C) stimulation.	Poly I-C	120-129	interferon beta 1, fibroblast	Mus musculus	97-104
22120532-2	2012	Chicken TLR3 and TLR21 (avian equivalent to mammalian TLR9) recognize poly I:C (double-stranded RNA) and CpG-ODN (a CpG-motif containing oligodeoxydinucleotide), respectively.	Poly I-C	70-78	toll like receptor 21	Gallus gallus	17-22
22120532-2	2012	Chicken TLR3 and TLR21 (avian equivalent to mammalian TLR9) recognize poly I:C (double-stranded RNA) and CpG-ODN (a CpG-motif containing oligodeoxydinucleotide), respectively.	Poly I-C	70-78	toll like receptor 9	Homo sapiens	54-58
22120532-5	2012	The objective of the present study was to investigate the effect of the interaction between poly I:C and CpG-ODN on the mRNA expression levels of IFN-alpha and IFN-beta, Th1 cytokines IFN-gamma and IL-12, Th2 cytokine IL-4, and regulatory IL-10 in chicken monocytes.	Poly I-C	92-100	interferon	Gallus gallus	146-155
22120532-5	2012	The objective of the present study was to investigate the effect of the interaction between poly I:C and CpG-ODN on the mRNA expression levels of IFN-alpha and IFN-beta, Th1 cytokines IFN-gamma and IL-12, Th2 cytokine IL-4, and regulatory IL-10 in chicken monocytes.	Poly I-C	92-100	interferon omega 1	Gallus gallus	160-168
22120532-5	2012	The objective of the present study was to investigate the effect of the interaction between poly I:C and CpG-ODN on the mRNA expression levels of IFN-alpha and IFN-beta, Th1 cytokines IFN-gamma and IL-12, Th2 cytokine IL-4, and regulatory IL-10 in chicken monocytes.	Poly I-C	92-100	interleukin 4	Gallus gallus	218-222
22120532-5	2012	The objective of the present study was to investigate the effect of the interaction between poly I:C and CpG-ODN on the mRNA expression levels of IFN-alpha and IFN-beta, Th1 cytokines IFN-gamma and IL-12, Th2 cytokine IL-4, and regulatory IL-10 in chicken monocytes.	Poly I-C	92-100	interleukin 10	Gallus gallus	239-244
21613249-11	2012	Poly(I:C)-induced IRF7 gene expression was inhibited in the absence of TBK1, but not IKKepsilon.	Poly I-C	0-9	interferon regulatory factor 7	Homo sapiens	18-22
22198151-4	2012	Here we show that polyinosinic polycytidylic acid (poly I:C)-mediated very rapid apoptosis occurs within 1 hour in CD34(+) cells in a dose-dependent manner.	Poly I-C	18-49	CD34 molecule	Homo sapiens	115-119
22198151-6	2012	Poly I:C-LMW/LyoVec, a complex between low molecular-weight poly I:C and the transfection reagent LyoVec, which signals only through RIG-I/MDA-5, induces apoptosis of CD34(+) cells.	Poly I-C	0-8	DExD/H-box helicase 58	Homo sapiens	133-138
22198151-6	2012	Poly I:C-LMW/LyoVec, a complex between low molecular-weight poly I:C and the transfection reagent LyoVec, which signals only through RIG-I/MDA-5, induces apoptosis of CD34(+) cells.	Poly I-C	0-8	interferon induced with helicase C domain 1	Homo sapiens	139-144
22198151-6	2012	Poly I:C-LMW/LyoVec, a complex between low molecular-weight poly I:C and the transfection reagent LyoVec, which signals only through RIG-I/MDA-5, induces apoptosis of CD34(+) cells.	Poly I-C	0-8	CD34 molecule	Homo sapiens	167-171
22318141-7	2012	Our findings demonstrate that on poly(I   C)/IFN-gamma-stimulated mDC from CHB patients, the expression of costimulatory molecules was enhanced, while cytokine production was reduced.	Poly I-C	33-44	interferon gamma	Homo sapiens	45-54
22318141-7	2012	Our findings demonstrate that on poly(I   C)/IFN-gamma-stimulated mDC from CHB patients, the expression of costimulatory molecules was enhanced, while cytokine production was reduced.	Poly I-C	33-44	chemokine (C-C motif) ligand 22	Mus musculus	66-69
22318141-8	2012	In cocultures of poly(I   C)/IFN-gamma-stimulated mDC and NK cells obtained from CHB patients, reduced mDC-induced NK cell activation (i.e., CD69 expression) and IFN-gamma production compared to those in healthy individuals was observed.	Poly I-C	17-27	interferon gamma	Rattus norvegicus	29-38
22318141-8	2012	In cocultures of poly(I   C)/IFN-gamma-stimulated mDC and NK cells obtained from CHB patients, reduced mDC-induced NK cell activation (i.e., CD69 expression) and IFN-gamma production compared to those in healthy individuals was observed.	Poly I-C	17-27	chemokine (C-C motif) ligand 22	Mus musculus	50-53
22318141-8	2012	In cocultures of poly(I   C)/IFN-gamma-stimulated mDC and NK cells obtained from CHB patients, reduced mDC-induced NK cell activation (i.e., CD69 expression) and IFN-gamma production compared to those in healthy individuals was observed.	Poly I-C	17-27	chemokine (C-C motif) ligand 22	Mus musculus	103-106
22318141-8	2012	In cocultures of poly(I   C)/IFN-gamma-stimulated mDC and NK cells obtained from CHB patients, reduced mDC-induced NK cell activation (i.e., CD69 expression) and IFN-gamma production compared to those in healthy individuals was observed.	Poly I-C	17-27	CD69 molecule	Homo sapiens	141-145
22318141-8	2012	In cocultures of poly(I   C)/IFN-gamma-stimulated mDC and NK cells obtained from CHB patients, reduced mDC-induced NK cell activation (i.e., CD69 expression) and IFN-gamma production compared to those in healthy individuals was observed.	Poly I-C	17-27	interferon gamma	Homo sapiens	162-171
22310660-4	2012	Consequently, induction of cytokines interleukin-8 and beta interferon after poly(I   C) stimulation was impaired in Rb(-/-) MEF and Rb siRNA-transfected cells compared to controls.	Poly I-C	77-88	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
22310660-7	2012	Interestingly, poly(I   C) increased the Rb expression, and the poly(I   C)-induced TLR3 expression was impaired in Rb-depleted cells, suggesting the importance of Rb in TLR3 induction by poly(I   C).	Poly I-C	15-25	toll like receptor 3	Homo sapiens	170-174
22310660-7	2012	Interestingly, poly(I   C) increased the Rb expression, and the poly(I   C)-induced TLR3 expression was impaired in Rb-depleted cells, suggesting the importance of Rb in TLR3 induction by poly(I   C).	Poly I-C	15-26	toll like receptor 3	Homo sapiens	170-174
22310660-7	2012	Interestingly, poly(I   C) increased the Rb expression, and the poly(I   C)-induced TLR3 expression was impaired in Rb-depleted cells, suggesting the importance of Rb in TLR3 induction by poly(I   C).	Poly I-C	64-74	toll like receptor 3	Homo sapiens	84-88
22310660-7	2012	Interestingly, poly(I   C) increased the Rb expression, and the poly(I   C)-induced TLR3 expression was impaired in Rb-depleted cells, suggesting the importance of Rb in TLR3 induction by poly(I   C).	Poly I-C	64-74	toll like receptor 3	Homo sapiens	170-174
21613249-11	2012	Poly(I:C)-induced IRF7 gene expression was inhibited in the absence of TBK1, but not IKKepsilon.	Poly I-C	0-9	TANK binding kinase 1	Homo sapiens	71-75
22222172-0	2012	Peripheral administration of poly I:C disrupts contextual fear memory consolidation and BDNF expression in mice.	Poly I-C	29-37	brain derived neurotrophic factor	Mus musculus	88-92
23164691-4	2013	IBC suppressed iNOS expression induced by macrophage-activating lipopeptide 2-kDa, polyriboinosinic polyribocytidylic acid, or lipopolysaccharide.	Poly I-C	83-122	nitric oxide synthase 2, inducible	Mus musculus	15-19
22222172-3	2012	These results extend prior work, and suggest that a single peripheral injection of poly I:C disrupts contextual fear memory consolidation processes in adult mice, and that these deficits may potentially be mediated by diminished BDNF expression.	Poly I-C	83-91	brain derived neurotrophic factor	Mus musculus	229-233
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	interleukin 6	Homo sapiens	38-42
22345667-5	2012	Functionally, zfPIAS4a expression can be dramatically induced by the stimulation of polyinosinic-polycytidylic acid and zebrafish IFN1.	Poly I-C	84-115	protein inhibitor of activated STAT, 4a	Danio rerio	14-22
21964925-3	2012	Here, we report that poly(I:C) stimulation induces selective autophagic degradation of the TLR adaptor molecule TRIF and the signaling molecule TRAF6, which is revealed by gene silencing of the ubiquitin-editing enzyme A20.	Poly I-C	21-30	TIR domain containing adaptor molecule 1	Homo sapiens	112-116
21964925-3	2012	Here, we report that poly(I:C) stimulation induces selective autophagic degradation of the TLR adaptor molecule TRIF and the signaling molecule TRAF6, which is revealed by gene silencing of the ubiquitin-editing enzyme A20.	Poly I-C	21-30	TNF receptor associated factor 6	Homo sapiens	144-149
21964925-3	2012	Here, we report that poly(I:C) stimulation induces selective autophagic degradation of the TLR adaptor molecule TRIF and the signaling molecule TRAF6, which is revealed by gene silencing of the ubiquitin-editing enzyme A20.	Poly I-C	21-30	immunoglobulin kappa variable 1-27	Homo sapiens	219-222
21964925-8	2012	Intriguingly, only under the condition of A20 silencing, NDP52 could effectively suppress poly(I:C)-induced proinflammatory gene expression.	Poly I-C	90-99	immunoglobulin kappa variable 1-27	Homo sapiens	42-45
21964925-8	2012	Intriguingly, only under the condition of A20 silencing, NDP52 could effectively suppress poly(I:C)-induced proinflammatory gene expression.	Poly I-C	90-99	calcium binding and coiled-coil domain 2	Homo sapiens	57-62
21567398-4	2012	The TLR3 agonist polyinosinic-polycytidylic acid also induced rapid degranulation, whereas the TLR4 and TLR5 agonists LPS and flagellin, respectively, induced late degranulation mediated by TNF-alpha.	Poly I-C	17-48	toll-like receptor 3	Mus musculus	4-8
22221924-4	2012	Mouse hepatitis virus type 3 (MHV-3) and polyinosinic-polycytidylic acid [poly(I:C)] were used to stimulate the activation of IFN-beta.	Poly I-C	41-72	interferon beta 1, fibroblast	Mus musculus	126-134
22221924-4	2012	Mouse hepatitis virus type 3 (MHV-3) and polyinosinic-polycytidylic acid [poly(I:C)] were used to stimulate the activation of IFN-beta.	Poly I-C	74-83	interferon beta 1, fibroblast	Mus musculus	126-134
22070917-9	2012	The stimulation of TLR3-expressing OC2 cells with poly I:C caused the phosphorylation of IFN regulatory factor 3 and IkappaB and sequentially induced the secretion of interleukin-6 and chemokine (C-C motif) ligand 5 (CCL5) in a dose- and time-dependent manner.	Poly I-C	50-58	toll like receptor 3	Homo sapiens	19-23
22070917-9	2012	The stimulation of TLR3-expressing OC2 cells with poly I:C caused the phosphorylation of IFN regulatory factor 3 and IkappaB and sequentially induced the secretion of interleukin-6 and chemokine (C-C motif) ligand 5 (CCL5) in a dose- and time-dependent manner.	Poly I-C	50-58	one cut homeobox 2	Homo sapiens	35-38
22070917-9	2012	The stimulation of TLR3-expressing OC2 cells with poly I:C caused the phosphorylation of IFN regulatory factor 3 and IkappaB and sequentially induced the secretion of interleukin-6 and chemokine (C-C motif) ligand 5 (CCL5) in a dose- and time-dependent manner.	Poly I-C	50-58	interleukin 6	Homo sapiens	167-215
22070917-9	2012	The stimulation of TLR3-expressing OC2 cells with poly I:C caused the phosphorylation of IFN regulatory factor 3 and IkappaB and sequentially induced the secretion of interleukin-6 and chemokine (C-C motif) ligand 5 (CCL5) in a dose- and time-dependent manner.	Poly I-C	50-58	C-C motif chemokine ligand 5	Homo sapiens	217-221
22070917-10	2012	Moreover, poly I:C stimulation promoted CCL5-mediated migration in OC2 cells.	Poly I-C	10-18	C-C motif chemokine ligand 5	Homo sapiens	40-44
22070917-10	2012	Moreover, poly I:C stimulation promoted CCL5-mediated migration in OC2 cells.	Poly I-C	10-18	one cut homeobox 2	Homo sapiens	67-70
22308357-2	2012	PolyI:C, a dsRNA analog, is reported to induce inflammation and potent antitumor immune responses via the Toll-like receptor 3/Toll-IL-1 receptor domain-containing adaptor molecule 1 (TICAM-1) and melanoma differentiation-associated protein 5/IFN-beta promoter stimulator 1 (IPS-1) pathways in mDCs to drive activation of natural killer cells and cytotoxic T lymphocytes.	Poly I-C	0-7	toll-like receptor adaptor molecule 1	Mus musculus	125-182
22308357-2	2012	PolyI:C, a dsRNA analog, is reported to induce inflammation and potent antitumor immune responses via the Toll-like receptor 3/Toll-IL-1 receptor domain-containing adaptor molecule 1 (TICAM-1) and melanoma differentiation-associated protein 5/IFN-beta promoter stimulator 1 (IPS-1) pathways in mDCs to drive activation of natural killer cells and cytotoxic T lymphocytes.	Poly I-C	0-7	toll-like receptor adaptor molecule 1	Mus musculus	184-191
22308357-2	2012	PolyI:C, a dsRNA analog, is reported to induce inflammation and potent antitumor immune responses via the Toll-like receptor 3/Toll-IL-1 receptor domain-containing adaptor molecule 1 (TICAM-1) and melanoma differentiation-associated protein 5/IFN-beta promoter stimulator 1 (IPS-1) pathways in mDCs to drive activation of natural killer cells and cytotoxic T lymphocytes.	Poly I-C	0-7	interferon induced with helicase C domain 1	Mus musculus	197-273
22308357-2	2012	PolyI:C, a dsRNA analog, is reported to induce inflammation and potent antitumor immune responses via the Toll-like receptor 3/Toll-IL-1 receptor domain-containing adaptor molecule 1 (TICAM-1) and melanoma differentiation-associated protein 5/IFN-beta promoter stimulator 1 (IPS-1) pathways in mDCs to drive activation of natural killer cells and cytotoxic T lymphocytes.	Poly I-C	0-7	mitochondrial antiviral signaling protein	Mus musculus	275-280
22308357-6	2012	TNF-alpha was increased within 1 h in both tumor and serum upon polyI:C injection into tumor-bearing mice, followed by tumor hemorrhagic necrosis and growth suppression.	Poly I-C	64-71	tumor necrosis factor	Mus musculus	0-9
22308357-8	2012	Furthermore, F4/80(+) Mfs in tumors extracted from polyI:C-injected mice sustained Lewis lung carcinoma cytotoxic activity, and this activity was partly abrogated by anti-TNF-alpha Ab.	Poly I-C	51-58	tumor necrosis factor	Mus musculus	171-180
22119586-6	2012	Moreover, poly(I:C) increased the level of IFN-gamma, a Th1 cytokine, whereas decreasing that of selective Th2 cytokine both in vivo and in vitro.	Poly I-C	10-18	interferon gamma	Mus musculus	43-52
22119586-6	2012	Moreover, poly(I:C) increased the level of IFN-gamma, a Th1 cytokine, whereas decreasing that of selective Th2 cytokine both in vivo and in vitro.	Poly I-C	10-18	negative elongation factor complex member C/D, Th1l	Mus musculus	56-59
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	C-C motif chemokine ligand 2	Homo sapiens	50-55
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	C-C motif chemokine ligand 5	Homo sapiens	57-63
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	C-X-C motif chemokine ligand 10	Homo sapiens	65-70
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	C-C motif chemokine ligand 11	Homo sapiens	72-79
22119586-6	2012	Moreover, poly(I:C) increased the level of IFN-gamma, a Th1 cytokine, whereas decreasing that of selective Th2 cytokine both in vivo and in vitro.	Poly I-C	10-18	heart and neural crest derivatives expressed 2	Mus musculus	107-110
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	C-C motif chemokine ligand 4	Homo sapiens	81-90
22119586-8	2012	These results suggest that poly(I:C) inhibit the development of Df-induced AD-like skin lesions in NC/Nga mice through regulation of the Th1/Th2 balance.	Poly I-C	27-35	negative elongation factor complex member C/D, Th1l	Mus musculus	137-140
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	interferon gamma	Homo sapiens	96-112
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	interleukin 6	Homo sapiens	158-162
22119586-8	2012	These results suggest that poly(I:C) inhibit the development of Df-induced AD-like skin lesions in NC/Nga mice through regulation of the Th1/Th2 balance.	Poly I-C	27-35	heart and neural crest derivatives expressed 2	Mus musculus	141-144
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	C-C motif chemokine ligand 2	Homo sapiens	174-179
22116002-7	2012	LPS, poly(I:C), and zymosan thus each induced a distinct pattern of cytokine and chemokine release from human corneal fibroblasts, with the release of IL-6, IL-8, and MCP-1 being commonly elicited by all three agents.	Poly I-C	5-14	interleukin 6	Homo sapiens	151-155
22116002-7	2012	LPS, poly(I:C), and zymosan thus each induced a distinct pattern of cytokine and chemokine release from human corneal fibroblasts, with the release of IL-6, IL-8, and MCP-1 being commonly elicited by all three agents.	Poly I-C	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
22116002-7	2012	LPS, poly(I:C), and zymosan thus each induced a distinct pattern of cytokine and chemokine release from human corneal fibroblasts, with the release of IL-6, IL-8, and MCP-1 being commonly elicited by all three agents.	Poly I-C	5-14	C-C motif chemokine ligand 2	Homo sapiens	167-172
22154513-0	2012	CpG-DNA suppresses poly(I:C)-induced TSLP production in human laryngeal arytenoid fibroblasts.	Poly I-C	19-28	thymic stromal lymphopoietin	Homo sapiens	37-41
22154513-5	2012	TSLP production by arytenoid fibroblasts was strongly induced in the presence of polyinosinic-polycytidylic acid (poly(I:C)), a ligand of TLR3.	Poly I-C	81-112	thymic stromal lymphopoietin	Homo sapiens	0-4
22154513-5	2012	TSLP production by arytenoid fibroblasts was strongly induced in the presence of polyinosinic-polycytidylic acid (poly(I:C)), a ligand of TLR3.	Poly I-C	81-112	toll like receptor 3	Homo sapiens	138-142
22154513-5	2012	TSLP production by arytenoid fibroblasts was strongly induced in the presence of polyinosinic-polycytidylic acid (poly(I:C)), a ligand of TLR3.	Poly I-C	114-123	thymic stromal lymphopoietin	Homo sapiens	0-4
22154513-5	2012	TSLP production by arytenoid fibroblasts was strongly induced in the presence of polyinosinic-polycytidylic acid (poly(I:C)), a ligand of TLR3.	Poly I-C	114-123	toll like receptor 3	Homo sapiens	138-142
22154513-7	2012	We also revealed that B type DNA containing CpG motifs (CpG-DNA) coding for a TLR9 ligand markedly suppressed both poly(I:C)-induced and poly(I:C)-plus-IL-4-induced TSLP production.	Poly I-C	115-123	toll like receptor 9	Homo sapiens	78-82
22285102-7	2012	The effect of Poly (I:C) was reversed by Stuarosporine (1 muM), GO6983 (7 muM), Bisindolylmaleimide (1 muM) [a protein inhibitor (PKC)], and SB 203580 (3 muM) (a p38-MAPK inhibitor).	Poly I-C	14-23	latexin	Homo sapiens	58-61
22285102-7	2012	The effect of Poly (I:C) was reversed by Stuarosporine (1 muM), GO6983 (7 muM), Bisindolylmaleimide (1 muM) [a protein inhibitor (PKC)], and SB 203580 (3 muM) (a p38-MAPK inhibitor).	Poly I-C	14-23	latexin	Homo sapiens	74-77
22285102-7	2012	The effect of Poly (I:C) was reversed by Stuarosporine (1 muM), GO6983 (7 muM), Bisindolylmaleimide (1 muM) [a protein inhibitor (PKC)], and SB 203580 (3 muM) (a p38-MAPK inhibitor).	Poly I-C	14-23	latexin	Homo sapiens	74-77
22285102-7	2012	The effect of Poly (I:C) was reversed by Stuarosporine (1 muM), GO6983 (7 muM), Bisindolylmaleimide (1 muM) [a protein inhibitor (PKC)], and SB 203580 (3 muM) (a p38-MAPK inhibitor).	Poly I-C	14-23	latexin	Homo sapiens	74-77
22285102-7	2012	The effect of Poly (I:C) was reversed by Stuarosporine (1 muM), GO6983 (7 muM), Bisindolylmaleimide (1 muM) [a protein inhibitor (PKC)], and SB 203580 (3 muM) (a p38-MAPK inhibitor).	Poly I-C	14-23	mitogen-activated protein kinase 14	Homo sapiens	162-170
22082188-3	2012	PolyI:C was a potent inducer of proinflammatory cytokines, and both these responses and the cytotoxic effects were found to be TLR3 dependent, as demonstrated by the use of siRNA for TLR3.	Poly I-C	0-7	toll like receptor 3	Homo sapiens	127-131
21767564-9	2012	In response to PGN and LTA stimulation, Aeromonas hydrophila and Edwardsiella tarda infection, and poly I:C treatment, expression of rNOD-2 and its associated downstream molecules RICK and IFN-gamma were significantly enhanced in the treated fish compared to control.	Poly I-C	99-107	nucleotide-binding oligomerization domain containing 2	Rattus norvegicus	133-139
22082188-3	2012	PolyI:C was a potent inducer of proinflammatory cytokines, and both these responses and the cytotoxic effects were found to be TLR3 dependent, as demonstrated by the use of siRNA for TLR3.	Poly I-C	0-7	toll like receptor 3	Homo sapiens	183-187
22082188-6	2012	We have found polyI:C induced cytotoxicity and proinflammatory responses to be dependent of TLR3 and that this may be inhibited by ODNs.	Poly I-C	14-21	toll like receptor 3	Homo sapiens	92-96
21617192-5	2012	Based on high expression of TLR3, we evaluated the effect of polyinosinic-polycytidylic acid (polyIC), a TLR3 ligand, to induce CD80 expression in vitro.	Poly I-C	61-92	toll like receptor 3	Homo sapiens	105-109
21929369-4	2012	The TLR7 ligand poly-C inhibited low-path influenza A growth in the chicken macrophage cell line HD-11 more effectively than poly(I:C), which acts via TLR3.	Poly I-C	125-133	toll like receptor 3	Gallus gallus	151-155
21617192-5	2012	Based on high expression of TLR3, we evaluated the effect of polyinosinic-polycytidylic acid (polyIC), a TLR3 ligand, to induce CD80 expression in vitro.	Poly I-C	61-92	CD80 molecule	Homo sapiens	128-132
21617192-5	2012	Based on high expression of TLR3, we evaluated the effect of polyinosinic-polycytidylic acid (polyIC), a TLR3 ligand, to induce CD80 expression in vitro.	Poly I-C	94-100	toll like receptor 3	Homo sapiens	105-109
21617192-5	2012	Based on high expression of TLR3, we evaluated the effect of polyinosinic-polycytidylic acid (polyIC), a TLR3 ligand, to induce CD80 expression in vitro.	Poly I-C	94-100	CD80 molecule	Homo sapiens	128-132
21617192-7	2012	Among TLR ligands 1-9, CD80 mRNA expression was significantly induced by polyIC and lipopolysaccharide (TLR4 ligand) with the greatest stimulation by polyIC (6.8 +- 0.7 times at 6 h, P < 0.001 versus control).	Poly I-C	73-79	CD80 molecule	Homo sapiens	23-27
21617192-8	2012	PolyIC induced increased expression of Cathepsin L, decreased synaptopodin expression and resulted in actin reorganization which suggested a similar injury pattern as observed with lipopolyssaccharide.	Poly I-C	0-6	cathepsin L	Homo sapiens	39-50
23028806-4	2012	Here, we report that MAVS mRNA is degraded in response to polyinosinic-polycytidylic acid (polyI:C), a synthetic dsRNA, in A549 cells.	Poly I-C	58-89	mitochondrial antiviral signaling protein	Homo sapiens	21-25
23028806-4	2012	Here, we report that MAVS mRNA is degraded in response to polyinosinic-polycytidylic acid (polyI:C), a synthetic dsRNA, in A549 cells.	Poly I-C	91-98	mitochondrial antiviral signaling protein	Homo sapiens	21-25
23028806-7	2012	In the resting state, the MAVS protein was protected from degradation by interferon regulatory factor 3 (IRF3); moreover, the dimerization of IRF3 appeared to be correlated with the rescue of protein degradation in response to polyI:C.	Poly I-C	227-234	mitochondrial antiviral signaling protein	Homo sapiens	26-30
23028806-7	2012	In the resting state, the MAVS protein was protected from degradation by interferon regulatory factor 3 (IRF3); moreover, the dimerization of IRF3 appeared to be correlated with the rescue of protein degradation in response to polyI:C.	Poly I-C	227-234	interferon regulatory factor 3	Homo sapiens	142-146
23028806-8	2012	The overexpression of MAVS enhanced interferon-beta (IFN-beta) expression in response to polyI:C, suggesting that the degradation of MAVS contributes to the suppression of the hyper-immune reaction in late-phase antiviral signaling.	Poly I-C	89-96	mitochondrial antiviral signaling protein	Homo sapiens	22-26
23028806-8	2012	The overexpression of MAVS enhanced interferon-beta (IFN-beta) expression in response to polyI:C, suggesting that the degradation of MAVS contributes to the suppression of the hyper-immune reaction in late-phase antiviral signaling.	Poly I-C	89-96	interferon beta 1	Homo sapiens	36-51
23028806-8	2012	The overexpression of MAVS enhanced interferon-beta (IFN-beta) expression in response to polyI:C, suggesting that the degradation of MAVS contributes to the suppression of the hyper-immune reaction in late-phase antiviral signaling.	Poly I-C	89-96	interferon beta 1	Homo sapiens	53-61
23028806-8	2012	The overexpression of MAVS enhanced interferon-beta (IFN-beta) expression in response to polyI:C, suggesting that the degradation of MAVS contributes to the suppression of the hyper-immune reaction in late-phase antiviral signaling.	Poly I-C	89-96	mitochondrial antiviral signaling protein	Homo sapiens	133-137
22911825-6	2012	Simvastatin impaired poly (I:C)-induced IFN-alpha expression in macrophages or dendritic cells, possibly due to lowered toll-like receptor (TLR) 3 expression; however, the mechanisms were not related to interferon regulatory factor 3 or nuclear factor kappa B signaling pathway.	Poly I-C	21-31	interferon-alpha-14	Sus scrofa	40-49
22319556-5	2012	Inhibition of protein synthesis by cycloheximide revealed that poly I:C- or LPS-induced secreted TNF-alpha is synthesized de novo, not released from cellular stores.	Poly I-C	63-71	tumor necrosis factor	Homo sapiens	97-106
22590509-5	2012	Transfection with polyinosinic-polycytidylic acid (poly(I:C)) and 5"-triphosphate RNA were used to activate the cytoplasmic double-stranded (ds)RNA sensors melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I).	Poly I-C	18-49	interferon induced with helicase C domain 1	Homo sapiens	156-198
22590509-5	2012	Transfection with polyinosinic-polycytidylic acid (poly(I:C)) and 5"-triphosphate RNA were used to activate the cytoplasmic double-stranded (ds)RNA sensors melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I).	Poly I-C	18-49	interferon induced with helicase C domain 1	Homo sapiens	200-204
22590509-5	2012	Transfection with polyinosinic-polycytidylic acid (poly(I:C)) and 5"-triphosphate RNA were used to activate the cytoplasmic double-stranded (ds)RNA sensors melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I).	Poly I-C	18-49	DExD/H-box helicase 58	Homo sapiens	210-240
22590509-5	2012	Transfection with polyinosinic-polycytidylic acid (poly(I:C)) and 5"-triphosphate RNA were used to activate the cytoplasmic double-stranded (ds)RNA sensors melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I).	Poly I-C	18-49	DExD/H-box helicase 58	Homo sapiens	242-247
22629344-2	2012	To explore the role of the interaction between NK cells and macrophages in the regulation of anti-tumor activities of NK cells, we here demonstrate that poly I:C-treated macrophages increased NK cell-mediated cytotoxicity against target tumor cells in NKG2D-dependent manner.	Poly I-C	153-161	killer cell lectin like receptor K1	Homo sapiens	252-257
22629344-3	2012	In addition, IL-15, IL-18, and IFN-beta secreted by poly I:C-treated macrophages are also involved in NKG2D expression and NK cell activation.	Poly I-C	52-60	interleukin 15	Homo sapiens	13-18
22629344-3	2012	In addition, IL-15, IL-18, and IFN-beta secreted by poly I:C-treated macrophages are also involved in NKG2D expression and NK cell activation.	Poly I-C	52-60	interleukin 18	Homo sapiens	20-25
22629344-3	2012	In addition, IL-15, IL-18, and IFN-beta secreted by poly I:C-treated macrophages are also involved in NKG2D expression and NK cell activation.	Poly I-C	52-60	interferon beta 1	Homo sapiens	31-39
22629344-3	2012	In addition, IL-15, IL-18, and IFN-beta secreted by poly I:C-treated macrophages are also involved in NKG2D expression and NK cell activation.	Poly I-C	52-60	killer cell lectin like receptor K1	Homo sapiens	102-107
22319556-6	2012	Using real time RT-PCR, we found inhibition of LPS and poly I:C induced TNF-alpha gene transcription by ethanol.	Poly I-C	55-63	tumor necrosis factor	Homo sapiens	72-81
22319556-11	2012	In contrast, cells treated with poly I:C had decreased secretion of TNF-alpha but not cell surface expression.	Poly I-C	32-40	tumor necrosis factor	Homo sapiens	68-77
22319575-5	2012	Using intraperitoneal administration of the toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly(I:C)), we induced rapid TG2 activation in the mouse small intestine.	Poly I-C	80-111	toll-like receptor 3	Mus musculus	44-64
22319575-5	2012	Using intraperitoneal administration of the toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly(I:C)), we induced rapid TG2 activation in the mouse small intestine.	Poly I-C	80-111	toll-like receptor 3	Mus musculus	66-70
22319575-5	2012	Using intraperitoneal administration of the toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly(I:C)), we induced rapid TG2 activation in the mouse small intestine.	Poly I-C	80-111	transglutaminase 2, C polypeptide	Mus musculus	142-145
22319575-5	2012	Using intraperitoneal administration of the toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly(I:C)), we induced rapid TG2 activation in the mouse small intestine.	Poly I-C	113-122	toll-like receptor 3	Mus musculus	44-64
22319575-5	2012	Using intraperitoneal administration of the toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly(I:C)), we induced rapid TG2 activation in the mouse small intestine.	Poly I-C	113-122	toll-like receptor 3	Mus musculus	66-70
22319575-5	2012	Using intraperitoneal administration of the toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly(I:C)), we induced rapid TG2 activation in the mouse small intestine.	Poly I-C	113-122	transglutaminase 2, C polypeptide	Mus musculus	142-145
21952237-4	2011	Using a human trophoblast cell culture system, we studied the effect of TLR-3 ligation on IDO expression and function by treating trophoblasts with polyinosinic-polycytidylic acid [poly(I:C)] (a synthetic double stranded RNA, which mimics viral RNA).	Poly I-C	148-179	toll like receptor 3	Homo sapiens	72-77
22208359-10	2011	pAkt was critical in LPS- or PIC-induced production of IL-10 and IL-1ra.	Poly I-C	29-32	interleukin 10	Homo sapiens	55-60
22208359-10	2011	pAkt was critical in LPS- or PIC-induced production of IL-10 and IL-1ra.	Poly I-C	29-32	interleukin 1 receptor antagonist	Homo sapiens	65-71
21979902-0	2011	Endothelin-1 production upon polyI:C stimulation of human conjunctival epithelium.	Poly I-C	29-36	endothelin 1	Homo sapiens	0-12
21926109-4	2011	Although, TRIF-mediated signal inducers, lipopolysaccharide or poly (I:C), induced high level of extracellular signal-regulated kinase (ERK)-1/2 mitogen-activated protein kinase (MAPK) phosphorylation, but they were failed to induce significant p38MAPK phosphorylation in TAM.	Poly I-C	63-72	TIR domain containing adaptor molecule 1	Homo sapiens	10-14
21926109-4	2011	Although, TRIF-mediated signal inducers, lipopolysaccharide or poly (I:C), induced high level of extracellular signal-regulated kinase (ERK)-1/2 mitogen-activated protein kinase (MAPK) phosphorylation, but they were failed to induce significant p38MAPK phosphorylation in TAM.	Poly I-C	63-72	mitogen-activated protein kinase 3	Homo sapiens	97-144
21926109-4	2011	Although, TRIF-mediated signal inducers, lipopolysaccharide or poly (I:C), induced high level of extracellular signal-regulated kinase (ERK)-1/2 mitogen-activated protein kinase (MAPK) phosphorylation, but they were failed to induce significant p38MAPK phosphorylation in TAM.	Poly I-C	63-72	mitogen-activated protein kinase 3	Homo sapiens	179-183
22015147-3	2011	The expression of BLyS mRNA by tonsillar fibroblasts was strongly induced in the presence of polyinosinic-polycytidylic acid (poly(I:C)) that is a ligand, of TLR3.	Poly I-C	93-124	TNF superfamily member 13b	Homo sapiens	18-22
22015147-3	2011	The expression of BLyS mRNA by tonsillar fibroblasts was strongly induced in the presence of polyinosinic-polycytidylic acid (poly(I:C)) that is a ligand, of TLR3.	Poly I-C	93-124	toll like receptor 3	Homo sapiens	158-162
22015147-3	2011	The expression of BLyS mRNA by tonsillar fibroblasts was strongly induced in the presence of polyinosinic-polycytidylic acid (poly(I:C)) that is a ligand, of TLR3.	Poly I-C	126-135	TNF superfamily member 13b	Homo sapiens	18-22
22015147-3	2011	The expression of BLyS mRNA by tonsillar fibroblasts was strongly induced in the presence of polyinosinic-polycytidylic acid (poly(I:C)) that is a ligand, of TLR3.	Poly I-C	126-135	toll like receptor 3	Homo sapiens	158-162
22015147-6	2011	Pre-incubation with nuclear factor kappa B (NF-kappaB) signaling inhibitors reduced the poly(I:C)-induced BLyS-expression.	Poly I-C	88-97	nuclear factor kappa B subunit 1	Homo sapiens	20-42
22015147-6	2011	Pre-incubation with nuclear factor kappa B (NF-kappaB) signaling inhibitors reduced the poly(I:C)-induced BLyS-expression.	Poly I-C	88-97	nuclear factor kappa B subunit 1	Homo sapiens	44-53
22015147-6	2011	Pre-incubation with nuclear factor kappa B (NF-kappaB) signaling inhibitors reduced the poly(I:C)-induced BLyS-expression.	Poly I-C	88-97	TNF superfamily member 13b	Homo sapiens	106-110
21952237-4	2011	Using a human trophoblast cell culture system, we studied the effect of TLR-3 ligation on IDO expression and function by treating trophoblasts with polyinosinic-polycytidylic acid [poly(I:C)] (a synthetic double stranded RNA, which mimics viral RNA).	Poly I-C	148-179	indoleamine 2,3-dioxygenase 1	Homo sapiens	90-93
21952237-4	2011	Using a human trophoblast cell culture system, we studied the effect of TLR-3 ligation on IDO expression and function by treating trophoblasts with polyinosinic-polycytidylic acid [poly(I:C)] (a synthetic double stranded RNA, which mimics viral RNA).	Poly I-C	181-190	toll like receptor 3	Homo sapiens	72-77
21964048-7	2011	Further studies indicated that IL-1beta was involved in TLR3-induced cell proliferation inhibition, as IL-1beta inhibited cell proliferation in a dose-dependent manner, and the IL-1beta receptor type I (IL-1R1)-neutralizing antibody ameliorated Poly I:C-induced cell proliferation inhibition.	Poly I-C	245-253	interleukin 1 receptor type 1	Homo sapiens	203-209
21964048-8	2011	Taken together, these results suggest that Poly I:C impairs cell proliferation by inducing cell cycle progress inhibition and cell apoptosis via TLR3 in EPCs.	Poly I-C	43-51	toll like receptor 3	Homo sapiens	145-149
21964048-7	2011	Further studies indicated that IL-1beta was involved in TLR3-induced cell proliferation inhibition, as IL-1beta inhibited cell proliferation in a dose-dependent manner, and the IL-1beta receptor type I (IL-1R1)-neutralizing antibody ameliorated Poly I:C-induced cell proliferation inhibition.	Poly I-C	245-253	interleukin 1 beta	Homo sapiens	31-39
21964048-7	2011	Further studies indicated that IL-1beta was involved in TLR3-induced cell proliferation inhibition, as IL-1beta inhibited cell proliferation in a dose-dependent manner, and the IL-1beta receptor type I (IL-1R1)-neutralizing antibody ameliorated Poly I:C-induced cell proliferation inhibition.	Poly I-C	245-253	toll like receptor 3	Homo sapiens	56-60
22093032-6	2011	These cells respond to both Poly(I:C) and LPS, by up-regulating expression of CD86.	Poly I-C	28-37	CD86 molecule	Homo sapiens	78-82
22136495-11	2011	In addition, megakaryocytes increased IFN-I transcript levels and produced IFN-beta upon stimulation with PolyI:C, a synthetic dsRNA that mimics viral infection.	Poly I-C	106-113	interferon beta 1	Homo sapiens	75-83
21996340-9	2011	PolyI:C induced protein kinase D (PKD) phosphorylation, and a PKD antagonist attenuated polyI:C-induced disassembly of apical junctions and barrier dysfunction.	Poly I-C	0-7	protein kinase D1	Homo sapiens	16-32
21996340-9	2011	PolyI:C induced protein kinase D (PKD) phosphorylation, and a PKD antagonist attenuated polyI:C-induced disassembly of apical junctions and barrier dysfunction.	Poly I-C	0-7	protein kinase D1	Homo sapiens	34-37
21996340-9	2011	PolyI:C induced protein kinase D (PKD) phosphorylation, and a PKD antagonist attenuated polyI:C-induced disassembly of apical junctions and barrier dysfunction.	Poly I-C	88-95	protein kinase D1	Homo sapiens	62-65
21996340-11	2011	PolyI:C-dependent barrier disruption is mediated by disassembly of epithelial apical junctions, which is dependent on PKD signaling.	Poly I-C	0-7	protein kinase D1	Homo sapiens	118-121
22048772-6	2011	Polyinosinic-polycytidylic acid (poly(I:C)), an analog of viral dsRNA, is recognized by TLR3 and is currently in preclinical trials as an inducer of type I IFN.	Poly I-C	0-31	toll like receptor 3	Homo sapiens	88-92
22048772-6	2011	Polyinosinic-polycytidylic acid (poly(I:C)), an analog of viral dsRNA, is recognized by TLR3 and is currently in preclinical trials as an inducer of type I IFN.	Poly I-C	33-42	toll like receptor 3	Homo sapiens	88-92
21945963-0	2011	Efficient induction of anti-tumor immunity by a TAT-CEA fusion protein vaccine with poly(I:C) in a murine colorectal tumor model.	Poly I-C	84-92	carcinoembryonic antigen gene family	Mus musculus	52-55
21835207-0	2011	Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment.	Poly I-C	116-123	DISC1 scaffold protein	Homo sapiens	80-85
21967896-5	2011	Young CD28(-/-) NOD mice were injected with polyinosinic-polycytidylic acid to activate innate immunity in an effort to induce diabetes onset.	Poly I-C	44-75	CD28 antigen	Mus musculus	6-10
21967896-7	2011	Eighty-three percent of CD28(-/-) NOD mice developed diabetes within 1-6 d after injection of polyinosinic-polycytidylic acid.	Poly I-C	94-125	CD28 antigen	Mus musculus	24-28
21744070-4	2011	In our study, bone marrow precursor cells cultures in GM-CSF and IL-4 were treated with poly(I:C) through the culture, Gr1(+)CD11b(+) cells with MDSC functions, such as NO release and T cell suppression were accumulated in the culture system.	Poly I-C	88-96	colony stimulating factor 2	Homo sapiens	54-60
21744070-4	2011	In our study, bone marrow precursor cells cultures in GM-CSF and IL-4 were treated with poly(I:C) through the culture, Gr1(+)CD11b(+) cells with MDSC functions, such as NO release and T cell suppression were accumulated in the culture system.	Poly I-C	88-96	interleukin 4	Homo sapiens	65-69
21744070-4	2011	In our study, bone marrow precursor cells cultures in GM-CSF and IL-4 were treated with poly(I:C) through the culture, Gr1(+)CD11b(+) cells with MDSC functions, such as NO release and T cell suppression were accumulated in the culture system.	Poly I-C	88-96	integrin subunit alpha M	Homo sapiens	125-130
22056942-10	2011	MULAN expression remained increased 24h post-stimulation with both LPS and IL-1beta, but was down regulated by PolyI:C at this time.	Poly I-C	111-118	mitochondrial ubiquitin ligase activator of NF-kB	Salmo salar	0-5
21945963-11	2011	Taken together, these results suggest that poly(I:C) could be used as a potent adjuvant to induce the anti-tumor immunity of a TAT-CEA fusion protein vaccine in a murine colorectal tumor model.	Poly I-C	43-52	carcinoembryonic antigen gene family	Mus musculus	131-134
21691724-0	2011	Poly(I:C)-induced tumour cell death leads to DC maturation and Th1 activation.	Poly I-C	0-9	negative elongation factor complex member C/D	Homo sapiens	63-66
21745520-2	2011	In the present study, we aimed to evaluate the immune responses of peptide-specific CD8(+) T cells induced by HLA-A*0201 restricted severe acute respiratory syndrome-associated coronavirus (SARS-CoV) S epitopes plus CpG oligodeoxynucleotide (CpG ODN), PolyI:C and R848 as adjuvants.	Poly I-C	252-259	CD8a molecule	Homo sapiens	84-87
22256608-9	2011	Our findings suggest that polyI:C-treated DN-DISC1 mice are a validated animal model for schizophrenia with gene-environment interactions.	Poly I-C	26-33	disrupted in schizophrenia 1	Mus musculus	42-50
21911422-5	2011	This patient is compound heterozygous for two loss-of-function TLR3 alleles, resulting in an absence of response to TLR3 activation by polyinosinic-polycytidylic acid (poly(I:C)) and related agonists in his fibroblasts.	Poly I-C	135-166	toll like receptor 3	Homo sapiens	63-67
21911422-5	2011	This patient is compound heterozygous for two loss-of-function TLR3 alleles, resulting in an absence of response to TLR3 activation by polyinosinic-polycytidylic acid (poly(I:C)) and related agonists in his fibroblasts.	Poly I-C	135-166	toll like receptor 3	Homo sapiens	116-120
21691724-4	2011	We show that uptake of poly(I:C)-induced apoptotic tumour cells leads to DC maturation and activation with a Th1 cell polarising capacity.	Poly I-C	23-32	negative elongation factor complex member C/D	Homo sapiens	109-112
21994002-5	2011	Poly (I:C)-induced expression of platelet-activating factor receptor (PAF-R) was assayed using real-time polymerase chain reaction, flow cytometry, and immunofluorescence microscopy.	Poly I-C	0-9	platelet activating factor receptor	Homo sapiens	70-75
22256608-8	2011	In this review, we show how gene-environment interactions during neurodevelopment result in phenotypic changes in adulthood, by injecting polyI:C into transgenic mice that express a dominant-negative form of human DISC1 (DN-DISC1).	Poly I-C	138-145	DISC1 scaffold protein	Homo sapiens	214-219
22256608-8	2011	In this review, we show how gene-environment interactions during neurodevelopment result in phenotypic changes in adulthood, by injecting polyI:C into transgenic mice that express a dominant-negative form of human DISC1 (DN-DISC1).	Poly I-C	138-145	DISC1 scaffold protein	Homo sapiens	221-229
21910728-5	2011	Data from human and autoimmune murine models suggest that environmental and/or infectious agents can exacerbate autoimmune reactions, and a model of PBC has been described in which polyinosinic-polycytidylic acid (poly I:C), a viral RNA mimetic and Toll-like receptor 3 (TLR-3) agonist induces low-titre AMAs and in mild portal infiltrates.	Poly I-C	181-212	toll-like receptor 3	Mus musculus	249-269
21910728-5	2011	Data from human and autoimmune murine models suggest that environmental and/or infectious agents can exacerbate autoimmune reactions, and a model of PBC has been described in which polyinosinic-polycytidylic acid (poly I:C), a viral RNA mimetic and Toll-like receptor 3 (TLR-3) agonist induces low-titre AMAs and in mild portal infiltrates.	Poly I-C	181-212	toll-like receptor 3	Mus musculus	271-276
21745520-2	2011	In the present study, we aimed to evaluate the immune responses of peptide-specific CD8(+) T cells induced by HLA-A*0201 restricted severe acute respiratory syndrome-associated coronavirus (SARS-CoV) S epitopes plus CpG oligodeoxynucleotide (CpG ODN), PolyI:C and R848 as adjuvants.	Poly I-C	252-259	major histocompatibility complex, class I, A	Homo sapiens	110-115
21653747-4	2011	As a model system for particle release, RAW 264.7 cells were stimulated in vitro with poly(I:C), a ligand of TLR3.	Poly I-C	86-95	toll-like receptor 3	Mus musculus	109-113
22977599-3	2011	Polyinosinic-polycytidylic acid, referred to as poly(I:C), an analog of viral dsRNA, interacts with TLR3 thereby eliciting immunoinflammatory responses characteristic of viral infection or down-regulating the expression of chemokine receptor CXCR4.	Poly I-C	0-31	toll like receptor 3	Homo sapiens	100-104
22977599-3	2011	Polyinosinic-polycytidylic acid, referred to as poly(I:C), an analog of viral dsRNA, interacts with TLR3 thereby eliciting immunoinflammatory responses characteristic of viral infection or down-regulating the expression of chemokine receptor CXCR4.	Poly I-C	0-31	C-X-C motif chemokine receptor 4	Homo sapiens	242-247
22977599-8	2011	The same trend was observed for IFNgamma where in the presence of poly(I:C) an 8.7-fold increase was noted and in the presence of endogenous RNA a 3.1-fold decrease was observed.	Poly I-C	66-75	interferon gamma	Homo sapiens	32-40
21674566-5	2011	Moreover, the prenatal Poly I:C injection impaired synaptic development of the upper-layer neurons at a later stage, and there was a decrease in the synaptophysin- and glutamic acid decarboxylase-67-positive puncta surrounding the neuronal cell bodies and an increase in the dendritic spine density in postnatal 8-week-old offspring.	Poly I-C	23-31	synaptophysin	Mus musculus	149-162
21684348-5	2011	IL-33 mRNA and protein were largely induced by various microbial components, mainly by polyI:C and flagellin, the ligands to TLR3 and TLR5, respectively in human corneal epithelium ex vivo and in vitro cultures.	Poly I-C	87-94	interleukin 33	Homo sapiens	0-5
21684348-5	2011	IL-33 mRNA and protein were largely induced by various microbial components, mainly by polyI:C and flagellin, the ligands to TLR3 and TLR5, respectively in human corneal epithelium ex vivo and in vitro cultures.	Poly I-C	87-94	toll like receptor 3	Homo sapiens	125-129
21684348-5	2011	IL-33 mRNA and protein were largely induced by various microbial components, mainly by polyI:C and flagellin, the ligands to TLR3 and TLR5, respectively in human corneal epithelium ex vivo and in vitro cultures.	Poly I-C	87-94	toll like receptor 5	Homo sapiens	134-138
21684348-7	2011	The PolyI:C induced IL-33 production was blocked by TLR3 antibody or TRIF Inhibitory peptide, while flagellin stimulated IL-33 was blocked by TLR5 antibody or MyD88 Inhibitory peptide.	Poly I-C	4-11	interleukin 33	Homo sapiens	20-25
21684348-7	2011	The PolyI:C induced IL-33 production was blocked by TLR3 antibody or TRIF Inhibitory peptide, while flagellin stimulated IL-33 was blocked by TLR5 antibody or MyD88 Inhibitory peptide.	Poly I-C	4-11	toll like receptor 3	Homo sapiens	52-56
21684348-7	2011	The PolyI:C induced IL-33 production was blocked by TLR3 antibody or TRIF Inhibitory peptide, while flagellin stimulated IL-33 was blocked by TLR5 antibody or MyD88 Inhibitory peptide.	Poly I-C	4-11	TIR domain containing adaptor molecule 1	Homo sapiens	69-73
21684348-8	2011	Interestingly, IkappaB-alpha inhibitor (BAY11-7082) or NF-kappaB inhibitor (quinazoline) blocked NF-kappaB p65 protein nuclear translocation, and suppressed IL-33 production induced by PolyI:C and flagellin.	Poly I-C	185-192	NFKB inhibitor alpha	Homo sapiens	15-28
21684348-8	2011	Interestingly, IkappaB-alpha inhibitor (BAY11-7082) or NF-kappaB inhibitor (quinazoline) blocked NF-kappaB p65 protein nuclear translocation, and suppressed IL-33 production induced by PolyI:C and flagellin.	Poly I-C	185-192	RELA proto-oncogene, NF-kB subunit	Homo sapiens	97-110
21684348-8	2011	Interestingly, IkappaB-alpha inhibitor (BAY11-7082) or NF-kappaB inhibitor (quinazoline) blocked NF-kappaB p65 protein nuclear translocation, and suppressed IL-33 production induced by PolyI:C and flagellin.	Poly I-C	185-192	interleukin 33	Homo sapiens	157-162
21704380-4	2011	Trout IL-6 (tIL-6) expression in macrophages could be induced by proinflammatory agents (LPS, polyI:C, and IL-1beta) and recombinant tIL-6 (rtIL-6) rapidly induced STAT3 phosphorylation and expression of SOCS-1 to -3, CISH and IRF-1, as seen in mammals.	Poly I-C	94-101	interleukin-6	Oncorhynchus mykiss	6-10
21697465-3	2011	Poly(I   C), a synthetic analogue of viral dsRNA, rapidly triggers caspase 8 activation and apoptosis in HeLa cells.	Poly I-C	0-10	caspase 8	Homo sapiens	67-76
21697465-6	2011	Individually expressed HSV R1s counteracted caspase 8 activation by poly(I   C).	Poly I-C	68-78	caspase 8	Homo sapiens	44-53
21697465-10	2011	TRIF silencing reduced poly(I   C)-triggered caspase 8 activation in mock- and ICP6Delta-infected cells, confirming that TRIF is involved in poly(I   C)-induced apoptosis.	Poly I-C	23-34	TIR domain containing adaptor molecule 1	Homo sapiens	0-4
21697465-10	2011	TRIF silencing reduced poly(I   C)-triggered caspase 8 activation in mock- and ICP6Delta-infected cells, confirming that TRIF is involved in poly(I   C)-induced apoptosis.	Poly I-C	23-34	caspase 8	Homo sapiens	45-54
21697465-10	2011	TRIF silencing reduced poly(I   C)-triggered caspase 8 activation in mock- and ICP6Delta-infected cells, confirming that TRIF is involved in poly(I   C)-induced apoptosis.	Poly I-C	23-34	TIR domain containing adaptor molecule 1	Homo sapiens	121-125
21697465-10	2011	TRIF silencing reduced poly(I   C)-triggered caspase 8 activation in mock- and ICP6Delta-infected cells, confirming that TRIF is involved in poly(I   C)-induced apoptosis.	Poly I-C	141-152	TIR domain containing adaptor molecule 1	Homo sapiens	0-4
21697465-10	2011	TRIF silencing reduced poly(I   C)-triggered caspase 8 activation in mock- and ICP6Delta-infected cells, confirming that TRIF is involved in poly(I   C)-induced apoptosis.	Poly I-C	141-152	caspase 8	Homo sapiens	45-54
21697465-10	2011	TRIF silencing reduced poly(I   C)-triggered caspase 8 activation in mock- and ICP6Delta-infected cells, confirming that TRIF is involved in poly(I   C)-induced apoptosis.	Poly I-C	141-152	TIR domain containing adaptor molecule 1	Homo sapiens	121-125
21931545-3	2011	Here, we show that HAV also disrupts TLR3 signaling, inhibiting poly(I:C)-stimulated dimerization of IFN regulatory factor 3 (IRF-3), IRF-3 translocation to the nucleus, and IFN-beta promoter activation, by targeting TRIF for degradation by a distinct 3ABCD processing intermediate, the 3CD protease-polymerase precursor.	Poly I-C	64-73	toll like receptor 3	Homo sapiens	37-41
21931545-3	2011	Here, we show that HAV also disrupts TLR3 signaling, inhibiting poly(I:C)-stimulated dimerization of IFN regulatory factor 3 (IRF-3), IRF-3 translocation to the nucleus, and IFN-beta promoter activation, by targeting TRIF for degradation by a distinct 3ABCD processing intermediate, the 3CD protease-polymerase precursor.	Poly I-C	64-73	TIR domain containing adaptor molecule 1	Homo sapiens	217-221
21715345-10	2011	A significant increase in expression levels of IL-6, TNF-alpha, IL-8, MCP-1, ICAM-1, and BFGF was observed after poly (I:C) RNA stimulation (P < 0.05).	Poly I-C	113-123	interleukin 6	Homo sapiens	47-51
21654189-4	2011	We demonstrate that both poly (I:C) and lipopolysaccharide (LPS) induce expression of IDO in synovial fibroblasts.	Poly I-C	25-34	indoleamine 2,3-dioxygenase 1	Homo sapiens	86-89
21654189-6	2011	Poly (I:C) appeared to induce higher IDO expression than did LPS.	Poly I-C	0-9	indoleamine 2,3-dioxygenase 1	Homo sapiens	37-40
21715345-10	2011	A significant increase in expression levels of IL-6, TNF-alpha, IL-8, MCP-1, ICAM-1, and BFGF was observed after poly (I:C) RNA stimulation (P < 0.05).	Poly I-C	113-123	tumor necrosis factor	Homo sapiens	53-62
21715345-9	2011	Poly (I:C) RNA stimulation led to a dose-dependent increase in the expression of TLR3 and RIG-I.	Poly I-C	0-9	toll like receptor 3	Homo sapiens	81-85
21715345-10	2011	A significant increase in expression levels of IL-6, TNF-alpha, IL-8, MCP-1, ICAM-1, and BFGF was observed after poly (I:C) RNA stimulation (P < 0.05).	Poly I-C	113-123	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
21715345-9	2011	Poly (I:C) RNA stimulation led to a dose-dependent increase in the expression of TLR3 and RIG-I.	Poly I-C	0-9	DExD/H-box helicase 58	Homo sapiens	90-95
21715345-10	2011	A significant increase in expression levels of IL-6, TNF-alpha, IL-8, MCP-1, ICAM-1, and BFGF was observed after poly (I:C) RNA stimulation (P < 0.05).	Poly I-C	113-123	C-C motif chemokine ligand 2	Homo sapiens	70-75
21715345-10	2011	A significant increase in expression levels of IL-6, TNF-alpha, IL-8, MCP-1, ICAM-1, and BFGF was observed after poly (I:C) RNA stimulation (P < 0.05).	Poly I-C	113-123	intercellular adhesion molecule 1	Homo sapiens	77-83
21715345-10	2011	A significant increase in expression levels of IL-6, TNF-alpha, IL-8, MCP-1, ICAM-1, and BFGF was observed after poly (I:C) RNA stimulation (P < 0.05).	Poly I-C	113-123	fibroblast growth factor 2	Homo sapiens	89-93
21730023-2	2011	Here, we report that among all TLR agonists tested, dendritic cells (DC) stimulated with the TLR3 agonist polyI:C displayed the strongest activity in stimulating proinflammatory responses and the production of melanoma antigen-specific CD8(+) T cells.	Poly I-C	106-113	toll like receptor 3	Homo sapiens	93-97
21709606-8	2011	Remarkably, this clone also recognized the DBX homologue peptide and responded to female donor dendritic cells stimulated with poly I/C or lipopolysaccharide, indicating that the peptide was endogenously processed in these cells.	Poly I-C	127-135	DEAD-box helicase 3 X-linked	Homo sapiens	43-46
21861882-5	2011	The effect of TLR3 agonist, polyinosinic-polycytidylic acid (poly(I:C)), on the growth of human NB cells was evaluated by WST-1 cell proliferation assay, flow cytometry analysis, and immunoblot analysis.	Poly I-C	28-59	toll like receptor 3	Homo sapiens	14-18
21861882-5	2011	The effect of TLR3 agonist, polyinosinic-polycytidylic acid (poly(I:C)), on the growth of human NB cells was evaluated by WST-1 cell proliferation assay, flow cytometry analysis, and immunoblot analysis.	Poly I-C	61-70	toll like receptor 3	Homo sapiens	14-18
21861882-9	2011	Treatment with poly(I:C) elicited significant growth inhibition and apoptosis only in high TLR3-expressing SK-N-AS cells, but not in low TLR3-expressing SK-N-FI and SK-N-DZ cells.	Poly I-C	15-23	toll like receptor 3	Homo sapiens	91-95
21861882-10	2011	Moreover, poly(I:C) treatment significantly stimulated the activities of PKR, interferon regulatory factor 3 (IRF-3) and caspase-3 in SK-N-AS cells.	Poly I-C	10-19	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	73-76
21861882-10	2011	Moreover, poly(I:C) treatment significantly stimulated the activities of PKR, interferon regulatory factor 3 (IRF-3) and caspase-3 in SK-N-AS cells.	Poly I-C	10-19	interferon regulatory factor 3	Homo sapiens	78-108
21861882-10	2011	Moreover, poly(I:C) treatment significantly stimulated the activities of PKR, interferon regulatory factor 3 (IRF-3) and caspase-3 in SK-N-AS cells.	Poly I-C	10-19	interferon regulatory factor 3	Homo sapiens	110-115
21861882-10	2011	Moreover, poly(I:C) treatment significantly stimulated the activities of PKR, interferon regulatory factor 3 (IRF-3) and caspase-3 in SK-N-AS cells.	Poly I-C	10-19	caspase 3	Homo sapiens	121-130
21861882-11	2011	Application of TLR3 neutralizing antibody or small interference RNA (siRNA) reduced the poly(I:C)-induced inhibition of cell proliferation and apoptosis in SK-N-AS cells.	Poly I-C	88-97	toll like receptor 3	Homo sapiens	15-19
21861882-13	2011	Finally, application of 2-AP attenuated the poly(I:C)-induced IRF-3 and caspase-3 activation in SK-N-AS cells.	Poly I-C	44-53	interferon regulatory factor 3	Homo sapiens	62-67
21861882-13	2011	Finally, application of 2-AP attenuated the poly(I:C)-induced IRF-3 and caspase-3 activation in SK-N-AS cells.	Poly I-C	44-53	caspase 3	Homo sapiens	72-81
21526359-8	2011	Intraperitoneal administration of poly(I:C) with PEI led to the uptake of poly(I:C) mainly by CD11b+ macrophages, resulting in the high expression of MHC class II and IL-12 (M1 phenotype).	Poly I-C	34-42	integrin alpha M	Mus musculus	94-99
21812954-10	2011	Poly(I:C)-induced loss of preOLs was abolished in TNFalpha or TNFR1 deficient mixed glial cultures, suggesting that TNFalpha/TNFR1 signaling is required for poly(I:C) toxicity.	Poly I-C	157-165	TNF receptor superfamily member 1A	Rattus norvegicus	62-67
21812954-10	2011	Poly(I:C)-induced loss of preOLs was abolished in TNFalpha or TNFR1 deficient mixed glial cultures, suggesting that TNFalpha/TNFR1 signaling is required for poly(I:C) toxicity.	Poly I-C	157-165	tumor necrosis factor	Rattus norvegicus	116-124
21812954-10	2011	Poly(I:C)-induced loss of preOLs was abolished in TNFalpha or TNFR1 deficient mixed glial cultures, suggesting that TNFalpha/TNFR1 signaling is required for poly(I:C) toxicity.	Poly I-C	157-165	TNF receptor superfamily member 1A	Rattus norvegicus	125-130
21526359-8	2011	Intraperitoneal administration of poly(I:C) with PEI led to the uptake of poly(I:C) mainly by CD11b+ macrophages, resulting in the high expression of MHC class II and IL-12 (M1 phenotype).	Poly I-C	74-82	integrin alpha M	Mus musculus	94-99
20652827-14	2011	Data of Western blot revealed that poly I:C-induced p-ERK, p-JNK, and pp38 expression, but not pp65, were suppressed by procaterol.	Poly I-C	35-43	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	52-57
21418039-0	2011	Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells.	Poly I-C	15-23	toll like receptor 3	Homo sapiens	98-102
21418039-5	2011	Treatment with Poly I:C alone or combined with ATO-activated TLR3 (Toll-like receptor 3) pathway, increased ROS (reactive oxygen species) generation and mitochondrial dysfunction.	Poly I-C	15-23	toll like receptor 3	Homo sapiens	61-65
21418039-5	2011	Treatment with Poly I:C alone or combined with ATO-activated TLR3 (Toll-like receptor 3) pathway, increased ROS (reactive oxygen species) generation and mitochondrial dysfunction.	Poly I-C	15-23	toll like receptor 3	Homo sapiens	67-87
20652827-14	2011	Data of Western blot revealed that poly I:C-induced p-ERK, p-JNK, and pp38 expression, but not pp65, were suppressed by procaterol.	Poly I-C	35-43	mitogen-activated protein kinase 8	Homo sapiens	61-64
20652827-15	2011	SABAs could suppress poly I:C-induced IP-10 and RANTES expression in bronchial epithelial cells, at least in part, via beta2-adrenoreceptor-cAMP and MAPK-ERK, JNK, and p38 pathways.	Poly I-C	21-29	C-X-C motif chemokine ligand 10	Homo sapiens	38-43
20652827-15	2011	SABAs could suppress poly I:C-induced IP-10 and RANTES expression in bronchial epithelial cells, at least in part, via beta2-adrenoreceptor-cAMP and MAPK-ERK, JNK, and p38 pathways.	Poly I-C	21-29	C-C motif chemokine ligand 5	Homo sapiens	48-54
20652827-15	2011	SABAs could suppress poly I:C-induced IP-10 and RANTES expression in bronchial epithelial cells, at least in part, via beta2-adrenoreceptor-cAMP and MAPK-ERK, JNK, and p38 pathways.	Poly I-C	21-29	adrenoceptor beta 2	Homo sapiens	119-139
20652827-15	2011	SABAs could suppress poly I:C-induced IP-10 and RANTES expression in bronchial epithelial cells, at least in part, via beta2-adrenoreceptor-cAMP and MAPK-ERK, JNK, and p38 pathways.	Poly I-C	21-29	mitogen-activated protein kinase 8	Homo sapiens	159-162
20652827-15	2011	SABAs could suppress poly I:C-induced IP-10 and RANTES expression in bronchial epithelial cells, at least in part, via beta2-adrenoreceptor-cAMP and MAPK-ERK, JNK, and p38 pathways.	Poly I-C	21-29	mitogen-activated protein kinase 14	Homo sapiens	168-171
21501152-0	2011	Nuclear factor kappa B plays a pivotal role in polyinosinic-polycytidylic acid-induced expression of human beta-defensin 2 in intestinal epithelial cells.	Poly I-C	47-78	nuclear factor kappa B subunit 1	Homo sapiens	0-22
21478252-6	2011	Inhibitory effects of poly(I:C) on AFC were absent in TLR-3(-/-) mice and were not replicated by addition to the AFC instillate of ligands for other TLRs except TLR-2.	Poly I-C	22-31	toll-like receptor 3	Mus musculus	54-59
21777518-7	2011	IPOP inhibited lipopolysaccharide- or polyinosinic-polycytidylic acid-induced interferon regulatory factor 3 activation, as well as interferon- inducible genes such as interferon inducible protein-10.	Poly I-C	38-69	interferon regulatory factor 3	Homo sapiens	78-108
21501152-0	2011	Nuclear factor kappa B plays a pivotal role in polyinosinic-polycytidylic acid-induced expression of human beta-defensin 2 in intestinal epithelial cells.	Poly I-C	47-78	defensin beta 4A	Homo sapiens	107-122
21501152-4	2011	In the present study, using an artificial analogue of dsRNA, polyinosinic-polycytidylic acid (poly I:C), we investigated whether the human IEC line, HT-29, can produce hBD-2 in response to poly I:C.	Poly I-C	61-92	defensin beta 4A	Homo sapiens	168-173
21501152-7	2011	Detection of the poly I:C signal by TLR-3 on the surface of HT-29 cells was revealed by pre-incubating the cells with anti-TLR-3 antibody.	Poly I-C	17-25	toll like receptor 3	Homo sapiens	36-41
21501152-7	2011	Detection of the poly I:C signal by TLR-3 on the surface of HT-29 cells was revealed by pre-incubating the cells with anti-TLR-3 antibody.	Poly I-C	17-25	toll like receptor 3	Homo sapiens	123-128
21501152-9	2011	A luciferase assay revealed the importance of the proximal NF-kappaB binding site for poly I:C-induced expression of hBD-2.	Poly I-C	86-94	nuclear factor kappa B subunit 1	Homo sapiens	59-68
21501152-9	2011	A luciferase assay revealed the importance of the proximal NF-kappaB binding site for poly I:C-induced expression of hBD-2.	Poly I-C	86-94	defensin beta 4A	Homo sapiens	117-122
21501152-10	2011	Among NF-kappaB subunits, p65 and p50 were activated by poly I:C stimulation and accumulated in the nucleus.	Poly I-C	56-64	nuclear factor kappa B subunit 1	Homo sapiens	6-15
21501152-10	2011	Among NF-kappaB subunits, p65 and p50 were activated by poly I:C stimulation and accumulated in the nucleus.	Poly I-C	56-64	RELA proto-oncogene, NF-kB subunit	Homo sapiens	26-29
21501152-10	2011	Among NF-kappaB subunits, p65 and p50 were activated by poly I:C stimulation and accumulated in the nucleus.	Poly I-C	56-64	nuclear factor kappa B subunit 1	Homo sapiens	34-37
21501152-11	2011	Activation of the p65 subunit was investigated further by determining its phosphorylation status, which revealed that poly I:C stimulation resulted in prolonged phosphorylation of p65.	Poly I-C	118-126	RELA proto-oncogene, NF-kB subunit	Homo sapiens	18-21
21501152-11	2011	Activation of the p65 subunit was investigated further by determining its phosphorylation status, which revealed that poly I:C stimulation resulted in prolonged phosphorylation of p65.	Poly I-C	118-126	RELA proto-oncogene, NF-kB subunit	Homo sapiens	180-183
21501152-12	2011	These results indicate clearly that NF-kappaB plays an indispensable role in poly I:C induced hBD-2 expression in HT-29 cells.	Poly I-C	77-85	nuclear factor kappa B subunit 1	Homo sapiens	36-45
21501152-12	2011	These results indicate clearly that NF-kappaB plays an indispensable role in poly I:C induced hBD-2 expression in HT-29 cells.	Poly I-C	77-85	defensin beta 4A	Homo sapiens	94-99
21337319-8	2011	Stimulation with poly(I-C) induced the activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and activator protein 1 (AP-1) c-Jun as well as the subsequent production of IFNbeta, CXCL8, and MMP-3.	Poly I-C	17-25	interferon regulatory factor 3	Homo sapiens	53-76
21646299-5	2011	Significant TLR3-mediated apoptosis was induced by polyinosinic-polycytidylic acid, a dsRNA analog, via caspase-8-dependent mechanisms.	Poly I-C	51-82	toll like receptor 3	Homo sapiens	12-16
21646299-5	2011	Significant TLR3-mediated apoptosis was induced by polyinosinic-polycytidylic acid, a dsRNA analog, via caspase-8-dependent mechanisms.	Poly I-C	51-82	caspase 8	Homo sapiens	104-113
21646299-6	2011	However, insulin efficiently inhibited TLR3/polyinosinic-polycytidylic acid-induced human bronchial epithelial cell apoptosis via PI3K/Akt and ERK pathways, at least in part, via upregulation of cellular FLIPs and through protein synthesis-independent mechanisms.	Poly I-C	44-75	insulin	Homo sapiens	9-16
21646299-6	2011	However, insulin efficiently inhibited TLR3/polyinosinic-polycytidylic acid-induced human bronchial epithelial cell apoptosis via PI3K/Akt and ERK pathways, at least in part, via upregulation of cellular FLIPs and through protein synthesis-independent mechanisms.	Poly I-C	44-75	toll like receptor 3	Homo sapiens	39-43
21646299-6	2011	However, insulin efficiently inhibited TLR3/polyinosinic-polycytidylic acid-induced human bronchial epithelial cell apoptosis via PI3K/Akt and ERK pathways, at least in part, via upregulation of cellular FLIPs and through protein synthesis-independent mechanisms.	Poly I-C	44-75	AKT serine/threonine kinase 1	Homo sapiens	135-138
21646299-6	2011	However, insulin efficiently inhibited TLR3/polyinosinic-polycytidylic acid-induced human bronchial epithelial cell apoptosis via PI3K/Akt and ERK pathways, at least in part, via upregulation of cellular FLIPs and through protein synthesis-independent mechanisms.	Poly I-C	44-75	mitogen-activated protein kinase 1	Homo sapiens	143-146
21546084-2	2011	The artificial TLR3 ligand, PolyI:C, induces an inflammatory response in trophoblasts but an endogenous ligand has not been identified.	Poly I-C	28-35	toll like receptor 3	Homo sapiens	15-19
21669398-6	2011	Systemic administration of poly I:C or IFN-beta or infection with murine norovirus-1 promoted inflammation and lethality in mice superinfected with E. coli, which was independent of bacterial burden but attenuated in the absence of Nod1/Nod2 or Rip2.	Poly I-C	27-35	nucleotide binding oligomerization domain containing 2	Homo sapiens	237-241
21669398-6	2011	Systemic administration of poly I:C or IFN-beta or infection with murine norovirus-1 promoted inflammation and lethality in mice superinfected with E. coli, which was independent of bacterial burden but attenuated in the absence of Nod1/Nod2 or Rip2.	Poly I-C	27-35	receptor interacting serine/threonine kinase 2	Homo sapiens	245-249
21555533-5	2011	In addition, BST2-mediated Ag delivery in the presence of polyinosinic-polycytidylic acid as adjuvant induces cytotoxic T lymphocytes that are functional in vivo.	Poly I-C	58-89	bone marrow stromal cell antigen 2	Mus musculus	13-17
20656951-3	2011	The variant enhances AP-1 binding to the regulatory element, and increases the promoter--reporter activity of TSLP in response to polyinosinic-polycytidylic acid (poly[I:C]) stimulation in normal human bronchial epithelium (NHBE).	Poly I-C	130-161	thymic stromal lymphopoietin	Homo sapiens	110-114
21337319-8	2011	Stimulation with poly(I-C) induced the activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and activator protein 1 (AP-1) c-Jun as well as the subsequent production of IFNbeta, CXCL8, and MMP-3.	Poly I-C	17-25	interferon regulatory factor 3	Homo sapiens	78-83
21337319-8	2011	Stimulation with poly(I-C) induced the activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and activator protein 1 (AP-1) c-Jun as well as the subsequent production of IFNbeta, CXCL8, and MMP-3.	Poly I-C	17-25	nuclear factor kappa B subunit 1	Homo sapiens	86-95
21337319-8	2011	Stimulation with poly(I-C) induced the activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and activator protein 1 (AP-1) c-Jun as well as the subsequent production of IFNbeta, CXCL8, and MMP-3.	Poly I-C	17-25	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	101-120
21337319-8	2011	Stimulation with poly(I-C) induced the activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and activator protein 1 (AP-1) c-Jun as well as the subsequent production of IFNbeta, CXCL8, and MMP-3.	Poly I-C	17-25	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	122-126
21337319-8	2011	Stimulation with poly(I-C) induced the activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and activator protein 1 (AP-1) c-Jun as well as the subsequent production of IFNbeta, CXCL8, and MMP-3.	Poly I-C	17-25	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	128-133
21337319-8	2011	Stimulation with poly(I-C) induced the activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and activator protein 1 (AP-1) c-Jun as well as the subsequent production of IFNbeta, CXCL8, and MMP-3.	Poly I-C	17-25	interferon beta 1	Homo sapiens	174-181
21337319-8	2011	Stimulation with poly(I-C) induced the activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and activator protein 1 (AP-1) c-Jun as well as the subsequent production of IFNbeta, CXCL8, and MMP-3.	Poly I-C	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	183-188
21337319-8	2011	Stimulation with poly(I-C) induced the activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and activator protein 1 (AP-1) c-Jun as well as the subsequent production of IFNbeta, CXCL8, and MMP-3.	Poly I-C	17-25	matrix metallopeptidase 3	Homo sapiens	194-199
21428909-3	2011	Studies using specific pharmacological inhibitors revealed the involvement of NF-kappaB, p38 MAPK, and PI-3K signal transduction pathways in poly (I:C)-induced MMP-9 gene expression.	Poly I-C	141-151	nuclear factor kappa B subunit 1	Homo sapiens	78-87
21433044-3	2011	PolyI:C administration down-regulates expression of retinoic X receptor-alpha (RXRalpha) as well as its heterodimeric partner pregnane X receptor (PXR) in mice.	Poly I-C	0-7	retinoid X receptor alpha	Mus musculus	79-87
21433044-3	2011	PolyI:C administration down-regulates expression of retinoic X receptor-alpha (RXRalpha) as well as its heterodimeric partner pregnane X receptor (PXR) in mice.	Poly I-C	0-7	nuclear receptor subfamily 1, group I, member 2	Mus musculus	126-145
21433044-3	2011	PolyI:C administration down-regulates expression of retinoic X receptor-alpha (RXRalpha) as well as its heterodimeric partner pregnane X receptor (PXR) in mice.	Poly I-C	0-7	nuclear receptor subfamily 1, group I, member 2	Mus musculus	147-150
21433044-6	2011	Furthermore, we demonstrate that polyI:C can attenuate APAP metabolism through both its membrane-bound receptor, Toll-like receptor 3 (TLR3), as well as cytoplasmic receptors.	Poly I-C	33-40	toll like receptor 3	Homo sapiens	113-133
21433044-6	2011	Furthermore, we demonstrate that polyI:C can attenuate APAP metabolism through both its membrane-bound receptor, Toll-like receptor 3 (TLR3), as well as cytoplasmic receptors.	Poly I-C	33-40	toll like receptor 3	Homo sapiens	135-139
21428909-3	2011	Studies using specific pharmacological inhibitors revealed the involvement of NF-kappaB, p38 MAPK, and PI-3K signal transduction pathways in poly (I:C)-induced MMP-9 gene expression.	Poly I-C	141-151	mitogen-activated protein kinase 14	Homo sapiens	89-92
21428909-3	2011	Studies using specific pharmacological inhibitors revealed the involvement of NF-kappaB, p38 MAPK, and PI-3K signal transduction pathways in poly (I:C)-induced MMP-9 gene expression.	Poly I-C	141-151	matrix metallopeptidase 9	Homo sapiens	160-165
21428909-5	2011	However, cycloheximide treatment only partially blocked poly (I:C)-induced MMP-9 gene expression.	Poly I-C	56-66	matrix metallopeptidase 9	Homo sapiens	75-80
21342182-8	2011	Nonetheless, in tonsillar mononuclear cells iE-DAP, MDP and Poly(I:C)/LyoVec were found to augment the CD3/CD28-induced proliferation of tonsillar mononuclear cells.	Poly I-C	60-68	CD28 molecule	Homo sapiens	107-111
21278304-10	2011	Poly(I:C) also inhibited the ability of VEGF to activate extracellular signal-regulated kinase-1, Akt, focal adhesion kinase, and endothelial nitric oxide synthase, and aeroallergen-induced adaptive helper T-cell type 2 inflammation.	Poly I-C	0-8	vascular endothelial growth factor A	Mus musculus	40-44
21278304-10	2011	Poly(I:C) also inhibited the ability of VEGF to activate extracellular signal-regulated kinase-1, Akt, focal adhesion kinase, and endothelial nitric oxide synthase, and aeroallergen-induced adaptive helper T-cell type 2 inflammation.	Poly I-C	0-8	mitogen-activated protein kinase 3	Mus musculus	57-96
21278304-10	2011	Poly(I:C) also inhibited the ability of VEGF to activate extracellular signal-regulated kinase-1, Akt, focal adhesion kinase, and endothelial nitric oxide synthase, and aeroallergen-induced adaptive helper T-cell type 2 inflammation.	Poly I-C	0-8	thymoma viral proto-oncogene 1	Mus musculus	98-101
21278304-10	2011	Poly(I:C) also inhibited the ability of VEGF to activate extracellular signal-regulated kinase-1, Akt, focal adhesion kinase, and endothelial nitric oxide synthase, and aeroallergen-induced adaptive helper T-cell type 2 inflammation.	Poly I-C	0-8	nitric oxide synthase 3, endothelial cell	Mus musculus	130-163
21327636-2	2011	In the present study, we found that Polyinosinic:Polycytidylic Acid [Poly(I:C)] and CpG oligodeoxynucleotide 1826 [CpG], agonists for TLR 3 and 9, respectively, potently activated adoptively transferred T cells against a murine model of established melanoma.	Poly I-C	69-78	toll-like receptor 3	Mus musculus	134-145
21270289-1	2011	Severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro), a deubiquitinating enzyme, reportedly blocks poly I : C-induced activation of interferon regulatory factor 3 and nuclear factor kappa B, reducing interferon (IFN) induction.	Poly I-C	132-142	interferon alpha 1	Homo sapiens	165-175
21270289-1	2011	Severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro), a deubiquitinating enzyme, reportedly blocks poly I : C-induced activation of interferon regulatory factor 3 and nuclear factor kappa B, reducing interferon (IFN) induction.	Poly I-C	132-142	interferon alpha 1	Homo sapiens	233-243
21270289-1	2011	Severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro), a deubiquitinating enzyme, reportedly blocks poly I : C-induced activation of interferon regulatory factor 3 and nuclear factor kappa B, reducing interferon (IFN) induction.	Poly I-C	132-142	interferon alpha 1	Homo sapiens	245-248
21315785-11	2011	In female mice, however, corticosterone does appear to mediate the persistent effects of acute ethanol administration on poly I:C- induced IL-6 levels.	Poly I-C	121-129	interleukin 6	Mus musculus	139-143
21367858-3	2011	In this study, we found that in endothelial cells polyinosinic-polycytidylic acid (poly(I-C)) induced dose- and time-dependent cell apoptosis, which was elicited by TLR3 activation, as TLR3 neutralization and down-regulation repressed the apoptosis.	Poly I-C	50-81	toll like receptor 3	Homo sapiens	165-169
21367858-3	2011	In this study, we found that in endothelial cells polyinosinic-polycytidylic acid (poly(I-C)) induced dose- and time-dependent cell apoptosis, which was elicited by TLR3 activation, as TLR3 neutralization and down-regulation repressed the apoptosis.	Poly I-C	50-81	toll like receptor 3	Homo sapiens	185-189
21367858-3	2011	In this study, we found that in endothelial cells polyinosinic-polycytidylic acid (poly(I-C)) induced dose- and time-dependent cell apoptosis, which was elicited by TLR3 activation, as TLR3 neutralization and down-regulation repressed the apoptosis.	Poly I-C	83-92	toll like receptor 3	Homo sapiens	165-169
21367858-3	2011	In this study, we found that in endothelial cells polyinosinic-polycytidylic acid (poly(I-C)) induced dose- and time-dependent cell apoptosis, which was elicited by TLR3 activation, as TLR3 neutralization and down-regulation repressed the apoptosis.	Poly I-C	83-92	toll like receptor 3	Homo sapiens	185-189
21367858-4	2011	Poly(I-C) induced the activation of both caspases 8 and 9, indicating that TLR3 triggered the signaling of both the extrinsic and intrinsic apoptotic pathways.	Poly I-C	0-8	caspase 8	Homo sapiens	41-57
21367858-4	2011	Poly(I-C) induced the activation of both caspases 8 and 9, indicating that TLR3 triggered the signaling of both the extrinsic and intrinsic apoptotic pathways.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	75-79
21367858-6	2011	Furthermore, poly(I-C) down-regulated anti-apoptotic protein, B cell lymphoma 2 (Bcl-2), and up-regulated Noxa, a key Bcl-2 homology 3-only antagonist of Bcl-2, leading to the priming of the intrinsic pathway.	Poly I-C	13-21	BCL2 apoptosis regulator	Homo sapiens	62-79
21367858-6	2011	Furthermore, poly(I-C) down-regulated anti-apoptotic protein, B cell lymphoma 2 (Bcl-2), and up-regulated Noxa, a key Bcl-2 homology 3-only antagonist of Bcl-2, leading to the priming of the intrinsic pathway.	Poly I-C	13-21	BCL2 apoptosis regulator	Homo sapiens	81-86
21367858-6	2011	Furthermore, poly(I-C) down-regulated anti-apoptotic protein, B cell lymphoma 2 (Bcl-2), and up-regulated Noxa, a key Bcl-2 homology 3-only antagonist of Bcl-2, leading to the priming of the intrinsic pathway.	Poly I-C	13-21	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	106-110
21367858-6	2011	Furthermore, poly(I-C) down-regulated anti-apoptotic protein, B cell lymphoma 2 (Bcl-2), and up-regulated Noxa, a key Bcl-2 homology 3-only antagonist of Bcl-2, leading to the priming of the intrinsic pathway.	Poly I-C	13-21	BCL2 apoptosis regulator	Homo sapiens	118-123
21367858-6	2011	Furthermore, poly(I-C) down-regulated anti-apoptotic protein, B cell lymphoma 2 (Bcl-2), and up-regulated Noxa, a key Bcl-2 homology 3-only antagonist of Bcl-2, leading to the priming of the intrinsic pathway.	Poly I-C	13-21	BCL2 apoptosis regulator	Homo sapiens	118-123
21145813-9	2011	In vitro HCV proteins NS3 and E2 directly inhibited IL-29 production in poly I:C-stimulated purified DCs.	Poly I-C	72-80	interferon lambda 1	Homo sapiens	52-57
21389871-6	2011	Additional inclusion of polyinosinic: polycytidylic acid during NK-DC cocultures optimized the expression of CD80, CD86, CD40, and HLA-DR on the resulting (NK)DC1, increased their CCR7-mediated migratory responsiveness to the lymph node-associated chemokine CCL21, and further enhanced their IL-12-producing capacity.	Poly I-C	24-56	CD80 molecule	Homo sapiens	109-113
21383019-6	2011	Poly(I-C), a TLR3 ligand, caused caspase-8-independent cellular apoptosis.	Poly I-C	0-8	toll-like receptor 3	Mus musculus	13-17
21383019-6	2011	Poly(I-C), a TLR3 ligand, caused caspase-8-independent cellular apoptosis.	Poly I-C	0-8	caspase 8	Mus musculus	33-42
21383019-7	2011	Whereas poly(I-C) induced retinal cell death in Rdh8(-/-)Abca4(-/-) and WT mice both in vivo and ex vivo, this was not seen in mice lacking Tlr3.	Poly I-C	8-16	retinol dehydrogenase 8	Mus musculus	48-52
21383019-7	2011	Whereas poly(I-C) induced retinal cell death in Rdh8(-/-)Abca4(-/-) and WT mice both in vivo and ex vivo, this was not seen in mice lacking Tlr3.	Poly I-C	8-16	ATP-binding cassette, sub-family A (ABC1), member 4	Mus musculus	57-62
21383019-9	2011	Both poly(I-C) and endogenous products emanating from dying/dead retinal cells induced NF-kappaB and IRF3 activation.	Poly I-C	5-13	interferon regulatory factor 3	Mus musculus	101-105
21400498-3	2011	We show that ER stress greatly potentiates the expression of inflammatory cytokines and IFN-beta in murine DCs stimulated by polyIC, a synthetic mimic of virus dsRNA.	Poly I-C	125-131	interferon beta 1, fibroblast	Mus musculus	88-96
21216459-0	2011	Tuning the immune response of dendritic cells to surface-assembled poly(I:C) on microspheres through synergistic interactions between phagocytic and TLR3 signaling.	Poly I-C	67-75	toll like receptor 3	Homo sapiens	149-153
21346229-6	2011	Specific silencing of IL-32 revealed that the antiviral responses triggered by the synthetic analogs of ssRNA viruses (polyuridine) and dsRNA viruses (polyinosinic-polycytidylic acid) were significantly weaker (2- to 3-fold more virus) in WISH cells in the absence of IL-32.	Poly I-C	151-182	interleukin 32	Homo sapiens	22-27
21389871-6	2011	Additional inclusion of polyinosinic: polycytidylic acid during NK-DC cocultures optimized the expression of CD80, CD86, CD40, and HLA-DR on the resulting (NK)DC1, increased their CCR7-mediated migratory responsiveness to the lymph node-associated chemokine CCL21, and further enhanced their IL-12-producing capacity.	Poly I-C	24-56	CD86 molecule	Homo sapiens	115-119
21346229-7	2011	Importantly, we discovered that the polyinosinic-polycytidylic acid-induced increase in production of IFN-alpha in human PBMC was nearly completely abolished when IL-32 was silenced.	Poly I-C	36-67	interferon alpha 1	Homo sapiens	102-111
21346229-7	2011	Importantly, we discovered that the polyinosinic-polycytidylic acid-induced increase in production of IFN-alpha in human PBMC was nearly completely abolished when IL-32 was silenced.	Poly I-C	36-67	interleukin 32	Homo sapiens	163-168
21389871-6	2011	Additional inclusion of polyinosinic: polycytidylic acid during NK-DC cocultures optimized the expression of CD80, CD86, CD40, and HLA-DR on the resulting (NK)DC1, increased their CCR7-mediated migratory responsiveness to the lymph node-associated chemokine CCL21, and further enhanced their IL-12-producing capacity.	Poly I-C	24-56	CD40 molecule	Homo sapiens	121-125
21389871-6	2011	Additional inclusion of polyinosinic: polycytidylic acid during NK-DC cocultures optimized the expression of CD80, CD86, CD40, and HLA-DR on the resulting (NK)DC1, increased their CCR7-mediated migratory responsiveness to the lymph node-associated chemokine CCL21, and further enhanced their IL-12-producing capacity.	Poly I-C	24-56	C-C motif chemokine receptor 7	Homo sapiens	180-184
21389871-6	2011	Additional inclusion of polyinosinic: polycytidylic acid during NK-DC cocultures optimized the expression of CD80, CD86, CD40, and HLA-DR on the resulting (NK)DC1, increased their CCR7-mediated migratory responsiveness to the lymph node-associated chemokine CCL21, and further enhanced their IL-12-producing capacity.	Poly I-C	24-56	C-C motif chemokine ligand 21	Homo sapiens	258-263
21627015-12	2011	MoDCs matured in the presence of Poly(I:C) up-regulated the production of IL-12 and IL-10, which was followed by increased levels of IFN-gamma and decreased levels of IL-5 in co-cultures with allogeneic CD4+ T cells.	Poly I-C	33-42	interleukin 10	Homo sapiens	84-89
21627015-12	2011	MoDCs matured in the presence of Poly(I:C) up-regulated the production of IL-12 and IL-10, which was followed by increased levels of IFN-gamma and decreased levels of IL-5 in co-cultures with allogeneic CD4+ T cells.	Poly I-C	33-42	interferon gamma	Homo sapiens	133-142
21627015-12	2011	MoDCs matured in the presence of Poly(I:C) up-regulated the production of IL-12 and IL-10, which was followed by increased levels of IFN-gamma and decreased levels of IL-5 in co-cultures with allogeneic CD4+ T cells.	Poly I-C	33-42	interleukin 5	Homo sapiens	167-171
21627015-14	2011	Stimulation of CD40 on Poly(I:C)-treated MoDCs significantly enhanced the production of IL-12, IL-23 and IL-10.	Poly I-C	23-32	CD40 molecule	Homo sapiens	15-19
21627015-14	2011	Stimulation of CD40 on Poly(I:C)-treated MoDCs significantly enhanced the production of IL-12, IL-23 and IL-10.	Poly I-C	23-32	interleukin 23 subunit alpha	Homo sapiens	95-100
21627015-14	2011	Stimulation of CD40 on Poly(I:C)-treated MoDCs significantly enhanced the production of IL-12, IL-23 and IL-10.	Poly I-C	23-32	interleukin 10	Homo sapiens	105-110
21627015-17	2011	Treatment of Poly(I:C)-activated MoDCs with IFN-gamma down-regulated the production of IL-12 and up-regulated IL-10 by these cells and increased/decreased the levels of IL-10/ IFN-gamma, respectively, in co-culture with CD4+ T cells.	Poly I-C	13-22	interferon gamma	Homo sapiens	44-53
21627015-17	2011	Treatment of Poly(I:C)-activated MoDCs with IFN-gamma down-regulated the production of IL-12 and up-regulated IL-10 by these cells and increased/decreased the levels of IL-10/ IFN-gamma, respectively, in co-culture with CD4+ T cells.	Poly I-C	13-22	interleukin 10	Homo sapiens	110-115
21627015-17	2011	Treatment of Poly(I:C)-activated MoDCs with IFN-gamma down-regulated the production of IL-12 and up-regulated IL-10 by these cells and increased/decreased the levels of IL-10/ IFN-gamma, respectively, in co-culture with CD4+ T cells.	Poly I-C	13-22	interleukin 10	Homo sapiens	169-174
21627015-17	2011	Treatment of Poly(I:C)-activated MoDCs with IFN-gamma down-regulated the production of IL-12 and up-regulated IL-10 by these cells and increased/decreased the levels of IL-10/ IFN-gamma, respectively, in co-culture with CD4+ T cells.	Poly I-C	13-22	interferon gamma	Homo sapiens	176-185
21627015-19	2011	Activation of CD40 on Poly(I:C)-treated MoDCs shifts the immune response towards Th17.	Poly I-C	22-31	CD40 molecule	Homo sapiens	14-18
21111765-3	2011	The aim of this study was to design, formulate, and carefully characterize a stable CD8-inducing adjuvant based on the TLR3 ligand polyinosinic-polycytidylic acid [poly(I:C)] incorporated into a cationic adjuvant system (CAF01) composed of dimethyldioctadecylammonium (DDA) and trehalose 6,6"-dibehenate (TDB).	Poly I-C	131-162	toll-like receptor 3	Mus musculus	119-123
21266579-6	2011	Upon poly(I:C) stimulation, Raftlin was translocated from the cytoplasm to the plasma membrane where it colocalized with poly(I:C), and thereafter moved to TLR3-positive endosomes.	Poly I-C	5-14	raftlin, lipid raft linker 1	Homo sapiens	28-35
21111765-3	2011	The aim of this study was to design, formulate, and carefully characterize a stable CD8-inducing adjuvant based on the TLR3 ligand polyinosinic-polycytidylic acid [poly(I:C)] incorporated into a cationic adjuvant system (CAF01) composed of dimethyldioctadecylammonium (DDA) and trehalose 6,6"-dibehenate (TDB).	Poly I-C	164-173	toll-like receptor 3	Mus musculus	119-123
21111765-8	2011	Importantly, whereas injection of soluble poly(I:C) led to rapid production of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in serum, administration of poly(I:C) in complex with the cationic DDA/TDB liposomes prevented this non-specific systemic pro-inflammatory response.	Poly I-C	42-50	tumor necrosis factor	Mus musculus	110-143
21111765-8	2011	Importantly, whereas injection of soluble poly(I:C) led to rapid production of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in serum, administration of poly(I:C) in complex with the cationic DDA/TDB liposomes prevented this non-specific systemic pro-inflammatory response.	Poly I-C	42-50	interleukin 6	Mus musculus	148-166
21111765-8	2011	Importantly, whereas injection of soluble poly(I:C) led to rapid production of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in serum, administration of poly(I:C) in complex with the cationic DDA/TDB liposomes prevented this non-specific systemic pro-inflammatory response.	Poly I-C	195-203	tumor necrosis factor	Mus musculus	110-143
21111765-8	2011	Importantly, whereas injection of soluble poly(I:C) led to rapid production of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in serum, administration of poly(I:C) in complex with the cationic DDA/TDB liposomes prevented this non-specific systemic pro-inflammatory response.	Poly I-C	195-203	interleukin 6	Mus musculus	148-166
21266579-6	2011	Upon poly(I:C) stimulation, Raftlin was translocated from the cytoplasm to the plasma membrane where it colocalized with poly(I:C), and thereafter moved to TLR3-positive endosomes.	Poly I-C	5-14	toll like receptor 3	Homo sapiens	156-160
21266579-6	2011	Upon poly(I:C) stimulation, Raftlin was translocated from the cytoplasm to the plasma membrane where it colocalized with poly(I:C), and thereafter moved to TLR3-positive endosomes.	Poly I-C	5-13	raftlin, lipid raft linker 1	Homo sapiens	28-35
21266579-6	2011	Upon poly(I:C) stimulation, Raftlin was translocated from the cytoplasm to the plasma membrane where it colocalized with poly(I:C), and thereafter moved to TLR3-positive endosomes.	Poly I-C	5-13	toll like receptor 3	Homo sapiens	156-160
21304408-5	2011	Increased IFN-beta expression induced by Poly(I:C) transfection was accompanied by enhanced production of IL-10 and IL-12p70 in the FCs.	Poly I-C	41-50	interferon beta 1	Homo sapiens	10-18
21068089-6	2011	Poly(I:C) induced EDN1, ECE1, and ICAM-1 mRNA expression in poly(I:C) treated skin.	Poly I-C	0-8	endothelin 1	Homo sapiens	18-22
21068089-6	2011	Poly(I:C) induced EDN1, ECE1, and ICAM-1 mRNA expression in poly(I:C) treated skin.	Poly I-C	0-8	endothelin converting enzyme 1	Homo sapiens	24-28
21068089-6	2011	Poly(I:C) induced EDN1, ECE1, and ICAM-1 mRNA expression in poly(I:C) treated skin.	Poly I-C	0-8	intercellular adhesion molecule 1	Homo sapiens	34-40
21068089-6	2011	Poly(I:C) induced EDN1, ECE1, and ICAM-1 mRNA expression in poly(I:C) treated skin.	Poly I-C	60-68	endothelin 1	Homo sapiens	18-22
21068089-6	2011	Poly(I:C) induced EDN1, ECE1, and ICAM-1 mRNA expression in poly(I:C) treated skin.	Poly I-C	60-68	endothelin converting enzyme 1	Homo sapiens	24-28
21068089-6	2011	Poly(I:C) induced EDN1, ECE1, and ICAM-1 mRNA expression in poly(I:C) treated skin.	Poly I-C	60-68	intercellular adhesion molecule 1	Homo sapiens	34-40
21068089-7	2011	Poly(I:C)-induced EDN1, ECE1 and MX2 was not blocked in mice with the type I IFN receptor deleted.	Poly I-C	0-9	endothelin 1	Mus musculus	18-22
21068089-7	2011	Poly(I:C)-induced EDN1, ECE1 and MX2 was not blocked in mice with the type I IFN receptor deleted.	Poly I-C	0-9	endothelin converting enzyme 1	Mus musculus	24-28
21068089-7	2011	Poly(I:C)-induced EDN1, ECE1 and MX2 was not blocked in mice with the type I IFN receptor deleted.	Poly I-C	0-9	MX dynamin-like GTPase 2	Mus musculus	33-36
21068089-8	2011	However, poly(I:C)-induced EDN1 and ECE1, but not poly(I:C)-induced ICAM-1 expression was blocked in mice with the TLR3 signalling protein TRIF/TICAM-1 deleted.	Poly I-C	9-17	endothelin 1	Mus musculus	27-31
21068089-8	2011	However, poly(I:C)-induced EDN1 and ECE1, but not poly(I:C)-induced ICAM-1 expression was blocked in mice with the TLR3 signalling protein TRIF/TICAM-1 deleted.	Poly I-C	9-17	endothelin converting enzyme 1	Mus musculus	36-40
21068089-8	2011	However, poly(I:C)-induced EDN1 and ECE1, but not poly(I:C)-induced ICAM-1 expression was blocked in mice with the TLR3 signalling protein TRIF/TICAM-1 deleted.	Poly I-C	9-17	toll-like receptor 3	Mus musculus	115-119
21068089-8	2011	However, poly(I:C)-induced EDN1 and ECE1, but not poly(I:C)-induced ICAM-1 expression was blocked in mice with the TLR3 signalling protein TRIF/TICAM-1 deleted.	Poly I-C	9-17	toll-like receptor adaptor molecule 1	Mus musculus	139-151
21068089-8	2011	However, poly(I:C)-induced EDN1 and ECE1, but not poly(I:C)-induced ICAM-1 expression was blocked in mice with the TLR3 signalling protein TRIF/TICAM-1 deleted.	Poly I-C	9-18	endothelin 1	Mus musculus	27-31
21068089-8	2011	However, poly(I:C)-induced EDN1 and ECE1, but not poly(I:C)-induced ICAM-1 expression was blocked in mice with the TLR3 signalling protein TRIF/TICAM-1 deleted.	Poly I-C	9-18	endothelin converting enzyme 1	Mus musculus	36-40
21068089-8	2011	However, poly(I:C)-induced EDN1 and ECE1, but not poly(I:C)-induced ICAM-1 expression was blocked in mice with the TLR3 signalling protein TRIF/TICAM-1 deleted.	Poly I-C	9-18	toll-like receptor 3	Mus musculus	115-119
21068089-8	2011	However, poly(I:C)-induced EDN1 and ECE1, but not poly(I:C)-induced ICAM-1 expression was blocked in mice with the TLR3 signalling protein TRIF/TICAM-1 deleted.	Poly I-C	9-18	toll-like receptor adaptor molecule 1	Mus musculus	139-151
21282513-2	2011	In this study, we provide the molecular characterization of Cav1 in pigs following stimulation with LPS/polyinosinic-polycytidylic acid as well as during infection with Haemophilus parasuis.	Poly I-C	104-135	caveolin-1	Sus scrofa	60-64
21282513-8	2011	LPS and polyinosinic-polycytidylic acid markedly induced the expression of Cav1 in porcine kidney-15 cells in vitro, likely through NF-kappaB activation.	Poly I-C	8-39	caveolin-1	Sus scrofa	75-79
21106540-4	2011	Mouse macrophages produce IL-12 and IL-10 in response to TLR ligands such as LPS, CpG, Poly I:C and Malp2.	Poly I-C	87-95	interleukin 10	Mus musculus	36-41
21304408-5	2011	Increased IFN-beta expression induced by Poly(I:C) transfection was accompanied by enhanced production of IL-10 and IL-12p70 in the FCs.	Poly I-C	41-50	interleukin 10	Homo sapiens	106-111
21304408-6	2011	We also found that the ability of Poly(I:C)-transfected FCs to produce IL-12p70, but not IFN-beta, was preserved when endogenous IL-10 was suppressed by IL-10-siRNA.	Poly I-C	34-43	interleukin 10	Homo sapiens	129-134
21304408-6	2011	We also found that the ability of Poly(I:C)-transfected FCs to produce IL-12p70, but not IFN-beta, was preserved when endogenous IL-10 was suppressed by IL-10-siRNA.	Poly I-C	34-43	interleukin 10	Homo sapiens	153-164
21206981-5	2011	When stimulated with poly I:C (and also LPS) JAWSII cells produced large amounts of IL-6, TNF-alpha and MCP-1.	Poly I-C	21-29	interleukin 6	Mus musculus	84-88
21269695-7	2011	Moreover, recipient inflammation with poly (I:C) enhanced RBC alloimmunization to similar degrees in both TRIM21 KO and wild-type control recipients.	Poly I-C	38-48	tripartite motif-containing 21	Mus musculus	106-112
21206981-5	2011	When stimulated with poly I:C (and also LPS) JAWSII cells produced large amounts of IL-6, TNF-alpha and MCP-1.	Poly I-C	21-29	tumor necrosis factor	Mus musculus	90-99
21206981-5	2011	When stimulated with poly I:C (and also LPS) JAWSII cells produced large amounts of IL-6, TNF-alpha and MCP-1.	Poly I-C	21-29	mast cell protease 1	Mus musculus	104-109
21364906-3	2011	We have now examined the effect of triptolide on the expression of matrix metalloproteinases (MMPs) induced by polyinosinic-polycytidylic acid [poly(I:C)], a synthetic analog of viral double-stranded RNA, in cultured human corneal fibroblasts.	Poly I-C	111-142	matrix metallopeptidase 1	Homo sapiens	94-98
21421477-0	2011	[Effect of polyI: C on secretion of thymic stromal lymphopoietin and airway inflammation in mice with respiratory syncytial virus-induced asthma exacerbation].	Poly I-C	11-19	thymic stromal lymphopoietin	Mus musculus	36-64
21421477-1	2011	OBJECTIVE: To investigate the effects of polyinosinic-polycytidylic acid (polyI:C) on the production of thymic stromal lymphopoietin (TSLP) and airway inflammation in mice with exacerbated asthma induced by respiratory syncytial virus (RSV).	Poly I-C	41-72	thymic stromal lymphopoietin	Mus musculus	104-132
21421477-1	2011	OBJECTIVE: To investigate the effects of polyinosinic-polycytidylic acid (polyI:C) on the production of thymic stromal lymphopoietin (TSLP) and airway inflammation in mice with exacerbated asthma induced by respiratory syncytial virus (RSV).	Poly I-C	41-72	thymic stromal lymphopoietin	Mus musculus	134-138
21421477-1	2011	OBJECTIVE: To investigate the effects of polyinosinic-polycytidylic acid (polyI:C) on the production of thymic stromal lymphopoietin (TSLP) and airway inflammation in mice with exacerbated asthma induced by respiratory syncytial virus (RSV).	Poly I-C	74-81	thymic stromal lymphopoietin	Mus musculus	104-132
21421477-1	2011	OBJECTIVE: To investigate the effects of polyinosinic-polycytidylic acid (polyI:C) on the production of thymic stromal lymphopoietin (TSLP) and airway inflammation in mice with exacerbated asthma induced by respiratory syncytial virus (RSV).	Poly I-C	74-81	thymic stromal lymphopoietin	Mus musculus	134-138
21421477-9	2011	Compared with OVA/RSV group, RSV/OVA/polyI:C group showed significantly lower serum levels of IL-4, IL-5, IL-13 and TSLP in BALF (P<0.05), with also lower total BALF cells, eosinophils and lymphocytes (P<0.05) and lessened infiltration of the airway inflammatory cells.	Poly I-C	37-44	interleukin 4	Homo sapiens	94-98
21421477-9	2011	Compared with OVA/RSV group, RSV/OVA/polyI:C group showed significantly lower serum levels of IL-4, IL-5, IL-13 and TSLP in BALF (P<0.05), with also lower total BALF cells, eosinophils and lymphocytes (P<0.05) and lessened infiltration of the airway inflammatory cells.	Poly I-C	37-44	interleukin 5	Homo sapiens	100-104
21421477-9	2011	Compared with OVA/RSV group, RSV/OVA/polyI:C group showed significantly lower serum levels of IL-4, IL-5, IL-13 and TSLP in BALF (P<0.05), with also lower total BALF cells, eosinophils and lymphocytes (P<0.05) and lessened infiltration of the airway inflammatory cells.	Poly I-C	37-44	interleukin 13	Homo sapiens	106-111
21421477-9	2011	Compared with OVA/RSV group, RSV/OVA/polyI:C group showed significantly lower serum levels of IL-4, IL-5, IL-13 and TSLP in BALF (P<0.05), with also lower total BALF cells, eosinophils and lymphocytes (P<0.05) and lessened infiltration of the airway inflammatory cells.	Poly I-C	37-44	thymic stromal lymphopoietin	Homo sapiens	116-120
21421477-10	2011	Immunohistochemistry of TSLP also demonstrated a lower production of TSLP in the airway epithelial cells in RSV/OVA/polyI:C group than in OVA/RSV group.	Poly I-C	116-123	thymic stromal lymphopoietin	Homo sapiens	24-28
21421477-10	2011	Immunohistochemistry of TSLP also demonstrated a lower production of TSLP in the airway epithelial cells in RSV/OVA/polyI:C group than in OVA/RSV group.	Poly I-C	116-123	thymic stromal lymphopoietin	Homo sapiens	69-73
21421477-11	2011	CONCLUSIONS: polyI:C can inhibit the increase in TSLP production in the airway epithelial cells after RSV infection and relieve airway inflammation in mice with RSV-induced asthma exacerbation.	Poly I-C	13-20	thymic stromal lymphopoietin	Homo sapiens	49-53
21364906-7	2011	RESULTS: Poly(I:C) induced the secretion of MMP-1 and MMP-3 from corneal fibroblasts in a concentration-dependent manner as well as increased the intracellular abundance of MMP-1 and MMP-3 mRNAs.	Poly I-C	9-17	matrix metallopeptidase 1	Homo sapiens	44-49
21364906-7	2011	RESULTS: Poly(I:C) induced the secretion of MMP-1 and MMP-3 from corneal fibroblasts in a concentration-dependent manner as well as increased the intracellular abundance of MMP-1 and MMP-3 mRNAs.	Poly I-C	9-17	matrix metallopeptidase 3	Homo sapiens	54-59
21364906-7	2011	RESULTS: Poly(I:C) induced the secretion of MMP-1 and MMP-3 from corneal fibroblasts in a concentration-dependent manner as well as increased the intracellular abundance of MMP-1 and MMP-3 mRNAs.	Poly I-C	9-17	matrix metallopeptidase 1	Homo sapiens	173-178
21364906-7	2011	RESULTS: Poly(I:C) induced the secretion of MMP-1 and MMP-3 from corneal fibroblasts in a concentration-dependent manner as well as increased the intracellular abundance of MMP-1 and MMP-3 mRNAs.	Poly I-C	9-17	matrix metallopeptidase 3	Homo sapiens	183-188
21364906-9	2011	The poly(I:C)-induced secretion of MMP-1 and MMP-3 was also attenuated by synthetic inhibitors of MAPK and NF-kappaB signaling pathways.	Poly I-C	4-12	matrix metallopeptidase 1	Homo sapiens	35-40
21364906-9	2011	The poly(I:C)-induced secretion of MMP-1 and MMP-3 was also attenuated by synthetic inhibitors of MAPK and NF-kappaB signaling pathways.	Poly I-C	4-12	matrix metallopeptidase 3	Homo sapiens	45-50
21364906-9	2011	The poly(I:C)-induced secretion of MMP-1 and MMP-3 was also attenuated by synthetic inhibitors of MAPK and NF-kappaB signaling pathways.	Poly I-C	4-12	mitogen-activated protein kinase 1	Homo sapiens	98-102
21364906-10	2011	Triptolide inhibited the poly(I:C)-induced phosphorylation of IkappaB-alpha but did not affect that of the MAPKs, Extracellular Signal-Regulated Kinase (ERK), p38MAPK, and c-Jun N-Terminal Kinase (JNK).	Poly I-C	25-34	NFKB inhibitor alpha	Homo sapiens	62-75
21364906-11	2011	CONCLUSIONS: Triptolide inhibited the poly(I:C)-induced production of MMP-1 and MMP-3 by human corneal fibroblasts.	Poly I-C	38-47	matrix metallopeptidase 1	Homo sapiens	70-75
21364906-11	2011	CONCLUSIONS: Triptolide inhibited the poly(I:C)-induced production of MMP-1 and MMP-3 by human corneal fibroblasts.	Poly I-C	38-47	matrix metallopeptidase 3	Homo sapiens	80-85
21149657-0	2011	Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in patients with recurrent malignant glioma.	Poly I-C	172-203	CD8a molecule	Homo sapiens	13-16
21349431-5	2011	In vivo, poly(I:C)-induced type I IFN diminished IL-1beta production in response to alum and Candida albicans, thus increasing susceptibility to this fungal pathogen.	Poly I-C	9-18	interferon alpha 1	Homo sapiens	34-37
21349431-5	2011	In vivo, poly(I:C)-induced type I IFN diminished IL-1beta production in response to alum and Candida albicans, thus increasing susceptibility to this fungal pathogen.	Poly I-C	9-18	interleukin 1 beta	Homo sapiens	49-57
21220691-4	2011	In this study, we show that IRF-8 negatively controls TLR3 gene expression by suppressing IRF-1- and/or polyinosinic-polycytidylic acid-stimulated TLR3 expression in primary human monocyte-derived DCs (MDDCs).	Poly I-C	104-135	interferon regulatory factor 8	Homo sapiens	28-33
21220691-4	2011	In this study, we show that IRF-8 negatively controls TLR3 gene expression by suppressing IRF-1- and/or polyinosinic-polycytidylic acid-stimulated TLR3 expression in primary human monocyte-derived DCs (MDDCs).	Poly I-C	104-135	toll like receptor 3	Homo sapiens	54-58
21220691-4	2011	In this study, we show that IRF-8 negatively controls TLR3 gene expression by suppressing IRF-1- and/or polyinosinic-polycytidylic acid-stimulated TLR3 expression in primary human monocyte-derived DCs (MDDCs).	Poly I-C	104-135	toll like receptor 3	Homo sapiens	147-151
21220691-5	2011	MDDCs expressed TLR3 increasingly during their differentiation from monocytes to DCs with a peak at day 5, when TLR3 expression was further enhanced upon stimulation with polyinosinic-polycytidylic acid and then was promptly downregulated.	Poly I-C	171-202	toll like receptor 3	Homo sapiens	16-20
21220691-5	2011	MDDCs expressed TLR3 increasingly during their differentiation from monocytes to DCs with a peak at day 5, when TLR3 expression was further enhanced upon stimulation with polyinosinic-polycytidylic acid and then was promptly downregulated.	Poly I-C	171-202	toll like receptor 3	Homo sapiens	112-116
20981447-4	2011	PBMUCL1 gene expression was remarkably upregulated by polyinosine-polycytidylic acid [poly(I:C)] stimulation in normal human bronchial epithelial cells redifferentiated at the air-liquid interface.	Poly I-C	86-95	mucin 22	Homo sapiens	0-7
21149657-1	2011	PURPOSE: A phase I/II trial was performed to evaluate the safety and immunogenicity of a novel vaccination with alpha-type 1 polarized dendritic cells (alphaDC1) loaded with synthetic peptides for glioma-associated antigen (GAA) epitopes and administration of polyinosinic-polycytidylic acid [poly(I:C)] stabilized by lysine and carboxymethylcellulose (poly-ICLC) in HLA-A2(+) patients with recurrent malignant gliomas.	Poly I-C	260-291	alpha glucosidase	Homo sapiens	197-228
21130742-0	2011	Contribution of IPS-1 to polyI:C-induced cytokine production in conjunctival epithelial cells.	Poly I-C	25-32	mitochondrial antiviral signaling protein	Mus musculus	16-21
21148036-4	2011	To our knowledge, we demonstrate for the first time that polyinosinic-polycytidylic acid [poly (I:C)], a synthetic dsRNA analogue that signals via TLR3, induces sTNFR1 shedding from human airway epithelial (NCI-H292) cells, whereas ligands for other microbial pattern recognition receptors, including TLR4, TLR7, and nucleotide-binding oligomerization domain containing 2, do not.	Poly I-C	57-88	toll like receptor 3	Homo sapiens	147-151
21148036-4	2011	To our knowledge, we demonstrate for the first time that polyinosinic-polycytidylic acid [poly (I:C)], a synthetic dsRNA analogue that signals via TLR3, induces sTNFR1 shedding from human airway epithelial (NCI-H292) cells, whereas ligands for other microbial pattern recognition receptors, including TLR4, TLR7, and nucleotide-binding oligomerization domain containing 2, do not.	Poly I-C	57-88	toll like receptor 4	Homo sapiens	301-305
21148036-4	2011	To our knowledge, we demonstrate for the first time that polyinosinic-polycytidylic acid [poly (I:C)], a synthetic dsRNA analogue that signals via TLR3, induces sTNFR1 shedding from human airway epithelial (NCI-H292) cells, whereas ligands for other microbial pattern recognition receptors, including TLR4, TLR7, and nucleotide-binding oligomerization domain containing 2, do not.	Poly I-C	57-88	toll like receptor 7	Homo sapiens	307-311
21148036-4	2011	To our knowledge, we demonstrate for the first time that polyinosinic-polycytidylic acid [poly (I:C)], a synthetic dsRNA analogue that signals via TLR3, induces sTNFR1 shedding from human airway epithelial (NCI-H292) cells, whereas ligands for other microbial pattern recognition receptors, including TLR4, TLR7, and nucleotide-binding oligomerization domain containing 2, do not.	Poly I-C	90-100	toll like receptor 3	Homo sapiens	147-151
21148036-4	2011	To our knowledge, we demonstrate for the first time that polyinosinic-polycytidylic acid [poly (I:C)], a synthetic dsRNA analogue that signals via TLR3, induces sTNFR1 shedding from human airway epithelial (NCI-H292) cells, whereas ligands for other microbial pattern recognition receptors, including TLR4, TLR7, and nucleotide-binding oligomerization domain containing 2, do not.	Poly I-C	90-100	toll like receptor 4	Homo sapiens	301-305
21148036-4	2011	To our knowledge, we demonstrate for the first time that polyinosinic-polycytidylic acid [poly (I:C)], a synthetic dsRNA analogue that signals via TLR3, induces sTNFR1 shedding from human airway epithelial (NCI-H292) cells, whereas ligands for other microbial pattern recognition receptors, including TLR4, TLR7, and nucleotide-binding oligomerization domain containing 2, do not.	Poly I-C	90-100	toll like receptor 7	Homo sapiens	307-311
21148036-5	2011	Furthermore, poly (I:C) selectively induces the cleavage of 34-kDa sTNFR1 ectodomains but does not enhance the release of full-length 55-kDa TNFR1 within exosome-like vesicles.	Poly I-C	13-22	TNF receptor superfamily member 1A	Homo sapiens	68-73
21148036-6	2011	RNA interference experiments demonstrated that poly (I:C)-induced sTNFR1 shedding is mediated via activation of TLR3-TRIF-RIP1 signaling, with subsequent activation of two downstream pathways.	Poly I-C	47-57	toll like receptor 3	Homo sapiens	112-116
21148036-6	2011	RNA interference experiments demonstrated that poly (I:C)-induced sTNFR1 shedding is mediated via activation of TLR3-TRIF-RIP1 signaling, with subsequent activation of two downstream pathways.	Poly I-C	47-57	TIR domain containing adaptor molecule 1	Homo sapiens	117-121
21148036-6	2011	RNA interference experiments demonstrated that poly (I:C)-induced sTNFR1 shedding is mediated via activation of TLR3-TRIF-RIP1 signaling, with subsequent activation of two downstream pathways.	Poly I-C	47-57	receptor interacting serine/threonine kinase 1	Homo sapiens	122-126
21130742-11	2011	Our results showed that conjunctival epithelial cells express RIG-I and MDA5, and IPS-1, an adaptor molecule common to RIG-I and MDA5, contributes to polyI:C-inducible cytokine production in conjunctival epithelial cells.	Poly I-C	150-157	mitochondrial antiviral signaling protein	Mus musculus	82-87
21130742-11	2011	Our results showed that conjunctival epithelial cells express RIG-I and MDA5, and IPS-1, an adaptor molecule common to RIG-I and MDA5, contributes to polyI:C-inducible cytokine production in conjunctival epithelial cells.	Poly I-C	150-157	DEAD/H box helicase 58	Mus musculus	119-124
21130742-11	2011	Our results showed that conjunctival epithelial cells express RIG-I and MDA5, and IPS-1, an adaptor molecule common to RIG-I and MDA5, contributes to polyI:C-inducible cytokine production in conjunctival epithelial cells.	Poly I-C	150-157	interferon induced with helicase C domain 1	Mus musculus	129-133
21070856-5	2011	Poly I:C-induced a marked pulmonary T cell response in allogeneic HCT mice as compared to syngeneic HCT, with increased CD4+ cells in the lung fluid and tissue.	Poly I-C	0-8	CD4 antigen	Mus musculus	120-123
21070856-6	2011	This lymphocytic inflammation persisted at 2 weeks post poly I:C exposure in allogeneic mice and was associated with CD3+ cell infiltration into the bronchiolar epithelium and features of epithelial injury.	Poly I-C	56-64	CD3 antigen, epsilon polypeptide	Mus musculus	117-120
21070856-8	2011	In vivo, poly I:C exposure was associated with an early increase in pulmonary monocyte recruitment and activation as well as a decrease in CD4+FOXP3+ regulatory T cells in allogeneic mice as compared to syngeneic.	Poly I-C	9-17	CD4 antigen	Mus musculus	139-142
21070856-8	2011	In vivo, poly I:C exposure was associated with an early increase in pulmonary monocyte recruitment and activation as well as a decrease in CD4+FOXP3+ regulatory T cells in allogeneic mice as compared to syngeneic.	Poly I-C	9-17	forkhead box P3	Mus musculus	143-148
21130742-2	2011	It was recently reported that RIG-I and MDA5 also recognize viral dsRNA mimicking polyI:C.	Poly I-C	82-89	DEAD/H box helicase 58	Mus musculus	30-35
21130742-2	2011	It was recently reported that RIG-I and MDA5 also recognize viral dsRNA mimicking polyI:C.	Poly I-C	82-89	interferon induced with helicase C domain 1	Mus musculus	40-44
21130742-3	2011	In this study, we investigated whether RIG-I and/or MDA5 contribute to polyI:C-inducible responses in conjunctival epithelium.	Poly I-C	71-78	DEAD/H box helicase 58	Mus musculus	39-44
21130742-3	2011	In this study, we investigated whether RIG-I and/or MDA5 contribute to polyI:C-inducible responses in conjunctival epithelium.	Poly I-C	71-78	interferon induced with helicase C domain 1	Mus musculus	52-56
21130742-4	2011	The expression of RIG-I, MDA5, and TLR3 in human conjunctival epithelium was examined by RT-PCR and their up-regulation after polyI:C stimulation by quantitative RT-PCR and immunoblot analysis.	Poly I-C	126-133	DExD/H-box helicase 58	Homo sapiens	18-23
21130742-6	2011	The expression of RIG-I and MDA5, but not of TLR3, was markedly up-regulated upon polyI:C stimulation.	Poly I-C	82-89	DEAD/H box helicase 58	Mus musculus	18-23
21130742-6	2011	The expression of RIG-I and MDA5, but not of TLR3, was markedly up-regulated upon polyI:C stimulation.	Poly I-C	82-89	interferon induced with helicase C domain 1	Mus musculus	28-32
21130742-11	2011	Our results showed that conjunctival epithelial cells express RIG-I and MDA5, and IPS-1, an adaptor molecule common to RIG-I and MDA5, contributes to polyI:C-inducible cytokine production in conjunctival epithelial cells.	Poly I-C	150-157	interferon induced with helicase C domain 1	Mus musculus	72-76
21092943-4	2011	These mAbs bind the extracellular domain of mouse TLR3, inhibit poly(I:C)-induced activation of HEK293T cells transfected with mTLR3, and reduce poly(I:C)-induced production of CCL2 and CXCL10 by primary mouse embryonic fibroblasts.	Poly I-C	64-73	toll-like receptor 3	Mus musculus	50-54
20849883-3	2011	To investigate whether this iNOS/Src/FAK pathway is a general mechanism for macrophages to mobilize in response to engagement of TLRs other than TLR4, peptidoglycan (PGN, TLR2 ligand), polyinosinic-polycytidylic acid (polyI:C, TLR3 ligand) and CpG-oligodeoxynucleotides (CpG, TLR9 ligand) were used to treat macrophages in this study.	Poly I-C	185-216	nitric oxide synthase 2	Homo sapiens	28-32
20849883-4	2011	Like LPS stimulation, simultaneous increase of cell motility and Src (but not Fgr, Hck, and Lyn) was detected in RAW264.7, peritoneal macrophages, and bone marrow-derived macrophages exposed to PGN, polyI:C and CpG.	Poly I-C	199-206	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	65-68
21881218-8	2011	In this review, we show how gene-environment interactions during neurodevelopment result in phenotypic changes in adulthood by injecting polyI : C into transgenic mice that express a dominant-negative form of human DISC1 (DN-DISC1).	Poly I-C	137-146	DISC1 scaffold protein	Homo sapiens	215-220
21881218-8	2011	In this review, we show how gene-environment interactions during neurodevelopment result in phenotypic changes in adulthood by injecting polyI : C into transgenic mice that express a dominant-negative form of human DISC1 (DN-DISC1).	Poly I-C	137-146	DISC1 scaffold protein	Homo sapiens	222-230
21881218-9	2011	Our findings suggest that polyI : C-treated DN-DISC1 mice are a well-validated animal model for schizophrenia that reflects gene-environment interactions.	Poly I-C	26-35	disrupted in schizophrenia 1	Mus musculus	44-52
21092943-4	2011	These mAbs bind the extracellular domain of mouse TLR3, inhibit poly(I:C)-induced activation of HEK293T cells transfected with mTLR3, and reduce poly(I:C)-induced production of CCL2 and CXCL10 by primary mouse embryonic fibroblasts.	Poly I-C	64-73	toll-like receptor 3	Mus musculus	127-132
21092943-4	2011	These mAbs bind the extracellular domain of mouse TLR3, inhibit poly(I:C)-induced activation of HEK293T cells transfected with mTLR3, and reduce poly(I:C)-induced production of CCL2 and CXCL10 by primary mouse embryonic fibroblasts.	Poly I-C	64-73	C-X-C motif chemokine ligand 10	Homo sapiens	186-192
21092943-4	2011	These mAbs bind the extracellular domain of mouse TLR3, inhibit poly(I:C)-induced activation of HEK293T cells transfected with mTLR3, and reduce poly(I:C)-induced production of CCL2 and CXCL10 by primary mouse embryonic fibroblasts.	Poly I-C	145-154	toll-like receptor 3	Mus musculus	50-54
21092943-4	2011	These mAbs bind the extracellular domain of mouse TLR3, inhibit poly(I:C)-induced activation of HEK293T cells transfected with mTLR3, and reduce poly(I:C)-induced production of CCL2 and CXCL10 by primary mouse embryonic fibroblasts.	Poly I-C	145-154	C-C motif chemokine ligand 2	Homo sapiens	177-181
21092943-4	2011	These mAbs bind the extracellular domain of mouse TLR3, inhibit poly(I:C)-induced activation of HEK293T cells transfected with mTLR3, and reduce poly(I:C)-induced production of CCL2 and CXCL10 by primary mouse embryonic fibroblasts.	Poly I-C	145-154	C-X-C motif chemokine ligand 10	Homo sapiens	186-192
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	42-73	interleukin 18	Homo sapiens	255-260
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	42-73	interleukin 2	Homo sapiens	273-277
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	42-73	interferon gamma	Homo sapiens	295-304
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	42-73	TNF superfamily member 10	Homo sapiens	320-325
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	42-73	transforming growth factor beta 1	Homo sapiens	371-379
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	42-73	interleukin 10	Homo sapiens	384-389
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	42-73	interferon gamma	Homo sapiens	407-416
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	75-83	interleukin 18	Homo sapiens	255-260
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	75-83	interleukin 2	Homo sapiens	273-277
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	75-83	interferon gamma	Homo sapiens	295-304
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	75-83	TNF superfamily member 10	Homo sapiens	320-325
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	75-83	transforming growth factor beta 1	Homo sapiens	371-379
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	75-83	interleukin 10	Homo sapiens	384-389
21802664-3	2011	Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production.	Poly I-C	75-83	interferon gamma	Homo sapiens	407-416
21106850-4	2011	Association of endogenous TBK1 and Akt was observed in macrophages when stimulated with poly(I:C) and LPS.	Poly I-C	88-97	TANK-binding kinase 1	Mus musculus	26-30
21471724-5	2011	In addition, the suppression of poly(I:C)-induced iNOS expression, and the attenuation of iNOS expression under the IRF-3 gene knock-down condition also confirmed that pinosylvin affects TRIF pathway.	Poly I-C	32-41	nitric oxide synthase 2, inducible	Mus musculus	50-54
20008077-5	2011	In addition, poly I:C led to evident alternations in neuroendocrine and immune systems of mice, such as reduced spontaneous activity and learning ability, declined serum level of corticosterone, increased weight indexes and T lymphocyte numbers in thymuses and spleens, and increased CD4(+)/CD8(+) ratio but decreased proliferation ability of T lymphocytes in spleens.	Poly I-C	13-21	CD4 antigen	Mus musculus	284-287
21106850-4	2011	Association of endogenous TBK1 and Akt was observed in macrophages when stimulated with poly(I:C) and LPS.	Poly I-C	88-97	thymoma viral proto-oncogene 1	Mus musculus	35-38
21106850-6	2011	Embryonic fibroblasts derived from TBK1 knockout mice also showed impaired Akt phosphorylation in response to poly(I:C) and LPS.	Poly I-C	110-118	TANK-binding kinase 1	Mus musculus	35-39
21106850-6	2011	Embryonic fibroblasts derived from TBK1 knockout mice also showed impaired Akt phosphorylation in response to poly(I:C) and LPS.	Poly I-C	110-118	thymoma viral proto-oncogene 1	Mus musculus	75-78
21156324-2	2011	In this study, we found that MDA5 undergoes inducible SUMOylation by small ubiquitin-like modifier-1 (SUMO-1) in response to polyI:C stimulation.	Poly I-C	125-132	interferon induced with helicase C domain 1	Homo sapiens	29-33
20691286-5	2011	HepG2 cells were exposed to TLR-3 ligand (dsRNA--polyinosine-polycytidylic acid; Poly I:C) and mitochondrial respiration was measured.	Poly I-C	81-89	toll like receptor 3	Homo sapiens	28-33
20691286-7	2011	Poly-I:C induced activation of NF-kappaB, and the mitochondrial dysfunction was accompanied by caspase-8 but not caspase-3 activation and by no major alterations in cellular or mitochondrial ultrastructure.	Poly I-C	0-8	nuclear factor kappa B subunit 1	Homo sapiens	31-40
21040977-4	2011	We show that stimulation of moDCs with TLR7/8 ligand R848 together with TLR3 or TLR4 ligands, polyI:C or LPS, respectively, leads to a synergistic expression of IFN-beta and IFN-lambda1 mRNAs.	Poly I-C	94-101	toll like receptor 7	Homo sapiens	39-43
21040977-4	2011	We show that stimulation of moDCs with TLR7/8 ligand R848 together with TLR3 or TLR4 ligands, polyI:C or LPS, respectively, leads to a synergistic expression of IFN-beta and IFN-lambda1 mRNAs.	Poly I-C	94-101	toll like receptor 4	Homo sapiens	80-84
21040977-4	2011	We show that stimulation of moDCs with TLR7/8 ligand R848 together with TLR3 or TLR4 ligands, polyI:C or LPS, respectively, leads to a synergistic expression of IFN-beta and IFN-lambda1 mRNAs.	Poly I-C	94-101	interferon beta 1	Homo sapiens	161-169
21040977-4	2011	We show that stimulation of moDCs with TLR7/8 ligand R848 together with TLR3 or TLR4 ligands, polyI:C or LPS, respectively, leads to a synergistic expression of IFN-beta and IFN-lambda1 mRNAs.	Poly I-C	94-101	interferon lambda 1	Homo sapiens	174-185
21156324-2	2011	In this study, we found that MDA5 undergoes inducible SUMOylation by small ubiquitin-like modifier-1 (SUMO-1) in response to polyI:C stimulation.	Poly I-C	125-132	small ubiquitin like modifier 1	Homo sapiens	69-100
21156324-2	2011	In this study, we found that MDA5 undergoes inducible SUMOylation by small ubiquitin-like modifier-1 (SUMO-1) in response to polyI:C stimulation.	Poly I-C	125-132	small ubiquitin like modifier 1	Homo sapiens	102-108
22206014-3	2011	We set out to delineate the essential signaling pathways by which the RNA-like IRMs, resiquimod (R-848) and polyinosinic:polycytidylic acid (poly I:C), augment CD4+ T-helper 1 (Th1) responses.	Poly I-C	108-139	CD4 antigen	Mus musculus	160-163
21832855-6	2011	RESULTS: Treatment of cells with poly (I:C) induced the expression of ISG20.	Poly I-C	33-42	interferon stimulated exonuclease gene 20	Homo sapiens	70-75
21832855-11	2011	CONCLUSION: Poly (I:C) induces the expression of ISG20 in mesangial cells.	Poly I-C	12-21	interferon stimulated exonuclease gene 20	Homo sapiens	49-54
21832855-13	2011	TLR3, IRF3 and de novo synthesized IFN-beta may mediate the poly (I:C)-induced expression of ISG20, and RIG-I may mediate ISG20 expression induced by poly (I:C)/cationic lipid complex.	Poly I-C	60-70	toll like receptor 3	Homo sapiens	0-4
21832855-13	2011	TLR3, IRF3 and de novo synthesized IFN-beta may mediate the poly (I:C)-induced expression of ISG20, and RIG-I may mediate ISG20 expression induced by poly (I:C)/cationic lipid complex.	Poly I-C	60-70	interferon regulatory factor 3	Homo sapiens	6-10
21832855-13	2011	TLR3, IRF3 and de novo synthesized IFN-beta may mediate the poly (I:C)-induced expression of ISG20, and RIG-I may mediate ISG20 expression induced by poly (I:C)/cationic lipid complex.	Poly I-C	60-70	interferon beta 1	Homo sapiens	35-43
21832855-13	2011	TLR3, IRF3 and de novo synthesized IFN-beta may mediate the poly (I:C)-induced expression of ISG20, and RIG-I may mediate ISG20 expression induced by poly (I:C)/cationic lipid complex.	Poly I-C	60-70	interferon stimulated exonuclease gene 20	Homo sapiens	93-98
21832855-13	2011	TLR3, IRF3 and de novo synthesized IFN-beta may mediate the poly (I:C)-induced expression of ISG20, and RIG-I may mediate ISG20 expression induced by poly (I:C)/cationic lipid complex.	Poly I-C	150-160	interferon stimulated exonuclease gene 20	Homo sapiens	93-98
21832855-13	2011	TLR3, IRF3 and de novo synthesized IFN-beta may mediate the poly (I:C)-induced expression of ISG20, and RIG-I may mediate ISG20 expression induced by poly (I:C)/cationic lipid complex.	Poly I-C	150-160	DExD/H-box helicase 58	Homo sapiens	104-109
21832855-13	2011	TLR3, IRF3 and de novo synthesized IFN-beta may mediate the poly (I:C)-induced expression of ISG20, and RIG-I may mediate ISG20 expression induced by poly (I:C)/cationic lipid complex.	Poly I-C	150-160	interferon stimulated exonuclease gene 20	Homo sapiens	122-127
22046349-4	2011	Our data indicate that the TLR3 ligand polyinosinic-polycytidylic acid (PIC) negatively regulates NPC proliferation by inhibiting Sonic Hedgehog (Shh) signaling, that PIC induces apoptosis in association with inhibition of Ras-ERK signaling and elevated expression of Fas, and that these effects are TLR3-dependent, suggesting convergent signaling between the Shh and TLR3 pathways.	Poly I-C	39-70	toll-like receptor 3	Mus musculus	27-31
22046349-4	2011	Our data indicate that the TLR3 ligand polyinosinic-polycytidylic acid (PIC) negatively regulates NPC proliferation by inhibiting Sonic Hedgehog (Shh) signaling, that PIC induces apoptosis in association with inhibition of Ras-ERK signaling and elevated expression of Fas, and that these effects are TLR3-dependent, suggesting convergent signaling between the Shh and TLR3 pathways.	Poly I-C	39-70	sonic hedgehog	Mus musculus	130-144
22046349-4	2011	Our data indicate that the TLR3 ligand polyinosinic-polycytidylic acid (PIC) negatively regulates NPC proliferation by inhibiting Sonic Hedgehog (Shh) signaling, that PIC induces apoptosis in association with inhibition of Ras-ERK signaling and elevated expression of Fas, and that these effects are TLR3-dependent, suggesting convergent signaling between the Shh and TLR3 pathways.	Poly I-C	39-70	sonic hedgehog	Mus musculus	146-149
22046349-4	2011	Our data indicate that the TLR3 ligand polyinosinic-polycytidylic acid (PIC) negatively regulates NPC proliferation by inhibiting Sonic Hedgehog (Shh) signaling, that PIC induces apoptosis in association with inhibition of Ras-ERK signaling and elevated expression of Fas, and that these effects are TLR3-dependent, suggesting convergent signaling between the Shh and TLR3 pathways.	Poly I-C	39-70	toll-like receptor 3	Mus musculus	300-304
22046349-4	2011	Our data indicate that the TLR3 ligand polyinosinic-polycytidylic acid (PIC) negatively regulates NPC proliferation by inhibiting Sonic Hedgehog (Shh) signaling, that PIC induces apoptosis in association with inhibition of Ras-ERK signaling and elevated expression of Fas, and that these effects are TLR3-dependent, suggesting convergent signaling between the Shh and TLR3 pathways.	Poly I-C	39-70	sonic hedgehog	Mus musculus	360-363
22046349-4	2011	Our data indicate that the TLR3 ligand polyinosinic-polycytidylic acid (PIC) negatively regulates NPC proliferation by inhibiting Sonic Hedgehog (Shh) signaling, that PIC induces apoptosis in association with inhibition of Ras-ERK signaling and elevated expression of Fas, and that these effects are TLR3-dependent, suggesting convergent signaling between the Shh and TLR3 pathways.	Poly I-C	39-70	toll-like receptor 3	Mus musculus	300-304
22046349-4	2011	Our data indicate that the TLR3 ligand polyinosinic-polycytidylic acid (PIC) negatively regulates NPC proliferation by inhibiting Sonic Hedgehog (Shh) signaling, that PIC induces apoptosis in association with inhibition of Ras-ERK signaling and elevated expression of Fas, and that these effects are TLR3-dependent, suggesting convergent signaling between the Shh and TLR3 pathways.	Poly I-C	72-75	toll-like receptor 3	Mus musculus	27-31
22046349-4	2011	Our data indicate that the TLR3 ligand polyinosinic-polycytidylic acid (PIC) negatively regulates NPC proliferation by inhibiting Sonic Hedgehog (Shh) signaling, that PIC induces apoptosis in association with inhibition of Ras-ERK signaling and elevated expression of Fas, and that these effects are TLR3-dependent, suggesting convergent signaling between the Shh and TLR3 pathways.	Poly I-C	72-75	sonic hedgehog	Mus musculus	130-144
22046349-4	2011	Our data indicate that the TLR3 ligand polyinosinic-polycytidylic acid (PIC) negatively regulates NPC proliferation by inhibiting Sonic Hedgehog (Shh) signaling, that PIC induces apoptosis in association with inhibition of Ras-ERK signaling and elevated expression of Fas, and that these effects are TLR3-dependent, suggesting convergent signaling between the Shh and TLR3 pathways.	Poly I-C	72-75	sonic hedgehog	Mus musculus	146-149
22046349-4	2011	Our data indicate that the TLR3 ligand polyinosinic-polycytidylic acid (PIC) negatively regulates NPC proliferation by inhibiting Sonic Hedgehog (Shh) signaling, that PIC induces apoptosis in association with inhibition of Ras-ERK signaling and elevated expression of Fas, and that these effects are TLR3-dependent, suggesting convergent signaling between the Shh and TLR3 pathways.	Poly I-C	72-75	toll-like receptor 3	Mus musculus	300-304
22046349-4	2011	Our data indicate that the TLR3 ligand polyinosinic-polycytidylic acid (PIC) negatively regulates NPC proliferation by inhibiting Sonic Hedgehog (Shh) signaling, that PIC induces apoptosis in association with inhibition of Ras-ERK signaling and elevated expression of Fas, and that these effects are TLR3-dependent, suggesting convergent signaling between the Shh and TLR3 pathways.	Poly I-C	72-75	sonic hedgehog	Mus musculus	360-363
22046349-4	2011	Our data indicate that the TLR3 ligand polyinosinic-polycytidylic acid (PIC) negatively regulates NPC proliferation by inhibiting Sonic Hedgehog (Shh) signaling, that PIC induces apoptosis in association with inhibition of Ras-ERK signaling and elevated expression of Fas, and that these effects are TLR3-dependent, suggesting convergent signaling between the Shh and TLR3 pathways.	Poly I-C	72-75	toll-like receptor 3	Mus musculus	300-304
21912648-7	2011	At the same time, poly I:C induced HLA-DR up-regulation on MDC was reduced in HIV+ persons when compared to controls.	Poly I-C	18-26	C-C motif chemokine ligand 22	Homo sapiens	59-62
21674051-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: We report that polyinosinic:polycytidylic acid (PolyIC, synthetic analogue of dsRNA) induces dramatic apoptosis of mouse splenic conventional DC (cDC) in vivo, predominantly affecting the CD8alpha subset, as shown by flow cytometry-based analysis of splenic DC subsets.	Poly I-C	80-86	CD8 antigen, alpha chain	Mus musculus	220-228
21931631-9	2011	Using a microarray-derived gene expression signature of TBK1 in response virus infection or poly(I:C) stimulation, we found that TBK1 activation was strictly dependent on the integrity of the TBK1/TANK interaction.	Poly I-C	92-101	TANK binding kinase 1	Homo sapiens	129-133
21931631-9	2011	Using a microarray-derived gene expression signature of TBK1 in response virus infection or poly(I:C) stimulation, we found that TBK1 activation was strictly dependent on the integrity of the TBK1/TANK interaction.	Poly I-C	92-101	TANK binding kinase 1	Homo sapiens	129-133
20932985-5	2011	In hTERT-transfected HNECs, treatment with poly(I:C) significantly reduced expression of the tight junction protein JAM-A and induced secretion of proinflammatory cytokines IL-8 and TNF-alpha.	Poly I-C	43-51	telomerase reverse transcriptase	Homo sapiens	3-8
20932985-5	2011	In hTERT-transfected HNECs, treatment with poly(I:C) significantly reduced expression of the tight junction protein JAM-A and induced secretion of proinflammatory cytokines IL-8 and TNF-alpha.	Poly I-C	43-51	F11 receptor	Homo sapiens	116-121
20932985-5	2011	In hTERT-transfected HNECs, treatment with poly(I:C) significantly reduced expression of the tight junction protein JAM-A and induced secretion of proinflammatory cytokines IL-8 and TNF-alpha.	Poly I-C	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
20932985-5	2011	In hTERT-transfected HNECs, treatment with poly(I:C) significantly reduced expression of the tight junction protein JAM-A and induced secretion of proinflammatory cytokines IL-8 and TNF-alpha.	Poly I-C	43-51	tumor necrosis factor	Homo sapiens	182-191
20930504-1	2010	Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	0-31	toll like receptor 3	Homo sapiens	125-128
20930504-1	2010	Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	0-31	DExD/H-box helicase 58	Homo sapiens	136-166
20930504-1	2010	Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	0-31	DExD/H-box helicase 58	Homo sapiens	168-173
20930504-1	2010	Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	0-31	DExD/H-box helicase 58	Homo sapiens	208-213
20930504-1	2010	Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	0-31	interferon induced with helicase C domain 1	Homo sapiens	218-260
20930504-1	2010	Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	0-31	interferon induced with helicase C domain 1	Homo sapiens	262-266
20930504-1	2010	Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	33-40	toll like receptor 3	Homo sapiens	125-128
20930504-1	2010	Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	33-40	DExD/H-box helicase 58	Homo sapiens	136-166
20930504-1	2010	Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	33-40	DExD/H-box helicase 58	Homo sapiens	168-173
20930504-1	2010	Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	33-40	DExD/H-box helicase 58	Homo sapiens	208-213
20930504-1	2010	Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	33-40	interferon induced with helicase C domain 1	Homo sapiens	218-260
20930504-1	2010	Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	33-40	interferon induced with helicase C domain 1	Homo sapiens	262-266
20930504-4	2010	Recent studies have also shown that activation of TLR3 and RLR signaling by polyi:c can directly trigger apoptosis in some cancer cells.	Poly I-C	76-83	toll like receptor 3	Homo sapiens	50-54
20947153-13	2010	Activated EP3 was expressed in control CE cells, and it suppressed polyI:C-stimulated cytokine production, suggesting that EP3 might help prevent ocular surface inflammation.	Poly I-C	67-74	prostaglandin E receptor 3	Homo sapiens	10-13
21084665-6	2010	Furthermore, either IFN or poly-IC induces phosphorylation and cytoplasmic-to-nuclear translocation of IRF3, which seems essential for its function in that phosphomimic active IRF3 exhibits stronger transactivation than wild type IRF3.	Poly I-C	27-34	interferon regulatory factor 3	Homo sapiens	103-107
21084665-6	2010	Furthermore, either IFN or poly-IC induces phosphorylation and cytoplasmic-to-nuclear translocation of IRF3, which seems essential for its function in that phosphomimic active IRF3 exhibits stronger transactivation than wild type IRF3.	Poly I-C	27-34	interferon regulatory factor 3	Homo sapiens	176-180
21084665-6	2010	Furthermore, either IFN or poly-IC induces phosphorylation and cytoplasmic-to-nuclear translocation of IRF3, which seems essential for its function in that phosphomimic active IRF3 exhibits stronger transactivation than wild type IRF3.	Poly I-C	27-34	interferon regulatory factor 3	Homo sapiens	176-180
21068409-5	2010	We also found that expression of miR-101 is induced by multiple TLR ligands, including LPS, peptidoglycan, or polyinosinic-polycytidylic acid, and that inhibition of PI3K/Akt by LY294002 or Akt RNA interference blocks the induction of miR-101 by LPS in RAW264.7 macrophage cells.	Poly I-C	110-141	microRNA 101a	Mus musculus	33-40
20692254-5	2010	Activation of TLR3 by the synthetic RNA analogue polyinosinic-polycytidylic acid (poly(I:C)) in CRL2018 VSMC and in mice led to induction of CLU mRNA and protein synthesis, respectively.	Poly I-C	49-80	toll-like receptor 3	Mus musculus	14-18
20692254-5	2010	Activation of TLR3 by the synthetic RNA analogue polyinosinic-polycytidylic acid (poly(I:C)) in CRL2018 VSMC and in mice led to induction of CLU mRNA and protein synthesis, respectively.	Poly I-C	49-80	clusterin	Mus musculus	141-144
20692254-5	2010	Activation of TLR3 by the synthetic RNA analogue polyinosinic-polycytidylic acid (poly(I:C)) in CRL2018 VSMC and in mice led to induction of CLU mRNA and protein synthesis, respectively.	Poly I-C	82-91	toll-like receptor 3	Mus musculus	14-18
20692254-5	2010	Activation of TLR3 by the synthetic RNA analogue polyinosinic-polycytidylic acid (poly(I:C)) in CRL2018 VSMC and in mice led to induction of CLU mRNA and protein synthesis, respectively.	Poly I-C	82-91	clusterin	Mus musculus	141-144
20692254-6	2010	In TLR3-deficient 10A yolk sac cells, induction of CLU by poly(I:C) challenge depended on the ectopic expression of human TLR3.	Poly I-C	58-67	clusterin	Homo sapiens	51-54
20692254-6	2010	In TLR3-deficient 10A yolk sac cells, induction of CLU by poly(I:C) challenge depended on the ectopic expression of human TLR3.	Poly I-C	58-67	toll like receptor 3	Homo sapiens	3-7
20971743-6	2010	Treatment of HCC mice with polyinosinic-polycytidylic acid [poly(I:C)], a TLR3 agonist, led to both a reduction of tumor liver enlargement and a decrease in hepatic arterial blood flow, indicating that TLR3 is functional and may mediate both anti-angiogenic and anti-tumor responses.	Poly I-C	27-58	toll-like receptor 3	Mus musculus	74-78
20971743-6	2010	Treatment of HCC mice with polyinosinic-polycytidylic acid [poly(I:C)], a TLR3 agonist, led to both a reduction of tumor liver enlargement and a decrease in hepatic arterial blood flow, indicating that TLR3 is functional and may mediate both anti-angiogenic and anti-tumor responses.	Poly I-C	27-58	toll-like receptor 3	Mus musculus	202-206
20971743-6	2010	Treatment of HCC mice with polyinosinic-polycytidylic acid [poly(I:C)], a TLR3 agonist, led to both a reduction of tumor liver enlargement and a decrease in hepatic arterial blood flow, indicating that TLR3 is functional and may mediate both anti-angiogenic and anti-tumor responses.	Poly I-C	60-69	toll-like receptor 3	Mus musculus	74-78
20971743-6	2010	Treatment of HCC mice with polyinosinic-polycytidylic acid [poly(I:C)], a TLR3 agonist, led to both a reduction of tumor liver enlargement and a decrease in hepatic arterial blood flow, indicating that TLR3 is functional and may mediate both anti-angiogenic and anti-tumor responses.	Poly I-C	60-69	toll-like receptor 3	Mus musculus	202-206
20947153-13	2010	Activated EP3 was expressed in control CE cells, and it suppressed polyI:C-stimulated cytokine production, suggesting that EP3 might help prevent ocular surface inflammation.	Poly I-C	67-74	prostaglandin E receptor 3	Homo sapiens	123-126
20971925-4	2010	Treatment with a Cox-2 selective inhibitor (SC-58125) or Cox-2 small interfering RNA attenuated hBD2 and hBD3 production in NHEKs when stimulated with macrophage-activating lipopeptide-2, polyinosinic-polycytidylic acid, or UVB (15 mJ/cm(2)), but it did not attenuate vitamin D3-induced cathelicidin.	Poly I-C	188-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
20980632-4	2010	In vivo administration of CpG, polyinosinic-polycytidylic acid, and Pam(3)CSK(4) in combination with Ag resulted in the increased expression of costimulatory molecules and MHC class II by DCs, increased serum levels of the inflammatory cytokines IL-6 and RANTES, and increased cognate CD4 T cell responses in young and aged mice.	Poly I-C	31-62	interleukin 6	Mus musculus	246-250
20971925-3	2010	Normal human keratinocytes (NHEKs) stimulated with a TLR2/6 ligand, macrophage-activating lipopeptide-2, or a TLR3 ligand, polyinosinic-polycytidylic acid, increased Cox-2 mRNA and protein and increased PGE(2), a product of Cox-2.	Poly I-C	123-154	toll like receptor 3	Homo sapiens	110-114
20971925-3	2010	Normal human keratinocytes (NHEKs) stimulated with a TLR2/6 ligand, macrophage-activating lipopeptide-2, or a TLR3 ligand, polyinosinic-polycytidylic acid, increased Cox-2 mRNA and protein and increased PGE(2), a product of Cox-2.	Poly I-C	123-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
20971925-3	2010	Normal human keratinocytes (NHEKs) stimulated with a TLR2/6 ligand, macrophage-activating lipopeptide-2, or a TLR3 ligand, polyinosinic-polycytidylic acid, increased Cox-2 mRNA and protein and increased PGE(2), a product of Cox-2.	Poly I-C	123-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
20980632-4	2010	In vivo administration of CpG, polyinosinic-polycytidylic acid, and Pam(3)CSK(4) in combination with Ag resulted in the increased expression of costimulatory molecules and MHC class II by DCs, increased serum levels of the inflammatory cytokines IL-6 and RANTES, and increased cognate CD4 T cell responses in young and aged mice.	Poly I-C	31-62	chemokine (C-C motif) ligand 5	Mus musculus	255-261
20980632-4	2010	In vivo administration of CpG, polyinosinic-polycytidylic acid, and Pam(3)CSK(4) in combination with Ag resulted in the increased expression of costimulatory molecules and MHC class II by DCs, increased serum levels of the inflammatory cytokines IL-6 and RANTES, and increased cognate CD4 T cell responses in young and aged mice.	Poly I-C	31-62	CD4 antigen	Mus musculus	285-288
21123556-4	2010	To investigate this issue, we established a new model of brain inflammation by injecting the Toll-like receptor 3 (TLR-3) agonist polyinosinic:polycytidylic acid [poly(I:C)] in the SN of adult rats.	Poly I-C	130-161	toll-like receptor 3	Rattus norvegicus	93-113
21123556-4	2010	To investigate this issue, we established a new model of brain inflammation by injecting the Toll-like receptor 3 (TLR-3) agonist polyinosinic:polycytidylic acid [poly(I:C)] in the SN of adult rats.	Poly I-C	130-161	toll-like receptor 3	Rattus norvegicus	115-120
20975040-3	2010	We demonstrate that poly IC injection in vivo induces large amounts of IFN-lambda, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes.	Poly I-C	20-27	interferon alpha 1	Homo sapiens	71-74
20975040-3	2010	We demonstrate that poly IC injection in vivo induces large amounts of IFN-lambda, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes.	Poly I-C	20-27	toll like receptor 3	Homo sapiens	141-145
21059856-3	2010	Co-culture of mDC pretreated with the TLR3 ligand polyI:C and natural killer (NK) cells resulted in NK cell activation.	Poly I-C	50-57	chemokine (C-C motif) ligand 22	Mus musculus	14-17
21059856-3	2010	Co-culture of mDC pretreated with the TLR3 ligand polyI:C and natural killer (NK) cells resulted in NK cell activation.	Poly I-C	50-57	toll-like receptor 3	Mus musculus	38-42
20975040-3	2010	We demonstrate that poly IC injection in vivo induces large amounts of IFN-lambda, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes.	Poly I-C	20-27	toll like receptor 3	Homo sapiens	147-167
20975040-3	2010	We demonstrate that poly IC injection in vivo induces large amounts of IFN-lambda, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes.	Poly I-C	20-27	interferon regulatory factor 3	Homo sapiens	170-174
20975040-3	2010	We demonstrate that poly IC injection in vivo induces large amounts of IFN-lambda, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes.	Poly I-C	20-27	interferon regulatory factor 3	Homo sapiens	176-199
20975040-3	2010	We demonstrate that poly IC injection in vivo induces large amounts of IFN-lambda, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes.	Poly I-C	20-27	interferon regulatory factor 7	Homo sapiens	202-206
20975040-3	2010	We demonstrate that poly IC injection in vivo induces large amounts of IFN-lambda, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes.	Poly I-C	20-27	fms related receptor tyrosine kinase 3 ligand	Homo sapiens	208-260
20975040-3	2010	We demonstrate that poly IC injection in vivo induces large amounts of IFN-lambda, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes.	Poly I-C	20-27	interferon regulatory factor 8	Homo sapiens	271-275
20975040-3	2010	We demonstrate that poly IC injection in vivo induces large amounts of IFN-lambda, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes.	Poly I-C	20-27	MYD88 innate immune signal transduction adaptor	Homo sapiens	287-292
20975040-3	2010	We demonstrate that poly IC injection in vivo induces large amounts of IFN-lambda, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes.	Poly I-C	20-27	MYD88 innate immune signal transduction adaptor	Homo sapiens	294-327
20971108-3	2010	We show here that transfection of the dsRNA analogue poly I:C activates the NLRP3 inflammasome via a pathway requiring endosomal acidification.	Poly I-C	53-61	NLR family pyrin domain containing 3	Homo sapiens	76-81
20975040-3	2010	We demonstrate that poly IC injection in vivo induces large amounts of IFN-lambda, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes.	Poly I-C	20-27	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	330-333
20975040-4	2010	Upon poly IC injection in vivo, the IFN-lambda production by splenocytes segregated with cells phenotypically resembling CD8alpha(+) conventional dendritic cells (DCs [cDCs]).	Poly I-C	5-12	interferon alpha 1	Homo sapiens	36-39
20975040-4	2010	Upon poly IC injection in vivo, the IFN-lambda production by splenocytes segregated with cells phenotypically resembling CD8alpha(+) conventional dendritic cells (DCs [cDCs]).	Poly I-C	5-12	CD8a molecule	Homo sapiens	121-129
20657019-1	2010	BACKGROUND: The authors previously reported that human ocular surface epithelium expressed TLR3 and that its ligand polyI:C stimulated the secretion of IL-6, IL-8 and IFN-beta.	Poly I-C	116-123	toll like receptor 3	Homo sapiens	91-95
20943997-5	2010	Along these lines, the TLR3/MDA5 ligand polyinosinic-polycytidylic acid [poly(I:C)] has already been used to treat viral infections.	Poly I-C	40-71	toll-like receptor 3	Mus musculus	23-27
20943997-5	2010	Along these lines, the TLR3/MDA5 ligand polyinosinic-polycytidylic acid [poly(I:C)] has already been used to treat viral infections.	Poly I-C	40-71	interferon induced with helicase C domain 1	Mus musculus	28-32
20943997-5	2010	Along these lines, the TLR3/MDA5 ligand polyinosinic-polycytidylic acid [poly(I:C)] has already been used to treat viral infections.	Poly I-C	73-82	toll-like receptor 3	Mus musculus	23-27
20943997-5	2010	Along these lines, the TLR3/MDA5 ligand polyinosinic-polycytidylic acid [poly(I:C)] has already been used to treat viral infections.	Poly I-C	73-82	interferon induced with helicase C domain 1	Mus musculus	28-32
20657019-1	2010	BACKGROUND: The authors previously reported that human ocular surface epithelium expressed TLR3 and that its ligand polyI:C stimulated the secretion of IL-6, IL-8 and IFN-beta.	Poly I-C	116-123	interleukin 6	Homo sapiens	152-156
20657019-1	2010	BACKGROUND: The authors previously reported that human ocular surface epithelium expressed TLR3 and that its ligand polyI:C stimulated the secretion of IL-6, IL-8 and IFN-beta.	Poly I-C	116-123	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
20657019-1	2010	BACKGROUND: The authors previously reported that human ocular surface epithelium expressed TLR3 and that its ligand polyI:C stimulated the secretion of IL-6, IL-8 and IFN-beta.	Poly I-C	116-123	interferon beta 1	Homo sapiens	167-175
20685081-2	2010	We have previously shown that TLR-3 ligation on cultured non-neoplastic salivary gland epithelial cells (SGEC) with polyI:C (a synthetic analogue of viral dsRNA) results in the induction of surface immunoactive molecules, however, the pro-apoptotic effect of such signaling has not been addressed.	Poly I-C	116-123	toll like receptor 3	Homo sapiens	30-35
20957750-9	2010	Our findings offer a new mechanistic insight into TLR3/TRIF signalling through a hitherto unknown mechanism whereby Mal inhibits poly(I:C)-induced IRF7 activation and concomitant IFN-beta production.	Poly I-C	129-138	toll like receptor 3	Homo sapiens	50-54
20957750-9	2010	Our findings offer a new mechanistic insight into TLR3/TRIF signalling through a hitherto unknown mechanism whereby Mal inhibits poly(I:C)-induced IRF7 activation and concomitant IFN-beta production.	Poly I-C	129-138	TIR domain containing adaptor molecule 1	Homo sapiens	55-59
20957750-9	2010	Our findings offer a new mechanistic insight into TLR3/TRIF signalling through a hitherto unknown mechanism whereby Mal inhibits poly(I:C)-induced IRF7 activation and concomitant IFN-beta production.	Poly I-C	129-138	mal, T cell differentiation protein	Homo sapiens	116-119
20957750-9	2010	Our findings offer a new mechanistic insight into TLR3/TRIF signalling through a hitherto unknown mechanism whereby Mal inhibits poly(I:C)-induced IRF7 activation and concomitant IFN-beta production.	Poly I-C	129-138	interferon regulatory factor 7	Homo sapiens	147-151
20957750-9	2010	Our findings offer a new mechanistic insight into TLR3/TRIF signalling through a hitherto unknown mechanism whereby Mal inhibits poly(I:C)-induced IRF7 activation and concomitant IFN-beta production.	Poly I-C	129-138	interferon beta 1	Homo sapiens	179-187
20935541-10	2010	Poly I:C induced expression of TSLP in cultured conjunctival epithelial cells at mRNA level.	Poly I-C	0-8	thymic stromal lymphopoietin	Homo sapiens	31-35
20574012-0	2010	Poly(I:C)-induced adhesion molecule expression mediated by NF-{kappa}B and phosphoinositide 3-kinase-Akt signaling pathways in human corneal fibroblasts.	Poly I-C	0-8	nuclear factor kappa B subunit 1	Homo sapiens	59-70
20574012-0	2010	Poly(I:C)-induced adhesion molecule expression mediated by NF-{kappa}B and phosphoinositide 3-kinase-Akt signaling pathways in human corneal fibroblasts.	Poly I-C	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	75-100
20574012-0	2010	Poly(I:C)-induced adhesion molecule expression mediated by NF-{kappa}B and phosphoinositide 3-kinase-Akt signaling pathways in human corneal fibroblasts.	Poly I-C	0-8	AKT serine/threonine kinase 1	Homo sapiens	101-104
20574012-8	2010	Poly(I:C) also induced the phosphorylation of IkappaB-alpha and Akt.	Poly I-C	0-8	NFKB inhibitor alpha	Homo sapiens	46-59
20574012-8	2010	Poly(I:C) also induced the phosphorylation of IkappaB-alpha and Akt.	Poly I-C	0-8	AKT serine/threonine kinase 1	Homo sapiens	64-67
20574012-9	2010	The poly(I:C)-induced expression of VCAM-1 and ICAM-1 was attenuated by both IKK2 inhibitor and LY294002.	Poly I-C	4-12	vascular cell adhesion molecule 1	Homo sapiens	36-42
20574012-9	2010	The poly(I:C)-induced expression of VCAM-1 and ICAM-1 was attenuated by both IKK2 inhibitor and LY294002.	Poly I-C	4-12	intercellular adhesion molecule 1	Homo sapiens	47-53
20685081-4	2010	PolyI:C-induced anoikis in SGEC was associated with the upregulation of the pro-apoptotic Bmf, BimEL and Bax and the down-regulation of the pro-survival Bcl-2 (real-time PCR analyses).	Poly I-C	0-7	Bcl2 modifying factor	Homo sapiens	90-93
20574012-9	2010	The poly(I:C)-induced expression of VCAM-1 and ICAM-1 was attenuated by both IKK2 inhibitor and LY294002.	Poly I-C	4-12	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	77-81
20685081-4	2010	PolyI:C-induced anoikis in SGEC was associated with the upregulation of the pro-apoptotic Bmf, BimEL and Bax and the down-regulation of the pro-survival Bcl-2 (real-time PCR analyses).	Poly I-C	0-7	BCL2 associated X, apoptosis regulator	Homo sapiens	105-108
20574012-10	2010	CONCLUSIONS: The NF-kappaB and PI3K-Akt signaling pathways mediate the poly(I:C)-induced upregulation of VCAM-1 and ICAM-1 in corneal fibroblasts, with PI3K acting upstream of NF-kappaB activation.	Poly I-C	71-80	AKT serine/threonine kinase 1	Homo sapiens	36-39
20574012-10	2010	CONCLUSIONS: The NF-kappaB and PI3K-Akt signaling pathways mediate the poly(I:C)-induced upregulation of VCAM-1 and ICAM-1 in corneal fibroblasts, with PI3K acting upstream of NF-kappaB activation.	Poly I-C	71-80	vascular cell adhesion molecule 1	Homo sapiens	105-111
20685081-4	2010	PolyI:C-induced anoikis in SGEC was associated with the upregulation of the pro-apoptotic Bmf, BimEL and Bax and the down-regulation of the pro-survival Bcl-2 (real-time PCR analyses).	Poly I-C	0-7	BCL2 apoptosis regulator	Homo sapiens	153-158
20574012-10	2010	CONCLUSIONS: The NF-kappaB and PI3K-Akt signaling pathways mediate the poly(I:C)-induced upregulation of VCAM-1 and ICAM-1 in corneal fibroblasts, with PI3K acting upstream of NF-kappaB activation.	Poly I-C	71-80	intercellular adhesion molecule 1	Homo sapiens	116-122
20613770-6	2010	Of the TLRs ligands tested, the TLR3 ligand, polyinosinic/polycytidylic acid (Poly(I:C)), most highly increased fibroblast expression of both IFN- and TGFbeta-responsive genes as well as TLR3.	Poly I-C	45-76	toll-like receptor 3	Mus musculus	32-36
20613770-6	2010	Of the TLRs ligands tested, the TLR3 ligand, polyinosinic/polycytidylic acid (Poly(I:C)), most highly increased fibroblast expression of both IFN- and TGFbeta-responsive genes as well as TLR3.	Poly I-C	45-76	transforming growth factor, beta 1	Mus musculus	151-158
20456615-9	2010	IL-6 and IL-8 production was increased by Pam(3) CSK(4) , flagellin, Poly I:C, and imiquimod, but not lipopolysaccharide (LPS).	Poly I-C	69-77	interleukin 6	Homo sapiens	0-4
20613770-6	2010	Of the TLRs ligands tested, the TLR3 ligand, polyinosinic/polycytidylic acid (Poly(I:C)), most highly increased fibroblast expression of both IFN- and TGFbeta-responsive genes as well as TLR3.	Poly I-C	45-76	toll-like receptor 3	Mus musculus	187-191
20613770-6	2010	Of the TLRs ligands tested, the TLR3 ligand, polyinosinic/polycytidylic acid (Poly(I:C)), most highly increased fibroblast expression of both IFN- and TGFbeta-responsive genes as well as TLR3.	Poly I-C	78-86	toll-like receptor 3	Mus musculus	32-36
20613770-6	2010	Of the TLRs ligands tested, the TLR3 ligand, polyinosinic/polycytidylic acid (Poly(I:C)), most highly increased fibroblast expression of both IFN- and TGFbeta-responsive genes as well as TLR3.	Poly I-C	78-86	transforming growth factor, beta 1	Mus musculus	151-158
20613770-6	2010	Of the TLRs ligands tested, the TLR3 ligand, polyinosinic/polycytidylic acid (Poly(I:C)), most highly increased fibroblast expression of both IFN- and TGFbeta-responsive genes as well as TLR3.	Poly I-C	78-86	toll-like receptor 3	Mus musculus	187-191
20836715-5	2010	Since Akt is a critical downstream regulator of PI3K, we investigated the phosphorylation status of Akt in M-SMCs after treatment with poly I:C for 1 h and found that Akt was phosphorylated, but the phosphorylated Akt band was undetectable in LY294002 plus poly I:C-treated cultures.	Poly I-C	135-143	AKT serine/threonine kinase 1	Homo sapiens	6-9
20836715-5	2010	Since Akt is a critical downstream regulator of PI3K, we investigated the phosphorylation status of Akt in M-SMCs after treatment with poly I:C for 1 h and found that Akt was phosphorylated, but the phosphorylated Akt band was undetectable in LY294002 plus poly I:C-treated cultures.	Poly I-C	135-143	AKT serine/threonine kinase 1	Homo sapiens	100-103
20836715-5	2010	Since Akt is a critical downstream regulator of PI3K, we investigated the phosphorylation status of Akt in M-SMCs after treatment with poly I:C for 1 h and found that Akt was phosphorylated, but the phosphorylated Akt band was undetectable in LY294002 plus poly I:C-treated cultures.	Poly I-C	135-143	AKT serine/threonine kinase 1	Homo sapiens	100-103
20836715-5	2010	Since Akt is a critical downstream regulator of PI3K, we investigated the phosphorylation status of Akt in M-SMCs after treatment with poly I:C for 1 h and found that Akt was phosphorylated, but the phosphorylated Akt band was undetectable in LY294002 plus poly I:C-treated cultures.	Poly I-C	135-143	AKT serine/threonine kinase 1	Homo sapiens	100-103
20836715-5	2010	Since Akt is a critical downstream regulator of PI3K, we investigated the phosphorylation status of Akt in M-SMCs after treatment with poly I:C for 1 h and found that Akt was phosphorylated, but the phosphorylated Akt band was undetectable in LY294002 plus poly I:C-treated cultures.	Poly I-C	257-265	AKT serine/threonine kinase 1	Homo sapiens	6-9
20836715-5	2010	Since Akt is a critical downstream regulator of PI3K, we investigated the phosphorylation status of Akt in M-SMCs after treatment with poly I:C for 1 h and found that Akt was phosphorylated, but the phosphorylated Akt band was undetectable in LY294002 plus poly I:C-treated cultures.	Poly I-C	257-265	AKT serine/threonine kinase 1	Homo sapiens	100-103
20836715-5	2010	Since Akt is a critical downstream regulator of PI3K, we investigated the phosphorylation status of Akt in M-SMCs after treatment with poly I:C for 1 h and found that Akt was phosphorylated, but the phosphorylated Akt band was undetectable in LY294002 plus poly I:C-treated cultures.	Poly I-C	257-265	AKT serine/threonine kinase 1	Homo sapiens	100-103
20836715-5	2010	Since Akt is a critical downstream regulator of PI3K, we investigated the phosphorylation status of Akt in M-SMCs after treatment with poly I:C for 1 h and found that Akt was phosphorylated, but the phosphorylated Akt band was undetectable in LY294002 plus poly I:C-treated cultures.	Poly I-C	257-265	AKT serine/threonine kinase 1	Homo sapiens	100-103
20456615-9	2010	IL-6 and IL-8 production was increased by Pam(3) CSK(4) , flagellin, Poly I:C, and imiquimod, but not lipopolysaccharide (LPS).	Poly I-C	69-77	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
20728939-5	2010	Furthermore, we provide evidence that Poly I:C induced expression of IL-1beta, TNFalpha, IL-12p70 and IFN-beta was blocked by JNK inhibitor SP600125.	Poly I-C	38-46	interleukin 1 beta	Homo sapiens	69-77
20728939-5	2010	Furthermore, we provide evidence that Poly I:C induced expression of IL-1beta, TNFalpha, IL-12p70 and IFN-beta was blocked by JNK inhibitor SP600125.	Poly I-C	38-46	tumor necrosis factor	Homo sapiens	79-87
20728939-5	2010	Furthermore, we provide evidence that Poly I:C induced expression of IL-1beta, TNFalpha, IL-12p70 and IFN-beta was blocked by JNK inhibitor SP600125.	Poly I-C	38-46	interferon beta 1	Homo sapiens	102-110
20728939-5	2010	Furthermore, we provide evidence that Poly I:C induced expression of IL-1beta, TNFalpha, IL-12p70 and IFN-beta was blocked by JNK inhibitor SP600125.	Poly I-C	38-46	mitogen-activated protein kinase 8	Homo sapiens	126-129
20692306-5	2010	The obtained results showed that PRRSV nsp1 could inhibit Poly(I:C)-induced IFN-beta promoter activity in MARC-145 cells by down-regulating the protein level of IRF-3 and inhibiting the phosphorylation of IRF-3.	Poly I-C	58-67	interferon beta 1	Sus scrofa	76-84
20846528-0	2010	Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and alphaDEC-CSP in non human primates.	Poly I-C	0-8	DnaJ heat shock protein family (Hsp40) member C5	Mus musculus	142-145
20846528-0	2010	Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and alphaDEC-CSP in non human primates.	Poly I-C	0-8	DnaJ heat shock protein family (Hsp40) member C5	Mus musculus	160-163
20685307-10	2010	Specifically, poly I:C elicited the largest increases in interleukin (IL)-1beta mRNA in the liver, spleen, and hippocampus.	Poly I-C	14-22	interleukin-1 beta	Sus scrofa	57-79
20610559-7	2010	Plasma concentrations of interferon-gamma, tumor necrosis factor-alpha, and interleukin-6 were significantly induced in poly(I:C)-treated rats, compared with controls (p < 0.001).	Poly I-C	120-129	interferon gamma	Rattus norvegicus	25-70
20610559-7	2010	Plasma concentrations of interferon-gamma, tumor necrosis factor-alpha, and interleukin-6 were significantly induced in poly(I:C)-treated rats, compared with controls (p < 0.001).	Poly I-C	120-129	interleukin 6	Rattus norvegicus	76-89
20435591-6	2010	The poly(I:C)-induced expression of MMP-1 and MMP-3 was attenuated by a synthetic inhibitor of NF-kappaB signaling and by IL-1 receptor antagonist; the latter also inhibited poly(I:C)-induced phosphorylation of IkappaB-alpha.	Poly I-C	4-12	matrix metallopeptidase 1	Homo sapiens	36-41
20435591-6	2010	The poly(I:C)-induced expression of MMP-1 and MMP-3 was attenuated by a synthetic inhibitor of NF-kappaB signaling and by IL-1 receptor antagonist; the latter also inhibited poly(I:C)-induced phosphorylation of IkappaB-alpha.	Poly I-C	4-12	matrix metallopeptidase 3	Homo sapiens	46-51
20435591-6	2010	The poly(I:C)-induced expression of MMP-1 and MMP-3 was attenuated by a synthetic inhibitor of NF-kappaB signaling and by IL-1 receptor antagonist; the latter also inhibited poly(I:C)-induced phosphorylation of IkappaB-alpha.	Poly I-C	4-12	nuclear factor kappa B subunit 1	Homo sapiens	95-104
20435591-6	2010	The poly(I:C)-induced expression of MMP-1 and MMP-3 was attenuated by a synthetic inhibitor of NF-kappaB signaling and by IL-1 receptor antagonist; the latter also inhibited poly(I:C)-induced phosphorylation of IkappaB-alpha.	Poly I-C	4-12	interleukin 1 receptor antagonist	Homo sapiens	122-146
20435591-6	2010	The poly(I:C)-induced expression of MMP-1 and MMP-3 was attenuated by a synthetic inhibitor of NF-kappaB signaling and by IL-1 receptor antagonist; the latter also inhibited poly(I:C)-induced phosphorylation of IkappaB-alpha.	Poly I-C	4-12	NFKB inhibitor alpha	Homo sapiens	211-224
20435591-6	2010	The poly(I:C)-induced expression of MMP-1 and MMP-3 was attenuated by a synthetic inhibitor of NF-kappaB signaling and by IL-1 receptor antagonist; the latter also inhibited poly(I:C)-induced phosphorylation of IkappaB-alpha.	Poly I-C	4-13	matrix metallopeptidase 1	Homo sapiens	36-41
20435591-6	2010	The poly(I:C)-induced expression of MMP-1 and MMP-3 was attenuated by a synthetic inhibitor of NF-kappaB signaling and by IL-1 receptor antagonist; the latter also inhibited poly(I:C)-induced phosphorylation of IkappaB-alpha.	Poly I-C	4-13	matrix metallopeptidase 3	Homo sapiens	46-51
20435591-6	2010	The poly(I:C)-induced expression of MMP-1 and MMP-3 was attenuated by a synthetic inhibitor of NF-kappaB signaling and by IL-1 receptor antagonist; the latter also inhibited poly(I:C)-induced phosphorylation of IkappaB-alpha.	Poly I-C	4-13	nuclear factor kappa B subunit 1	Homo sapiens	95-104
20435591-6	2010	The poly(I:C)-induced expression of MMP-1 and MMP-3 was attenuated by a synthetic inhibitor of NF-kappaB signaling and by IL-1 receptor antagonist; the latter also inhibited poly(I:C)-induced phosphorylation of IkappaB-alpha.	Poly I-C	4-13	interleukin 1 receptor antagonist	Homo sapiens	122-146
20435591-6	2010	The poly(I:C)-induced expression of MMP-1 and MMP-3 was attenuated by a synthetic inhibitor of NF-kappaB signaling and by IL-1 receptor antagonist; the latter also inhibited poly(I:C)-induced phosphorylation of IkappaB-alpha.	Poly I-C	4-13	NFKB inhibitor alpha	Homo sapiens	211-224
20435591-7	2010	CONCLUSIONS: Poly(I:C) induces the expression of MMP-1 and MMP-3 in human corneal fibroblasts in a manner dependent on activation of the transcription factor NF-kappaB and on IL-1beta secretion.	Poly I-C	13-21	matrix metallopeptidase 1	Homo sapiens	49-54
20435591-7	2010	CONCLUSIONS: Poly(I:C) induces the expression of MMP-1 and MMP-3 in human corneal fibroblasts in a manner dependent on activation of the transcription factor NF-kappaB and on IL-1beta secretion.	Poly I-C	13-21	matrix metallopeptidase 3	Homo sapiens	59-64
20435591-7	2010	CONCLUSIONS: Poly(I:C) induces the expression of MMP-1 and MMP-3 in human corneal fibroblasts in a manner dependent on activation of the transcription factor NF-kappaB and on IL-1beta secretion.	Poly I-C	13-21	nuclear factor kappa B subunit 1	Homo sapiens	158-167
20435591-7	2010	CONCLUSIONS: Poly(I:C) induces the expression of MMP-1 and MMP-3 in human corneal fibroblasts in a manner dependent on activation of the transcription factor NF-kappaB and on IL-1beta secretion.	Poly I-C	13-21	interleukin 1 beta	Homo sapiens	175-183
20937230-0	2010	[Expression of TLR3 and IL-8, Eotaxin in the airway smooth muscle cells induced by PolyI:C].	Poly I-C	83-90	C-C motif chemokine ligand 11	Rattus norvegicus	30-37
20937230-1	2010	AIM: to observe the effect of PolyI:C on the expression of TLR3 and inflammation cytokine in the airway smooth muscle cells ASMCs of rat, to investigate relationship between the expression of Toll-like receptor 3 (TLR3) in the airway smooth muscle cells and airway inflammation.	Poly I-C	30-37	toll-like receptor 3	Rattus norvegicus	59-63
20937230-0	2010	[Expression of TLR3 and IL-8, Eotaxin in the airway smooth muscle cells induced by PolyI:C].	Poly I-C	83-90	toll-like receptor 3	Rattus norvegicus	15-19
20937230-6	2010	RESULTS: the expression of TLR3 mRNA and NF-kappaB protein in the ASMCs in PolyI:C group was significantly higher than those in control group(P<0.05), the concentration of IL-8 and Eotaxin in the ASMCs in PolyI:C group was significantly higher compared to control group (P<0.05); and have time dependent manner.	Poly I-C	75-82	toll-like receptor 3	Rattus norvegicus	27-31
20592090-8	2010	Induction of both IFN-beta and IFN-lambda1 in A549 cells after poly(I:C)-stimulation was strongly inhibited in HTNV-infected cells, suggesting that HTNV can inhibit signaling pathways used to simultaneously activate types I and III IFNs.	Poly I-C	63-72	interferon alpha 1	Homo sapiens	18-21
20937230-6	2010	RESULTS: the expression of TLR3 mRNA and NF-kappaB protein in the ASMCs in PolyI:C group was significantly higher than those in control group(P<0.05), the concentration of IL-8 and Eotaxin in the ASMCs in PolyI:C group was significantly higher compared to control group (P<0.05); and have time dependent manner.	Poly I-C	75-82	C-C motif chemokine ligand 11	Rattus norvegicus	184-191
20937230-6	2010	RESULTS: the expression of TLR3 mRNA and NF-kappaB protein in the ASMCs in PolyI:C group was significantly higher than those in control group(P<0.05), the concentration of IL-8 and Eotaxin in the ASMCs in PolyI:C group was significantly higher compared to control group (P<0.05); and have time dependent manner.	Poly I-C	208-215	toll-like receptor 3	Rattus norvegicus	27-31
20937230-7	2010	CONCLUSION: poly I:C promoted the expression of TLR3 in ASMCs, activated NF-kappaB, incresead the concentration of IL-8 and Eotaxin, involved in airway inflammation of asthma.	Poly I-C	12-20	toll-like receptor 3	Rattus norvegicus	48-52
20937230-7	2010	CONCLUSION: poly I:C promoted the expression of TLR3 in ASMCs, activated NF-kappaB, incresead the concentration of IL-8 and Eotaxin, involved in airway inflammation of asthma.	Poly I-C	12-20	C-C motif chemokine ligand 11	Rattus norvegicus	124-131
20549206-2	2010	In this study, we sought to determine critical roles of host IFN-alpha and IFN-gamma pathways in the enhanced therapeutic efficacy mediated by peptide vaccines and polyinosinic-polycytidylic acid [poly(I:C)] stabilized by lysine and carboxymethylcellulose (poly-ICLC) in the murine central nervous system (CNS) GL261 glioma.	Poly I-C	164-195	interferon gamma	Mus musculus	75-84
20413727-12	2010	A screen of other TLR ligands demonstrated that stimulation with poly I:C (dsRNA analog) also results in up-regulation of factor B, which is dependent on JNK and NF-kappaB but independent of TLR3 and TRIF.	Poly I-C	65-73	complement factor B	Mus musculus	122-130
20413727-12	2010	A screen of other TLR ligands demonstrated that stimulation with poly I:C (dsRNA analog) also results in up-regulation of factor B, which is dependent on JNK and NF-kappaB but independent of TLR3 and TRIF.	Poly I-C	65-73	mitogen-activated protein kinase 8	Mus musculus	154-157
20413727-12	2010	A screen of other TLR ligands demonstrated that stimulation with poly I:C (dsRNA analog) also results in up-regulation of factor B, which is dependent on JNK and NF-kappaB but independent of TLR3 and TRIF.	Poly I-C	65-73	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	162-171
20413727-12	2010	A screen of other TLR ligands demonstrated that stimulation with poly I:C (dsRNA analog) also results in up-regulation of factor B, which is dependent on JNK and NF-kappaB but independent of TLR3 and TRIF.	Poly I-C	65-73	toll-like receptor 3	Mus musculus	191-195
20413727-12	2010	A screen of other TLR ligands demonstrated that stimulation with poly I:C (dsRNA analog) also results in up-regulation of factor B, which is dependent on JNK and NF-kappaB but independent of TLR3 and TRIF.	Poly I-C	65-73	toll-like receptor adaptor molecule 2	Mus musculus	200-204
20592090-8	2010	Induction of both IFN-beta and IFN-lambda1 in A549 cells after poly(I:C)-stimulation was strongly inhibited in HTNV-infected cells, suggesting that HTNV can inhibit signaling pathways used to simultaneously activate types I and III IFNs.	Poly I-C	63-72	interferon alpha 1	Homo sapiens	31-34
20639488-5	2010	Poly(I:C) but not polyadenylic-polyuridylic acid synergized with mDC-derived IL-12 for IFN-gamma production by acting directly on NK cells.	Poly I-C	0-8	interferon gamma	Homo sapiens	87-96
20639488-2	2010	We show in this paper that two dsRNAs, polyadenylic-polyuridylic acid and polyinosinic-polycytidylic acid [poly(I:C)], similarly engaged human TLR3, whereas only poly(I:C) triggered human RIG-I and MDA5.	Poly I-C	74-105	toll like receptor 3	Homo sapiens	143-147
20576118-0	2010	Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells.	Poly I-C	0-8	baculoviral IAP repeat containing 3	Homo sapiens	40-46
20639488-2	2010	We show in this paper that two dsRNAs, polyadenylic-polyuridylic acid and polyinosinic-polycytidylic acid [poly(I:C)], similarly engaged human TLR3, whereas only poly(I:C) triggered human RIG-I and MDA5.	Poly I-C	74-105	interferon induced with helicase C domain 1	Homo sapiens	198-202
20639488-2	2010	We show in this paper that two dsRNAs, polyadenylic-polyuridylic acid and polyinosinic-polycytidylic acid [poly(I:C)], similarly engaged human TLR3, whereas only poly(I:C) triggered human RIG-I and MDA5.	Poly I-C	107-116	toll like receptor 3	Homo sapiens	143-147
20639488-2	2010	We show in this paper that two dsRNAs, polyadenylic-polyuridylic acid and polyinosinic-polycytidylic acid [poly(I:C)], similarly engaged human TLR3, whereas only poly(I:C) triggered human RIG-I and MDA5.	Poly I-C	107-116	DExD/H-box helicase 58	Homo sapiens	188-193
20639488-2	2010	We show in this paper that two dsRNAs, polyadenylic-polyuridylic acid and polyinosinic-polycytidylic acid [poly(I:C)], similarly engaged human TLR3, whereas only poly(I:C) triggered human RIG-I and MDA5.	Poly I-C	107-116	interferon induced with helicase C domain 1	Homo sapiens	198-202
20406302-3	2010	TRAIL expression was strongly induced in DCs upon stimulation with lipopolysaccharide (LPS) or Polyinosine-polycytidylic acid (poly(I:C)) stimulation.	Poly I-C	127-136	TNF superfamily member 10	Homo sapiens	0-5
20827338-8	2010	Poly(I:C)-induced increases of IP-10 and I-TAC were also confirmed at protein levels from cell lysates, but their release into extracellular medium was detected only in IP-10.	Poly I-C	0-8	C-X-C motif chemokine ligand 10	Homo sapiens	31-36
20827338-8	2010	Poly(I:C)-induced increases of IP-10 and I-TAC were also confirmed at protein levels from cell lysates, but their release into extracellular medium was detected only in IP-10.	Poly I-C	0-8	C-X-C motif chemokine ligand 11	Homo sapiens	41-46
20827338-8	2010	Poly(I:C)-induced increases of IP-10 and I-TAC were also confirmed at protein levels from cell lysates, but their release into extracellular medium was detected only in IP-10.	Poly I-C	0-8	C-X-C motif chemokine ligand 10	Homo sapiens	169-174
20543109-10	2010	In addition to a direct antiviral effect and synergism with IFN, the SOCS antagonist also exhibits adjuvant effects on humoral and cellular immunity as well as an enhancement of polyinosinic-polycytidylic acid activation of TLR3.	Poly I-C	178-209	cytokine inducible SH2 containing protein	Homo sapiens	69-73
20543109-10	2010	In addition to a direct antiviral effect and synergism with IFN, the SOCS antagonist also exhibits adjuvant effects on humoral and cellular immunity as well as an enhancement of polyinosinic-polycytidylic acid activation of TLR3.	Poly I-C	178-209	toll like receptor 3	Homo sapiens	224-228
20309865-3	2010	TLR-3 regulation and signaling were assessed in myoblasts and in differentiated myotubes with the TLR-3 agonist poly(I-C), necrotic myoblasts, and Th1 and Th17 cytokines, in the presence or absence of neutralizing anti-TLR-3 antibody.	Poly I-C	112-120	toll like receptor 3	Homo sapiens	0-5
20511546-3	2010	We show that mouse bone marrow-derived cultured MCs activated with LPS, polyinosinic-polycytidylic acid, or CpG can stimulate NK cells to secrete increasing concentrations of IFN-gamma.	Poly I-C	72-103	interferon gamma	Mus musculus	175-184
20651983-6	2010	However, the transfection of I.3 isoform of hif-1 alpha in LNCaP cells allows poly(I:C)-induced HIF-1 activation, resulting in apoptosis protection and VEGF secretion.	Poly I-C	78-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-55
20651983-6	2010	However, the transfection of I.3 isoform of hif-1 alpha in LNCaP cells allows poly(I:C)-induced HIF-1 activation, resulting in apoptosis protection and VEGF secretion.	Poly I-C	78-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-101
20651983-6	2010	However, the transfection of I.3 isoform of hif-1 alpha in LNCaP cells allows poly(I:C)-induced HIF-1 activation, resulting in apoptosis protection and VEGF secretion.	Poly I-C	78-87	vascular endothelial growth factor A	Homo sapiens	152-156
20514466-12	2010	Interestingly, the stimulation of TLR3 by poly I:C induced apoptosis in cancer cells in a dose-dependent manner.	Poly I-C	42-50	toll like receptor 3	Homo sapiens	34-38
20688601-8	2010	The NF-kappaB essential modifier-binding domain (NBD) inhibited the survival of activated CD4+ T cells induced by poly I:C and CpG DNA, but the AP-1 inhibitor crucumin did not have the same effect.	Poly I-C	114-122	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	4-13
20688601-9	2010	The increased expression of NF-kappaB induced by poly I:C and CpG DNA in activated CD4+ T cells could be inhibited by MP, but the same was not true for the increased expression of AP-1 induced by poly I:C and CpG DNA.	Poly I-C	49-57	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	28-37
20688601-9	2010	The increased expression of NF-kappaB induced by poly I:C and CpG DNA in activated CD4+ T cells could be inhibited by MP, but the same was not true for the increased expression of AP-1 induced by poly I:C and CpG DNA.	Poly I-C	196-204	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	28-37
20688601-9	2010	The increased expression of NF-kappaB induced by poly I:C and CpG DNA in activated CD4+ T cells could be inhibited by MP, but the same was not true for the increased expression of AP-1 induced by poly I:C and CpG DNA.	Poly I-C	196-204	jun proto-oncogene	Mus musculus	180-184
20627394-3	2010	Using transient transfection and recombinant protein, we are reporting in this study that a crucian carp (Carassius auratus L.) IFN exhibits strong antiviral activity against grass carp hemorrhagic virus (GCHV) infection and also mediates Poly I:C-induced antiviral response, which correlates with its ability to induce a set of IFN-stimulated genes (ISGs).	Poly I-C	239-247	interferon alpha 1	Homo sapiens	128-131
20448144-1	2010	Liver lymphocytes are enriched in natural killer (NK) cells, and activation of NK cells by injection of polyinosinic-polycytidylic acid (poly I:C) inhibits liver regeneration in the partial hepatectomy model via production of IFN-gamma.	Poly I-C	104-135	interferon gamma	Mus musculus	226-235
20448144-1	2010	Liver lymphocytes are enriched in natural killer (NK) cells, and activation of NK cells by injection of polyinosinic-polycytidylic acid (poly I:C) inhibits liver regeneration in the partial hepatectomy model via production of IFN-gamma.	Poly I-C	137-145	interferon gamma	Mus musculus	226-235
20448144-6	2010	Poly I:C and CCl(4) cotreatment synergistically induced accumulation of NK cells in the liver and NK cell production of IFN-gamma and tumor necrosis factor (TNF)-alpha.	Poly I-C	0-8	interferon gamma	Mus musculus	120-129
20448144-6	2010	Poly I:C and CCl(4) cotreatment synergistically induced accumulation of NK cells in the liver and NK cell production of IFN-gamma and tumor necrosis factor (TNF)-alpha.	Poly I-C	0-8	tumor necrosis factor	Mus musculus	134-167
20448144-8	2010	Finally, blockage of TNF-alpha but not IFN-gamma restored liver regeneration in poly I:C/CCl(4)-treated mice.	Poly I-C	80-88	tumor necrosis factor	Mus musculus	21-30
20448144-9	2010	Taken together, these findings suggest that poly I:C treatment inhibits liver regeneration in the CCl(4)-induced liver injury model via induction of NK cell production of TNF-alpha.	Poly I-C	44-52	tumor necrosis factor	Mus musculus	171-180
20367642-1	2010	Toll-like receptor 3 (TLR3) has gained recognition as a novel molecular target for cancer therapy because TLR3 activation by its synthetic ligand poly I:C directly causes tumor cell death.	Poly I-C	146-154	toll like receptor 3	Homo sapiens	0-20
20367642-1	2010	Toll-like receptor 3 (TLR3) has gained recognition as a novel molecular target for cancer therapy because TLR3 activation by its synthetic ligand poly I:C directly causes tumor cell death.	Poly I-C	146-154	toll like receptor 3	Homo sapiens	22-26
20367642-1	2010	Toll-like receptor 3 (TLR3) has gained recognition as a novel molecular target for cancer therapy because TLR3 activation by its synthetic ligand poly I:C directly causes tumor cell death.	Poly I-C	146-154	toll like receptor 3	Homo sapiens	106-110
20367642-4	2010	We thus hypothesized that various anticancer drugs such as p53-activating reagents and IFNs may potentiate poly I:C-induced tumor cell death through the up-regulation of TLR3 expression.	Poly I-C	107-115	tumor protein p53	Homo sapiens	59-62
20367642-4	2010	We thus hypothesized that various anticancer drugs such as p53-activating reagents and IFNs may potentiate poly I:C-induced tumor cell death through the up-regulation of TLR3 expression.	Poly I-C	107-115	toll like receptor 3	Homo sapiens	170-174
20367642-6	2010	We found that the DNA-damaging reagent 5-fluorouracil (5-FU) increased TLR3 mRNA expression and potentiated poly I:C-induced apoptosis in HCT116 p53(+/+) cells but had only minimal effect in p53(-/-) cells, indicating a p53-dependent pathway.	Poly I-C	108-116	tumor protein p53	Homo sapiens	145-148
20367642-8	2010	Furthermore, the combination of poly I:C, 5-FU and IFN-alpha induced the highest apoptosis in HCT116 p53(+/+) and p53(-/-) cells.	Poly I-C	32-40	tumor protein p53	Homo sapiens	101-104
20367642-8	2010	Furthermore, the combination of poly I:C, 5-FU and IFN-alpha induced the highest apoptosis in HCT116 p53(+/+) and p53(-/-) cells.	Poly I-C	32-40	tumor protein p53	Homo sapiens	114-117
20367642-9	2010	Taken together, these data suggest that the anticancer drugs increased TLR3 expression and subsequently potentiated poly I:C-induced apoptosis likely via p53-dependent and -independent pathways.	Poly I-C	116-124	toll like receptor 3	Homo sapiens	71-75
20367642-9	2010	Taken together, these data suggest that the anticancer drugs increased TLR3 expression and subsequently potentiated poly I:C-induced apoptosis likely via p53-dependent and -independent pathways.	Poly I-C	116-124	tumor protein p53	Homo sapiens	154-157
20462636-5	2010	Of the TLR ligands examined, lipopolysaccharide (LPS) and poly I:C were the most potent activators of MoDCs, inducing the up-regulation of co-stimulatory molecules CD80/86 and the chemokine receptor CCR7, and production of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)alpha.	Poly I-C	58-66	CD80 molecule	Homo sapiens	164-168
20462636-5	2010	Of the TLR ligands examined, lipopolysaccharide (LPS) and poly I:C were the most potent activators of MoDCs, inducing the up-regulation of co-stimulatory molecules CD80/86 and the chemokine receptor CCR7, and production of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)alpha.	Poly I-C	58-66	C-C motif chemokine receptor 7	Homo sapiens	199-203
20462636-5	2010	Of the TLR ligands examined, lipopolysaccharide (LPS) and poly I:C were the most potent activators of MoDCs, inducing the up-regulation of co-stimulatory molecules CD80/86 and the chemokine receptor CCR7, and production of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)alpha.	Poly I-C	58-66	tumor necrosis factor	Homo sapiens	296-305
20483755-4	2010	Fibroblast-like synoviocytes were stimulated with polyinosinic-polycytidylic acid (poly [I-C]) after transfection with IRF3 or IRF7 small interfering RNA to knockdown transcription factor expression.	Poly I-C	50-81	interferon regulatory factor 3	Homo sapiens	119-123
20483755-4	2010	Fibroblast-like synoviocytes were stimulated with polyinosinic-polycytidylic acid (poly [I-C]) after transfection with IRF3 or IRF7 small interfering RNA to knockdown transcription factor expression.	Poly I-C	50-81	interferon regulatory factor 7	Homo sapiens	127-131
20483755-4	2010	Fibroblast-like synoviocytes were stimulated with polyinosinic-polycytidylic acid (poly [I-C]) after transfection with IRF3 or IRF7 small interfering RNA to knockdown transcription factor expression.	Poly I-C	83-92	interferon regulatory factor 7	Homo sapiens	127-131
20483755-5	2010	Western blots, luciferase assay after transfection with reporter constructs, quantitative PCR, and AP-1 DNA binding ELISA were performed to evaluate the role of IRF3 and IRF7 in poly (I-C)-induced signaling and synoviocyte gene expression.	Poly I-C	178-188	interferon regulatory factor 3	Homo sapiens	161-165
20483755-5	2010	Western blots, luciferase assay after transfection with reporter constructs, quantitative PCR, and AP-1 DNA binding ELISA were performed to evaluate the role of IRF3 and IRF7 in poly (I-C)-induced signaling and synoviocyte gene expression.	Poly I-C	178-188	interferon regulatory factor 7	Homo sapiens	170-174
20576118-0	2010	Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells.	Poly I-C	0-8	alkaline phosphatase, intestinal	Homo sapiens	42-45
20576118-4	2010	METHODS: This observation prompted us to investigate the contribution of the IAP family in cell response to poly(I:C) in a variety of human malignant cell types.	Poly I-C	108-116	alkaline phosphatase, intestinal	Homo sapiens	77-80
20576118-5	2010	RESULTS: We report a rapid, intense and selective increase in c-IAP2 protein expression observed under stimulation by poly(I:C)(500 ng/ml) in all types of human malignant cells.	Poly I-C	118-127	baculoviral IAP repeat containing 3	Homo sapiens	62-68
20576118-7	2010	When poly(I:C) is combined to the IAP inhibitor RMT 5265, a cooperative effect in apoptosis induction and/or inhibition of clonogenic growth is obtained in a large fraction of carcinoma and melanoma cell lines.	Poly I-C	5-13	alkaline phosphatase, intestinal	Homo sapiens	34-37
20363878-5	2010	Sertoli cells from TAM triple mutant (TAM(-/-)) mice exhibit an excessive activation of TLR3 in response to its ligand polyinosinic-polycytidylic acid, resulting in the up-regulation of inflammatory cytokines including IL-1beta, IL-6, TNFalpha, and type I interferons (alpha and beta).	Poly I-C	119-150	toll-like receptor 3	Mus musculus	88-92
20080226-1	2010	OBJECTIVE: The purpose of this study was to explore the potential of toll-like receptor-3 stimulation, with polyI:C(12)U (poly[l].poly[C(12),U]; rintatolimod [Ampligen; Hemispherx Biopharma, Philadelphia, PA]) to enhance bioactivity of cancer immunotherapies.	Poly I-C	108-115	toll-like receptor 3	Mus musculus	69-89
20019748-2	2010	We show here that HaCaT human keratinocytes are susceptible to apoptosis induction by the TLR3 ligand poly I:C, and use these cells as a model to analyse the apoptotic signalling pathway.	Poly I-C	102-110	toll like receptor 3	Homo sapiens	90-94
20019748-4	2010	Instead, poly I:C-induced activation of caspase-8 via TLR3 and its adapter TRIF was required for apoptosis.	Poly I-C	9-17	caspase 8	Homo sapiens	40-49
20019748-4	2010	Instead, poly I:C-induced activation of caspase-8 via TLR3 and its adapter TRIF was required for apoptosis.	Poly I-C	9-17	toll like receptor 3	Homo sapiens	54-58
20019748-4	2010	Instead, poly I:C-induced activation of caspase-8 via TLR3 and its adapter TRIF was required for apoptosis.	Poly I-C	9-17	TIR domain containing adaptor molecule 1	Homo sapiens	75-79
20019748-6	2010	Significantly, sensitisation towards poly I:C-dependent caspase-8 activation and apoptosis in melanoma cells was also achieved by the synthetic Smac mimetic/inhibitor of apoptosis protein (IAP) antagonist, LBW242, or by specific downregulation of cIAP1 by siRNA.	Poly I-C	37-45	caspase 8	Homo sapiens	56-65
20019748-6	2010	Significantly, sensitisation towards poly I:C-dependent caspase-8 activation and apoptosis in melanoma cells was also achieved by the synthetic Smac mimetic/inhibitor of apoptosis protein (IAP) antagonist, LBW242, or by specific downregulation of cIAP1 by siRNA.	Poly I-C	37-45	magnesium transporter 1	Homo sapiens	189-192
20019748-6	2010	Significantly, sensitisation towards poly I:C-dependent caspase-8 activation and apoptosis in melanoma cells was also achieved by the synthetic Smac mimetic/inhibitor of apoptosis protein (IAP) antagonist, LBW242, or by specific downregulation of cIAP1 by siRNA.	Poly I-C	37-45	baculoviral IAP repeat containing 2	Homo sapiens	247-252
20479117-6	2010	DNGR-1+ BDCA3hi DCs respond to poly I:C and agonists of TLR8, but not of TLR7, and produce interleukin (IL)-12 when given innate and T cell-derived signals.	Poly I-C	31-39	C-type lectin domain containing 9A	Homo sapiens	0-6
20479117-6	2010	DNGR-1+ BDCA3hi DCs respond to poly I:C and agonists of TLR8, but not of TLR7, and produce interleukin (IL)-12 when given innate and T cell-derived signals.	Poly I-C	31-39	thrombomodulin	Homo sapiens	8-13
20607500-7	2010	Auranofin inhibited nuclear factor-kappaB and interferon (IFN) regulatory factor 3 (IRF3) activation induced by polyinosinic-polycytidylic acid (poly[I:C]).	Poly I-C	112-143	interferon alpha 1	Homo sapiens	58-61
20607500-7	2010	Auranofin inhibited nuclear factor-kappaB and interferon (IFN) regulatory factor 3 (IRF3) activation induced by polyinosinic-polycytidylic acid (poly[I:C]).	Poly I-C	112-143	interferon regulatory factor 3	Homo sapiens	84-88
20607500-8	2010	Auranofin inhibited poly[I:C]-induced phosphorylation of IRF3 as well as IFN-inducible genes such as IFN inducible protein-10.	Poly I-C	20-28	interferon regulatory factor 3	Homo sapiens	57-61
20574121-7	2010	RESULTS: Flow cytometry results demonstrated a comparable high level of CD83 expression on the mature dendritic cells generated by TNF-alpha, CpG, Poly I:C, and LPS treatment of the immature dendritic cells.	Poly I-C	147-155	CD83 molecule	Homo sapiens	72-76
19007989-3	2010	Results showed that poly IC stimulation down-regulated the expressions of TLR7 and TLR8 in alveolar macrophages (AMs) and imDCs.	Poly I-C	20-27	toll like receptor 7	Homo sapiens	74-78
20107175-8	2010	The maturation of immature DCs was observed with the use of TSLP containing conditioned media from corneal epithelial cultures exposed to polyI:C, which stimulates TSLP production.	Poly I-C	138-145	thymic stromal lymphopoietin	Mus musculus	60-64
20107175-8	2010	The maturation of immature DCs was observed with the use of TSLP containing conditioned media from corneal epithelial cultures exposed to polyI:C, which stimulates TSLP production.	Poly I-C	138-145	thymic stromal lymphopoietin	Mus musculus	164-168
19007989-3	2010	Results showed that poly IC stimulation down-regulated the expressions of TLR7 and TLR8 in alveolar macrophages (AMs) and imDCs.	Poly I-C	20-27	toll like receptor 8	Homo sapiens	83-87
20089415-0	2010	Poly(I:C) induces BLyS-expression of airway fibroblasts through phosphatidylinositol 3-kinase.	Poly I-C	0-8	TNF superfamily member 13b	Homo sapiens	18-22
20089415-3	2010	The expression of BLyS by nasal fibroblasts in the presence of polyinocinic-polycytidykic acid (poly(I:C)) was markedly induced, to a level of more than 100 times higher than that observed in the absence of poly(I:C).	Poly I-C	96-105	TNF superfamily member 13b	Homo sapiens	18-22
20089415-3	2010	The expression of BLyS by nasal fibroblasts in the presence of polyinocinic-polycytidykic acid (poly(I:C)) was markedly induced, to a level of more than 100 times higher than that observed in the absence of poly(I:C).	Poly I-C	96-104	TNF superfamily member 13b	Homo sapiens	18-22
20356041-5	2010	ILG inhibited interferon regulatory factor 3 activation induced by LPS or polyinosinic-polycytidylic acid, as well as interferon-inducible genes, such as interferon-inducible protein-10.	Poly I-C	74-105	interferon regulatory factor 3	Homo sapiens	14-44
20089415-5	2010	Pre-incubation with the PI3-kinase inhibitor LY294002 or Wortmanin reversed the poly(I:C)-induced production and expression of BLyS.	Poly I-C	80-89	peptidase inhibitor 3	Homo sapiens	24-27
20089415-5	2010	Pre-incubation with the PI3-kinase inhibitor LY294002 or Wortmanin reversed the poly(I:C)-induced production and expression of BLyS.	Poly I-C	80-89	TNF superfamily member 13b	Homo sapiens	127-131
20089415-7	2010	Thus, we were able to show that PI3-kinase signaling is directly involved in poly(I:C)-induced BLyS-expression in nasal airway fibroblasts.	Poly I-C	77-86	peptidase inhibitor 3	Homo sapiens	32-35
20089415-7	2010	Thus, we were able to show that PI3-kinase signaling is directly involved in poly(I:C)-induced BLyS-expression in nasal airway fibroblasts.	Poly I-C	77-86	TNF superfamily member 13b	Homo sapiens	95-99
20333625-8	2010	Notably, distinct adjuvants allowed qualitative modulation of CD4+ T-cell behavior: poly I:C induced a strong IL-12-independent Th1 response, whereas curdlan led to the priming of Th17 cells.	Poly I-C	84-92	CD4 molecule	Homo sapiens	62-65
20218969-3	2010	Results showed that exogenously added apoE suppressed the LPS and poly(I-C) induction of IL (interleukin)-6, IL-1beta and TNF-alpha (tumour necrosis factor-alpha) secretion by RAW 264.7 cells.	Poly I-C	66-75	apolipoprotein E	Mus musculus	38-42
20218969-3	2010	Results showed that exogenously added apoE suppressed the LPS and poly(I-C) induction of IL (interleukin)-6, IL-1beta and TNF-alpha (tumour necrosis factor-alpha) secretion by RAW 264.7 cells.	Poly I-C	66-75	interleukin 6	Mus musculus	89-107
20218969-3	2010	Results showed that exogenously added apoE suppressed the LPS and poly(I-C) induction of IL (interleukin)-6, IL-1beta and TNF-alpha (tumour necrosis factor-alpha) secretion by RAW 264.7 cells.	Poly I-C	66-75	interleukin 1 beta	Mus musculus	109-117
20218969-3	2010	Results showed that exogenously added apoE suppressed the LPS and poly(I-C) induction of IL (interleukin)-6, IL-1beta and TNF-alpha (tumour necrosis factor-alpha) secretion by RAW 264.7 cells.	Poly I-C	66-75	tumor necrosis factor	Mus musculus	122-131
20218969-6	2010	Reductive methylation of lysine residues in apoE, which abolished its receptor-binding capability without affecting its ability to interact with HSPGs (heparin sulfate proteoglycans), inhibited the ability of apoE to suppress macrophage responses to LPS, but had no effect on apoE suppression of poly(I-C)-induced macrophage activation.	Poly I-C	296-305	apolipoprotein E	Mus musculus	44-48
20218969-6	2010	Reductive methylation of lysine residues in apoE, which abolished its receptor-binding capability without affecting its ability to interact with HSPGs (heparin sulfate proteoglycans), inhibited the ability of apoE to suppress macrophage responses to LPS, but had no effect on apoE suppression of poly(I-C)-induced macrophage activation.	Poly I-C	296-305	apolipoprotein E	Mus musculus	209-213
20218969-6	2010	Reductive methylation of lysine residues in apoE, which abolished its receptor-binding capability without affecting its ability to interact with HSPGs (heparin sulfate proteoglycans), inhibited the ability of apoE to suppress macrophage responses to LPS, but had no effect on apoE suppression of poly(I-C)-induced macrophage activation.	Poly I-C	296-305	apolipoprotein E	Mus musculus	209-213
20218969-7	2010	The ability of apoE to suppress poly(I-C)-induced pro-inflammatory cytokine production was abolished by heparinase treatment of RAW 264.7 cells to remove cell-surface HSPGs.	Poly I-C	32-41	apolipoprotein E	Mus musculus	15-19
20051250-5	2010	In contrast, poly(I:C) (TLR3 agonist) and LPS (TLR4 agonist) did not induce any of these responses.	Poly I-C	13-22	toll-like receptor 3	Ovis aries	24-28
20233880-4	2010	Activation of TLR3 by polyinosinic-polycytidylic acid (polyI:C) leads to induction of multiple inflammatory pathways, including NF-kappaB, mitogen-activated protein kinases, and interferon (IFN) regulatory factors.	Poly I-C	22-53	toll-like receptor 3	Mus musculus	14-18
20200155-8	2010	Finally, we demonstrated that TRIS was associated with TRIF upon TLR3 activation by poly(I-C).	Poly I-C	84-93	TIR domain containing adaptor molecule 1	Homo sapiens	55-59
20200155-8	2010	Finally, we demonstrated that TRIS was associated with TRIF upon TLR3 activation by poly(I-C).	Poly I-C	84-93	toll like receptor 3	Homo sapiens	65-69
20233880-4	2010	Activation of TLR3 by polyinosinic-polycytidylic acid (polyI:C) leads to induction of multiple inflammatory pathways, including NF-kappaB, mitogen-activated protein kinases, and interferon (IFN) regulatory factors.	Poly I-C	55-62	toll-like receptor 3	Mus musculus	14-18
20233880-5	2010	We explored the potential of TLR3 stimulation in prostate cancer immunotherapy and showed that treatment with polyI:C can strongly suppress both s.c. implanted TRAMP tumors in syngenic mice as well as orthotopic prostate cancers in TRAMP C57Bl6 x FvB F1 Tg(+/-) transgenic mice.	Poly I-C	110-117	toll-like receptor 3	Mus musculus	29-33
20233880-5	2010	We explored the potential of TLR3 stimulation in prostate cancer immunotherapy and showed that treatment with polyI:C can strongly suppress both s.c. implanted TRAMP tumors in syngenic mice as well as orthotopic prostate cancers in TRAMP C57Bl6 x FvB F1 Tg(+/-) transgenic mice.	Poly I-C	110-117	tumor necrosis factor receptor superfamily, member 25	Mus musculus	160-165
20233880-5	2010	We explored the potential of TLR3 stimulation in prostate cancer immunotherapy and showed that treatment with polyI:C can strongly suppress both s.c. implanted TRAMP tumors in syngenic mice as well as orthotopic prostate cancers in TRAMP C57Bl6 x FvB F1 Tg(+/-) transgenic mice.	Poly I-C	110-117	tumor necrosis factor receptor superfamily, member 25	Mus musculus	232-237
20233880-7	2010	Like TLR3(-/-) mice, IFN-alpha receptor 1 (IFNAR1)(-/-) mice exhibited reduced tumor surveillance and impaired tumor suppression following polyI:C treatment.	Poly I-C	139-146	interferon (alpha and beta) receptor 1	Mus musculus	21-41
20233880-7	2010	Like TLR3(-/-) mice, IFN-alpha receptor 1 (IFNAR1)(-/-) mice exhibited reduced tumor surveillance and impaired tumor suppression following polyI:C treatment.	Poly I-C	139-146	interferon (alpha and beta) receptor 1	Mus musculus	43-49
20079850-6	2010	The expression of IRF1 after challenged with LPS and poly I:C was tested in blood, spleen and liver, which showed that IRF1 changed obviously with the most significantly up-regulated expression was 37 times (at 6 h) after injection with poly I:C in the blood and 13 times (at 3 h) after injection with LPS in the liver compared with the control values (p < 0.01).	Poly I-C	53-61	interferon regulatory factor 1	Larimichthys crocea	18-22
20079850-6	2010	The expression of IRF1 after challenged with LPS and poly I:C was tested in blood, spleen and liver, which showed that IRF1 changed obviously with the most significantly up-regulated expression was 37 times (at 6 h) after injection with poly I:C in the blood and 13 times (at 3 h) after injection with LPS in the liver compared with the control values (p < 0.01).	Poly I-C	53-61	interferon regulatory factor 1	Larimichthys crocea	119-123
20079850-6	2010	The expression of IRF1 after challenged with LPS and poly I:C was tested in blood, spleen and liver, which showed that IRF1 changed obviously with the most significantly up-regulated expression was 37 times (at 6 h) after injection with poly I:C in the blood and 13 times (at 3 h) after injection with LPS in the liver compared with the control values (p < 0.01).	Poly I-C	237-245	interferon regulatory factor 1	Larimichthys crocea	18-22
20079850-6	2010	The expression of IRF1 after challenged with LPS and poly I:C was tested in blood, spleen and liver, which showed that IRF1 changed obviously with the most significantly up-regulated expression was 37 times (at 6 h) after injection with poly I:C in the blood and 13 times (at 3 h) after injection with LPS in the liver compared with the control values (p < 0.01).	Poly I-C	237-245	interferon regulatory factor 1	Larimichthys crocea	119-123
20164430-2	2010	Poly I:C is sensed by both TLR3 in the endosomes and melanoma differentiation-associated protein 5 (MDA5) in the cytoplasm.	Poly I-C	0-8	toll-like receptor 3	Mus musculus	27-31
20123717-12	2010	Mechanistically, poly(I:C) given to human monocyte-derived macrophages before or after Schu 4 or LVS challenge (multiplicity of infection, 20:1) had significantly reduced intracellular bacterial replication (P < 0.05).	Poly I-C	17-26	lacking vigorous sperm	Mus musculus	97-100
20193035-8	2010	BCL10 gene displays the opposite expression trend between the two treatments mimic virus and bacteria of polyriboinosinic-polyribocytidylic acid (Poly I:C) and lipopolysaccharide (LPS).	Poly I-C	105-144	BCL10	Sus scrofa	0-5
20193035-8	2010	BCL10 gene displays the opposite expression trend between the two treatments mimic virus and bacteria of polyriboinosinic-polyribocytidylic acid (Poly I:C) and lipopolysaccharide (LPS).	Poly I-C	146-154	BCL10	Sus scrofa	0-5
20164430-2	2010	Poly I:C is sensed by both TLR3 in the endosomes and melanoma differentiation-associated protein 5 (MDA5) in the cytoplasm.	Poly I-C	0-8	interferon induced with helicase C domain 1	Mus musculus	53-98
20164430-2	2010	Poly I:C is sensed by both TLR3 in the endosomes and melanoma differentiation-associated protein 5 (MDA5) in the cytoplasm.	Poly I-C	0-8	interferon induced with helicase C domain 1	Mus musculus	100-104
20164430-6	2010	We conclude that MDA5 and TLR3 mediate substantially distinct yet complementary functions during poly I:C-mediated activation of Ag-specific CD8 T cell responses.	Poly I-C	97-105	interferon induced with helicase C domain 1	Mus musculus	17-21
20164430-6	2010	We conclude that MDA5 and TLR3 mediate substantially distinct yet complementary functions during poly I:C-mediated activation of Ag-specific CD8 T cell responses.	Poly I-C	97-105	toll-like receptor 3	Mus musculus	26-30
20231782-12	2010	Significantly high levels of mouse IP-10 in BALB/c mice was also detected when SARS-CoV-infected mice were treated with the interferon inducer, polyriboinosinic-polyribocytidylic acid stabilized with poly-L-lysine and carboxymethyl cellulose (poly IC:LC).	Poly I-C	144-183	chemokine (C-X-C motif) ligand 10	Mus musculus	35-40
20006962-6	2010	Additional experiments utilizing CpG and Poly I:C stimulation to selectively activate the MyD88-dependent and -independent pathways via TLR9 and TLR3 substantiated the finding that malyngamide F acetate selectively inhibits the MyD88-dependent pathway.	Poly I-C	41-49	myeloid differentiation primary response gene 88	Mus musculus	90-95
20006962-6	2010	Additional experiments utilizing CpG and Poly I:C stimulation to selectively activate the MyD88-dependent and -independent pathways via TLR9 and TLR3 substantiated the finding that malyngamide F acetate selectively inhibits the MyD88-dependent pathway.	Poly I-C	41-49	toll-like receptor 9	Mus musculus	136-140
20006962-6	2010	Additional experiments utilizing CpG and Poly I:C stimulation to selectively activate the MyD88-dependent and -independent pathways via TLR9 and TLR3 substantiated the finding that malyngamide F acetate selectively inhibits the MyD88-dependent pathway.	Poly I-C	41-49	toll-like receptor 3	Mus musculus	145-149
20034529-8	2010	In this setting, poly(I:C) further augments IL-6, IL-12p35, IL-23p19, and IL-27p28 transcription, whereas lipopolysaccharide (LPS) increases IL-23p19 and IL-27p28 transcription.	Poly I-C	17-26	interleukin 6	Homo sapiens	44-48
20034529-8	2010	In this setting, poly(I:C) further augments IL-6, IL-12p35, IL-23p19, and IL-27p28 transcription, whereas lipopolysaccharide (LPS) increases IL-23p19 and IL-27p28 transcription.	Poly I-C	17-26	interleukin 23 subunit alpha	Homo sapiens	60-68
20034529-8	2010	In this setting, poly(I:C) further augments IL-6, IL-12p35, IL-23p19, and IL-27p28 transcription, whereas lipopolysaccharide (LPS) increases IL-23p19 and IL-27p28 transcription.	Poly I-C	17-26	interleukin 27	Homo sapiens	74-82
20026056-4	2010	PolyI:C did not expand Treg directly, but promoted the expansion of naturally occurring Treg indirectly through IL-6 produced from dendritic cells (DCs).	Poly I-C	0-7	interleukin 6	Homo sapiens	112-116
20087927-7	2010	The results of the current study suggest that one of the mechanisms by which zymosan enhances the adjuvant activity of poly(I:C) is through increased cytokine production by DCs involving the synergistic activation of poly(I:C)-induced TLR3- and zymosan-induced TLR2-mediated signaling pathways.	Poly I-C	119-128	toll-like receptor 3	Mus musculus	235-239
20087927-7	2010	The results of the current study suggest that one of the mechanisms by which zymosan enhances the adjuvant activity of poly(I:C) is through increased cytokine production by DCs involving the synergistic activation of poly(I:C)-induced TLR3- and zymosan-induced TLR2-mediated signaling pathways.	Poly I-C	119-128	toll-like receptor 2	Mus musculus	261-265
20087927-7	2010	The results of the current study suggest that one of the mechanisms by which zymosan enhances the adjuvant activity of poly(I:C) is through increased cytokine production by DCs involving the synergistic activation of poly(I:C)-induced TLR3- and zymosan-induced TLR2-mediated signaling pathways.	Poly I-C	217-226	toll-like receptor 3	Mus musculus	235-239
20087927-7	2010	The results of the current study suggest that one of the mechanisms by which zymosan enhances the adjuvant activity of poly(I:C) is through increased cytokine production by DCs involving the synergistic activation of poly(I:C)-induced TLR3- and zymosan-induced TLR2-mediated signaling pathways.	Poly I-C	217-226	toll-like receptor 2	Mus musculus	261-265
19828129-5	2010	In this study, we show that human ocular surface epithelial cells, both corneal and conjuctival epithelial cells, respond to viral double-stranded RNA mimic polyI:C to produce pro-inflammatory cytokines through TLR3, while they fail to respond functionally to lipopolysaccharide, a TLR4 ligand.	Poly I-C	157-164	toll like receptor 3	Homo sapiens	211-215
19828129-5	2010	In this study, we show that human ocular surface epithelial cells, both corneal and conjuctival epithelial cells, respond to viral double-stranded RNA mimic polyI:C to produce pro-inflammatory cytokines through TLR3, while they fail to respond functionally to lipopolysaccharide, a TLR4 ligand.	Poly I-C	157-164	toll like receptor 4	Homo sapiens	282-286
19825389-13	2010	Rainbow trout anterior kidney leukocytes produced elevated levels of pro-inflammatory and type I interferon cytokines mRNA in response to stimulation with the human TLR7/8 agonist R848 or the TLR3 agonist poly I:C.	Poly I-C	205-213	toll like receptor 3	Homo sapiens	192-196
19825389-14	2010	Only poly I:C-induced IFN2 transcription was significantly suppressed in the presence of chloroquine, a compound known to block endosomal acidification and inhibit endosomal maturation.	Poly I-C	5-13	type I interferon 2	Oncorhynchus mykiss	22-26
20026056-5	2010	In addition, the expansion of Treg by IL-6 was inhibited by IFN-alpha from polyI:C-stimulated DCs.	Poly I-C	75-82	interleukin 6	Homo sapiens	38-42
20026056-5	2010	In addition, the expansion of Treg by IL-6 was inhibited by IFN-alpha from polyI:C-stimulated DCs.	Poly I-C	75-82	interferon alpha 1	Homo sapiens	60-69
19716847-6	2010	We demonstrated that neonatal polyI:C treatment in DN-DISC1 mice resulted in the deficits of short-term, object recognition, and hippocampus-dependent fear memories after puberty, although polyI:C treatment by itself had smaller influences on wild-type mice.	Poly I-C	30-37	disrupted in schizophrenia 1	Mus musculus	54-59
19716847-7	2010	Furthermore, polyI:C-treated DN-DISC1 mice exhibited signs of impairment of social recognition and interaction, and augmented susceptibility to MK-801-induced hyperactivity as compared with vehicle-treated wild-type mice.	Poly I-C	13-20	disrupted in schizophrenia 1	Mus musculus	32-37
20329551-7	2010	The level of TLR3 mRNA was significantly up-regulated in PolyI:C+hMPV group at the 24 hour after intranasal inoculation.	Poly I-C	57-64	toll-like receptor 3	Mus musculus	13-17
20329551-9	2010	PolyI:C was capable of inhibiting viral replication in the lung of mice and reducing lung inflammation probably through the early activation of TLR3.	Poly I-C	0-7	toll-like receptor 3	Mus musculus	144-148
20427039-2	2010	Our data show for the first time that NK cells produce high levels of cytokines interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in response to stimulation with the artificial RNA analogue Poly I:C without additional cytokines or contact to other types of immune cells.	Poly I-C	235-243	interleukin 6	Homo sapiens	169-173
20615213-9	2010	The IL-32alpha isoform was expressed intracellularly in response to TNF-alpha and poly I:C and not released in culture supernatants.	Poly I-C	82-90	interleukin 32	Homo sapiens	4-14
19830728-2	2010	When investigating the pathways regulating B7-H1 expression in monocyte-derived DC (MoDC), freshly isolated myeloid DC (mDC) and plasmacytoid DC, respectively, we showed that in MoDC and mDC B7-H1 expression was upregulated by a standard cytokine cocktail, poly I:C or LPS.	Poly I-C	257-265	chemokine (C-C motif) ligand 22	Mus musculus	187-190
19830728-3	2010	MoDC utilize ERK and PI3K pathways to upregulate B7-H1 in response to cytokines, whereas p38 kinase was predominantly utilized in response to poly I:C. In mDC, ERK and p38 pathways are involved in B7-H1 regulation, and similar to MoDC, mainly p38 signaling was required for poly I:C-induced expression of B7-H1.	Poly I-C	142-150	mitogen-activated protein kinase 14	Homo sapiens	89-92
19830728-3	2010	MoDC utilize ERK and PI3K pathways to upregulate B7-H1 in response to cytokines, whereas p38 kinase was predominantly utilized in response to poly I:C. In mDC, ERK and p38 pathways are involved in B7-H1 regulation, and similar to MoDC, mainly p38 signaling was required for poly I:C-induced expression of B7-H1.	Poly I-C	142-150	chemokine (C-C motif) ligand 22	Mus musculus	155-158
19830728-3	2010	MoDC utilize ERK and PI3K pathways to upregulate B7-H1 in response to cytokines, whereas p38 kinase was predominantly utilized in response to poly I:C. In mDC, ERK and p38 pathways are involved in B7-H1 regulation, and similar to MoDC, mainly p38 signaling was required for poly I:C-induced expression of B7-H1.	Poly I-C	142-150	mitogen-activated protein kinase 1	Homo sapiens	160-163
19830728-3	2010	MoDC utilize ERK and PI3K pathways to upregulate B7-H1 in response to cytokines, whereas p38 kinase was predominantly utilized in response to poly I:C. In mDC, ERK and p38 pathways are involved in B7-H1 regulation, and similar to MoDC, mainly p38 signaling was required for poly I:C-induced expression of B7-H1.	Poly I-C	142-150	mitogen-activated protein kinase 14	Homo sapiens	168-171
19830728-3	2010	MoDC utilize ERK and PI3K pathways to upregulate B7-H1 in response to cytokines, whereas p38 kinase was predominantly utilized in response to poly I:C. In mDC, ERK and p38 pathways are involved in B7-H1 regulation, and similar to MoDC, mainly p38 signaling was required for poly I:C-induced expression of B7-H1.	Poly I-C	142-150	mitogen-activated protein kinase 14	Homo sapiens	168-171
19741251-10	2010	Real-time PCR analysis showed that poly I:C induced TSLP mRNA expression in HCJEs in an endosomal-function-dependent manner and that rTSLP could induce IL-13 mRNA expression in the mast cells synergistically with IL-33.	Poly I-C	35-43	thymic stromal lymphopoietin	Homo sapiens	52-56
19961539-7	2010	Immunostimulation of zebrafish head kidney and spleen cells with phytohaemagglutinin, lipopolysaccharide or Poly I:C, showed a correlation between the expression of t-bet, stat6 and foxp3 with other genes involved in Th and T(reg) responses using quantitative PCR.	Poly I-C	108-116	T-box transcription factor 21	Danio rerio	165-170
19961539-7	2010	Immunostimulation of zebrafish head kidney and spleen cells with phytohaemagglutinin, lipopolysaccharide or Poly I:C, showed a correlation between the expression of t-bet, stat6 and foxp3 with other genes involved in Th and T(reg) responses using quantitative PCR.	Poly I-C	108-116	signal transducer and activator of transcription 6, interleukin-4 induced	Danio rerio	172-177
19961539-7	2010	Immunostimulation of zebrafish head kidney and spleen cells with phytohaemagglutinin, lipopolysaccharide or Poly I:C, showed a correlation between the expression of t-bet, stat6 and foxp3 with other genes involved in Th and T(reg) responses using quantitative PCR.	Poly I-C	108-116	forkhead box P3a	Danio rerio	182-187
19799901-10	2010	Interestingly, PGLYRP-2 was strongest stimulated by polyI:C representing viral dsRNA.	Poly I-C	52-59	peptidoglycan recognition protein 2	Homo sapiens	15-23
19799901-11	2010	TLR3 antibody or NFkB inhibitor blocked IRF3 and NFkB p65 activation as well as polyI:C-stimulated PGLYRP-2.	Poly I-C	80-87	toll like receptor 3	Homo sapiens	0-4
19799901-11	2010	TLR3 antibody or NFkB inhibitor blocked IRF3 and NFkB p65 activation as well as polyI:C-stimulated PGLYRP-2.	Poly I-C	80-87	peptidoglycan recognition protein 2	Homo sapiens	99-107
19752565-6	2010	Polyinosinic:polycytidylic acid [poly(I:C)], an agonist for TLR3, was used to assess its functional role in purified eosinophils and the intracellular signaling pathways involved.	Poly I-C	0-31	toll like receptor 3	Homo sapiens	60-64
19752565-6	2010	Polyinosinic:polycytidylic acid [poly(I:C)], an agonist for TLR3, was used to assess its functional role in purified eosinophils and the intracellular signaling pathways involved.	Poly I-C	33-42	toll like receptor 3	Homo sapiens	60-64
19752565-10	2010	Stimulation with poly(I:C) increased the percentage of CD11b+ cells and enhanced the secretion of IL-8, effects mediated via the p38 mitogen-activated protein kinases and nuclear factor-kappaB signaling pathways.	Poly I-C	17-26	integrin subunit alpha M	Homo sapiens	55-60
19752565-10	2010	Stimulation with poly(I:C) increased the percentage of CD11b+ cells and enhanced the secretion of IL-8, effects mediated via the p38 mitogen-activated protein kinases and nuclear factor-kappaB signaling pathways.	Poly I-C	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
19752565-10	2010	Stimulation with poly(I:C) increased the percentage of CD11b+ cells and enhanced the secretion of IL-8, effects mediated via the p38 mitogen-activated protein kinases and nuclear factor-kappaB signaling pathways.	Poly I-C	17-26	mitogen-activated protein kinase 14	Homo sapiens	129-132
19752565-11	2010	Moreover, pretreatment with IL-5 augmented the poly(I:C)-induced IL-8 release.	Poly I-C	47-56	interleukin 5	Homo sapiens	28-32
19752565-11	2010	Moreover, pretreatment with IL-5 augmented the poly(I:C)-induced IL-8 release.	Poly I-C	47-56	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
19995959-9	2009	These results demonstrate distinct yet complementary roles for MDA5 and TLR3 in poly(I:C)-mediated NK cell activation.	Poly I-C	80-89	interferon induced with helicase C domain 1	Mus musculus	63-67
19995959-9	2009	These results demonstrate distinct yet complementary roles for MDA5 and TLR3 in poly(I:C)-mediated NK cell activation.	Poly I-C	80-89	toll-like receptor 3	Mus musculus	72-76
19418018-0	2009	Resistance to activation-induced cell death and elevated FLIPL expression of CD4+ T cells in a polyI:C-induced primary biliary cirrhosis mouse model.	Poly I-C	95-102	CD4 antigen	Mus musculus	77-80
19776675-4	2009	The modulating effect of polyinosinic-polycytidylic acid (poly I:C) on expression of B7-H2, CD40 and OX40L was also examined.	Poly I-C	25-56	inducible T cell costimulator ligand	Homo sapiens	85-90
19776675-4	2009	The modulating effect of polyinosinic-polycytidylic acid (poly I:C) on expression of B7-H2, CD40 and OX40L was also examined.	Poly I-C	25-56	CD40 molecule	Homo sapiens	92-96
19776675-4	2009	The modulating effect of polyinosinic-polycytidylic acid (poly I:C) on expression of B7-H2, CD40 and OX40L was also examined.	Poly I-C	25-56	TNF superfamily member 4	Homo sapiens	101-106
19776675-4	2009	The modulating effect of polyinosinic-polycytidylic acid (poly I:C) on expression of B7-H2, CD40 and OX40L was also examined.	Poly I-C	58-66	inducible T cell costimulator ligand	Homo sapiens	85-90
19776675-4	2009	The modulating effect of polyinosinic-polycytidylic acid (poly I:C) on expression of B7-H2, CD40 and OX40L was also examined.	Poly I-C	58-66	CD40 molecule	Homo sapiens	92-96
19776675-4	2009	The modulating effect of polyinosinic-polycytidylic acid (poly I:C) on expression of B7-H2, CD40 and OX40L was also examined.	Poly I-C	58-66	TNF superfamily member 4	Homo sapiens	101-106
19776675-7	2009	ASM cells responded to poly I:C with upregulated expression of B7-H2, CD40 and OX40L and displayed enhanced adhesion of activated T cells.	Poly I-C	23-31	inducible T cell costimulator ligand	Homo sapiens	63-68
19776675-7	2009	ASM cells responded to poly I:C with upregulated expression of B7-H2, CD40 and OX40L and displayed enhanced adhesion of activated T cells.	Poly I-C	23-31	CD40 molecule	Homo sapiens	70-74
19776675-7	2009	ASM cells responded to poly I:C with upregulated expression of B7-H2, CD40 and OX40L and displayed enhanced adhesion of activated T cells.	Poly I-C	23-31	TNF superfamily member 4	Homo sapiens	79-84
19776675-11	2009	In addition, the modulation of B7-H2, CD40 and OX40L expression and function by poly I:C may have important implications for the function of virus-infected ASM cells.	Poly I-C	80-88	inducible T cell costimulator ligand	Homo sapiens	31-36
19776675-11	2009	In addition, the modulation of B7-H2, CD40 and OX40L expression and function by poly I:C may have important implications for the function of virus-infected ASM cells.	Poly I-C	80-88	CD40 molecule	Homo sapiens	38-42
19776675-11	2009	In addition, the modulation of B7-H2, CD40 and OX40L expression and function by poly I:C may have important implications for the function of virus-infected ASM cells.	Poly I-C	80-88	TNF superfamily member 4	Homo sapiens	47-52
19779021-5	2009	Using the cytokine IL-8 as a physiological read out of the inflammatory response, we found that TLR3 is the most functional of the expressed TLRs in both primary and immortalized esophageal epithelial cell lines in response to its synthetic ligand polyinosinic polycytidylic acid [poly(I:C)].	Poly I-C	248-279	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
19779021-5	2009	Using the cytokine IL-8 as a physiological read out of the inflammatory response, we found that TLR3 is the most functional of the expressed TLRs in both primary and immortalized esophageal epithelial cell lines in response to its synthetic ligand polyinosinic polycytidylic acid [poly(I:C)].	Poly I-C	248-279	toll like receptor 3	Homo sapiens	96-100
19779021-6	2009	Through reporter gene studies, we show that poly(I:C)-induced NF-kappaB activation is critical for the transactivation of the IL-8 promoter in vitro and that nuclear translocation of NF-kappaB occurs at an early time point following poly(I:C) stimulation of esophageal epithelial cells.	Poly I-C	44-53	nuclear factor kappa B subunit 1	Homo sapiens	62-71
19779021-6	2009	Through reporter gene studies, we show that poly(I:C)-induced NF-kappaB activation is critical for the transactivation of the IL-8 promoter in vitro and that nuclear translocation of NF-kappaB occurs at an early time point following poly(I:C) stimulation of esophageal epithelial cells.	Poly I-C	44-53	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
19779021-6	2009	Through reporter gene studies, we show that poly(I:C)-induced NF-kappaB activation is critical for the transactivation of the IL-8 promoter in vitro and that nuclear translocation of NF-kappaB occurs at an early time point following poly(I:C) stimulation of esophageal epithelial cells.	Poly I-C	44-52	nuclear factor kappa B subunit 1	Homo sapiens	62-71
19779021-6	2009	Through reporter gene studies, we show that poly(I:C)-induced NF-kappaB activation is critical for the transactivation of the IL-8 promoter in vitro and that nuclear translocation of NF-kappaB occurs at an early time point following poly(I:C) stimulation of esophageal epithelial cells.	Poly I-C	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
19779021-7	2009	Importantly, we also show that poly(I:C) stimulation induces the NF-kappaB-dependent esophageal epithelial expression of TLR2, leading to enhanced epithelial responsiveness of EPC2-hTERT cells to TLR2 ligand stimulation, suggesting an important regulatory role for TLR3-mediated NF-kappaB signaling in the innate immune response of esophageal epithelial cells.	Poly I-C	31-40	nuclear factor kappa B subunit 1	Homo sapiens	65-74
19779021-7	2009	Importantly, we also show that poly(I:C) stimulation induces the NF-kappaB-dependent esophageal epithelial expression of TLR2, leading to enhanced epithelial responsiveness of EPC2-hTERT cells to TLR2 ligand stimulation, suggesting an important regulatory role for TLR3-mediated NF-kappaB signaling in the innate immune response of esophageal epithelial cells.	Poly I-C	31-40	toll like receptor 2	Homo sapiens	121-125
19779021-7	2009	Importantly, we also show that poly(I:C) stimulation induces the NF-kappaB-dependent esophageal epithelial expression of TLR2, leading to enhanced epithelial responsiveness of EPC2-hTERT cells to TLR2 ligand stimulation, suggesting an important regulatory role for TLR3-mediated NF-kappaB signaling in the innate immune response of esophageal epithelial cells.	Poly I-C	31-40	enhancer of polycomb homolog 2	Homo sapiens	176-180
19779021-7	2009	Importantly, we also show that poly(I:C) stimulation induces the NF-kappaB-dependent esophageal epithelial expression of TLR2, leading to enhanced epithelial responsiveness of EPC2-hTERT cells to TLR2 ligand stimulation, suggesting an important regulatory role for TLR3-mediated NF-kappaB signaling in the innate immune response of esophageal epithelial cells.	Poly I-C	31-40	telomerase reverse transcriptase	Homo sapiens	181-186
19779021-7	2009	Importantly, we also show that poly(I:C) stimulation induces the NF-kappaB-dependent esophageal epithelial expression of TLR2, leading to enhanced epithelial responsiveness of EPC2-hTERT cells to TLR2 ligand stimulation, suggesting an important regulatory role for TLR3-mediated NF-kappaB signaling in the innate immune response of esophageal epithelial cells.	Poly I-C	31-40	toll like receptor 2	Homo sapiens	196-200
19779021-7	2009	Importantly, we also show that poly(I:C) stimulation induces the NF-kappaB-dependent esophageal epithelial expression of TLR2, leading to enhanced epithelial responsiveness of EPC2-hTERT cells to TLR2 ligand stimulation, suggesting an important regulatory role for TLR3-mediated NF-kappaB signaling in the innate immune response of esophageal epithelial cells.	Poly I-C	31-40	toll like receptor 3	Homo sapiens	265-269
19779021-7	2009	Importantly, we also show that poly(I:C) stimulation induces the NF-kappaB-dependent esophageal epithelial expression of TLR2, leading to enhanced epithelial responsiveness of EPC2-hTERT cells to TLR2 ligand stimulation, suggesting an important regulatory role for TLR3-mediated NF-kappaB signaling in the innate immune response of esophageal epithelial cells.	Poly I-C	31-40	nuclear factor kappa B subunit 1	Homo sapiens	279-288
19779466-8	2009	Additionally, poly I:C-treated rats exhibited a significant increase in placental TLR3 expression and proinflammatory/anti-inflammatory cytokine ratio compared to vehicle-treated rats.	Poly I-C	14-22	toll-like receptor 3	Rattus norvegicus	82-86
19418018-2	2009	We established a PBC animal model by injecting C57BL/6 mice with polyI:C to study activation-induced cell death (AICD) in CD4+ T lymphocytes and changes of apoptosis-associated molecules as a first step to understand the immune tolerance of PBC mice.	Poly I-C	65-72	CD4 antigen	Mus musculus	122-125
20141043-4	2009	Priority data concerning the suppression of the activity of neutral sphingomyelinase (nSMase) - the key enzyme of the sphingomyelin cascade - in membranes ofthe cells from the brain cortex on the 3d day after Poly I : C administration to rats have been obtained.	Poly I-C	209-219	sphingomyelin phosphodiesterase 2	Rattus norvegicus	60-84
19632268-1	2009	Two new interferon stimulated gene 15 (ISG15) family members were identified in a subtractive cDNA library constructed from a mixture of head kidney and spleen of Atlantic cod (Gadus morhua) stimulated with polyinosinic:polycytidylic acid (poly I:C).	Poly I-C	240-248	ISG15 ubiquitin like modifier	Homo sapiens	39-44
20141043-4	2009	Priority data concerning the suppression of the activity of neutral sphingomyelinase (nSMase) - the key enzyme of the sphingomyelin cascade - in membranes ofthe cells from the brain cortex on the 3d day after Poly I : C administration to rats have been obtained.	Poly I-C	209-219	sphingomyelin phosphodiesterase 2	Rattus norvegicus	86-92
19581629-0	2009	Organization of hyaluronan and versican in the extracellular matrix of human fibroblasts treated with the viral mimetic poly I:C.	Poly I-C	120-128	versican	Homo sapiens	31-39
19850889-4	2009	In primary mesangial cells, poly I:C RNA-mediated IFN-beta induction was partially TRIF dependent; however, when poly I:C RNA was complexed with cationic lipids to enhance cytosolic uptake, mesangial cells produced large amounts of IFN-alpha and IFN-beta independent of TRIF.	Poly I-C	28-36	interferon beta 1, fibroblast	Mus musculus	50-58
19850889-4	2009	In primary mesangial cells, poly I:C RNA-mediated IFN-beta induction was partially TRIF dependent; however, when poly I:C RNA was complexed with cationic lipids to enhance cytosolic uptake, mesangial cells produced large amounts of IFN-alpha and IFN-beta independent of TRIF.	Poly I-C	28-36	toll-like receptor adaptor molecule 1	Mus musculus	83-87
19850889-4	2009	In primary mesangial cells, poly I:C RNA-mediated IFN-beta induction was partially TRIF dependent; however, when poly I:C RNA was complexed with cationic lipids to enhance cytosolic uptake, mesangial cells produced large amounts of IFN-alpha and IFN-beta independent of TRIF.	Poly I-C	28-36	interferon alpha	Mus musculus	232-241
19850889-4	2009	In primary mesangial cells, poly I:C RNA-mediated IFN-beta induction was partially TRIF dependent; however, when poly I:C RNA was complexed with cationic lipids to enhance cytosolic uptake, mesangial cells produced large amounts of IFN-alpha and IFN-beta independent of TRIF.	Poly I-C	28-36	interferon beta 1, fibroblast	Mus musculus	246-254
19850889-4	2009	In primary mesangial cells, poly I:C RNA-mediated IFN-beta induction was partially TRIF dependent; however, when poly I:C RNA was complexed with cationic lipids to enhance cytosolic uptake, mesangial cells produced large amounts of IFN-alpha and IFN-beta independent of TRIF.	Poly I-C	28-36	toll-like receptor adaptor molecule 1	Mus musculus	270-274
19850889-4	2009	In primary mesangial cells, poly I:C RNA-mediated IFN-beta induction was partially TRIF dependent; however, when poly I:C RNA was complexed with cationic lipids to enhance cytosolic uptake, mesangial cells produced large amounts of IFN-alpha and IFN-beta independent of TRIF.	Poly I-C	113-121	interferon beta 1, fibroblast	Mus musculus	50-58
19850889-4	2009	In primary mesangial cells, poly I:C RNA-mediated IFN-beta induction was partially TRIF dependent; however, when poly I:C RNA was complexed with cationic lipids to enhance cytosolic uptake, mesangial cells produced large amounts of IFN-alpha and IFN-beta independent of TRIF.	Poly I-C	113-121	interferon alpha	Mus musculus	232-241
19850889-4	2009	In primary mesangial cells, poly I:C RNA-mediated IFN-beta induction was partially TRIF dependent; however, when poly I:C RNA was complexed with cationic lipids to enhance cytosolic uptake, mesangial cells produced large amounts of IFN-alpha and IFN-beta independent of TRIF.	Poly I-C	113-121	interferon beta 1, fibroblast	Mus musculus	246-254
19850889-4	2009	In primary mesangial cells, poly I:C RNA-mediated IFN-beta induction was partially TRIF dependent; however, when poly I:C RNA was complexed with cationic lipids to enhance cytosolic uptake, mesangial cells produced large amounts of IFN-alpha and IFN-beta independent of TRIF.	Poly I-C	113-121	toll-like receptor adaptor molecule 1	Mus musculus	270-274
19573162-1	2009	Our previous studies have shown that Toll-like receptor (TLR) ligands, Poly I:C and lipopolysaccharide (LPS), are able to activate non-parenchymal liver cells and trigger the production of interferon (IFN) to inhibit hepatitis B virus replication in vivo and in vitro.	Poly I-C	71-79	interferon alpha 1	Homo sapiens	201-204
19573162-5	2009	Poly I:C transfection resulted in the production of IFN and a highly increased expression of antiviral genes in PWHs and slight inhibitory effect on WHV replication.	Poly I-C	0-8	interferon alpha 1	Homo sapiens	52-55
19821527-9	2009	CONCLUSION: Our findings demonstrate that CD11b negatively regulates NK cell activation and thus attenuates poly(I:C)-induced acute hepatitis.	Poly I-C	108-117	integrin subunit alpha M	Homo sapiens	42-47
19581629-9	2009	As seen by scanning electron microscopy, the membrane protrusions may participate in poly I:C-induced binding of monocytes to hyaluronan- and versican-rich matrices.	Poly I-C	85-93	versican	Homo sapiens	142-150
19581629-10	2009	These results suggest that poly I:C-induced hyaluronan- and versican-rich cable structures are not deposited during migration, and that cellular protrusions partially contribute to hyaluronan cable formation.	Poly I-C	27-35	versican	Homo sapiens	60-68
19728309-4	2009	Neutralizing anti-IFNAR1 or anti-IFN-beta Ab prevented the production of IFN-gamma induced by polyI:C plus IL-2/IL-12.	Poly I-C	94-101	interferon gamma	Homo sapiens	73-82
19809799-7	2009	ILG inhibited nuclear factor-kappaB and interferon regulatory factor 3 activation induced by lipopolysaccharide or polyinosinic-polycytidylic acid.	Poly I-C	115-146	interferon regulatory factor 3	Homo sapiens	40-70
19728309-5	2009	Similarly, IFN-gamma production induced by polyI:C plus IL-12 was reduced in NK cells isolated from IFNAR1(-/-) compared with WT mice.	Poly I-C	43-50	interferon gamma	Mus musculus	11-20
19728309-0	2009	PolyI:C plus IL-2 or IL-12 induce IFN-gamma production by human NK cells via autocrine IFN-beta.	Poly I-C	0-7	interferon gamma	Homo sapiens	34-43
19728309-5	2009	Similarly, IFN-gamma production induced by polyI:C plus IL-12 was reduced in NK cells isolated from IFNAR1(-/-) compared with WT mice.	Poly I-C	43-50	interferon (alpha and beta) receptor 1	Mus musculus	100-106
19728309-0	2009	PolyI:C plus IL-2 or IL-12 induce IFN-gamma production by human NK cells via autocrine IFN-beta.	Poly I-C	0-7	interferon beta 1	Homo sapiens	87-95
19728309-2	2009	We evaluated type I IFN production by human NK cells in response to polyI:C, a potent type I IFN-inducing TLR3 agonist.	Poly I-C	68-75	toll like receptor 3	Homo sapiens	106-110
19728309-6	2009	The ability of polyI:C plus IL-12 to induce IFN-gamma production was related to an increase of TLR3, Mda5 and IFNAR expression and by an increase of STAT1 and STAT4 phosphorylation.	Poly I-C	15-22	interferon gamma	Homo sapiens	44-53
19728309-3	2009	PolyI:C plus IL-2/IL-12 induced IFN-beta (but not IFN-alpha) mRNA expression and protein production by highly pure human NK cells and by the human NK cell line NK92.	Poly I-C	0-7	interferon beta 1	Homo sapiens	32-40
19728309-6	2009	The ability of polyI:C plus IL-12 to induce IFN-gamma production was related to an increase of TLR3, Mda5 and IFNAR expression and by an increase of STAT1 and STAT4 phosphorylation.	Poly I-C	15-22	toll like receptor 3	Homo sapiens	95-99
19728309-4	2009	Neutralizing anti-IFNAR1 or anti-IFN-beta Ab prevented the production of IFN-gamma induced by polyI:C plus IL-2/IL-12.	Poly I-C	94-101	interferon alpha and beta receptor subunit 1	Homo sapiens	18-24
19728309-6	2009	The ability of polyI:C plus IL-12 to induce IFN-gamma production was related to an increase of TLR3, Mda5 and IFNAR expression and by an increase of STAT1 and STAT4 phosphorylation.	Poly I-C	15-22	interferon induced with helicase C domain 1	Homo sapiens	101-105
19728309-4	2009	Neutralizing anti-IFNAR1 or anti-IFN-beta Ab prevented the production of IFN-gamma induced by polyI:C plus IL-2/IL-12.	Poly I-C	94-101	interferon beta 1	Homo sapiens	33-41
19728309-6	2009	The ability of polyI:C plus IL-12 to induce IFN-gamma production was related to an increase of TLR3, Mda5 and IFNAR expression and by an increase of STAT1 and STAT4 phosphorylation.	Poly I-C	15-22	interferon alpha and beta receptor subunit 1	Homo sapiens	110-115
19728309-6	2009	The ability of polyI:C plus IL-12 to induce IFN-gamma production was related to an increase of TLR3, Mda5 and IFNAR expression and by an increase of STAT1 and STAT4 phosphorylation.	Poly I-C	15-22	signal transducer and activator of transcription 1	Homo sapiens	149-154
19728309-6	2009	The ability of polyI:C plus IL-12 to induce IFN-gamma production was related to an increase of TLR3, Mda5 and IFNAR expression and by an increase of STAT1 and STAT4 phosphorylation.	Poly I-C	15-22	signal transducer and activator of transcription 4	Homo sapiens	159-164
19728309-7	2009	Collectively, these data demonstrate that NK cells, in response to polyI:C plus IL-2/IL-12, produce IFN-beta that induce, in an autocrine manner, the production of IFN-gamma and thereby highlight that NK cells may control the outcome of protective or injurious immune responses through type I IFN secretion.	Poly I-C	67-74	interferon beta 1	Homo sapiens	100-108
19728309-7	2009	Collectively, these data demonstrate that NK cells, in response to polyI:C plus IL-2/IL-12, produce IFN-beta that induce, in an autocrine manner, the production of IFN-gamma and thereby highlight that NK cells may control the outcome of protective or injurious immune responses through type I IFN secretion.	Poly I-C	67-74	interferon gamma	Homo sapiens	164-173
19443727-7	2009	PolyI:C (a TLR3 ligand) had the greatest effect in stimulating RACs to acquire antigen-presentation function, whereas BLP (a TLR2 ligand) had the lowest effect.	Poly I-C	0-7	toll-like receptor 3	Mus musculus	11-15
19443727-9	2009	IRBP-specific T cells activated by polyI:C-treated RACs expanded vigorously, produced significant amounts of IFN-gamma and IL-17, and induced experimental autoimmune uveitis when injected into naive mice.	Poly I-C	35-42	retinol binding protein 3, interstitial	Mus musculus	0-4
19443727-9	2009	IRBP-specific T cells activated by polyI:C-treated RACs expanded vigorously, produced significant amounts of IFN-gamma and IL-17, and induced experimental autoimmune uveitis when injected into naive mice.	Poly I-C	35-42	interferon gamma	Mus musculus	109-118
19443727-9	2009	IRBP-specific T cells activated by polyI:C-treated RACs expanded vigorously, produced significant amounts of IFN-gamma and IL-17, and induced experimental autoimmune uveitis when injected into naive mice.	Poly I-C	35-42	interleukin 17A	Mus musculus	123-128
19717524-6	2009	Mal deficiency boosted IL-6 induction by the TLR3 ligand polyinosinic-polycytidylic acid.	Poly I-C	57-88	interleukin 6	Mus musculus	23-27
19656876-7	2009	An interesting observation arising from these experiments is the ability of transiently expressed UK NSP1 to inhibit poly(I:C)-directed IRF3 activity in NIH 3T3 cells in the absence of detectable IRF3 degradation, an unexpected finding since UK virus infection was unable to block IFN secretion, and UK NSP1 expression did not result in suppression of IRF3-directed activation of the pathway.	Poly I-C	117-126	interferon regulatory factor 3	Mus musculus	136-140
19367472-3	2009	In this work, the expression of ISG15 in cultured FBL cells was detected after stimulated with poly I:C or LPS.	Poly I-C	95-103	ISG15 ubiquitin like modifier	Bos taurus	32-37
19367472-4	2009	Real-time PCR analyses revealed that the transcript of ISG15 can be induced by poly I:C or LPS.	Poly I-C	79-87	ISG15 ubiquitin like modifier	Bos taurus	55-60
19367472-9	2009	Taken together, these results suggest that the expression of bISG15 can be induced in FBL cells stimulated with poly I:C or LPS, and IRF-3 may play a role in inducing the expression of ISG15 in FBL cells.	Poly I-C	112-120	ISG15 ubiquitin like modifier	Bos taurus	62-67
19501636-9	2009	In vitro as in vivo stimulations with Poly I:C and lipopolysaccharides (LPS) enhanced more dramatically nos2a than nos2b expression.	Poly I-C	38-46	nitric oxide synthase 2a, inducible	Danio rerio	104-109
19501636-9	2009	In vitro as in vivo stimulations with Poly I:C and lipopolysaccharides (LPS) enhanced more dramatically nos2a than nos2b expression.	Poly I-C	38-46	nitric oxide synthase 2b, inducible	Danio rerio	115-120
19851468-6	2009	The inhibitory effects of AM can also be nullified if mice or AMs are pretreated with poly I:C, which directly activate AMs and rDCs through toll-like receptors 3 (TLR3).	Poly I-C	86-94	toll-like receptor 3	Mus musculus	164-168
19710456-5	2009	We demonstrated that polyinosinic:polycytidylic acid consistently up-regulated both B7-2 and B7-H1 molecules on resident, migratory DCs from spleen and lymph nodes.	Poly I-C	21-52	CD86 molecule	Homo sapiens	84-88
19717524-6	2009	Mal deficiency boosted IL-6 induction by the TLR3 ligand polyinosinic-polycytidylic acid.	Poly I-C	57-88	toll-like receptor 3	Mus musculus	45-49
19717524-7	2009	Activation of JNK, but not p38 or IkappaB degradation, was similarly potentiated in response to polyinosinic-polycytidylic acid in Mal-deficient macrophages.	Poly I-C	96-127	mitogen-activated protein kinase 8	Mus musculus	14-17
19592095-5	2009	We report that cigarette smoke significantly suppresses the induction of IL-15 by poly I:C in human PBMCs.	Poly I-C	82-90	interleukin 15	Homo sapiens	73-78
19542247-2	2009	Toll-like receptor 3 (TLR3) recognizes viral double-stranded (ds) RNA such as polyinosinic-polycytidylic acid [poly(I:C)] and stimulates innate immune responses.	Poly I-C	78-109	toll like receptor 3	Homo sapiens	0-20
19542247-2	2009	Toll-like receptor 3 (TLR3) recognizes viral double-stranded (ds) RNA such as polyinosinic-polycytidylic acid [poly(I:C)] and stimulates innate immune responses.	Poly I-C	78-109	toll like receptor 3	Homo sapiens	22-26
19542247-7	2009	In human ASM, poly(I:C) (0.5 microg/ml) increased macrophage inflammatory protein-1alpha (MIP-1alpha) and RANTES that was prevented by a TLR3 monoclonal receptor antibody.	Poly I-C	14-23	C-C motif chemokine ligand 3	Homo sapiens	50-88
19542247-7	2009	In human ASM, poly(I:C) (0.5 microg/ml) increased macrophage inflammatory protein-1alpha (MIP-1alpha) and RANTES that was prevented by a TLR3 monoclonal receptor antibody.	Poly I-C	14-23	C-C motif chemokine ligand 3	Homo sapiens	90-100
19542247-7	2009	In human ASM, poly(I:C) (0.5 microg/ml) increased macrophage inflammatory protein-1alpha (MIP-1alpha) and RANTES that was prevented by a TLR3 monoclonal receptor antibody.	Poly I-C	14-23	C-C motif chemokine ligand 5	Homo sapiens	106-112
19542247-7	2009	In human ASM, poly(I:C) (0.5 microg/ml) increased macrophage inflammatory protein-1alpha (MIP-1alpha) and RANTES that was prevented by a TLR3 monoclonal receptor antibody.	Poly I-C	14-23	toll like receptor 3	Homo sapiens	137-141
19740321-7	2009	Additionally, poly(I:C) affected IL-1beta production and the migratory behaviour of Detroit-562.	Poly I-C	14-22	interleukin 1 beta	Homo sapiens	33-41
19740321-9	2009	Poly(I:C) induced a small increase in IL-1beta, IL-6 and IL-8 production in HNECs, while Pam(3)CSK(4) increased viability.	Poly I-C	0-8	interleukin 1 beta	Homo sapiens	38-46
19740321-9	2009	Poly(I:C) induced a small increase in IL-1beta, IL-6 and IL-8 production in HNECs, while Pam(3)CSK(4) increased viability.	Poly I-C	0-8	interleukin 6	Homo sapiens	48-52
19740321-9	2009	Poly(I:C) induced a small increase in IL-1beta, IL-6 and IL-8 production in HNECs, while Pam(3)CSK(4) increased viability.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
19592095-7	2009	In contrast to a profound increases in intracellular IL-15/IL-15Ralpha in poly I:C-treated PBMCs, exposure of PBMCs to smoke-conditioned media (SCM) diminished the IL-15/IL-15Ralpha production.	Poly I-C	74-82	interleukin 15	Homo sapiens	53-58
19592095-7	2009	In contrast to a profound increases in intracellular IL-15/IL-15Ralpha in poly I:C-treated PBMCs, exposure of PBMCs to smoke-conditioned media (SCM) diminished the IL-15/IL-15Ralpha production.	Poly I-C	74-82	interleukin 15 receptor subunit alpha	Homo sapiens	59-70
19631980-5	2009	RESULTS: Of all TLR ligands, we found that TLR3 ligation with polyI:C resulted in the biggest response with 5.6-fold increased signaling via NF-kappaB and 5.8-fold increased signaling via IRF.	Poly I-C	62-69	toll like receptor 3	Homo sapiens	43-47
19631980-5	2009	RESULTS: Of all TLR ligands, we found that TLR3 ligation with polyI:C resulted in the biggest response with 5.6-fold increased signaling via NF-kappaB and 5.8-fold increased signaling via IRF.	Poly I-C	62-69	tripartite motif containing 63	Homo sapiens	188-191
19635904-0	2009	Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways.	Poly I-C	0-8	CD8a molecule	Homo sapiens	43-52
19635904-0	2009	Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways.	Poly I-C	0-8	mitochondrial antiviral signaling protein	Homo sapiens	78-83
19635904-7	2009	Presence of IPS-1 and TRIF in dendritic cells (DCs), but not NK cells, was required for production of IFN-gamma to poly I:C in NK cells in vitro.	Poly I-C	115-123	interferon gamma	Homo sapiens	102-111
19635904-8	2009	Moreover CD8alpha(+) conventional dendritic cells (cDCs), but not CD8alpha(-) cDCs, expressed genes for type I IFNs, IL-6, and IL-12p40 in response to poly I:C stimulation, and were also responsible for inducing IFN-gamma production in NK cells.	Poly I-C	151-159	CD8a molecule	Homo sapiens	9-17
19635904-0	2009	Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways.	Poly I-C	0-8	TIR domain containing adaptor molecule 1	Homo sapiens	88-92
19635904-8	2009	Moreover CD8alpha(+) conventional dendritic cells (cDCs), but not CD8alpha(-) cDCs, expressed genes for type I IFNs, IL-6, and IL-12p40 in response to poly I:C stimulation, and were also responsible for inducing IFN-gamma production in NK cells.	Poly I-C	151-159	interleukin 6	Homo sapiens	117-121
19635904-8	2009	Moreover CD8alpha(+) conventional dendritic cells (cDCs), but not CD8alpha(-) cDCs, expressed genes for type I IFNs, IL-6, and IL-12p40 in response to poly I:C stimulation, and were also responsible for inducing IFN-gamma production in NK cells.	Poly I-C	151-159	interferon gamma	Homo sapiens	212-221
19635904-9	2009	Taken together, poly I:C activates the IPS-1- and TRIF-dependent pathways in CD8alpha(+) cDCs, which in turn leads to NK cell activation.	Poly I-C	16-24	mitochondrial antiviral signaling protein	Homo sapiens	39-44
19635904-2	2009	Polyinosinic-polycytidylic acid (poly I:C), a double-stranded RNA analog recognized by melanoma-differentiation associated gene 5 (MDA5) and TLR3, activates NK cells in vivo.	Poly I-C	0-31	interferon induced with helicase C domain 1	Homo sapiens	87-129
19635904-2	2009	Polyinosinic-polycytidylic acid (poly I:C), a double-stranded RNA analog recognized by melanoma-differentiation associated gene 5 (MDA5) and TLR3, activates NK cells in vivo.	Poly I-C	0-31	interferon induced with helicase C domain 1	Homo sapiens	131-135
19635904-2	2009	Polyinosinic-polycytidylic acid (poly I:C), a double-stranded RNA analog recognized by melanoma-differentiation associated gene 5 (MDA5) and TLR3, activates NK cells in vivo.	Poly I-C	0-31	toll like receptor 3	Homo sapiens	141-145
19635904-5	2009	In this study, we demonstrate that the IPS-1-dependent and the TRIF-dependent pathways are essential for NK cell activation to poly I:C stimulation in mice, whereas deficiency in either IPS-1 or TRIF only modestly impairs the poly I:C-induced NK cell activation.	Poly I-C	127-135	mitochondrial antiviral signaling protein	Mus musculus	39-44
19635904-9	2009	Taken together, poly I:C activates the IPS-1- and TRIF-dependent pathways in CD8alpha(+) cDCs, which in turn leads to NK cell activation.	Poly I-C	16-24	TIR domain containing adaptor molecule 1	Homo sapiens	50-54
19635904-5	2009	In this study, we demonstrate that the IPS-1-dependent and the TRIF-dependent pathways are essential for NK cell activation to poly I:C stimulation in mice, whereas deficiency in either IPS-1 or TRIF only modestly impairs the poly I:C-induced NK cell activation.	Poly I-C	127-135	toll-like receptor adaptor molecule 1	Mus musculus	63-67
19635904-9	2009	Taken together, poly I:C activates the IPS-1- and TRIF-dependent pathways in CD8alpha(+) cDCs, which in turn leads to NK cell activation.	Poly I-C	16-24	CD8a molecule	Homo sapiens	77-85
19635904-6	2009	Furthermore, both IPS-1 and TRIF contributed to suppression of implanted B16 tumor growth in response to poly I:C administration via NK cell activation.	Poly I-C	105-113	mitochondrial antiviral signaling protein	Homo sapiens	18-23
19635904-6	2009	Furthermore, both IPS-1 and TRIF contributed to suppression of implanted B16 tumor growth in response to poly I:C administration via NK cell activation.	Poly I-C	105-113	TIR domain containing adaptor molecule 1	Homo sapiens	28-32
19635904-7	2009	Presence of IPS-1 and TRIF in dendritic cells (DCs), but not NK cells, was required for production of IFN-gamma to poly I:C in NK cells in vitro.	Poly I-C	115-123	mitochondrial antiviral signaling protein	Homo sapiens	12-17
19635904-7	2009	Presence of IPS-1 and TRIF in dendritic cells (DCs), but not NK cells, was required for production of IFN-gamma to poly I:C in NK cells in vitro.	Poly I-C	115-123	TIR domain containing adaptor molecule 1	Homo sapiens	22-26
19242516-0	2009	Poly(I:C)-Treated human langerhans cells promote the differentiation of CD4+ T cells producing IFN-gamma and IL-10.	Poly I-C	0-9	CD4 molecule	Homo sapiens	72-75
19527294-5	2009	Treatment of bronchial epithelial cells with LL-37 and the TLR3 agonist polyI:C resulted in synergistic increases in IL-8 release and cytotoxicity.	Poly I-C	72-79	toll like receptor 3	Homo sapiens	59-63
19527294-5	2009	Treatment of bronchial epithelial cells with LL-37 and the TLR3 agonist polyI:C resulted in synergistic increases in IL-8 release and cytotoxicity.	Poly I-C	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
19242516-0	2009	Poly(I:C)-Treated human langerhans cells promote the differentiation of CD4+ T cells producing IFN-gamma and IL-10.	Poly I-C	0-9	interferon gamma	Homo sapiens	95-104
19242516-0	2009	Poly(I:C)-Treated human langerhans cells promote the differentiation of CD4+ T cells producing IFN-gamma and IL-10.	Poly I-C	0-9	interleukin 10	Homo sapiens	109-114
19242516-4	2009	Here we analyze the response of highly purified human LCs to poly(I:C), a synthetic mimetic of viral dsRNA recognized by TLR3.	Poly I-C	61-70	toll like receptor 3	Homo sapiens	121-125
19242516-6	2009	Furthermore, poly(I:C) significantly enhanced LC survival and induced them to produce CXCL10, IL-6, and IL-12 p40.	Poly I-C	13-21	C-X-C motif chemokine ligand 10	Homo sapiens	86-92
19242516-6	2009	Furthermore, poly(I:C) significantly enhanced LC survival and induced them to produce CXCL10, IL-6, and IL-12 p40.	Poly I-C	13-21	interleukin 6	Homo sapiens	94-98
19242516-9	2009	Most interestingly, we report here that poly(I:C)-treated LCs favored alloreactive CD4(+) T-cell differentiation toward a Th1 profile and concomitant differentiation of IL-10-producing CD4(+) T cells that might limit, at another time, the inflammatory response and subsequent tissue damage.	Poly I-C	40-49	CD4 molecule	Homo sapiens	83-86
19242516-9	2009	Most interestingly, we report here that poly(I:C)-treated LCs favored alloreactive CD4(+) T-cell differentiation toward a Th1 profile and concomitant differentiation of IL-10-producing CD4(+) T cells that might limit, at another time, the inflammatory response and subsequent tissue damage.	Poly I-C	40-49	negative elongation factor complex member C/D	Homo sapiens	122-125
19242516-9	2009	Most interestingly, we report here that poly(I:C)-treated LCs favored alloreactive CD4(+) T-cell differentiation toward a Th1 profile and concomitant differentiation of IL-10-producing CD4(+) T cells that might limit, at another time, the inflammatory response and subsequent tissue damage.	Poly I-C	40-49	interleukin 10	Homo sapiens	169-174
19242516-9	2009	Most interestingly, we report here that poly(I:C)-treated LCs favored alloreactive CD4(+) T-cell differentiation toward a Th1 profile and concomitant differentiation of IL-10-producing CD4(+) T cells that might limit, at another time, the inflammatory response and subsequent tissue damage.	Poly I-C	40-49	CD4 molecule	Homo sapiens	185-188
19564349-1	2009	Relative to several other toll-like receptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most effective adjuvant for Th1 CD4(+) T cell responses to a dendritic cell (DC)-targeted HIV gag protein vaccine in mice.	Poly I-C	103-110	negative elongation factor complex member C/D, Th1l	Mus musculus	150-153
19564349-1	2009	Relative to several other toll-like receptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most effective adjuvant for Th1 CD4(+) T cell responses to a dendritic cell (DC)-targeted HIV gag protein vaccine in mice.	Poly I-C	103-110	CD4 antigen	Mus musculus	154-157
19593403-6	2009	Furthermore, GTS-21 attenuated TNF production in monocytes stimulated with peptidoglycan, polyinosinic-polycytidylic acid, CpG, HMGB1 (high-mobility group box 1 protein), and advanced glycation end product-modified albumin.	Poly I-C	90-121	GTS	Homo sapiens	13-16
19187393-10	2009	Maturation and stimulation with TSLP or polyriboinosinic-polyribocytidylic acid in vitro upregulated the expression of both TSLPR and IL-7Ralpha chains in DC but not in chemoattractant receptor-homologous molecule expressed on Th2 cells(+) CD4(+) T cells.	Poly I-C	40-79	cytokine receptor like factor 2	Homo sapiens	124-129
19187393-10	2009	Maturation and stimulation with TSLP or polyriboinosinic-polyribocytidylic acid in vitro upregulated the expression of both TSLPR and IL-7Ralpha chains in DC but not in chemoattractant receptor-homologous molecule expressed on Th2 cells(+) CD4(+) T cells.	Poly I-C	40-79	interleukin 7 receptor	Homo sapiens	134-144
19187393-10	2009	Maturation and stimulation with TSLP or polyriboinosinic-polyribocytidylic acid in vitro upregulated the expression of both TSLPR and IL-7Ralpha chains in DC but not in chemoattractant receptor-homologous molecule expressed on Th2 cells(+) CD4(+) T cells.	Poly I-C	40-79	CD4 molecule	Homo sapiens	240-243
19593403-6	2009	Furthermore, GTS-21 attenuated TNF production in monocytes stimulated with peptidoglycan, polyinosinic-polycytidylic acid, CpG, HMGB1 (high-mobility group box 1 protein), and advanced glycation end product-modified albumin.	Poly I-C	90-121	tumor necrosis factor	Homo sapiens	31-34
19522763-3	2009	We have shown that all these cell lines express TLR3 on mRNA and protein level but it is only functional in Detroit 562 cell line since only in these cells poly I:C treatment triggered the IL-6 secretion.	Poly I-C	156-164	toll like receptor 3	Homo sapiens	48-52
19522763-3	2009	We have shown that all these cell lines express TLR3 on mRNA and protein level but it is only functional in Detroit 562 cell line since only in these cells poly I:C treatment triggered the IL-6 secretion.	Poly I-C	156-164	interleukin 6	Homo sapiens	189-193
19522763-4	2009	In addition, poly I:C treatment inhibited cell growth and triggered up-regulation of IL-12p40, IL-8 and Il-1alpha in Detroit 562 cell line.	Poly I-C	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
19522763-4	2009	In addition, poly I:C treatment inhibited cell growth and triggered up-regulation of IL-12p40, IL-8 and Il-1alpha in Detroit 562 cell line.	Poly I-C	13-21	interleukin 1 alpha	Homo sapiens	104-113
18988918-7	2009	Poly(I:C) significantly augmented the alpha-SMA expression (P < 0.01) and release of TGF-beta(1) (P < 0.01) compared with control.	Poly I-C	0-8	transforming growth factor beta 1	Homo sapiens	88-99
18988918-11	2009	Poly(I:C)-augmented TGF-beta(1) release was almost completely blocked by NF-kappaB inhibitors, but not by silencing IRF-3.	Poly I-C	0-9	transforming growth factor beta 1	Homo sapiens	20-31
19036857-0	2009	Astrocytes recognize intracellular polyinosinic-polycytidylic acid via MDA-5.	Poly I-C	35-66	interferon induced with helicase C domain 1	Mus musculus	71-76
19307177-2	2009	Here we demonstrate that BX795, a potent and relatively specific inhibitor of TBK1 and IKKepsilon, blocked the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3 and, hence, the production of interferon-beta in macrophages stimulated with poly(I:C) or lipopolysaccharide (LPS).	Poly I-C	291-299	TANK binding kinase 1	Homo sapiens	78-82
19307177-2	2009	Here we demonstrate that BX795, a potent and relatively specific inhibitor of TBK1 and IKKepsilon, blocked the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3 and, hence, the production of interferon-beta in macrophages stimulated with poly(I:C) or lipopolysaccharide (LPS).	Poly I-C	291-299	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	87-97
19307177-2	2009	Here we demonstrate that BX795, a potent and relatively specific inhibitor of TBK1 and IKKepsilon, blocked the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3 and, hence, the production of interferon-beta in macrophages stimulated with poly(I:C) or lipopolysaccharide (LPS).	Poly I-C	291-299	interferon regulatory factor 3	Homo sapiens	183-213
19284409-0	2009	Poly I:C-induced expression of intercellular adhesion molecule-1 in intestinal epithelial cells.	Poly I-C	0-8	intercellular adhesion molecule 1	Homo sapiens	31-64
19284409-5	2009	In the present study, we investigated whether poly I:C, an analogue of dsRNA, can stimulate the expression of ICAM-1 in IEC line, HT-29.	Poly I-C	46-54	intercellular adhesion molecule 1	Homo sapiens	110-116
19284409-6	2009	Poly I:C-stimulation up-regulated the expression of ICAM-1 mRNA by real-time polymerase chain reaction.	Poly I-C	0-8	intercellular adhesion molecule 1	Homo sapiens	52-58
19284409-8	2009	As the stimulation effect was reduced by pre-treatment of the cells with anti-TLR-3 antibody, poly I:C-binding signal was thought to be sensed by TLR-3 on the surface of HT-29.	Poly I-C	94-102	toll like receptor 3	Homo sapiens	78-83
19284409-8	2009	As the stimulation effect was reduced by pre-treatment of the cells with anti-TLR-3 antibody, poly I:C-binding signal was thought to be sensed by TLR-3 on the surface of HT-29.	Poly I-C	94-102	toll like receptor 3	Homo sapiens	146-151
19380818-7	2009	In addition, administration of poly(I:C), which is an innate immune agonist, to TMEV-infected mice during the innate immune response resulted in decreased myelin-specific CD4(+) T cell responses and reduced demyelinating disease.	Poly I-C	31-39	CD4 antigen	Mus musculus	171-174
19513781-8	2009	An increase in IL-6 secretion was also observed in cells stimulated with Alternaria extract after pretreatment with Poly IC.	Poly I-C	116-123	interleukin 6	Homo sapiens	15-19
19151401-6	2009	TSLP in corneal epithelial cells were largely induced in a concentration-dependent fashion by polyI:C, flagellin, and FSL-1, the ligands for toll-like receptor (TLR)-3, -5, and -6, respectively.	Poly I-C	94-101	thymic stromal lymphopoietin	Homo sapiens	0-4
19151401-6	2009	TSLP in corneal epithelial cells were largely induced in a concentration-dependent fashion by polyI:C, flagellin, and FSL-1, the ligands for toll-like receptor (TLR)-3, -5, and -6, respectively.	Poly I-C	94-101	toll like receptor 3	Homo sapiens	141-179
19151401-9	2009	IL-4 and -13 strongly synergized with PolyI:C, flagellin, and TNF-alpha to promote TSLP production in ex vivo tissues and in vitro cultures of corneal epithelium.	Poly I-C	38-45	thymic stromal lymphopoietin	Homo sapiens	83-87
19151401-10	2009	PolyI:C, flagellin, or TNF-alpha also induced NF-kappaB p65 protein nuclear translocation.	Poly I-C	0-7	RELA proto-oncogene, NF-kB subunit	Homo sapiens	56-59
19454667-4	2009	Our results show for the first time that KIR3DS1 expression on NK cells can be induced after exposure to stimulator cells (221, K562, EBV-B cell lines, and B cells), polyinosinic-polycytidylic acid, IL-15, or IL-2.	Poly I-C	166-197	killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1	Homo sapiens	41-48
19452017-1	2009	PURPOSE: The toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic-polyribocytidylic acid (poly(I:C)), and the activation of TLR3 is known to induce the production of type I interferon (IFN) and inflammatory cytokines/chemokines.	Poly I-C	103-142	toll like receptor 3	Homo sapiens	13-33
19452017-1	2009	PURPOSE: The toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic-polyribocytidylic acid (poly(I:C)), and the activation of TLR3 is known to induce the production of type I interferon (IFN) and inflammatory cytokines/chemokines.	Poly I-C	103-142	toll like receptor 3	Homo sapiens	35-39
19452017-1	2009	PURPOSE: The toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic-polyribocytidylic acid (poly(I:C)), and the activation of TLR3 is known to induce the production of type I interferon (IFN) and inflammatory cytokines/chemokines.	Poly I-C	103-142	toll like receptor 3	Homo sapiens	178-182
19452017-1	2009	PURPOSE: The toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic-polyribocytidylic acid (poly(I:C)), and the activation of TLR3 is known to induce the production of type I interferon (IFN) and inflammatory cytokines/chemokines.	Poly I-C	103-142	interferon alpha 1	Homo sapiens	220-243
19452017-10	2009	The poly(I:C)-induced expressions of IL-6 and IL-8 were down-regulated by both DEX and CsA, while the expressions of IFN-beta and TLR3 were suppressed by DEX alone.	Poly I-C	4-12	interleukin 6	Homo sapiens	37-41
19452017-10	2009	The poly(I:C)-induced expressions of IL-6 and IL-8 were down-regulated by both DEX and CsA, while the expressions of IFN-beta and TLR3 were suppressed by DEX alone.	Poly I-C	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
19452017-10	2009	The poly(I:C)-induced expressions of IL-6 and IL-8 were down-regulated by both DEX and CsA, while the expressions of IFN-beta and TLR3 were suppressed by DEX alone.	Poly I-C	4-12	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	87-90
19452017-10	2009	The poly(I:C)-induced expressions of IL-6 and IL-8 were down-regulated by both DEX and CsA, while the expressions of IFN-beta and TLR3 were suppressed by DEX alone.	Poly I-C	4-12	interferon beta 1	Homo sapiens	117-125
19452017-10	2009	The poly(I:C)-induced expressions of IL-6 and IL-8 were down-regulated by both DEX and CsA, while the expressions of IFN-beta and TLR3 were suppressed by DEX alone.	Poly I-C	4-12	toll like receptor 3	Homo sapiens	130-134
19196551-5	2009	Poly (I:C) induced activity was dependent on MDC and partially dependent on IL-12, consistent with accessory cell help.	Poly I-C	0-9	C-C motif chemokine ligand 22	Homo sapiens	45-48
19428835-6	2009	Similarly, maturation by Poly I:C leads to CD38high, CD83low DCs indicating a functional relationship between CD38, IFN-alpha and TLR3.	Poly I-C	25-33	CD83 molecule	Homo sapiens	53-57
19428835-6	2009	Similarly, maturation by Poly I:C leads to CD38high, CD83low DCs indicating a functional relationship between CD38, IFN-alpha and TLR3.	Poly I-C	25-33	CD38 molecule	Homo sapiens	43-47
19428835-6	2009	Similarly, maturation by Poly I:C leads to CD38high, CD83low DCs indicating a functional relationship between CD38, IFN-alpha and TLR3.	Poly I-C	25-33	interferon alpha 1	Homo sapiens	116-125
19428835-6	2009	Similarly, maturation by Poly I:C leads to CD38high, CD83low DCs indicating a functional relationship between CD38, IFN-alpha and TLR3.	Poly I-C	25-33	toll like receptor 3	Homo sapiens	130-134
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	22-30	chemokine (C-C motif) ligand 5	Mus musculus	143-149
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	22-30	chemokine (C-X-C motif) ligand 15	Mus musculus	152-165
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	22-30	chemokine (C-X-C motif) ligand 15	Mus musculus	167-171
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	22-30	tumor necrosis factor	Mus musculus	178-205
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	22-30	tumor necrosis factor	Mus musculus	207-216
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	22-30	interferon beta 1, fibroblast	Mus musculus	305-313
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	22-30	interleukin 6	Mus musculus	318-322
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	chemokine (C-C motif) ligand 5	Mus musculus	143-149
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	chemokine (C-X-C motif) ligand 15	Mus musculus	152-165
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	chemokine (C-X-C motif) ligand 15	Mus musculus	167-171
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	tumor necrosis factor	Mus musculus	178-205
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	tumor necrosis factor	Mus musculus	207-216
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	interferon beta 1, fibroblast	Mus musculus	305-313
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	interleukin 6	Mus musculus	318-322
19007809-4	2009	In mammals, poly I:C induces IFN-beta through the RIG-I/MDA5 or the TLR3 pathway, both of which are dependent on NF-kB.	Poly I-C	12-20	interferon beta 1	Homo sapiens	29-37
19007809-4	2009	In mammals, poly I:C induces IFN-beta through the RIG-I/MDA5 or the TLR3 pathway, both of which are dependent on NF-kB.	Poly I-C	12-20	DExD/H-box helicase 58	Homo sapiens	50-55
19007809-4	2009	In mammals, poly I:C induces IFN-beta through the RIG-I/MDA5 or the TLR3 pathway, both of which are dependent on NF-kB.	Poly I-C	12-20	interferon induced with helicase C domain 1	Homo sapiens	56-60
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	chemokine (C-C motif) ligand 5	Mus musculus	143-149
19007809-4	2009	In mammals, poly I:C induces IFN-beta through the RIG-I/MDA5 or the TLR3 pathway, both of which are dependent on NF-kB.	Poly I-C	12-20	toll like receptor 3	Homo sapiens	68-72
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	chemokine (C-X-C motif) ligand 15	Mus musculus	152-165
19007809-6	2009	The presence of an NF-kappaB site in their promoters and their strong up-regulation by poly I:C, suggest that salmon IFNa1/IFNa2 are induced through similar pathways as IFN-beta.	Poly I-C	87-95	interferon alpha 1	Homo sapiens	117-122
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	chemokine (C-X-C motif) ligand 15	Mus musculus	167-171
19007809-6	2009	The presence of an NF-kappaB site in their promoters and their strong up-regulation by poly I:C, suggest that salmon IFNa1/IFNa2 are induced through similar pathways as IFN-beta.	Poly I-C	87-95	interferon alpha 2	Homo sapiens	123-128
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	tumor necrosis factor	Mus musculus	178-205
19007809-6	2009	The presence of an NF-kappaB site in their promoters and their strong up-regulation by poly I:C, suggest that salmon IFNa1/IFNa2 are induced through similar pathways as IFN-beta.	Poly I-C	87-95	interferon beta 1	Homo sapiens	169-177
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	tumor necrosis factor	Mus musculus	207-216
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	interferon beta 1, fibroblast	Mus musculus	305-313
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	interleukin 6	Mus musculus	318-322
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	chemokine (C-C motif) ligand 5	Mus musculus	143-149
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	chemokine (C-X-C motif) ligand 15	Mus musculus	152-165
19063917-0	2009	An antiserum against Atlantic salmon IFNa1 detects IFN and neutralizes antiviral activity produced by poly I:C stimulated cells.	Poly I-C	102-110	interferon alpha 1	Salmo salar	37-42
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	chemokine (C-X-C motif) ligand 15	Mus musculus	167-171
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	tumor necrosis factor	Mus musculus	178-205
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	tumor necrosis factor	Mus musculus	207-216
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	interferon beta 1, fibroblast	Mus musculus	305-313
19036857-3	2009	Whereas extracellular poly I:C (naked poly I:C) mainly induced the expression of regulated on activation normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-alpha), intracellular delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.	Poly I-C	38-46	interleukin 6	Mus musculus	318-322
19036857-4	2009	Experiments with astrocytes from Toll-like receptor 3 (TLR-3) knockout mice indicated that naked poly I:C signals via a TLR-3-dependent NF-kappaB pathway.	Poly I-C	97-105	toll-like receptor 3	Mus musculus	33-53
19036857-4	2009	Experiments with astrocytes from Toll-like receptor 3 (TLR-3) knockout mice indicated that naked poly I:C signals via a TLR-3-dependent NF-kappaB pathway.	Poly I-C	97-105	toll-like receptor 3	Mus musculus	55-60
19036857-4	2009	Experiments with astrocytes from Toll-like receptor 3 (TLR-3) knockout mice indicated that naked poly I:C signals via a TLR-3-dependent NF-kappaB pathway.	Poly I-C	97-105	toll-like receptor 3	Mus musculus	120-125
19291698-3	2009	In A549 human lung epithelial cells, infection with influenza A virus or stimulation with poly(I:C)+IFN-gamma resulted in increased mRNA and protein levels of both IL-32 and iNOS, with subsequent release of NO.	Poly I-C	90-99	interleukin 32	Homo sapiens	164-169
19036857-5	2009	Complexed poly I:C induced the expression of the intracellular ds-RNA sensor proteins, retinoic acid inducible gene I (RIG-I), and melanoma differentiation-associated gene 5 (MDA-5).	Poly I-C	10-18	DEAD/H box helicase 58	Mus musculus	87-117
19291698-3	2009	In A549 human lung epithelial cells, infection with influenza A virus or stimulation with poly(I:C)+IFN-gamma resulted in increased mRNA and protein levels of both IL-32 and iNOS, with subsequent release of NO.	Poly I-C	90-99	nitric oxide synthase 2	Homo sapiens	174-178
19036857-5	2009	Complexed poly I:C induced the expression of the intracellular ds-RNA sensor proteins, retinoic acid inducible gene I (RIG-I), and melanoma differentiation-associated gene 5 (MDA-5).	Poly I-C	10-18	DEAD/H box helicase 58	Mus musculus	119-124
19036857-5	2009	Complexed poly I:C induced the expression of the intracellular ds-RNA sensor proteins, retinoic acid inducible gene I (RIG-I), and melanoma differentiation-associated gene 5 (MDA-5).	Poly I-C	10-18	interferon induced with helicase C domain 1	Mus musculus	131-173
19036857-5	2009	Complexed poly I:C induced the expression of the intracellular ds-RNA sensor proteins, retinoic acid inducible gene I (RIG-I), and melanoma differentiation-associated gene 5 (MDA-5).	Poly I-C	10-18	interferon induced with helicase C domain 1	Mus musculus	175-180
19282652-4	2009	An analogue of viral double-stranded RNA, polyinosinic:polycytidylic acid (poly I:C), which is recognized by TLR3, was injected into autoimmune-prone strains: MRL/Mp mice (MRL/+), MRL/Mp mice with a deficit of Fas (MRL/lpr) and MRL/Mp mice with a deficit of functional FasL (MRL/gld).	Poly I-C	75-83	toll-like receptor 3	Mus musculus	109-113
19166911-3	2009	Upon the activation of Toll-like receptor (TLR)-3 expressed in the neuronal cells by polyriboinosinic polyribocytidylic acid (PolyI:C), both IFN-lambda1 and IFN-lambda2/3 expression was significantly induced.	Poly I-C	85-124	interferon lambda 1	Homo sapiens	141-152
19166911-3	2009	Upon the activation of Toll-like receptor (TLR)-3 expressed in the neuronal cells by polyriboinosinic polyribocytidylic acid (PolyI:C), both IFN-lambda1 and IFN-lambda2/3 expression was significantly induced.	Poly I-C	85-124	interferon lambda 2	Homo sapiens	157-168
19239422-11	2009	CONCLUSION: We report that Poly[I:C] induces preterm delivery via TLR3-dependent manner.	Poly I-C	27-35	toll-like receptor 3	Mus musculus	66-70
19063917-5	2009	The antiserum also detected IFNa1 and neutralized 95-98% of the antiviral activity in supernatants of poly I:C stimulated salmon TO cells.	Poly I-C	102-110	interferon alpha 1	Salmo salar	28-33
19063917-6	2009	This suggests that IFNa1/IFNa2 are the major IFNs produced by poly I:C stimulated TO cells.	Poly I-C	62-70	interferon alpha 1	Salmo salar	19-24
19063917-6	2009	This suggests that IFNa1/IFNa2 are the major IFNs produced by poly I:C stimulated TO cells.	Poly I-C	62-70	interferon alpha 2	Salmo salar	25-30
19063917-8	2009	This shows that although IFNa1/IFNa2 are major IFNs secreted by poly I:C stimulated leucocytes, these cells can also produce additional molecules with IFN-like activity.	Poly I-C	64-72	interferon alpha 1	Salmo salar	25-30
19063917-8	2009	This shows that although IFNa1/IFNa2 are major IFNs secreted by poly I:C stimulated leucocytes, these cells can also produce additional molecules with IFN-like activity.	Poly I-C	64-72	interferon alpha 2	Salmo salar	31-36
19360120-4	2009	Poly I:C(12)U, another analogue, is less toxic but also less stable in vivo than poly I:C, and TLR3 is essential for its recognition.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	95-99
19154402-0	2009	Polyinosinic-polycytidylic acid liposome induces human hepatoma cells apoptosis which correlates to the up-regulation of RIG-I like receptors.	Poly I-C	0-31	DExD/H-box helicase 58	Homo sapiens	121-126
19304544-6	2009	The mRNA level of TLR3, TRIF, and IFN-beta were also increased following Poly I:C treatment in comparison with the control group.	Poly I-C	73-81	toll like receptor 3	Homo sapiens	18-22
19304544-6	2009	The mRNA level of TLR3, TRIF, and IFN-beta were also increased following Poly I:C treatment in comparison with the control group.	Poly I-C	73-81	TIR domain containing adaptor molecule 1	Homo sapiens	24-28
19304544-6	2009	The mRNA level of TLR3, TRIF, and IFN-beta were also increased following Poly I:C treatment in comparison with the control group.	Poly I-C	73-81	interferon beta 1	Homo sapiens	34-42
19304544-7	2009	CONCLUSION: Poly I:C can induce significant growth inhibition and apoptosis of SMMC-7721 cells in a dose- and time-dependent manner possibly by causing cell cycle arrest and TLR3 signaling pathway activation that leads to IFN-beta production and cell apoptosis.	Poly I-C	12-20	toll like receptor 3	Homo sapiens	174-178
19304544-7	2009	CONCLUSION: Poly I:C can induce significant growth inhibition and apoptosis of SMMC-7721 cells in a dose- and time-dependent manner possibly by causing cell cycle arrest and TLR3 signaling pathway activation that leads to IFN-beta production and cell apoptosis.	Poly I-C	12-20	interferon beta 1	Homo sapiens	222-230
19282652-4	2009	An analogue of viral double-stranded RNA, polyinosinic:polycytidylic acid (poly I:C), which is recognized by TLR3, was injected into autoimmune-prone strains: MRL/Mp mice (MRL/+), MRL/Mp mice with a deficit of Fas (MRL/lpr) and MRL/Mp mice with a deficit of functional FasL (MRL/gld).	Poly I-C	75-83	Fas ligand (TNF superfamily, member 6)	Mus musculus	269-273
19282652-6	2009	Using a pancreatic duct epithelial cell line MRL/S-1 newly established from the MRL/gld mouse that lacks FasL, we showed that treatment with poly I:C significantly induced the expression of Fas on the cultured cells.	Poly I-C	141-149	Fas ligand (TNF superfamily, member 6)	Mus musculus	105-109
19013198-8	2009	Poly I:C treatment led to activation of downstream transcription factors including interferon regulatory factor-3 (IRF-3) and NFkappaB.	Poly I-C	0-8	interferon regulatory factor 3	Homo sapiens	83-113
19013520-4	2009	DM-alpha-CyD inhibited inducible NO synthase (iNOS) and IFN-beta expression upon stimulation with Poly I:C.	Poly I-C	98-106	nitric oxide synthase 2, inducible	Mus musculus	23-44
19013520-4	2009	DM-alpha-CyD inhibited inducible NO synthase (iNOS) and IFN-beta expression upon stimulation with Poly I:C.	Poly I-C	98-106	nitric oxide synthase 2, inducible	Mus musculus	46-50
19013520-4	2009	DM-alpha-CyD inhibited inducible NO synthase (iNOS) and IFN-beta expression upon stimulation with Poly I:C.	Poly I-C	98-106	interferon beta 1, fibroblast	Mus musculus	56-64
19146941-5	2009	RESULTS: HaCaT cells induced the pro-inflammatory cytokines, interleukin-8 (IL-8) and/or interleukin-6 (IL-6) expressions after treatment with polyI:C or PGN.	Poly I-C	143-150	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
19146941-5	2009	RESULTS: HaCaT cells induced the pro-inflammatory cytokines, interleukin-8 (IL-8) and/or interleukin-6 (IL-6) expressions after treatment with polyI:C or PGN.	Poly I-C	143-150	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
19146941-5	2009	RESULTS: HaCaT cells induced the pro-inflammatory cytokines, interleukin-8 (IL-8) and/or interleukin-6 (IL-6) expressions after treatment with polyI:C or PGN.	Poly I-C	143-150	interleukin 6	Homo sapiens	89-102
19146941-5	2009	RESULTS: HaCaT cells induced the pro-inflammatory cytokines, interleukin-8 (IL-8) and/or interleukin-6 (IL-6) expressions after treatment with polyI:C or PGN.	Poly I-C	143-150	interleukin 6	Homo sapiens	104-108
19146941-6	2009	ACL inhibited the expression of IL-8 and IL-6 RNA and protein levels, and attenuated the activation of NF-kappaB and IRF3 after polyI:C treatment.	Poly I-C	128-135	interferon regulatory factor 3	Homo sapiens	117-121
19013198-8	2009	Poly I:C treatment led to activation of downstream transcription factors including interferon regulatory factor-3 (IRF-3) and NFkappaB.	Poly I-C	0-8	interferon regulatory factor 3	Homo sapiens	115-120
19036430-2	2009	We have developed a model vaccine formulation containing ovalbumin (OVA) and the double-stranded RNA analog poly(inosinic acid)-poly(cytidylic acid) (poly(I:C)), a TLR3 agonist.	Poly I-C	150-159	toll-like receptor 3	Mus musculus	164-168
19036430-3	2009	OVA and poly(I:C) were each ion-paired to cetyltrimethylammonium bromide (CTAB) to produce hydrophobic complexes, which were co-encapsulated in pH-sensitive polyketal (PK3) microparticles (1-3 microm) using a single emulsion method.	Poly I-C	8-17	pyruvate kinase, muscle	Mus musculus	168-171
18930547-0	2009	Cigarette smoke attenuation of poly I:C-induced innate antiviral responses in human PBMC is mainly due to inhibition of IFN-beta production.	Poly I-C	31-39	interferon beta 1	Homo sapiens	120-128
19100838-7	2009	Real time RT-PCR analysis confirmed that IFN-gamma gene expression was up-regulated in organs of cod injected with the dsRNA polyinosinic:polycytidylic acid (poly I:C), which is a strong inducer of type I IFNs.	Poly I-C	125-156	interferon gamma	Homo sapiens	41-50
18930547-1	2009	The cellular response to dsRNA or its synthetic analog polyinosinic-polycytidylic acid (poly I:C) results in IRF-3-, IRF-7- and NF-kB-mediated activation of type 1 IFNs and pro-inflammatory cytokines critical for innate antiviral immune responses.	Poly I-C	55-86	interferon regulatory factor 3	Homo sapiens	109-114
18930547-1	2009	The cellular response to dsRNA or its synthetic analog polyinosinic-polycytidylic acid (poly I:C) results in IRF-3-, IRF-7- and NF-kB-mediated activation of type 1 IFNs and pro-inflammatory cytokines critical for innate antiviral immune responses.	Poly I-C	55-86	interferon regulatory factor 7	Homo sapiens	117-122
18930547-1	2009	The cellular response to dsRNA or its synthetic analog polyinosinic-polycytidylic acid (poly I:C) results in IRF-3-, IRF-7- and NF-kB-mediated activation of type 1 IFNs and pro-inflammatory cytokines critical for innate antiviral immune responses.	Poly I-C	88-96	interferon regulatory factor 3	Homo sapiens	109-114
18930547-1	2009	The cellular response to dsRNA or its synthetic analog polyinosinic-polycytidylic acid (poly I:C) results in IRF-3-, IRF-7- and NF-kB-mediated activation of type 1 IFNs and pro-inflammatory cytokines critical for innate antiviral immune responses.	Poly I-C	88-96	interferon regulatory factor 7	Homo sapiens	117-122
19027047-7	2009	Importantly, brief conditioning of purified naive TCR transgenic OT-1 (CD8+) T cells in vitro with poly(I:C) induced activation of these cells in absence of antigen stimulation.	Poly I-C	99-107	CD8a molecule	Homo sapiens	71-74
19052084-4	2009	Using reporter assays, we show that BGLF4 effectively suppresses the activities of the poly(I:C)-stimulated IFN-beta promoter and IRF3-responsive element.	Poly I-C	87-96	tegument serine/threonine protein kinase	Human gammaherpesvirus 4	36-41
19052084-4	2009	Using reporter assays, we show that BGLF4 effectively suppresses the activities of the poly(I:C)-stimulated IFN-beta promoter and IRF3-responsive element.	Poly I-C	87-96	interferon beta 1	Homo sapiens	108-116
19028691-6	2009	Double-stranded PRNAs 50 nucleotides long as well as polyinosinic-polycytidylic acid activated the RNA-dependent protein kinase (PKR) and induced significant levels of IFN-beta and apoptosis, whereas shorter PRNAs and chemically synthesized dsRNAs did not.	Poly I-C	53-84	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	129-132
18971420-6	2009	Poly I:C could up-regulate tissue factor and down-regulate thrombomodulin expression on endothelial cells but not on monocytes.	Poly I-C	0-8	thrombomodulin	Mus musculus	59-73
18971420-7	2009	The response to poly I:C was diminished upon small interfering RNA (siRNA)-mediated inhibition of TLR3, but not other PRR.	Poly I-C	16-24	toll-like receptor 3	Mus musculus	98-102
18927430-4	2009	However, the induction of Cre recombinase in fII(lox) mice using the poly I:C-inducible Mx1-Cre system resulted in the rapid and near-complete recombination of the fII(lox) allele within the liver, the loss of circulating prothrombin, and profound derangements in coagulation function.	Poly I-C	69-77	coagulation factor II	Mus musculus	45-48
18927430-4	2009	However, the induction of Cre recombinase in fII(lox) mice using the poly I:C-inducible Mx1-Cre system resulted in the rapid and near-complete recombination of the fII(lox) allele within the liver, the loss of circulating prothrombin, and profound derangements in coagulation function.	Poly I-C	69-77	lysyl oxidase	Mus musculus	49-52
18927430-4	2009	However, the induction of Cre recombinase in fII(lox) mice using the poly I:C-inducible Mx1-Cre system resulted in the rapid and near-complete recombination of the fII(lox) allele within the liver, the loss of circulating prothrombin, and profound derangements in coagulation function.	Poly I-C	69-77	MX dynamin-like GTPase 1	Mus musculus	88-91
18927430-4	2009	However, the induction of Cre recombinase in fII(lox) mice using the poly I:C-inducible Mx1-Cre system resulted in the rapid and near-complete recombination of the fII(lox) allele within the liver, the loss of circulating prothrombin, and profound derangements in coagulation function.	Poly I-C	69-77	coagulation factor II	Mus musculus	164-167
18927430-4	2009	However, the induction of Cre recombinase in fII(lox) mice using the poly I:C-inducible Mx1-Cre system resulted in the rapid and near-complete recombination of the fII(lox) allele within the liver, the loss of circulating prothrombin, and profound derangements in coagulation function.	Poly I-C	69-77	lysyl oxidase	Mus musculus	168-171
18927430-4	2009	However, the induction of Cre recombinase in fII(lox) mice using the poly I:C-inducible Mx1-Cre system resulted in the rapid and near-complete recombination of the fII(lox) allele within the liver, the loss of circulating prothrombin, and profound derangements in coagulation function.	Poly I-C	69-77	coagulation factor II	Mus musculus	222-233
19028691-6	2009	Double-stranded PRNAs 50 nucleotides long as well as polyinosinic-polycytidylic acid activated the RNA-dependent protein kinase (PKR) and induced significant levels of IFN-beta and apoptosis, whereas shorter PRNAs and chemically synthesized dsRNAs did not.	Poly I-C	53-84	interferon beta 1	Homo sapiens	168-176
19028691-8	2009	PKR, in addition to IPS-1 and IRF3 but not TRIF, was required for maximal type I IFN-beta induction and the induction of apoptosis by both transfected PRNAs and polyinosinic-polycytidylic acid.	Poly I-C	161-192	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	0-3
19086992-4	2009	RESULTS: After stimulation by polyI:C, human uNK cells interact with autologous uterine macrophages and produce interferon-gamma in an NKG2D-dependent manner.	Poly I-C	30-37	interferon gamma	Homo sapiens	112-128
19086992-4	2009	RESULTS: After stimulation by polyI:C, human uNK cells interact with autologous uterine macrophages and produce interferon-gamma in an NKG2D-dependent manner.	Poly I-C	30-37	killer cell lectin like receptor K1	Homo sapiens	135-140
19081639-3	2009	Placental CD11c(+) DCs were potently activated by the TLR3-agonist polyinosinic polycytidylic acid [poly (I:C)], subsequently causing increased expression of co-stimulatory molecules.	Poly I-C	67-98	integrin alpha X	Mus musculus	10-15
18778729-6	2009	Recombinant salmon IFN-alpha1 and poly I:C proved to be potent inducers of IRF-7 in Atlantic salmon TO cells, and poly I:C also induced the gene in head kidney and liver of Atlantic salmon.	Poly I-C	34-42	interferon regulatory factor 7	Salmo salar	75-80
18778729-7	2009	STAT1 was also induced by IFN, but was only weakly induced by poly I:C stimulation in vitro.	Poly I-C	62-70	signal transducer and activator of transcription 1b	Salmo salar	0-5
19111017-7	2009	Posttreatment with polyI:C also caused activation of hepatic Kupffer cells (KCs) and natural killer (NK) cells and upregulated multiple proapoptotic factors, including tumor necrosis factor-alpha (TNF-alpha), NK receptor group 2, member D (NKG2D), and Fas ligand (FasL).	Poly I-C	19-26	tumor necrosis factor	Mus musculus	168-195
19111017-7	2009	Posttreatment with polyI:C also caused activation of hepatic Kupffer cells (KCs) and natural killer (NK) cells and upregulated multiple proapoptotic factors, including tumor necrosis factor-alpha (TNF-alpha), NK receptor group 2, member D (NKG2D), and Fas ligand (FasL).	Poly I-C	19-26	tumor necrosis factor	Mus musculus	197-206
19111017-7	2009	Posttreatment with polyI:C also caused activation of hepatic Kupffer cells (KCs) and natural killer (NK) cells and upregulated multiple proapoptotic factors, including tumor necrosis factor-alpha (TNF-alpha), NK receptor group 2, member D (NKG2D), and Fas ligand (FasL).	Poly I-C	19-26	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	209-238
19111017-7	2009	Posttreatment with polyI:C also caused activation of hepatic Kupffer cells (KCs) and natural killer (NK) cells and upregulated multiple proapoptotic factors, including tumor necrosis factor-alpha (TNF-alpha), NK receptor group 2, member D (NKG2D), and Fas ligand (FasL).	Poly I-C	19-26	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	240-245
19111017-7	2009	Posttreatment with polyI:C also caused activation of hepatic Kupffer cells (KCs) and natural killer (NK) cells and upregulated multiple proapoptotic factors, including tumor necrosis factor-alpha (TNF-alpha), NK receptor group 2, member D (NKG2D), and Fas ligand (FasL).	Poly I-C	19-26	Fas ligand (TNF superfamily, member 6)	Mus musculus	252-262
19111017-7	2009	Posttreatment with polyI:C also caused activation of hepatic Kupffer cells (KCs) and natural killer (NK) cells and upregulated multiple proapoptotic factors, including tumor necrosis factor-alpha (TNF-alpha), NK receptor group 2, member D (NKG2D), and Fas ligand (FasL).	Poly I-C	19-26	Fas ligand (TNF superfamily, member 6)	Mus musculus	264-268
19000789-6	2009	Guggulsterone inhibited nuclear factor-kappaB and IRF3 activation induced by lipopolysaccharide or poly[I:C] and activation of IRF3 induced by the overexpression of TRIF, TBK1 or constitutively active IRF3.	Poly I-C	99-107	interferon regulatory factor 3	Homo sapiens	50-54
19056108-4	2009	OBJECTIVES: We investigated TSLP"s release from primary human keratinocytes stimulated with a Toll-like receptor (TLR) 3 ligand, polyinosinic-polycytidylic acid, which mimics viral double-stranded RNA (dsRNA), and its modulation by cytokines.	Poly I-C	129-160	thymic stromal lymphopoietin	Homo sapiens	28-32
18683246-1	2009	We have previously reported that polyinosinic-polycytidylic acids [poly(I:C)], a synthetic toll-like receptor 3 (TLR3) agonist, induce Schwann cell activation, which exerts neurotoxic effects on sensory neurons.	Poly I-C	33-65	toll-like receptor 3	Rattus norvegicus	91-111
18683246-1	2009	We have previously reported that polyinosinic-polycytidylic acids [poly(I:C)], a synthetic toll-like receptor 3 (TLR3) agonist, induce Schwann cell activation, which exerts neurotoxic effects on sensory neurons.	Poly I-C	33-65	toll-like receptor 3	Rattus norvegicus	113-117
18683246-6	2009	VIP also inhibited the poly(I:C)-induced p38 activation that is responsible for the iNOS gene expression in Schwann cells.	Poly I-C	23-32	vasoactive intestinal peptide	Rattus norvegicus	0-3
18683246-6	2009	VIP also inhibited the poly(I:C)-induced p38 activation that is responsible for the iNOS gene expression in Schwann cells.	Poly I-C	23-32	mitogen activated protein kinase 14	Rattus norvegicus	41-44
18683246-6	2009	VIP also inhibited the poly(I:C)-induced p38 activation that is responsible for the iNOS gene expression in Schwann cells.	Poly I-C	23-32	nitric oxide synthase 2	Rattus norvegicus	84-88
19081639-3	2009	Placental CD11c(+) DCs were potently activated by the TLR3-agonist polyinosinic polycytidylic acid [poly (I:C)], subsequently causing increased expression of co-stimulatory molecules.	Poly I-C	67-98	toll-like receptor 3	Mus musculus	54-58
19081639-3	2009	Placental CD11c(+) DCs were potently activated by the TLR3-agonist polyinosinic polycytidylic acid [poly (I:C)], subsequently causing increased expression of co-stimulatory molecules.	Poly I-C	100-110	integrin alpha X	Mus musculus	10-15
19081639-3	2009	Placental CD11c(+) DCs were potently activated by the TLR3-agonist polyinosinic polycytidylic acid [poly (I:C)], subsequently causing increased expression of co-stimulatory molecules.	Poly I-C	100-110	toll-like receptor 3	Mus musculus	54-58
19252739-1	2009	The Toll-like receptor (TLR) 3 plays a critical role in mammalian innate immune response against viral attacks by recognizing double-stranded RNA (dsRNA) or its synthetic analog polyinosinic-polycytidylic acid (poly (IratioC)).	Poly I-C	178-209	toll like receptor 3	Homo sapiens	24-27
18805586-8	2008	Poly I:C and type I rIFN also induced IRF3 and IRF7 expression in a trout fibroblast cell line (RTG-2).	Poly I-C	0-8	interferon regulatory factor 3	Oncorhynchus mykiss	38-42
18849341-4	2008	Furthermore, we found that FLN29(-/-) mice exhibited increased susceptibility to poly(I:C)-induced septic shock compared with WT mice.	Poly I-C	81-90	TRAF type zinc finger domain containing 1	Mus musculus	27-32
19017955-4	2008	While the responsive CD8 T cells expanded comparably in both wild-type and TLR3(-/-) mice, differentiation of effector CD8 T cells was enhanced by poly(I:C) in the TLR3(-/-) mice.	Poly I-C	147-155	toll-like receptor 3	Mus musculus	164-168
18782327-6	2008	However, only the combination of poly(I:C) + CD40L induced complete functional activation of the whole DC population, assessing IL-12p70 production, allostimulatory activity, migratory response to CCL19 and T helper 1-polarizing capacity.	Poly I-C	33-42	C-C motif chemokine ligand 19	Homo sapiens	197-202
18805586-8	2008	Poly I:C and type I rIFN also induced IRF3 and IRF7 expression in a trout fibroblast cell line (RTG-2).	Poly I-C	0-8	interferon regulatory factor 7	Oncorhynchus mykiss	47-51
18779317-8	2008	Furthermore, the poly(I-C)-induced phosphorylation of IkappaB-alpha, nuclear translocation of NF-kappaB, and phosphorylation of interferon regulatory transcription factor 3, were drastically reduced in HCT116 p53(-/-) cells, indicating a dysregulation of the two signaling pathways governed by TLR3.	Poly I-C	17-26	NFKB inhibitor alpha	Homo sapiens	54-67
18818378-4	2008	We therefore investigated the role of STAT1 in adhesive interactions that occur between leukocytes and polyI:C-induced mucosal smooth muscle cells (M-SMCs).	Poly I-C	103-110	signal transducer and activator of transcription 1	Mus musculus	38-43
18818378-5	2008	Activation of STAT1 was observed after the polyI:C treatment of M-SMCs.	Poly I-C	43-50	signal transducer and activator of transcription 1	Mus musculus	14-19
18818378-6	2008	Specific phosphorylation of tyrosine and serine residues of STAT1 was observed in polyI:C-treated, but not untreated, M-SMC cultures.	Poly I-C	82-89	signal transducer and activator of transcription 1	Mus musculus	60-65
18818378-8	2008	PolyI:C-induced, HA-mediated leukocyte adhesion to colon SMCs from STAT1-null mice was significantly decreased compared with that from wild-type control mice.	Poly I-C	0-7	signal transducer and activator of transcription 1	Mus musculus	67-72
18755278-0	2008	Expressional induction of Paralichthys olivaceus cathepsin B gene in response to virus, poly I:C and lipopolysaccharide.	Poly I-C	88-96	cathepsin B	Homo sapiens	49-60
18949355-8	2008	Transfected Poly I:C also synergistically augmented TRAIL-induced apoptosis, but only with low levels of transfected Poly I:C was IFN-beta production not observed.	Poly I-C	12-20	TNF superfamily member 10	Homo sapiens	52-57
18809435-9	2008	Both mAbs to SHPS-1, but not that to CD47, also inhibited the lipopolysaccharide- or polyinosinic-polycytidylic acid-induced production of TNF-alpha by DCs.	Poly I-C	85-116	signal-regulatory protein alpha	Mus musculus	13-19
18809435-9	2008	Both mAbs to SHPS-1, but not that to CD47, also inhibited the lipopolysaccharide- or polyinosinic-polycytidylic acid-induced production of TNF-alpha by DCs.	Poly I-C	85-116	tumor necrosis factor	Mus musculus	139-148
18790062-6	2008	The expression of the black rockfish ISG15 molecule was induced in the peripheral blood leukocytes (PBLs) from 1 to 12h following poly I:C stimulation, with a peak at 6h post-stimulation.	Poly I-C	130-138	ISG15 ubiquitin like modifier	Homo sapiens	37-42
18779317-8	2008	Furthermore, the poly(I-C)-induced phosphorylation of IkappaB-alpha, nuclear translocation of NF-kappaB, and phosphorylation of interferon regulatory transcription factor 3, were drastically reduced in HCT116 p53(-/-) cells, indicating a dysregulation of the two signaling pathways governed by TLR3.	Poly I-C	17-26	nuclear factor kappa B subunit 1	Homo sapiens	94-103
18779317-8	2008	Furthermore, the poly(I-C)-induced phosphorylation of IkappaB-alpha, nuclear translocation of NF-kappaB, and phosphorylation of interferon regulatory transcription factor 3, were drastically reduced in HCT116 p53(-/-) cells, indicating a dysregulation of the two signaling pathways governed by TLR3.	Poly I-C	17-26	tumor protein p53	Homo sapiens	209-212
18779317-8	2008	Furthermore, the poly(I-C)-induced phosphorylation of IkappaB-alpha, nuclear translocation of NF-kappaB, and phosphorylation of interferon regulatory transcription factor 3, were drastically reduced in HCT116 p53(-/-) cells, indicating a dysregulation of the two signaling pathways governed by TLR3.	Poly I-C	17-26	toll like receptor 3	Homo sapiens	294-298
18779317-9	2008	Consequently, induction of interleukin-8 and beta interferon after poly(I-C) stimulation was impaired in HCT116 p53(-/-) cells.	Poly I-C	67-76	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
18779317-9	2008	Consequently, induction of interleukin-8 and beta interferon after poly(I-C) stimulation was impaired in HCT116 p53(-/-) cells.	Poly I-C	67-76	tumor protein p53	Homo sapiens	112-115
18832709-8	2008	Furthermore, poly(I:C)-induced IFN-beta production is inhibited by pretreatment of cells with B- and C-type oligodeoxynucleotides (ODNs) but not with TLR7/8 ligands.	Poly I-C	13-21	interferon beta 1	Homo sapiens	31-39
18813114-3	2008	DC2 were differentiated from monocytes in the presence of CsA and were matured with viral or bacterial agonists (poly[I:C] or lipopolysaccharide).	Poly I-C	113-121	monoacylglycerol O-acyltransferase 1	Homo sapiens	0-3
18586328-8	2008	In addition, poly(I:C)-induced porcine IFN-beta promoter activation in PK-15 cells was significantly reduced by siRNA targeting IPS-1, indicating that IPS-1 is an important immunoregulator in the porcine innate immune system.	Poly I-C	13-22	interferon beta 1	Sus scrofa	39-47
18586328-8	2008	In addition, poly(I:C)-induced porcine IFN-beta promoter activation in PK-15 cells was significantly reduced by siRNA targeting IPS-1, indicating that IPS-1 is an important immunoregulator in the porcine innate immune system.	Poly I-C	13-22	mitochondrial antiviral signaling protein	Mus musculus	128-133
18586328-8	2008	In addition, poly(I:C)-induced porcine IFN-beta promoter activation in PK-15 cells was significantly reduced by siRNA targeting IPS-1, indicating that IPS-1 is an important immunoregulator in the porcine innate immune system.	Poly I-C	13-22	mitochondrial antiviral signaling protein	Mus musculus	151-156
18813114-5	2008	In contrast, cytokine responses were altered with inhibition of interleukin-10 production in poly(I:C)-matured DC2.	Poly I-C	93-101	interleukin 10	Homo sapiens	64-78
18813114-5	2008	In contrast, cytokine responses were altered with inhibition of interleukin-10 production in poly(I:C)-matured DC2.	Poly I-C	93-101	monoacylglycerol O-acyltransferase 1	Homo sapiens	111-114
18813114-7	2008	Internalization was impaired in treated DC2, and CsA decreased the T-cell proliferative capacity of DC2 matured with poly(I:C), but not with lipopolysaccharide.	Poly I-C	117-125	monoacylglycerol O-acyltransferase 1	Homo sapiens	100-103
18725521-4	2008	In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively.	Poly I-C	61-69	interleukin 1 beta	Homo sapiens	130-142
18657446-6	2008	In these cells, as observed in vivo, Poly I:C significantly induced the expression of IL-8R, increase that came along with an increase in the chemotactic activity towards IL-8.	Poly I-C	37-45	interleukin 8 receptor	Oncorhynchus mykiss	86-91
18657446-6	2008	In these cells, as observed in vivo, Poly I:C significantly induced the expression of IL-8R, increase that came along with an increase in the chemotactic activity towards IL-8.	Poly I-C	37-45	putative cxc chemokine	Oncorhynchus mykiss	86-90
18725521-4	2008	In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively.	Poly I-C	61-69	toll like receptor 4	Homo sapiens	160-164
18725521-4	2008	In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively.	Poly I-C	61-69	toll like receptor 3	Homo sapiens	271-275
18725521-4	2008	In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively.	Poly I-C	61-69	toll like receptor 4	Homo sapiens	280-284
18725521-6	2008	Surprisingly, poly(I:C)- and LPS-induced pro-IL-1beta processing still occurred in caspase-1-deficient cells.	Poly I-C	14-23	interleukin 1 beta	Homo sapiens	41-53
18725521-6	2008	Surprisingly, poly(I:C)- and LPS-induced pro-IL-1beta processing still occurred in caspase-1-deficient cells.	Poly I-C	14-23	caspase 1	Homo sapiens	83-92
18641653-4	2008	Although morphologically normal, TRADD-deficient mice were resistant to toxicity induced by TNF, lipopolysaccharide and polyinosinic-polycytidylic acid.	Poly I-C	120-151	TNFRSF1A-associated via death domain	Mus musculus	33-38
18713996-9	2008	Poly(I-C)-induced expression of IP-10, RANTES, and IFN-beta mRNA was decreased in MKK4- or MKK7-deficient FLS.	Poly I-C	0-8	C-X-C motif chemokine ligand 10	Homo sapiens	32-37
18713996-9	2008	Poly(I-C)-induced expression of IP-10, RANTES, and IFN-beta mRNA was decreased in MKK4- or MKK7-deficient FLS.	Poly I-C	0-8	C-C motif chemokine ligand 5	Homo sapiens	39-45
18713996-9	2008	Poly(I-C)-induced expression of IP-10, RANTES, and IFN-beta mRNA was decreased in MKK4- or MKK7-deficient FLS.	Poly I-C	0-8	interferon beta 1	Homo sapiens	51-59
18713996-9	2008	Poly(I-C)-induced expression of IP-10, RANTES, and IFN-beta mRNA was decreased in MKK4- or MKK7-deficient FLS.	Poly I-C	0-8	mitogen-activated protein kinase kinase 4	Homo sapiens	82-86
18713996-11	2008	MKK7, but not MKK4 deficiency, significantly decreased poly(I-C)-mediated IRF3 dimerization, DNA binding, and IFN-sensitive response element-mediated gene transcription.	Poly I-C	55-64	mitogen-activated protein kinase kinase 7	Homo sapiens	0-4
18713996-11	2008	MKK7, but not MKK4 deficiency, significantly decreased poly(I-C)-mediated IRF3 dimerization, DNA binding, and IFN-sensitive response element-mediated gene transcription.	Poly I-C	55-64	interferon regulatory factor 3	Homo sapiens	74-78
18611945-4	2008	We found that RSV initial attachment to cells blocked polyI:C-mediated IFN-beta induction, and this early IFN-beta-modulating event was abrogated by antibodies against envelope proteins of RSV, demonstrating the presence of a IFN-regulatory mode by early RSV attachment to host cells.	Poly I-C	54-61	interferon beta 1	Homo sapiens	71-79
18641654-5	2008	Moreover, TRADD deficiency inhibited poly(I:C)-mediated RIP1 ubiquitination and activation of NF-kappaB and mitogen-activated protein kinase signaling in fibroblasts but not in bone marrow macrophages.	Poly I-C	37-46	TNFRSF1A-associated via death domain	Mus musculus	10-15
18641654-5	2008	Moreover, TRADD deficiency inhibited poly(I:C)-mediated RIP1 ubiquitination and activation of NF-kappaB and mitogen-activated protein kinase signaling in fibroblasts but not in bone marrow macrophages.	Poly I-C	37-46	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	56-60
18641654-5	2008	Moreover, TRADD deficiency inhibited poly(I:C)-mediated RIP1 ubiquitination and activation of NF-kappaB and mitogen-activated protein kinase signaling in fibroblasts but not in bone marrow macrophages.	Poly I-C	37-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	94-103
18541719-6	2008	Moreover, mf interfered with NF-kappaB activation (particularly p65 and p50) following stimulation with poly I:C or LPS.	Poly I-C	104-112	RELA proto-oncogene, NF-kB subunit	Homo sapiens	64-67
18541719-6	2008	Moreover, mf interfered with NF-kappaB activation (particularly p65 and p50) following stimulation with poly I:C or LPS.	Poly I-C	104-112	nuclear factor kappa B subunit 1	Homo sapiens	72-75
18463533-7	2008	Although poly(I:C)-based maturation induced substantial IL-12p70 secretion, poly(I:C)-DC also secreted low levels of IL-10 and showed a significantly higher expression of functionally active indoleamine-2,3-dioxygenase than PGE2-DC, which might mediate immune inhibitory functions.	Poly I-C	76-85	interleukin 10	Homo sapiens	117-122
18660424-1	2008	PURPOSE: Polyinosinic-polycytidylic acid [poly(I:C)], an analog of viral double-stranded RNA, interacts with Toll-like receptor (TLR)-3 and thereby elicits immunoinflammatory responses characteristic of viral infection.	Poly I-C	9-40	toll like receptor 3	Homo sapiens	109-135
18660424-1	2008	PURPOSE: Polyinosinic-polycytidylic acid [poly(I:C)], an analog of viral double-stranded RNA, interacts with Toll-like receptor (TLR)-3 and thereby elicits immunoinflammatory responses characteristic of viral infection.	Poly I-C	42-51	toll like receptor 3	Homo sapiens	109-135
18660424-7	2008	RESULTS: Poly(I:C) induced the up-regulation of TLR3, the release of IL-6, IL-8, G-CSF, MIP-1beta, eotaxin, and RANTES, and the expression of ICAM-1 and VCAM-1 in corneal fibroblasts.	Poly I-C	9-17	toll like receptor 3	Homo sapiens	48-52
18660424-7	2008	RESULTS: Poly(I:C) induced the up-regulation of TLR3, the release of IL-6, IL-8, G-CSF, MIP-1beta, eotaxin, and RANTES, and the expression of ICAM-1 and VCAM-1 in corneal fibroblasts.	Poly I-C	9-17	interleukin 6	Homo sapiens	69-73
18660424-7	2008	RESULTS: Poly(I:C) induced the up-regulation of TLR3, the release of IL-6, IL-8, G-CSF, MIP-1beta, eotaxin, and RANTES, and the expression of ICAM-1 and VCAM-1 in corneal fibroblasts.	Poly I-C	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
18660424-7	2008	RESULTS: Poly(I:C) induced the up-regulation of TLR3, the release of IL-6, IL-8, G-CSF, MIP-1beta, eotaxin, and RANTES, and the expression of ICAM-1 and VCAM-1 in corneal fibroblasts.	Poly I-C	9-17	colony stimulating factor 3	Homo sapiens	81-86
18660424-7	2008	RESULTS: Poly(I:C) induced the up-regulation of TLR3, the release of IL-6, IL-8, G-CSF, MIP-1beta, eotaxin, and RANTES, and the expression of ICAM-1 and VCAM-1 in corneal fibroblasts.	Poly I-C	9-17	C-C motif chemokine ligand 4	Homo sapiens	88-97
18660424-7	2008	RESULTS: Poly(I:C) induced the up-regulation of TLR3, the release of IL-6, IL-8, G-CSF, MIP-1beta, eotaxin, and RANTES, and the expression of ICAM-1 and VCAM-1 in corneal fibroblasts.	Poly I-C	9-17	C-C motif chemokine ligand 11	Homo sapiens	99-106
18660424-7	2008	RESULTS: Poly(I:C) induced the up-regulation of TLR3, the release of IL-6, IL-8, G-CSF, MIP-1beta, eotaxin, and RANTES, and the expression of ICAM-1 and VCAM-1 in corneal fibroblasts.	Poly I-C	9-17	C-C motif chemokine ligand 5	Homo sapiens	112-118
18654661-7	2008	The effects of a combination of CS and poly(I:C) were associated with early induction of type I IFN and IL-18, later induction of IL-12/IL-23 p40 and IFN-gamma, and the activation of double-stranded RNA-dependent protein kinase (PKR) and eukaryotic initiation factor-2alpha (eIF2alpha).	Poly I-C	39-48	interleukin 18	Mus musculus	104-109
18654661-7	2008	The effects of a combination of CS and poly(I:C) were associated with early induction of type I IFN and IL-18, later induction of IL-12/IL-23 p40 and IFN-gamma, and the activation of double-stranded RNA-dependent protein kinase (PKR) and eukaryotic initiation factor-2alpha (eIF2alpha).	Poly I-C	39-48	interferon gamma	Mus musculus	150-159
18654661-7	2008	The effects of a combination of CS and poly(I:C) were associated with early induction of type I IFN and IL-18, later induction of IL-12/IL-23 p40 and IFN-gamma, and the activation of double-stranded RNA-dependent protein kinase (PKR) and eukaryotic initiation factor-2alpha (eIF2alpha).	Poly I-C	39-48	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	229-232
18654661-7	2008	The effects of a combination of CS and poly(I:C) were associated with early induction of type I IFN and IL-18, later induction of IL-12/IL-23 p40 and IFN-gamma, and the activation of double-stranded RNA-dependent protein kinase (PKR) and eukaryotic initiation factor-2alpha (eIF2alpha).	Poly I-C	39-48	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	275-284
18559731-8	2008	Combined exposure of cells to poly IC, IL-4, and TNF-alpha resulted in substantial amounts of TARC release into the culture medium.	Poly I-C	30-37	C-C motif chemokine ligand 17	Homo sapiens	94-98
19669308-4	2008	We then examined the response of cultured HIBECs to a TLR3 ligand, polyinosinic-polycytidylic acid (polyI:C).	Poly I-C	67-98	toll like receptor 3	Homo sapiens	54-58
19669308-4	2008	We then examined the response of cultured HIBECs to a TLR3 ligand, polyinosinic-polycytidylic acid (polyI:C).	Poly I-C	100-107	toll like receptor 3	Homo sapiens	54-58
19669308-8	2008	In contrast, transfection of HIBECs with polyI:C induced a marked increase in mRNAs encoding a variety of chemokines/cytokines, including IFN-beta, IL-6, and TNF-alpha.	Poly I-C	41-48	interferon beta 1	Homo sapiens	138-146
19669308-8	2008	In contrast, transfection of HIBECs with polyI:C induced a marked increase in mRNAs encoding a variety of chemokines/cytokines, including IFN-beta, IL-6, and TNF-alpha.	Poly I-C	41-48	interleukin 6	Homo sapiens	148-152
19669308-8	2008	In contrast, transfection of HIBECs with polyI:C induced a marked increase in mRNAs encoding a variety of chemokines/cytokines, including IFN-beta, IL-6, and TNF-alpha.	Poly I-C	41-48	tumor necrosis factor	Homo sapiens	158-167
19669308-9	2008	The induction of IFN-beta mRNA was efficiently inhibited by an siRNA against MAVS but not against TICAM-1, indicating that the main signaling pathway for IFN-beta induction following polyI:C transfection is via retinoic acid-inducible gene I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) in HIBECs.	Poly I-C	183-190	interferon beta 1	Homo sapiens	17-25
19669308-9	2008	The induction of IFN-beta mRNA was efficiently inhibited by an siRNA against MAVS but not against TICAM-1, indicating that the main signaling pathway for IFN-beta induction following polyI:C transfection is via retinoic acid-inducible gene I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) in HIBECs.	Poly I-C	183-190	mitochondrial antiviral signaling protein	Homo sapiens	77-81
19669308-9	2008	The induction of IFN-beta mRNA was efficiently inhibited by an siRNA against MAVS but not against TICAM-1, indicating that the main signaling pathway for IFN-beta induction following polyI:C transfection is via retinoic acid-inducible gene I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) in HIBECs.	Poly I-C	183-190	interferon beta 1	Homo sapiens	154-162
19669308-9	2008	The induction of IFN-beta mRNA was efficiently inhibited by an siRNA against MAVS but not against TICAM-1, indicating that the main signaling pathway for IFN-beta induction following polyI:C transfection is via retinoic acid-inducible gene I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) in HIBECs.	Poly I-C	183-190	DExD/H-box helicase 58	Homo sapiens	211-241
19669308-9	2008	The induction of IFN-beta mRNA was efficiently inhibited by an siRNA against MAVS but not against TICAM-1, indicating that the main signaling pathway for IFN-beta induction following polyI:C transfection is via retinoic acid-inducible gene I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) in HIBECs.	Poly I-C	183-190	DExD/H-box helicase 58	Homo sapiens	243-248
19669308-9	2008	The induction of IFN-beta mRNA was efficiently inhibited by an siRNA against MAVS but not against TICAM-1, indicating that the main signaling pathway for IFN-beta induction following polyI:C transfection is via retinoic acid-inducible gene I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) in HIBECs.	Poly I-C	183-190	interferon induced with helicase C domain 1	Homo sapiens	250-292
19669308-9	2008	The induction of IFN-beta mRNA was efficiently inhibited by an siRNA against MAVS but not against TICAM-1, indicating that the main signaling pathway for IFN-beta induction following polyI:C transfection is via retinoic acid-inducible gene I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) in HIBECs.	Poly I-C	183-190	interferon induced with helicase C domain 1	Homo sapiens	294-298
18471880-5	2008	Both RIG-I/MDA5 and TLR3 can bind polyriboinosinic:polyribocytidylic acid (poly(I:C)), the synthetic analog of viral dsRNA, and mediate type I IFN production.	Poly I-C	75-83	DExD/H-box helicase 58	Homo sapiens	5-10
18471880-5	2008	Both RIG-I/MDA5 and TLR3 can bind polyriboinosinic:polyribocytidylic acid (poly(I:C)), the synthetic analog of viral dsRNA, and mediate type I IFN production.	Poly I-C	75-83	interferon induced with helicase C domain 1	Homo sapiens	11-15
18471880-5	2008	Both RIG-I/MDA5 and TLR3 can bind polyriboinosinic:polyribocytidylic acid (poly(I:C)), the synthetic analog of viral dsRNA, and mediate type I IFN production.	Poly I-C	75-83	toll like receptor 3	Homo sapiens	20-24
18587636-0	2008	LPS and poly I:C induce chromatin modifications at a novel upstream region of the IL-23 p19 promoter.	Poly I-C	8-16	interleukin 23 subunit alpha	Homo sapiens	82-91
18587636-2	2008	We found that poly I:C, LPS, flagellin, and zymogen activated significant IL-23 production in primary human monocytes.	Poly I-C	14-22	interleukin 23 subunit alpha	Homo sapiens	74-79
18660424-7	2008	RESULTS: Poly(I:C) induced the up-regulation of TLR3, the release of IL-6, IL-8, G-CSF, MIP-1beta, eotaxin, and RANTES, and the expression of ICAM-1 and VCAM-1 in corneal fibroblasts.	Poly I-C	9-17	intercellular adhesion molecule 1	Homo sapiens	142-148
18660424-7	2008	RESULTS: Poly(I:C) induced the up-regulation of TLR3, the release of IL-6, IL-8, G-CSF, MIP-1beta, eotaxin, and RANTES, and the expression of ICAM-1 and VCAM-1 in corneal fibroblasts.	Poly I-C	9-17	vascular cell adhesion molecule 1	Homo sapiens	153-159
18660424-9	2008	Poly(I:C)-induced expression of IL-6, IL-8, G-CSF, MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II.	Poly I-C	0-8	interleukin 6	Homo sapiens	32-36
18660424-9	2008	Poly(I:C)-induced expression of IL-6, IL-8, G-CSF, MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
18660424-9	2008	Poly(I:C)-induced expression of IL-6, IL-8, G-CSF, MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II.	Poly I-C	0-8	colony stimulating factor 3	Homo sapiens	44-49
18660424-9	2008	Poly(I:C)-induced expression of IL-6, IL-8, G-CSF, MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II.	Poly I-C	0-8	C-C motif chemokine ligand 4	Homo sapiens	51-60
18660424-9	2008	Poly(I:C)-induced expression of IL-6, IL-8, G-CSF, MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II.	Poly I-C	0-8	C-C motif chemokine ligand 5	Homo sapiens	72-78
18660424-9	2008	Poly(I:C)-induced expression of IL-6, IL-8, G-CSF, MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II.	Poly I-C	0-8	intercellular adhesion molecule 1	Homo sapiens	84-90
18660424-9	2008	Poly(I:C)-induced expression of IL-6, IL-8, G-CSF, MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II.	Poly I-C	0-8	mitogen-activated protein kinase 8	Homo sapiens	171-174
18660424-10	2008	CONCLUSIONS: Poly(I:C) induces the up-regulation of TLR3, the MAPK-dependent expression of proinflammatory cytokines, chemokines, and adhesion molecules and the activation of NF-kappaB in human corneal fibroblasts.	Poly I-C	13-21	toll like receptor 3	Homo sapiens	52-56
18660424-10	2008	CONCLUSIONS: Poly(I:C) induces the up-regulation of TLR3, the MAPK-dependent expression of proinflammatory cytokines, chemokines, and adhesion molecules and the activation of NF-kappaB in human corneal fibroblasts.	Poly I-C	13-21	nuclear factor kappa B subunit 1	Homo sapiens	175-184
18641315-8	2008	Specific targeting of Ro52 using short hairpin RNA rescues IRF3 degradation following polyI:C-stimulation of HEK293T cells, with a subsequent increase in IFN-beta production.	Poly I-C	86-93	tripartite motif-containing 21	Mus musculus	22-26
18641315-8	2008	Specific targeting of Ro52 using short hairpin RNA rescues IRF3 degradation following polyI:C-stimulation of HEK293T cells, with a subsequent increase in IFN-beta production.	Poly I-C	86-93	interferon regulatory factor 3	Homo sapiens	59-63
18566014-6	2008	By using pharmacological and genetic approaches, we demonstrate the involvement of TLR3 in poly (I:C)-induced effects.	Poly I-C	91-101	toll like receptor 3	Homo sapiens	83-87
18566014-8	2008	To our knowledge, this is the first report describing a role of PKC-alpha in poly (I:C)-mediated apoptosis.	Poly I-C	77-87	protein kinase C alpha	Homo sapiens	64-73
18490443-2	2008	Using a human embryonic kidney 293T cell line to express human TLR3, we determined that poly(I-C)-induced signal could be significantly inhibited by single-stranded DNAs (ssDNAs), but not ssRNA or dsDNA.	Poly I-C	88-97	toll like receptor 3	Homo sapiens	63-67
18490443-7	2008	The ssDNAs also decrease the levels of several cytokines produced by the human bronchial epithelial cell line BEAS-2B and by human peripheral blood mononuclear cells in response to poly(I-C) stimulation of native TLR3.	Poly I-C	181-190	toll like receptor 3	Homo sapiens	213-217
18424663-5	2008	CBMCs responded to stimulation with polyinosinic.polycytidylic acid by producing a distinct chemokine profile, including CCL4, CXCL8, and CXCL10.	Poly I-C	36-67	C-C motif chemokine ligand 4	Homo sapiens	121-125
18424663-5	2008	CBMCs responded to stimulation with polyinosinic.polycytidylic acid by producing a distinct chemokine profile, including CCL4, CXCL8, and CXCL10.	Poly I-C	36-67	C-X-C motif chemokine ligand 8	Homo sapiens	127-132
18424663-5	2008	CBMCs responded to stimulation with polyinosinic.polycytidylic acid by producing a distinct chemokine profile, including CCL4, CXCL8, and CXCL10.	Poly I-C	36-67	C-X-C motif chemokine ligand 10	Homo sapiens	138-144
18471880-9	2008	PI3K, whose activity is essential for activation of IRF3, is recruited to the phosphorylated tyrosine residues of SIRPalpha upon poly(I:C) stimulation, which lead to a reduction in the activity of the downstream kinase AKT.	Poly I-C	129-138	interferon regulatory factor 3	Homo sapiens	52-56
18471880-9	2008	PI3K, whose activity is essential for activation of IRF3, is recruited to the phosphorylated tyrosine residues of SIRPalpha upon poly(I:C) stimulation, which lead to a reduction in the activity of the downstream kinase AKT.	Poly I-C	129-138	signal regulatory protein alpha	Homo sapiens	114-123
18350548-6	2008	Poly (I:C) (a synthetic TLR3 agonist) and reovirus-1 (a dsRNA virus) induced high expression of BAFF mRNA (multiplied by a factor of 246 +/- 39 (SEM) and 347 +/- 66, respectively) and of BAFF protein secretion (58.49 +/- 4.34 pg/mL and 69.73 +/- 5.67).	Poly I-C	0-9	TNF superfamily member 13b	Homo sapiens	96-100
18252870-0	2008	poly(I:C) and LPS induce distinct IRF3 and NF-kappaB signaling during type-I IFN and TNF responses in human macrophages.	Poly I-C	0-9	interferon regulatory factor 3	Homo sapiens	34-38
18252870-0	2008	poly(I:C) and LPS induce distinct IRF3 and NF-kappaB signaling during type-I IFN and TNF responses in human macrophages.	Poly I-C	0-9	tumor necrosis factor	Homo sapiens	43-88
18383392-7	2008	Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis (OA), and expression of miR-155 could be further induced by TNFalpha, interleukin-1beta, lipopolysaccharide, poly(I-C), and bacterial lipoprotein.	Poly I-C	230-238	microRNA 155	Homo sapiens	32-39
18383392-7	2008	Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis (OA), and expression of miR-155 could be further induced by TNFalpha, interleukin-1beta, lipopolysaccharide, poly(I-C), and bacterial lipoprotein.	Poly I-C	230-238	microRNA 146a	Homo sapiens	44-52
18383392-7	2008	Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis (OA), and expression of miR-155 could be further induced by TNFalpha, interleukin-1beta, lipopolysaccharide, poly(I-C), and bacterial lipoprotein.	Poly I-C	230-238	microRNA 155	Homo sapiens	145-152
18383392-7	2008	Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis (OA), and expression of miR-155 could be further induced by TNFalpha, interleukin-1beta, lipopolysaccharide, poly(I-C), and bacterial lipoprotein.	Poly I-C	230-238	interleukin 1 beta	Homo sapiens	191-208
18331798-4	2008	We report that also polyinosinic-polycytidylic acid [poly(I:C)], a TLR-3 agonist, induces systemic TNF in mice.	Poly I-C	20-51	toll-like receptor 3	Mus musculus	67-72
18331798-4	2008	We report that also polyinosinic-polycytidylic acid [poly(I:C)], a TLR-3 agonist, induces systemic TNF in mice.	Poly I-C	20-51	tumor necrosis factor	Mus musculus	99-102
18331798-4	2008	We report that also polyinosinic-polycytidylic acid [poly(I:C)], a TLR-3 agonist, induces systemic TNF in mice.	Poly I-C	53-62	toll-like receptor 3	Mus musculus	67-72
18331798-4	2008	We report that also polyinosinic-polycytidylic acid [poly(I:C)], a TLR-3 agonist, induces systemic TNF in mice.	Poly I-C	53-62	tumor necrosis factor	Mus musculus	99-102
18331798-6	2008	Our results provide direct evidence that poly(I:C) induces TNF-alpha in d-GalN sensitized mice, which leads to severe, acute, and TNF-dependent lethal hepatitis.	Poly I-C	41-50	tumor necrosis factor	Mus musculus	59-68
18331798-6	2008	Our results provide direct evidence that poly(I:C) induces TNF-alpha in d-GalN sensitized mice, which leads to severe, acute, and TNF-dependent lethal hepatitis.	Poly I-C	41-50	galanin and GMAP prepropeptide	Mus musculus	74-78
18331798-6	2008	Our results provide direct evidence that poly(I:C) induces TNF-alpha in d-GalN sensitized mice, which leads to severe, acute, and TNF-dependent lethal hepatitis.	Poly I-C	41-50	tumor necrosis factor	Mus musculus	59-62
18342575-4	2008	Poly(I:C)/Dotap induced three times more IFN-alpha, when compared to TLR7-stimulation (R848) and four times less, when compared to TLR9-stimulation.	Poly I-C	0-9	interferon alpha 1	Homo sapiens	41-50
18342575-4	2008	Poly(I:C)/Dotap induced three times more IFN-alpha, when compared to TLR7-stimulation (R848) and four times less, when compared to TLR9-stimulation.	Poly I-C	0-9	toll like receptor 7	Homo sapiens	69-73
18342575-5	2008	Dotap (mediator of cellular uptake) dramatically increased Poly(I:C)-induced IFN-alpha production.	Poly I-C	59-68	interferon alpha 1	Homo sapiens	77-86
18342575-6	2008	Sorting experiments and ELISpot assays revealed that monocytes and not myeloid DCs are the main IFN-alpha source after Poly(I:C)/Dotap stimulation.	Poly I-C	119-128	interferon alpha 1	Homo sapiens	96-105
18252870-7	2008	poly(I:C), on the other hand, induced a strong and long-lasting (>12 h) IFN-beta mRNA and protein response, particularly when transfected, whereas only a protracted TNF response was observed when poly(I:C) was transfected.	Poly I-C	0-8	interferon beta 1	Homo sapiens	75-83
18350548-6	2008	Poly (I:C) (a synthetic TLR3 agonist) and reovirus-1 (a dsRNA virus) induced high expression of BAFF mRNA (multiplied by a factor of 246 +/- 39 (SEM) and 347 +/- 66, respectively) and of BAFF protein secretion (58.49 +/- 4.34 pg/mL and 69.73 +/- 5.67).	Poly I-C	0-9	TNF superfamily member 13b	Homo sapiens	187-191
17928888-2	2008	Viral double-stranded RNA and its synthetic analogue polyriboinosinic-polyribocytidylic acid (poly-IC) are recognized via multiple pathways involving the receptors Toll-like receptor 3 (TLR3), protein kinase R (PKR), and the recently described cytosolic RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	53-92	toll like receptor 3	Homo sapiens	164-184
18253710-11	2008	Poly(I:C)-conditioned DCs promoted accumulation of phosphorylated SHP-2, the intracellular phosphatase mediating PD-1 inhibitory effects.	Poly I-C	0-9	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	66-71
18253710-11	2008	Poly(I:C)-conditioned DCs promoted accumulation of phosphorylated SHP-2, the intracellular phosphatase mediating PD-1 inhibitory effects.	Poly I-C	0-9	programmed cell death 1	Homo sapiens	113-117
18031817-2	2008	As shown in in vitro studies, while polyinosinic-polycytidylic acid [poly (I:C)] and LPS, TLR3 and TLR4 ligands, respectively, can induce HMGB1 release from macrophages, CpG DNA, a TLR 9 ligand, does not.	Poly I-C	36-67	toll-like receptor 3	Mus musculus	90-94
18031817-2	2008	As shown in in vitro studies, while polyinosinic-polycytidylic acid [poly (I:C)] and LPS, TLR3 and TLR4 ligands, respectively, can induce HMGB1 release from macrophages, CpG DNA, a TLR 9 ligand, does not.	Poly I-C	36-67	high mobility group box 1	Mus musculus	138-143
18031817-2	2008	As shown in in vitro studies, while polyinosinic-polycytidylic acid [poly (I:C)] and LPS, TLR3 and TLR4 ligands, respectively, can induce HMGB1 release from macrophages, CpG DNA, a TLR 9 ligand, does not.	Poly I-C	36-67	toll-like receptor 9	Mus musculus	181-186
18031817-2	2008	As shown in in vitro studies, while polyinosinic-polycytidylic acid [poly (I:C)] and LPS, TLR3 and TLR4 ligands, respectively, can induce HMGB1 release from macrophages, CpG DNA, a TLR 9 ligand, does not.	Poly I-C	69-79	high mobility group box 1	Mus musculus	138-143
18031817-2	2008	As shown in in vitro studies, while polyinosinic-polycytidylic acid [poly (I:C)] and LPS, TLR3 and TLR4 ligands, respectively, can induce HMGB1 release from macrophages, CpG DNA, a TLR 9 ligand, does not.	Poly I-C	69-79	toll-like receptor 9	Mus musculus	181-186
17928888-2	2008	Viral double-stranded RNA and its synthetic analogue polyriboinosinic-polyribocytidylic acid (poly-IC) are recognized via multiple pathways involving the receptors Toll-like receptor 3 (TLR3), protein kinase R (PKR), and the recently described cytosolic RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	53-92	toll like receptor 3	Homo sapiens	186-190
17928888-2	2008	Viral double-stranded RNA and its synthetic analogue polyriboinosinic-polyribocytidylic acid (poly-IC) are recognized via multiple pathways involving the receptors Toll-like receptor 3 (TLR3), protein kinase R (PKR), and the recently described cytosolic RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	53-92	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	193-209
17928888-2	2008	Viral double-stranded RNA and its synthetic analogue polyriboinosinic-polyribocytidylic acid (poly-IC) are recognized via multiple pathways involving the receptors Toll-like receptor 3 (TLR3), protein kinase R (PKR), and the recently described cytosolic RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	53-92	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	211-214
17928888-2	2008	Viral double-stranded RNA and its synthetic analogue polyriboinosinic-polyribocytidylic acid (poly-IC) are recognized via multiple pathways involving the receptors Toll-like receptor 3 (TLR3), protein kinase R (PKR), and the recently described cytosolic RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	53-92	DExD/H-box helicase 58	Homo sapiens	300-305
17928888-2	2008	Viral double-stranded RNA and its synthetic analogue polyriboinosinic-polyribocytidylic acid (poly-IC) are recognized via multiple pathways involving the receptors Toll-like receptor 3 (TLR3), protein kinase R (PKR), and the recently described cytosolic RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	53-92	interferon induced with helicase C domain 1	Homo sapiens	311-353
17928888-2	2008	Viral double-stranded RNA and its synthetic analogue polyriboinosinic-polyribocytidylic acid (poly-IC) are recognized via multiple pathways involving the receptors Toll-like receptor 3 (TLR3), protein kinase R (PKR), and the recently described cytosolic RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	53-92	interferon induced with helicase C domain 1	Homo sapiens	355-359
18191426-8	2008	Poly I:C treatment dose-dependently reduced wheel-running activity, and induced an increase in plasma IFN-beta in mice.	Poly I-C	0-8	interferon beta 1, fibroblast	Mus musculus	102-110
18194666-0	2008	Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice.	Poly I-C	41-72	CD4 antigen	Mus musculus	162-165
18194666-0	2008	Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice.	Poly I-C	41-72	forkhead box P3	Mus musculus	166-171
18365016-4	2008	To demonstrate wounding-induced activation of TG2 in vivo, the toll-like receptor 3 ligand, polyinosinic-polycytidylic acid (poly(I:C)), was injected in mice to trigger small intestinal injury.	Poly I-C	92-123	transglutaminase 2, C polypeptide	Mus musculus	46-49
18365016-4	2008	To demonstrate wounding-induced activation of TG2 in vivo, the toll-like receptor 3 ligand, polyinosinic-polycytidylic acid (poly(I:C)), was injected in mice to trigger small intestinal injury.	Poly I-C	125-134	transglutaminase 2, C polypeptide	Mus musculus	46-49
18250418-5	2008	Poly (I:C)-induced IFN-beta and LPS-induced CCL5 production were also suppressed by PGE(2).	Poly I-C	0-10	interferon beta 1, fibroblast	Mus musculus	19-27
18055568-3	2008	In this study, we show that cigarette smoke-conditioned medium (SCM) dose-dependently inhibits in vitro IFN-gamma production by polyinosinic:polycytidylic acid (poly I:C)-activated PBMC and NK cells isolated from nonsmoking individuals.	Poly I-C	128-159	interferon gamma	Homo sapiens	104-113
18055568-3	2008	In this study, we show that cigarette smoke-conditioned medium (SCM) dose-dependently inhibits in vitro IFN-gamma production by polyinosinic:polycytidylic acid (poly I:C)-activated PBMC and NK cells isolated from nonsmoking individuals.	Poly I-C	161-169	interferon gamma	Homo sapiens	104-113
18055568-4	2008	Similarly, SCM attenuated poly I:C-induced TNF-alpha production by PBMC and NK cells.	Poly I-C	26-34	tumor necrosis factor	Homo sapiens	43-52
18055568-6	2008	PBMC and NK cells isolated from smokers displayed significant reduction of IFN-gamma and TNF-alpha secretions compared with nonsmokers in response to poly I:C activation.	Poly I-C	150-158	interferon gamma	Homo sapiens	75-84
18055568-6	2008	PBMC and NK cells isolated from smokers displayed significant reduction of IFN-gamma and TNF-alpha secretions compared with nonsmokers in response to poly I:C activation.	Poly I-C	150-158	tumor necrosis factor	Homo sapiens	89-98
18057004-3	2008	We found that poly(I:C) induced a pronounced cellular infiltration into the corneal stroma, which was TLR3- and TRIF-dependent.	Poly I-C	14-22	toll-like receptor 3	Mus musculus	102-106
18057004-3	2008	We found that poly(I:C) induced a pronounced cellular infiltration into the corneal stroma, which was TLR3- and TRIF-dependent.	Poly I-C	14-22	toll-like receptor adaptor molecule 2	Mus musculus	112-116
18295941-2	2008	We found that the efficiency of cross-priming in mice after vaccination with biodegradable poly(D,L-lactide-co-glycolide) microspheres (MSs) was enhanced when ovalbumin was coencapsulated together with either a CpG oligonucleotide or polyI:C as compared to co-inoculation of ovalbumin-bearing MS with soluble or separately encapsulated adjuvants.	Poly I-C	234-241	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	159-168
18250418-5	2008	Poly (I:C)-induced IFN-beta and LPS-induced CCL5 production were also suppressed by PGE(2).	Poly I-C	0-10	chemokine (C-C motif) ligand 5	Mus musculus	44-48
18166357-8	2008	Poly I:C activation of NK cell cytotoxicity against HSCs was attenuated in ethanol-fed mice compared with pair-fed mice, which was due to reduced natural killer group 2 member D (NKG2D), tumor necrosis factor-related apoptosis-inducing ligand, and IFN-gamma expression on NK cells from ethanol-fed mice.	Poly I-C	0-8	interferon gamma	Mus musculus	248-257
18204787-6	2008	Correspondingly, overexpression of human TLR3 in mouse fibroblasts resulted in an upregulation of c-Myc and increased sensitivity for PolyI:C-induced cell proliferation.	Poly I-C	134-141	toll like receptor 3	Homo sapiens	41-45
18306459-9	2008	When cells were stimulated by poly (I:C), 3-phenyl-propenal significantly decreased TLR3 and MyD88 expression.	Poly I-C	30-40	toll-like receptor 3	Mus musculus	84-88
18306459-9	2008	When cells were stimulated by poly (I:C), 3-phenyl-propenal significantly decreased TLR3 and MyD88 expression.	Poly I-C	30-40	myeloid differentiation primary response gene 88	Mus musculus	93-98
18184197-3	2008	Interleukin (IL)-6 in response to TLR3 and TLR4 ligands such as polyinosinic-polycytidylic acid and lipopolysaccharide was significantly compromised in HCV-infected women.	Poly I-C	64-95	toll like receptor 3	Homo sapiens	34-38
18184197-3	2008	Interleukin (IL)-6 in response to TLR3 and TLR4 ligands such as polyinosinic-polycytidylic acid and lipopolysaccharide was significantly compromised in HCV-infected women.	Poly I-C	64-95	toll like receptor 4	Homo sapiens	43-47
17920124-6	2008	The grouper IL-1beta was constitutively expressed in almost all tissues examined, and was augmented in PBL after the addition of LPS or Poly I:C in vitro.	Poly I-C	136-144	interleukin 1 beta	Homo sapiens	12-20
18199340-0	2008	Poly I:C enhances cycloheximide-induced apoptosis of tumor cells through TLR3 pathway.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	73-77
18199340-8	2008	Blockade of TLR3 recognition with anti-TLR3 antibody greatly attenuated the proapoptotic effects of poly I:C on tumor cells cultured with CHX.	Poly I-C	100-108	toll like receptor 3	Homo sapiens	12-16
18199340-8	2008	Blockade of TLR3 recognition with anti-TLR3 antibody greatly attenuated the proapoptotic effects of poly I:C on tumor cells cultured with CHX.	Poly I-C	100-108	toll like receptor 3	Homo sapiens	39-43
18085664-3	2008	Toll-like receptors (TLR) agonists such as bacterial lipopeptide, polyI:C, lipopolysaccharide and unmethylated CpG DNA all induced up-regulation of Notch1 in primary and macrophage-like cell lines.	Poly I-C	66-73	notch receptor 1	Homo sapiens	148-154
18406365-5	2008	We have demonstrated expression of TLR3 in Vgamma9Vdelta2 T cells and striking costimulatory effects of the ligand polyinosinic-polycytidylic acid (polyI:C) on TCR-stimulated IFN-gamma production.	Poly I-C	115-146	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	160-163
18406365-5	2008	We have demonstrated expression of TLR3 in Vgamma9Vdelta2 T cells and striking costimulatory effects of the ligand polyinosinic-polycytidylic acid (polyI:C) on TCR-stimulated IFN-gamma production.	Poly I-C	115-146	interferon gamma	Homo sapiens	175-184
18406365-5	2008	We have demonstrated expression of TLR3 in Vgamma9Vdelta2 T cells and striking costimulatory effects of the ligand polyinosinic-polycytidylic acid (polyI:C) on TCR-stimulated IFN-gamma production.	Poly I-C	148-155	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	160-163
18406365-5	2008	We have demonstrated expression of TLR3 in Vgamma9Vdelta2 T cells and striking costimulatory effects of the ligand polyinosinic-polycytidylic acid (polyI:C) on TCR-stimulated IFN-gamma production.	Poly I-C	148-155	interferon gamma	Homo sapiens	175-184
17981792-2	2008	Polyinosinic:polycytidylic acids [poly(I:C)] is a synthetic mimetic of dsRNA and functions through an endosomal receptor, Toll-like receptor (TLR) 3 or cytosolic receptors.	Poly I-C	0-32	toll-like receptor 3	Mus musculus	142-145
17851256-5	2008	It was assessed whether ASM cells respond to polyinosinic-polycytidylic acid (poly I:C), a synthetic analog of dsRNA, with alterations in M2R, M3R, H1R, and CysLT1R expression.	Poly I-C	45-76	cysteinyl leukotriene receptor 1	Homo sapiens	157-164
17851256-5	2008	It was assessed whether ASM cells respond to polyinosinic-polycytidylic acid (poly I:C), a synthetic analog of dsRNA, with alterations in M2R, M3R, H1R, and CysLT1R expression.	Poly I-C	78-86	cysteinyl leukotriene receptor 1	Homo sapiens	157-164
17981792-2	2008	Polyinosinic:polycytidylic acids [poly(I:C)] is a synthetic mimetic of dsRNA and functions through an endosomal receptor, Toll-like receptor (TLR) 3 or cytosolic receptors.	Poly I-C	34-43	toll-like receptor 3	Mus musculus	142-145
17982052-4	2007	The TLR4- and MyD88-dependent pathways are required for LPS to shorten allograft survival, whereas polyinosinic:polycytidylic acid mediates its effects through a TLR3-independent pathway.	Poly I-C	99-130	toll-like receptor 3	Mus musculus	162-166
18352910-3	2008	Poly IC-induced ISG20 expression was inhibited by LY294002, an inhibitor of PI3K, or by RNA interference against IFN regulatory factor three.	Poly I-C	0-7	interferon stimulated exonuclease gene 20	Homo sapiens	16-21
18039525-5	2007	Poly I:C induced an increase in B1 and B2 receptor mRNA levels in BEAS-2B and primary human normal bronchial epithelial cells.	Poly I-C	0-8	bradykinin receptor B1	Homo sapiens	32-50
18039525-6	2007	At the cell surface, only B1 receptor expression was increased by Poly I:C.	Poly I-C	66-74	bradykinin receptor B1	Homo sapiens	26-37
18039525-7	2007	Furthermore, pretreatment of BEAS-2B cells with Poly I:C enhanced the induction of phospho-ERK following B1 receptor ligand stimulation.	Poly I-C	48-56	bradykinin receptor B1	Homo sapiens	105-116
17881767-8	2007	Following treatment of the monolayers with poly (I:C), an innate immune activator that acts via TLR3, viral shedding was reduced significantly, comparable to levels seen when an antiviral formulation, acyclovir, was used.	Poly I-C	43-52	toll like receptor 3	Homo sapiens	96-100
17950621-5	2007	Japanese flounder MSH was observed to be highly expressed in immune-related tissues and are induced by immune stimulants, lipopolysaccharide (LPS), polyI:C and peptidoglycan (PG) in vitro suggesting that it is involved in fish immunity particularly against viral and bacterial agents, a functional feature exhibited by previously reported fish cytokines.	Poly I-C	148-155	proopiomelanocortin a	Danio rerio	18-21
17960767-4	2008	We report here on the effects of H2O2 (a canonical oxidant and non conventional messenger) and polyinosinic-polycytidylic acid (poly(IC) which elicits schizophrenia-like behaviors in newborn rodents and disrupts dopaminergic system development), on DRD2 levels in retinoic acid differentiated SH-SY5Y neuroblastoma.	Poly I-C	95-126	dopamine receptor D2	Homo sapiens	249-253
17962643-2	2007	Previous studies indicated that human NK cells express TLR3 and that, upon stimulation by polyinosinic-polycytidylic acid [poly (I:C)], they release cytokines and up-regulate cytotoxicity.	Poly I-C	90-121	toll like receptor 3	Homo sapiens	55-59
17962643-2	2007	Previous studies indicated that human NK cells express TLR3 and that, upon stimulation by polyinosinic-polycytidylic acid [poly (I:C)], they release cytokines and up-regulate cytotoxicity.	Poly I-C	123-133	toll like receptor 3	Homo sapiens	55-59
17962643-7	2007	Moreover, the increased cytolytic activity induced by treatment with poly (I:C) does not depend on increment of the expression of activating NK receptors and co-receptors, adhesion molecules or perforin/granzyme, but correlates with higher cell responsiveness to NKp46 ligation.	Poly I-C	69-79	natural cytotoxicity triggering receptor 1	Homo sapiens	263-268
17911629-5	2007	Polyinosinic-polycytidylic acid activated IFN regulatory factor 3 dimerization and phosphorylation, increased activity of the IFN-stimulated response element, induced a significant increase in IFN-beta mRNA transcripts and IFN-beta secretion, and up-regulated the expression of IFN-regulated genes in IECs.	Poly I-C	0-31	interferon alpha 1	Homo sapiens	42-45
17892510-3	2007	Cultures with uninfected dendritic cells known to elicit T helper 2 (Th2) responses and with polyinosinic-polycytidylic acid (poly-IC)-stimulated dendritic cells known to elicit Th1 responses served as controls.	Poly I-C	126-133	negative elongation factor complex member C/D	Homo sapiens	178-181
17684041-6	2007	Stimulation of macrophages with agonists for TLR3 {polyinosinic:polycytidylic acid [poly(I:C)]}, TLR4 (LPS), or TLR7/8 (R848) results in concurrent expression of EBI3 and p28.	Poly I-C	51-82	toll like receptor 3	Homo sapiens	45-49
17684041-6	2007	Stimulation of macrophages with agonists for TLR3 {polyinosinic:polycytidylic acid [poly(I:C)]}, TLR4 (LPS), or TLR7/8 (R848) results in concurrent expression of EBI3 and p28.	Poly I-C	51-82	Epstein-Barr virus induced 3	Homo sapiens	162-166
17877757-6	2007	The inhibitory effects of AICAR in poly (I:C)-mediated signalling for NF-kappaB activation and production of TNF-alpha were analysed in vitro.	Poly I-C	35-45	tumor necrosis factor	Mus musculus	109-118
17877757-8	2007	Interestingly, AICAR significantly attenuated poly (I:C)-induced airway hyperresponsiveness and airway inflammation, as shown by the attenuation of the influx of total inflammatory cells and soluble products into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL-5, IL-13, TNF-alpha and IFN-gamma.	Poly I-C	46-56	interleukin 5	Mus musculus	277-281
17877757-8	2007	Interestingly, AICAR significantly attenuated poly (I:C)-induced airway hyperresponsiveness and airway inflammation, as shown by the attenuation of the influx of total inflammatory cells and soluble products into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL-5, IL-13, TNF-alpha and IFN-gamma.	Poly I-C	46-56	interleukin 13	Mus musculus	283-288
17877757-8	2007	Interestingly, AICAR significantly attenuated poly (I:C)-induced airway hyperresponsiveness and airway inflammation, as shown by the attenuation of the influx of total inflammatory cells and soluble products into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL-5, IL-13, TNF-alpha and IFN-gamma.	Poly I-C	46-56	tumor necrosis factor	Mus musculus	290-299
17877757-8	2007	Interestingly, AICAR significantly attenuated poly (I:C)-induced airway hyperresponsiveness and airway inflammation, as shown by the attenuation of the influx of total inflammatory cells and soluble products into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL-5, IL-13, TNF-alpha and IFN-gamma.	Poly I-C	46-56	interferon gamma	Mus musculus	304-313
17877757-11	2007	Moreover, AICAR effectively inhibited poly (I:C)-mediated activation of NF-kappaB and the production of TNF-alpha.	Poly I-C	38-48	tumor necrosis factor	Mus musculus	104-113
17911629-5	2007	Polyinosinic-polycytidylic acid activated IFN regulatory factor 3 dimerization and phosphorylation, increased activity of the IFN-stimulated response element, induced a significant increase in IFN-beta mRNA transcripts and IFN-beta secretion, and up-regulated the expression of IFN-regulated genes in IECs.	Poly I-C	0-31	interferon alpha 1	Homo sapiens	126-129
17911629-5	2007	Polyinosinic-polycytidylic acid activated IFN regulatory factor 3 dimerization and phosphorylation, increased activity of the IFN-stimulated response element, induced a significant increase in IFN-beta mRNA transcripts and IFN-beta secretion, and up-regulated the expression of IFN-regulated genes in IECs.	Poly I-C	0-31	interferon beta 1	Homo sapiens	193-201
17911629-5	2007	Polyinosinic-polycytidylic acid activated IFN regulatory factor 3 dimerization and phosphorylation, increased activity of the IFN-stimulated response element, induced a significant increase in IFN-beta mRNA transcripts and IFN-beta secretion, and up-regulated the expression of IFN-regulated genes in IECs.	Poly I-C	0-31	interferon beta 1	Homo sapiens	223-231
17911629-5	2007	Polyinosinic-polycytidylic acid activated IFN regulatory factor 3 dimerization and phosphorylation, increased activity of the IFN-stimulated response element, induced a significant increase in IFN-beta mRNA transcripts and IFN-beta secretion, and up-regulated the expression of IFN-regulated genes in IECs.	Poly I-C	0-31	interferon alpha 1	Homo sapiens	126-129
17823983-4	2007	Infections that induce type I IFN production by cells other than pDC (a condition mimicked by poly(I:C) injection in vivo) increase the prevalence of Ly49Q(-) pDC in the bone marrow and peripheral lymphoid organs in wild-type but not IFN-alpha/beta receptor knockout BALB/c mice.	Poly I-C	94-103	interferon alpha 1	Homo sapiens	30-33
17823983-4	2007	Infections that induce type I IFN production by cells other than pDC (a condition mimicked by poly(I:C) injection in vivo) increase the prevalence of Ly49Q(-) pDC in the bone marrow and peripheral lymphoid organs in wild-type but not IFN-alpha/beta receptor knockout BALB/c mice.	Poly I-C	94-103	killer cell lectin-like receptor, subfamily A, member 17	Mus musculus	150-155
17823983-4	2007	Infections that induce type I IFN production by cells other than pDC (a condition mimicked by poly(I:C) injection in vivo) increase the prevalence of Ly49Q(-) pDC in the bone marrow and peripheral lymphoid organs in wild-type but not IFN-alpha/beta receptor knockout BALB/c mice.	Poly I-C	94-103	interferon alpha	Mus musculus	234-243
17786279-9	2007	Specific stimulation of NK cell TLR3 with its ligand polyinosinic-polycytidylic acid (Poly I:C) impairs the internalization of this Toll-like receptor and leads to activated NK cells within the HNSCC microenvironment.	Poly I-C	53-84	toll like receptor 3	Homo sapiens	32-36
17661372-4	2007	Stimulation with polyinosinic-polycytidylic acid [poly(I:C), a synthetic analog of viral dsRNA] induced the activation of transcription factors [nuclear factor (NF)-kappaB and interferon regulatory factor 3 (IRF3)] and the production of interferon-beta1 (IFN-beta1) and MxA as potent antiviral responses.	Poly I-C	17-48	interferon regulatory factor 3	Homo sapiens	176-206
17661372-4	2007	Stimulation with polyinosinic-polycytidylic acid [poly(I:C), a synthetic analog of viral dsRNA] induced the activation of transcription factors [nuclear factor (NF)-kappaB and interferon regulatory factor 3 (IRF3)] and the production of interferon-beta1 (IFN-beta1) and MxA as potent antiviral responses.	Poly I-C	17-48	interferon regulatory factor 3	Homo sapiens	208-212
17661372-4	2007	Stimulation with polyinosinic-polycytidylic acid [poly(I:C), a synthetic analog of viral dsRNA] induced the activation of transcription factors [nuclear factor (NF)-kappaB and interferon regulatory factor 3 (IRF3)] and the production of interferon-beta1 (IFN-beta1) and MxA as potent antiviral responses.	Poly I-C	17-48	interferon beta 1	Homo sapiens	237-253
17661372-4	2007	Stimulation with polyinosinic-polycytidylic acid [poly(I:C), a synthetic analog of viral dsRNA] induced the activation of transcription factors [nuclear factor (NF)-kappaB and interferon regulatory factor 3 (IRF3)] and the production of interferon-beta1 (IFN-beta1) and MxA as potent antiviral responses.	Poly I-C	17-48	interferon beta 1	Homo sapiens	255-264
17661372-4	2007	Stimulation with polyinosinic-polycytidylic acid [poly(I:C), a synthetic analog of viral dsRNA] induced the activation of transcription factors [nuclear factor (NF)-kappaB and interferon regulatory factor 3 (IRF3)] and the production of interferon-beta1 (IFN-beta1) and MxA as potent antiviral responses.	Poly I-C	17-48	MX dynamin like GTPase 1	Homo sapiens	270-273
17661372-4	2007	Stimulation with polyinosinic-polycytidylic acid [poly(I:C), a synthetic analog of viral dsRNA] induced the activation of transcription factors [nuclear factor (NF)-kappaB and interferon regulatory factor 3 (IRF3)] and the production of interferon-beta1 (IFN-beta1) and MxA as potent antiviral responses.	Poly I-C	50-58	interferon regulatory factor 3	Homo sapiens	176-206
17661372-4	2007	Stimulation with polyinosinic-polycytidylic acid [poly(I:C), a synthetic analog of viral dsRNA] induced the activation of transcription factors [nuclear factor (NF)-kappaB and interferon regulatory factor 3 (IRF3)] and the production of interferon-beta1 (IFN-beta1) and MxA as potent antiviral responses.	Poly I-C	50-58	interferon regulatory factor 3	Homo sapiens	208-212
17661372-4	2007	Stimulation with polyinosinic-polycytidylic acid [poly(I:C), a synthetic analog of viral dsRNA] induced the activation of transcription factors [nuclear factor (NF)-kappaB and interferon regulatory factor 3 (IRF3)] and the production of interferon-beta1 (IFN-beta1) and MxA as potent antiviral responses.	Poly I-C	50-58	interferon beta 1	Homo sapiens	237-253
17661372-4	2007	Stimulation with polyinosinic-polycytidylic acid [poly(I:C), a synthetic analog of viral dsRNA] induced the activation of transcription factors [nuclear factor (NF)-kappaB and interferon regulatory factor 3 (IRF3)] and the production of interferon-beta1 (IFN-beta1) and MxA as potent antiviral responses.	Poly I-C	50-58	interferon beta 1	Homo sapiens	255-264
17661372-4	2007	Stimulation with polyinosinic-polycytidylic acid [poly(I:C), a synthetic analog of viral dsRNA] induced the activation of transcription factors [nuclear factor (NF)-kappaB and interferon regulatory factor 3 (IRF3)] and the production of interferon-beta1 (IFN-beta1) and MxA as potent antiviral responses.	Poly I-C	50-58	MX dynamin like GTPase 1	Homo sapiens	270-273
17786279-9	2007	Specific stimulation of NK cell TLR3 with its ligand polyinosinic-polycytidylic acid (Poly I:C) impairs the internalization of this Toll-like receptor and leads to activated NK cells within the HNSCC microenvironment.	Poly I-C	86-94	toll like receptor 3	Homo sapiens	32-36
17878381-3	2007	Treatment of RAW 264.7 murine macrophage-like cells with the dsRNA analog polyinosinic:polycytidylic acid (poly-IC) promotes the release of free arachidonic acid that is subsequently converted into PGE2 by the de novo-synthesized cyclooxygenase-2 (COX-2) enzyme.	Poly I-C	107-114	prostaglandin-endoperoxide synthase 2	Mus musculus	230-246
17878381-3	2007	Treatment of RAW 264.7 murine macrophage-like cells with the dsRNA analog polyinosinic:polycytidylic acid (poly-IC) promotes the release of free arachidonic acid that is subsequently converted into PGE2 by the de novo-synthesized cyclooxygenase-2 (COX-2) enzyme.	Poly I-C	107-114	prostaglandin-endoperoxide synthase 2	Mus musculus	248-253
17878381-8	2007	Finally, cellular depletion of TLR3 by siRNA inhibits COX-2 expression, PGE2 generation, and iNOS induction by poly-IC.	Poly I-C	111-118	toll-like receptor 3	Mus musculus	31-35
17878381-8	2007	Finally, cellular depletion of TLR3 by siRNA inhibits COX-2 expression, PGE2 generation, and iNOS induction by poly-IC.	Poly I-C	111-118	nitric oxide synthase 2, inducible	Mus musculus	93-97
17963596-6	2007	The expressions of TLR3 were up-regulated significantly at 24 h and 48 h after stimulation with poly I:C in the HV group, and in the CH group they were not significantly increased at 24 h but obviously increased at 48 h. The mRNA expressions of TLR3 increased significantly at 12 h in the HV groups, and at 48 h in CH group.	Poly I-C	96-104	toll like receptor 3	Homo sapiens	19-23
17891146-5	2007	Viral infection or administration of poly(I:C), a ligand for TLR3, led to cytokine storm in T-cell- or lymphocyte-deficient mice in a fashion dependent on NK cells and tumor necrosis factor.	Poly I-C	37-45	toll-like receptor 3	Mus musculus	61-65
17963596-6	2007	The expressions of TLR3 were up-regulated significantly at 24 h and 48 h after stimulation with poly I:C in the HV group, and in the CH group they were not significantly increased at 24 h but obviously increased at 48 h. The mRNA expressions of TLR3 increased significantly at 12 h in the HV groups, and at 48 h in CH group.	Poly I-C	96-104	toll like receptor 3	Homo sapiens	245-249
17963596-7	2007	The rate of CD86 expressions increased after poly I:C stimulation, and the increased rates were 12.6%+/-9.8%, 23.8%+/-20.0%, 20.7%+/-14.3% in the CH group, and 31.0%+/-25.0%, 43.4%+/-24.7%, 44.6%+/-25.5% in the HV group at 12 h, 24 h and 48 h after poly I:C stimulation.	Poly I-C	45-53	CD86 molecule	Homo sapiens	12-16
17963596-7	2007	The rate of CD86 expressions increased after poly I:C stimulation, and the increased rates were 12.6%+/-9.8%, 23.8%+/-20.0%, 20.7%+/-14.3% in the CH group, and 31.0%+/-25.0%, 43.4%+/-24.7%, 44.6%+/-25.5% in the HV group at 12 h, 24 h and 48 h after poly I:C stimulation.	Poly I-C	249-257	CD86 molecule	Homo sapiens	12-16
17804388-3	2007	Poly(I:C) and loxoribine, in conjunction with IL-12, but not IL-15, triggered secretion of IFN-gamma.	Poly I-C	0-8	interferon gamma	Homo sapiens	91-100
17785847-7	2007	Alternatively, selective activation of TRIF by poly(I:C)-induced tolerance to lipid A.	Poly I-C	47-56	toll-like receptor adaptor molecule 2	Mus musculus	39-43
17804388-8	2007	Excitingly, IFN-gamma secretion was significantly increased when NK cells were stimulated with poly(I:C) or loxoribine and IL-12, and NKG2D engagement was induced by coculture with MICA+ tumor cells in a PI3K-dependent manner.	Poly I-C	95-104	interferon gamma	Homo sapiens	12-21
17855433-5	2007	Stimulation with tumor necrosis factor alpha, IL-1alpha, IFN-gamma, peptidoglycan and polyinosinic-polycytidylic acid [poly(I:C)] enhanced CXCL16 production.	Poly I-C	86-117	C-X-C motif chemokine ligand 16	Homo sapiens	139-145
17911421-0	2007	PolyI:C induction of diabetes is controlled by Iddm4 in rats with a full regulatory T cell pool.	Poly I-C	0-7	Insulin dependent diabetes mellitus QTL 8	Rattus norvegicus	47-52
17626075-4	2007	PIC induction of IDO was mediated in part by IFN-beta but not IFN-gamma, and both NF-kappaB and interferon regulatory factor 3 (IRF3) were required.	Poly I-C	0-3	indoleamine 2,3-dioxygenase 1	Homo sapiens	17-20
17892396-3	2007	We investigated the contribution of these kinases to IFN-beta expression in human macrophages treated with poly(I:C), lipopolysaccharide (LPS), Sendai virus, or vesicular stomatitis virus (VSV).	Poly I-C	107-115	interferon beta 1	Homo sapiens	53-61
17626075-4	2007	PIC induction of IDO was mediated in part by IFN-beta but not IFN-gamma, and both NF-kappaB and interferon regulatory factor 3 (IRF3) were required.	Poly I-C	0-3	interferon beta 1	Homo sapiens	45-53
17626075-7	2007	PIC caused suppression of intracellular replication of human immunodeficiency virus pseudotyped with vesicular stomatitis virus G protein and human cytomegalovirus in a manner dependent on IRF3 and IDO.	Poly I-C	0-3	interferon regulatory factor 3	Homo sapiens	189-193
17626075-7	2007	PIC caused suppression of intracellular replication of human immunodeficiency virus pseudotyped with vesicular stomatitis virus G protein and human cytomegalovirus in a manner dependent on IRF3 and IDO.	Poly I-C	0-3	indoleamine 2,3-dioxygenase 1	Homo sapiens	198-201
17303437-0	2007	Poly I:C inhibits the expression of channel catfish virus immediate-early gene ORF 1 at early times after infection.	Poly I-C	0-8	ORF1	Ictalurid herpesvirus 1	79-84
17897860-3	2007	Because TMEV may induce macrophages" cytokines through TLR3 and TLR7 (toll-like receptors), their role in TMEV-induced IL-23 and IFN-beta expression by the RAW264.7 macrophage cell line was determined following infection with TMEV or stimulation with the poly (I:C) or loxoribine.	Poly I-C	255-264	toll-like receptor 7	Mus musculus	64-68
17897860-4	2007	TMEV infection or stimulation with poly (I:C), a TLR3 agonist, or loxoribine, a TLR7 agonist, induced expression of IL-23 and IFN-beta in RAW264.7 cells.	Poly I-C	35-44	toll-like receptor 3	Mus musculus	49-53
17897860-4	2007	TMEV infection or stimulation with poly (I:C), a TLR3 agonist, or loxoribine, a TLR7 agonist, induced expression of IL-23 and IFN-beta in RAW264.7 cells.	Poly I-C	35-44	interleukin 23, alpha subunit p19	Mus musculus	116-121
17897860-4	2007	TMEV infection or stimulation with poly (I:C), a TLR3 agonist, or loxoribine, a TLR7 agonist, induced expression of IL-23 and IFN-beta in RAW264.7 cells.	Poly I-C	35-44	interferon beta 1, fibroblast	Mus musculus	126-134
17303437-4	2007	In this work we demonstrate that treatment of channel catfish ovary (CCO) cells, a fibroblast-like cell line, with poly I:C, a known inducer of Type I interferons, results in inhibition of expression of the CCV IE gene ORF 1.	Poly I-C	115-123	ORF1	Ictalurid herpesvirus 1	219-224
17525722-2	2007	Here, we sought to enhance the immunogenicity of leukemic cells by loading them with the double-stranded (ds) RNA Toll-like receptor 3 (TLR3) ligand polyriboinosinic polyribocytidylic acid (poly(I:C)), mimicking viral infection of the tumor cells.	Poly I-C	149-188	toll like receptor 3	Homo sapiens	114-134
17448568-0	2007	Liver-specific HBsAg transgenic mice are over-sensitive to Poly(I:C)-induced liver injury in NK cell- and IFN-gamma-dependent manner.	Poly I-C	59-68	interferon gamma	Mus musculus	106-115
17448568-5	2007	RESULTS: HBs-B6 mice were over-sensitive to Poly(I:C)-induced liver injury, which was absolutely dependent on the presence of NK cells and IFN-gamma produced by intrahepatic NK cells.	Poly I-C	44-53	interferon gamma	Mus musculus	139-148
17448568-6	2007	Much stronger IFN-gamma receptor expression was observed on hepatocytes of HBs-B6 mice, which was significantly enhanced by Poly(I:C) injection.	Poly I-C	124-133	interferon gamma	Mus musculus	14-23
17525722-2	2007	Here, we sought to enhance the immunogenicity of leukemic cells by loading them with the double-stranded (ds) RNA Toll-like receptor 3 (TLR3) ligand polyriboinosinic polyribocytidylic acid (poly(I:C)), mimicking viral infection of the tumor cells.	Poly I-C	149-188	toll like receptor 3	Homo sapiens	136-140
17525722-4	2007	Primary acute myeloid leukemia (AML) cells and AML cell lines markedly responded to poly(I:C) electroporation by apoptosis, upregulation of TLR3 expression, enhanced expression of major histocompatibility complex (MHC) and costimulatory molecules and by production of type I interferons (IFN).	Poly I-C	84-92	toll like receptor 3	Homo sapiens	140-144
17525722-4	2007	Primary acute myeloid leukemia (AML) cells and AML cell lines markedly responded to poly(I:C) electroporation by apoptosis, upregulation of TLR3 expression, enhanced expression of major histocompatibility complex (MHC) and costimulatory molecules and by production of type I interferons (IFN).	Poly I-C	84-92	interferon alpha 1	Homo sapiens	268-292
17332440-8	2007	However, ds poly I-C (TLR3 ligand), LPS (TLR4 ligand), ssRNA (TLR8 ligand), and CpG-DNA (TLR9 ligand) were much less effective or inactive.	Poly I-C	12-20	toll like receptor 3	Homo sapiens	22-26
17463084-3	2007	The present work reports that TLR3 signaling by polyinosinic-polycytidylic acid stimulation induces intestinal epithelial cells (IECs) to express retinoic acid early inducible-1 (a ligand for NKG2D) and to induce NKG2D expression on CD8alphaalpha intestinal intraepithelial lymphocytes by IL-15 derived from TLR3-activated IECs.	Poly I-C	48-79	toll-like receptor 3	Mus musculus	30-34
17395700-6	2007	In accordance to these data, Poly(I:C) suppressed TSH-induced 125I uptake and hormone synthesis dose dependently, accompanied by a decrease in the ratio of 125I-T3/125I-T4 released into the culture medium, whereas peptidoglycan, lipopolysaccharides, or unmethylated CpG DNA, ligands for TLR2, TLR4, and TLR9, respectively, had no significant effect.	Poly I-C	29-37	toll like receptor 2	Homo sapiens	287-291
17395700-6	2007	In accordance to these data, Poly(I:C) suppressed TSH-induced 125I uptake and hormone synthesis dose dependently, accompanied by a decrease in the ratio of 125I-T3/125I-T4 released into the culture medium, whereas peptidoglycan, lipopolysaccharides, or unmethylated CpG DNA, ligands for TLR2, TLR4, and TLR9, respectively, had no significant effect.	Poly I-C	29-37	toll like receptor 4	Homo sapiens	293-297
17395700-6	2007	In accordance to these data, Poly(I:C) suppressed TSH-induced 125I uptake and hormone synthesis dose dependently, accompanied by a decrease in the ratio of 125I-T3/125I-T4 released into the culture medium, whereas peptidoglycan, lipopolysaccharides, or unmethylated CpG DNA, ligands for TLR2, TLR4, and TLR9, respectively, had no significant effect.	Poly I-C	29-37	toll like receptor 9	Homo sapiens	303-307
17548618-5	2007	Systemic application of the synthetic TLR-3 or TLR-7 ligands polycytidylic-polyinosinic acid (p(I:C)) or R-848, respectively, during the sensitization phase prevented the production of OVA-specific IgE and IgG1 Abs and subsequently abolished all features of experimental asthma including airway hyperresponsiveness and allergic airway inflammation.	Poly I-C	61-92	toll-like receptor 3	Mus musculus	38-43
17548618-5	2007	Systemic application of the synthetic TLR-3 or TLR-7 ligands polycytidylic-polyinosinic acid (p(I:C)) or R-848, respectively, during the sensitization phase prevented the production of OVA-specific IgE and IgG1 Abs and subsequently abolished all features of experimental asthma including airway hyperresponsiveness and allergic airway inflammation.	Poly I-C	61-92	toll-like receptor 7	Mus musculus	47-52
17548618-5	2007	Systemic application of the synthetic TLR-3 or TLR-7 ligands polycytidylic-polyinosinic acid (p(I:C)) or R-848, respectively, during the sensitization phase prevented the production of OVA-specific IgE and IgG1 Abs and subsequently abolished all features of experimental asthma including airway hyperresponsiveness and allergic airway inflammation.	Poly I-C	61-92	LOC105243590	Mus musculus	206-210
17267173-3	2007	In naive mice, poly I:C (2mg/kg) modestly increased sickness behaviors, plasma IL-6, TNF-alpha and IL-10 levels, but did not affect IL-1, IL-4, or IFN-gamma.	Poly I-C	15-23	interleukin 6	Mus musculus	79-83
17267173-3	2007	In naive mice, poly I:C (2mg/kg) modestly increased sickness behaviors, plasma IL-6, TNF-alpha and IL-10 levels, but did not affect IL-1, IL-4, or IFN-gamma.	Poly I-C	15-23	tumor necrosis factor	Mus musculus	85-94
17267173-3	2007	In naive mice, poly I:C (2mg/kg) modestly increased sickness behaviors, plasma IL-6, TNF-alpha and IL-10 levels, but did not affect IL-1, IL-4, or IFN-gamma.	Poly I-C	15-23	interleukin 10	Mus musculus	99-104
17267173-3	2007	In naive mice, poly I:C (2mg/kg) modestly increased sickness behaviors, plasma IL-6, TNF-alpha and IL-10 levels, but did not affect IL-1, IL-4, or IFN-gamma.	Poly I-C	15-23	interleukin 1 complex	Mus musculus	99-103
17348024-6	2007	Stimulation with polyinosinic-polycytidylic acid, a synthetic dsRNA analogue, induced the expression of inducible nitric oxide synthase (iNOS) gene in Schwann cells.	Poly I-C	17-48	nitric oxide synthase 2	Rattus norvegicus	104-135
17348024-6	2007	Stimulation with polyinosinic-polycytidylic acid, a synthetic dsRNA analogue, induced the expression of inducible nitric oxide synthase (iNOS) gene in Schwann cells.	Poly I-C	17-48	nitric oxide synthase 2	Rattus norvegicus	137-141
17386406-2	2007	injected with polyinosinic-polycytidylic acid (poly I:C), the specific TLR3 agonist, at a dose of 10 microg/g BW or PBS at gestation day (gd) 6.5.	Poly I-C	14-45	toll-like receptor 3	Mus musculus	71-75
17386406-2	2007	injected with polyinosinic-polycytidylic acid (poly I:C), the specific TLR3 agonist, at a dose of 10 microg/g BW or PBS at gestation day (gd) 6.5.	Poly I-C	47-55	toll-like receptor 3	Mus musculus	71-75
17386406-3	2007	The CD69 expression of uNK (DX5(+)CD3(-)) cells was highly up-regulated and reached 92.3+/-0.9%, the percentage of intracellular TNF-alpha(+) or IFN-gamma(+) uNK (DX5(+)CD3(-)) cells in the implantation sites of CBAxDBA/2 matings was also significantly increased 24 h after poly I:C injection.	Poly I-C	274-282	CD69 molecule	Homo sapiens	4-8
17463084-4	2007	The blockade of interaction between NKG2D and Rae1 inhibits the cytotoxicity of intraepithelial lymphocytes against IECs in a cell-cell contact-dependent manner and therefore alleviates polyinosinic-polycytidylic acid-induced epithelial destruction and acute mucosal injury of small intestine.	Poly I-C	186-217	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	36-41
17463084-4	2007	The blockade of interaction between NKG2D and Rae1 inhibits the cytotoxicity of intraepithelial lymphocytes against IECs in a cell-cell contact-dependent manner and therefore alleviates polyinosinic-polycytidylic acid-induced epithelial destruction and acute mucosal injury of small intestine.	Poly I-C	186-217	ribonucleic acid export 1	Mus musculus	46-50
17449641-2	2007	We previously reported that polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA (dsRNA), induces the expression of galectin-9 in human umbilical vein endothelial cells (HUVECs).	Poly I-C	28-59	galectin 9	Homo sapiens	139-149
17393379-9	2007	Protection against colitis given by poly(I:C) treatment was ablated in TLR3 KO, indicating that the protective action of this viral RNA analog was mediated by this receptor.	Poly I-C	36-45	toll-like receptor 3	Mus musculus	71-75
17196665-7	2007	Meanwhile, 24h after poly I:C injection, expression of TLR3 was markedly elevated within decidua basalis (DB), and endometrial TNF-alpha increased 2.7-fold but IFN-gamma remained unchanged in homogenized endometrium.	Poly I-C	21-29	toll-like receptor 3	Mus musculus	55-59
17196665-7	2007	Meanwhile, 24h after poly I:C injection, expression of TLR3 was markedly elevated within decidua basalis (DB), and endometrial TNF-alpha increased 2.7-fold but IFN-gamma remained unchanged in homogenized endometrium.	Poly I-C	21-29	tumor necrosis factor	Mus musculus	127-136
17196665-7	2007	Meanwhile, 24h after poly I:C injection, expression of TLR3 was markedly elevated within decidua basalis (DB), and endometrial TNF-alpha increased 2.7-fold but IFN-gamma remained unchanged in homogenized endometrium.	Poly I-C	21-29	interferon gamma	Mus musculus	160-169
17475874-3	2007	We generated Lgp2-deficient mice and report that the loss of this gene greatly sensitizes cells to cytosolic polyinosinic/polycytidylic acid-mediated induction of type I IFN.	Poly I-C	109-140	DEXH (Asp-Glu-X-His) box polypeptide 58	Mus musculus	13-17
17475879-0	2007	The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid.	Poly I-C	139-170	high mobility group box 1	Mus musculus	39-68
17475879-3	2007	In in vitro studies, proinflammatory molecules such as LPS, lipoteichoic acid, polyinosinic-polycytidylic acid (poly(I:C)), TNF-alpha, and type I and II IFNs can induce HMGB1 release from macrophages.	Poly I-C	79-110	high mobility group box 1	Mus musculus	169-174
17072335-5	2007	Analysis of the innate immune response in the DNA-PKcs-deficient mice with short dysfunctional telomeres revealed high basal serum levels of tumor necrosis factor alpha (TNFalpha) and hyper-active cytokine responses upon challenge with polyinosinic-polycytidylic acid (poly-IC).	Poly I-C	236-267	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	46-54
17072335-5	2007	Analysis of the innate immune response in the DNA-PKcs-deficient mice with short dysfunctional telomeres revealed high basal serum levels of tumor necrosis factor alpha (TNFalpha) and hyper-active cytokine responses upon challenge with polyinosinic-polycytidylic acid (poly-IC).	Poly I-C	236-267	tumor necrosis factor	Mus musculus	141-168
17072335-5	2007	Analysis of the innate immune response in the DNA-PKcs-deficient mice with short dysfunctional telomeres revealed high basal serum levels of tumor necrosis factor alpha (TNFalpha) and hyper-active cytokine responses upon challenge with polyinosinic-polycytidylic acid (poly-IC).	Poly I-C	269-276	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	46-54
17157033-8	2007	Poly IC-induced RTS11 aggregation was blocked by two inhibitors of dsRNA-dependent protein kinase (PKR).	Poly I-C	0-7	interferon-induced, double-stranded RNA-activated protein kinase	Oncorhynchus mykiss	99-102
17463084-3	2007	The present work reports that TLR3 signaling by polyinosinic-polycytidylic acid stimulation induces intestinal epithelial cells (IECs) to express retinoic acid early inducible-1 (a ligand for NKG2D) and to induce NKG2D expression on CD8alphaalpha intestinal intraepithelial lymphocytes by IL-15 derived from TLR3-activated IECs.	Poly I-C	48-79	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	192-197
17463084-3	2007	The present work reports that TLR3 signaling by polyinosinic-polycytidylic acid stimulation induces intestinal epithelial cells (IECs) to express retinoic acid early inducible-1 (a ligand for NKG2D) and to induce NKG2D expression on CD8alphaalpha intestinal intraepithelial lymphocytes by IL-15 derived from TLR3-activated IECs.	Poly I-C	48-79	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	213-218
17463084-3	2007	The present work reports that TLR3 signaling by polyinosinic-polycytidylic acid stimulation induces intestinal epithelial cells (IECs) to express retinoic acid early inducible-1 (a ligand for NKG2D) and to induce NKG2D expression on CD8alphaalpha intestinal intraepithelial lymphocytes by IL-15 derived from TLR3-activated IECs.	Poly I-C	48-79	interleukin 15	Mus musculus	289-294
17463084-3	2007	The present work reports that TLR3 signaling by polyinosinic-polycytidylic acid stimulation induces intestinal epithelial cells (IECs) to express retinoic acid early inducible-1 (a ligand for NKG2D) and to induce NKG2D expression on CD8alphaalpha intestinal intraepithelial lymphocytes by IL-15 derived from TLR3-activated IECs.	Poly I-C	48-79	toll-like receptor 3	Mus musculus	308-312
17376830-1	2007	Iddm4 is a dominant non-major histocompatibility complex (MHC) determinant of diabetes susceptibility in BBDR rats treated with poly I:C, plus depletion of regulatory T cells.	Poly I-C	128-136	Insulin dependent diabetes mellitus QTL 8	Rattus norvegicus	0-5
17347473-4	2007	We demonstrate that lipopolysaccharide, a TLR4 ligand; and polyinosinic:polycytidylic acid (poly I:C), a TLR3 ligand; but not lipoteichoic acid, a TLR2 ligand, upregulate macrophage EL expression both ex vivo and in vivo.	Poly I-C	59-90	toll-like receptor 3	Mus musculus	105-109
17347473-4	2007	We demonstrate that lipopolysaccharide, a TLR4 ligand; and polyinosinic:polycytidylic acid (poly I:C), a TLR3 ligand; but not lipoteichoic acid, a TLR2 ligand, upregulate macrophage EL expression both ex vivo and in vivo.	Poly I-C	59-90	lipase, endothelial	Mus musculus	182-184
17347473-4	2007	We demonstrate that lipopolysaccharide, a TLR4 ligand; and polyinosinic:polycytidylic acid (poly I:C), a TLR3 ligand; but not lipoteichoic acid, a TLR2 ligand, upregulate macrophage EL expression both ex vivo and in vivo.	Poly I-C	92-100	toll-like receptor 3	Mus musculus	105-109
17347473-4	2007	We demonstrate that lipopolysaccharide, a TLR4 ligand; and polyinosinic:polycytidylic acid (poly I:C), a TLR3 ligand; but not lipoteichoic acid, a TLR2 ligand, upregulate macrophage EL expression both ex vivo and in vivo.	Poly I-C	92-100	toll-like receptor 2	Mus musculus	147-151
17347473-5	2007	In contrast, macrophage lipoprotein lipase expression is significantly repressed by lipopolysaccharide or poly I:C.	Poly I-C	106-114	lipoprotein lipase	Mus musculus	24-42
17347473-6	2007	Using C3HJ and TLR3 knockout mice, we further show that upregulation of macrophage EL expression by lipopolysaccharide or poly I:C is TLR4 or TLR3 dependent, respectively.	Poly I-C	122-130	toll-like receptor 3	Mus musculus	15-19
17347473-6	2007	Using C3HJ and TLR3 knockout mice, we further show that upregulation of macrophage EL expression by lipopolysaccharide or poly I:C is TLR4 or TLR3 dependent, respectively.	Poly I-C	122-130	lipase, endothelial	Mus musculus	83-85
17347473-6	2007	Using C3HJ and TLR3 knockout mice, we further show that upregulation of macrophage EL expression by lipopolysaccharide or poly I:C is TLR4 or TLR3 dependent, respectively.	Poly I-C	122-130	toll-like receptor 4	Mus musculus	134-138
17347473-6	2007	Using C3HJ and TLR3 knockout mice, we further show that upregulation of macrophage EL expression by lipopolysaccharide or poly I:C is TLR4 or TLR3 dependent, respectively.	Poly I-C	122-130	toll-like receptor 3	Mus musculus	142-146
17341432-5	2007	However, rats immunized with MBP(68-86) plus CpG-ODN and PolyI:C, a TLR3 agonist, did not develop EAE.	Poly I-C	57-64	toll-like receptor 3	Rattus norvegicus	68-72
17253645-6	2007	As seen with LPS, other toll-like receptor agonists (polyinosinic-polycytidylic acid, peptidoglycan from Staphylococcus aureus, and the oligonucleotide CpG1668) also down-regulate C/EBPalpha whereas cytokines such as interleukin-1beta, interleukin-6, macrophage-colony stimulating factor, and interferon-gamma do not.	Poly I-C	53-84	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	180-190
17328045-10	2007	Poly(I-C), lipopolysaccharide, and tumor necrosis factor alpha (TNFalpha) activated phosphorylation of IKKepsilon and IRF-3 in FLS.	Poly I-C	0-9	inhibitor of kappaB kinase epsilon	Mus musculus	103-113
17209042-10	2007	We examined the recombinant TLR3 ECD for disulfide bond formation, poly(I:C) binding, and protein-protein interaction.	Poly I-C	67-76	toll like receptor 3	Homo sapiens	28-32
17328045-10	2007	Poly(I-C), lipopolysaccharide, and tumor necrosis factor alpha (TNFalpha) activated phosphorylation of IKKepsilon and IRF-3 in FLS.	Poly I-C	0-9	interferon regulatory factor 3	Mus musculus	118-123
17471165-0	2007	CD4+ T helper cell response is required for memory in CD8+ T lymphocytes induced by a poly(I:C)-adjuvanted MHC I-restricted peptide epitope.	Poly I-C	86-95	CD4 antigen	Mus musculus	0-3
17277125-2	2007	Polyriboinosine-polyribocytidylic acid sodium salt (poly(IC)) is a mimic of dsRNA and viral infection that activates TLR3 and the RNA helicases retinoic acid-induced gene-1 and melanoma differentiation-associated gene-5, and strongly induces type I IFN production.	Poly I-C	52-60	toll like receptor 3	Homo sapiens	117-121
17277125-2	2007	Polyriboinosine-polyribocytidylic acid sodium salt (poly(IC)) is a mimic of dsRNA and viral infection that activates TLR3 and the RNA helicases retinoic acid-induced gene-1 and melanoma differentiation-associated gene-5, and strongly induces type I IFN production.	Poly I-C	52-60	interferon induced with helicase C domain 1	Homo sapiens	130-219
17156928-9	2007	The intracisternal administration of an anti-TGF-beta antibody partially inhibited fever induced by poly I:C administration; however, this treatment did not affect the decrease in SMA.	Poly I-C	100-108	transforming growth factor, beta 1	Rattus norvegicus	45-53
17156928-11	2007	These results indicate that TGF-beta in the brain, which was increased by poly I:C administration, is associated with fever but not with a decrease in SMA.	Poly I-C	74-82	transforming growth factor, beta 1	Rattus norvegicus	28-36
17258730-10	2007	Ethanol reduced expression of CD40 and CD86 costimulatory molecules on resting DCs, which was corrected following stimulation with lipopolysaccharide or poly I:C.	Poly I-C	153-161	CD40 molecule	Homo sapiens	30-34
17258730-10	2007	Ethanol reduced expression of CD40 and CD86 costimulatory molecules on resting DCs, which was corrected following stimulation with lipopolysaccharide or poly I:C.	Poly I-C	153-161	CD86 molecule	Homo sapiens	39-43
17043099-4	2007	RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs.	Poly I-C	9-48	toll like receptor 3	Homo sapiens	96-100
17043099-4	2007	RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs.	Poly I-C	9-48	interleukin 6	Homo sapiens	130-134
17043099-4	2007	RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs.	Poly I-C	9-48	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
17043099-4	2007	RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs.	Poly I-C	9-48	C-X-C motif chemokine ligand 6	Homo sapiens	145-150
17043099-4	2007	RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs.	Poly I-C	50-58	toll like receptor 3	Homo sapiens	96-100
17043099-4	2007	RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs.	Poly I-C	50-58	interleukin 6	Homo sapiens	130-134
17043099-4	2007	RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs.	Poly I-C	50-58	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
17043099-4	2007	RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs.	Poly I-C	50-58	C-X-C motif chemokine ligand 6	Homo sapiens	145-150
17043099-5	2007	Poly I:C-induced production of these cytokines by OECs was inhibited by the pretreatment of these cells with anti-TLR3 antibody.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	114-118
17043099-6	2007	The phosphorylation of IkappaB-alpha protein was detected in OECs after stimulation by poly I:C.	Poly I-C	87-95	NFKB inhibitor alpha	Homo sapiens	23-36
17316136-4	2007	We found that polyI:C, LPS, R848, S-28463, and ODN2006, which are specifically recognized by TLR3, TLR4, TLR7/8, and TLR9 in mammals, induced substantial amounts of type I interferon (IFN) and interleukin-6 (IL-6) in freshly prepared chicken splenocytes.	Poly I-C	14-21	toll like receptor 3	Gallus gallus	93-97
17316136-4	2007	We found that polyI:C, LPS, R848, S-28463, and ODN2006, which are specifically recognized by TLR3, TLR4, TLR7/8, and TLR9 in mammals, induced substantial amounts of type I interferon (IFN) and interleukin-6 (IL-6) in freshly prepared chicken splenocytes.	Poly I-C	14-21	toll like receptor 4	Gallus gallus	99-103
17316136-4	2007	We found that polyI:C, LPS, R848, S-28463, and ODN2006, which are specifically recognized by TLR3, TLR4, TLR7/8, and TLR9 in mammals, induced substantial amounts of type I interferon (IFN) and interleukin-6 (IL-6) in freshly prepared chicken splenocytes.	Poly I-C	14-21	toll like receptor 7	Gallus gallus	105-109
17316136-4	2007	We found that polyI:C, LPS, R848, S-28463, and ODN2006, which are specifically recognized by TLR3, TLR4, TLR7/8, and TLR9 in mammals, induced substantial amounts of type I interferon (IFN) and interleukin-6 (IL-6) in freshly prepared chicken splenocytes.	Poly I-C	14-21	interleukin 6	Gallus gallus	193-206
17316136-4	2007	We found that polyI:C, LPS, R848, S-28463, and ODN2006, which are specifically recognized by TLR3, TLR4, TLR7/8, and TLR9 in mammals, induced substantial amounts of type I interferon (IFN) and interleukin-6 (IL-6) in freshly prepared chicken splenocytes.	Poly I-C	14-21	interleukin 6	Gallus gallus	208-212
17316136-7	2007	However, human 293 cells expressing ChTLR3 strongly and specifically responded to polyI:C, demonstrating that this chicken receptor represents a true ortholog of mammalian TLR3.	Poly I-C	82-89	toll like receptor 3	Homo sapiens	38-42
17202379-7	2007	Surprisingly, the TLR9 ligand CpG oligodeoxynucleotide 2006 was able to specifically inhibit poly(I:C)-induced IL-8 and IDO expression.	Poly I-C	93-102	toll like receptor 9	Homo sapiens	18-22
17202379-7	2007	Surprisingly, the TLR9 ligand CpG oligodeoxynucleotide 2006 was able to specifically inhibit poly(I:C)-induced IL-8 and IDO expression.	Poly I-C	93-102	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
17202379-7	2007	Surprisingly, the TLR9 ligand CpG oligodeoxynucleotide 2006 was able to specifically inhibit poly(I:C)-induced IL-8 and IDO expression.	Poly I-C	93-102	indoleamine 2,3-dioxygenase 1	Homo sapiens	120-123
17190817-8	2007	The lack of TICAM-1 did not affect IFN production but resulted in unresponsiveness to IL-12 production, mDC maturation, and polyI:C-mediated NK-antitumor activity.	Poly I-C	124-131	toll-like receptor adaptor molecule 1	Mus musculus	12-19
17177965-8	2007	In vitro studies evaluating the cell source of these cytokines revealed that polyriboinosinic polyribocytidylic acid (poly I:C) activated retinal vascular endothelial cells produce sE-selectin, sICAM-1 and IFN-beta.	Poly I-C	77-116	interferon beta 1	Homo sapiens	206-214
17163447-5	2007	Specifically, we show that mice of MOLF/Ei, Czech/Ei, and MSM/Ms strains are hypo-responsive to polyinosinic-polycytidylic acid (poly(I:C)) because of a mutation in Tlr3.	Poly I-C	96-127	toll-like receptor 3	Mus musculus	165-169
17171759-5	2007	IL-2 stimulation leads to an up-regulation of SAP expression, which can be enhanced by IL-12, the stimulation of TLR3 by polyinosinic-polycytidylic acid (poly(I:C))and to a lesser extent by IFN-alpha.	Poly I-C	121-152	interleukin 2	Homo sapiens	0-4
17171759-5	2007	IL-2 stimulation leads to an up-regulation of SAP expression, which can be enhanced by IL-12, the stimulation of TLR3 by polyinosinic-polycytidylic acid (poly(I:C))and to a lesser extent by IFN-alpha.	Poly I-C	121-152	SH2 domain containing 1A	Homo sapiens	46-49
17171759-5	2007	IL-2 stimulation leads to an up-regulation of SAP expression, which can be enhanced by IL-12, the stimulation of TLR3 by polyinosinic-polycytidylic acid (poly(I:C))and to a lesser extent by IFN-alpha.	Poly I-C	121-152	toll like receptor 3	Homo sapiens	113-117
17541283-10	2007	CONCLUSIONS: Synthetic dsRNA poly I:C stimulates the expression of inflammatory chemokines in airway epithelial cells, but the putative receptors for dsRNA such as RIG-I, MDA-5, or PKR may not play pivotal roles in this process.	Poly I-C	29-37	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	181-184
18084696-5	2007	Thus, LPS and poly-IC can upregulate TSLP via a NF-kappaB pathway in synovial fibroblasts, which is downregulated by dexamethasone and interferon (IFN)-gamma.	Poly I-C	14-21	thymic stromal lymphopoietin	Homo sapiens	37-41
17182588-6	2007	We have determined by confocal laser-scanning microscopy that the immunoreactivity of TLR3 was aggregated intracellularly in poly(I:C)-stimulated BSMC, colocalizing with fluorescein-labeled poly(I:C).	Poly I-C	125-134	toll like receptor 3	Homo sapiens	86-90
17182588-6	2007	We have determined by confocal laser-scanning microscopy that the immunoreactivity of TLR3 was aggregated intracellularly in poly(I:C)-stimulated BSMC, colocalizing with fluorescein-labeled poly(I:C).	Poly I-C	125-133	toll like receptor 3	Homo sapiens	86-90
17182588-3	2007	Synthetic dsRNA, polyinosinic-cystidic acid (poly(I:C)), induced the synthesis of eosinophilic chemokines, eotaxin-1/CCL11 and RANTES/CCL5, from primary cultures of human BSMC, and IL-4 increased synergistically the synthesis of poly(I:C)-induced CCL11.	Poly I-C	45-54	C-C motif chemokine ligand 11	Homo sapiens	107-116
17182588-3	2007	Synthetic dsRNA, polyinosinic-cystidic acid (poly(I:C)), induced the synthesis of eosinophilic chemokines, eotaxin-1/CCL11 and RANTES/CCL5, from primary cultures of human BSMC, and IL-4 increased synergistically the synthesis of poly(I:C)-induced CCL11.	Poly I-C	45-54	C-C motif chemokine ligand 11	Homo sapiens	117-122
17182588-3	2007	Synthetic dsRNA, polyinosinic-cystidic acid (poly(I:C)), induced the synthesis of eosinophilic chemokines, eotaxin-1/CCL11 and RANTES/CCL5, from primary cultures of human BSMC, and IL-4 increased synergistically the synthesis of poly(I:C)-induced CCL11.	Poly I-C	45-54	C-C motif chemokine ligand 5	Homo sapiens	127-133
17182588-3	2007	Synthetic dsRNA, polyinosinic-cystidic acid (poly(I:C)), induced the synthesis of eosinophilic chemokines, eotaxin-1/CCL11 and RANTES/CCL5, from primary cultures of human BSMC, and IL-4 increased synergistically the synthesis of poly(I:C)-induced CCL11.	Poly I-C	45-54	C-C motif chemokine ligand 5	Homo sapiens	134-138
17182588-3	2007	Synthetic dsRNA, polyinosinic-cystidic acid (poly(I:C)), induced the synthesis of eosinophilic chemokines, eotaxin-1/CCL11 and RANTES/CCL5, from primary cultures of human BSMC, and IL-4 increased synergistically the synthesis of poly(I:C)-induced CCL11.	Poly I-C	45-54	interleukin 4	Homo sapiens	181-185
17182588-3	2007	Synthetic dsRNA, polyinosinic-cystidic acid (poly(I:C)), induced the synthesis of eosinophilic chemokines, eotaxin-1/CCL11 and RANTES/CCL5, from primary cultures of human BSMC, and IL-4 increased synergistically the synthesis of poly(I:C)-induced CCL11.	Poly I-C	45-54	C-C motif chemokine ligand 11	Homo sapiens	247-252
17182588-3	2007	Synthetic dsRNA, polyinosinic-cystidic acid (poly(I:C)), induced the synthesis of eosinophilic chemokines, eotaxin-1/CCL11 and RANTES/CCL5, from primary cultures of human BSMC, and IL-4 increased synergistically the synthesis of poly(I:C)-induced CCL11.	Poly I-C	229-238	C-C motif chemokine ligand 11	Homo sapiens	107-116
18084696-5	2007	Thus, LPS and poly-IC can upregulate TSLP via a NF-kappaB pathway in synovial fibroblasts, which is downregulated by dexamethasone and interferon (IFN)-gamma.	Poly I-C	14-21	interferon gamma	Homo sapiens	135-157
17198265-8	2006	The adoptive transfer of NK cells, including a TRAIL-expressing fraction, extracted from the liver perfusates of poly I:C-stimulated B6 mice inhibited the growth of liver metastasis in B6 or (B6xBALB/c) F1 (B6CF1) mice that underwent hepatectomy and received intraportal Hepa1-6 injection.	Poly I-C	113-121	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	47-52
17133483-7	2006	Induction of NK cell killing of activated HSCs by poly I:C was attenuated in STAT1-/- mice compared to wild-type mice, which was likely due to reduced NKG2D and TRAIL expression on STAT1-/- NK cells.	Poly I-C	50-58	signal transducer and activator of transcription 1	Mus musculus	77-82
17142740-10	2006	Phosphorylated PKR was detected in PMphi, but not AMphi, after poly(I:C) treatment.	Poly I-C	63-72	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	15-18
17008311-6	2006	Finally, cryopyrin was required for IL-1beta production in response to poly(I:C) in vivo.	Poly I-C	71-79	NLR family pyrin domain containing 3	Homo sapiens	9-18
17008311-6	2006	Finally, cryopyrin was required for IL-1beta production in response to poly(I:C) in vivo.	Poly I-C	71-79	interleukin 1 beta	Homo sapiens	36-44
17157040-6	2006	SHP-2 inhibited poly(I:C)-induced cytokine production by a phosphatase activity-independent mechanism.	Poly I-C	16-25	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	0-5
17133483-7	2006	Induction of NK cell killing of activated HSCs by poly I:C was attenuated in STAT1-/- mice compared to wild-type mice, which was likely due to reduced NKG2D and TRAIL expression on STAT1-/- NK cells.	Poly I-C	50-58	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	161-166
17114417-4	2006	We report in this study that TLR3 stimulation by polyinosinic-polycytidylic acid, a double-stranded RNA analog, suppresses relapsing demyelination in a murine experimental autoimmune encephalomyelitis model.	Poly I-C	49-80	toll-like receptor 3	Mus musculus	29-33
16904755-7	2006	Moreover, the cells significantly increased their expression of IL-18 and IFN-gamma when stimulated with polyinosinic-polycytidylic acid (Poly (I:C)).	Poly I-C	105-136	interleukin 18	Canis lupus familiaris	64-69
17238832-3	2006	IL-10 induction was TLR ligand selective, in that CpG DNA, imidazoquinolin, peptidoglycan, and zymosan but not lipopolysaccharide (LPS) and poly I:C led to IL-10 production.	Poly I-C	140-148	interleukin 10	Mus musculus	0-5
17045750-4	2006	The PolyI:C treatment did not induce morphological abnormalities but resulted in a significant increase in GABAA receptor subunit alpha2 immunoreactivity (IR) in the ventral dentate gyrus and basolateral amygdala in adult treated compared to control subjects.	Poly I-C	4-11	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	107-112
16904755-7	2006	Moreover, the cells significantly increased their expression of IL-18 and IFN-gamma when stimulated with polyinosinic-polycytidylic acid (Poly (I:C)).	Poly I-C	105-136	interferon gamma	Canis lupus familiaris	74-83
16904755-7	2006	Moreover, the cells significantly increased their expression of IL-18 and IFN-gamma when stimulated with polyinosinic-polycytidylic acid (Poly (I:C)).	Poly I-C	138-148	interleukin 18	Canis lupus familiaris	64-69
16904755-7	2006	Moreover, the cells significantly increased their expression of IL-18 and IFN-gamma when stimulated with polyinosinic-polycytidylic acid (Poly (I:C)).	Poly I-C	138-148	interferon gamma	Canis lupus familiaris	74-83
17046999-6	2006	On the surface of poly-I:C-stimulated vascular smooth muscle cells, versican organizes into fibrillar structures that contain elastin but are largely distinct from those formed by hyaluronan.	Poly I-C	18-26	elastin	Homo sapiens	126-133
17063122-6	2006	After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs.	Poly I-C	22-53	CD40 molecule	Homo sapiens	129-133
17063122-6	2006	After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs.	Poly I-C	22-53	CD80 molecule	Homo sapiens	135-139
17063122-6	2006	After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs.	Poly I-C	22-53	CD83 molecule	Homo sapiens	145-149
17063122-6	2006	After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs.	Poly I-C	22-53	tumor necrosis factor	Homo sapiens	181-208
17063122-6	2006	After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs.	Poly I-C	22-53	interleukin 1 beta	Homo sapiens	210-232
17063122-6	2006	After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs.	Poly I-C	22-53	interleukin 6	Homo sapiens	234-238
17063122-6	2006	After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs.	Poly I-C	22-53	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
16900204-0	2006	Genetic susceptibility to polyI:C-induced IFNalpha/beta-dependent accelerated disease in lupus-prone mice.	Poly I-C	26-33	interferon beta 1, fibroblast	Mus musculus	42-55
16935934-6	2006	Activation of ASMC by poly(I:C) induced a specific cytokine repertoire characterized by induction of CXCL10 generation and the potential to recruit mast cells.	Poly I-C	22-31	C-X-C motif chemokine ligand 10	Homo sapiens	101-107
16900204-4	2006	We generated a model of accelerated proteinuria, in which lupus-prone mice were injected repeatedly with polyinosinic:polycytidylic acid (polyI:C), mimicking exposure to virus-derived double stranded RNA (dsRNA), leading to the production of IFNalpha/beta.	Poly I-C	105-136	interferon beta 1, fibroblast	Mus musculus	242-255
16900204-5	2006	PolyI:C-treated (B6.Nba2 x NZW)F1 and (B6 x NZW)F1 hybrid mice developed significantly increased levels of anti-dsDNA autoantibodies, characteristic of lupus.	Poly I-C	0-7	New Zealand Black autoimmunity 2	Mus musculus	20-24
16900204-6	2006	Most significantly, polyI:C-treated (B6.Nba2 x NZW)F1 mice, but not (B6 x NZW)F1 or parental strains, developed lupus-like nephritis in an accelerated fashion, which was dependent on IFNalpha/beta and associated with elevated deposition of total IgG, IgG2a and complement factor C3 in the glomerular capillary walls.	Poly I-C	20-27	New Zealand Black autoimmunity 2	Mus musculus	40-44
16900204-6	2006	Most significantly, polyI:C-treated (B6.Nba2 x NZW)F1 mice, but not (B6 x NZW)F1 or parental strains, developed lupus-like nephritis in an accelerated fashion, which was dependent on IFNalpha/beta and associated with elevated deposition of total IgG, IgG2a and complement factor C3 in the glomerular capillary walls.	Poly I-C	20-27	interferon alpha	Mus musculus	183-191
16900204-6	2006	Most significantly, polyI:C-treated (B6.Nba2 x NZW)F1 mice, but not (B6 x NZW)F1 or parental strains, developed lupus-like nephritis in an accelerated fashion, which was dependent on IFNalpha/beta and associated with elevated deposition of total IgG, IgG2a and complement factor C3 in the glomerular capillary walls.	Poly I-C	20-27	immunoglobulin heavy variable V1-9	Mus musculus	251-281
16911361-11	2006	The study of siRNA for NF-kappaB and IRF3 showed that they transduce the signal of poly I : C, but their roles were different in each target gene.	Poly I-C	83-93	nuclear factor kappa B subunit 1	Homo sapiens	23-32
17006930-4	2006	Results show that disruption of the STAT1 gene abolished poly I:C suppression of liver regeneration and the inhibitory effect of poly I:C on liver regeneration was diminished in IRF-1(-/-) and p21(cip1-/-)mice.	Poly I-C	57-65	signal transducer and activator of transcription 1	Mus musculus	36-41
17006930-4	2006	Results show that disruption of the STAT1 gene abolished poly I:C suppression of liver regeneration and the inhibitory effect of poly I:C on liver regeneration was diminished in IRF-1(-/-) and p21(cip1-/-)mice.	Poly I-C	129-137	interferon regulatory factor 1	Mus musculus	178-183
17006930-4	2006	Results show that disruption of the STAT1 gene abolished poly I:C suppression of liver regeneration and the inhibitory effect of poly I:C on liver regeneration was diminished in IRF-1(-/-) and p21(cip1-/-)mice.	Poly I-C	129-137	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	193-196
17006930-4	2006	Results show that disruption of the STAT1 gene abolished poly I:C suppression of liver regeneration and the inhibitory effect of poly I:C on liver regeneration was diminished in IRF-1(-/-) and p21(cip1-/-)mice.	Poly I-C	129-137	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	197-201
17006930-7	2006	Hepatocyte proliferation was unaffected by treatment with poly I:C alone, but when hepatocytes were co-cultured with liver lymphocytes, proliferation was inhibited by IFN-gamma/STAT1-dependent mechanisms.	Poly I-C	58-66	interferon gamma	Mus musculus	167-176
17006930-7	2006	Hepatocyte proliferation was unaffected by treatment with poly I:C alone, but when hepatocytes were co-cultured with liver lymphocytes, proliferation was inhibited by IFN-gamma/STAT1-dependent mechanisms.	Poly I-C	58-66	signal transducer and activator of transcription 1	Mus musculus	177-182
16849320-5	2006	LPS and poly(I-C) induce very high levels of Viperin in wild type cells but not in cells deficient in TRIF, TBK1, IRF3, or the type I IFNalpha/betaR.	Poly I-C	8-16	radical S-adenosyl methionine domain containing 2	Homo sapiens	45-52
16930225-5	2006	Treatment with poly I:C also induced expression of NKG2D, granzyme B, perforin, Fas L, TRAIL, and IFN-gamma on liver lymphocytes, which were delayed or reduced in ethanol-treated mice compared with pair-fed mice.	Poly I-C	15-23	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	51-56
16930225-5	2006	Treatment with poly I:C also induced expression of NKG2D, granzyme B, perforin, Fas L, TRAIL, and IFN-gamma on liver lymphocytes, which were delayed or reduced in ethanol-treated mice compared with pair-fed mice.	Poly I-C	15-23	granzyme B	Mus musculus	58-68
16930225-5	2006	Treatment with poly I:C also induced expression of NKG2D, granzyme B, perforin, Fas L, TRAIL, and IFN-gamma on liver lymphocytes, which were delayed or reduced in ethanol-treated mice compared with pair-fed mice.	Poly I-C	15-23	Fas ligand (TNF superfamily, member 6)	Mus musculus	80-85
16930225-5	2006	Treatment with poly I:C also induced expression of NKG2D, granzyme B, perforin, Fas L, TRAIL, and IFN-gamma on liver lymphocytes, which were delayed or reduced in ethanol-treated mice compared with pair-fed mice.	Poly I-C	15-23	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	87-92
16930225-5	2006	Treatment with poly I:C also induced expression of NKG2D, granzyme B, perforin, Fas L, TRAIL, and IFN-gamma on liver lymphocytes, which were delayed or reduced in ethanol-treated mice compared with pair-fed mice.	Poly I-C	15-23	interferon gamma	Mus musculus	98-107
16751646-4	2006	Therefore, trophoblast cells were exposed to the TLR-3 agonist, Poly(I : C).	Poly I-C	64-75	toll like receptor 3	Homo sapiens	49-54
16920974-0	2006	The role of IFN-alpha and nitric oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic-polycytidylic acid or lipopolysaccharide.	Poly I-C	98-129	high mobility group box 1	Mus musculus	57-62
16982913-2	2006	To explore the spectrum of genes induced in human astrocytes by TLR3, we used a microarray approach and the analog polyriboinosinic polyribocytidylic acid (pIC) as ligand.	Poly I-C	115-154	toll like receptor 3	Homo sapiens	64-68
16966508-6	2006	RESULTS: Serum samples positive for NAbs significantly inhibited polyinosinic-polycytidylic acid-induced CXCL10 and IL-6 production by astrocytes.	Poly I-C	65-96	C-X-C motif chemokine ligand 10	Homo sapiens	105-111
16966508-6	2006	RESULTS: Serum samples positive for NAbs significantly inhibited polyinosinic-polycytidylic acid-induced CXCL10 and IL-6 production by astrocytes.	Poly I-C	65-96	interleukin 6	Homo sapiens	116-120
16911361-11	2006	The study of siRNA for NF-kappaB and IRF3 showed that they transduce the signal of poly I : C, but their roles were different in each target gene.	Poly I-C	83-93	interferon regulatory factor 3	Homo sapiens	37-41
16810634-4	2006	Anti-snRNP B cells proliferated vigorously and secreted abundant anti-snRNP autoAb upon exposure to CpG or polyriboinosinic polyribocytidylic acid [poly (I:C)] in vitro.	Poly I-C	107-146	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Mus musculus	5-10
16810634-4	2006	Anti-snRNP B cells proliferated vigorously and secreted abundant anti-snRNP autoAb upon exposure to CpG or polyriboinosinic polyribocytidylic acid [poly (I:C)] in vitro.	Poly I-C	107-146	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Mus musculus	70-75
16554548-2	2006	RNA samples were collected at 3 and 24 h after PBMCs were challenged with the Toll-like receptor-3 (TLR3) agonist polyinosinic acid-polycytidylic acid [poly(I:C)] and analyzed by internally developed cDNA microarrays and TaqMan PCR.	Poly I-C	114-150	toll like receptor 3	Homo sapiens	78-98
16554548-2	2006	RNA samples were collected at 3 and 24 h after PBMCs were challenged with the Toll-like receptor-3 (TLR3) agonist polyinosinic acid-polycytidylic acid [poly(I:C)] and analyzed by internally developed cDNA microarrays and TaqMan PCR.	Poly I-C	114-150	toll like receptor 3	Homo sapiens	100-104
16704888-1	2006	Poly (I:C), a TLR3 ligand, has shown promise as a vaccine adjuvant to CD8(+) T cell responses.	Poly I-C	0-9	toll like receptor 3	Homo sapiens	14-18
16728430-3	2006	Tracking cytokine production in PBMC initially revealed that a subset of TLR agonists including polyinosinic-polycytidylic acid (poly I:C), 3M-002, 3M-003, R-848 and single-stranded RNA trigger relatively high levels of IFN-gamma expression by NK cells.	Poly I-C	96-127	interferon gamma	Homo sapiens	220-229
16728431-3	2006	The TLR3 ligand poly(I)poly(C) triggered up-regulation of its own receptor in NOR and pre-diabetic NOD, but TLR3 was already highly expressed in diabetic NOD mice.	Poly I-C	16-30	toll-like receptor 3	Mus musculus	4-8
16728431-4	2006	Expression levels of TLR3 correlated with poly(I)poly(C)-triggered IFN activity.	Poly I-C	42-56	toll-like receptor 3	Mus musculus	21-25
16511519-5	2006	Higher numbers of Melan-A/MART-1-specific CTLs were consistently obtained with poly(I:C(12)U)-activated DCs compared to DCs matured in the presence of an inflammatory cytokine cocktail.	Poly I-C	79-87	melan-A	Homo sapiens	18-25
16511519-5	2006	Higher numbers of Melan-A/MART-1-specific CTLs were consistently obtained with poly(I:C(12)U)-activated DCs compared to DCs matured in the presence of an inflammatory cytokine cocktail.	Poly I-C	79-87	melan-A	Homo sapiens	26-32
16628196-4	2006	Treatment with polyinosinic-polycytidylic acid (poly(I:C)) resulted in the rapid translocation of IFN regulatory factor (IRF)-3 into the nucleus, followed by phosphorylation of STAT1 and STAT3.	Poly I-C	15-46	interferon regulatory factor 3	Homo sapiens	98-127
16628196-4	2006	Treatment with polyinosinic-polycytidylic acid (poly(I:C)) resulted in the rapid translocation of IFN regulatory factor (IRF)-3 into the nucleus, followed by phosphorylation of STAT1 and STAT3.	Poly I-C	15-46	signal transducer and activator of transcription 1	Homo sapiens	177-182
16628196-4	2006	Treatment with polyinosinic-polycytidylic acid (poly(I:C)) resulted in the rapid translocation of IFN regulatory factor (IRF)-3 into the nucleus, followed by phosphorylation of STAT1 and STAT3.	Poly I-C	15-46	signal transducer and activator of transcription 3	Homo sapiens	187-192
16628196-4	2006	Treatment with polyinosinic-polycytidylic acid (poly(I:C)) resulted in the rapid translocation of IFN regulatory factor (IRF)-3 into the nucleus, followed by phosphorylation of STAT1 and STAT3.	Poly I-C	48-57	interferon regulatory factor 3	Homo sapiens	98-127
16628196-4	2006	Treatment with polyinosinic-polycytidylic acid (poly(I:C)) resulted in the rapid translocation of IFN regulatory factor (IRF)-3 into the nucleus, followed by phosphorylation of STAT1 and STAT3.	Poly I-C	48-57	signal transducer and activator of transcription 1	Homo sapiens	177-182
16628196-4	2006	Treatment with polyinosinic-polycytidylic acid (poly(I:C)) resulted in the rapid translocation of IFN regulatory factor (IRF)-3 into the nucleus, followed by phosphorylation of STAT1 and STAT3.	Poly I-C	48-57	signal transducer and activator of transcription 3	Homo sapiens	187-192
16628196-5	2006	The activation of STATs by poly(I:C) probably occurs in an indirect fashion, through poly(I:C)-induced IFN.	Poly I-C	27-35	signal transducer and activator of transcription 1	Homo sapiens	18-23
16628196-5	2006	The activation of STATs by poly(I:C) probably occurs in an indirect fashion, through poly(I:C)-induced IFN.	Poly I-C	27-36	signal transducer and activator of transcription 1	Homo sapiens	18-23
16628196-9	2006	SOCS1 infection inhibited the phosphorylation of STAT1 and significantly reduced poly(I:C)-induced MIP-1alpha production.	Poly I-C	81-90	suppressor of cytokine signaling 1	Homo sapiens	0-5
16628196-9	2006	SOCS1 infection inhibited the phosphorylation of STAT1 and significantly reduced poly(I:C)-induced MIP-1alpha production.	Poly I-C	81-90	C-C motif chemokine ligand 3	Homo sapiens	99-109
16704888-1	2006	Poly (I:C), a TLR3 ligand, has shown promise as a vaccine adjuvant to CD8(+) T cell responses.	Poly I-C	0-9	CD8a molecule	Homo sapiens	70-73
16704888-8	2006	Further, the adjuvant effects of poly (I:C) were dependent on the endogenous levels of type I IFNs, TNF-alpha, IFN-gamma, IL-12, and IL-15.	Poly I-C	33-43	tumor necrosis factor	Homo sapiens	100-109
16704888-8	2006	Further, the adjuvant effects of poly (I:C) were dependent on the endogenous levels of type I IFNs, TNF-alpha, IFN-gamma, IL-12, and IL-15.	Poly I-C	33-43	interferon gamma	Homo sapiens	111-120
16704888-8	2006	Further, the adjuvant effects of poly (I:C) were dependent on the endogenous levels of type I IFNs, TNF-alpha, IFN-gamma, IL-12, and IL-15.	Poly I-C	33-43	interleukin 15	Homo sapiens	133-138
16704888-10	2006	We conclude that the adjuvant effects of poly (I:C) on antigen-specific CD8(+) T cells appeared to be exquisitely dependent on the rapid induction of certain beneficial cytokines produced in part by NK cells.	Poly I-C	41-51	CD8a molecule	Homo sapiens	72-75
16399790-6	2006	Additionally, preexposure to DE(as) significantly increased the poly(I:C)-induced expression of IL-6.	Poly I-C	64-73	interleukin 6	Homo sapiens	96-100
16670308-8	2006	Anti-CD40 also increased polyinosinic-polycytidylic acid (poly(I:C))-inducible IFN-alpha by 5-fold in an IFN-gamma-dependent fashion, but did not significantly increase IFN-alpha production to CpG or Pam(3)Cys challenges.	Poly I-C	25-56	CD40 antigen	Mus musculus	5-9
16674601-7	2006	Incubation of polarized epithelial cells with TLR agonists [lipopolysaccharide (LPS), Pam3Cys, Poly (I:C) or PGN] induced TLR5 and TLR9 expression but had no effect on TLR4, defensins or SLPI.	Poly I-C	95-105	toll-like receptor 5	Mus musculus	122-126
16674601-7	2006	Incubation of polarized epithelial cells with TLR agonists [lipopolysaccharide (LPS), Pam3Cys, Poly (I:C) or PGN] induced TLR5 and TLR9 expression but had no effect on TLR4, defensins or SLPI.	Poly I-C	95-105	toll-like receptor 9	Mus musculus	131-135
16714379-2	2006	Both RIG-I and mda-5 can bind polyriboinosinic:polyribocytidylic acid (polyI:C), the synthetic analog of viral dsRNA, and mediate type I IFN responses to polyI:C and multiple RNA viruses in vitro.	Poly I-C	71-78	DEAD/H box helicase 58	Mus musculus	5-10
16714379-2	2006	Both RIG-I and mda-5 can bind polyriboinosinic:polyribocytidylic acid (polyI:C), the synthetic analog of viral dsRNA, and mediate type I IFN responses to polyI:C and multiple RNA viruses in vitro.	Poly I-C	71-78	interferon induced with helicase C domain 1	Mus musculus	15-20
16714379-3	2006	We generated mda-5-deficient mice and showed that mda-5 is the dominant receptor mediating type I IFN secretion in response to polyI:C in vitro and in vivo.	Poly I-C	127-134	interferon induced with helicase C domain 1	Mus musculus	13-18
16674601-8	2006	Furthermore, exposure to LPS, Pam3Cys, Poly (I:C) or PGN, induced MCP-1 secretion by polarized epithelial cells in culture.	Poly I-C	39-49	chemokine (C-C motif) ligand 2	Mus musculus	66-71
16714379-3	2006	We generated mda-5-deficient mice and showed that mda-5 is the dominant receptor mediating type I IFN secretion in response to polyI:C in vitro and in vivo.	Poly I-C	127-134	interferon induced with helicase C domain 1	Mus musculus	50-55
16670308-8	2006	Anti-CD40 also increased polyinosinic-polycytidylic acid (poly(I:C))-inducible IFN-alpha by 5-fold in an IFN-gamma-dependent fashion, but did not significantly increase IFN-alpha production to CpG or Pam(3)Cys challenges.	Poly I-C	25-56	interferon alpha	Mus musculus	79-88
16670308-8	2006	Anti-CD40 also increased polyinosinic-polycytidylic acid (poly(I:C))-inducible IFN-alpha by 5-fold in an IFN-gamma-dependent fashion, but did not significantly increase IFN-alpha production to CpG or Pam(3)Cys challenges.	Poly I-C	25-56	interferon gamma	Mus musculus	105-114
16670308-8	2006	Anti-CD40 also increased polyinosinic-polycytidylic acid (poly(I:C))-inducible IFN-alpha by 5-fold in an IFN-gamma-dependent fashion, but did not significantly increase IFN-alpha production to CpG or Pam(3)Cys challenges.	Poly I-C	58-67	CD40 antigen	Mus musculus	5-9
16670308-8	2006	Anti-CD40 also increased polyinosinic-polycytidylic acid (poly(I:C))-inducible IFN-alpha by 5-fold in an IFN-gamma-dependent fashion, but did not significantly increase IFN-alpha production to CpG or Pam(3)Cys challenges.	Poly I-C	58-67	interferon alpha	Mus musculus	79-88
16670308-8	2006	Anti-CD40 also increased polyinosinic-polycytidylic acid (poly(I:C))-inducible IFN-alpha by 5-fold in an IFN-gamma-dependent fashion, but did not significantly increase IFN-alpha production to CpG or Pam(3)Cys challenges.	Poly I-C	58-67	interferon gamma	Mus musculus	105-114
16670308-9	2006	Poly(IC)-stimulated splenocytes from anti-CD40-pretreated mice produced 4-fold more IFN-alpha than controls and production associated with CD11c(+) cells.	Poly I-C	0-8	CD40 antigen	Mus musculus	42-46
16670308-9	2006	Poly(IC)-stimulated splenocytes from anti-CD40-pretreated mice produced 4-fold more IFN-alpha than controls and production associated with CD11c(+) cells.	Poly I-C	0-8	interferon alpha	Mus musculus	84-93
16670308-9	2006	Poly(IC)-stimulated splenocytes from anti-CD40-pretreated mice produced 4-fold more IFN-alpha than controls and production associated with CD11c(+) cells.	Poly I-C	0-8	integrin subunit alpha X	Homo sapiens	139-144
16831928-10	2006	To demonstrate this, we injected wild-type C57B/6 and TNF-Tg mice with poly I:C, which is known to induce systemic IFN responses, and show its dominant effects on increasing the number of circulating CD11b+/CD11c+ precursor dendritic cells (pDC), concomitant with a dramatic reduction in CD11b+/CD11c- OCP.	Poly I-C	71-79	tumor necrosis factor	Mus musculus	54-57
16406095-8	2006	Moreover, histamine enhanced poly (I:C)-induced IL-8 secretion and phosphorylation of NF-kappaB in the two cell types, and histamine H1 receptor antagonists inhibited the action of histamine.	Poly I-C	29-39	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
16406095-10	2006	Histamine also enhanced poly (I:C) induced IL-8 secretion and phosphorylation of NF-kappaB.	Poly I-C	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
16831928-10	2006	To demonstrate this, we injected wild-type C57B/6 and TNF-Tg mice with poly I:C, which is known to induce systemic IFN responses, and show its dominant effects on increasing the number of circulating CD11b+/CD11c+ precursor dendritic cells (pDC), concomitant with a dramatic reduction in CD11b+/CD11c- OCP.	Poly I-C	71-79	interferon alpha 1	Homo sapiens	115-118
16831928-10	2006	To demonstrate this, we injected wild-type C57B/6 and TNF-Tg mice with poly I:C, which is known to induce systemic IFN responses, and show its dominant effects on increasing the number of circulating CD11b+/CD11c+ precursor dendritic cells (pDC), concomitant with a dramatic reduction in CD11b+/CD11c- OCP.	Poly I-C	71-79	integrin subunit alpha M	Homo sapiens	200-205
16831928-10	2006	To demonstrate this, we injected wild-type C57B/6 and TNF-Tg mice with poly I:C, which is known to induce systemic IFN responses, and show its dominant effects on increasing the number of circulating CD11b+/CD11c+ precursor dendritic cells (pDC), concomitant with a dramatic reduction in CD11b+/CD11c- OCP.	Poly I-C	71-79	integrin subunit alpha X	Homo sapiens	207-212
16831928-10	2006	To demonstrate this, we injected wild-type C57B/6 and TNF-Tg mice with poly I:C, which is known to induce systemic IFN responses, and show its dominant effects on increasing the number of circulating CD11b+/CD11c+ precursor dendritic cells (pDC), concomitant with a dramatic reduction in CD11b+/CD11c- OCP.	Poly I-C	71-79	integrin subunit alpha M	Homo sapiens	288-293
16831928-10	2006	To demonstrate this, we injected wild-type C57B/6 and TNF-Tg mice with poly I:C, which is known to induce systemic IFN responses, and show its dominant effects on increasing the number of circulating CD11b+/CD11c+ precursor dendritic cells (pDC), concomitant with a dramatic reduction in CD11b+/CD11c- OCP.	Poly I-C	71-79	integrin subunit alpha X	Homo sapiens	295-300
16585964-6	2006	Nrf2-deficient mouse embryonic fibroblasts showed greater activation of NF-kappaB and interferon regulatory factor 3 in response to LPS and polyinosinic-polycytidylic acid [poly(I:C)] stimulus, corroborating the effect of Nrf2 on MyD88-dependent and -independent signaling.	Poly I-C	140-171	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
16585964-6	2006	Nrf2-deficient mouse embryonic fibroblasts showed greater activation of NF-kappaB and interferon regulatory factor 3 in response to LPS and polyinosinic-polycytidylic acid [poly(I:C)] stimulus, corroborating the effect of Nrf2 on MyD88-dependent and -independent signaling.	Poly I-C	140-171	nuclear factor, erythroid derived 2, like 2	Mus musculus	222-226
16616084-0	2006	Potential role of toll-like receptor 3 in a murine model of polyinosinic-polycytidylic acid-induced embryo resorption.	Poly I-C	60-91	toll-like receptor 3	Mus musculus	18-38
16616084-1	2006	OBJECTIVE: To investigate the potential role that toll-like receptor 3 (TLR3) may play in a murine model of polyinosinic-polycytidylic acid (polyIC)-induced embryo resorption.	Poly I-C	108-139	toll-like receptor 3	Mus musculus	50-70
16616084-1	2006	OBJECTIVE: To investigate the potential role that toll-like receptor 3 (TLR3) may play in a murine model of polyinosinic-polycytidylic acid (polyIC)-induced embryo resorption.	Poly I-C	108-139	toll-like receptor 3	Mus musculus	72-76
16616084-1	2006	OBJECTIVE: To investigate the potential role that toll-like receptor 3 (TLR3) may play in a murine model of polyinosinic-polycytidylic acid (polyIC)-induced embryo resorption.	Poly I-C	141-148	toll-like receptor 3	Mus musculus	50-70
16616084-1	2006	OBJECTIVE: To investigate the potential role that toll-like receptor 3 (TLR3) may play in a murine model of polyinosinic-polycytidylic acid (polyIC)-induced embryo resorption.	Poly I-C	141-148	toll-like receptor 3	Mus musculus	72-76
16585964-6	2006	Nrf2-deficient mouse embryonic fibroblasts showed greater activation of NF-kappaB and interferon regulatory factor 3 in response to LPS and polyinosinic-polycytidylic acid [poly(I:C)] stimulus, corroborating the effect of Nrf2 on MyD88-dependent and -independent signaling.	Poly I-C	140-171	myeloid differentiation primary response gene 88	Mus musculus	230-235
16585964-6	2006	Nrf2-deficient mouse embryonic fibroblasts showed greater activation of NF-kappaB and interferon regulatory factor 3 in response to LPS and polyinosinic-polycytidylic acid [poly(I:C)] stimulus, corroborating the effect of Nrf2 on MyD88-dependent and -independent signaling.	Poly I-C	173-182	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
16585964-6	2006	Nrf2-deficient mouse embryonic fibroblasts showed greater activation of NF-kappaB and interferon regulatory factor 3 in response to LPS and polyinosinic-polycytidylic acid [poly(I:C)] stimulus, corroborating the effect of Nrf2 on MyD88-dependent and -independent signaling.	Poly I-C	140-171	interferon regulatory factor 3	Mus musculus	86-116
16585964-6	2006	Nrf2-deficient mouse embryonic fibroblasts showed greater activation of NF-kappaB and interferon regulatory factor 3 in response to LPS and polyinosinic-polycytidylic acid [poly(I:C)] stimulus, corroborating the effect of Nrf2 on MyD88-dependent and -independent signaling.	Poly I-C	173-182	interferon regulatory factor 3	Mus musculus	86-116
16280166-7	2006	Activation of huMC through TLR3 with increasing amounts of polyI:C inhibited mast cell adhesion in a dose-dependent manner.	Poly I-C	59-66	toll like receptor 3	Homo sapiens	27-31
16169598-11	2006	These results indicate that poly I:C transfection could improve IFN-like production in these cell lines.	Poly I-C	28-36	interferon alpha 1	Homo sapiens	64-67
16623926-5	2006	The synthetic dsRNA analogue polyinosinic acid : polycytidylic acid [Poly(I : C)] could only stimulate IFN-alpha production in enriched mDC but not in pDC.	Poly I-C	69-80	interferon alpha 1	Homo sapiens	103-112
16623926-5	2006	The synthetic dsRNA analogue polyinosinic acid : polycytidylic acid [Poly(I : C)] could only stimulate IFN-alpha production in enriched mDC but not in pDC.	Poly I-C	69-80	chemokine (C-C motif) ligand 22	Mus musculus	136-139
16424161-1	2006	TLR3 recognizes viral dsRNA and its synthetic mimetic polyinosinic-polycytidylic acid (poly(I:C)).	Poly I-C	54-85	toll like receptor 3	Homo sapiens	0-4
16310275-2	2006	Here we examined the effect of the activation of NK cells induced by toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly I:C), on concanavalin A (Con A)-induced T cell-mediated liver injury.	Poly I-C	105-136	toll-like receptor 3	Mus musculus	69-89
16310275-2	2006	Here we examined the effect of the activation of NK cells induced by toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly I:C), on concanavalin A (Con A)-induced T cell-mediated liver injury.	Poly I-C	105-136	toll-like receptor 3	Mus musculus	91-95
16265667-4	2006	Our results show that the injection of polyinosinic-polycytidylic acid (poly(I:C)), a synthetic dsRNA, into the striatum of the mouse brain induces the activation of astrocytes and the expression of TNF-alpha, IFN-beta, and IP-10.	Poly I-C	39-70	tumor necrosis factor	Mus musculus	199-208
16265667-4	2006	Our results show that the injection of polyinosinic-polycytidylic acid (poly(I:C)), a synthetic dsRNA, into the striatum of the mouse brain induces the activation of astrocytes and the expression of TNF-alpha, IFN-beta, and IP-10.	Poly I-C	39-70	interferon beta 1, fibroblast	Mus musculus	210-218
16265667-4	2006	Our results show that the injection of polyinosinic-polycytidylic acid (poly(I:C)), a synthetic dsRNA, into the striatum of the mouse brain induces the activation of astrocytes and the expression of TNF-alpha, IFN-beta, and IP-10.	Poly I-C	39-70	chemokine (C-X-C motif) ligand 10	Mus musculus	224-229
16265667-4	2006	Our results show that the injection of polyinosinic-polycytidylic acid (poly(I:C)), a synthetic dsRNA, into the striatum of the mouse brain induces the activation of astrocytes and the expression of TNF-alpha, IFN-beta, and IP-10.	Poly I-C	72-81	tumor necrosis factor	Mus musculus	199-208
16265667-4	2006	Our results show that the injection of polyinosinic-polycytidylic acid (poly(I:C)), a synthetic dsRNA, into the striatum of the mouse brain induces the activation of astrocytes and the expression of TNF-alpha, IFN-beta, and IP-10.	Poly I-C	72-81	interferon beta 1, fibroblast	Mus musculus	210-218
16265667-4	2006	Our results show that the injection of polyinosinic-polycytidylic acid (poly(I:C)), a synthetic dsRNA, into the striatum of the mouse brain induces the activation of astrocytes and the expression of TNF-alpha, IFN-beta, and IP-10.	Poly I-C	72-81	chemokine (C-X-C motif) ligand 10	Mus musculus	224-229
16265667-6	2006	Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-kappaB (NF-kappaB), JNK, ERK, glycogen synthase kinase-3beta (GSK-3beta), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction.	Poly I-C	77-86	mitogen-activated protein kinase 1	Homo sapiens	131-168
16265667-6	2006	Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-kappaB (NF-kappaB), JNK, ERK, glycogen synthase kinase-3beta (GSK-3beta), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction.	Poly I-C	77-86	mitogen-activated protein kinase 1	Homo sapiens	170-173
16265667-6	2006	Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-kappaB (NF-kappaB), JNK, ERK, glycogen synthase kinase-3beta (GSK-3beta), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction.	Poly I-C	77-86	mitogen-activated protein kinase 8	Homo sapiens	180-203
16265667-6	2006	Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-kappaB (NF-kappaB), JNK, ERK, glycogen synthase kinase-3beta (GSK-3beta), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction.	Poly I-C	77-86	mitogen-activated protein kinase 8	Homo sapiens	205-208
16265667-6	2006	Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-kappaB (NF-kappaB), JNK, ERK, glycogen synthase kinase-3beta (GSK-3beta), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction.	Poly I-C	77-86	mitogen-activated protein kinase 8	Homo sapiens	286-289
16265667-6	2006	Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-kappaB (NF-kappaB), JNK, ERK, glycogen synthase kinase-3beta (GSK-3beta), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction.	Poly I-C	77-86	mitogen-activated protein kinase 1	Homo sapiens	291-294
16265667-6	2006	Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-kappaB (NF-kappaB), JNK, ERK, glycogen synthase kinase-3beta (GSK-3beta), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction.	Poly I-C	77-86	glycogen synthase kinase 3 beta	Homo sapiens	296-326
16265667-6	2006	Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-kappaB (NF-kappaB), JNK, ERK, glycogen synthase kinase-3beta (GSK-3beta), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction.	Poly I-C	77-86	glycogen synthase kinase 3 beta	Homo sapiens	328-337
16265667-6	2006	Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-kappaB (NF-kappaB), JNK, ERK, glycogen synthase kinase-3beta (GSK-3beta), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction.	Poly I-C	77-86	C-X-C motif chemokine ligand 8	Homo sapiens	407-411
16265667-6	2006	Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-kappaB (NF-kappaB), JNK, ERK, glycogen synthase kinase-3beta (GSK-3beta), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction.	Poly I-C	77-86	C-X-C motif chemokine ligand 10	Homo sapiens	416-421
16265667-6	2006	Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-kappaB (NF-kappaB), JNK, ERK, glycogen synthase kinase-3beta (GSK-3beta), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction.	Poly I-C	77-86	toll like receptor 3	Homo sapiens	517-521
16517751-5	2006	In vitro, murine wild-type primary cultured microglia responded to synthetic dsRNA polyinosinic-polycytidylic acid (poly(I:C)) by increasing TLR3 and IFN-beta mRNA and by morphologic activation.	Poly I-C	83-114	toll-like receptor 3	Mus musculus	141-145
16517751-5	2006	In vitro, murine wild-type primary cultured microglia responded to synthetic dsRNA polyinosinic-polycytidylic acid (poly(I:C)) by increasing TLR3 and IFN-beta mRNA and by morphologic activation.	Poly I-C	83-114	interferon beta 1, fibroblast	Mus musculus	150-158
16517751-5	2006	In vitro, murine wild-type primary cultured microglia responded to synthetic dsRNA polyinosinic-polycytidylic acid (poly(I:C)) by increasing TLR3 and IFN-beta mRNA and by morphologic activation.	Poly I-C	116-125	toll-like receptor 3	Mus musculus	141-145
16517751-5	2006	In vitro, murine wild-type primary cultured microglia responded to synthetic dsRNA polyinosinic-polycytidylic acid (poly(I:C)) by increasing TLR3 and IFN-beta mRNA and by morphologic activation.	Poly I-C	116-125	interferon beta 1, fibroblast	Mus musculus	150-158
16517751-6	2006	Furthermore, wild-type microglia dose dependently secreted TNF-alpha and IL-6 after poly(I:C) challenge, whereas TLR3(-/-) microglia produced diminished cytokines.	Poly I-C	84-93	interleukin 6	Mus musculus	73-77
16310275-5	2006	RESULTS: Poly I:C pretreatment protected against T cell-mediated hepatitis, as evidenced by decreased mortality, hepatic necrosis, serum transaminase levels and inflammatory cytokines (IL-4, IFN-gamma).	Poly I-C	9-17	interleukin 4	Mus musculus	185-189
16310275-5	2006	RESULTS: Poly I:C pretreatment protected against T cell-mediated hepatitis, as evidenced by decreased mortality, hepatic necrosis, serum transaminase levels and inflammatory cytokines (IL-4, IFN-gamma).	Poly I-C	9-17	interferon gamma	Mus musculus	191-200
16436653-2	2006	We examined the potential influence of Toll-like receptors (TLRs), specifically TLR3 recognition of viral dsRNA exemplified by polyriboinosinic:polyribocytidylic acid [poly(I:C) RNA].	Poly I-C	127-166	toll like receptor 3	Homo sapiens	80-84
16472598-4	2006	The Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid, was used to activate innate immunity cells and mediators, including natural killer cells and interferon gamma.	Poly I-C	33-64	interferon gamma	Mus musculus	159-175
16472598-7	2006	The observed protective effect of polyinosinic-polycytidylic acid on liver fibrosis was diminished through either depletion of natural killer cells or by disruption of the interferon gamma gene.	Poly I-C	34-65	interferon gamma	Mus musculus	172-188
16472598-9	2006	Moreover, treatment with polyinosinic-polycytidylic acid or interferon gamma enhanced the cytotoxicity of natural killer cells against activated hepatic stellate cells and increased the expression of NKG2D and tumor necrosis factor-related apoptosis-inducing ligand on liver natural killer cells.	Poly I-C	25-56	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	200-265
16472598-10	2006	Blocking NKG2D or tumor necrosis factor-related apoptosis-inducing ligand with neutralizing antibodies markedly diminished the cytotoxicity of polyinosinic-polycytidylic acid-activated natural killer cells against activated hepatic stellate cells.	Poly I-C	143-174	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	9-73
16424161-4	2006	Although T cells did not respond directly to poly(I:C), we observed a dramatic increase in IFN-gamma secretion and an up-regulation of CD69 when freshly isolated gammadelta T cells were stimulated via TCR in the presence of poly(I:C) without APC.	Poly I-C	224-232	interferon gamma	Homo sapiens	91-100
16424161-4	2006	Although T cells did not respond directly to poly(I:C), we observed a dramatic increase in IFN-gamma secretion and an up-regulation of CD69 when freshly isolated gammadelta T cells were stimulated via TCR in the presence of poly(I:C) without APC.	Poly I-C	224-232	CD69 molecule	Homo sapiens	135-139
16424161-4	2006	Although T cells did not respond directly to poly(I:C), we observed a dramatic increase in IFN-gamma secretion and an up-regulation of CD69 when freshly isolated gammadelta T cells were stimulated via TCR in the presence of poly(I:C) without APC.	Poly I-C	224-232	APC regulator of WNT signaling pathway	Homo sapiens	242-245
16393995-5	2006	RFP inhibited activation of the IFN-stimulated response element and/or NF-kappaB mediated by the IKK family members and triggered by TNF, IL-1, polyinosinic-polycytidylic acid (ligand for TLR3), and viral infection.	Poly I-C	144-175	tripartite motif containing 27	Homo sapiens	0-3
16393995-5	2006	RFP inhibited activation of the IFN-stimulated response element and/or NF-kappaB mediated by the IKK family members and triggered by TNF, IL-1, polyinosinic-polycytidylic acid (ligand for TLR3), and viral infection.	Poly I-C	144-175	nuclear factor kappa B subunit 1	Homo sapiens	71-80
16393995-6	2006	Moreover, knockdown of RFP expression by RNA interference-enhanced activation of IFN-stimulated response element and/or NF-kappaB triggered by polyinosinic-polycytidylic acid, TNF, and IL-1.	Poly I-C	143-174	tripartite motif containing 27	Homo sapiens	23-26
16393995-6	2006	Moreover, knockdown of RFP expression by RNA interference-enhanced activation of IFN-stimulated response element and/or NF-kappaB triggered by polyinosinic-polycytidylic acid, TNF, and IL-1.	Poly I-C	143-174	nuclear factor kappa B subunit 1	Homo sapiens	120-129
16293707-7	2006	Poly (I:C) challenge 1) activated nuclear factor-kappaB (NF-kappaB), 2) increased IL-8 release, and 3) up-regulated NKG2D ligands and NK-cell-mediated lysis of muscle cells.	Poly I-C	0-9	nuclear factor kappa B subunit 1	Homo sapiens	57-70
16876672-8	2006	Poly I:C was also able to induce iNOS transcript expression in splenocytes, albeit at a later timing (i.e.24 h).	Poly I-C	0-8	nitric oxide synthase 2	Gallus gallus	33-37
16293707-7	2006	Poly (I:C) challenge 1) activated nuclear factor-kappaB (NF-kappaB), 2) increased IL-8 release, and 3) up-regulated NKG2D ligands and NK-cell-mediated lysis of muscle cells.	Poly I-C	0-9	interleukin 3	Homo sapiens	82-101
16490936-7	2006	RESULTS: Poly IC enhanced the expression of IP-10 mRNA and protein in concentration- and time-dependent manners.	Poly I-C	9-16	C-X-C motif chemokine ligand 10	Homo sapiens	44-49
17337762-4	2006	We also demonstrate that activation of NK cells with the TLR 3 ligand poly I:C results in a substantial increase in the number of organ-associated NK cells.	Poly I-C	70-78	toll like receptor 3	Homo sapiens	57-62
16504293-9	2006	Moreover, polyinosinic polycytidylic acid (poly I:C) induced increased GBP transcript levels in RTS11 and RTG2 cells after 4-6 h of stimulation, and in head kidney and liver of live fish after 24 h. These studies suggest that rbtGBP is an early response gene in rainbow trout, which may have similar functions in IFN-gamma mediated responses as mammalian GBPs.	Poly I-C	10-41	glycogen synthase kinase binding protein	Oncorhynchus mykiss	71-74
16504293-9	2006	Moreover, polyinosinic polycytidylic acid (poly I:C) induced increased GBP transcript levels in RTS11 and RTG2 cells after 4-6 h of stimulation, and in head kidney and liver of live fish after 24 h. These studies suggest that rbtGBP is an early response gene in rainbow trout, which may have similar functions in IFN-gamma mediated responses as mammalian GBPs.	Poly I-C	10-41	interferon, gamma	Oncorhynchus mykiss	313-322
16423036-0	2006	Toll-like receptor 3 agonist poly(I:C)-induced antiviral response in human corneal epithelial cells.	Poly I-C	29-38	toll like receptor 3	Homo sapiens	0-20
16423036-1	2006	The objective of this study was to examine the expression of Toll-like receptor 3 (TLR3) by human corneal epithelial cells (HCECs) and to determine whether exposure to the TLR3 agonist polyinosinic-polycytidylic acid [poly(I:C)] induces an antiviral response in these cells.	Poly I-C	185-216	toll like receptor 3	Homo sapiens	172-176
16423036-1	2006	The objective of this study was to examine the expression of Toll-like receptor 3 (TLR3) by human corneal epithelial cells (HCECs) and to determine whether exposure to the TLR3 agonist polyinosinic-polycytidylic acid [poly(I:C)] induces an antiviral response in these cells.	Poly I-C	218-227	toll like receptor 3	Homo sapiens	172-176
16423036-7	2006	Furthermore, incubation of HCECs with an endosomal acidification inhibitor, chloroquine, markedly inhibited poly(I:C)-mediated IFN-beta expression in HCECs.	Poly I-C	108-117	interferon beta 1	Homo sapiens	127-135
17150911-1	2006	Toll-like receptor 3 (TLR3) recognizes dsRNA of viral origin and polyriboinosine-polyribocytidylic acid (poly (I:C)).	Poly I-C	105-115	toll like receptor 3	Homo sapiens	0-20
17150911-1	2006	Toll-like receptor 3 (TLR3) recognizes dsRNA of viral origin and polyriboinosine-polyribocytidylic acid (poly (I:C)).	Poly I-C	105-115	toll like receptor 3	Homo sapiens	22-26
17150912-2	2006	While TLR3 preferentially recognizes polyriboinosine-polyribocytidylic acid (poly (I:C)), a sequence-specific dsRNA has not yet been shown to activate TLR3.	Poly I-C	77-87	toll like receptor 3	Homo sapiens	6-10
16316467-7	2005	Poly(I:C) induced an elevated expression of TLR1, TLR2 and TLR3 and increased the gene expression of the general TLR adaptor MyD88 and IRAK-2.	Poly I-C	0-8	toll like receptor 1	Homo sapiens	44-48
16287979-1	2005	This study demonstrates that pretreatment with polyinosinic-polycytidylic acid (poly I:C) significantly decreased the mortality and liver injury caused by injection of lipopolysaccharide (LPS) in the presence of d-galactosamine (d-GalN) in C57BL/6 mice.	Poly I-C	47-78	galanin and GMAP prepropeptide	Mus musculus	231-235
16287979-1	2005	This study demonstrates that pretreatment with polyinosinic-polycytidylic acid (poly I:C) significantly decreased the mortality and liver injury caused by injection of lipopolysaccharide (LPS) in the presence of d-galactosamine (d-GalN) in C57BL/6 mice.	Poly I-C	80-88	galanin and GMAP prepropeptide	Mus musculus	231-235
16287979-4	2005	Treatment with poly I:C down-regulated the expression of the toll-like receptor 4 (TLR4) on macrophages and reduced the sensitivity of macrophages (Kupffer cells and peritoneal macrophages from C57BL/6 mice, or RAW264.7 cells) to LPS stimulation.	Poly I-C	15-23	toll-like receptor 4	Mus musculus	61-81
16287979-4	2005	Treatment with poly I:C down-regulated the expression of the toll-like receptor 4 (TLR4) on macrophages and reduced the sensitivity of macrophages (Kupffer cells and peritoneal macrophages from C57BL/6 mice, or RAW264.7 cells) to LPS stimulation.	Poly I-C	15-23	toll-like receptor 4	Mus musculus	83-87
16144834-9	2005	The inhibitors of lysosome maturation, bafilomycin and chloroquine, inhibited the poly(I-C)-induced biological response in immune cells, showing that TLR3 interacted with its ligand in acidic subcellular compartments.	Poly I-C	82-91	toll like receptor 3	Homo sapiens	150-154
16384532-10	2005	RESULTS: Stimulation of TLR3-expressing cells with the synthetic TLR3 ligand, Poly I:C, resulted in the production of cytokines and chemokines important for endometrial function and regulation.	Poly I-C	78-86	toll like receptor 3	Homo sapiens	24-28
16384532-10	2005	RESULTS: Stimulation of TLR3-expressing cells with the synthetic TLR3 ligand, Poly I:C, resulted in the production of cytokines and chemokines important for endometrial function and regulation.	Poly I-C	78-86	toll like receptor 3	Homo sapiens	65-69
16384532-11	2005	Suppression of Poly I:C-induced cytokine and chemokine production by cells treated with 10(-8) M E2, but not cells treated with 10(-7) M P, was observed in endometrial epithelial cell lines expressing TLR3 and estrogen receptor alpha (ERalpha).	Poly I-C	15-23	toll like receptor 3	Homo sapiens	201-205
16384532-11	2005	Suppression of Poly I:C-induced cytokine and chemokine production by cells treated with 10(-8) M E2, but not cells treated with 10(-7) M P, was observed in endometrial epithelial cell lines expressing TLR3 and estrogen receptor alpha (ERalpha).	Poly I-C	15-23	estrogen receptor 1	Homo sapiens	210-233
16384532-11	2005	Suppression of Poly I:C-induced cytokine and chemokine production by cells treated with 10(-8) M E2, but not cells treated with 10(-7) M P, was observed in endometrial epithelial cell lines expressing TLR3 and estrogen receptor alpha (ERalpha).	Poly I-C	15-23	estrogen receptor 1	Homo sapiens	235-242
16384532-14	2005	However, treatment with E2 did suppress cytokine and chemokine production resulting from TLR3 stimulation with Poly I:C, suggesting that E2 modulates TLR3 function.	Poly I-C	111-119	toll like receptor 3	Homo sapiens	89-93
16384532-14	2005	However, treatment with E2 did suppress cytokine and chemokine production resulting from TLR3 stimulation with Poly I:C, suggesting that E2 modulates TLR3 function.	Poly I-C	111-119	toll like receptor 3	Homo sapiens	150-154
16166091-3	2005	C/EBPalpha itself was completely ablated in the liver by day 4 after the injection of poly(I:C).	Poly I-C	86-95	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	0-10
16316467-7	2005	Poly(I:C) induced an elevated expression of TLR1, TLR2 and TLR3 and increased the gene expression of the general TLR adaptor MyD88 and IRAK-2.	Poly I-C	0-8	toll like receptor 2	Homo sapiens	50-54
16316467-7	2005	Poly(I:C) induced an elevated expression of TLR1, TLR2 and TLR3 and increased the gene expression of the general TLR adaptor MyD88 and IRAK-2.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	59-63
16316467-7	2005	Poly(I:C) induced an elevated expression of TLR1, TLR2 and TLR3 and increased the gene expression of the general TLR adaptor MyD88 and IRAK-2.	Poly I-C	0-8	MYD88 innate immune signal transduction adaptor	Homo sapiens	125-130
16316467-7	2005	Poly(I:C) induced an elevated expression of TLR1, TLR2 and TLR3 and increased the gene expression of the general TLR adaptor MyD88 and IRAK-2.	Poly I-C	0-8	interleukin 1 receptor associated kinase 2	Homo sapiens	135-141
16115877-2	2005	Cytokine production is impaired when rip1-/- cells are treated with TNF-alpha, poly(I-C), or lipopolysaccharide, implicating Rip1 in the Trif-dependent TLR3 and TLR4 pathways.	Poly I-C	79-88	receptor interacting serine/threonine kinase 1	Homo sapiens	37-41
16115877-2	2005	Cytokine production is impaired when rip1-/- cells are treated with TNF-alpha, poly(I-C), or lipopolysaccharide, implicating Rip1 in the Trif-dependent TLR3 and TLR4 pathways.	Poly I-C	79-88	receptor interacting serine/threonine kinase 1	Homo sapiens	125-129
16115877-2	2005	Cytokine production is impaired when rip1-/- cells are treated with TNF-alpha, poly(I-C), or lipopolysaccharide, implicating Rip1 in the Trif-dependent TLR3 and TLR4 pathways.	Poly I-C	79-88	TIR domain containing adaptor molecule 1	Homo sapiens	137-141
16115877-2	2005	Cytokine production is impaired when rip1-/- cells are treated with TNF-alpha, poly(I-C), or lipopolysaccharide, implicating Rip1 in the Trif-dependent TLR3 and TLR4 pathways.	Poly I-C	79-88	toll like receptor 3	Homo sapiens	152-156
16115877-2	2005	Cytokine production is impaired when rip1-/- cells are treated with TNF-alpha, poly(I-C), or lipopolysaccharide, implicating Rip1 in the Trif-dependent TLR3 and TLR4 pathways.	Poly I-C	79-88	toll like receptor 4	Homo sapiens	161-165
16179587-8	2005	Furthermore, there was selective upregulation of plasma IL-12 in apoE knockout mice by a TLR3 agonist, poly I:C, but not by other TLR agonists, CpG oligonucleotide or Toxoplasma gondii antigen.	Poly I-C	103-111	apolipoprotein E	Mus musculus	65-69
16264039-11	2005	Poly(IC)-induced upregulation of IL-4Ralpha was inhibited by treatment with cycloheximide or dexamethasone.	Poly I-C	0-8	interleukin 4 receptor	Homo sapiens	33-43
16081598-6	2005	With RAW 264.7 cells, lipoteichoic acid and polyinosinic-polycytidylic acid, like LPS, stimulated HMGB1 release as well as cytokine production.	Poly I-C	44-75	toll-like receptor 4	Mus musculus	82-85
16027122-3	2005	We have previously observed by microarray analysis that PIC induces expression of several mRNAs encoding for genes downstream of Toll-like receptor 3 (TLR3) signaling pathway.	Poly I-C	56-59	toll-like receptor 3	Rattus norvegicus	129-149
16027122-3	2005	We have previously observed by microarray analysis that PIC induces expression of several mRNAs encoding for genes downstream of Toll-like receptor 3 (TLR3) signaling pathway.	Poly I-C	56-59	toll-like receptor 3	Rattus norvegicus	151-155
15864589-11	2005	We conclude that poly(I:C) matured IL-3-DC and GM-CSF-DC share similar phenotype and functional properties including the capacity to prime tumor-associated antigen specific CTL.	Poly I-C	17-25	interleukin 3	Homo sapiens	35-42
16186222-4	2005	In this study, evidence is provided that bICP0 represses the human beta interferon (IFN-beta) promoter and a simple promoter with consensus IFN-stimulated response elements following stimulation with double-stranded RNA (polyinosinic-polycytidylic acid), IFN regulatory factor 3 (IRF3) or IRF7.	Poly I-C	221-252	ubiquitin E3 ligase ICP0	Bovine alphaherpesvirus 1	41-46
16081598-6	2005	With RAW 264.7 cells, lipoteichoic acid and polyinosinic-polycytidylic acid, like LPS, stimulated HMGB1 release as well as cytokine production.	Poly I-C	44-75	high mobility group box 1	Mus musculus	98-103
16087162-4	2005	Poly(I:C) treatment induced MIP-1alpha production, interestingly, poly(I:C)-induced IFN-alpha and -beta production preceded MIP-1alpha production.	Poly I-C	0-8	C-C motif chemokine ligand 3	Homo sapiens	28-38
16183870-5	2005	The potential effect of poly (I:C) on CD200 expression was also evaluated by detecting the CD200+ CK7+ percentage in trophoblast cells incubated in the presence or absence of poly (I:C), in vitro.	Poly I-C	24-33	CD200 antigen	Mus musculus	38-43
16086371-13	2005	In addition, other apoptotic markers including the cleaved forms of caspase-3 and poly(ADP)ribose polymerase (PARP) were found to be lower in EBER-expressing NP69 cells after treatment with pIC.	Poly I-C	190-193	caspase 3	Homo sapiens	68-77
16086371-13	2005	In addition, other apoptotic markers including the cleaved forms of caspase-3 and poly(ADP)ribose polymerase (PARP) were found to be lower in EBER-expressing NP69 cells after treatment with pIC.	Poly I-C	190-193	poly(ADP-ribose) polymerase 1	Homo sapiens	82-108
16086371-13	2005	In addition, other apoptotic markers including the cleaved forms of caspase-3 and poly(ADP)ribose polymerase (PARP) were found to be lower in EBER-expressing NP69 cells after treatment with pIC.	Poly I-C	190-193	poly(ADP-ribose) polymerase 1	Homo sapiens	110-114
16087162-4	2005	Poly(I:C) treatment induced MIP-1alpha production, interestingly, poly(I:C)-induced IFN-alpha and -beta production preceded MIP-1alpha production.	Poly I-C	0-8	C-C motif chemokine ligand 3	Homo sapiens	124-134
16087162-4	2005	Poly(I:C) treatment induced MIP-1alpha production, interestingly, poly(I:C)-induced IFN-alpha and -beta production preceded MIP-1alpha production.	Poly I-C	66-75	C-C motif chemokine ligand 3	Homo sapiens	28-38
16087162-4	2005	Poly(I:C) treatment induced MIP-1alpha production, interestingly, poly(I:C)-induced IFN-alpha and -beta production preceded MIP-1alpha production.	Poly I-C	66-75	interferon alpha 1	Homo sapiens	84-103
16087162-4	2005	Poly(I:C) treatment induced MIP-1alpha production, interestingly, poly(I:C)-induced IFN-alpha and -beta production preceded MIP-1alpha production.	Poly I-C	66-75	C-C motif chemokine ligand 3	Homo sapiens	124-134
16087162-6	2005	IFN-alpha priming enhanced TLR3 expression and MIP-1alpha production in poly(I:C)-treated keratinocytes.	Poly I-C	72-81	interferon alpha 1	Homo sapiens	0-9
16087162-6	2005	IFN-alpha priming enhanced TLR3 expression and MIP-1alpha production in poly(I:C)-treated keratinocytes.	Poly I-C	72-81	toll like receptor 3	Homo sapiens	27-31
16087162-6	2005	IFN-alpha priming enhanced TLR3 expression and MIP-1alpha production in poly(I:C)-treated keratinocytes.	Poly I-C	72-81	C-C motif chemokine ligand 3	Homo sapiens	47-57
15840693-2	2005	dsRNA, synthesized by various types of viruses and mimicked by polyinosinic-polycytidylic acid (poly(I:C)) is recognized by Toll-like receptor 3 (TLR3).	Poly I-C	63-94	toll-like receptor 3	Mus musculus	124-144
16111680-7	2005	Duox2 expression was also elevated by polyinosine-polycytidylic acid (poly(I:C)) and rhinovirus infection.	Poly I-C	70-79	dual oxidase 2	Homo sapiens	0-5
16142732-3	2005	TLR-3 signaling was assessed by incubating RASFs with poly(I-C), lipopolysaccharide, palmitoyl-3-cysteine-serine-lysine-4, or necrotic synovial fluid cells from RA patients in the presence or absence of hydroxychloroquine or Benzonase.	Poly I-C	54-63	toll like receptor 3	Homo sapiens	0-5
15840693-2	2005	dsRNA, synthesized by various types of viruses and mimicked by polyinosinic-polycytidylic acid (poly(I:C)) is recognized by Toll-like receptor 3 (TLR3).	Poly I-C	63-94	toll-like receptor 3	Mus musculus	146-150
16034103-4	2005	TLR3 is expressed at the cell surface where it functions as a receptor for polyinosinic acid:cytidylic acid (poly(I:C)) in a lysosomal-independent manner.	Poly I-C	109-118	toll like receptor 3	Homo sapiens	0-4
15845391-0	2005	Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines.	Poly I-C	22-29	toll like receptor 3	Homo sapiens	14-18
15910497-7	2005	Poly I:C injection induced IFN-alpha.	Poly I-C	0-8	interferon alpha	Mus musculus	27-36
16000950-7	2005	These BDCs could be activated ex vivo with poly I:C or LPS.	Poly I-C	43-51	BZX	Homo sapiens	6-10
15899864-8	2005	These effects are exacerbated after activation of the interferon/OAS1A/RNase L pathway by poly(I-C).	Poly I-C	90-98	2'-5' oligoadenylate synthetase 1A	Mus musculus	65-70
15899864-8	2005	These effects are exacerbated after activation of the interferon/OAS1A/RNase L pathway by poly(I-C).	Poly I-C	90-98	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	Mus musculus	71-78
15845391-4	2005	Stimulation with polyI:C elicited the elevated production and mRNA expression of IL-6 and IL-8 in HCEC.	Poly I-C	17-24	interleukin 6	Homo sapiens	81-85
15845391-4	2005	Stimulation with polyI:C elicited the elevated production and mRNA expression of IL-6 and IL-8 in HCEC.	Poly I-C	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
15845391-5	2005	While polyI:C induced IFN-beta, far stronger than human fibroblasts, and TLR3 gene expression in HCEC, LPS stimulation did not.	Poly I-C	6-13	interferon beta 1	Homo sapiens	22-30
15845391-6	2005	Similarly, polyI:C, but not LPS, induced the gene expression of IkappaBalpha and MAIL, members of the IkappaB family, in HCEC.	Poly I-C	11-18	NFKB inhibitor alpha	Homo sapiens	64-76
15781259-4	2005	B7-H1 and B7-DC were constitutively expressed on the cells, and their expression was profoundly upregulated by stimulation with an analog of viral dsRNA, polyinosinic-polycytidylic acid.	Poly I-C	154-185	CD274 antigen	Mus musculus	0-5
15879132-4	2005	Poly(I:C)-induced IL-8 was concentration dependent (2-100 mug/ml) and displayed slower kinetics compared with IL-8 induced by bacterial flagellin (ET(50) approximately 24 vs 8 h poly(I:C) vs flagellin, respectively).	Poly I-C	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
15879132-6	2005	Conversely, poly(I:C)-induced phosphorylation of PKR and inhibitors of PKR, 2-aminopurine and adenine, ablated poly(I:C)-induced gene expression but had no effect on gene expression induced by flagellin, thus suggesting that intestinal epithelial cell detection of dsRNA relies on PKR.	Poly I-C	12-21	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	49-52
15879132-6	2005	Conversely, poly(I:C)-induced phosphorylation of PKR and inhibitors of PKR, 2-aminopurine and adenine, ablated poly(I:C)-induced gene expression but had no effect on gene expression induced by flagellin, thus suggesting that intestinal epithelial cell detection of dsRNA relies on PKR.	Poly I-C	12-21	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	71-74
15879132-6	2005	Conversely, poly(I:C)-induced phosphorylation of PKR and inhibitors of PKR, 2-aminopurine and adenine, ablated poly(I:C)-induced gene expression but had no effect on gene expression induced by flagellin, thus suggesting that intestinal epithelial cell detection of dsRNA relies on PKR.	Poly I-C	12-21	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	71-74
15879132-6	2005	Conversely, poly(I:C)-induced phosphorylation of PKR and inhibitors of PKR, 2-aminopurine and adenine, ablated poly(I:C)-induced gene expression but had no effect on gene expression induced by flagellin, thus suggesting that intestinal epithelial cell detection of dsRNA relies on PKR.	Poly I-C	111-120	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	49-52
15879132-6	2005	Conversely, poly(I:C)-induced phosphorylation of PKR and inhibitors of PKR, 2-aminopurine and adenine, ablated poly(I:C)-induced gene expression but had no effect on gene expression induced by flagellin, thus suggesting that intestinal epithelial cell detection of dsRNA relies on PKR.	Poly I-C	111-120	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	71-74
15879132-6	2005	Conversely, poly(I:C)-induced phosphorylation of PKR and inhibitors of PKR, 2-aminopurine and adenine, ablated poly(I:C)-induced gene expression but had no effect on gene expression induced by flagellin, thus suggesting that intestinal epithelial cell detection of dsRNA relies on PKR.	Poly I-C	111-120	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	71-74
15879132-7	2005	Consistent with poly(I:C) detection by an intracellular molecule such as PKR, we observed that both uptake of and responses to poly(I:C) were polarized to the basolateral side.	Poly I-C	16-24	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	73-76
15879132-7	2005	Consistent with poly(I:C) detection by an intracellular molecule such as PKR, we observed that both uptake of and responses to poly(I:C) were polarized to the basolateral side.	Poly I-C	16-25	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	73-76
15650060-4	2005	Stimulation of hOSCAR acts in conjunction with the Toll-like receptor (TLR) ligands, lipopolysaccharide (LPS), R-848, and polyinosinic-polycytidylic acid (poly(I:C)), to increase the expression of maturation markers, and to modulate cytokine release.	Poly I-C	122-153	osteoclast associated Ig-like receptor	Homo sapiens	15-21
15838378-1	2005	Poly(I:C), a synthetic double-stranded RNA polymer and a TLR3 agonist, can be used as a vaccine adjuvant to enhance adaptive immunity.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	57-61
15838378-6	2005	In contrast, peptide vaccination with concomitant administration of poly(I:C) resulted in a dramatic sustained increase in the number of antigen-specific CD8 T cells.	Poly I-C	68-77	CD8a molecule	Homo sapiens	154-157
15838378-8	2005	The adjuvant effects of poly(I:C) appear to be at least partially dependent on an increase in the transcription of the anti-apoptotic molecules Bcl-3 and Bcl-xL and a concomitant decrease in apoptosis during the contraction phase of the primary T-cell response.	Poly I-C	24-32	BCL3 transcription coactivator	Homo sapiens	144-149
15838378-8	2005	The adjuvant effects of poly(I:C) appear to be at least partially dependent on an increase in the transcription of the anti-apoptotic molecules Bcl-3 and Bcl-xL and a concomitant decrease in apoptosis during the contraction phase of the primary T-cell response.	Poly I-C	24-32	BCL2 like 1	Homo sapiens	154-160
15897244-0	2005	The role of IFN regulatory factor-3 in the cytotoxic activity of NS-9, a polyinosinic-polycytidylic acid/cationic liposome complex, against tumor cells.	Poly I-C	73-104	interferon regulatory factor 3	Homo sapiens	12-35
15897244-0	2005	The role of IFN regulatory factor-3 in the cytotoxic activity of NS-9, a polyinosinic-polycytidylic acid/cationic liposome complex, against tumor cells.	Poly I-C	73-104	SOS Ras/Rho guanine nucleotide exchange factor 2	Homo sapiens	65-69
15897244-1	2005	NS-9 is a complex of polyinosinic-polycytidylic acid and a novel cationic liposome, LIC-101.	Poly I-C	21-52	SOS Ras/Rho guanine nucleotide exchange factor 2	Homo sapiens	0-4
15737993-4	2005	In contrast, the addition of poly(I-C) to culture media activates the IFN-beta promoter and results in robust expression of IFN-stimulated genes (ISG) in PH5CH8 cells, which are derived from non-neoplastic hepatocytes transformed with large T antigen.	Poly I-C	29-37	interferon beta 1	Sus scrofa	70-78
15781259-4	2005	B7-H1 and B7-DC were constitutively expressed on the cells, and their expression was profoundly upregulated by stimulation with an analog of viral dsRNA, polyinosinic-polycytidylic acid.	Poly I-C	154-185	programmed cell death 1 ligand 2	Mus musculus	10-15
15793267-3	2005	The dominant diabetes susceptibility locus Iddm4 is required for diabetes induced by treatment with poly I:C plus Treg depletion.	Poly I-C	100-108	Insulin dependent diabetes mellitus QTL 8	Rattus norvegicus	43-48
15793267-5	2005	Surprisingly, an analysis of 190 (BBDR x WF)F2 rats treated with KRV after brief exposure to poly I:C revealed that the BBDR-origin allele of Iddm4 is necessary but not entirely sufficient for diabetes expression.	Poly I-C	93-101	Insulin dependent diabetes mellitus QTL 8	Rattus norvegicus	142-147
15962714-2	2005	Poly IC enhanced the expression of MCP-1 and release of mononuclear cell chemotactic activity, which were inhibited by dexamethasone pre-treatment.	Poly I-C	0-7	chemokine (C-C motif) ligand 2	Mus musculus	35-40
15794745-5	2005	Polyinosinic-polycytidylic acid (poly I:C) treatment enhanced the activity of PKR induced by IFN, but did not overcome the PMA-induced reduction of PKR autophosphorylation.	Poly I-C	0-31	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	78-81
15778392-9	2005	Similarly, IFN-alpha pretreatment strongly enhanced poly(I:C)-induced activation of IFN-beta, IL-28, and IL-29 genes also in HUVECs.	Poly I-C	52-61	interferon alpha 1	Homo sapiens	11-20
15778392-9	2005	Similarly, IFN-alpha pretreatment strongly enhanced poly(I:C)-induced activation of IFN-beta, IL-28, and IL-29 genes also in HUVECs.	Poly I-C	52-61	interferon beta 1	Homo sapiens	84-92
15778392-9	2005	Similarly, IFN-alpha pretreatment strongly enhanced poly(I:C)-induced activation of IFN-beta, IL-28, and IL-29 genes also in HUVECs.	Poly I-C	52-61	interferon lambda 3	Homo sapiens	94-99
15778392-9	2005	Similarly, IFN-alpha pretreatment strongly enhanced poly(I:C)-induced activation of IFN-beta, IL-28, and IL-29 genes also in HUVECs.	Poly I-C	52-61	interferon lambda 1	Homo sapiens	105-110
15683451-5	2005	Polyriboinosinic polyribocytidylic acid (Poly I:C) + tumour necrosis factor-alpha (TNF-alpha) induced significant IL-12 p70 secretion, which was increased after addition of a decoy IL-10 receptor.	Poly I-C	0-39	tumor necrosis factor	Homo sapiens	83-92
15730392-7	2005	Expansion of CD8(+) T cell numbers was generally higher following priming with CD40-L than with polyinosinic-polycytidylic acid (poly I:C) matured DCs.	Poly I-C	96-127	CD8a molecule	Homo sapiens	13-16
15730392-7	2005	Expansion of CD8(+) T cell numbers was generally higher following priming with CD40-L than with polyinosinic-polycytidylic acid (poly I:C) matured DCs.	Poly I-C	129-137	CD8a molecule	Homo sapiens	13-16
15675953-4	2005	With regard to Th1-type chemokines, exogenous stimulus, such as interferon-gamma (IFN-gamma), lipopolysaccharide, or polyinosinic-polycytidylic acid, was mandatory for the production of substantial amounts of CXCL10, CXCL9, and CXCL11 both in LC and splenic DC.	Poly I-C	117-148	chemokine (C-X-C motif) ligand 10	Mus musculus	209-215
15675953-4	2005	With regard to Th1-type chemokines, exogenous stimulus, such as interferon-gamma (IFN-gamma), lipopolysaccharide, or polyinosinic-polycytidylic acid, was mandatory for the production of substantial amounts of CXCL10, CXCL9, and CXCL11 both in LC and splenic DC.	Poly I-C	117-148	chemokine (C-X-C motif) ligand 9	Mus musculus	217-222
15675953-4	2005	With regard to Th1-type chemokines, exogenous stimulus, such as interferon-gamma (IFN-gamma), lipopolysaccharide, or polyinosinic-polycytidylic acid, was mandatory for the production of substantial amounts of CXCL10, CXCL9, and CXCL11 both in LC and splenic DC.	Poly I-C	117-148	chemokine (C-X-C motif) ligand 11	Mus musculus	228-234
15618008-1	2005	Toll-like receptor (TLR) 3 and 4 mediate the expression of many genes, including NF-kappaB- and interferon-regulatory factor (IRF)-3/interferon (IFN)-inducible genes, in macrophages and dendritic cells (DCs) in response to their ligand stimuli, polyI:C and lipopolysaccharide (LPS).	Poly I-C	245-252	interferon alpha 1	Homo sapiens	145-148
16502342-0	2005	Polyinosinic-polycytidylic acid induces the expression of GRO-alpha in BEAS-2B cells.	Poly I-C	0-31	C-X-C motif chemokine ligand 1	Homo sapiens	58-67
16502342-2	2005	Polyinosinic-polycytidylic acid (poly IC) is a synthetic double-stranded RNA (dsRNA), which is a ligand for Toll-like receptor-3.	Poly I-C	0-31	toll like receptor 3	Homo sapiens	108-128
16502342-4	2005	In the present study, we found the induction of GRO-alpha in BEAS-2B bronchial epithelial cells treated with poly IC.	Poly I-C	109-116	C-X-C motif chemokine ligand 1	Homo sapiens	48-57
15659550-8	2005	This previously undescribed kinase, designated PKZ (protein kinase containing Z-DNA binding domains), is transcribed constitutively at low levels and is highly induced after injection of poly(inosinic)-poly(cytidylic) acid, which simulates viral infection.	Poly I-C	187-222	protein kinase containing Z-DNA binding domains	Danio rerio	47-50
15313929-7	2004	In vivo stimulation of mice with pIC and CpG-ODN demonstrated synergy for serum IL-6 and IL-12p40 levels that correlated with an enhanced antitumor effect against established B16-F10 experimental pulmonary metastases.	Poly I-C	33-36	interleukin 6	Mus musculus	80-84
15634923-5	2005	In addition, poly(I:C) exposure induced the mRNA expression of HBD1 and HBD2 by 6- and 4-fold, respectively.	Poly I-C	13-22	defensin beta 1	Homo sapiens	63-67
15634923-5	2005	In addition, poly(I:C) exposure induced the mRNA expression of HBD1 and HBD2 by 6- and 4-fold, respectively.	Poly I-C	13-22	defensin beta 4A	Homo sapiens	72-76
15784293-0	2005	Poly I:C induces an antiviral state against Ictalurid Herpesvirus 1 and Mx1 transcription in the channel catfish (Ictalurus punctatus).	Poly I-C	0-8	MX dynamin like GTPase 1	Homo sapiens	72-75
15784293-7	2005	Mx1 mRNA was significantly elevated in all organs only at day 1 post-injection with poly I:C.	Poly I-C	84-92	MX dynamin like GTPase 1	Homo sapiens	0-3
15315972-3	2004	Our results show that treatment with poly I:C significantly up-regulates both natural and CD16-mediated cytotoxicity of highly purified human NK cells.	Poly I-C	37-45	Fc gamma receptor IIIa	Homo sapiens	90-94
15315972-4	2004	Poly I:C also induces the novel capability of producing CXCL10 chemokine in human NK cells and synergistically enhances interferon-gamma (IFN-gamma) production induced by either adaptive or innate cytokines.	Poly I-C	0-8	C-X-C motif chemokine ligand 10	Homo sapiens	56-62
15315972-4	2004	Poly I:C also induces the novel capability of producing CXCL10 chemokine in human NK cells and synergistically enhances interferon-gamma (IFN-gamma) production induced by either adaptive or innate cytokines.	Poly I-C	0-8	interferon gamma	Homo sapiens	120-136
15315972-4	2004	Poly I:C also induces the novel capability of producing CXCL10 chemokine in human NK cells and synergistically enhances interferon-gamma (IFN-gamma) production induced by either adaptive or innate cytokines.	Poly I-C	0-8	interferon gamma	Homo sapiens	138-147
15315972-5	2004	In accordance with the expression of Toll-like receptor-3 (TLR3) and of TRIF/TICAM-1 adaptor, poly I:C stimulation induces the activation of interferon regulatory factor-3 (IRF-3) transcription factor and of p38 mitogen-activated protein kinase (MAPK) in human NK cells.	Poly I-C	94-102	toll like receptor 3	Homo sapiens	37-57
15315972-5	2004	In accordance with the expression of Toll-like receptor-3 (TLR3) and of TRIF/TICAM-1 adaptor, poly I:C stimulation induces the activation of interferon regulatory factor-3 (IRF-3) transcription factor and of p38 mitogen-activated protein kinase (MAPK) in human NK cells.	Poly I-C	94-102	interferon regulatory factor 3	Homo sapiens	141-171
15315972-5	2004	In accordance with the expression of Toll-like receptor-3 (TLR3) and of TRIF/TICAM-1 adaptor, poly I:C stimulation induces the activation of interferon regulatory factor-3 (IRF-3) transcription factor and of p38 mitogen-activated protein kinase (MAPK) in human NK cells.	Poly I-C	94-102	interferon regulatory factor 3	Homo sapiens	173-178
15315972-5	2004	In accordance with the expression of Toll-like receptor-3 (TLR3) and of TRIF/TICAM-1 adaptor, poly I:C stimulation induces the activation of interferon regulatory factor-3 (IRF-3) transcription factor and of p38 mitogen-activated protein kinase (MAPK) in human NK cells.	Poly I-C	94-102	mitogen-activated protein kinase 14	Homo sapiens	208-211
15507313-7	2004	Since a similar increase in the degree of the IFN-gamma response to the PRRSV vaccine could be achieved by substituting polyinosinic-polycytidylic acid in lieu of either cytokine, exposure to PRRSV in the presence of a variety of Th 1 polarizing molecules can positively influence the development of the cell-mediated immune response of swine to this pathogen.	Poly I-C	120-151	interferon gamma	Homo sapiens	46-55
15313511-6	2004	Poly I:C stimulation induced several genes but the strongest and significant response was observed in the Mx-1 and Vig-8 genes.	Poly I-C	0-8	MX dynamin like GTPase 1	Homo sapiens	106-120
15205185-11	2004	IL-1beta and cyclooxygenase-2 mRNA were significantly upregulated in the hypothalamus of poly I:C-treated animals.	Poly I-C	89-97	interleukin 1 beta	Rattus norvegicus	0-8
15205185-11	2004	IL-1beta and cyclooxygenase-2 mRNA were significantly upregulated in the hypothalamus of poly I:C-treated animals.	Poly I-C	89-97	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	13-29
15521020-4	2004	Murine cytomegalovirus (MCMV) infection and the TLR3 ligand polyinosinic-polycytidylic acid [poly(I:C)] were used to activate innate immunity.	Poly I-C	60-91	toll like receptor 3	Homo sapiens	48-52
15521020-4	2004	Murine cytomegalovirus (MCMV) infection and the TLR3 ligand polyinosinic-polycytidylic acid [poly(I:C)] were used to activate innate immunity.	Poly I-C	93-102	toll like receptor 3	Homo sapiens	48-52
15521020-7	2004	Depletion of NK cells or disruption of either the IFN-gamma gene or the IFN-gamma receptor gene enhances liver regeneration and partially abolishes the negative effects of MCMV and polyI:C on liver regeneration, whereas NKT cells may only play a minor role in suppression of liver regeneration.	Poly I-C	181-188	interferon gamma	Mus musculus	72-81
15521020-8	2004	Adoptive transfer of IFN-gamma +/+ NK cells, but not IFN-gamma -/- NK cells, restores the ability of polyI:C to attenuate liver regeneration in NK-depleted mice.	Poly I-C	101-108	interferon gamma	Mus musculus	21-30
15521020-9	2004	Finally, administration of polyI:C or IFN-gamma enhances expression of several antiproliferative proteins, including STAT1, IRF-1, and p21cip1/waf1 in the livers of partially hepatectomized mice.	Poly I-C	27-34	signal transducer and activator of transcription 1	Mus musculus	117-122
15521020-9	2004	Finally, administration of polyI:C or IFN-gamma enhances expression of several antiproliferative proteins, including STAT1, IRF-1, and p21cip1/waf1 in the livers of partially hepatectomized mice.	Poly I-C	27-34	interferon regulatory factor 1	Mus musculus	124-129
15521020-9	2004	Finally, administration of polyI:C or IFN-gamma enhances expression of several antiproliferative proteins, including STAT1, IRF-1, and p21cip1/waf1 in the livers of partially hepatectomized mice.	Poly I-C	27-34	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	135-142
15521020-9	2004	Finally, administration of polyI:C or IFN-gamma enhances expression of several antiproliferative proteins, including STAT1, IRF-1, and p21cip1/waf1 in the livers of partially hepatectomized mice.	Poly I-C	27-34	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	143-147
15229216-5	2004	Expression of kinase-inactive PKR (K296R) in cells inhibited the poly(IC)-induced phosphorylation of MKK3/6 detected by phosphospecific antiserum but did not affect the poly(IC)-induced gel migration retardation of MKK3.	Poly I-C	65-73	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	30-33
15229216-5	2004	Expression of kinase-inactive PKR (K296R) in cells inhibited the poly(IC)-induced phosphorylation of MKK3/6 detected by phosphospecific antiserum but did not affect the poly(IC)-induced gel migration retardation of MKK3.	Poly I-C	65-73	mitogen-activated protein kinase kinase 3	Homo sapiens	101-105
15229216-5	2004	Expression of kinase-inactive PKR (K296R) in cells inhibited the poly(IC)-induced phosphorylation of MKK3/6 detected by phosphospecific antiserum but did not affect the poly(IC)-induced gel migration retardation of MKK3.	Poly I-C	65-73	mitogen-activated protein kinase kinase 3	Homo sapiens	215-219
15229216-6	2004	This suggests that poly(IC)-mediated in vivo activation of MKK6, but not MKK3, is through PKR.	Poly I-C	19-27	mitogen-activated protein kinase kinase 6	Homo sapiens	59-63
15229216-6	2004	This suggests that poly(IC)-mediated in vivo activation of MKK6, but not MKK3, is through PKR.	Poly I-C	19-27	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	90-93
15313929-7	2004	In vivo stimulation of mice with pIC and CpG-ODN demonstrated synergy for serum IL-6 and IL-12p40 levels that correlated with an enhanced antitumor effect against established B16-F10 experimental pulmonary metastases.	Poly I-C	33-36	interleukin 12b	Mus musculus	89-97
14698216-7	2004	Zebrafish liver cells produced high levels of Mx mRNA in response to induction by the known IFN-inducer polyinosinic-polycytidylic acid (Poly[I:C]).	Poly I-C	104-135	interferon phi 1	Danio rerio	92-95
15283851-5	2004	Poly IC enhanced the expression of galectin-9 mRNA and protein in concentration- and time-dependent manners.	Poly I-C	0-7	galectin 9	Homo sapiens	35-45
15283851-8	2004	We conclude that poly IC upregulates galectin-9 expression in the vascular endothelium and this may explain part of the mechanism for leucocyte traffic through the vascular wall.	Poly I-C	17-24	galectin 9	Homo sapiens	37-47
15196204-0	2004	Polyinosinic-polycytidylic acid-mediated stimulation of human gammadelta T cells via CD11c dendritic cell-derived type I interferons.	Poly I-C	0-31	integrin subunit alpha X	Homo sapiens	85-90
15196204-4	2004	Within peripheral blood mononuclear cells, poly(I:C)-stimulated gammadelta T cells expressed increased levels of CD69 and exhibited significantly enhanced antigen-mediated proliferation in response to isopentenylpyrophosphate (IPP).	Poly I-C	43-52	CD69 molecule	Homo sapiens	113-117
15196204-8	2004	In addition, the supernatant of poly(I:C)-treated CD11c(+) DC was able to mimic the stimulatory effects of poly(I:C) on gammadelta T cells.	Poly I-C	32-41	integrin subunit alpha X	Homo sapiens	50-55
15196204-8	2004	In addition, the supernatant of poly(I:C)-treated CD11c(+) DC was able to mimic the stimulatory effects of poly(I:C) on gammadelta T cells.	Poly I-C	107-116	integrin subunit alpha X	Homo sapiens	50-55
15210743-2	2004	Here, we have compared the role and specificity of TBK1 in the type I IFN response to lipopolysaccharide (LPS), polyI:C, and viral challenge by examining IRF3 nuclear translocation, signal transducer and activator of transcription 1 phosphorylation, and induction of IFN-regulated genes.	Poly I-C	112-119	TANK binding kinase 1	Homo sapiens	51-55
15210743-2	2004	Here, we have compared the role and specificity of TBK1 in the type I IFN response to lipopolysaccharide (LPS), polyI:C, and viral challenge by examining IRF3 nuclear translocation, signal transducer and activator of transcription 1 phosphorylation, and induction of IFN-regulated genes.	Poly I-C	112-119	interferon alpha 1	Homo sapiens	70-73
15210743-3	2004	The LPS and polyI:C-induced IFN responses were abolished and delayed, respectively, in macrophages from mice with a targeted disruption of the TBK1 gene.	Poly I-C	12-19	interferon alpha 1	Homo sapiens	28-31
15210743-3	2004	The LPS and polyI:C-induced IFN responses were abolished and delayed, respectively, in macrophages from mice with a targeted disruption of the TBK1 gene.	Poly I-C	12-19	TANK-binding kinase 1	Mus musculus	143-147
15166448-5	2004	Stimulation of DCs with IFN-alpha/TNF-alpha or polyinosinic-polycytidylic acid (pIC) induced phenotypic maturation with increased MHC and CD80/86 expression, both with mock-treated and infected DCs.	Poly I-C	47-78	CD80 molecule	Homo sapiens	138-142
15166448-5	2004	Stimulation of DCs with IFN-alpha/TNF-alpha or polyinosinic-polycytidylic acid (pIC) induced phenotypic maturation with increased MHC and CD80/86 expression, both with mock-treated and infected DCs.	Poly I-C	80-83	CD80 molecule	Homo sapiens	138-142
15166448-7	2004	Interestingly, similar to macrophages, CSFV did not induce IFN-alpha responses in these DCs and even suppressed pIC-induced IFN-alpha induction.	Poly I-C	112-115	interferon alpha 1	Homo sapiens	124-133
15673163-6	2004	In the present study, we examined the effect of poly IC on the expression of ENA-78 in human umbilical vein endothelial cells (HUVEC).	Poly I-C	48-55	C-X-C motif chemokine ligand 5	Homo sapiens	77-83
15673163-8	2004	Poly IC induced ENA-78 expression in time- and concentration-dependent manners.	Poly I-C	0-7	C-X-C motif chemokine ligand 5	Homo sapiens	16-22
15673163-10	2004	2-Aminopurine, an inhibitor of dsRNA-dependent kinase, suppressed the induction of ENA-78 by poly IC.	Poly I-C	93-100	C-X-C motif chemokine ligand 5	Homo sapiens	83-89
15265658-8	2004	RPE cells treated with poly I:C produced IFN-beta but not IFN-alpha, and this was inhibited by the treatment of RPE cells with anti-TLR 3 antibody.	Poly I-C	23-31	interferon beta 1	Homo sapiens	41-49
15265658-8	2004	RPE cells treated with poly I:C produced IFN-beta but not IFN-alpha, and this was inhibited by the treatment of RPE cells with anti-TLR 3 antibody.	Poly I-C	23-31	toll like receptor 3	Homo sapiens	132-137
15265658-10	2004	Poly I:C treatment of RPE resulted in an increase in the production of IL-6, IL-8, MCP-1, and sICAM-1.	Poly I-C	0-8	interleukin 6	Homo sapiens	71-75
15265658-10	2004	Poly I:C treatment of RPE resulted in an increase in the production of IL-6, IL-8, MCP-1, and sICAM-1.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
15265658-10	2004	Poly I:C treatment of RPE resulted in an increase in the production of IL-6, IL-8, MCP-1, and sICAM-1.	Poly I-C	0-8	C-C motif chemokine ligand 2	Homo sapiens	83-88
15122761-5	2004	An in vitro NK cell cytotoxic assay revealed that hepatocyte toxicity of liver NK cells from both naive and poly I:C-treated mice was inhibited partially by an anti-TRAIL monoclonal antibody (mAb) alone and completely by the combination with anti-Fas ligand (FasL) mAb and a perforin inhibitor, concanamycin A, indicating contribution of TRAIL to NK cell-mediated hepatocyte toxicity.	Poly I-C	108-116	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	165-170
15122761-5	2004	An in vitro NK cell cytotoxic assay revealed that hepatocyte toxicity of liver NK cells from both naive and poly I:C-treated mice was inhibited partially by an anti-TRAIL monoclonal antibody (mAb) alone and completely by the combination with anti-Fas ligand (FasL) mAb and a perforin inhibitor, concanamycin A, indicating contribution of TRAIL to NK cell-mediated hepatocyte toxicity.	Poly I-C	108-116	Fas ligand (TNF superfamily, member 6)	Mus musculus	259-263
15122761-5	2004	An in vitro NK cell cytotoxic assay revealed that hepatocyte toxicity of liver NK cells from both naive and poly I:C-treated mice was inhibited partially by an anti-TRAIL monoclonal antibody (mAb) alone and completely by the combination with anti-Fas ligand (FasL) mAb and a perforin inhibitor, concanamycin A, indicating contribution of TRAIL to NK cell-mediated hepatocyte toxicity.	Poly I-C	108-116	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	338-343
15122761-7	2004	Poly I:C treatment significantly upregulated the expression of Ly-49 receptors on TRAIL(-) NK cells.	Poly I-C	0-8	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	82-87
15063753-3	2004	DsRNA in the form of synthetic polyinosinic-polycytidylic acid (poly IC) induced expression of iNOS and iNOS promoter-driven luciferase activity through activation of nuclear factor (NF)-kappaB and CCAAT/enhancer-binding proteinbeta (C/EBPbeta).	Poly I-C	31-62	nitric oxide synthase 2	Homo sapiens	95-99
15063753-3	2004	DsRNA in the form of synthetic polyinosinic-polycytidylic acid (poly IC) induced expression of iNOS and iNOS promoter-driven luciferase activity through activation of nuclear factor (NF)-kappaB and CCAAT/enhancer-binding proteinbeta (C/EBPbeta).	Poly I-C	31-62	nitric oxide synthase 2	Homo sapiens	104-108
15063753-3	2004	DsRNA in the form of synthetic polyinosinic-polycytidylic acid (poly IC) induced expression of iNOS and iNOS promoter-driven luciferase activity through activation of nuclear factor (NF)-kappaB and CCAAT/enhancer-binding proteinbeta (C/EBPbeta).	Poly I-C	31-62	CCAAT enhancer binding protein beta	Homo sapiens	198-232
15063753-3	2004	DsRNA in the form of synthetic polyinosinic-polycytidylic acid (poly IC) induced expression of iNOS and iNOS promoter-driven luciferase activity through activation of nuclear factor (NF)-kappaB and CCAAT/enhancer-binding proteinbeta (C/EBPbeta).	Poly I-C	31-62	CCAAT enhancer binding protein beta	Homo sapiens	234-243
15063753-3	2004	DsRNA in the form of synthetic polyinosinic-polycytidylic acid (poly IC) induced expression of iNOS and iNOS promoter-driven luciferase activity through activation of nuclear factor (NF)-kappaB and CCAAT/enhancer-binding proteinbeta (C/EBPbeta).	Poly I-C	64-71	nitric oxide synthase 2	Homo sapiens	95-99
15063753-3	2004	DsRNA in the form of synthetic polyinosinic-polycytidylic acid (poly IC) induced expression of iNOS and iNOS promoter-driven luciferase activity through activation of nuclear factor (NF)-kappaB and CCAAT/enhancer-binding proteinbeta (C/EBPbeta).	Poly I-C	64-71	nitric oxide synthase 2	Homo sapiens	104-108
15063753-3	2004	DsRNA in the form of synthetic polyinosinic-polycytidylic acid (poly IC) induced expression of iNOS and iNOS promoter-driven luciferase activity through activation of nuclear factor (NF)-kappaB and CCAAT/enhancer-binding proteinbeta (C/EBPbeta).	Poly I-C	64-71	CCAAT enhancer binding protein beta	Homo sapiens	198-232
15063753-3	2004	DsRNA in the form of synthetic polyinosinic-polycytidylic acid (poly IC) induced expression of iNOS and iNOS promoter-driven luciferase activity through activation of nuclear factor (NF)-kappaB and CCAAT/enhancer-binding proteinbeta (C/EBPbeta).	Poly I-C	64-71	CCAAT enhancer binding protein beta	Homo sapiens	234-243
14698216-7	2004	Zebrafish liver cells produced high levels of Mx mRNA in response to induction by the known IFN-inducer polyinosinic-polycytidylic acid (Poly[I:C]).	Poly I-C	137-145	interferon phi 1	Danio rerio	92-95
15048731-5	2004	Tracheal organ culture for 1 or 4 days with lipopolysaccharide (LPS; TLR2/4 agonist) or polyinosinic polycytidylic acid (poly-I-C; TLR3 agonist) enhanced bradykinin- and [des-Arg(9)]-bradykinin-induced contractions.	Poly I-C	88-119	toll-like receptor 3	Mus musculus	131-135
14688319-2	2004	TLR3 is activated by viral dsRNA and polyinosinic-polycytidylic acid (poly(I:C)), a synthetic mimetic of viral RNA.	Poly I-C	37-68	toll like receptor 3	Homo sapiens	0-4
14688061-0	2004	Polyriboinosinic polyribocytidylic acid [poly(I:C)]/TLR3 signaling allows class I processing of exogenous protein and induction of HIV-specific CD8+ cytotoxic T lymphocytes.	Poly I-C	0-39	toll like receptor 3	Homo sapiens	52-56
14688061-0	2004	Polyriboinosinic polyribocytidylic acid [poly(I:C)]/TLR3 signaling allows class I processing of exogenous protein and induction of HIV-specific CD8+ cytotoxic T lymphocytes.	Poly I-C	0-39	CD8a molecule	Homo sapiens	144-147
14688061-3	2004	Polyriboinosinic polyribocytidylic acid [poly(I:C)], which might reflect a natural genetic product from a variety of viruses during replication, has recently been identified as one of the critical stimuli for TLR3.	Poly I-C	0-39	toll like receptor 3	Homo sapiens	209-213
14688061-3	2004	Polyriboinosinic polyribocytidylic acid [poly(I:C)], which might reflect a natural genetic product from a variety of viruses during replication, has recently been identified as one of the critical stimuli for TLR3.	Poly I-C	41-50	toll like receptor 3	Homo sapiens	209-213
15373970-8	2004	Interestingly, intracellular transduction of poly(I:C) initiates activation of IFN response in a TLR3-independent manner.	Poly I-C	45-54	toll-like receptor 3	Mus musculus	97-101
14982987-2	2004	Instead, TRAF6, TAK1, and TAB2 are recruited to TLR3 on poly(I.C) stimulation.	Poly I-C	56-65	TNF receptor associated factor 6	Homo sapiens	9-14
14982987-2	2004	Instead, TRAF6, TAK1, and TAB2 are recruited to TLR3 on poly(I.C) stimulation.	Poly I-C	56-65	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	16-20
14982987-2	2004	Instead, TRAF6, TAK1, and TAB2 are recruited to TLR3 on poly(I.C) stimulation.	Poly I-C	56-65	toll like receptor 3	Homo sapiens	48-52
14982987-11	2004	Furthermore, whereas poly(I.C)-induced NF-kappaB activation is completely abolished inTRAF6-/- MEFs, the signal-induced activation of IRF3 is TRAF6 independent.	Poly I-C	21-30	nuclear factor kappa B subunit 1	Homo sapiens	39-48
14982987-11	2004	Furthermore, whereas poly(I.C)-induced NF-kappaB activation is completely abolished inTRAF6-/- MEFs, the signal-induced activation of IRF3 is TRAF6 independent.	Poly I-C	21-30	TNF receptor associated factor 6	Homo sapiens	86-91
14991609-5	2004	TLR-9 stimulation by CpG DNA induced the expression of all IFN-alpha, -beta, -omicron and -lambda subtypes in pDC, whereas TLR-4 stimulation by LPS, or TLR-3 stimulation by poly I:C, induced only IFN-beta and IFN-lambda gene expression in MDDC.	Poly I-C	173-181	toll like receptor 9	Homo sapiens	0-5
14991609-5	2004	TLR-9 stimulation by CpG DNA induced the expression of all IFN-alpha, -beta, -omicron and -lambda subtypes in pDC, whereas TLR-4 stimulation by LPS, or TLR-3 stimulation by poly I:C, induced only IFN-beta and IFN-lambda gene expression in MDDC.	Poly I-C	173-181	toll like receptor 4	Homo sapiens	123-128
14991609-5	2004	TLR-9 stimulation by CpG DNA induced the expression of all IFN-alpha, -beta, -omicron and -lambda subtypes in pDC, whereas TLR-4 stimulation by LPS, or TLR-3 stimulation by poly I:C, induced only IFN-beta and IFN-lambda gene expression in MDDC.	Poly I-C	173-181	toll like receptor 3	Homo sapiens	152-157
14688319-2	2004	TLR3 is activated by viral dsRNA and polyinosinic-polycytidylic acid (poly(I:C)), a synthetic mimetic of viral RNA.	Poly I-C	70-79	toll like receptor 3	Homo sapiens	0-4
14688319-5	2004	Poly(I:C) stimulation also leads to up-regulation of activation marker CD69 on NK cells.	Poly I-C	0-8	CD69 molecule	Homo sapiens	71-75
12960343-6	2003	iDCs produced IL-12p70 and IFN-alpha and -beta in response to poly(I:C).	Poly I-C	62-70	interferon alpha 1	Homo sapiens	27-36
14599853-4	2003	Moreover, Poly (I:C)-induced IFN-alpha production was found to be significantly impaired in cord blood.	Poly I-C	10-20	interferon alpha 1	Homo sapiens	29-38
14575692-1	2003	PolyI:C, a synthetic double-stranded (ds)RNA, and viruses act on cells to induce IFN-beta which is a key molecule for anti-viral response.	Poly I-C	0-7	interferon beta 1	Homo sapiens	81-89
12888903-5	2003	Transfer by transfection of poly(I:C), an analogue of double stranded RNA (dsRNA), into the BHK cells induced also by itself the production of IFN-alpha.	Poly I-C	28-36	interferon alpha 1	Homo sapiens	143-152
12845500-7	2003	In the spleen and head kidney, expression of IL-12 p35 was induced by polyriboinosinic polyribocytidylic acid [poly(I:C)] and not by lipopolysaccharide (LPS), while expression of IL-12 p40 was constitutive and unresponsive to both poly(I:C) and LPS.	Poly I-C	70-109	interleukin 12A	Homo sapiens	51-54
12845500-7	2003	In the spleen and head kidney, expression of IL-12 p35 was induced by polyriboinosinic polyribocytidylic acid [poly(I:C)] and not by lipopolysaccharide (LPS), while expression of IL-12 p40 was constitutive and unresponsive to both poly(I:C) and LPS.	Poly I-C	111-120	interleukin 12A	Homo sapiens	51-54
12845500-7	2003	In the spleen and head kidney, expression of IL-12 p35 was induced by polyriboinosinic polyribocytidylic acid [poly(I:C)] and not by lipopolysaccharide (LPS), while expression of IL-12 p40 was constitutive and unresponsive to both poly(I:C) and LPS.	Poly I-C	231-240	interleukin 12A	Homo sapiens	51-54
12697896-2	2003	We find that PD-L1 is highly expressed on inflammatory macrophages as compared with resident peritoneal macrophages but can be induced on resident macrophages by classical activation stimuli such as lipopolysaccharide, IFN-gamma, and polyinosinic-polycytidylic acid.	Poly I-C	234-265	CD274 molecule	Homo sapiens	13-18
12609980-0	2003	Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .	Poly I-C	0-9	toll like receptor 3	Homo sapiens	18-38
12609980-0	2003	Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .	Poly I-C	0-9	toll like receptor 3	Homo sapiens	40-44
12609980-0	2003	Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .	Poly I-C	0-9	nuclear factor kappa B subunit 1	Homo sapiens	69-78
12609980-0	2003	Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .	Poly I-C	0-9	interleukin 1 receptor associated kinase 1	Homo sapiens	150-154
12609980-0	2003	Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .	Poly I-C	0-9	toll like receptor 3	Homo sapiens	211-215
12609980-0	2003	Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .	Poly I-C	0-9	TNF receptor associated factor 6	Homo sapiens	216-221
12609980-0	2003	Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .	Poly I-C	0-9	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	222-226
12413939-7	2002	In addition, leptin treatment increased the basal or synergistically enhanced IL-15- and poly I:C-induced specific lysis of splenocytes in normal littermates but not in db/db mice.	Poly I-C	89-97	leptin	Mus musculus	13-19
12519390-4	2003	The addition of TNF-alpha, polyriboinosinic polyribocytidylic acid (Poly(I:C)) and LPS to autologous DCs resulted in the emergence of only a small percentage of CD83+ DCs, IFN-alpha having no demonstrable effect.	Poly I-C	27-66	CD83 molecule	Homo sapiens	161-165
12525633-5	2003	Treatment with the known IFN inducer polyinosinic acid-polycytidylic acid (poly[I]-poly[C]) resulted in an increase in zfIFN mRNA transcripts.	Poly I-C	37-73	interferon phi 1	Danio rerio	25-28
12525633-5	2003	Treatment with the known IFN inducer polyinosinic acid-polycytidylic acid (poly[I]-poly[C]) resulted in an increase in zfIFN mRNA transcripts.	Poly I-C	37-73	interferon phi 1	Danio rerio	119-124
12149218-5	2002	Costimulation with PGE2 enhanced the expression of the CCL19/CCL21 receptor CCR7 on the cell surface of MoDCs when they were matured with soluble CD40 ligand or proinflammatory cytokines, but did not affect CCR7 expression of polyI:C-stimulated MoDCs.	Poly I-C	226-233	C-C motif chemokine ligand 19	Homo sapiens	55-60
12149218-5	2002	Costimulation with PGE2 enhanced the expression of the CCL19/CCL21 receptor CCR7 on the cell surface of MoDCs when they were matured with soluble CD40 ligand or proinflammatory cytokines, but did not affect CCR7 expression of polyI:C-stimulated MoDCs.	Poly I-C	226-233	C-C motif chemokine ligand 21	Homo sapiens	61-66
12149218-5	2002	Costimulation with PGE2 enhanced the expression of the CCL19/CCL21 receptor CCR7 on the cell surface of MoDCs when they were matured with soluble CD40 ligand or proinflammatory cytokines, but did not affect CCR7 expression of polyI:C-stimulated MoDCs.	Poly I-C	226-233	C-C motif chemokine receptor 7	Homo sapiens	76-80
12096926-7	2002	When melanocytes and melanoma cells were treated with a potent IFN inducer, polyinosinic:polycytidylic acid (poly I:C), the mRNA expression of both IFN-alpha and IFN-beta was significantly upregulated.	Poly I-C	109-117	interferon beta 1	Homo sapiens	162-170
12100019-4	2002	Poly I:C induced chronic severe pancreatitis in all the MRL/+ mice and to a lesser extent in the MRL/lpr mice by 18 weeks of age.	Poly I-C	0-8	Fas (TNF receptor superfamily member 6)	Mus musculus	101-104
12021178-1	2002	We previously reported that reduction of autocrine IGF-I by polyinosinic-polycytidylic acid [poly(IC)] was permissive for the poly(IC)-mediated decrease in C6 rat glioma cell number.	Poly I-C	60-91	insulin-like growth factor 1	Rattus norvegicus	51-56
12021178-1	2002	We previously reported that reduction of autocrine IGF-I by polyinosinic-polycytidylic acid [poly(IC)] was permissive for the poly(IC)-mediated decrease in C6 rat glioma cell number.	Poly I-C	93-101	insulin-like growth factor 1	Rattus norvegicus	51-56
12021178-1	2002	We previously reported that reduction of autocrine IGF-I by polyinosinic-polycytidylic acid [poly(IC)] was permissive for the poly(IC)-mediated decrease in C6 rat glioma cell number.	Poly I-C	126-134	insulin-like growth factor 1	Rattus norvegicus	51-56
12021178-4	2002	Inhibition of protein kinase R (PKR) activation partially prevented the poly(IC)-mediated cytostasis of C6 cells.	Poly I-C	72-80	eukaryotic translation initiation factor 2-alpha kinase 2	Rattus norvegicus	14-30
12021178-4	2002	Inhibition of protein kinase R (PKR) activation partially prevented the poly(IC)-mediated cytostasis of C6 cells.	Poly I-C	72-80	eukaryotic translation initiation factor 2-alpha kinase 2	Rattus norvegicus	32-35
12021178-7	2002	We conclude that poly(IC) induces IFN, which mediates the cytostatic effect of poly(IC) on C6 cells at least in part through PKR.	Poly I-C	17-25	eukaryotic translation initiation factor 2-alpha kinase 2	Rattus norvegicus	125-128
12021178-7	2002	We conclude that poly(IC) induces IFN, which mediates the cytostatic effect of poly(IC) on C6 cells at least in part through PKR.	Poly I-C	79-87	eukaryotic translation initiation factor 2-alpha kinase 2	Rattus norvegicus	125-128
12194451-8	2002	In rainbow trout gonad (RTG) cells, IRF-1 is expressed constitutively and up-regulated by poly I:C but not by LPS.	Poly I-C	90-98	interferon regulatory factor 1b	Oncorhynchus mykiss	36-41
12096926-7	2002	When melanocytes and melanoma cells were treated with a potent IFN inducer, polyinosinic:polycytidylic acid (poly I:C), the mRNA expression of both IFN-alpha and IFN-beta was significantly upregulated.	Poly I-C	109-117	interferon alpha 1	Homo sapiens	63-66
12096926-7	2002	When melanocytes and melanoma cells were treated with a potent IFN inducer, polyinosinic:polycytidylic acid (poly I:C), the mRNA expression of both IFN-alpha and IFN-beta was significantly upregulated.	Poly I-C	109-117	interferon alpha 1	Homo sapiens	148-157
12096926-8	2002	Poly I:C was not able to induce melanocytes or melanoma cells to produce detectable amounts of IFN-alpha protein, but able to induce a significant amount of IFN-beta in melanocytes and two of the melanoma cell lines: MMAc and VMRC-MELG.	Poly I-C	0-8	interferon beta 1	Homo sapiens	157-165
11823500-6	2002	Poly(I:C) (dsRNA, mimic for virus) induced the development of extremely potent Th1-inducing DC1, surprisingly, without an enhanced IL-12 production.	Poly I-C	0-8	negative elongation factor complex member C/D	Homo sapiens	79-82
11828366-7	2002	Monocyte-derived dendritic cells harbored HCR, and expression was enhanced following stimulation by lipopolysaccharides, poly (I:C), IFN-gamma or CD40L.	Poly I-C	121-131	C-C motif chemokine receptor like 2	Homo sapiens	42-45
11602716-6	2001	This loss of NKT cells was independent of gamma interferon (IFN-gamma) and interleukin 12 (IL-12) production, but did occur in mice treated with poly(I-C), a classical inducer of IFN-alpha/beta.	Poly I-C	145-153	interferon alpha	Mus musculus	179-188
11602647-4	2001	Surprisingly, IL-15Ralpha(-/-) CD8(+) T cells proliferate in response to poly I:C when adoptively transferred into normal mice, and normal CD8(+) T cells fail to proliferate in IL-15Ralpha(-/-) mice.	Poly I-C	73-81	interleukin 15 receptor, alpha chain	Mus musculus	14-25
11607032-7	2001	Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature.	Poly I-C	10-18	MYD88 innate immune signal transduction adaptor	Homo sapiens	116-121
11356709-3	2001	We presently investigated whether the viral replicative intermediate double stranded RNA [here used as synthetic polyinosinic-polycytidylic acid (PIC)] modifies the effects of IL-1beta and IFN-gamma on gene expression and viability of rat pancreatic beta-cells.	Poly I-C	146-149	interleukin 1 beta	Rattus norvegicus	176-184
11544303-2	2001	In this study, we present evidence that signaling lymphocytic activation molecule (SLAM), a molecule first identified in activated T and B cells, is strongly up-regulated in DC activated through CD40, as well as in response to inflammatory stimuli, including polyinosinic polycytidylic acid and LPS.	Poly I-C	259-290	signaling lymphocytic activation molecule family member 1	Homo sapiens	40-81
11544303-2	2001	In this study, we present evidence that signaling lymphocytic activation molecule (SLAM), a molecule first identified in activated T and B cells, is strongly up-regulated in DC activated through CD40, as well as in response to inflammatory stimuli, including polyinosinic polycytidylic acid and LPS.	Poly I-C	259-290	signaling lymphocytic activation molecule family member 1	Homo sapiens	83-87
11418248-7	2001	The Oasl5 mRNA expression in ES cells was elevated 5-fold after treatment with IFN and about 2-fold in the brain when stimulated with IFN inducer, polyinosinic-polycytidylic acid (poly[I:C]).	Poly I-C	147-178	2'-5' oligoadenylate synthetase 1C	Mus musculus	4-9
11418248-7	2001	The Oasl5 mRNA expression in ES cells was elevated 5-fold after treatment with IFN and about 2-fold in the brain when stimulated with IFN inducer, polyinosinic-polycytidylic acid (poly[I:C]).	Poly I-C	180-188	2'-5' oligoadenylate synthetase 1C	Mus musculus	4-9
11563672-5	2001	However, if cells are activated by the lectins PWM or ConA or by double-stranded RNA (polyinosinic-polycytidylic acid, pI:C), normal MAC maturation is suppressed: MO stay small and do not acquire MAC maturation-associated surface molecules like carboxypeptidase M (CPM, determined by antibody MAX.1) or CD84 (determined by antibody MAX.3).	Poly I-C	86-117	CD84 molecule	Homo sapiens	303-307
11356709-12	2001	The transcription factor nuclear factor-kappaB is required for PIC-induced iNOS expression.	Poly I-C	63-66	nitric oxide synthase 2	Rattus norvegicus	75-79
11356709-13	2001	PIC has an additive effect on cytokine-induced beta-cell death by both NO-dependent (in the case of IL-1beta) and NO-independent (in the case of IFN-gamma) mechanisms.	Poly I-C	0-3	interleukin 1 beta	Rattus norvegicus	100-108
11356709-13	2001	PIC has an additive effect on cytokine-induced beta-cell death by both NO-dependent (in the case of IL-1beta) and NO-independent (in the case of IFN-gamma) mechanisms.	Poly I-C	0-3	interferon gamma	Rattus norvegicus	145-154
11108714-4	2001	In combination, synthetic dsRNA (polyinosinic-polycytidylic acid, poly(I-C)) and interferon (IFN)-gamma stimulate inducible nitric-oxide synthase (iNOS) expression, inhibit insulin secretion, and induce islet degeneration.	Poly I-C	33-64	nitric oxide synthase 2	Homo sapiens	114-145
11108714-4	2001	In combination, synthetic dsRNA (polyinosinic-polycytidylic acid, poly(I-C)) and interferon (IFN)-gamma stimulate inducible nitric-oxide synthase (iNOS) expression, inhibit insulin secretion, and induce islet degeneration.	Poly I-C	33-64	nitric oxide synthase 2	Homo sapiens	147-151
11108714-4	2001	In combination, synthetic dsRNA (polyinosinic-polycytidylic acid, poly(I-C)) and interferon (IFN)-gamma stimulate inducible nitric-oxide synthase (iNOS) expression, inhibit insulin secretion, and induce islet degeneration.	Poly I-C	66-75	nitric oxide synthase 2	Homo sapiens	114-145
11108714-4	2001	In combination, synthetic dsRNA (polyinosinic-polycytidylic acid, poly(I-C)) and interferon (IFN)-gamma stimulate inducible nitric-oxide synthase (iNOS) expression, inhibit insulin secretion, and induce islet degeneration.	Poly I-C	66-75	nitric oxide synthase 2	Homo sapiens	147-151
11108714-9	2001	In addition, poly(I-C) + IFN-gamma-induced iNOS expression and nitric oxide production by human islets are prevented by interleukin-1 receptor antagonist protein, indicating that human islets respond to dsRNA and IFN-gamma in a manner similar to rat islets.	Poly I-C	13-21	interferon gamma	Homo sapiens	25-34
11108714-9	2001	In addition, poly(I-C) + IFN-gamma-induced iNOS expression and nitric oxide production by human islets are prevented by interleukin-1 receptor antagonist protein, indicating that human islets respond to dsRNA and IFN-gamma in a manner similar to rat islets.	Poly I-C	13-21	nitric oxide synthase 2	Homo sapiens	43-47
11108714-9	2001	In addition, poly(I-C) + IFN-gamma-induced iNOS expression and nitric oxide production by human islets are prevented by interleukin-1 receptor antagonist protein, indicating that human islets respond to dsRNA and IFN-gamma in a manner similar to rat islets.	Poly I-C	13-21	interleukin 1 receptor antagonist	Homo sapiens	120-161
11108714-9	2001	In addition, poly(I-C) + IFN-gamma-induced iNOS expression and nitric oxide production by human islets are prevented by interleukin-1 receptor antagonist protein, indicating that human islets respond to dsRNA and IFN-gamma in a manner similar to rat islets.	Poly I-C	13-21	interferon gamma	Homo sapiens	213-222
11342002-3	2001	ApoE potentiates NO production in immune activated RAW cells in combination with lipopolysaccharide or polyinosinic:polycytidylic acid (PIC), agents known to induce expression of inducible nitric oxide synthase mRNA and protein.	Poly I-C	103-134	apolipoprotein E	Mus musculus	0-4
11160284-6	2001	In contrast, a synthetic dsRNA, polyinosinic polycytidylic-acid, induced CD11c(+) DC, but not pre-DC2 or monocytes, to produce IFN-alphabeta.	Poly I-C	32-63	integrin subunit alpha X	Homo sapiens	73-78
11160284-6	2001	In contrast, a synthetic dsRNA, polyinosinic polycytidylic-acid, induced CD11c(+) DC, but not pre-DC2 or monocytes, to produce IFN-alphabeta.	Poly I-C	32-63	interferon alpha 8	Homo sapiens	127-140
11342002-3	2001	ApoE potentiates NO production in immune activated RAW cells in combination with lipopolysaccharide or polyinosinic:polycytidylic acid (PIC), agents known to induce expression of inducible nitric oxide synthase mRNA and protein.	Poly I-C	103-134	nitric oxide synthase 2, inducible	Mus musculus	179-210
11342002-3	2001	ApoE potentiates NO production in immune activated RAW cells in combination with lipopolysaccharide or polyinosinic:polycytidylic acid (PIC), agents known to induce expression of inducible nitric oxide synthase mRNA and protein.	Poly I-C	136-139	apolipoprotein E	Mus musculus	0-4
11342002-3	2001	ApoE potentiates NO production in immune activated RAW cells in combination with lipopolysaccharide or polyinosinic:polycytidylic acid (PIC), agents known to induce expression of inducible nitric oxide synthase mRNA and protein.	Poly I-C	136-139	nitric oxide synthase 2, inducible	Mus musculus	179-210
11269746-3	2001	We have combined in the present study the NK-enhancing properties of IFN (Poly I:C-induced) and TNF-alpha by giving Poly I:C to leukemic mice for 8 days after irradiation and SBMT, concomitant with TNF-alpha during the first 4 days immediately after SBMT.	Poly I-C	74-82	tumor necrosis factor	Mus musculus	198-207
11272138-5	2001	Treatment of rat and human islets with dsRNA in the form of polyinosinic-polycytidylic acid (poly IC) and IFN-gamma resulted in iNOS expression and nitric oxide production.	Poly I-C	60-91	nitric oxide synthase 2	Rattus norvegicus	128-132
11269746-6	2001	RESULTS: The data reveal that TNF-alpha, added to the Poly I:C administration protocol, significantly boosted NK cell numbers 2.4-fold over that achieved by Poly I:C alone.	Poly I-C	54-62	tumor necrosis factor	Mus musculus	30-39
11269746-6	2001	RESULTS: The data reveal that TNF-alpha, added to the Poly I:C administration protocol, significantly boosted NK cell numbers 2.4-fold over that achieved by Poly I:C alone.	Poly I-C	157-165	tumor necrosis factor	Mus musculus	30-39
11093145-5	2000	In addition, poly I.C, a double-stranded RNA analog that mimics viral infection, also synergized with CD40L to stimulate DC to secrete high levels of IL-12 and IL-10.	Poly I-C	13-21	CD40 ligand	Homo sapiens	102-107
11093145-5	2000	In addition, poly I.C, a double-stranded RNA analog that mimics viral infection, also synergized with CD40L to stimulate DC to secrete high levels of IL-12 and IL-10.	Poly I-C	13-21	interleukin 10	Homo sapiens	160-165
11043581-5	2000	Treatment with polyinosinic-polycytidylic acid to induce expression of Cre resulted in complete disruption of the Arnt gene and loss of ARNT messenger RNA (mRNA) expression in liver.	Poly I-C	15-46	aryl hydrocarbon receptor nuclear translocator	Mus musculus	114-118
11041858-6	2000	Both mutants decreased eIF2alpha phosphorylation occurring in hemin and poly(IC)-treated reticulocyte lysates due to the activation of double-stranded RNA-dependent protein kinase (PKR).	Poly I-C	72-80	eukaryotic translation initiation factor 2A	Oryctolagus cuniculus	23-32
11043581-5	2000	Treatment with polyinosinic-polycytidylic acid to induce expression of Cre resulted in complete disruption of the Arnt gene and loss of ARNT messenger RNA (mRNA) expression in liver.	Poly I-C	15-46	aryl hydrocarbon receptor nuclear translocator	Mus musculus	136-140
10384099-5	1999	Poly(I:C)-treated DC show a mature phenotype with high expression levels of HLA-DR, CD86, and the DC maturation marker CD83.	Poly I-C	0-9	CD86 molecule	Homo sapiens	84-88
10756029-2	2000	The present study was done to identify the step(s) in HBV replication that is affected by this cytokine in transgenic mice treated with the IFN-alpha/beta inducer polyinosinic-polycytidylic acid [poly(I-C)].	Poly I-C	163-194	interferon alpha	Mus musculus	140-149
10823866-12	2000	The effect of expression of HCV proteins on PKR activity was assayed in a reporter assay and by direct analysis of the in vivo phosphorylation of eIF2alpha after treatment of cells with poly(I)-poly(C).	Poly I-C	186-200	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	44-47
10946161-3	2000	Treatment of mice with poly I:C upregulated IFN-alpha and granzyme B, but not perforin, in the spleen.	Poly I-C	23-31	interferon alpha	Mus musculus	44-53
10946161-3	2000	Treatment of mice with poly I:C upregulated IFN-alpha and granzyme B, but not perforin, in the spleen.	Poly I-C	23-31	granzyme B	Mus musculus	58-68
10723127-3	2000	To define how PKR mediates NF-kappa B activation by dsRNA, we have used two different approaches, one based on expression of PKR by a vaccinia virus (VV) recombinant and the other based on induction of endogenous PKR by poly I:C (pIC) treatment.	Poly I-C	220-228	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	14-17
10523619-6	1999	In a classical in vitro kinase assay, addition of either poly(I)-poly(C) or an in vitro-transcribed D-HIT homolog stimulated the autophosphorylation activity of PKR from IFN-alpha-treated cells in both EBV-positive and EBV-negative B lymphocytes.	Poly I-C	57-72	interferon alpha 1	Homo sapiens	170-179
10521464-6	1999	Although both vascular cell adhesion molecule-1 mRNA and protein increased 3-4-fold in poly(I.C)-treated M-SMC cultures, U937 cell adhesion was not blocked by an anti-vascular cell adhesion molecule-1 monoclonal antibody.	Poly I-C	87-96	vascular cell adhesion molecule 1	Homo sapiens	14-47
10521464-9	1999	In addition, pretreatment of mononuclear cells with a blocking anti-CD44 antibody, greatly decreased adhesion to poly(I.C)-treated M-SMCs.	Poly I-C	113-122	CD44 molecule (Indian blood group)	Homo sapiens	68-72
10384099-5	1999	Poly(I:C)-treated DC show a mature phenotype with high expression levels of HLA-DR, CD86, and the DC maturation marker CD83.	Poly I-C	0-9	CD83 molecule	Homo sapiens	119-123
10384099-7	1999	In contrast to untreated DC, poly(I:C)-treated DC down-regulate pinocytosis, produce high levels of IL-12 and low levels of IL-10, induce strong T cell proliferation in a primary allo MLR, and effectively present peptide Ags to HLA class I-restricted CTL.	Poly I-C	29-38	interleukin 10	Homo sapiens	124-129
10212230-2	1999	In this study, the effects of the viral replicative intermediate, double-stranded RNA (dsRNA) (in the form of synthetic polyinosinic-polycytidylic acid (poly IC)) on islet expression of inducible nitric oxide synthase (iNOS), production of nitric oxide, and islet function and viability were investigated.	Poly I-C	120-151	nitric oxide synthase 2	Rattus norvegicus	219-223
9614147-7	1998	The effects of poly(I-C) on iNOS expression appear to be cell-type specific.	Poly I-C	15-23	nitric oxide synthase 2, inducible	Mus musculus	28-32
9673429-11	1998	Polyriboinosinic-polyribocytidylic acid caused a significant decrease in free and total acid and pepsin and an increase in mucin content in Shay (pylorus-ligated) rat.	Poly I-C	0-39	solute carrier family 13 member 2	Rattus norvegicus	123-128
9614147-2	1998	Individually, poly(I-C), interferon-gamma (IFN-gamma), and lipopolysaccharide (LPS) stimulate nitrite production and iNOS expression by RAW 264.7 cells.	Poly I-C	14-22	nitric oxide synthase 2, inducible	Mus musculus	117-121
9614147-9	1998	In addition, we show that the combination of poly(I-C) + IFN-gamma stimulates iNOS expression, nitrite production, IkappaB degradation, and the release of IL-1 by primary mouse macrophages, and these effects are prevented by pyrrolidinedithiocarbamate.	Poly I-C	45-54	nitric oxide synthase 2, inducible	Mus musculus	78-82
9614147-4	1998	These results suggest that poly(I-C) and LPS may stimulate iNOS expression by similar signaling pathways, which may be independent of pathways activated by IFN-gamma.	Poly I-C	27-36	nitric oxide synthase 2, inducible	Mus musculus	59-63
9614147-9	1998	In addition, we show that the combination of poly(I-C) + IFN-gamma stimulates iNOS expression, nitrite production, IkappaB degradation, and the release of IL-1 by primary mouse macrophages, and these effects are prevented by pyrrolidinedithiocarbamate.	Poly I-C	45-54	interleukin 1 complex	Mus musculus	155-159
9789120-1	1998	Interferon-gamma and interferon inducers such as polyinosinic-polycytidylic acid (poly I:C) promote natural-killer (NK)-cell-mediated killing of a wide range of tumor cells both in vitro and in vivo.	Poly I-C	49-80	interferon gamma	Mus musculus	0-16
9620680-1	1998	Proliferation of memory-phenotype (CD44hi) CD8+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I-inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent.	Poly I-C	201-209	CD8a molecule	Homo sapiens	43-46
9789120-1	1998	Interferon-gamma and interferon inducers such as polyinosinic-polycytidylic acid (poly I:C) promote natural-killer (NK)-cell-mediated killing of a wide range of tumor cells both in vitro and in vivo.	Poly I-C	82-90	interferon gamma	Mus musculus	0-16
9388488-4	1997	ApoE treatment released 68% more NO than cells treated with poly I:C alone and almost threefold more NO than unprimed cells.	Poly I-C	60-68	apolipoprotein E	Homo sapiens	0-4
9366398-2	1997	For example, injection of poly (I:C) can alter specific Ab responses, which is attributable to the production of IFN-gamma by NK cells.	Poly I-C	26-36	interferon gamma	Mus musculus	113-122
22358899-1	1997	Two hundreds species of marine algae were investigated for in vitro promoting activity of human interferon beta (IFN-beta) production by poly(I:C)-induced human osteosarcoma cell line, MG-63.	Poly I-C	137-146	interferon beta 1	Homo sapiens	96-111
9374789-5	1997	Poly(I-C)-induced monocytic cell adhesion to primary EC was concentration-dependently inhibited by 40-74% by the nitric oxide synthase (NOS) inhibitor NG-methyl-L-arginine (L-NMA), as well as three other NOS inhibitors, without significantly affecting interleukin-1 beta-induced adhesion.	Poly I-C	0-8	nitric oxide synthase 2	Homo sapiens	113-134
9374789-5	1997	Poly(I-C)-induced monocytic cell adhesion to primary EC was concentration-dependently inhibited by 40-74% by the nitric oxide synthase (NOS) inhibitor NG-methyl-L-arginine (L-NMA), as well as three other NOS inhibitors, without significantly affecting interleukin-1 beta-induced adhesion.	Poly I-C	0-8	interleukin 1 beta	Homo sapiens	252-270
9374789-6	1997	L-NMA inhibited poly(I-C)-induced surface expression of E-selectin and VCAM-1 by 25 and 45%, respectively, and mRNA levels of E-selectin and VCAM-1 by 62 and 74%, respectively.	Poly I-C	16-25	selectin E	Homo sapiens	56-66
9374789-6	1997	L-NMA inhibited poly(I-C)-induced surface expression of E-selectin and VCAM-1 by 25 and 45%, respectively, and mRNA levels of E-selectin and VCAM-1 by 62 and 74%, respectively.	Poly I-C	16-25	vascular cell adhesion molecule 1	Homo sapiens	71-77
9374789-7	1997	Primary EC transiently transfected with a plasmid containing an E-selectin promoter-driven luciferase reporter gene showed that L-NMA treatment reduced poly(I-C)-induced E-selectin promoter activity to basal levels.	Poly I-C	152-161	selectin E	Homo sapiens	64-74
9374789-7	1997	Primary EC transiently transfected with a plasmid containing an E-selectin promoter-driven luciferase reporter gene showed that L-NMA treatment reduced poly(I-C)-induced E-selectin promoter activity to basal levels.	Poly I-C	152-161	selectin E	Homo sapiens	170-180
9374789-8	1997	Electrophoretic mobility shift analysis indicated that poly(I-C)-induced nuclear factor-kappa B (NF-kappa B) binding to a radiolabeled oligonucleotide corresponding to the consensus NF-kappa B binding domain of the E-selectin promoter was decreased by L-NMA pretreatment.	Poly I-C	55-64	nuclear factor kappa B subunit 1	Homo sapiens	97-107
9374789-8	1997	Electrophoretic mobility shift analysis indicated that poly(I-C)-induced nuclear factor-kappa B (NF-kappa B) binding to a radiolabeled oligonucleotide corresponding to the consensus NF-kappa B binding domain of the E-selectin promoter was decreased by L-NMA pretreatment.	Poly I-C	55-64	nuclear factor kappa B subunit 1	Homo sapiens	182-192
9374789-8	1997	Electrophoretic mobility shift analysis indicated that poly(I-C)-induced nuclear factor-kappa B (NF-kappa B) binding to a radiolabeled oligonucleotide corresponding to the consensus NF-kappa B binding domain of the E-selectin promoter was decreased by L-NMA pretreatment.	Poly I-C	55-64	selectin E	Homo sapiens	215-225
22358899-1	1997	Two hundreds species of marine algae were investigated for in vitro promoting activity of human interferon beta (IFN-beta) production by poly(I:C)-induced human osteosarcoma cell line, MG-63.	Poly I-C	137-146	interferon beta 1	Homo sapiens	113-121
9378988-2	1997	We show in this study that IFN-gamma treatment down-regulates the induction by a viral mimetic, polyinosinic-polycytidylic acid (poly(I:C)), of the endothelial cell-specific leukocyte adhesion protein, E-selectin.	Poly I-C	96-127	interferon gamma	Homo sapiens	27-36
9378988-2	1997	We show in this study that IFN-gamma treatment down-regulates the induction by a viral mimetic, polyinosinic-polycytidylic acid (poly(I:C)), of the endothelial cell-specific leukocyte adhesion protein, E-selectin.	Poly I-C	96-127	selectin E	Homo sapiens	202-212
9378988-5	1997	Poly(I:C)-induced E-selectin mRNA t1/2 was reduced slightly by IFN-gamma treatment, while the message for VCAM-1 was stabilized.	Poly I-C	0-9	selectin E	Homo sapiens	18-28
9378988-5	1997	Poly(I:C)-induced E-selectin mRNA t1/2 was reduced slightly by IFN-gamma treatment, while the message for VCAM-1 was stabilized.	Poly I-C	0-9	interferon gamma	Homo sapiens	63-72
9378988-7	1997	Poly(I:C)-induced nuclear factor-kappa B activation following IFN-gamma pretreatment was unaffected, as shown by electrophoretic mobility shift analysis.	Poly I-C	0-9	interferon gamma	Homo sapiens	62-71
9181462-0	1997	Chemotherapeutic purine analogs alter the level of interferon-beta mRNA induced by poly I-poly C in cultured osteosarcoma cells.	Poly I-C	83-96	interferon beta 1	Homo sapiens	51-66
9220587-4	1997	Poly I:C injections induced local production of interferon-alpha (IFN-alpha) as well as tumor necrosis factor (TNF) in the TCF but kinetic differences in the production of the cytokines were noted.	Poly I-C	0-8	interferon-alpha-14	Sus scrofa	48-64
9220587-4	1997	Poly I:C injections induced local production of interferon-alpha (IFN-alpha) as well as tumor necrosis factor (TNF) in the TCF but kinetic differences in the production of the cytokines were noted.	Poly I-C	0-8	interferon-alpha-14	Sus scrofa	66-75
9220587-4	1997	Poly I:C injections induced local production of interferon-alpha (IFN-alpha) as well as tumor necrosis factor (TNF) in the TCF but kinetic differences in the production of the cytokines were noted.	Poly I-C	0-8	tumor necrosis factor	Sus scrofa	88-109
9220587-4	1997	Poly I:C injections induced local production of interferon-alpha (IFN-alpha) as well as tumor necrosis factor (TNF) in the TCF but kinetic differences in the production of the cytokines were noted.	Poly I-C	0-8	tumor necrosis factor	Sus scrofa	111-114
9181462-5	1997	Northern blot analysis showed a dose-dependent inhibition of IFN-B mRNA accumulation in response to a known inducer (Poly I-Poly C) all three purine analogs.	Poly I-C	117-130	interferon beta 1	Homo sapiens	61-66
8816415-2	1996	Conditions of systemic IFN-beta expression elicited by polyinosinic-polycytidylic acid (poly(I:C)) treatment or IFN-alpha beta production during lymphocytic choriomeningitis virus or murine cytomegalovirus infections resulted in profound splenic histologic changes, with relocalization of nucleated cells from red to white pulp regions.	Poly I-C	55-86	interferon alpha 1	Homo sapiens	23-26
8841427-0	1996	Enhanced biosynthesis of extracellular matrix proteins and TGF-beta 1 by polyinosinic-polycytidylic acid during cutaneous wound healing in vivo.	Poly I-C	73-104	transforming growth factor, beta 1	Rattus norvegicus	59-69
8841427-7	1996	Immunofluorescence studies showed increased expression of adhesion molecules that includes ICAM-1 (intercellular adhesion molecule-1;CD54) and VCAM-1 (vascular cell adhesion molecule; CD 106) in poly I:C-treated wounds as compared to untreated control.	Poly I-C	195-203	intercellular adhesion molecule 1	Rattus norvegicus	91-97
8841427-7	1996	Immunofluorescence studies showed increased expression of adhesion molecules that includes ICAM-1 (intercellular adhesion molecule-1;CD54) and VCAM-1 (vascular cell adhesion molecule; CD 106) in poly I:C-treated wounds as compared to untreated control.	Poly I-C	195-203	intercellular adhesion molecule 1	Rattus norvegicus	99-137
8841427-7	1996	Immunofluorescence studies showed increased expression of adhesion molecules that includes ICAM-1 (intercellular adhesion molecule-1;CD54) and VCAM-1 (vascular cell adhesion molecule; CD 106) in poly I:C-treated wounds as compared to untreated control.	Poly I-C	195-203	vascular cell adhesion molecule 1	Rattus norvegicus	143-149
8841427-8	1996	Poly I:C treatment resulted in an increase in the mRNA levels of collagen type 1 (alpha), collagen III, laminin B1, and transforming growth factor-beta 1(TGF-beta 1) in wounds compared to untreated wounds as demonstrated by in situ hybridization and PCR analysis.	Poly I-C	0-8	transforming growth factor, beta 1	Rattus norvegicus	104-153
8841427-8	1996	Poly I:C treatment resulted in an increase in the mRNA levels of collagen type 1 (alpha), collagen III, laminin B1, and transforming growth factor-beta 1(TGF-beta 1) in wounds compared to untreated wounds as demonstrated by in situ hybridization and PCR analysis.	Poly I-C	0-8	transforming growth factor, beta 1	Rattus norvegicus	154-164
8841427-9	1996	These studies suggests that poly I:C upregulates the biosynthesis of adhesion molecules, extracellular matrix proteins (ECM), and TGF-beta 1 in the wound bed.	Poly I-C	28-36	transforming growth factor, beta 1	Rattus norvegicus	130-140
9104805-7	1997	The IL-6 requirement appeared to be specific for virus-type stimuli as the synthetic analogue of viral nucleic acid, polyinosinic-polycytidylic acid, also induced IL-6-dependent glucocorticoid release, but treatments with the bacterial product lipopolysaccharide and a non-immune physical restraint stressor elicited IL-6-independent responses.	Poly I-C	117-148	interleukin 6	Homo sapiens	4-8
9104805-7	1997	The IL-6 requirement appeared to be specific for virus-type stimuli as the synthetic analogue of viral nucleic acid, polyinosinic-polycytidylic acid, also induced IL-6-dependent glucocorticoid release, but treatments with the bacterial product lipopolysaccharide and a non-immune physical restraint stressor elicited IL-6-independent responses.	Poly I-C	117-148	interleukin 6	Homo sapiens	163-167
9104805-7	1997	The IL-6 requirement appeared to be specific for virus-type stimuli as the synthetic analogue of viral nucleic acid, polyinosinic-polycytidylic acid, also induced IL-6-dependent glucocorticoid release, but treatments with the bacterial product lipopolysaccharide and a non-immune physical restraint stressor elicited IL-6-independent responses.	Poly I-C	117-148	interleukin 6	Homo sapiens	163-167
9064483-3	1997	The rate of transcription of CYP1A1 and CYP1A2 genes was significantly decreased in hepatic nuclei isolated from male rats treated with polyinosinic acid-polycytidylic acid (10 mg/kg).	Poly I-C	136-172	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	29-35
9064483-3	1997	The rate of transcription of CYP1A1 and CYP1A2 genes was significantly decreased in hepatic nuclei isolated from male rats treated with polyinosinic acid-polycytidylic acid (10 mg/kg).	Poly I-C	136-172	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	40-46
8806499-4	1996	We found that addition of a synthetic peptide corresponding to residues 54-74 of murine PKR or residues 60-80 of human PKR inhibited the autophosphorylation and activation of the kinase by either poly(I)-poly(C) or the 82-nucleotide-long TAR RNA.	Poly I-C	196-211	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	88-91
8806499-4	1996	We found that addition of a synthetic peptide corresponding to residues 54-74 of murine PKR or residues 60-80 of human PKR inhibited the autophosphorylation and activation of the kinase by either poly(I)-poly(C) or the 82-nucleotide-long TAR RNA.	Poly I-C	196-211	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	119-122
8824710-4	1995	Since we have further demonstrated that poly I:C administration to BB rats increases NK cell number and levels of inducers of NK cell activity, interferon-alpha and IL-6 which is described therein, we tested the hypothesis that NK cell activity plays an important role in poly I:C accelerated disease.	Poly I-C	40-48	interleukin 6	Rattus norvegicus	165-169
8658169-3	1996	In mice, T cell proliferation in viral infections preferentially affected the CD44hi subset of CD8+ cells and was mimicked by injection of polyinosinic-polycytidylic acid [poly(I:C)], an inducer of type I interferon (IFN I), and also by purified IFN I; such proliferation was not associated with up-regulation of CD69 or CD25 expression, which implies that TCR signaling was not involved.	Poly I-C	139-170	CD44 antigen	Mus musculus	78-82
8658169-3	1996	In mice, T cell proliferation in viral infections preferentially affected the CD44hi subset of CD8+ cells and was mimicked by injection of polyinosinic-polycytidylic acid [poly(I:C)], an inducer of type I interferon (IFN I), and also by purified IFN I; such proliferation was not associated with up-regulation of CD69 or CD25 expression, which implies that TCR signaling was not involved.	Poly I-C	139-170	CD69 antigen	Mus musculus	313-317
8658169-3	1996	In mice, T cell proliferation in viral infections preferentially affected the CD44hi subset of CD8+ cells and was mimicked by injection of polyinosinic-polycytidylic acid [poly(I:C)], an inducer of type I interferon (IFN I), and also by purified IFN I; such proliferation was not associated with up-regulation of CD69 or CD25 expression, which implies that TCR signaling was not involved.	Poly I-C	139-170	interleukin 2 receptor, alpha chain	Mus musculus	321-325
8658169-3	1996	In mice, T cell proliferation in viral infections preferentially affected the CD44hi subset of CD8+ cells and was mimicked by injection of polyinosinic-polycytidylic acid [poly(I:C)], an inducer of type I interferon (IFN I), and also by purified IFN I; such proliferation was not associated with up-regulation of CD69 or CD25 expression, which implies that TCR signaling was not involved.	Poly I-C	139-170	T cell receptor alpha variable 6-3	Mus musculus	357-360
7594623-4	1995	We report a method for positively selecting NK1.1+ spleen cells from normal and Poly I:C-stimulated C56Bl/6 mice using a magnetic cell separation technique known as MACS.	Poly I-C	80-88	tachykinin 1	Mus musculus	44-47
7594623-5	1995	Our results show that cytotoxic activity directed at YAC-1 target cells by normal and Poly I:C-stimulated spleen cells could be increased five-fold using this method.	Poly I-C	86-94	ADP-ribosyltransferase 1	Mus musculus	53-58
7565643-6	1995	However, Poly I:C decreased only Zn1-stimulated release of IL-1 alpha.	Poly I-C	9-17	interleukin 1 alpha	Homo sapiens	59-69
8562499-2	1995	We demonstrate that LCMV infection is more effective than polyinosinic:polycytidylic acid (poly I:C) at stimulating NK activity in beta 2m- mice.	Poly I-C	91-99	beta-2 microglobulin	Mus musculus	131-138
7636259-7	1995	Our studies indicate that MV, TNF-alpha, or PIPC induces NF-kappa B (p50 and p65 subunits) binding to positive regulatory domain II in the glioma cell line.	Poly I-C	44-48	nuclear factor kappa B subunit 1	Homo sapiens	57-67
7636259-7	1995	Our studies indicate that MV, TNF-alpha, or PIPC induces NF-kappa B (p50 and p65 subunits) binding to positive regulatory domain II in the glioma cell line.	Poly I-C	44-48	nuclear factor kappa B subunit 1	Homo sapiens	69-72
7636259-7	1995	Our studies indicate that MV, TNF-alpha, or PIPC induces NF-kappa B (p50 and p65 subunits) binding to positive regulatory domain II in the glioma cell line.	Poly I-C	44-48	RELA proto-oncogene, NF-kB subunit	Homo sapiens	77-80
7589141-4	1995	Poly I:C also showed the ability to stimulate the production of noticeable amounts of both IFN-alpha and IL-12 by human monocytes.	Poly I-C	0-8	interferon alpha 1	Homo sapiens	91-100
7810770-7	1994	Both intravenously injected LPS and poly I:C increased Tco, decreased leukocytes, and increased ceruloplasmin.	Poly I-C	36-44	ceruloplasmin	Oryctolagus cuniculus	96-109
9363235-2	1995	Polyriboinosinic/polyribocytidylic acid [poly(I:C)] induced exclusively IFN-beta in trophoblast cultures, whereas viruses induced mixtures of IFN-alpha subtypes and -beta.	Poly I-C	0-39	interferon beta 1	Homo sapiens	72-80
9363235-2	1995	Polyriboinosinic/polyribocytidylic acid [poly(I:C)] induced exclusively IFN-beta in trophoblast cultures, whereas viruses induced mixtures of IFN-alpha subtypes and -beta.	Poly I-C	41-50	interferon beta 1	Homo sapiens	72-80
7825185-0	1995	Effect of TNF alpha production inhibitors BRL 61063 and pentoxifylline on the response of rats to poly I:C.	Poly I-C	98-106	tumor necrosis factor	Rattus norvegicus	10-19
7882905-2	1994	Because the release of PAF is stimulated by tumor necrosis factor (TNF), this study was designed to measure the effects of polyI:C on TNF-induced lung inflammation and injury.	Poly I-C	123-130	tumor necrosis factor	Oryctolagus cuniculus	134-137
7524103-7	1994	Poly I:C also caused a significant but less pronounced increase in the life span of MCMV-infected SCID mice in which the NK cells or macrophages had been depleted by treatment with anti-asialo GM1 or anti-Mac1 antibody, respectively.	Poly I-C	0-8	integrin alpha M	Mus musculus	205-209
7882905-13	1994	PolyI:C, which attenuates TNF-induced injury, also modulates effects of TNF on mononuclear cell and granulocyte infiltration in the lung.	Poly I-C	0-7	tumor necrosis factor	Oryctolagus cuniculus	26-29
7882905-13	1994	PolyI:C, which attenuates TNF-induced injury, also modulates effects of TNF on mononuclear cell and granulocyte infiltration in the lung.	Poly I-C	0-7	tumor necrosis factor	Oryctolagus cuniculus	72-75
7913113-9	1994	Finally, endogenous IFN-alpha/beta production induced by poly I.C also inhibited Ag-induced eosinophil infiltration in the trachea and this inhibition of the eosinophil infiltration was abrogated by pretreatment with anti-IFN-alpha/beta mAb.	Poly I-C	57-65	interferon alpha	Mus musculus	20-29
7913113-9	1994	Finally, endogenous IFN-alpha/beta production induced by poly I.C also inhibited Ag-induced eosinophil infiltration in the trachea and this inhibition of the eosinophil infiltration was abrogated by pretreatment with anti-IFN-alpha/beta mAb.	Poly I-C	57-65	interferon alpha	Mus musculus	222-231
8260452-3	1993	This interstrain variation is apparently the result of LPS-specific signal differences since macrophages derived from both Lpsn and Lpsd mouse strains are able to produce comparable levels of IFN-gamma-specific mRNA following stimulation with polyinosinic-polycytidylic acid.	Poly I-C	243-274	interferon gamma	Mus musculus	192-201
8027591-7	1994	Poly(I:C)-mediated reversal of IFN-gamma-resistant phenotype and induction of IDO and IRF1 messages are inhibited by 2-aminopurine.	Poly I-C	0-9	interferon gamma	Homo sapiens	31-40
8027591-7	1994	Poly(I:C)-mediated reversal of IFN-gamma-resistant phenotype and induction of IDO and IRF1 messages are inhibited by 2-aminopurine.	Poly I-C	0-9	indoleamine 2,3-dioxygenase 1	Homo sapiens	78-81
8027591-7	1994	Poly(I:C)-mediated reversal of IFN-gamma-resistant phenotype and induction of IDO and IRF1 messages are inhibited by 2-aminopurine.	Poly I-C	0-9	interferon regulatory factor 1	Homo sapiens	86-90
8283061-7	1994	Pretreatment of KS cells with poly (I:C) for 24 h followed by removal of the poly (I:C) led to high levels of IL-6 secreted into medium that induced proliferation in KS cells.	Poly I-C	30-39	interleukin 6	Homo sapiens	110-114
8304411-3	1994	Exposure of IFN-primed macrophages to polyinosinic-polycytidylic acid in the presence of the PKC inhibitors H-7 or sphingosine or after downregulation of PKC with phorbol myristate acetate markedly inhibited Bf synthesis.	Poly I-C	38-69	interferon alpha 1	Homo sapiens	12-15
8301591-3	1994	We investigated the effects of polyinosinic acid-polycytidylic acid, a potent stimulator of interferon alpha/beta production on CYP1A and CYP2E induction in the rat.	Poly I-C	31-67	interferon beta 1	Rattus norvegicus	92-113
8301591-3	1994	We investigated the effects of polyinosinic acid-polycytidylic acid, a potent stimulator of interferon alpha/beta production on CYP1A and CYP2E induction in the rat.	Poly I-C	31-67	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	138-143
8301591-4	1994	Polyinosinic acid-polycytidylic acid down regulated the constitutive and pyridine-induced expression of CYP2E1 and the pyridine- and beta-naphthoflavone-induced expression of CYP1A1 as demonstrated by metabolic activity and immunoblot analyses.	Poly I-C	0-36	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	104-110
8301591-4	1994	Polyinosinic acid-polycytidylic acid down regulated the constitutive and pyridine-induced expression of CYP2E1 and the pyridine- and beta-naphthoflavone-induced expression of CYP1A1 as demonstrated by metabolic activity and immunoblot analyses.	Poly I-C	0-36	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	175-181
8301591-5	1994	Depression of CYP2E1 and CYP1A1 protein expression by polyinosinic acid-polycytidylic acid was accompanied by a corresponding decrease in mRNA encoding these proteins.	Poly I-C	54-90	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	14-20
8301591-5	1994	Depression of CYP2E1 and CYP1A1 protein expression by polyinosinic acid-polycytidylic acid was accompanied by a corresponding decrease in mRNA encoding these proteins.	Poly I-C	54-90	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	25-31
8026885-12	1994	We have confirmed our in vivo results by in vitro cytotoxicity assays using poly I:C induced NK and IL-2 activated LAK cells.	Poly I-C	76-84	interleukin 2	Mus musculus	100-104
7518192-4	1994	We now report that parenteral poly I:C induces rat pancreatic endothelium to hyperexpress intercellular adhesion molecule 1 (CD54).	Poly I-C	30-38	intercellular adhesion molecule 1	Rattus norvegicus	90-123
7518192-4	1994	We now report that parenteral poly I:C induces rat pancreatic endothelium to hyperexpress intercellular adhesion molecule 1 (CD54).	Poly I-C	30-38	intercellular adhesion molecule 1	Rattus norvegicus	125-129
7505668-7	1993	Treatment with 1,000 U/ml of IFN-alpha/beta induced protection only of FLC-745 cells, injected in Poly I:C stimulated hosts.	Poly I-C	98-106	interferon alpha	Mus musculus	29-38
1330423-5	1992	For the production of IFN, AM cultures were treated with polyinosinic:polycytidylic acid (Poly I:C) diluted in tissue culture media at a concentration of 5 micrograms/10(6) cells.	Poly I-C	57-88	interferon alpha 1	Homo sapiens	22-25
8396072-5	1993	In contrast, anti-TNF-alpha, anti-IFN-alpha/beta anti-IFN-beta antibodies and inhibitors of nitric oxide and C1q production were all able to partially abrogate Poly I:C-induced cytostatic activity, suggesting that multiple mechanisms are involved in macrophage cytostasis.	Poly I-C	160-168	tumor necrosis factor	Homo sapiens	18-27
8396072-5	1993	In contrast, anti-TNF-alpha, anti-IFN-alpha/beta anti-IFN-beta antibodies and inhibitors of nitric oxide and C1q production were all able to partially abrogate Poly I:C-induced cytostatic activity, suggesting that multiple mechanisms are involved in macrophage cytostasis.	Poly I-C	160-168	interferon alpha 1	Homo sapiens	34-43
8396072-5	1993	In contrast, anti-TNF-alpha, anti-IFN-alpha/beta anti-IFN-beta antibodies and inhibitors of nitric oxide and C1q production were all able to partially abrogate Poly I:C-induced cytostatic activity, suggesting that multiple mechanisms are involved in macrophage cytostasis.	Poly I-C	160-168	complement C1q A chain	Homo sapiens	109-112
8255150-0	1993	The effects of an interferon inducer, polyriboinosinic polyribocytidylic acid on cytochrome P-450 dependent hepatic progesterone metabolism.	Poly I-C	38-77	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	81-97
8255150-1	1993	A time course study on the effects of an interferon inducing agent, polyriboinosinic polyribocytidylic acid (poly rIrC) on the hepatic cytochrome P-450 dependent progesterone metabolism was performed.	Poly I-C	68-107	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	135-151
8255150-1	1993	A time course study on the effects of an interferon inducing agent, polyriboinosinic polyribocytidylic acid (poly rIrC) on the hepatic cytochrome P-450 dependent progesterone metabolism was performed.	Poly I-C	109-118	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	135-151
1447187-0	1992	Interleukin-1 alpha mediates an alternative pathway for the antiproliferative action of poly(I.C) on human endothelial cells.	Poly I-C	88-97	interleukin 1 alpha	Homo sapiens	0-19
1447187-4	1992	In addition, the mRNA levels for the cytokines interleukin-1 alpha (IL-1 alpha) and interferon-beta 1 are induced in poly(I.C)-treated cells.	Poly I-C	117-126	interleukin 1 alpha	Homo sapiens	47-66
1447187-4	1992	In addition, the mRNA levels for the cytokines interleukin-1 alpha (IL-1 alpha) and interferon-beta 1 are induced in poly(I.C)-treated cells.	Poly I-C	117-126	interleukin 1 alpha	Homo sapiens	68-78
1447187-4	1992	In addition, the mRNA levels for the cytokines interleukin-1 alpha (IL-1 alpha) and interferon-beta 1 are induced in poly(I.C)-treated cells.	Poly I-C	117-126	interferon beta 1	Homo sapiens	84-101
1447187-5	1992	Moreover, the growth inhibitory effects of poly(I.C) are relieved when cells are grown in the presence of an IL-1 alpha antisense oligonucleotide to the human IL-1 alpha transcript.	Poly I-C	43-52	interleukin 1 alpha	Homo sapiens	109-119
1447187-5	1992	Moreover, the growth inhibitory effects of poly(I.C) are relieved when cells are grown in the presence of an IL-1 alpha antisense oligonucleotide to the human IL-1 alpha transcript.	Poly I-C	43-52	interleukin 1 alpha	Homo sapiens	159-169
1447187-6	1992	Thus, the effects of poly(I.C) appear to be mediated, in part, through the function of IL-1 alpha, suggesting an alternative pathway for dsRNA-mediated inhibition of human endothelial cell growth.	Poly I-C	21-30	interleukin 1 alpha	Homo sapiens	87-97
1451333-1	1992	We have previously demonstrated that IFN-alpha/beta, poly(I:C) (an inducer of IFN-alpha/beta), or IFN-gamma can inhibit the ability of KLH-pulsed peritoneal macrophages (M phi) to induce the proliferation of syngeneic, KLH-immune T lymphocytes from CBA/J mice.	Poly I-C	53-61	interferon alpha	Mus musculus	78-87
1451333-3	1992	The production of IL-2 by T cells cultured with poly(I:C)-treated, KLH-pulsed M phi was decreased by 80%; however, addition of exogenous rIL-2 could not restore proliferation.	Poly I-C	48-57	interleukin 2	Mus musculus	18-22
1451333-3	1992	The production of IL-2 by T cells cultured with poly(I:C)-treated, KLH-pulsed M phi was decreased by 80%; however, addition of exogenous rIL-2 could not restore proliferation.	Poly I-C	48-57	interleukin 2	Rattus norvegicus	137-142
1451333-4	1992	Although IL-1 production by poly(I:C)-treated M phi was comparable to the level produced by saline-treated, KLH-pulsed M phi controls, addition of exogenous rIL-1 was still examined to explore the possibility that a greater amount of IL-1 may be needed to induce T cell proliferation with poly(I:C)-treated, KLH-pulsed M phi.	Poly I-C	28-37	interleukin 1 complex	Mus musculus	9-13
1451333-6	1992	Interestingly, the addition of combinations of IL-1 and IL-6 increased the proliferation of T cells in response to KLH presented by either saline- or poly(I:C)-treated M phi.	Poly I-C	150-159	interleukin 1 complex	Mus musculus	47-51
1451333-6	1992	Interestingly, the addition of combinations of IL-1 and IL-6 increased the proliferation of T cells in response to KLH presented by either saline- or poly(I:C)-treated M phi.	Poly I-C	150-159	interleukin 6	Mus musculus	56-60
8370404-8	1993	Lymph node cells from infected and poly I:C-treated BALB/c mice released higher amount of IFN-gamma in vitro than cells from control mice.	Poly I-C	35-43	interferon gamma	Mus musculus	90-99
8342604-7	1993	Conversely, incubation with poly[I:C] prior to exposure to beta-1,3-glucan substantially blocked the stimulation of beta-glucuronidase and platelet-derived growth factor B expression, indicating that these two responses were expressed in a mutually antagonistic fashion.	Poly I-C	28-36	hemoglobin, beta adult major chain	Mus musculus	59-67
7901291-4	1993	Poly(I:C) mediated reversal of the IFN-gamma-resistant phenotype and induction of IDO mRNA are inhibited by 2-aminopurine.	Poly I-C	0-8	interferon gamma	Homo sapiens	35-44
7901291-4	1993	Poly(I:C) mediated reversal of the IFN-gamma-resistant phenotype and induction of IDO mRNA are inhibited by 2-aminopurine.	Poly I-C	0-8	indoleamine 2,3-dioxygenase 1	Homo sapiens	82-85
8225390-9	1993	The cells were induced either with inactivated Newcastle Disease Virus (NDV), Sendai Virus, or the synthetic stimulus poly I:C IFN-alpha expression was not detected on the transcriptional or the protein level.	Poly I-C	118-126	interferon alpha 1	Homo sapiens	127-130
7686458-0	1993	Modulation of rat hepatic CYP3A1 induction by the interferon inducer polyinosinic acid-polycytidylic acid (polyic).	Poly I-C	69-105	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	26-32
7686458-3	1993	We examined the effect of interferon [produced in response to polyinosinic acid-polycytidylic acid (polyIC; 10 mg/kg) administration] on the induction of CYP3A1 in the female rat by the macrolide antibiotic troleandomycin (TAO; 200 mg/kg), and the antiglucocorticoid pregnenolone-16 alpha-carbonitrile (PCN; 300 mg/kg).	Poly I-C	62-98	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	154-160
8418469-9	1993	However, poly(I)-poly(C) (a potent inducer of IL-6) also showed AEF activity, suggesting that not a single cytokine but rather a certain combination of different cytokines could be decisive in AA amyloidogenesis.	Poly I-C	9-24	interleukin 6	Homo sapiens	46-50
1639344-5	1992	Furthermore, ursodeoxycholic acid suppressed interleukin-2 and interleukin-4 production induced by concanavalin A and interferon-gamma production induced by polyinosinic-polycytidylic acid, but it did not affect interleukin-1 and interleukin-6 production induced by lipopolysaccharide in peripheral blood mononuclear cells.	Poly I-C	157-188	interferon gamma	Homo sapiens	118-134
1384719-1	1992	The double-stranded RNA polyinosinic acid-polycytidylic acid (PolyIC) is an inducer of interferons alpha and beta (IFN) genes.	Poly I-C	24-60	interferon beta 1	Homo sapiens	87-113
1384719-1	1992	The double-stranded RNA polyinosinic acid-polycytidylic acid (PolyIC) is an inducer of interferons alpha and beta (IFN) genes.	Poly I-C	24-60	interferon alpha 1	Homo sapiens	115-118
1375119-12	1992	In contrast, polymerization of serum C9 was inhibited by exogenous HRG during poly I:C activation of serum or incubation under low ionic strength conditions.	Poly I-C	78-86	histidine-rich glycoprotein	Oryctolagus cuniculus	67-70
1839310-2	1991	The poly(I:C)-induced intratumor hemorrhagic reaction was associated with production of appreciable quantities of tumor necrosis factor (TNF) by the host.	Poly I-C	4-13	tumor necrosis factor	Mus musculus	114-135
1591717-0	1992	Polyinosinic-polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose in combination with interleukin 2 in patients with cancer: clinical and immunological effects.	Poly I-C	0-31	interleukin 2	Homo sapiens	108-121
1640118-4	1992	Liver AT was also induced by poly(I:C), which is a potent IFN inducer.	Poly I-C	29-37	interferon alpha 1	Homo sapiens	58-61
1839310-2	1991	The poly(I:C)-induced intratumor hemorrhagic reaction was associated with production of appreciable quantities of tumor necrosis factor (TNF) by the host.	Poly I-C	4-13	tumor necrosis factor	Mus musculus	137-140
1902145-1	1991	We have previously demonstrated that IFN-alpha/beta, poly I:C (an inducer of IFN-alpha/beta), and IFN-gamma can inhibit the ability of KLH-pulsed peritoneal macrophages to induce proliferation of syngeneic, KLH immune T lymphocytes in CBA/J mice.	Poly I-C	53-61	interferon alpha	Mus musculus	77-86
1660913-0	1991	Poly I:C-induced anti-herpes simplex virus type 1 activity in inflammatory macrophages is mediated by induction of interferon-beta.	Poly I-C	0-8	interferon beta 1	Homo sapiens	115-130
1660913-4	1991	In addition, we demonstrate that supernatants from macrophages treated with Poly I:C contain IFN-beta but not IFN-alpha.	Poly I-C	76-84	interferon beta 1	Homo sapiens	93-101
1660913-5	1991	Taken together these data indicate that the antiviral effects of Poly I:C in inflammatory macrophages are mediated solely by IFN-beta, which acts in an autocrine manner to induce resistance to HSV-1.	Poly I-C	65-73	interferon beta 1	Homo sapiens	125-133
2208307-6	1990	GM-CSF treatment enabled M phi to produce more interleukin (IL)-1 and IL-6 upon stimulation with lipopolysaccharides or polyinosinic-polycytidylic acid, but was unable to stimulate M phi directly.	Poly I-C	120-151	colony stimulating factor 2	Homo sapiens	0-6
2262910-6	1990	Conversely, a maximal 7-fold enhancement of ALT concentration was observed in CD-1 mice when 300 mg/kg of acetaminophen was given 32 days after Poly I-C (P less than 0.05).	Poly I-C	144-152	glutamic pyruvic transaminase, soluble	Mus musculus	44-47
2262910-12	1990	Poly I-C pretreatment produced a 5-fold increase in acetaminophen-induced ALT release (P less than 0.05), which correlated with histologic evidence of centrilobular necrosis.	Poly I-C	0-8	glutamic pyruvic transaminase, soluble	Mus musculus	74-77
2262910-13	1990	Poly I-C pretreatment produced respective 3-fold and 1.3-fold increases in the production of cysteine and mercapturic acid conjugates (P less than 0.05), which correlated with peak ALT concentrations (cysteine, r = 0.92, P less than 0.001; mercapturic acid, r = 0.75, P = 0.006).	Poly I-C	0-8	glutamic pyruvic transaminase, soluble	Mus musculus	181-184
2226642-7	1990	Since the inhibition of mitogenic stimulation by poly(I:C) is completely overcome by antisera recognizing interferon-beta (IFN-beta) and interleukin-6 (IL-6), we tested the effect of IL-6 and IFN-beta on EGF mitogenicity.	Poly I-C	49-58	interferon beta 1	Homo sapiens	106-121
2226642-7	1990	Since the inhibition of mitogenic stimulation by poly(I:C) is completely overcome by antisera recognizing interferon-beta (IFN-beta) and interleukin-6 (IL-6), we tested the effect of IL-6 and IFN-beta on EGF mitogenicity.	Poly I-C	49-58	interferon beta 1	Homo sapiens	123-131
2226642-7	1990	Since the inhibition of mitogenic stimulation by poly(I:C) is completely overcome by antisera recognizing interferon-beta (IFN-beta) and interleukin-6 (IL-6), we tested the effect of IL-6 and IFN-beta on EGF mitogenicity.	Poly I-C	49-58	interleukin 6	Homo sapiens	137-150
2208307-6	1990	GM-CSF treatment enabled M phi to produce more interleukin (IL)-1 and IL-6 upon stimulation with lipopolysaccharides or polyinosinic-polycytidylic acid, but was unable to stimulate M phi directly.	Poly I-C	120-151	interleukin 1 alpha	Homo sapiens	47-65
2208307-6	1990	GM-CSF treatment enabled M phi to produce more interleukin (IL)-1 and IL-6 upon stimulation with lipopolysaccharides or polyinosinic-polycytidylic acid, but was unable to stimulate M phi directly.	Poly I-C	120-151	interleukin 6	Homo sapiens	70-74
2111350-0	1990	Poly I:C activated macrophages are tumoricidal for TNF-alpha-resistant 3LL tumor cells.	Poly I-C	0-8	tumor necrosis factor	Mus musculus	51-60
1695235-0	1990	Macrophages from C3H/HeJ mice require an additional step to produce monokines: synergistic effects of silica and poly(I:C) in the release of interleukin 1.	Poly I-C	113-121	interleukin 1 complex	Mus musculus	141-154
1695235-6	1990	In contrast, poly(I:C) was able to induce the release of FRM by C3H/HeJ macrophages but not that of IL-1; moreover, the addition of silica to poly(I:C)-stimulated cells led to an IL-1 release similar to that obtained with normal mice treated with silica alone.	Poly I-C	13-21	interleukin 1 complex	Mus musculus	179-183
1695235-6	1990	In contrast, poly(I:C) was able to induce the release of FRM by C3H/HeJ macrophages but not that of IL-1; moreover, the addition of silica to poly(I:C)-stimulated cells led to an IL-1 release similar to that obtained with normal mice treated with silica alone.	Poly I-C	13-22	interleukin 1 complex	Mus musculus	179-183
2111350-5	1990	Hence, Poly I:C-induced macrophage-mediated cytolysis of 3LL-R cells may result from 1) the induction of macrophages by Poly I:C to secrete high amounts of TNF-alpha and class I IFN and 2) a synergism between IFN-alpha/IFN-beta and TNF-alpha on lysis of 3LL-R cells.	Poly I-C	7-15	tumor necrosis factor	Mus musculus	156-165
2317956-7	1990	Several mechanisms may contribute to the overall effect of this treatment; a reduction in the mitotic indices of lung colonies (observed in poly I:C treated mice) and also NK cells appeared to be important for the effectiveness of poly I:C since the reduction in experimental metastasis was abrogated by concomitant treatment with anti-asialo GM1 serum.	Poly I-C	231-239	coenzyme Q10A	Mus musculus	343-346
2111350-5	1990	Hence, Poly I:C-induced macrophage-mediated cytolysis of 3LL-R cells may result from 1) the induction of macrophages by Poly I:C to secrete high amounts of TNF-alpha and class I IFN and 2) a synergism between IFN-alpha/IFN-beta and TNF-alpha on lysis of 3LL-R cells.	Poly I-C	7-15	carcinogen-induced lung adenoma susceptibility 2	Mus musculus	170-187
2111350-5	1990	Hence, Poly I:C-induced macrophage-mediated cytolysis of 3LL-R cells may result from 1) the induction of macrophages by Poly I:C to secrete high amounts of TNF-alpha and class I IFN and 2) a synergism between IFN-alpha/IFN-beta and TNF-alpha on lysis of 3LL-R cells.	Poly I-C	7-15	interferon alpha	Mus musculus	209-218
2111350-5	1990	Hence, Poly I:C-induced macrophage-mediated cytolysis of 3LL-R cells may result from 1) the induction of macrophages by Poly I:C to secrete high amounts of TNF-alpha and class I IFN and 2) a synergism between IFN-alpha/IFN-beta and TNF-alpha on lysis of 3LL-R cells.	Poly I-C	7-15	interferon beta 1, fibroblast	Mus musculus	219-227
2111350-5	1990	Hence, Poly I:C-induced macrophage-mediated cytolysis of 3LL-R cells may result from 1) the induction of macrophages by Poly I:C to secrete high amounts of TNF-alpha and class I IFN and 2) a synergism between IFN-alpha/IFN-beta and TNF-alpha on lysis of 3LL-R cells.	Poly I-C	7-15	tumor necrosis factor	Mus musculus	232-241
2111350-5	1990	Hence, Poly I:C-induced macrophage-mediated cytolysis of 3LL-R cells may result from 1) the induction of macrophages by Poly I:C to secrete high amounts of TNF-alpha and class I IFN and 2) a synergism between IFN-alpha/IFN-beta and TNF-alpha on lysis of 3LL-R cells.	Poly I-C	120-128	tumor necrosis factor	Mus musculus	156-165
2111350-5	1990	Hence, Poly I:C-induced macrophage-mediated cytolysis of 3LL-R cells may result from 1) the induction of macrophages by Poly I:C to secrete high amounts of TNF-alpha and class I IFN and 2) a synergism between IFN-alpha/IFN-beta and TNF-alpha on lysis of 3LL-R cells.	Poly I-C	120-128	carcinogen-induced lung adenoma susceptibility 2	Mus musculus	170-187
1689761-5	1990	These poly(I:C)-induced blast NK cells were responsive to IL-2, but, when compared with in vivo activated T cells, responsiveness required 1,000-fold higher concentrations of the factor.	Poly I-C	6-15	interleukin 2	Mus musculus	58-62
2107253-13	1990	Depletion of sPEL and spleen T cells by adherence to IFN-gamma stimulated EC decreased the in vivo migration of the lymphocytes to skin sites injected with IFN-gamma, IFN-alpha/beta, TNF-alpha, poly I:C, LPS, and to delayed-type hypersensitivity reactions by 50%, and significantly increased the migration of these cells to normal lymph nodes, as compared to unfractionated lymphocytes.	Poly I-C	194-202	interferon gamma	Rattus norvegicus	53-62
2107257-5	1990	DHP-treated macrophages were inhibited in their response to direct activation and triggering of IFN-gamma-primed macrophages by lipid A, Poly I:C, and cobra venom factor for tumor cytotoxicity.	Poly I-C	137-145	interferon gamma	Mus musculus	96-105
1689761-6	1990	The technique of in situ hybridization was used to evaluate induction of IL-2 gene expression after poly(I:C) treatment in vivo.	Poly I-C	100-109	interleukin 2	Mus musculus	73-77
1689761-10	1990	To assess the IL-2 dependence of in vivo NK cell expansion, poly(I:C)-treated athymic mice were given cyclosporin A (CsA), an agent that regulates IL-2 production at the level of gene transcription.	Poly I-C	60-69	interleukin 2	Mus musculus	14-18
33766701-5	2021	We show that prenatal immune activation of toll-like receptor 3, by the viral mimetic polyinosinic-polycytidylic acid (poly(I:C)), led to disrupted maternal care in that dams built poorer quality nests, an effect corrected by EE housing.	Poly I-C	86-117	toll-like receptor 3	Mus musculus	43-63
2153928-1	1990	Treatment of Daudi or HeLa cells with human interferon (IFN) alpha 8 before induction with either poly(I)-poly(C) or Sendai virus resulted in an 8- to 100-fold increase in IFN production.	Poly I-C	98-113	interferon alpha 8	Homo sapiens	44-68
2153928-1	1990	Treatment of Daudi or HeLa cells with human interferon (IFN) alpha 8 before induction with either poly(I)-poly(C) or Sendai virus resulted in an 8- to 100-fold increase in IFN production.	Poly I-C	98-113	interferon alpha 1	Homo sapiens	56-59
2153928-5	1990	IFN treatment of either Daudi or HeLa cells transfected with the human IFN-beta promoter (-282 to -37) linked to the chloramphenicol acetyltransferase (CAT) gene resulted in an increase in CAT activity after induction with poly(I)-poly(C) or Sendai virus.	Poly I-C	223-237	interferon alpha 1	Homo sapiens	0-3
2153928-5	1990	IFN treatment of either Daudi or HeLa cells transfected with the human IFN-beta promoter (-282 to -37) linked to the chloramphenicol acetyltransferase (CAT) gene resulted in an increase in CAT activity after induction with poly(I)-poly(C) or Sendai virus.	Poly I-C	223-237	interferon beta 1	Homo sapiens	71-79
33809574-5	2021	Further, we evaluated the combinatorial effect of curcumin and toll-like receptor 3 (TLR3) agonist Poly I:C (PIC) on NF-kappaB inhibition and regulatory T-cell (Treg) attraction.	Poly I-C	99-107	nuclear factor kappa B subunit 1	Homo sapiens	117-126
33766701-5	2021	We show that prenatal immune activation of toll-like receptor 3, by the viral mimetic polyinosinic-polycytidylic acid (poly(I:C)), led to disrupted maternal care in that dams built poorer quality nests, an effect corrected by EE housing.	Poly I-C	119-128	toll-like receptor 3	Mus musculus	43-63
33232788-4	2021	MER and AXL upregulation was more efficiently induced by a vaccine containing Imiquimod than by a poly(I:C)-containing vaccine.	Poly I-C	98-107	MER proto-oncogene tyrosine kinase	Mus musculus	0-3
33232788-4	2021	MER and AXL upregulation was more efficiently induced by a vaccine containing Imiquimod than by a poly(I:C)-containing vaccine.	Poly I-C	98-107	AXL receptor tyrosine kinase	Mus musculus	8-11
26364740-9	2015	Furthermore, the promoter activities of CsIL-17C, CsIL-17D, and CsIL-17F, but not CsIL-17Fl, were modulated to significant extents by lipopolysaccharide, PolyI:C, and PMA.	Poly I-C	154-161	interleukin-17C	Cynoglossus semilaevis	40-48
26364740-9	2015	Furthermore, the promoter activities of CsIL-17C, CsIL-17D, and CsIL-17F, but not CsIL-17Fl, were modulated to significant extents by lipopolysaccharide, PolyI:C, and PMA.	Poly I-C	154-161	interleukin-17D	Cynoglossus semilaevis	50-58
34673140-6	2022	After stimulation with polyinosinic-polycytidylic acid (poly(I:C)), the expression levels of OnTLR1 were significantly downregulated in the intestine, whereas OnTLR1 transcripts were significantly upregulated in the kidney.	Poly I-C	23-54	toll-like receptor 1	Oreochromis niloticus	93-99
23861935-9	2013	Stimulation, most prominently with poly(I:C), down-regulated myosin light chain kinase and cysteinyl leukotriene 1 receptor expression and up-regulated beta2-adrenoceptor expression.	Poly I-C	35-43	adrenoceptor beta 2	Homo sapiens	152-170
34673140-6	2022	After stimulation with polyinosinic-polycytidylic acid (poly(I:C)), the expression levels of OnTLR1 were significantly downregulated in the intestine, whereas OnTLR1 transcripts were significantly upregulated in the kidney.	Poly I-C	23-54	toll-like receptor 1	Oreochromis niloticus	159-165
34626690-5	2022	Exogenous overexpression of porTRIM35 significantly up-regulated the mRNA expression level of IFN-beta in swine testicular (ST) cell in response to poly(I:C) stimulation, whereas knockdown endogenous expression of porTRIM35 lead to a decrease in the expression level of IFN-beta.	Poly I-C	148-157	interferon beta 1	Sus scrofa	94-102
34801710-7	2022	When injected with poly(I:C), an approximately 17-fold upregulation (compared to the control) of viperin was detected in the blood after 24 h. Furthermore, non-viral immune stimuli, including Lactococcus garvieae (L. garvieae) and lipopolysaccharide (LPS), that were injected into redlip mullets were not found to induce considerable levels of viperin expression.	Poly I-C	19-28	radical S-adenosyl methionine domain containing 2	Homo sapiens	97-104
34673140-6	2022	After stimulation with polyinosinic-polycytidylic acid (poly(I:C)), the expression levels of OnTLR1 were significantly downregulated in the intestine, whereas OnTLR1 transcripts were significantly upregulated in the kidney.	Poly I-C	56-65	toll-like receptor 1	Oreochromis niloticus	93-99
34673140-6	2022	After stimulation with polyinosinic-polycytidylic acid (poly(I:C)), the expression levels of OnTLR1 were significantly downregulated in the intestine, whereas OnTLR1 transcripts were significantly upregulated in the kidney.	Poly I-C	56-65	toll-like receptor 1	Oreochromis niloticus	159-165
34673140-11	2022	Binding assays revealed the specificity of OnTLR1 for pathogen-associated molecular patterns (PAMPs) and bacteria that included S. agalactiae, Aeromonas hydrophila and poly(I:C) and LPS.	Poly I-C	168-177	toll-like receptor 1	Oreochromis niloticus	43-49
34454033-5	2022	Maoto significantly decreased PolyI:C-induced TNF-alpha levels and increased IL-10 production.	Poly I-C	30-37	tumor necrosis factor	Mus musculus	46-55
34656644-8	2022	Moreover, STING expression was time- and dose-dependently up-regulated by poly (I:C) and poly (dA:dT) treatments in Marc-145 cells.	Poly I-C	74-84	stimulator of interferon response cGAMP interactor 1	Homo sapiens	10-15
34454033-5	2022	Maoto significantly decreased PolyI:C-induced TNF-alpha levels and increased IL-10 production.	Poly I-C	30-37	interleukin 10	Mus musculus	77-82
34454033-7	2022	Furthermore, the inhibitory effects of maoto on PolyI:C-induced TNF-alpha production were not observed in ex vivo splenocytes, suggesting that maoto does not act directly on inflammatory cells.	Poly I-C	48-55	tumor necrosis factor	Mus musculus	64-73
34937041-6	2021	The aim of this study was to investigate the expression of ZAP in cultured hCMEC/D3 human brain microvascular endothelial cells treated with an authentic TLR3 agonist polyinosinic-polycytidylic acid (poly IC).	Poly I-C	167-198	toll like receptor 3	Homo sapiens	154-158
34906906-8	2022	Additionally, TAL combined with Poly I:C or CpG-ODN more increased TLR3, TLR9 and IRF7 protein levels in HCC1937 cells and treatment with TAL and Poly I:C had greater potential for overcoming TAL resistance.	Poly I-C	32-40	toll like receptor 3	Homo sapiens	67-71
34906906-8	2022	Additionally, TAL combined with Poly I:C or CpG-ODN more increased TLR3, TLR9 and IRF7 protein levels in HCC1937 cells and treatment with TAL and Poly I:C had greater potential for overcoming TAL resistance.	Poly I-C	32-40	toll like receptor 9	Homo sapiens	73-77
34906906-8	2022	Additionally, TAL combined with Poly I:C or CpG-ODN more increased TLR3, TLR9 and IRF7 protein levels in HCC1937 cells and treatment with TAL and Poly I:C had greater potential for overcoming TAL resistance.	Poly I-C	32-40	interferon regulatory factor 7	Homo sapiens	82-86
34964709-5	2021	Impaired macroautophagy/autophagy and reduced TNF/TNFalpha production was demonstrated in HEK293 cells transfected with TLR3L412F-encoding plasmid and stimulated with specific agonist poly(I:C).	Poly I-C	184-193	tumor necrosis factor	Homo sapiens	46-58
34952919-5	2021	Similarly, in mice transfected with E protein and treated with poly(I:C) to simulate the effects of viral RNA, the E protein, in an NLRP3-dependent fashion, reduced expression of pro-IL-1beta, levels of IL-1beta and IL-18 in broncho-alveolar lavage fluid, and macrophage infiltration in the lung.	Poly I-C	63-72	interleukin 1 alpha	Mus musculus	203-211
34952919-5	2021	Similarly, in mice transfected with E protein and treated with poly(I:C) to simulate the effects of viral RNA, the E protein, in an NLRP3-dependent fashion, reduced expression of pro-IL-1beta, levels of IL-1beta and IL-18 in broncho-alveolar lavage fluid, and macrophage infiltration in the lung.	Poly I-C	63-72	interleukin 18	Mus musculus	216-221
34935145-3	2022	Here, we evaluated the impact of the combination of 2 3 -c diAM(PS)2 and Poly I:C as potential adjuvants capable of potentiating DC s abilities to induce polyfunctional HIV-1 specific CD8+ T cell responses in vitro and in vivo using a humanized BLT mouse model.	Poly I-C	73-81	CD8a molecule	Homo sapiens	184-187
34937041-6	2021	The aim of this study was to investigate the expression of ZAP in cultured hCMEC/D3 human brain microvascular endothelial cells treated with an authentic TLR3 agonist polyinosinic-polycytidylic acid (poly IC).	Poly I-C	200-207	toll like receptor 3	Homo sapiens	154-158
34916261-5	2021	Bronchial epithelial cells (BECs) were expanded and stimulated with the viral replication mimic poly (I:C) (TLR3 agonist) in vitro.	Poly I-C	96-106	toll like receptor 3	Homo sapiens	108-112
34949739-2	2022	In macrophages, necroptosis can be induced by co-treatment with Toll-like receptor (TLR) ligands (lipopolysaccharide (LPS) for TLR4 and polyinosinic-polycytidylic acid (poly I:C) for TLR3) and a cell-permeable pan-caspase inhibitor zVAD.	Poly I-C	169-177	toll like receptor 3	Homo sapiens	183-187
34943274-5	2021	ELVs from poly (I:C)-stimulated airway cell culture medium were isolated by precipitation, visualised by transmission electron microscopy, and evaluated by nanoparticle analyser; exosomal markers CD81 and CD9 were determined by ELISA.	Poly I-C	10-20	Cd81 molecule	Rattus norvegicus	196-200
34943274-5	2021	ELVs from poly (I:C)-stimulated airway cell culture medium were isolated by precipitation, visualised by transmission electron microscopy, and evaluated by nanoparticle analyser; exosomal markers CD81 and CD9 were determined by ELISA.	Poly I-C	10-20	CD9 molecule	Rattus norvegicus	205-208
34916261-7	2021	RESULTS: Patients with atopic asthma had increased induction of IL-4, IFN-beta, IL-6, TNF-alpha, and IL-1beta after poly (I:C) stimulation compared to non-atopic patients, whereas in patients with eosinophilic asthma only IL-6 and IL-8 induction was higher than in non-eosinophilic asthma.	Poly I-C	116-126	interleukin 4	Homo sapiens	64-68
34916261-7	2021	RESULTS: Patients with atopic asthma had increased induction of IL-4, IFN-beta, IL-6, TNF-alpha, and IL-1beta after poly (I:C) stimulation compared to non-atopic patients, whereas in patients with eosinophilic asthma only IL-6 and IL-8 induction was higher than in non-eosinophilic asthma.	Poly I-C	116-126	IFN1@	Homo sapiens	70-78
34916261-7	2021	RESULTS: Patients with atopic asthma had increased induction of IL-4, IFN-beta, IL-6, TNF-alpha, and IL-1beta after poly (I:C) stimulation compared to non-atopic patients, whereas in patients with eosinophilic asthma only IL-6 and IL-8 induction was higher than in non-eosinophilic asthma.	Poly I-C	116-126	interleukin 6	Homo sapiens	80-84
34916261-7	2021	RESULTS: Patients with atopic asthma had increased induction of IL-4, IFN-beta, IL-6, TNF-alpha, and IL-1beta after poly (I:C) stimulation compared to non-atopic patients, whereas in patients with eosinophilic asthma only IL-6 and IL-8 induction was higher than in non-eosinophilic asthma.	Poly I-C	116-126	tumor necrosis factor	Homo sapiens	86-95
34916261-7	2021	RESULTS: Patients with atopic asthma had increased induction of IL-4, IFN-beta, IL-6, TNF-alpha, and IL-1beta after poly (I:C) stimulation compared to non-atopic patients, whereas in patients with eosinophilic asthma only IL-6 and IL-8 induction was higher than in non-eosinophilic asthma.	Poly I-C	116-126	interleukin 1 alpha	Homo sapiens	101-109
34916261-9	2021	Furthermore, induction of IL-33 in response to poly (I:C) was increased in severe atopic and in severe eosinophilic asthma, but TSLP only in severe eosinophilic asthma.	Poly I-C	47-57	interleukin 33	Homo sapiens	26-31
34897916-0	2022	PolyI:C attenuates TGF-beta signaling to induce cytostasis of surrounding cells by secreted factors in triple-negative breast cancer.	Poly I-C	0-7	transforming growth factor alpha	Homo sapiens	19-27
34755645-5	2021	Mechanistically, indoprofen potently inhibited the release of HMGB1 following stimulation by lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C), and suppressed recombinant human HMGB1(rhHMGB1)-induced inflammatory responses.	Poly I-C	154-162	high mobility group box 1	Homo sapiens	62-67
34903784-5	2021	In this study, in pregnant mice, we compare directly the effects, on the maternal blood, placenta and the embryonic brain, of maternal administration of ds-virus mimetic poly I:C (to activate Toll-like receptor 3, TLR3) and ss-virus mimetic resiquimod (to activate TLR7/8).	Poly I-C	170-178	toll-like receptor 3	Mus musculus	192-212
34903784-5	2021	In this study, in pregnant mice, we compare directly the effects, on the maternal blood, placenta and the embryonic brain, of maternal administration of ds-virus mimetic poly I:C (to activate Toll-like receptor 3, TLR3) and ss-virus mimetic resiquimod (to activate TLR7/8).	Poly I-C	170-178	toll-like receptor 3	Mus musculus	214-218
34903784-6	2021	We find that, 4 h after the administration, both poly I:C and resiquimod elevated the levels of IL-6, TNFalpha, and chemokines including CCL2 and CCL5, in maternal plasma.	Poly I-C	49-57	interleukin 6	Mus musculus	96-100
34903784-6	2021	We find that, 4 h after the administration, both poly I:C and resiquimod elevated the levels of IL-6, TNFalpha, and chemokines including CCL2 and CCL5, in maternal plasma.	Poly I-C	49-57	tumor necrosis factor	Mus musculus	102-110
34903784-6	2021	We find that, 4 h after the administration, both poly I:C and resiquimod elevated the levels of IL-6, TNFalpha, and chemokines including CCL2 and CCL5, in maternal plasma.	Poly I-C	49-57	chemokine (C-C motif) ligand 2	Mus musculus	137-141
34903784-6	2021	We find that, 4 h after the administration, both poly I:C and resiquimod elevated the levels of IL-6, TNFalpha, and chemokines including CCL2 and CCL5, in maternal plasma.	Poly I-C	49-57	chemokine (C-C motif) ligand 5	Mus musculus	146-150
34903784-8	2021	In foetal brain, poly I:C produced no detectable immune-response-related increases, whereas pronounced increases in cytokine (e.g. Il-6, Tnfalpha) and chemokine (e.g. Ccl2, Ccl5) expression were observed with maternal resiquimod administration.	Poly I-C	17-25	tumor necrosis factor	Mus musculus	137-145
34903784-8	2021	In foetal brain, poly I:C produced no detectable immune-response-related increases, whereas pronounced increases in cytokine (e.g. Il-6, Tnfalpha) and chemokine (e.g. Ccl2, Ccl5) expression were observed with maternal resiquimod administration.	Poly I-C	17-25	chemokine (C-C motif) ligand 2	Mus musculus	167-171
34903784-8	2021	In foetal brain, poly I:C produced no detectable immune-response-related increases, whereas pronounced increases in cytokine (e.g. Il-6, Tnfalpha) and chemokine (e.g. Ccl2, Ccl5) expression were observed with maternal resiquimod administration.	Poly I-C	17-25	chemokine (C-C motif) ligand 5	Mus musculus	173-177
34975898-7	2021	RV infection or poly(I:C) treatment induced chemokine secretion which were attenuated by blocking the action of ephA2 with ephA2 siRNA or inhibitor.	Poly I-C	16-25	EPH receptor A2	Homo sapiens	112-117
34975898-7	2021	RV infection or poly(I:C) treatment induced chemokine secretion which were attenuated by blocking the action of ephA2 with ephA2 siRNA or inhibitor.	Poly I-C	16-25	EPH receptor A2	Homo sapiens	123-128
34897916-5	2022	This study showed that transfection of a typical RLR ligand polyI:C in cancer cells produces significant levels of IFN-beta, which inhibits the growth of the surrounding cancer cells.	Poly I-C	60-67	DExH-box helicase 58	Homo sapiens	49-52
34897916-5	2022	This study showed that transfection of a typical RLR ligand polyI:C in cancer cells produces significant levels of IFN-beta, which inhibits the growth of the surrounding cancer cells.	Poly I-C	60-67	IFN1@	Homo sapiens	115-123
34610453-8	2021	After LPS and Poly (I:C) stimulation, the mRNA transcripts of CgAIF1 in gills were significantly increased at 6 h and 24 h (5.79-fold, p < 0.001, and 21.96-fold compared to the control group, p < 0.05), respectively.	Poly I-C	14-24	allograft inflammatory factor 1	Crassostrea gigas	62-68
34950134-7	2021	Results: Imiquimod reduced ACE2 expression at baseline and after poly(I:C) stimulation.	Poly I-C	65-74	angiotensin converting enzyme 2	Homo sapiens	27-31
34950134-8	2021	Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1beta, IL-6, IL-8, and IL-33.	Poly I-C	23-32	interleukin 1 alpha	Homo sapiens	78-86
34950134-8	2021	Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1beta, IL-6, IL-8, and IL-33.	Poly I-C	23-32	interleukin 6	Homo sapiens	88-92
34950134-8	2021	Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1beta, IL-6, IL-8, and IL-33.	Poly I-C	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
34950134-8	2021	Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1beta, IL-6, IL-8, and IL-33.	Poly I-C	23-32	interleukin 33	Homo sapiens	104-109
34453520-6	2021	Poly(I:C) dramatically induced the expression of the pro-inflammatory cytokines TNF-alpha and IL-6 in SC and LC through Toll-like receptor 3 and IFN-beta promoter stimulator 1 signaling pathways, impairing the integrity of the blood-testis barrier and testosterone synthesis.	Poly I-C	0-9	tumor necrosis factor	Mus musculus	80-89
34453520-6	2021	Poly(I:C) dramatically induced the expression of the pro-inflammatory cytokines TNF-alpha and IL-6 in SC and LC through Toll-like receptor 3 and IFN-beta promoter stimulator 1 signaling pathways, impairing the integrity of the blood-testis barrier and testosterone synthesis.	Poly I-C	0-9	interleukin 6	Homo sapiens	94-98
34453520-6	2021	Poly(I:C) dramatically induced the expression of the pro-inflammatory cytokines TNF-alpha and IL-6 in SC and LC through Toll-like receptor 3 and IFN-beta promoter stimulator 1 signaling pathways, impairing the integrity of the blood-testis barrier and testosterone synthesis.	Poly I-C	0-9	toll like receptor 3	Homo sapiens	120-140
34453520-7	2021	Poly(I:C)-induced TNF-alpha production thus plays a critical role in the impairment of cell functions.	Poly I-C	0-9	tumor necrosis factor	Mus musculus	18-27
34956178-5	2021	Positive regulatory domain 1 (PRDM1) was induced by DENV or poly(I:C) and suppressed NLRP12 expression, which was dependent on TBK-1/IRF3 and NF-kappaB signaling pathways.	Poly I-C	60-69	PR/SET domain 1	Homo sapiens	30-35
34956178-5	2021	Positive regulatory domain 1 (PRDM1) was induced by DENV or poly(I:C) and suppressed NLRP12 expression, which was dependent on TBK-1/IRF3 and NF-kappaB signaling pathways.	Poly I-C	60-69	NLR family pyrin domain containing 12	Homo sapiens	85-91
34956178-5	2021	Positive regulatory domain 1 (PRDM1) was induced by DENV or poly(I:C) and suppressed NLRP12 expression, which was dependent on TBK-1/IRF3 and NF-kappaB signaling pathways.	Poly I-C	60-69	TANK binding kinase 1	Homo sapiens	127-132
34956178-5	2021	Positive regulatory domain 1 (PRDM1) was induced by DENV or poly(I:C) and suppressed NLRP12 expression, which was dependent on TBK-1/IRF3 and NF-kappaB signaling pathways.	Poly I-C	60-69	interferon regulatory factor 3	Homo sapiens	133-137
34726731-4	2021	Their fibroblasts respond poorly to extracellular (TLR3) or intracellular (MDA5) poly(I:C) stimulation.	Poly I-C	81-90	interferon induced with helicase C domain 1	Homo sapiens	75-79
34899052-7	2021	Results: After Poly I:C stimulation, IL-35 inhibited the production of IL-25, and TSLP from HNECs increased significantly compared with baseline levels (P < 0.05).	Poly I-C	15-23	interleukin 25	Mus musculus	71-76
34899052-7	2021	Results: After Poly I:C stimulation, IL-35 inhibited the production of IL-25, and TSLP from HNECs increased significantly compared with baseline levels (P < 0.05).	Poly I-C	15-23	thymic stromal lymphopoietin	Mus musculus	82-86
34274364-7	2021	Furthermore, knockdown of endogenous duIKKbeta significantly reduced LPS-, poly(I:C)- or SeV-induced NF-kappaB activation.	Poly I-C	75-84	nuclear factor kappa B subunit 1	Homo sapiens	101-110
34925374-7	2021	In addition, the effect of PAR2 activation on polyinosinic-polycytidylic acid (poly I:C) activation of TLR3 was analyzed in bone marrow-derived macrophages (BMDM).	Poly I-C	46-77	toll-like receptor 3	Mus musculus	103-107
34925374-7	2021	In addition, the effect of PAR2 activation on polyinosinic-polycytidylic acid (poly I:C) activation of TLR3 was analyzed in bone marrow-derived macrophages (BMDM).	Poly I-C	79-87	toll-like receptor 3	Mus musculus	103-107
34925374-12	2021	In vitro studies showed that Par2-/- BMDM produced less IL6 and IL12p40 than Par2 +/+ BMDM after poly I:C stimulation.	Poly I-C	97-105	F2R like trypsin receptor 1	Homo sapiens	29-33
34925374-12	2021	In vitro studies showed that Par2-/- BMDM produced less IL6 and IL12p40 than Par2 +/+ BMDM after poly I:C stimulation.	Poly I-C	97-105	interleukin 6	Homo sapiens	56-59
34925374-13	2021	In addition, activation of PAR2 on Par2 +/+ BMDM increased poly I:C induction of IL6 and IL12p40 compared to poly I:C stimulation alone.	Poly I-C	59-67	F2R like trypsin receptor 1	Homo sapiens	27-31
34925374-13	2021	In addition, activation of PAR2 on Par2 +/+ BMDM increased poly I:C induction of IL6 and IL12p40 compared to poly I:C stimulation alone.	Poly I-C	59-67	F2R like trypsin receptor 1	Homo sapiens	35-39
34925374-13	2021	In addition, activation of PAR2 on Par2 +/+ BMDM increased poly I:C induction of IL6 and IL12p40 compared to poly I:C stimulation alone.	Poly I-C	59-67	interleukin 6	Homo sapiens	81-84
34610453-9	2021	In immunocytochemical assay, the CgAIF1 positive signals were mainly distributed in the cytoplasm of haemocytes, while after Poly (I:C) stimulation, the increased CgAIF1 positive signals were observed in the nucleus.	Poly I-C	125-135	allograft inflammatory factor 1	Crassostrea gigas	33-39
34610453-9	2021	In immunocytochemical assay, the CgAIF1 positive signals were mainly distributed in the cytoplasm of haemocytes, while after Poly (I:C) stimulation, the increased CgAIF1 positive signals were observed in the nucleus.	Poly I-C	125-135	allograft inflammatory factor 1	Crassostrea gigas	163-169
34826050-4	2022	In this context, we for the first time assessed the immunotherapeutic role of CAB in the TLR3 signalling following activation of Poly I:C in mCRPC cells.	Poly I-C	129-137	toll like receptor 3	Homo sapiens	89-93
34931614-10	2021	Besides, poly(I:C)/advax formulated PfMSP-142 induced a higher ratio of IFN-gamma/IL-4 (25.33) and IgG2a/IgG1 (1.89) when compared with poly(I:C) alone.	Poly I-C	9-18	interferon gamma	Mus musculus	72-81
34931614-10	2021	Besides, poly(I:C)/advax formulated PfMSP-142 induced a higher ratio of IFN-gamma/IL-4 (25.33) and IgG2a/IgG1 (1.89) when compared with poly(I:C) alone.	Poly I-C	9-18	interleukin 4	Mus musculus	82-86
34931614-10	2021	Besides, poly(I:C)/advax formulated PfMSP-142 induced a higher ratio of IFN-gamma/IL-4 (25.33) and IgG2a/IgG1 (1.89) when compared with poly(I:C) alone.	Poly I-C	9-18	immunoglobulin heavy variable V1-9	Mus musculus	99-104
34931614-10	2021	Besides, poly(I:C)/advax formulated PfMSP-142 induced a higher ratio of IFN-gamma/IL-4 (25.33) and IgG2a/IgG1 (1.89) when compared with poly(I:C) alone.	Poly I-C	9-18	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	105-109
34931614-10	2021	Besides, poly(I:C)/advax formulated PfMSP-142 induced a higher ratio of IFN-gamma/IL-4 (25.33) and IgG2a/IgG1 (1.89) when compared with poly(I:C) alone.	Poly I-C	136-145	interferon gamma	Mus musculus	72-81
34931614-10	2021	Besides, poly(I:C)/advax formulated PfMSP-142 induced a higher ratio of IFN-gamma/IL-4 (25.33) and IgG2a/IgG1 (1.89) when compared with poly(I:C) alone.	Poly I-C	136-145	interleukin 4	Mus musculus	82-86
34931614-10	2021	Besides, poly(I:C)/advax formulated PfMSP-142 induced a higher ratio of IFN-gamma/IL-4 (25.33) and IgG2a/IgG1 (1.89) when compared with poly(I:C) alone.	Poly I-C	136-145	immunoglobulin heavy variable V1-9	Mus musculus	99-104
34931614-10	2021	Besides, poly(I:C)/advax formulated PfMSP-142 induced a higher ratio of IFN-gamma/IL-4 (25.33) and IgG2a/IgG1 (1.89) when compared with poly(I:C) alone.	Poly I-C	136-145	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	105-109
34293939-4	2021	In the first age-appropriate model for childhood arteriopathy-by administration of viral mimetic TLR3-agonist Polyinosinic:polycytidylic acid (Poly-IC) in juvenile mice-we identified a key role of the TLR3-neutrophil axis in disrupting the structural-functional integrity of the blood-brain barrier (BBB) and distorting the developing neurovascular architecture and vascular networks.	Poly I-C	143-150	toll-like receptor 3	Mus musculus	97-101
34293939-4	2021	In the first age-appropriate model for childhood arteriopathy-by administration of viral mimetic TLR3-agonist Polyinosinic:polycytidylic acid (Poly-IC) in juvenile mice-we identified a key role of the TLR3-neutrophil axis in disrupting the structural-functional integrity of the blood-brain barrier (BBB) and distorting the developing neurovascular architecture and vascular networks.	Poly I-C	143-150	toll-like receptor 3	Mus musculus	201-205
34293939-6	2021	Poly-IC also enhanced the neuroinflammatory milieu, promoted neutrophil recruitment, profoundly upregulated neutrophil elastase (NE), and induced neutrophil extracellular trap formation (NETosis).	Poly I-C	0-7	elastase, neutrophil expressed	Homo sapiens	108-127
33820486-3	2021	METHODS: We examined the effect of polyinosinic-polycytidylic acid (poly IC), an agonist of TLR3, on MCP-1, CCL5 and interferon (IFN)-beta expression in GECs.	Poly I-C	35-66	toll like receptor 3	Homo sapiens	92-96
33820486-3	2021	METHODS: We examined the effect of polyinosinic-polycytidylic acid (poly IC), an agonist of TLR3, on MCP-1, CCL5 and interferon (IFN)-beta expression in GECs.	Poly I-C	35-66	C-C motif chemokine ligand 2	Homo sapiens	101-106
33820486-3	2021	METHODS: We examined the effect of polyinosinic-polycytidylic acid (poly IC), an agonist of TLR3, on MCP-1, CCL5 and interferon (IFN)-beta expression in GECs.	Poly I-C	35-66	C-C motif chemokine ligand 5	Homo sapiens	108-112
33820486-3	2021	METHODS: We examined the effect of polyinosinic-polycytidylic acid (poly IC), an agonist of TLR3, on MCP-1, CCL5 and interferon (IFN)-beta expression in GECs.	Poly I-C	35-66	IFN1@	Homo sapiens	117-138
33820486-3	2021	METHODS: We examined the effect of polyinosinic-polycytidylic acid (poly IC), an agonist of TLR3, on MCP-1, CCL5 and interferon (IFN)-beta expression in GECs.	Poly I-C	68-75	toll like receptor 3	Homo sapiens	92-96
33820486-3	2021	METHODS: We examined the effect of polyinosinic-polycytidylic acid (poly IC), an agonist of TLR3, on MCP-1, CCL5 and interferon (IFN)-beta expression in GECs.	Poly I-C	68-75	C-C motif chemokine ligand 2	Homo sapiens	101-106
33820486-3	2021	METHODS: We examined the effect of polyinosinic-polycytidylic acid (poly IC), an agonist of TLR3, on MCP-1, CCL5 and interferon (IFN)-beta expression in GECs.	Poly I-C	68-75	C-C motif chemokine ligand 5	Homo sapiens	108-112
33820486-3	2021	METHODS: We examined the effect of polyinosinic-polycytidylic acid (poly IC), an agonist of TLR3, on MCP-1, CCL5 and interferon (IFN)-beta expression in GECs.	Poly I-C	68-75	IFN1@	Homo sapiens	117-138
34821951-6	2021	We evaluated several TLR ligand combinations and demonstrated that polyinosinic:polycytidylic acid (poly(I:C)) and R848, ligands for TLR3 and TLR7/8, respectively, constituted the optimal combination for inducing a positive co-stimulatory profile in all BDC subsets.	Poly I-C	100-109	toll like receptor 3	Homo sapiens	133-137
34821951-6	2021	We evaluated several TLR ligand combinations and demonstrated that polyinosinic:polycytidylic acid (poly(I:C)) and R848, ligands for TLR3 and TLR7/8, respectively, constituted the optimal combination for inducing a positive co-stimulatory profile in all BDC subsets.	Poly I-C	100-109	toll like receptor 7	Homo sapiens	142-148
34826050-5	2022	METHODS AND RESULTS: The cytotoxic and apoptotic effects of CAB with the induction of Poly I:C were determined by WST-1, Annexin V, acridine orange, RT-PCR analysis, ELISA assay and immunofluorescence staining in DU-145 mCRPC and HUVEC control cells.	Poly I-C	86-94	annexin A5	Homo sapiens	121-130
34739556-5	2022	To examine the role of SMPDL3b in TLR3 signaling in podocytes, we treated conditionally immortalized human podocytes with polyinosinic-polycytidylic acid (poly IC), to activate TLR3 signaling.	Poly I-C	122-153	toll like receptor 3	Homo sapiens	177-181
34582376-5	2021	On the contrary, mascRNA potentiated the phosphorylation of IRF3 and STAT1 and the transcription of interferon-related genes in response to the TLR3 ligand poly(I:C) both in vitro and in vivo.	Poly I-C	156-165	interferon regulatory factor 3	Homo sapiens	60-64
34582376-5	2021	On the contrary, mascRNA potentiated the phosphorylation of IRF3 and STAT1 and the transcription of interferon-related genes in response to the TLR3 ligand poly(I:C) both in vitro and in vivo.	Poly I-C	156-165	signal transducer and activator of transcription 1	Homo sapiens	69-74
34582376-5	2021	On the contrary, mascRNA potentiated the phosphorylation of IRF3 and STAT1 and the transcription of interferon-related genes in response to the TLR3 ligand poly(I:C) both in vitro and in vivo.	Poly I-C	156-165	toll like receptor 3	Homo sapiens	144-148
34901066-6	2021	After the addition of the PI3K inhibitor, the mRNA expression and protein secretion of indoleamine 2,3-dioxygenase 1 and heme oxygenase 1 of various mesenchymal stem cells were significantly reduced, and that of mesenchymal stem cells treated with poly(I:C) (anti-inflammatory phenotype) was more obvious.	Poly I-C	248-257	indoleamine 2,3-dioxygenase 1	Mus musculus	87-116
34901066-6	2021	After the addition of the PI3K inhibitor, the mRNA expression and protein secretion of indoleamine 2,3-dioxygenase 1 and heme oxygenase 1 of various mesenchymal stem cells were significantly reduced, and that of mesenchymal stem cells treated with poly(I:C) (anti-inflammatory phenotype) was more obvious.	Poly I-C	248-257	heme oxygenase 1	Mus musculus	121-137
34901066-8	2021	Anti-inflammatory mesenchymal stem cells induced by poly(I:C) can better protect renal function, alleviate tissue damage, reduce circulating inflammation levels and enhance antioxidant capacity, and achieve stronger anti-inflammatory effects through the TLR3/PI3K pathway.	Poly I-C	52-61	toll-like receptor 3	Mus musculus	254-258
34734602-2	2021	Hit molecules sensitized the IRF3-mediated antiviral mechanism in the presence of poly(I:C) and inhibited the replication of SARS-CoV-2 by inducing stress granule formation.	Poly I-C	82-91	interferon regulatory factor 3	Homo sapiens	29-33
34832320-7	2021	Similarly, when RAW 264.7 macrophages were incubated with other agonists of Toll-like receptor (TLR) signaling e.g., FSL1, Polyinosinic-polycytidylic acid High Molecular Weight (Poly (1:C) HMW), Pam3CSK4, and imiquimod, ADL reduced the IL6 expression.	Poly I-C	123-154	interleukin 6	Mus musculus	236-239
34766215-2	2021	In our study, AddaVax and PolyI:C combined adjuvant (AP adjuvant) were used for influenza vaccine development.	Poly I-C	26-33	LIM homeobox protein 2	Mus musculus	53-55
34805408-6	2021	The perforin levels in NK cells were similar between the poly(I:C)-treated CB17/SCID and NOD/SCID mice, while the granzyme B and NKG2A/C/E levels in NK cells from NOD/SCID mice were significantly lower than those from CB17/SCID mice.	Poly I-C	57-66	granzyme B	Mus musculus	114-124
34805408-6	2021	The perforin levels in NK cells were similar between the poly(I:C)-treated CB17/SCID and NOD/SCID mice, while the granzyme B and NKG2A/C/E levels in NK cells from NOD/SCID mice were significantly lower than those from CB17/SCID mice.	Poly I-C	57-66	killer cell lectin-like receptor subfamily C, member 1	Mus musculus	129-134
34758338-5	2021	The STAT3-RGS4 pathway was also activated in neonatal brains during poly(I:C)-induced maternal immune activation, which mimics viral infection during pregnancy.	Poly I-C	68-77	signal transducer and activator of transcription 3	Mus musculus	4-9
34758338-5	2021	The STAT3-RGS4 pathway was also activated in neonatal brains during poly(I:C)-induced maternal immune activation, which mimics viral infection during pregnancy.	Poly I-C	68-77	regulator of G-protein signaling 4	Mus musculus	10-14
34739556-5	2022	To examine the role of SMPDL3b in TLR3 signaling in podocytes, we treated conditionally immortalized human podocytes with polyinosinic-polycytidylic acid (poly IC), to activate TLR3 signaling.	Poly I-C	155-162	toll like receptor 3	Homo sapiens	177-181
34261013-5	2021	Significantly elevated plasma levels of IL-6, TNF-alpha and IL-17A assessed after 24 hours were observed in both the poly (I:C) and LPS-treated rats, while IL-1beta was only elevated in LPS-treated rats, indicating MIA.	Poly I-C	117-127	interleukin 6	Rattus norvegicus	40-44
34727942-0	2021	Correction to: A formulated poly (I:C)/CCL21 as an effective mucosal adjuvant for gamma-irradiated influenza vaccine.	Poly I-C	28-38	C-C motif chemokine ligand 21	Homo sapiens	39-44
34261013-5	2021	Significantly elevated plasma levels of IL-6, TNF-alpha and IL-17A assessed after 24 hours were observed in both the poly (I:C) and LPS-treated rats, while IL-1beta was only elevated in LPS-treated rats, indicating MIA.	Poly I-C	117-127	tumor necrosis factor	Rattus norvegicus	46-55
34261013-5	2021	Significantly elevated plasma levels of IL-6, TNF-alpha and IL-17A assessed after 24 hours were observed in both the poly (I:C) and LPS-treated rats, while IL-1beta was only elevated in LPS-treated rats, indicating MIA.	Poly I-C	117-127	interleukin 17A	Rattus norvegicus	60-66
34454292-7	2021	DSCs were cultured in the presence or absence of the TLR2 agonists PAM3CSK4, PGN-Sa, and zymosan, the TLR3 agonist poly (I:C) and the TLR4 agonist LPS.	Poly I-C	115-125	toll like receptor 3	Homo sapiens	102-106
34591979-1	2021	Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA (or the synthetic dsRNA analog poly I:C) and induces a signal transduction pathway that results in activation of transcription factors that induce expression of antiviral genes including type I interferon (IFN-I).	Poly I-C	96-104	toll like receptor 3	Homo sapiens	0-20
34591979-1	2021	Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA (or the synthetic dsRNA analog poly I:C) and induces a signal transduction pathway that results in activation of transcription factors that induce expression of antiviral genes including type I interferon (IFN-I).	Poly I-C	96-104	toll like receptor 3	Homo sapiens	22-26
34643794-14	2022	In addition, bevacizumab reduced the secretion of IL-8 and TNFalpha after Poly I:C stimulation at selected time points.	Poly I-C	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
34696514-5	2021	An in vitro model of infection with Poly(I:C), a synthetic analog of viral double-stranded RNA, triggered NF-kappaB activation, an effect that was halted by IVM and ATV treatment.	Poly I-C	36-45	nuclear factor kappa B subunit 1	Homo sapiens	106-115
34505627-4	2021	We found that tMSCs expressed TSP-1 and Poly (I: C) or LPS treatment promoted the expression of TSP-1.	Poly I-C	40-51	thrombospondin 1	Homo sapiens	96-101
34693552-5	2022	Upon challenge with the immunostimulant polyinosinic:polycytidylic acid (poly(I:C)), NK cells isolated from Hpse-/- mice displayed impaired cytotoxicity against EO771.LMB cells and reduced levels of activation markers CD69 and NKG2D.	Poly I-C	73-82	heparanase	Mus musculus	108-112
34693552-5	2022	Upon challenge with the immunostimulant polyinosinic:polycytidylic acid (poly(I:C)), NK cells isolated from Hpse-/- mice displayed impaired cytotoxicity against EO771.LMB cells and reduced levels of activation markers CD69 and NKG2D.	Poly I-C	73-82	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	227-232
34693552-8	2022	Poly(I:C)-stimulated Hpse-/- bone marrow DCs (BMDCs) expressed less IL-12, and when cultured with Hpse-/- NK cells, less MCP-1 mRNA and protein was detected.	Poly I-C	0-9	heparanase	Mus musculus	21-25
34693552-8	2022	Poly(I:C)-stimulated Hpse-/- bone marrow DCs (BMDCs) expressed less IL-12, and when cultured with Hpse-/- NK cells, less MCP-1 mRNA and protein was detected.	Poly I-C	0-9	mast cell protease 1	Mus musculus	121-126
34643794-14	2022	In addition, bevacizumab reduced the secretion of IL-8 and TNFalpha after Poly I:C stimulation at selected time points.	Poly I-C	74-82	tumor necrosis factor	Homo sapiens	59-67
34643794-15	2022	CONCLUSIONS: Pro-inflammatory activation of RPE cells with TLR-3 agonist Poly I:C changes the interaction of RPE cells with the anti-VEGF compound bevacizumab, reducing its uptake and transport.	Poly I-C	73-81	toll like receptor 3	Homo sapiens	59-64
34643794-15	2022	CONCLUSIONS: Pro-inflammatory activation of RPE cells with TLR-3 agonist Poly I:C changes the interaction of RPE cells with the anti-VEGF compound bevacizumab, reducing its uptake and transport.	Poly I-C	73-81	vascular endothelial growth factor A	Homo sapiens	133-137
34665110-8	2021	Further, polyI:C stimulation of bone marrow-derived macrophages (BMDMs) induced TNF-alpha, IFN-beta, IL-6 and Nos-2, but responses were not different in BMDMs generated from WT or vip-/- mice.	Poly I-C	9-16	tumor necrosis factor	Mus musculus	80-89
34691085-3	2021	Poly I:C, a potent TLR3 ligand, licenses cross-presenting dendritic cells (DC1) to accelerate a robust cytotoxic T cells response against a foreign antigen.	Poly I-C	0-8	toll-like receptor 3	Mus musculus	19-23
34691085-10	2021	In a metastatic melanoma model, we show that a triple-combination prophylactic treatment consisting of anti-IL-10, tumor peptides and Poly I:C works because removing IL-10 counteracts the monocytic brake, resulting in significantly fewer tumors compared to mice treated with tumor peptides and Poly I:C alone.	Poly I-C	134-142	interleukin 10	Mus musculus	166-171
34691085-10	2021	In a metastatic melanoma model, we show that a triple-combination prophylactic treatment consisting of anti-IL-10, tumor peptides and Poly I:C works because removing IL-10 counteracts the monocytic brake, resulting in significantly fewer tumors compared to mice treated with tumor peptides and Poly I:C alone.	Poly I-C	294-302	interleukin 10	Mus musculus	108-113
34303791-2	2021	Polyinosinic:polycytidylic acid (PIC) is a Toll-like receptor 3 (TLR3) agonist that induces tumor cells apoptosis after activation.	Poly I-C	33-36	toll like receptor 3	Homo sapiens	43-63
34303791-2	2021	Polyinosinic:polycytidylic acid (PIC) is a Toll-like receptor 3 (TLR3) agonist that induces tumor cells apoptosis after activation.	Poly I-C	33-36	toll like receptor 3	Homo sapiens	65-69
34627297-0	2021	A formulated poly (I:C)/CCL21 as an effective mucosal adjuvant for gamma-irradiated influenza vaccine.	Poly I-C	13-23	C-C motif chemokine ligand 21	Homo sapiens	24-29
34729315-4	2021	To obtain a proof-of-concept, a co-delivery system was prepared via a drug-delivering-drug (DDD) strategy for cytosolic co-delivery of Poly I:C, a synthetic dsRNA analog to activate RIG-I signaling, and PTX, a commonly used chemotherapeutics, in which pure PTX nanorods were sequentially coated with Poly I:C and mannuronic acid via stimulating the RIG-I signaling axis.	Poly I-C	300-308	DExD/H-box helicase 58	Homo sapiens	349-354
34665110-8	2021	Further, polyI:C stimulation of bone marrow-derived macrophages (BMDMs) induced TNF-alpha, IFN-beta, IL-6 and Nos-2, but responses were not different in BMDMs generated from WT or vip-/- mice.	Poly I-C	9-16	interferon alpha	Mus musculus	91-99
34665110-8	2021	Further, polyI:C stimulation of bone marrow-derived macrophages (BMDMs) induced TNF-alpha, IFN-beta, IL-6 and Nos-2, but responses were not different in BMDMs generated from WT or vip-/- mice.	Poly I-C	9-16	interleukin 6	Mus musculus	101-105
34665110-8	2021	Further, polyI:C stimulation of bone marrow-derived macrophages (BMDMs) induced TNF-alpha, IFN-beta, IL-6 and Nos-2, but responses were not different in BMDMs generated from WT or vip-/- mice.	Poly I-C	9-16	nitric oxide synthase 2, inducible	Mus musculus	110-115
34703822-10	2021	NAC suppressed TNF-alpha- or poly (I:C)-induced expression of MCP-1 and CX3CL1.	Poly I-C	29-39	C-C motif chemokine ligand 2	Rattus norvegicus	62-67
34703822-9	2021	Increased intracellular and mitochondrial ROS accumulation, cytokine expression, MMP disruption, and NF-kappaB activation were all prevented by DHA in TNF-alpha- or poly (I:C)-treated PSCs.	Poly I-C	165-175	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-110
34703822-10	2021	NAC suppressed TNF-alpha- or poly (I:C)-induced expression of MCP-1 and CX3CL1.	Poly I-C	29-39	C-X3-C motif chemokine ligand 1	Rattus norvegicus	72-78
34703822-11	2021	In conclusion, DHA inhibits poly (I:C)- or TNF-alpha-induced cytokine expression and NF-kappaB activation by reducing intracellular and mitochondrial ROS in PSCs.	Poly I-C	28-38	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	85-94
34630423-8	2021	The knockdown of chDDX1 increased the viral yield of NDV and VSV and decreased the production of IFN-beta, which was induced by RNA analog polyinosinic-polycytidylic acid (poly(I:C)), by AIV, and by NDV.	Poly I-C	139-170	IFN1@	Homo sapiens	97-105
34681079-7	2021	Expression of NOS2 in Poly I:C was an average fourfold above that of control at the same timepoint.	Poly I-C	22-30	nitric oxide synthase, inducible	Salmo salar	14-18
34282808-12	2021	ACE2 expression was suppressed in ENP tissues; however, a combination of poly(I:C) and IL-13 induced ACE2/TMPRSS2 upregulation in ENP.	Poly I-C	73-82	angiotensin converting enzyme 2	Homo sapiens	101-105
34282808-12	2021	ACE2 expression was suppressed in ENP tissues; however, a combination of poly(I:C) and IL-13 induced ACE2/TMPRSS2 upregulation in ENP.	Poly I-C	73-82	transmembrane serine protease 2	Homo sapiens	106-113
34630393-5	2021	Poly (I:C), a viral dsRNA mimic, potently increased secretion of IFNlambda1 by both epithelial cells and fibroblasts.	Poly I-C	0-10	interferon lambda 1	Homo sapiens	65-75
34630393-6	2021	The secretion of IFNlambda1 by epithelial cells significantly increased with increasing age following poly (I:C) stimulation.	Poly I-C	102-112	interferon lambda 1	Homo sapiens	17-27
34488804-7	2021	Only males showed increased IFNalpha and IFNgamma in response to poly I:C, whereas both males and females exhibited elevations of IFNbeta, demonstrating a specific sex difference in the anti-viral response in the hippocampus.	Poly I-C	65-73	interferon alpha	Mus musculus	28-36
34621188-7	2021	Immunohistochemical analysis of vagal sensory neurons collected from mice after intranasal infection with murine pneumovirus or influenza A virus (IAV), or after intratracheal administration with the viral mimetic PolyI:C, revealed a significant increase in nuclear-to-cytoplasm translocation of HMGB1 compared to mock-inoculated mice.	Poly I-C	214-221	high mobility group box 1	Homo sapiens	296-301
34571785-0	2021	Monophosphoryl Lipid A and Poly I:C Combination Adjuvant Promoted Ovalbumin-Specific Cell Mediated Immunity in Mice Model.	Poly I-C	27-35	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	66-75
34568076-0	2021	CD68+ Macrophage Infiltration Associates With Poor Outcome of HPV Negative Oral Squamous Carcinoma Patients Receiving Radiation: Poly(I:C) Enhances Radiosensitivity of CAL-27 Cells but Promotes Macrophage Recruitment Through HMGB1.	Poly I-C	129-138	CD68 molecule	Homo sapiens	0-4
34568076-0	2021	CD68+ Macrophage Infiltration Associates With Poor Outcome of HPV Negative Oral Squamous Carcinoma Patients Receiving Radiation: Poly(I:C) Enhances Radiosensitivity of CAL-27 Cells but Promotes Macrophage Recruitment Through HMGB1.	Poly I-C	129-138	high mobility group box 1	Homo sapiens	225-230
34564417-4	2021	Treatment with polyinosinic:polycytidylic acid (poly(I:C))-an agonist of TLR3-significantly suppressed intracellular bacterial growth by promoting intracellular ROS production in S. Typhimurium-infected cells.	Poly I-C	15-46	toll-like receptor 3	Mus musculus	73-77
34564417-4	2021	Treatment with polyinosinic:polycytidylic acid (poly(I:C))-an agonist of TLR3-significantly suppressed intracellular bacterial growth by promoting intracellular ROS production in S. Typhimurium-infected cells.	Poly I-C	48-57	toll-like receptor 3	Mus musculus	73-77
34488804-7	2021	Only males showed increased IFNalpha and IFNgamma in response to poly I:C, whereas both males and females exhibited elevations of IFNbeta, demonstrating a specific sex difference in the anti-viral response in the hippocampus.	Poly I-C	65-73	interferon gamma	Mus musculus	41-49
34524081-7	2021	In poly(I:C)-stimulated THP-1 cell and primary monocytes, MIAT upregulation coupled with THRIL downregulation was similar to the expression pattern observed in AOSD.	Poly I-C	3-12	myocardial infarction associated transcript	Homo sapiens	58-62
34427417-5	2021	Endosomal stimulation of TLR3 by adding poly(I:C) in cell culture media or cytoplasmic stimulation of MDA5 by transfecting poly(I:C) resulted in significant increases of TLR3, MDA5, interferon (IFN) beta, and interleukin 8 gene expression levels in wild type (WT) cells.	Poly I-C	40-49	toll like receptor 3	Homo sapiens	25-29
34427417-5	2021	Endosomal stimulation of TLR3 by adding poly(I:C) in cell culture media or cytoplasmic stimulation of MDA5 by transfecting poly(I:C) resulted in significant increases of TLR3, MDA5, interferon (IFN) beta, and interleukin 8 gene expression levels in wild type (WT) cells.	Poly I-C	40-49	toll like receptor 3	Homo sapiens	170-174
34427417-5	2021	Endosomal stimulation of TLR3 by adding poly(I:C) in cell culture media or cytoplasmic stimulation of MDA5 by transfecting poly(I:C) resulted in significant increases of TLR3, MDA5, interferon (IFN) beta, and interleukin 8 gene expression levels in wild type (WT) cells.	Poly I-C	40-49	interferon induced with helicase C domain 1	Homo sapiens	176-180
34524081-7	2021	In poly(I:C)-stimulated THP-1 cell and primary monocytes, MIAT upregulation coupled with THRIL downregulation was similar to the expression pattern observed in AOSD.	Poly I-C	3-12	TNF and HNRNPL related immunoregulatory long non-coding RNA	Homo sapiens	89-94
34390443-6	2021	By Western blotting, polyI:C dramatically decreased TGF-beta1-induced Ak strain transforming (Akt) phosphorylation and increased phosphatase and tensin homologue (PTEN) expression without affecting the Son of mothers against decapentaplegic (Smad) 3 phosphorylation or the expression level of E-cadherin, N-cadherin or Snail, indicating that polyI:C suppressed cell motility independently of the "cadherin switching".	Poly I-C	21-28	cadherin 1	Homo sapiens	397-405
34390443-0	2021	PolyI:C suppresses TGF-beta1-induced Akt phosphorylation and reduces the motility of A549 lung carcinoma cells.	Poly I-C	0-7	transforming growth factor beta 1	Homo sapiens	19-28
34390443-3	2021	Polyinosinic-polycytidylic acid (polyI:C), a synthetic agonist for toll-like receptor (TLR) 3, can enhance immune responses and has been used as an adjuvant for cancer vaccines; however, it remains unclear whether it influences other process, such as EMT.	Poly I-C	0-31	toll like receptor 3	Homo sapiens	67-93
34390443-3	2021	Polyinosinic-polycytidylic acid (polyI:C), a synthetic agonist for toll-like receptor (TLR) 3, can enhance immune responses and has been used as an adjuvant for cancer vaccines; however, it remains unclear whether it influences other process, such as EMT.	Poly I-C	33-40	toll like receptor 3	Homo sapiens	67-93
34390443-6	2021	By Western blotting, polyI:C dramatically decreased TGF-beta1-induced Ak strain transforming (Akt) phosphorylation and increased phosphatase and tensin homologue (PTEN) expression without affecting the Son of mothers against decapentaplegic (Smad) 3 phosphorylation or the expression level of E-cadherin, N-cadherin or Snail, indicating that polyI:C suppressed cell motility independently of the "cadherin switching".	Poly I-C	21-28	phosphatase and tensin homolog	Homo sapiens	129-161
34390443-6	2021	By Western blotting, polyI:C dramatically decreased TGF-beta1-induced Ak strain transforming (Akt) phosphorylation and increased phosphatase and tensin homologue (PTEN) expression without affecting the Son of mothers against decapentaplegic (Smad) 3 phosphorylation or the expression level of E-cadherin, N-cadherin or Snail, indicating that polyI:C suppressed cell motility independently of the "cadherin switching".	Poly I-C	21-28	phosphatase and tensin homolog	Homo sapiens	163-167
34390443-6	2021	By Western blotting, polyI:C dramatically decreased TGF-beta1-induced Ak strain transforming (Akt) phosphorylation and increased phosphatase and tensin homologue (PTEN) expression without affecting the Son of mothers against decapentaplegic (Smad) 3 phosphorylation or the expression level of E-cadherin, N-cadherin or Snail, indicating that polyI:C suppressed cell motility independently of the "cadherin switching".	Poly I-C	21-28	cadherin 2	Homo sapiens	305-315
34390443-6	2021	By Western blotting, polyI:C dramatically decreased TGF-beta1-induced Ak strain transforming (Akt) phosphorylation and increased phosphatase and tensin homologue (PTEN) expression without affecting the Son of mothers against decapentaplegic (Smad) 3 phosphorylation or the expression level of E-cadherin, N-cadherin or Snail, indicating that polyI:C suppressed cell motility independently of the "cadherin switching".	Poly I-C	342-349	transforming growth factor beta 1	Homo sapiens	52-61
34390443-6	2021	By Western blotting, polyI:C dramatically decreased TGF-beta1-induced Ak strain transforming (Akt) phosphorylation and increased phosphatase and tensin homologue (PTEN) expression without affecting the Son of mothers against decapentaplegic (Smad) 3 phosphorylation or the expression level of E-cadherin, N-cadherin or Snail, indicating that polyI:C suppressed cell motility independently of the "cadherin switching".	Poly I-C	342-349	phosphatase and tensin homolog	Homo sapiens	129-161
34390443-6	2021	By Western blotting, polyI:C dramatically decreased TGF-beta1-induced Ak strain transforming (Akt) phosphorylation and increased phosphatase and tensin homologue (PTEN) expression without affecting the Son of mothers against decapentaplegic (Smad) 3 phosphorylation or the expression level of E-cadherin, N-cadherin or Snail, indicating that polyI:C suppressed cell motility independently of the "cadherin switching".	Poly I-C	342-349	phosphatase and tensin homolog	Homo sapiens	163-167
34390443-7	2021	The Akt inhibitor perifosine inhibited TGF-beta1-induced cell invasion, and the PTEN-specific inhibitor VO-OHpic appeared to reverse the inhibitory effect of polyI:C.	Poly I-C	158-165	transforming growth factor beta 1	Homo sapiens	39-48
34390443-7	2021	The Akt inhibitor perifosine inhibited TGF-beta1-induced cell invasion, and the PTEN-specific inhibitor VO-OHpic appeared to reverse the inhibitory effect of polyI:C.	Poly I-C	158-165	phosphatase and tensin homolog	Homo sapiens	80-84
34390443-8	2021	CONCLUSION: PolyI:C has a novel function to suppress the motility of LC cells undergoing EMT by targeting the phosphatidylinositol 3-kinase/Akt pathway partly via PTEN and may prevent or reduce the metastasis of LC cells.	Poly I-C	12-19	phosphatase and tensin homolog	Homo sapiens	163-167
34391473-9	2021	In addition, an up-regulation of TGF-beta, IL-33 and IFN-beta was recorded after exposure to lipofected Poly I:C that also affected the monolayer integrity.	Poly I-C	104-112	transforming growth factor alpha	Equus caballus	33-41
34497658-10	2021	LBO could also effectively downregulate the expression of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interferon-beta and the activation of P65 and IRF3 in Poly I:C-treated cells.	Poly I-C	168-176	interleukin 6	Mus musculus	103-107
34497658-10	2021	LBO could also effectively downregulate the expression of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interferon-beta and the activation of P65 and IRF3 in Poly I:C-treated cells.	Poly I-C	168-176	RELA proto-oncogene, NF-kB subunit	Homo sapiens	152-155
34497658-10	2021	LBO could also effectively downregulate the expression of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interferon-beta and the activation of P65 and IRF3 in Poly I:C-treated cells.	Poly I-C	168-176	interferon regulatory factor 3	Mus musculus	160-164
34256323-11	2021	DISCUSSION: Poly(I:C)-mediated MIA activates AMPK and inhibits mTORC1 in rat placenta, both of which decrease expression and membrane localization of EAAT2 and ASCT1 in vitro.	Poly I-C	12-21	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	45-49
34256323-11	2021	DISCUSSION: Poly(I:C)-mediated MIA activates AMPK and inhibits mTORC1 in rat placenta, both of which decrease expression and membrane localization of EAAT2 and ASCT1 in vitro.	Poly I-C	12-21	CREB regulated transcription coactivator 1	Mus musculus	63-69
34256323-11	2021	DISCUSSION: Poly(I:C)-mediated MIA activates AMPK and inhibits mTORC1 in rat placenta, both of which decrease expression and membrane localization of EAAT2 and ASCT1 in vitro.	Poly I-C	12-21	solute carrier family 1 member 2	Rattus norvegicus	150-155
34256323-11	2021	DISCUSSION: Poly(I:C)-mediated MIA activates AMPK and inhibits mTORC1 in rat placenta, both of which decrease expression and membrane localization of EAAT2 and ASCT1 in vitro.	Poly I-C	12-21	solute carrier family 1 member 4	Rattus norvegicus	160-165
34161582-10	2021	RNase T2 in bone marrow-derived macrophages was broadly distributed from early endosomes to lysosomes, and colocalized with the internalized TLR3 ligand poly(I:C).	Poly I-C	153-162	ribonuclease T2A	Mus musculus	0-8
34161582-10	2021	RNase T2 in bone marrow-derived macrophages was broadly distributed from early endosomes to lysosomes, and colocalized with the internalized TLR3 ligand poly(I:C).	Poly I-C	153-162	toll-like receptor 3	Mus musculus	141-145
34428519-8	2022	Poly (I:C) promoted production of interferon (IFN)-alpha, -beta, and -gamma, and its inhibitory effects were dependent on the IFN-alpha/beta receptor pathway.	Poly I-C	0-10	interferon alpha	Mus musculus	34-75
34391473-9	2021	In addition, an up-regulation of TGF-beta, IL-33 and IFN-beta was recorded after exposure to lipofected Poly I:C that also affected the monolayer integrity.	Poly I-C	104-112	interleukin 33	Equus caballus	43-48
34391473-9	2021	In addition, an up-regulation of TGF-beta, IL-33 and IFN-beta was recorded after exposure to lipofected Poly I:C that also affected the monolayer integrity.	Poly I-C	104-112	interferon beta	Equus caballus	53-61
34381879-8	2021	The IFN-beta-dependent expression of RIG-I and upregulation of IFN-beta in the poly(I:C) stimulation demonstrated a positive-feedback loop via RIG-I, usually evident in ducks.	Poly I-C	79-88	interferon	Gallus gallus	4-12
34376208-8	2021	CatH processing in microglia was assayed by pulse-chase experiments, while immunoblotting was used to examine TLR3 expression and IRF3 activation in microglia/macrophages in the presence of poly(I:C).	Poly I-C	190-199	toll-like receptor 3	Mus musculus	110-114
34098313-7	2021	Further, poly(I:C) or dsRNA virus elevated the levels of myeloperoxidase-DNA complexes and citrullinated histone H3, which are specific markers of NETs, in both neutrophil supernatants and mouse plasma.	Poly I-C	9-18	myeloperoxidase	Mus musculus	57-72
34098313-8	2021	Interestingly, a potent peptidylarginine deiminase 4 (PAD4) inhibitor, BB-CL-Amidine (BB-CLA) or PAD4 knockdown effectively prevented poly(I:C)-induced NETs formation and release.	Poly I-C	134-143	peptidyl arginine deiminase 4	Homo sapiens	24-52
34098313-8	2021	Interestingly, a potent peptidylarginine deiminase 4 (PAD4) inhibitor, BB-CL-Amidine (BB-CLA) or PAD4 knockdown effectively prevented poly(I:C)-induced NETs formation and release.	Poly I-C	134-143	peptidyl arginine deiminase 4	Homo sapiens	54-58
34098313-8	2021	Interestingly, a potent peptidylarginine deiminase 4 (PAD4) inhibitor, BB-CL-Amidine (BB-CLA) or PAD4 knockdown effectively prevented poly(I:C)-induced NETs formation and release.	Poly I-C	134-143	peptidyl arginine deiminase 4	Homo sapiens	97-101
34098313-11	2021	Taken together, these results suggest that viral mimetic poly(I:C) may induce NETs-dependent inflammation and thrombosis through PAD4, and that inhibiting PAD4 may become a good strategy to protect against viral infection-caused inflammation/thrombosis-related pathological conditions of diseases.	Poly I-C	57-66	peptidyl arginine deiminase 4	Homo sapiens	129-133
34098313-11	2021	Taken together, these results suggest that viral mimetic poly(I:C) may induce NETs-dependent inflammation and thrombosis through PAD4, and that inhibiting PAD4 may become a good strategy to protect against viral infection-caused inflammation/thrombosis-related pathological conditions of diseases.	Poly I-C	57-66	peptidyl arginine deiminase 4	Homo sapiens	155-159
34440683-5	2021	Following induction of APOL1 expression by polyinosinic-polycytidylic acid (poly(I:C)), we assessed functional features of APOL1-induced podocyte dysfunction.	Poly I-C	43-74	apolipoprotein L1	Homo sapiens	23-28
34144136-2	2021	The immunostimulatory polyanions polyI:C and CpG induce potent pro-inflammatory immune responses as TLR3 and TLR9 agonists, respectively.	Poly I-C	33-40	toll like receptor 3	Homo sapiens	100-104
34144136-2	2021	The immunostimulatory polyanions polyI:C and CpG induce potent pro-inflammatory immune responses as TLR3 and TLR9 agonists, respectively.	Poly I-C	33-40	toll like receptor 9	Homo sapiens	109-113
34409402-5	2021	In these fetuses, significant increases were observed in the proportion of Pax6-positive neural progenitor cells and Pax6/Tbr2 double-positive cells 24 h after poly(I:C) injection.	Poly I-C	160-169	paired box 6	Mus musculus	75-79
34409402-5	2021	In these fetuses, significant increases were observed in the proportion of Pax6-positive neural progenitor cells and Pax6/Tbr2 double-positive cells 24 h after poly(I:C) injection.	Poly I-C	160-169	paired box 6	Mus musculus	117-121
34409402-5	2021	In these fetuses, significant increases were observed in the proportion of Pax6-positive neural progenitor cells and Pax6/Tbr2 double-positive cells 24 h after poly(I:C) injection.	Poly I-C	160-169	eomesodermin	Mus musculus	122-126
34409402-7	2021	At E18.5, there were more Pax6-positive and Tbr2-positive neural progenitor cells in the poly(I:C)-injected group than in the saline-injected group.	Poly I-C	89-98	paired box 6	Mus musculus	26-30
34409402-7	2021	At E18.5, there were more Pax6-positive and Tbr2-positive neural progenitor cells in the poly(I:C)-injected group than in the saline-injected group.	Poly I-C	89-98	eomesodermin	Mus musculus	44-48
34409402-10	2021	Our results show that poly(I:C)-induced MIA at E12.5 leads to dysregulated neurogenesis and upregulates Atf4 in the fetal brain.	Poly I-C	22-31	activating transcription factor 4	Mus musculus	104-108
34098343-0	2021	Poly (I: C) inhibits reticuloendothelial virus replication in chicken macrophage-like cells through the activation of toll-like receptor-3 signaling.	Poly I-C	0-11	toll like receptor 3	Gallus gallus	118-138
34098343-6	2021	Furthermore, Poly (I: C) treatment promoted interferon-beta secretion from HD11 post REV infection.	Poly I-C	13-24	interferon omega 1	Gallus gallus	44-59
34098343-8	2021	The above results suggested that Poly (I: C) treatment switches HD11 into M1-like polarization to secret more interferon-beta and activate TLR-3 signaling, which contributes to block REV replication.	Poly I-C	33-44	interferon omega 1	Gallus gallus	110-125
34098343-8	2021	The above results suggested that Poly (I: C) treatment switches HD11 into M1-like polarization to secret more interferon-beta and activate TLR-3 signaling, which contributes to block REV replication.	Poly I-C	33-44	toll like receptor 3	Gallus gallus	139-144
34381879-6	2021	The knocked-in DF-1 cells expressed RIG-I via the stimulation of IFN-beta and poly(I:C) in a dose-dependent manner.	Poly I-C	78-87	antiviral innate immune response receptor RIG-I	Anas platyrhynchos	36-41
34381879-7	2021	Moreover, poly(I:C) stimulation in the knocked-in DF-1 cells upregulated RIG-I-like receptor (RLR) family signaling pathway-related genes IFN-beta, OASL, and IRF7.	Poly I-C	10-19	interferon	Gallus gallus	138-146
34381879-7	2021	Moreover, poly(I:C) stimulation in the knocked-in DF-1 cells upregulated RIG-I-like receptor (RLR) family signaling pathway-related genes IFN-beta, OASL, and IRF7.	Poly I-C	10-19	2'-5'-oligoadenylate synthetase like	Gallus gallus	148-152
34381879-7	2021	Moreover, poly(I:C) stimulation in the knocked-in DF-1 cells upregulated RIG-I-like receptor (RLR) family signaling pathway-related genes IFN-beta, OASL, and IRF7.	Poly I-C	10-19	interferon regulatory factor 7	Gallus gallus	158-162
34381879-8	2021	The IFN-beta-dependent expression of RIG-I and upregulation of IFN-beta in the poly(I:C) stimulation demonstrated a positive-feedback loop via RIG-I, usually evident in ducks.	Poly I-C	79-88	antiviral innate immune response receptor RIG-I	Anas platyrhynchos	37-42
34381879-8	2021	The IFN-beta-dependent expression of RIG-I and upregulation of IFN-beta in the poly(I:C) stimulation demonstrated a positive-feedback loop via RIG-I, usually evident in ducks.	Poly I-C	79-88	interferon	Gallus gallus	63-71
34381879-8	2021	The IFN-beta-dependent expression of RIG-I and upregulation of IFN-beta in the poly(I:C) stimulation demonstrated a positive-feedback loop via RIG-I, usually evident in ducks.	Poly I-C	79-88	antiviral innate immune response receptor RIG-I	Anas platyrhynchos	143-148
34253819-6	2021	Interestingly, PAR1 enhanced poly I:C induction of CXCL10 in rat CFs but not in rat neonatal CMs.	Poly I-C	29-37	coagulation factor II (thrombin) receptor	Rattus norvegicus	15-19
34349759-2	2021	We hypothesized that systemic endotoxemia via the gut-lung axis would lead to non-canonical and canonical inflammasome activation and pyroptosis in a two-hit model involving polyinosinic-polycytidylic acid (Poly(I:C)), a synthetic analog of dsRNA and MTV and that this would associate with acute lung injury (ALI).	Poly I-C	174-205	glucuronidase, beta	Mus musculus	50-53
34349759-2	2021	We hypothesized that systemic endotoxemia via the gut-lung axis would lead to non-canonical and canonical inflammasome activation and pyroptosis in a two-hit model involving polyinosinic-polycytidylic acid (Poly(I:C)), a synthetic analog of dsRNA and MTV and that this would associate with acute lung injury (ALI).	Poly I-C	207-216	glucuronidase, beta	Mus musculus	50-53
34349759-9	2021	Poly(I:C)-MTV injury was sensitive to caspase-11 deletion with no further contribution of caspase-1 except for maturation and release of IL-18 (that itself was sensitive to deletion of NLRP3).	Poly I-C	0-9	interleukin 18	Mus musculus	137-142
34349759-9	2021	Poly(I:C)-MTV injury was sensitive to caspase-11 deletion with no further contribution of caspase-1 except for maturation and release of IL-18 (that itself was sensitive to deletion of NLRP3).	Poly I-C	0-9	NLR family, pyrin domain containing 3	Mus musculus	185-190
34349759-12	2021	Conclusions: The previously noted exacerbation of mild Poly(I:C)-induced ALI by otherwise non-injurious MTV is associated with an increase in gut permeability resulting in systemic endotoxemia.	Poly I-C	55-64	glucuronidase, beta	Mus musculus	142-145
34193600-0	2021	A Monocyte-Orchestrated IFN-I-to-IL-4 Cytokine Axis Instigates Protumoral Macrophages and Thwarts Poly(I:C) Therapy.	Poly I-C	98-107	interleukin 4	Mus musculus	33-37
34193600-3	2021	Indeed, our recent work showed that systemic poly(I:C)/IFN treatment can undesirably trigger high arginase (ARG1) expression within the tumor-associated monocyte/macrophage compartment.	Poly I-C	45-54	arginase, liver	Mus musculus	108-112
34193600-7	2021	Genetic abrogation of IL-4 signaling in mice diminished poly(I:C)/IFN-induced ARG1 in tumors, leading to enhanced activation of CD8+ T cells and an improved therapeutic effect.	Poly I-C	56-65	interleukin 4	Mus musculus	22-26
34193600-7	2021	Genetic abrogation of IL-4 signaling in mice diminished poly(I:C)/IFN-induced ARG1 in tumors, leading to enhanced activation of CD8+ T cells and an improved therapeutic effect.	Poly I-C	56-65	arginase, liver	Mus musculus	78-82
34242391-2	2021	We investigated how signaling by coagulation proteases affects the quality and extent of the response to the TLR3-ligand poly(I:C) in human endothelial cells.	Poly I-C	121-130	toll like receptor 3	Homo sapiens	109-113
34278782-4	2021	Here, we describe the synthesis of SNAs that incorporate both a TLR3 agonist (polyinosinic:polycytidylic acid, poly(I:C)) and TLR9 agonist (CpG oligonucleotide) on the same liposomal scaffold.	Poly I-C	111-120	toll-like receptor 3	Mus musculus	64-68
34253819-6	2021	Interestingly, PAR1 enhanced poly I:C induction of CXCL10 in rat CFs but not in rat neonatal CMs.	Poly I-C	29-37	C-X-C motif chemokine ligand 10	Rattus norvegicus	51-57
35568245-7	2022	The viral mimetic poly(I:C) strongly induced IFN-beta expression in camel kidney cells.	Poly I-C	18-27	IFN1@	Homo sapiens	45-53
34259355-9	2022	Renitence induced by the TLR3 agonist Poly(I:C) was mediated in part by the type I IFN response, but renitence induced by Pam3CSK4 (TLR2/1), LPS (TLR4), IFNgamma, or TNFalpha was independent of type 1 IFN signaling.	Poly I-C	38-47	toll-like receptor 3	Mus musculus	25-29
34253436-9	2022	RESULTS: Pg-LPS or poly I:C significantly enhanced the production of IL-6 and PGE2 in MG63 cells.	Poly I-C	19-27	interleukin 6	Homo sapiens	69-73
34414891-5	2021	The experimental results showed that ethanol and the TLR3 agonist Poly (I:C) increased the content of TLR3, IFNbeta, and IFNgamma mRNA in the prefrontal cortex.	Poly I-C	66-76	toll like receptor 3	Homo sapiens	53-57
34414891-5	2021	The experimental results showed that ethanol and the TLR3 agonist Poly (I:C) increased the content of TLR3, IFNbeta, and IFNgamma mRNA in the prefrontal cortex.	Poly I-C	66-76	toll like receptor 3	Homo sapiens	102-106
34414891-5	2021	The experimental results showed that ethanol and the TLR3 agonist Poly (I:C) increased the content of TLR3, IFNbeta, and IFNgamma mRNA in the prefrontal cortex.	Poly I-C	66-76	interferon beta 1	Rattus norvegicus	108-115
34414891-5	2021	The experimental results showed that ethanol and the TLR3 agonist Poly (I:C) increased the content of TLR3, IFNbeta, and IFNgamma mRNA in the prefrontal cortex.	Poly I-C	66-76	interferon gamma	Rattus norvegicus	121-129
34109180-0	2021	Priming With Toll-Like Receptor 3 Agonist Poly(I:C) Enhances Content of Innate Immune Defense Proteins but Not MicroRNAs in Human Mesenchymal Stem Cell-Derived Extracellular Vesicles.	Poly I-C	42-51	toll like receptor 3	Homo sapiens	13-33
34068522-4	2021	Stimulation of T cell responses with the poly (I:C)-potentiated vaccination was confirmed by examining levels of CD3+ T cells, CD4-1+ T cells and CD4-2+ T cells.	Poly I-C	41-51	CD4 molecule	Homo sapiens	127-130
34068522-4	2021	Stimulation of T cell responses with the poly (I:C)-potentiated vaccination was confirmed by examining levels of CD3+ T cells, CD4-1+ T cells and CD4-2+ T cells.	Poly I-C	41-51	CD4 molecule	Homo sapiens	146-149
34068522-5	2021	Higher levels of CD4-2+ T cells were found in vaccinated fish than CD4-1+ T cells, believed to result from a synergistic effect between poly (I:C) administration and pathogenic VHSV immunization.	Poly I-C	136-146	CD4 molecule	Homo sapiens	17-20
34068522-5	2021	Higher levels of CD4-2+ T cells were found in vaccinated fish than CD4-1+ T cells, believed to result from a synergistic effect between poly (I:C) administration and pathogenic VHSV immunization.	Poly I-C	136-146	CD4 molecule	Homo sapiens	67-70
34068522-7	2021	The results of this study suggest that the outstanding protection obtained with the poly (I:C)-potentiated vaccination is due to the robust immune response initiated by the CD4-2+ T cells.	Poly I-C	84-94	CD4 molecule	Homo sapiens	173-176
34589729-6	2021	Meta-analysis showed increased IL-6 concentrations in the offspring of poly(I:C) exposed mothers.	Poly I-C	71-80	interleukin 6	Homo sapiens	31-35
34589729-8	2021	Furthermore, poly(I:C) administration during mid-gestation was associated with higher IL-6 concentrations in the offspring.	Poly I-C	13-22	interleukin 6	Homo sapiens	86-90
34589729-9	2021	Maternal poly(I:C) induced changes in IL-1beta, Il-10 and TNF-alpha concentrations were small and could not be associated with age of offspring, gestational period or sampling location.	Poly I-C	9-18	interleukin 1 alpha	Homo sapiens	38-46
34589729-9	2021	Maternal poly(I:C) induced changes in IL-1beta, Il-10 and TNF-alpha concentrations were small and could not be associated with age of offspring, gestational period or sampling location.	Poly I-C	9-18	interleukin 10	Homo sapiens	48-53
34589729-9	2021	Maternal poly(I:C) induced changes in IL-1beta, Il-10 and TNF-alpha concentrations were small and could not be associated with age of offspring, gestational period or sampling location.	Poly I-C	9-18	tumor necrosis factor	Homo sapiens	58-67
34358160-6	2021	Further, poly (I:C) significantly increased the frequency of IFN-gamma-expressing cells compared with control, whereas no significant difference was observed between the adjuvanted groups.	Poly I-C	9-19	interferon gamma	Homo sapiens	61-70
34177915-7	2021	Pre-exposure of cDC2 or CD14+ DCs to the live virus resulted in an increased production of IFN-alpha upon poly I:C stimulation, while pre-exposure to UV-inactivated virus tended to enhance the release of IL-10 upon gardiquimod stimulation.	Poly I-C	106-114	cyclin dependent kinase 1	Homo sapiens	16-20
34177915-7	2021	Pre-exposure of cDC2 or CD14+ DCs to the live virus resulted in an increased production of IFN-alpha upon poly I:C stimulation, while pre-exposure to UV-inactivated virus tended to enhance the release of IL-10 upon gardiquimod stimulation.	Poly I-C	106-114	CD14 molecule	Homo sapiens	24-28
34177915-7	2021	Pre-exposure of cDC2 or CD14+ DCs to the live virus resulted in an increased production of IFN-alpha upon poly I:C stimulation, while pre-exposure to UV-inactivated virus tended to enhance the release of IL-10 upon gardiquimod stimulation.	Poly I-C	106-114	interferon alpha 1	Homo sapiens	91-100
34144609-10	2021	Treatment of RPE cells with Pam3CSK4, LPS, PGN-SA, and Poly(I:C) enhanced lysozyme expression.	Poly I-C	55-64	lysozyme	Homo sapiens	74-82
34144609-11	2021	CRISPR/Cas9 deletion of lysozyme impaired bactericidal activity of ARPE19 cells and reduced their response to LPS and Poly(I:C) stimulation.	Poly I-C	118-127	lysozyme	Homo sapiens	24-32
34094036-7	2021	Nanos2 overexpressing MEF cells have shown restrictive inflammatory effects when cells were treated with inflammatory stimuli such as LPS and Poly (I:C).	Poly I-C	142-152	nanos C2HC-type zinc finger 2	Homo sapiens	0-6
35417747-7	2022	IP injection of poly I:C and R848 significantly increased iNOS mRNA expression in several organs including the liver.	Poly I-C	16-24	nitric oxide synthase 2	Gallus gallus	58-62
35417747-8	2022	On the other hand, poly I:C and R848 significantly decreased mRNA expressions of endothelial NOS and neural NOS in several organs, indicating that induction of iNOS might be responsible for increased NOx levels in plasma.	Poly I-C	19-27	nitric oxide synthase 2	Gallus gallus	160-164
35625659-7	2022	Prenatal Poly I:C exposure led to increased expression of AKT2 and GSK3beta.	Poly I-C	9-17	AKT serine/threonine kinase 2	Rattus norvegicus	58-62
35577001-5	2022	We found that R848 followed by Poly(I:C) acted as the most effective adjuvants to increase the percentage and number of IFN-gamma-producing effector NK cells in the lymph nodes of immunized mice.	Poly I-C	31-40	interferon gamma	Mus musculus	120-129
35609110-4	2022	In contrast, injection of the TLR3 agonist and double-stranded RNA mimic polyinosinic-polycytidylic acid, or poly(I:C), impacted growth in utero leading to reduced fetal size.	Poly I-C	73-104	toll-like receptor 3	Mus musculus	30-34
35609110-4	2022	In contrast, injection of the TLR3 agonist and double-stranded RNA mimic polyinosinic-polycytidylic acid, or poly(I:C), impacted growth in utero leading to reduced fetal size.	Poly I-C	109-118	toll-like receptor 3	Mus musculus	30-34
34977960-7	2022	Furthermore, pretreatment with ANA-12 (TrkB antagonist: twice weekly for 4 weeks) significantly blocked the beneficial effects of (R)-ketamine on cognitive deficits of adult offspring after prenatal poly(I:C) exposure.	Poly I-C	199-208	neurotrophic receptor tyrosine kinase 2	Homo sapiens	39-43
35298837-6	2022	In vitro studies showed that the mRNA expression of TNFSF10 was significantly stimulated by LPS in head kidney leucocytes, but remarkably inhibited by Poly I:C in spleen leucocytes.	Poly I-C	151-159	TNF superfamily member 10	Homo sapiens	52-59
35625659-7	2022	Prenatal Poly I:C exposure led to increased expression of AKT2 and GSK3beta.	Poly I-C	9-17	glycogen synthase kinase 3 alpha	Rattus norvegicus	67-75
35625659-9	2022	This study suggests that Poly I:C-elicited maternal immune activation and risperidone differentially modulate GABAergic neurotransmission and AKT-GSK3beta signaling in the VTA of adolescent rats.	Poly I-C	25-33	AKT serine/threonine kinase 1	Rattus norvegicus	142-145
35625659-9	2022	This study suggests that Poly I:C-elicited maternal immune activation and risperidone differentially modulate GABAergic neurotransmission and AKT-GSK3beta signaling in the VTA of adolescent rats.	Poly I-C	25-33	glycogen synthase kinase 3 alpha	Rattus norvegicus	146-154
35594991-7	2022	In particular, there was dramatically lower expression of dsRNA sensors including DDX58 (RIG-I) and OAS proteins, which resulted in attenuated functional responses when the oncogenic cells were treated with the dsRNA mimetic, polyI:C, and increased susceptibility to infection with an RNA virus.	Poly I-C	226-233	DExD/H-box helicase 58	Homo sapiens	82-87
35594991-7	2022	In particular, there was dramatically lower expression of dsRNA sensors including DDX58 (RIG-I) and OAS proteins, which resulted in attenuated functional responses when the oncogenic cells were treated with the dsRNA mimetic, polyI:C, and increased susceptibility to infection with an RNA virus.	Poly I-C	226-233	DExD/H-box helicase 58	Homo sapiens	89-94
35534784-8	2022	Pharmacological inhibition showed that Poly(I:C)-induced IL-1alpha secretion was mediated through endoplasmic reticulum (ER) stress and RIPK1 signalling pathway.	Poly I-C	39-48	interleukin 1 alpha	Homo sapiens	57-66
35546774-11	2022	Importantly, MDA5 silencing reversed the effects of ARL5B knockdown on mitochondrial-mediated apoptosis and glycolysis, whereas poly(I:C), as a ligand for MDA5, further enhanced ARL5B knockdown-facilitated mitochondrial apoptosis and the inhibition of glycolysis.	Poly I-C	128-137	interferon induced with helicase C domain 1	Homo sapiens	155-159
35546774-11	2022	Importantly, MDA5 silencing reversed the effects of ARL5B knockdown on mitochondrial-mediated apoptosis and glycolysis, whereas poly(I:C), as a ligand for MDA5, further enhanced ARL5B knockdown-facilitated mitochondrial apoptosis and the inhibition of glycolysis.	Poly I-C	128-137	ADP ribosylation factor like GTPase 5B	Homo sapiens	178-183
35534784-8	2022	Pharmacological inhibition showed that Poly(I:C)-induced IL-1alpha secretion was mediated through endoplasmic reticulum (ER) stress and RIPK1 signalling pathway.	Poly I-C	39-48	receptor interacting serine/threonine kinase 1	Homo sapiens	136-141
35534784-10	2022	RIPK1-targeted CRC cell pools exhibited decreased cell viability upon Poly(I:C) stimulation, suggesting a potential role of RIPK1 in CRC cells survival.	Poly I-C	70-79	receptor interacting serine/threonine kinase 1	Homo sapiens	0-5
35534784-10	2022	RIPK1-targeted CRC cell pools exhibited decreased cell viability upon Poly(I:C) stimulation, suggesting a potential role of RIPK1 in CRC cells survival.	Poly I-C	70-79	receptor interacting serine/threonine kinase 1	Homo sapiens	124-129
35510663-11	2022	CONCLUSION: We showed that poly I:C is neuroprotective and acts via the TLR3/NF-kappaB/TNF-alpha pathway.	Poly I-C	27-35	toll like receptor 3	Homo sapiens	72-76
35533022-10	2022	CONCLUSIONS: We describe the use of anti-CD25 antibody to reduce regulatory T cells and poly I:C as a Toll-like receptor 3 stimulator to mimic viral infection in a pregnant NOD mouse, which can be used as a model of "pregnancy-related" T1D.	Poly I-C	88-96	toll-like receptor 3	Mus musculus	102-122
35510663-11	2022	CONCLUSION: We showed that poly I:C is neuroprotective and acts via the TLR3/NF-kappaB/TNF-alpha pathway.	Poly I-C	27-35	nuclear factor kappa B subunit 1	Homo sapiens	77-86
35510663-11	2022	CONCLUSION: We showed that poly I:C is neuroprotective and acts via the TLR3/NF-kappaB/TNF-alpha pathway.	Poly I-C	27-35	tumor necrosis factor	Homo sapiens	87-96
35395252-2	2022	In the present study we administered the TLR3 agonist poly(I:C) in male and female Long-Evans rats to determine whether TLR3 agonism can increase alcohol consumption on a daily 15% alcohol operant self-administration paradigm.	Poly I-C	54-63	toll-like receptor 3	Rattus norvegicus	41-45
35438806-1	2022	Polyinosinic-polycytidylic acid (poly(I:C)) is the agonist of Toll-like receptor 3 (TLR3), which participates in innate immune responses under the condition of myocardial ischemia/reperfusion injury (MIRI).	Poly I-C	0-31	toll-like receptor 3	Rattus norvegicus	62-82
35438806-1	2022	Polyinosinic-polycytidylic acid (poly(I:C)) is the agonist of Toll-like receptor 3 (TLR3), which participates in innate immune responses under the condition of myocardial ischemia/reperfusion injury (MIRI).	Poly I-C	0-31	toll-like receptor 3	Rattus norvegicus	84-88
35438806-1	2022	Polyinosinic-polycytidylic acid (poly(I:C)) is the agonist of Toll-like receptor 3 (TLR3), which participates in innate immune responses under the condition of myocardial ischemia/reperfusion injury (MIRI).	Poly I-C	33-42	toll-like receptor 3	Rattus norvegicus	62-82
35438806-1	2022	Polyinosinic-polycytidylic acid (poly(I:C)) is the agonist of Toll-like receptor 3 (TLR3), which participates in innate immune responses under the condition of myocardial ischemia/reperfusion injury (MIRI).	Poly I-C	33-42	toll-like receptor 3	Rattus norvegicus	84-88
35438806-2	2022	It has been shown that poly(I:C) exhibited cardioprotective activities through the PI3K/Akt pathway, which is the main signal transduction pathway during autophagy.	Poly I-C	23-32	AKT serine/threonine kinase 1	Rattus norvegicus	88-91
35438806-6	2022	Moreover, poly(I:C) significantly promoted cell survival by restoring autophagy flux and then regulating it to an adequate level Increased autophagy protein Beclin1 and LC3II together with p62 degradation after additional chloroquine.	Poly I-C	10-19	beclin 1	Rattus norvegicus	157-164
35438806-6	2022	Moreover, poly(I:C) significantly promoted cell survival by restoring autophagy flux and then regulating it to an adequate level Increased autophagy protein Beclin1 and LC3II together with p62 degradation after additional chloroquine.	Poly I-C	10-19	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	169-174
35438806-6	2022	Moreover, poly(I:C) significantly promoted cell survival by restoring autophagy flux and then regulating it to an adequate level Increased autophagy protein Beclin1 and LC3II together with p62 degradation after additional chloroquine.	Poly I-C	10-19	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	189-192
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	Poly I-C	17-26	AKT serine/threonine kinase 1	Rattus norvegicus	46-49
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	Poly I-C	17-26	mechanistic target of rapamycin kinase	Rattus norvegicus	50-54
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	Poly I-C	17-26	mechanistic target of rapamycin kinase	Rattus norvegicus	170-174
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	Poly I-C	17-26	AKT serine/threonine kinase 1	Rattus norvegicus	270-273
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	Poly I-C	17-26	mechanistic target of rapamycin kinase	Rattus norvegicus	274-278
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	Poly I-C	344-352	AKT serine/threonine kinase 1	Rattus norvegicus	46-49
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	Poly I-C	344-352	mechanistic target of rapamycin kinase	Rattus norvegicus	50-54
35438806-9	2022	In conclusion, poly(I:C) promotes cardiomyocyte survival from ischemia/reperfusion injury by regulating autophagy via the PI3K/Akt/mTOR pathway.	Poly I-C	15-24	AKT serine/threonine kinase 1	Rattus norvegicus	127-130
35438806-9	2022	In conclusion, poly(I:C) promotes cardiomyocyte survival from ischemia/reperfusion injury by regulating autophagy via the PI3K/Akt/mTOR pathway.	Poly I-C	15-24	mechanistic target of rapamycin kinase	Rattus norvegicus	131-135
35477539-6	2022	Treatment with the TLR3 agonist poly(I:C) elevated the HPS signalling and antigen processing phenotype across in vitro and in vivo models.	Poly I-C	32-41	toll like receptor 3	Homo sapiens	19-23
35447294-0	2022	Dental Pulp Cells Conditioning Through Poly(I:C) Activation of Toll-Like Receptor 3 (TLR3) for Amplification of Trophic Factors.	Poly I-C	39-48	toll like receptor 3	Homo sapiens	63-83
35563088-0	2022	Urolithin A Inactivation of TLR3/TRIF Signaling to Block the NF-kappaB/STAT1 Axis Reduces Inflammation and Enhances Antioxidant Defense in Poly(I:C)-Induced RAW264.7 Cells.	Poly I-C	139-148	toll-like receptor 3	Mus musculus	28-32
35563088-0	2022	Urolithin A Inactivation of TLR3/TRIF Signaling to Block the NF-kappaB/STAT1 Axis Reduces Inflammation and Enhances Antioxidant Defense in Poly(I:C)-Induced RAW264.7 Cells.	Poly I-C	139-148	toll-like receptor adaptor molecule 2	Mus musculus	33-37
35563088-0	2022	Urolithin A Inactivation of TLR3/TRIF Signaling to Block the NF-kappaB/STAT1 Axis Reduces Inflammation and Enhances Antioxidant Defense in Poly(I:C)-Induced RAW264.7 Cells.	Poly I-C	139-148	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	61-70
35563088-0	2022	Urolithin A Inactivation of TLR3/TRIF Signaling to Block the NF-kappaB/STAT1 Axis Reduces Inflammation and Enhances Antioxidant Defense in Poly(I:C)-Induced RAW264.7 Cells.	Poly I-C	139-148	signal transducer and activator of transcription 1	Mus musculus	71-76
35563088-9	2022	Urolithin A was applied to investigate the blockade of the TLR3 signaling pathway in poly(I:C)-induced RAW264.7 cells.	Poly I-C	85-94	toll-like receptor 3	Mus musculus	59-63
35563088-12	2022	Thus, our results suggest that urolithin A inhibits TLR3-activated inflammatory and oxidative-associated pathways in macrophages, and that this inhibition is induced by poly(I:C).	Poly I-C	169-178	toll-like receptor 3	Mus musculus	52-56
35447294-0	2022	Dental Pulp Cells Conditioning Through Poly(I:C) Activation of Toll-Like Receptor 3 (TLR3) for Amplification of Trophic Factors.	Poly I-C	39-48	toll like receptor 3	Homo sapiens	85-89
35447294-10	2022	CONCLUSIONS: In vitro DPC conditioning through poly(I:C) activation of TLR3 led to amplification of trophic factors involved in tissue repair.	Poly I-C	47-56	toll like receptor 3	Homo sapiens	71-75
35033573-7	2022	In CIK cell, CiPRMT6 expression was up-regulated upon stimulation with poly (I:C); while overexpression of PRMT6 suppressed the promoter activity of grass carp IFN1 and reduced the phosphorylation of IRF3; however, the amount of PRMT6 mutant (lack of methyltransferase domain) was increased in the cytoplasm.	Poly I-C	71-81	protein arginine methyltransferase 6	Homo sapiens	229-234
35319228-6	2022	Furthermore, our data show that MDA5 is required for GATA3 expression in host cells with poly(I:C) treatment, so are the adaptor protein TBK1 and transcription factor IRF7, suggesting that induction of GATA3 expression in IBDV-infected cells relies on MDA5-TBK1-IRF7 signaling pathway.	Poly I-C	89-98	interferon induced with helicase C domain 1	Homo sapiens	32-36
35319228-6	2022	Furthermore, our data show that MDA5 is required for GATA3 expression in host cells with poly(I:C) treatment, so are the adaptor protein TBK1 and transcription factor IRF7, suggesting that induction of GATA3 expression in IBDV-infected cells relies on MDA5-TBK1-IRF7 signaling pathway.	Poly I-C	89-98	GATA binding protein 3	Homo sapiens	53-58
35319228-6	2022	Furthermore, our data show that MDA5 is required for GATA3 expression in host cells with poly(I:C) treatment, so are the adaptor protein TBK1 and transcription factor IRF7, suggesting that induction of GATA3 expression in IBDV-infected cells relies on MDA5-TBK1-IRF7 signaling pathway.	Poly I-C	89-98	TANK binding kinase 1	Homo sapiens	137-141
35319228-6	2022	Furthermore, our data show that MDA5 is required for GATA3 expression in host cells with poly(I:C) treatment, so are the adaptor protein TBK1 and transcription factor IRF7, suggesting that induction of GATA3 expression in IBDV-infected cells relies on MDA5-TBK1-IRF7 signaling pathway.	Poly I-C	89-98	interferon regulatory factor 7	Homo sapiens	167-171
35319228-6	2022	Furthermore, our data show that MDA5 is required for GATA3 expression in host cells with poly(I:C) treatment, so are the adaptor protein TBK1 and transcription factor IRF7, suggesting that induction of GATA3 expression in IBDV-infected cells relies on MDA5-TBK1-IRF7 signaling pathway.	Poly I-C	89-98	GATA binding protein 3	Homo sapiens	202-207
35443313-10	2022	Conclusions: Poly I:C can activate TLR3/TRIF/NF-kappaB and TLR3/TRIF/IRF3 signaling pathway, promote the function of downstream signaling molecules, and then promote the maturation of DC, induce the immune responses of CD4+T cell, and promote the maturation and activation of B cells and the immune response of rHBsAg.	Poly I-C	13-21	toll like receptor 3	Homo sapiens	35-39
35443313-10	2022	Conclusions: Poly I:C can activate TLR3/TRIF/NF-kappaB and TLR3/TRIF/IRF3 signaling pathway, promote the function of downstream signaling molecules, and then promote the maturation of DC, induce the immune responses of CD4+T cell, and promote the maturation and activation of B cells and the immune response of rHBsAg.	Poly I-C	13-21	TIR domain containing adaptor molecule 1	Homo sapiens	40-44
35443313-10	2022	Conclusions: Poly I:C can activate TLR3/TRIF/NF-kappaB and TLR3/TRIF/IRF3 signaling pathway, promote the function of downstream signaling molecules, and then promote the maturation of DC, induce the immune responses of CD4+T cell, and promote the maturation and activation of B cells and the immune response of rHBsAg.	Poly I-C	13-21	nuclear factor kappa B subunit 1	Homo sapiens	45-54
35443313-10	2022	Conclusions: Poly I:C can activate TLR3/TRIF/NF-kappaB and TLR3/TRIF/IRF3 signaling pathway, promote the function of downstream signaling molecules, and then promote the maturation of DC, induce the immune responses of CD4+T cell, and promote the maturation and activation of B cells and the immune response of rHBsAg.	Poly I-C	13-21	toll like receptor 3	Homo sapiens	59-63
35443313-10	2022	Conclusions: Poly I:C can activate TLR3/TRIF/NF-kappaB and TLR3/TRIF/IRF3 signaling pathway, promote the function of downstream signaling molecules, and then promote the maturation of DC, induce the immune responses of CD4+T cell, and promote the maturation and activation of B cells and the immune response of rHBsAg.	Poly I-C	13-21	TIR domain containing adaptor molecule 1	Homo sapiens	64-68
35443313-10	2022	Conclusions: Poly I:C can activate TLR3/TRIF/NF-kappaB and TLR3/TRIF/IRF3 signaling pathway, promote the function of downstream signaling molecules, and then promote the maturation of DC, induce the immune responses of CD4+T cell, and promote the maturation and activation of B cells and the immune response of rHBsAg.	Poly I-C	13-21	interferon regulatory factor 3	Homo sapiens	69-73
35443313-10	2022	Conclusions: Poly I:C can activate TLR3/TRIF/NF-kappaB and TLR3/TRIF/IRF3 signaling pathway, promote the function of downstream signaling molecules, and then promote the maturation of DC, induce the immune responses of CD4+T cell, and promote the maturation and activation of B cells and the immune response of rHBsAg.	Poly I-C	13-21	decorin	Mus musculus	184-186
35456206-6	2022	TLR3 activation via poly(I:C) significantly reduced apoptotic markers in both pre- and postconditioning, the former yielding more favorable results through an additional suppression of TLR4 and its downstream signaling.	Poly I-C	20-29	toll like receptor 3	Homo sapiens	0-4
35456206-6	2022	TLR3 activation via poly(I:C) significantly reduced apoptotic markers in both pre- and postconditioning, the former yielding more favorable results through an additional suppression of TLR4 and its downstream signaling.	Poly I-C	20-29	toll like receptor 4	Homo sapiens	185-189
35221299-3	2022	In this study, we used Beas-2B human bronchial epithelial cells to investigate the effects of the TLR3 agonist polyinosinic:polycytidylic acid (Poly(I:C)) on airway cell migration and primary cilia (PC) formation.	Poly I-C	144-153	toll like receptor 3	Homo sapiens	98-102
35227882-16	2022	The expression of STUB1 was attenuated by poly(I:C) treatment and SVCV infection.	Poly I-C	42-51	STIP1 homology and U-box containing protein 1	Homo sapiens	18-23
35040013-7	2022	We tested dermal fibroblasts from a patient with EV71 encephalitis and a TLR3 mutation and other patients with known genetic defects of TLR3 or related genes, assessing the response of these cells to TLR3 agonist poly(I:C) stimulation and EV71 infection.	Poly I-C	213-222	toll like receptor 3	Homo sapiens	200-204
35066760-5	2022	Murine microglia BV2 cells and primary murine microglia were exposed to the TLR3 ligand polyinosinic-polycytidylic acid (poly(I:C)) and the TLR4 ligand lipopolysaccharide (LPS), individually and simultaneously.	Poly I-C	88-119	toll-like receptor 3	Mus musculus	76-80
35066760-5	2022	Murine microglia BV2 cells and primary murine microglia were exposed to the TLR3 ligand polyinosinic-polycytidylic acid (poly(I:C)) and the TLR4 ligand lipopolysaccharide (LPS), individually and simultaneously.	Poly I-C	121-130	toll-like receptor 3	Mus musculus	76-80
35066760-6	2022	TLR3 and TLR4 co-activation resulted in increased inflammatory responses compared to individual TLR activation, where poly(I:C) and LPS induced distinct patterns of proinflammatory factors together with different patterns of cathepsin X expression and activity.	Poly I-C	118-127	toll-like receptor 3	Mus musculus	0-4
35066760-6	2022	TLR3 and TLR4 co-activation resulted in increased inflammatory responses compared to individual TLR activation, where poly(I:C) and LPS induced distinct patterns of proinflammatory factors together with different patterns of cathepsin X expression and activity.	Poly I-C	118-127	toll-like receptor 4	Mus musculus	9-13
35066760-6	2022	TLR3 and TLR4 co-activation resulted in increased inflammatory responses compared to individual TLR activation, where poly(I:C) and LPS induced distinct patterns of proinflammatory factors together with different patterns of cathepsin X expression and activity.	Poly I-C	118-127	cathepsin Z	Mus musculus	225-236
35066760-8	2022	Inhibition of cathepsin X in BV2 cells by AMS36, cathepsin X inhibitor, significantly reduced the poly(I:C)- and LPS-induced production of proinflammatory cytokines as well as apoptosis.	Poly I-C	98-107	cathepsin Z	Mus musculus	14-25
35151092-5	2022	Importantly, the combination of poly(I:C) with proteasome inhibitors enhanced caspase-8 and caspase-9 activation, and synergistically induced cervical cancer cell apoptosis.	Poly I-C	32-41	caspase 8	Homo sapiens	78-87
35151092-5	2022	Importantly, the combination of poly(I:C) with proteasome inhibitors enhanced caspase-8 and caspase-9 activation, and synergistically induced cervical cancer cell apoptosis.	Poly I-C	32-41	caspase 9	Homo sapiens	92-101
35310053-1	2022	AIM: To study the role of luteolin (LUT) in the expression of toll-like receptors 3 (TLR3) ligand polyI:C stimulated inflammatory factors in human corneal fibroblasts (HCFs).	Poly I-C	98-105	toll like receptor 3	Homo sapiens	62-83
35310053-1	2022	AIM: To study the role of luteolin (LUT) in the expression of toll-like receptors 3 (TLR3) ligand polyI:C stimulated inflammatory factors in human corneal fibroblasts (HCFs).	Poly I-C	98-105	toll like receptor 3	Homo sapiens	85-89
35310053-6	2022	RESULTS: Corneal fibroblasts exposed to polyI:C demonstrated decreased VCAM-1, ICAM-1, MCP-1, IL-6, and IL-8 expression levels upon exposure to LUT in a time-dependent and concentration-dependent manner.	Poly I-C	40-47	vascular cell adhesion molecule 1	Homo sapiens	71-77
35310053-6	2022	RESULTS: Corneal fibroblasts exposed to polyI:C demonstrated decreased VCAM-1, ICAM-1, MCP-1, IL-6, and IL-8 expression levels upon exposure to LUT in a time-dependent and concentration-dependent manner.	Poly I-C	40-47	intercellular adhesion molecule 1	Homo sapiens	79-85
35310053-6	2022	RESULTS: Corneal fibroblasts exposed to polyI:C demonstrated decreased VCAM-1, ICAM-1, MCP-1, IL-6, and IL-8 expression levels upon exposure to LUT in a time-dependent and concentration-dependent manner.	Poly I-C	40-47	interleukin 6	Homo sapiens	94-98
35310053-6	2022	RESULTS: Corneal fibroblasts exposed to polyI:C demonstrated decreased VCAM-1, ICAM-1, MCP-1, IL-6, and IL-8 expression levels upon exposure to LUT in a time-dependent and concentration-dependent manner.	Poly I-C	40-47	chemokine (C-X-C motif) ligand 15	Mus musculus	104-108
35335126-5	2022	We employed the use of poly(I:C) and lipopolysaccharide (LPS) to induce viral TLR3 and bacterial TLR4 signalling, and PBMCs were pre-exposed to plant-derived highly purified THC (10 muM), CBD (10 muM), or a combination of both phytocannabinoids (1:1 ratio, 10:10 muM), prior to LPS/poly(I:C) exposure.	Poly I-C	23-32	toll like receptor 3	Homo sapiens	78-82
35101442-6	2022	In osteoblasts, poly(I:C) increased PGE2 production and upregulated the mRNA expression of PGE2-related genes, Ptgs2 and Ptges, as well as that of a gene related to osteoclast differentiation, Tnfsf11.	Poly I-C	16-25	prostaglandin-endoperoxide synthase 2	Mus musculus	111-116
35101442-9	2022	In ex vivo organ cultures of periodontal alveolar bone, poly(I:C) induced bone-resorbing activity in a dose-dependent manner, which was attenuated by the simultaneous administration of either indomethacin or an EP4 antagonist.	Poly I-C	56-65	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	211-214
35101442-6	2022	In osteoblasts, poly(I:C) increased PGE2 production and upregulated the mRNA expression of PGE2-related genes, Ptgs2 and Ptges, as well as that of a gene related to osteoclast differentiation, Tnfsf11.	Poly I-C	16-25	prostaglandin E synthase	Mus musculus	121-126
35101442-6	2022	In osteoblasts, poly(I:C) increased PGE2 production and upregulated the mRNA expression of PGE2-related genes, Ptgs2 and Ptges, as well as that of a gene related to osteoclast differentiation, Tnfsf11.	Poly I-C	16-25	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	193-200
35101442-7	2022	In addition, we found that indomethacin (a COX-2 inhibitor) or an antagonist of the PGE2 receptor EP4 attenuated the poly(I:C)-induced PGE2 production and subsequent Tnfsf11 expression.	Poly I-C	117-126	cytochrome c oxidase II, mitochondrial	Mus musculus	43-48
35101442-7	2022	In addition, we found that indomethacin (a COX-2 inhibitor) or an antagonist of the PGE2 receptor EP4 attenuated the poly(I:C)-induced PGE2 production and subsequent Tnfsf11 expression.	Poly I-C	117-126	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	98-101
35101442-7	2022	In addition, we found that indomethacin (a COX-2 inhibitor) or an antagonist of the PGE2 receptor EP4 attenuated the poly(I:C)-induced PGE2 production and subsequent Tnfsf11 expression.	Poly I-C	117-126	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	166-173
34990938-7	2022	After challenge with Streptococcus agalactiae, lipopolysaccharides (LPS) and polyinosinic polycytidylic acid (Poly I:C), the expression level of Onddx43 mRNA was upregulated or downregulated in all of the tissues tested.	Poly I-C	77-108	probable ATP-dependent RNA helicase DDX43	Oreochromis niloticus	145-152
35065157-2	2022	A polyinosinic-polycytidylic acid (poly I:C) is a ligand for toll-like receptor 3 and a promising cancer adjuvant.	Poly I-C	2-33	toll like receptor 3	Homo sapiens	61-81
35065157-2	2022	A polyinosinic-polycytidylic acid (poly I:C) is a ligand for toll-like receptor 3 and a promising cancer adjuvant.	Poly I-C	35-43	toll like receptor 3	Homo sapiens	61-81
35114024-9	2022	RESULTS: Poly(I:C)-induced IFN-beta expression was reduced in HBECs from HDM+ compared to HDM- patients (p=0.05).	Poly I-C	9-18	IFN1@	Homo sapiens	27-35
35269457-3	2022	A major advance has been achieved with the discovery of the next generation maturation protocol involving TLR-3 agonist (poly I:C), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, interferon (IFN)-gamma, and IFN-alpha, and has since been known as alpha-type-1 maturation cocktail.	Poly I-C	121-129	toll like receptor 3	Homo sapiens	106-111
35103291-6	2022	The results demonstrated constitutive expression of ZAPL and ZAPS in RT7 and GT1 cells, and their expression in both cell types was notably increased by transfection of Poly(I:C) and Poly(dA:dT) when compared with no transfection.	Poly I-C	169-178	outer dense fiber of sperm tails 1	Homo sapiens	69-72
35269849-5	2022	Treatment of poly(I:C), a synthetic dsRNA analogue binding to toll-like receptor 3 (TLR3), generates ROS, which in turn activates TG2 in dermal fibroblast.	Poly I-C	13-22	toll-like receptor 3	Mus musculus	62-82
35269849-5	2022	Treatment of poly(I:C), a synthetic dsRNA analogue binding to toll-like receptor 3 (TLR3), generates ROS, which in turn activates TG2 in dermal fibroblast.	Poly I-C	13-22	toll-like receptor 3	Mus musculus	84-88
35269849-5	2022	Treatment of poly(I:C), a synthetic dsRNA analogue binding to toll-like receptor 3 (TLR3), generates ROS, which in turn activates TG2 in dermal fibroblast.	Poly I-C	13-22	transglutaminase 2, C polypeptide	Mus musculus	130-133
35269849-7	2022	We confirmed these results by assessing the level of MMP expression in Tlr3-/-, TG2-knockdowned and Tgm2-/- dermal fibroblasts after poly(I:C)-treatment.	Poly I-C	133-142	toll-like receptor 3	Mus musculus	71-75
35269849-7	2022	We confirmed these results by assessing the level of MMP expression in Tlr3-/-, TG2-knockdowned and Tgm2-/- dermal fibroblasts after poly(I:C)-treatment.	Poly I-C	133-142	transglutaminase 2, C polypeptide	Mus musculus	80-83
35269849-7	2022	We confirmed these results by assessing the level of MMP expression in Tlr3-/-, TG2-knockdowned and Tgm2-/- dermal fibroblasts after poly(I:C)-treatment.	Poly I-C	133-142	transglutaminase 2, C polypeptide	Mus musculus	100-104
35114024-12	2022	By contrast, Poly(I:C)-induced release of TSLP, a driver of T2 inflammation, was not reduced with exposure to HDM.	Poly I-C	13-22	thymic stromal lymphopoietin	Homo sapiens	42-46
35280398-1	2022	Background: Polyinosinic:polycytidylic acid (poly (I:C)) is a synthetic viral double-stranded RNA analog that can activate Toll-like receptor 3 (TLR3) and induce the release of thymic stromal lymphopoietin (TSLP).	Poly I-C	12-43	toll-like receptor 3	Mus musculus	123-143
35198771-5	2022	Poly(I:C), a toll-like receptor 3 agonist, was injected into mice every two days to simulate a systemic inflammatory state in which type I interferon (IFN-I) was produced.	Poly I-C	0-9	toll-like receptor 3	Mus musculus	13-33
35044632-7	2022	Reduction of cFLIPL protein levels by Usp27x-induction depended on TRIM28, which was also required for polyI:C-induced cell death.	Poly I-C	103-110	CASP8 and FADD like apoptosis regulator	Homo sapiens	13-19
35044632-7	2022	Reduction of cFLIPL protein levels by Usp27x-induction depended on TRIM28, which was also required for polyI:C-induced cell death.	Poly I-C	103-110	ubiquitin specific peptidase 27 X-linked	Homo sapiens	38-44
35044632-7	2022	Reduction of cFLIPL protein levels by Usp27x-induction depended on TRIM28, which was also required for polyI:C-induced cell death.	Poly I-C	103-110	tripartite motif containing 28	Homo sapiens	67-73
35280398-9	2022	In animals treated with poly (I:C), the levels of serum IL-4, IL-13 and TSLP increased significantly, while the level of IFN-gamma did not change.	Poly I-C	24-34	interleukin 4	Mus musculus	56-60
35280398-9	2022	In animals treated with poly (I:C), the levels of serum IL-4, IL-13 and TSLP increased significantly, while the level of IFN-gamma did not change.	Poly I-C	24-34	interleukin 13	Mus musculus	62-67
35280398-9	2022	In animals treated with poly (I:C), the levels of serum IL-4, IL-13 and TSLP increased significantly, while the level of IFN-gamma did not change.	Poly I-C	24-34	thymic stromal lymphopoietin	Mus musculus	72-76
35280398-1	2022	Background: Polyinosinic:polycytidylic acid (poly (I:C)) is a synthetic viral double-stranded RNA analog that can activate Toll-like receptor 3 (TLR3) and induce the release of thymic stromal lymphopoietin (TSLP).	Poly I-C	12-43	toll-like receptor 3	Mus musculus	145-149
35280398-1	2022	Background: Polyinosinic:polycytidylic acid (poly (I:C)) is a synthetic viral double-stranded RNA analog that can activate Toll-like receptor 3 (TLR3) and induce the release of thymic stromal lymphopoietin (TSLP).	Poly I-C	12-43	thymic stromal lymphopoietin	Mus musculus	177-205
35280398-1	2022	Background: Polyinosinic:polycytidylic acid (poly (I:C)) is a synthetic viral double-stranded RNA analog that can activate Toll-like receptor 3 (TLR3) and induce the release of thymic stromal lymphopoietin (TSLP).	Poly I-C	12-43	thymic stromal lymphopoietin	Mus musculus	207-211
35280398-1	2022	Background: Polyinosinic:polycytidylic acid (poly (I:C)) is a synthetic viral double-stranded RNA analog that can activate Toll-like receptor 3 (TLR3) and induce the release of thymic stromal lymphopoietin (TSLP).	Poly I-C	45-55	toll-like receptor 3	Mus musculus	123-143
35280398-9	2022	In animals treated with poly (I:C), the levels of serum IL-4, IL-13 and TSLP increased significantly, while the level of IFN-gamma did not change.	Poly I-C	24-34	interferon gamma	Mus musculus	121-130
35280398-1	2022	Background: Polyinosinic:polycytidylic acid (poly (I:C)) is a synthetic viral double-stranded RNA analog that can activate Toll-like receptor 3 (TLR3) and induce the release of thymic stromal lymphopoietin (TSLP).	Poly I-C	45-55	toll-like receptor 3	Mus musculus	145-149
35280398-11	2022	Conclusions: These data indicate that poly (I:C) treatment and exogenous activation of TLR3 exacerbate murine calcipotriol-induced AD-like skin lesions in part by increasing the production of TSLP and other T-helper 2 (Th2)-related cytokines.	Poly I-C	38-48	thymic stromal lymphopoietin	Mus musculus	192-196
35280398-1	2022	Background: Polyinosinic:polycytidylic acid (poly (I:C)) is a synthetic viral double-stranded RNA analog that can activate Toll-like receptor 3 (TLR3) and induce the release of thymic stromal lymphopoietin (TSLP).	Poly I-C	45-55	thymic stromal lymphopoietin	Mus musculus	177-205
35280398-1	2022	Background: Polyinosinic:polycytidylic acid (poly (I:C)) is a synthetic viral double-stranded RNA analog that can activate Toll-like receptor 3 (TLR3) and induce the release of thymic stromal lymphopoietin (TSLP).	Poly I-C	45-55	thymic stromal lymphopoietin	Mus musculus	207-211
2786554-2	1989	Two IFN inducers, polyinosinic-polycytidylic acid [poly(I)poly(C)] and polyadenylic-polyuridylic acid [poly(A)poly(U)], induced high IFN production in various tissues for a long time compared to treatment with murine interferon-beta.	Poly I-C	18-49	interferon beta 1, fibroblast	Mus musculus	217-232
35075101-5	2022	Moreover, NSP5 and N suppressed IFN expression induced by infection of Sendai virus or transfection of a synthetic mimic of dsRNA, poly (I:C), inhibiting TBK1 and IRF3 phosphorylation, and restraining the nuclear translocalization of IRF3.	Poly I-C	131-141	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	10-14
35215785-3	2022	In this study, we aimed at evaluating the therapeutic effect of a single intranasal treatment of the TLR3/MDA5 synthetic agonist Poly(I:C) against a lethal dose of SARS-CoV-2 in K18-hACE2 transgenic mice.	Poly I-C	129-138	toll like receptor 3	Homo sapiens	101-105
35215785-3	2022	In this study, we aimed at evaluating the therapeutic effect of a single intranasal treatment of the TLR3/MDA5 synthetic agonist Poly(I:C) against a lethal dose of SARS-CoV-2 in K18-hACE2 transgenic mice.	Poly I-C	129-138	interferon induced with helicase C domain 1	Homo sapiens	106-110
35215785-3	2022	In this study, we aimed at evaluating the therapeutic effect of a single intranasal treatment of the TLR3/MDA5 synthetic agonist Poly(I:C) against a lethal dose of SARS-CoV-2 in K18-hACE2 transgenic mice.	Poly I-C	129-138	keratin 18	Homo sapiens	178-181
35215785-3	2022	In this study, we aimed at evaluating the therapeutic effect of a single intranasal treatment of the TLR3/MDA5 synthetic agonist Poly(I:C) against a lethal dose of SARS-CoV-2 in K18-hACE2 transgenic mice.	Poly I-C	129-138	angiotensin converting enzyme 2	Homo sapiens	182-187
35174347-6	2022	In addition, the expression of pro-inflammatory genes stimulated by Poly(I:C) were reduced in DF-1 cells which overexpress PPDPF.	Poly I-C	68-77	pancreatic progenitor cell differentiation and proliferation factor	Gallus gallus	123-128
2533502-5	1989	Treatment of mice with Poly [I:C] alone [50 micrograms twice weekly, an inducer of Interferon (IFN) alpha/beta] or in conjunction with rIL-2 was even more effective, completely preventing glycosuria for 20 weeks.	Poly I-C	23-32	interferon alpha	Mus musculus	83-105
2480249-2	1989	The poly(rI) poly(rC)-induced inhibition of the enzymatic activity correlates with the observed increase of endogenous 2",5"-oligoadenylate cores which were reported to be potent inhibitors of ADPRP in vitro.	Poly I-C	4-21	poly (ADP-ribose) polymerase family, member 1	Mus musculus	193-198
2498428-5	1989	polyI:C, an inducer of IFN-alpha/beta, induced large increases in class I MHC in many tissues, with little effect on class II expression.	Poly I-C	0-7	interferon alpha	Mus musculus	23-32
2498428-8	1989	polyI:C increased renal class I MHC in nude mice and mice with severe combined immunodeficiency, and in mice treated with cyclosporine or mAb against IFN-gamma.	Poly I-C	0-7	interferon gamma	Mus musculus	150-159
2651135-10	1989	Poly I:C treatment caused an increase in both IL-1 and IL-2 production in control and Bu-pretreated mice and in the ability of the treated mice to reject transplanted lymphoma cells.	Poly I-C	0-8	interleukin 1 complex	Mus musculus	46-50
2651135-10	1989	Poly I:C treatment caused an increase in both IL-1 and IL-2 production in control and Bu-pretreated mice and in the ability of the treated mice to reject transplanted lymphoma cells.	Poly I-C	0-8	interleukin 2	Mus musculus	55-59
35098572-6	2022	CD80 and CD86 were consistently up-regulated in response to cytosolic Poly(I:C) stimulation in all cell types examined and CNA activation also induced robust Type I IFN and low levels of TNFalpha in monocytes, monocyte-derived macrophages, and monocyte-derived dendritic cells.	Poly I-C	70-79	CD80 molecule	Homo sapiens	0-4
35098572-6	2022	CD80 and CD86 were consistently up-regulated in response to cytosolic Poly(I:C) stimulation in all cell types examined and CNA activation also induced robust Type I IFN and low levels of TNFalpha in monocytes, monocyte-derived macrophages, and monocyte-derived dendritic cells.	Poly I-C	70-79	CD86 molecule	Homo sapiens	9-13
35098572-6	2022	CD80 and CD86 were consistently up-regulated in response to cytosolic Poly(I:C) stimulation in all cell types examined and CNA activation also induced robust Type I IFN and low levels of TNFalpha in monocytes, monocyte-derived macrophages, and monocyte-derived dendritic cells.	Poly I-C	70-79	tumor necrosis factor	Homo sapiens	187-195
35012562-4	2022	Inflammation was induced via the intranasal administration of polyinosinic-polycytidylic acid (poly(I:C), a TLR3 ligand) to the right nostril for 3 days.	Poly I-C	62-93	toll-like receptor 3	Mus musculus	108-112
35012562-4	2022	Inflammation was induced via the intranasal administration of polyinosinic-polycytidylic acid (poly(I:C), a TLR3 ligand) to the right nostril for 3 days.	Poly I-C	95-104	toll-like receptor 3	Mus musculus	108-112
34983106-5	2022	In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs.	Poly I-C	43-51	serum amyloid A1	Homo sapiens	99-103
34983106-5	2022	In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs.	Poly I-C	43-51	serum amyloid A1	Homo sapiens	159-163
34983106-5	2022	In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs.	Poly I-C	43-51	interleukin 6	Homo sapiens	195-213
34983106-5	2022	In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs.	Poly I-C	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
34983106-5	2022	In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs.	Poly I-C	43-51	S100 calcium binding protein A9	Homo sapiens	225-256
34983106-7	2022	In ovalbumin-induced asthma mice, Poly I-C treatment significantly increased SAA1 levels as well as IL-17A/interferon-gamma/IL-33 levels in bronchoalveolar lavage fluid (BALF), leading to airway hyperresponsiveness and inflammation.	Poly I-C	34-42	serum amyloid A 1	Mus musculus	77-81
34983106-7	2022	In ovalbumin-induced asthma mice, Poly I-C treatment significantly increased SAA1 levels as well as IL-17A/interferon-gamma/IL-33 levels in bronchoalveolar lavage fluid (BALF), leading to airway hyperresponsiveness and inflammation.	Poly I-C	34-42	interleukin 17A	Mus musculus	100-106
34983106-7	2022	In ovalbumin-induced asthma mice, Poly I-C treatment significantly increased SAA1 levels as well as IL-17A/interferon-gamma/IL-33 levels in bronchoalveolar lavage fluid (BALF), leading to airway hyperresponsiveness and inflammation.	Poly I-C	34-42	interferon gamma	Mus musculus	107-123
34983106-7	2022	In ovalbumin-induced asthma mice, Poly I-C treatment significantly increased SAA1 levels as well as IL-17A/interferon-gamma/IL-33 levels in bronchoalveolar lavage fluid (BALF), leading to airway hyperresponsiveness and inflammation.	Poly I-C	34-42	interleukin 33	Mus musculus	124-129
2731985-9	1989	Treatment with poly(I.C) significantly decreased the number of Mac3+ cells in the lungs, and these mice did not develop pulmonary hemorrhages.	Poly I-C	15-23	lysosomal-associated membrane protein 2	Mus musculus	63-67
2628585-10	1989	IFN-inducer, poly-IC, stimulated eNK-activity only in 6 of 26 ALL samples.	Poly I-C	13-20	interferon alpha 1	Homo sapiens	0-3
2628585-12	1989	Poly-IC induced significant IFN production only in one of six cultures of ALL.	Poly I-C	0-7	interferon alpha 1	Homo sapiens	28-31
2494047-2	1989	In contrast, pretreatment of murine L-929 cells with crystalline NiS inhibited severely IFN-alpha/beta induction by polyriboinosinic-polyribocytidylic acid, while amorphous NiS did not show any effect.	Poly I-C	116-155	interferon alpha	Mus musculus	88-97
2786554-2	1989	Two IFN inducers, polyinosinic-polycytidylic acid [poly(I)poly(C)] and polyadenylic-polyuridylic acid [poly(A)poly(U)], induced high IFN production in various tissues for a long time compared to treatment with murine interferon-beta.	Poly I-C	51-65	interferon beta 1, fibroblast	Mus musculus	217-232
2786554-4	1989	Poly(I)poly(C), however, brought about marked regression of the tumor when administered together with IL-2.	Poly I-C	0-14	interleukin 2	Mus musculus	102-106
2441862-4	1987	TIA was also inhibited by the potent IFN inducer polyriboinosinic-polyribocytidylic acid.	Poly I-C	49-88	interferon alpha 1	Homo sapiens	37-40
2603645-3	1989	PC from Balb/c nude mice treated with poly I:C also inhibited the take of SP4 tumour.	Poly I-C	38-46	trans-acting transcription factor 4	Mus musculus	74-77
3373554-11	1988	Although pretreatment with polyinosinic-polycytidylic acid enhanced in vitro NK cell activity, it could augment only slightly the clearance of YAC-1 cells from the lungs and the liver.	Poly I-C	27-58	ADP-ribosyltransferase 1	Mus musculus	143-148
2779948-1	1989	Murine L-929 cells were treated with benzene or a series of benzene metabolites, washed and then interferon-alpha/beta was induced with polyriboinosinic-polyribocytidylic acid.	Poly I-C	136-175	interferon alpha	Mus musculus	97-113
2826250-1	1987	Polyinosinic-polycytidylic acid, a potent inducer of inducer of interferon (IFN) production and activator of some IFN-induced enzymes, inhibits [3H]uridine incorporation into the RNA of vesicular stomatitis virus even in the absence of IFN synthesis, transiently triggers the breakdown of inositol phospholipids and activates the translocation of protein kinase C. Since IFNs also have similar activities these results suggest that IFN induction and IFN function are realised through common biochemical pathways.	Poly I-C	0-31	interferon alpha 1	Homo sapiens	76-79
2826250-1	1987	Polyinosinic-polycytidylic acid, a potent inducer of inducer of interferon (IFN) production and activator of some IFN-induced enzymes, inhibits [3H]uridine incorporation into the RNA of vesicular stomatitis virus even in the absence of IFN synthesis, transiently triggers the breakdown of inositol phospholipids and activates the translocation of protein kinase C. Since IFNs also have similar activities these results suggest that IFN induction and IFN function are realised through common biochemical pathways.	Poly I-C	0-31	interferon alpha 1	Homo sapiens	114-117
2826250-1	1987	Polyinosinic-polycytidylic acid, a potent inducer of inducer of interferon (IFN) production and activator of some IFN-induced enzymes, inhibits [3H]uridine incorporation into the RNA of vesicular stomatitis virus even in the absence of IFN synthesis, transiently triggers the breakdown of inositol phospholipids and activates the translocation of protein kinase C. Since IFNs also have similar activities these results suggest that IFN induction and IFN function are realised through common biochemical pathways.	Poly I-C	0-31	interferon alpha 1	Homo sapiens	114-117
2826250-1	1987	Polyinosinic-polycytidylic acid, a potent inducer of inducer of interferon (IFN) production and activator of some IFN-induced enzymes, inhibits [3H]uridine incorporation into the RNA of vesicular stomatitis virus even in the absence of IFN synthesis, transiently triggers the breakdown of inositol phospholipids and activates the translocation of protein kinase C. Since IFNs also have similar activities these results suggest that IFN induction and IFN function are realised through common biochemical pathways.	Poly I-C	0-31	interferon alpha 1	Homo sapiens	114-117
2826250-1	1987	Polyinosinic-polycytidylic acid, a potent inducer of inducer of interferon (IFN) production and activator of some IFN-induced enzymes, inhibits [3H]uridine incorporation into the RNA of vesicular stomatitis virus even in the absence of IFN synthesis, transiently triggers the breakdown of inositol phospholipids and activates the translocation of protein kinase C. Since IFNs also have similar activities these results suggest that IFN induction and IFN function are realised through common biochemical pathways.	Poly I-C	0-31	interferon alpha 1	Homo sapiens	114-117
3755596-1	1986	Polyriboinosinic-polyribocytidylic acid (poly IC), a potent interferon inducer, induced xanthine oxidase 24 hours after treatment with 5 mg/kg ip to different degrees among four H-2 congenic mice (P less than 0.05): B10 (H-2b: 236 +/- 27% of the control value) greater than B10.RIII (H-2r: 171 +/- 29%) = B10.F (H-2n: 161 +/- 12%) greater than B10.BR (H-2k: 136 +/- 15%).	Poly I-C	0-39	xanthine dehydrogenase	Mus musculus	88-104
3129897-5	1987	Transferring PC obtained after a single injection of poly I:C (100 micrograms intraperitoneally) resulted in retardation of growth of BaF1 fibrosarcoma and Sp4 adenocarcinoma or in a marked decrease in their take depending on the PC/tumour cell ratio.	Poly I-C	53-61	trans-acting transcription factor 4	Mus musculus	156-159
3447151-1	1987	Polyinosinic-polycytidylic acid [poly(I,C)] is a double-stranded RNA that is a potent interferon (IFN) inducer in rodents and, when suitably complexed with poly-L-lysine and carboxymethylcellulose [poly(I,C)-LC], also in primates and humans.	Poly I-C	0-31	interferon alpha 1	Homo sapiens	86-102
3447151-1	1987	Polyinosinic-polycytidylic acid [poly(I,C)] is a double-stranded RNA that is a potent interferon (IFN) inducer in rodents and, when suitably complexed with poly-L-lysine and carboxymethylcellulose [poly(I,C)-LC], also in primates and humans.	Poly I-C	33-42	interferon alpha 1	Homo sapiens	86-102
3447151-9	1987	It was of interest that coincubating poly(I,C)-LC and peritoneal macrophages in vitro resulted in the production of tumor necrosis factor, which has a similar pattern of toxicity; this finding suggests that poly(I,C)-LC"s pattern of toxicity may be associated with the induction of TNF and/or IFN.	Poly I-C	37-46	tumor necrosis factor	Mus musculus	282-285
2430524-10	1986	We conclude that poly(IC) decreases the content of proteins of the hepatic endoplasmic reticulum, including certain cytochrome P-450 isozymes, by decreasing rates of protein synthesis and increasing rates of protein degradation.	Poly I-C	17-25	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	116-132
2458787-5	1987	IFN production in response to stimulation with phytohemagglutinin or poly I:C was not detectable in most patients without GVHD until 7 months after grafting.	Poly I-C	69-77	interferon alpha 1	Homo sapiens	0-3
3612752-1	1987	We have defined the optimal circumstances for the induction of human interferon alpha (Hu IFN alpha) in peripheral blood mononuclear cells (PBMC) using complexed polyinosinic-polycytidylic acids (poly rIrC).	Poly I-C	162-194	interferon alpha 1	Homo sapiens	90-93
3612752-1	1987	We have defined the optimal circumstances for the induction of human interferon alpha (Hu IFN alpha) in peripheral blood mononuclear cells (PBMC) using complexed polyinosinic-polycytidylic acids (poly rIrC).	Poly I-C	196-205	interferon alpha 1	Homo sapiens	90-93
3447151-9	1987	It was of interest that coincubating poly(I,C)-LC and peritoneal macrophages in vitro resulted in the production of tumor necrosis factor, which has a similar pattern of toxicity; this finding suggests that poly(I,C)-LC"s pattern of toxicity may be associated with the induction of TNF and/or IFN.	Poly I-C	37-46	interferon alpha 1	Homo sapiens	293-296
3447151-9	1987	It was of interest that coincubating poly(I,C)-LC and peritoneal macrophages in vitro resulted in the production of tumor necrosis factor, which has a similar pattern of toxicity; this finding suggests that poly(I,C)-LC"s pattern of toxicity may be associated with the induction of TNF and/or IFN.	Poly I-C	37-45	tumor necrosis factor	Mus musculus	282-285
3447151-9	1987	It was of interest that coincubating poly(I,C)-LC and peritoneal macrophages in vitro resulted in the production of tumor necrosis factor, which has a similar pattern of toxicity; this finding suggests that poly(I,C)-LC"s pattern of toxicity may be associated with the induction of TNF and/or IFN.	Poly I-C	37-45	interferon alpha 1	Homo sapiens	293-296
3755596-1	1986	Polyriboinosinic-polyribocytidylic acid (poly IC), a potent interferon inducer, induced xanthine oxidase 24 hours after treatment with 5 mg/kg ip to different degrees among four H-2 congenic mice (P less than 0.05): B10 (H-2b: 236 +/- 27% of the control value) greater than B10.RIII (H-2r: 171 +/- 29%) = B10.F (H-2n: 161 +/- 12%) greater than B10.BR (H-2k: 136 +/- 15%).	Poly I-C	0-39	histocompatibility-2, MHC	Mus musculus	178-181
3755596-1	1986	Polyriboinosinic-polyribocytidylic acid (poly IC), a potent interferon inducer, induced xanthine oxidase 24 hours after treatment with 5 mg/kg ip to different degrees among four H-2 congenic mice (P less than 0.05): B10 (H-2b: 236 +/- 27% of the control value) greater than B10.RIII (H-2r: 171 +/- 29%) = B10.F (H-2n: 161 +/- 12%) greater than B10.BR (H-2k: 136 +/- 15%).	Poly I-C	0-39	granzyme C	Mus musculus	216-219
3755596-1	1986	Polyriboinosinic-polyribocytidylic acid (poly IC), a potent interferon inducer, induced xanthine oxidase 24 hours after treatment with 5 mg/kg ip to different degrees among four H-2 congenic mice (P less than 0.05): B10 (H-2b: 236 +/- 27% of the control value) greater than B10.RIII (H-2r: 171 +/- 29%) = B10.F (H-2n: 161 +/- 12%) greater than B10.BR (H-2k: 136 +/- 15%).	Poly I-C	0-39	granzyme C	Mus musculus	274-282
3755596-1	1986	Polyriboinosinic-polyribocytidylic acid (poly IC), a potent interferon inducer, induced xanthine oxidase 24 hours after treatment with 5 mg/kg ip to different degrees among four H-2 congenic mice (P less than 0.05): B10 (H-2b: 236 +/- 27% of the control value) greater than B10.RIII (H-2r: 171 +/- 29%) = B10.F (H-2n: 161 +/- 12%) greater than B10.BR (H-2k: 136 +/- 15%).	Poly I-C	0-39	granzyme C	Mus musculus	274-277
3755596-1	1986	Polyriboinosinic-polyribocytidylic acid (poly IC), a potent interferon inducer, induced xanthine oxidase 24 hours after treatment with 5 mg/kg ip to different degrees among four H-2 congenic mice (P less than 0.05): B10 (H-2b: 236 +/- 27% of the control value) greater than B10.RIII (H-2r: 171 +/- 29%) = B10.F (H-2n: 161 +/- 12%) greater than B10.BR (H-2k: 136 +/- 15%).	Poly I-C	0-39	granzyme C	Mus musculus	274-277
4006323-13	1985	Poly(I:C) treatment induced a shift of LGL and NK-1.2+ cells toward the low-density fractions.	Poly I-C	0-8	tachykinin receptor 1	Homo sapiens	47-51
2422400-6	1986	We show that these mice, carrying the BALB/c IFN-alpha structural genes on a C57BL/6 background, are high IFN producers when stimulated by Newcastle disease virus, Sendai virus, herpes simplex virus type 1, or polyriboinosinic-polyribocytidylic acid.	Poly I-C	210-249	interferon alpha	Mus musculus	45-54
2422427-0	1986	Kinetics of depression and recovery of murine hepatic cytochrome P-450 levels after treatment with the interferon inducer polyriboinosinic-polyribocytidylic acid.	Poly I-C	122-161	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	54-70
2422427-1	1986	In vivo treatment of randombred Swiss Webster mice with polyriboinosinic-polyribocytidylic acid (poly l X poly C) inhibited the induction of cytochrome P-450"s by both 3-methylcholanthrene [(MCA) CAS: 56-49-5] and phenobarbitol [(PB) CAS: 50-06-6].	Poly I-C	56-95	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	141-157
3519439-9	1986	Interestingly, FcR blockade by IgG-opsonized sheep erythrocyte conjugates selectively inhibited activation by MAF, LPS, and Poly I:C, but had no inhibitory effect on activation by CVF or zymosan.	Poly I-C	124-132	Fc receptor	Mus musculus	15-18
2418162-10	1985	Poly(I,C) complexes are effective IFN inducers in humans, but their toxicity limits their use in cancer patients.	Poly I-C	0-9	interferon alpha 1	Homo sapiens	34-37
4046739-10	1985	The inhibition of AHH by poly IC was much higher in old and middle-aged than in young mice, averaging 87.1%, 74.5%, and 41.9%, respectively, in the 3 age groups.	Poly I-C	25-32	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	18-21
3698007-6	1986	Interferon-alpha/beta was induced by addition of polyriboinosinic-polyribocytidylic acid to the cells.	Poly I-C	49-88	interferon alpha	Mus musculus	0-16
2934481-8	1986	In addition, incubation of LGL with b-end in the presence of phytohemagglutinin or poly I:C significantly augmented IFN production.	Poly I-C	83-91	interferon alpha 1	Homo sapiens	116-119
4087034-5	1985	In regard to cell surface markers, poly(I,C)-LC induced an increase in OKT10-positive cells and a small but consistent trend toward increases in the ratio of Leu-3/Leu-2-positive cells.	Poly I-C	35-44	CD8a molecule	Homo sapiens	164-169
4044058-8	1985	H-2- B16-L cells were more susceptible than H-2+ B16-S cells to in vitro lysis by poly I:C-treated splenocytes, and they acquired full metastatic abilities if the hosts were treated with anti-asialo GM-I serum.	Poly I-C	82-90	histocompatibility-2, MHC	Mus musculus	0-3
4044058-8	1985	H-2- B16-L cells were more susceptible than H-2+ B16-S cells to in vitro lysis by poly I:C-treated splenocytes, and they acquired full metastatic abilities if the hosts were treated with anti-asialo GM-I serum.	Poly I-C	82-90	histocompatibility-2, MHC	Mus musculus	44-47
2413749-1	1985	An optimal interferon (IFN) production was obtained at concentrations of 50 micrograms/ml poly I:C and 2000 micrograms/ml DEAE dextran in Lpa cells.	Poly I-C	90-98	interferon alpha 1	Homo sapiens	0-27
3996338-1	1985	The induction of interferon-alpha/beta (IFN-alpha/beta) by polyriboinosinic-polyribocytidylic acid (PIC) was inhibited when mouse embryo fibroblasts were pretreated with the carcinogen, benzo[a]pyrene (BP).	Poly I-C	59-98	interferon alpha B	Mus musculus	17-38
3996338-1	1985	The induction of interferon-alpha/beta (IFN-alpha/beta) by polyriboinosinic-polyribocytidylic acid (PIC) was inhibited when mouse embryo fibroblasts were pretreated with the carcinogen, benzo[a]pyrene (BP).	Poly I-C	59-98	interferon alpha	Mus musculus	40-49
3996338-1	1985	The induction of interferon-alpha/beta (IFN-alpha/beta) by polyriboinosinic-polyribocytidylic acid (PIC) was inhibited when mouse embryo fibroblasts were pretreated with the carcinogen, benzo[a]pyrene (BP).	Poly I-C	100-103	interferon alpha B	Mus musculus	17-38
3996338-1	1985	The induction of interferon-alpha/beta (IFN-alpha/beta) by polyriboinosinic-polyribocytidylic acid (PIC) was inhibited when mouse embryo fibroblasts were pretreated with the carcinogen, benzo[a]pyrene (BP).	Poly I-C	100-103	interferon alpha	Mus musculus	40-49
2984302-7	1985	The amount of IFN released by IM in response to poly I:C was approximately three times higher than the amount of IFN released by RM.	Poly I-C	48-56	interferon alpha 1	Homo sapiens	14-17
2984302-8	1985	IL-1 was also released in higher amounts by IM than by RM in response to poly I:C.	Poly I-C	73-81	interleukin 1 alpha	Homo sapiens	0-4
3919095-3	1985	Human peripheral blood adherent leukocytes incubated with interferon (IFN) of three different species (alpha, beta, or gamma) show an enhanced potential of IL 1 synthesis and secretion that can be revealed by a second signal provided by endotoxins or Poly IC.	Poly I-C	251-258	interferon alpha 1	Homo sapiens	58-74
3919095-3	1985	Human peripheral blood adherent leukocytes incubated with interferon (IFN) of three different species (alpha, beta, or gamma) show an enhanced potential of IL 1 synthesis and secretion that can be revealed by a second signal provided by endotoxins or Poly IC.	Poly I-C	251-258	interleukin 1 alpha	Homo sapiens	156-160
4000618-1	1985	L-929 cells were treated with benzo-(a)-pyrene (BP), washed, and then interferon(IFN)-alpha/beta was induced with polyriboinosinic-polyribocytidylic acid (poly-I-C).	Poly I-C	114-153	interferon alpha	Mus musculus	70-91
2578473-2	1985	The endothelial cells of the two species produced significant amounts of IFN in response to various viruses and poly (I) poly (C).	Poly I-C	112-129	interferon alpha 1	Homo sapiens	73-76
2578572-4	1985	IFN was implicated as mediating the effect of poly(I)-poly(C) because high systemic levels of IFN were evident after injection, and neither the magnitude of the inflammatory response nor the T-cell levels were affected when poly(I)-poly(C)-treated mice were also given anti-IFN antiserum.	Poly I-C	46-61	interferon alpha 1	Homo sapiens	0-3
2578572-4	1985	IFN was implicated as mediating the effect of poly(I)-poly(C) because high systemic levels of IFN were evident after injection, and neither the magnitude of the inflammatory response nor the T-cell levels were affected when poly(I)-poly(C)-treated mice were also given anti-IFN antiserum.	Poly I-C	46-61	interferon alpha 1	Homo sapiens	94-97
2578572-4	1985	IFN was implicated as mediating the effect of poly(I)-poly(C) because high systemic levels of IFN were evident after injection, and neither the magnitude of the inflammatory response nor the T-cell levels were affected when poly(I)-poly(C)-treated mice were also given anti-IFN antiserum.	Poly I-C	46-61	interferon alpha 1	Homo sapiens	94-97
4000618-1	1985	L-929 cells were treated with benzo-(a)-pyrene (BP), washed, and then interferon(IFN)-alpha/beta was induced with polyriboinosinic-polyribocytidylic acid (poly-I-C).	Poly I-C	155-163	interferon alpha	Mus musculus	70-91
6333472-4	1984	However, using Newcastle disease virus (NDV), measles virus, or poly I:C to stimulate IFN synthesis, cells from IFN-treated patients produced less IFN in response to all inducers, with titers ranging between 11% and 44% of pretherapy values.	Poly I-C	64-72	interferon alpha 1	Homo sapiens	86-89
6085673-5	1984	Poly I: C also induced IFN in some human lymphoblastoid cell lines in which IFN production is induced by Sendai virus.	Poly I-C	0-9	interferon alpha 1	Homo sapiens	23-26
6085673-5	1984	Poly I: C also induced IFN in some human lymphoblastoid cell lines in which IFN production is induced by Sendai virus.	Poly I-C	0-9	interferon alpha 1	Homo sapiens	76-79
6085673-6	1984	The antigenic types of IFN induced by poly I: C were the same as those induced by Sendai virus.	Poly I-C	38-47	interferon alpha 1	Homo sapiens	23-26
6084715-6	1984	In mice given PSK ip, poly I:C-treated spleen cells exerted slightly inhibiting effects on tumor growth.	Poly I-C	22-30	TAO kinase 2	Mus musculus	14-17
6088883-2	1984	Several cultures of cells were immediately treated with polyriboinosinic-polyribocytidylic acid (poly I:C) to induce interferon-alpha/beta (IFN).	Poly I-C	56-95	interferon alpha	Mus musculus	117-144
6088883-2	1984	Several cultures of cells were immediately treated with polyriboinosinic-polyribocytidylic acid (poly I:C) to induce interferon-alpha/beta (IFN).	Poly I-C	97-105	interferon alpha	Mus musculus	117-144
6483860-2	1984	After 1 and 2 weeks of suspension in an antiorthostatic (head-down tilt) position, the mice were challenged with polyriboinosinic-polyribocytidylic acid to induce interferon-alpha/beta.	Poly I-C	113-152	interferon alpha	Mus musculus	163-179
6333472-4	1984	However, using Newcastle disease virus (NDV), measles virus, or poly I:C to stimulate IFN synthesis, cells from IFN-treated patients produced less IFN in response to all inducers, with titers ranging between 11% and 44% of pretherapy values.	Poly I-C	64-72	interferon alpha 1	Homo sapiens	112-115
6333472-4	1984	However, using Newcastle disease virus (NDV), measles virus, or poly I:C to stimulate IFN synthesis, cells from IFN-treated patients produced less IFN in response to all inducers, with titers ranging between 11% and 44% of pretherapy values.	Poly I-C	64-72	interferon alpha 1	Homo sapiens	112-115
6192322-1	1983	The effects of double-stranded RNA (dsRNA) on interferon (IFN)-induced antiviral and anticellular activities was investigated by introducing poly(I)-poly(C) into mouse L-cells.	Poly I-C	141-156	interferon alpha 1	Homo sapiens	46-56
6201567-1	1984	Grivet monkeys immunosuppressed with either cyclophosphamide or methylprednisolone retain their capacity to produce interferon in response to poly I:C/poly-L-lysine (poly ICL).	Poly I-C	142-150	interferon alpha 1	Homo sapiens	116-126
6201569-4	1984	IFN-alpha/beta induction was then carried out using polyriboinosinic-polyribocytidylic acid.	Poly I-C	52-91	interferon alpha	Mus musculus	0-9
6322211-2	1984	Poly I:C reduced the microsomal concentration of cytochrome P-450 by 19% and decreased the maximal binding spectrum (delta Amax) resulting from addition of the type-II substrate 2,4-dichloro-6-phenylphenoxyethylamine to one fraction (B2) while increasing the affinity of that fraction for this substrate.	Poly I-C	0-8	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	49-65
6322211-4	1984	Since 14C-leucine incorporation into cytochrome P-450 was increased in poly I:C-treated rats, it is suggested that poly I:C depresses hepatic mixed-function oxidase activity by increasing the rate of degradation of specific cytochrome P-450s.	Poly I-C	71-79	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	37-53
6322211-4	1984	Since 14C-leucine incorporation into cytochrome P-450 was increased in poly I:C-treated rats, it is suggested that poly I:C depresses hepatic mixed-function oxidase activity by increasing the rate of degradation of specific cytochrome P-450s.	Poly I-C	71-79	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	224-240
6322211-4	1984	Since 14C-leucine incorporation into cytochrome P-450 was increased in poly I:C-treated rats, it is suggested that poly I:C depresses hepatic mixed-function oxidase activity by increasing the rate of degradation of specific cytochrome P-450s.	Poly I-C	115-123	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	37-53
6322211-4	1984	Since 14C-leucine incorporation into cytochrome P-450 was increased in poly I:C-treated rats, it is suggested that poly I:C depresses hepatic mixed-function oxidase activity by increasing the rate of degradation of specific cytochrome P-450s.	Poly I-C	115-123	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	224-240
6200554-1	1984	Interferon (IFN), types beta and gamma, and IFN inducers polyinosinic-polycytidylic acid and lymphocytic choriomeningitis virus all stimulated the generation of blast-NK cells in mouse spleens.	Poly I-C	57-88	interferon alpha 1	Homo sapiens	44-47
6201567-0	1984	Interferon response to poly IC/poly-L-lysine in normal and lymphocyte-suppressed primates.	Poly I-C	23-30	interferon alpha 1	Homo sapiens	0-10
6190759-8	1983	IFN inducers (polyinosinic acid-polycytidylic acid, 6-MFA [a mixture of proteins, polysaccharides, and double-stranded DNA isolated from Aspergillus ochraceus ATCC 28706]) protected a significant number of mice against SFV infection.	Poly I-C	14-50	interferon alpha 1	Homo sapiens	0-3
6192322-1	1983	The effects of double-stranded RNA (dsRNA) on interferon (IFN)-induced antiviral and anticellular activities was investigated by introducing poly(I)-poly(C) into mouse L-cells.	Poly I-C	141-156	interferon alpha 1	Homo sapiens	58-61
7057139-3	1982	The expression of gp70 in the serum was enhanced not only by LPS but also other inducers of acute phase reactants (APR) such as turpentine oil or polyriboinosinic-polyribocytidylic acid.	Poly I-C	146-185	embigin	Mus musculus	18-22
6180003-2	1982	The ability of SCID mononuclear cells to produce IFN-alpha in response to poly I:C but not to NDV may indicate a partial deficiency of IFN-alpha in SCID foals.	Poly I-C	74-82	interferon alpha 1	Homo sapiens	49-58
6180087-5	1981	Induced mutant cells synthesized IFN mRNA more quickly, and the IFN titers after induction with poly I:C were higher in mutant cell lines than those in the parent cell line.	Poly I-C	96-104	interferon alpha 1	Homo sapiens	33-36
6787132-8	1981	In addition, poly I:C induced strong tumoricidal activity in resident M phi and in peritoneal exudate cells from the genetically defective C3H/HeJ mice that normally do not respond to LPS and MAF treatment.	Poly I-C	13-21	avian musculoaponeurotic fibrosarcoma oncogene homolog	Mus musculus	192-195
6176485-2	1981	A comparative study of the production of IFN beta by human skin fibroblasts in monolayers was carried out using induction by NDV and poly I - poly C.	Poly I-C	133-148	interferon beta 1	Homo sapiens	41-49
6180087-5	1981	Induced mutant cells synthesized IFN mRNA more quickly, and the IFN titers after induction with poly I:C were higher in mutant cell lines than those in the parent cell line.	Poly I-C	96-104	interferon alpha 1	Homo sapiens	64-67
476634-4	1979	Of the immunomodulating agents, mycobacterial preparations (Bacillus Calmette-Guerin or interphase material), Corynebacterium parvum, and polyinosinic-polycytidylic acid moderately prolonged the survival time of mice bearing J774 or 70Z/2; the EL-4 lymphoma was refractory to all 10 immunomodulating agents.	Poly I-C	138-169	epilepsy 4	Mus musculus	244-248
192141-1	1977	Combined use of interferon inductor poly-IC and antibiotics (cycloheximide and actinomycin D) provided a significant increase (up to 1000 times) in interferon production by chick, mouse, monkey and human cells.	Poly I-C	36-43	interferon	Gallus gallus	16-26
192141-1	1977	Combined use of interferon inductor poly-IC and antibiotics (cycloheximide and actinomycin D) provided a significant increase (up to 1000 times) in interferon production by chick, mouse, monkey and human cells.	Poly I-C	36-43	interferon	Gallus gallus	148-158
33534941-7	2021	RESULTS: Poly(I:C) stimulated NHBE and BEAS-2B cells to produce CCL5.	Poly I-C	9-18	C-C motif chemokine ligand 5	Homo sapiens	64-68
4543458-4	1973	The similarity of the molecular structure of poly I.C to LPS, a material which also acts as a thymic-independent antigen and a B-cell mitogen, supports the hypothesis that the polyvalent nature of these materials accounts for their functional interaction with murine B cells.	Poly I-C	45-53	toll-like receptor 4	Mus musculus	57-60
5003738-0	1971	[Immunogenic capacity of poly I poly C methylated bovine serum albumin in rabbits, hamsters and mice].	Poly I-C	25-38	albumin	Oryctolagus cuniculus	57-70
1214797-4	1975	CD spectrum of poly (I+C) double complex is changed considerably upon addition of D-d: CD increases when P/N ratio is 10:1, decreases at P/N 1:1 and comes back to the initial spectrum at P/N 1:5.	Poly I-C	15-25	serpin family E member 2	Homo sapiens	187-194
4833920-0	1974	Protective effect of immunization with polyinosinic-polycytidylic acid complexed with methylated bovine serum albumin against Friend leukemia virus in mice.	Poly I-C	39-70	albumin	Mus musculus	104-117
33534941-8	2021	Poly(I:C) and IL-13 increased CCL5 production.	Poly I-C	0-9	C-C motif chemokine ligand 5	Homo sapiens	30-34
33534941-9	2021	Poly(I:C)-induced CCL5 production occurred via the TLR3-IRF3 and IFNAR/JAK1-phosphoinositide 3-kinase (PI3K) pathways, but not the IFNAR/JAK1-STATs pathway.	Poly I-C	0-9	C-C motif chemokine ligand 5	Homo sapiens	18-22
33534941-9	2021	Poly(I:C)-induced CCL5 production occurred via the TLR3-IRF3 and IFNAR/JAK1-phosphoinositide 3-kinase (PI3K) pathways, but not the IFNAR/JAK1-STATs pathway.	Poly I-C	0-9	toll like receptor 3	Homo sapiens	51-55
33534941-9	2021	Poly(I:C)-induced CCL5 production occurred via the TLR3-IRF3 and IFNAR/JAK1-phosphoinositide 3-kinase (PI3K) pathways, but not the IFNAR/JAK1-STATs pathway.	Poly I-C	0-9	interferon regulatory factor 3	Homo sapiens	56-60
33215508-11	2021	After stimulation with viral- or bacterial-mimics, including LPS, poly(I:C), pam3CSK4, FLS-1, FLA-ST and R848, the TLR3 transcript was significantly upregulated.	Poly I-C	66-75	toll like receptor 3	Homo sapiens	115-119
33534941-9	2021	Poly(I:C)-induced CCL5 production occurred via the TLR3-IRF3 and IFNAR/JAK1-phosphoinositide 3-kinase (PI3K) pathways, but not the IFNAR/JAK1-STATs pathway.	Poly I-C	0-9	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	65-101
33534941-9	2021	Poly(I:C)-induced CCL5 production occurred via the TLR3-IRF3 and IFNAR/JAK1-phosphoinositide 3-kinase (PI3K) pathways, but not the IFNAR/JAK1-STATs pathway.	Poly I-C	0-9	interferon alpha and beta receptor subunit 1	Homo sapiens	65-70
33534941-9	2021	Poly(I:C)-induced CCL5 production occurred via the TLR3-IRF3 and IFNAR/JAK1-phosphoinositide 3-kinase (PI3K) pathways, but not the IFNAR/JAK1-STATs pathway.	Poly I-C	0-9	Janus kinase 1	Homo sapiens	71-75
33534941-9	2021	Poly(I:C)-induced CCL5 production occurred via the TLR3-IRF3 and IFNAR/JAK1-phosphoinositide 3-kinase (PI3K) pathways, but not the IFNAR/JAK1-STATs pathway.	Poly I-C	0-9	signal transducer and activator of transcription 6	Homo sapiens	142-147
33830449-4	2021	The purified compounds, strictinin and casuarictin, inhibited the IL-8 mRNA expression and IL-8 release induced in NHEKs by poly(I:C).	Poly I-C	124-133	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
33830449-4	2021	The purified compounds, strictinin and casuarictin, inhibited the IL-8 mRNA expression and IL-8 release induced in NHEKs by poly(I:C).	Poly I-C	124-133	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
33830449-0	2021	Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production in human keratinocytes.	Poly I-C	44-53	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
33827951-9	2021	We further uncovered that knockout of FUS abolishes the ability to form SGs upon CVB3 infection or polyinosinic:polycytidylic acid (polyIC) treatment.	Poly I-C	132-138	FUS RNA binding protein	Homo sapiens	38-41
34050236-0	2021	Berberine modulates hyper-inflammation in mouse macrophages stimulated with polyinosinic-polycytidylic acid via calcium-CHOP/STAT pathway.	Poly I-C	76-107	DNA-damage inducible transcript 3	Mus musculus	120-124
34052233-10	2021	Furthermore, after knocking down of CgTRIM1, the mRNA expression levels of IFN-stimulated genes, including myxovirus resistance of oyster (CgMx) and Interferon-induced protein 44 (CgIFI44) were significantly down-regulated post poly (I:C) stimulation, while no significant change of the CgIFNLP expression was observed.	Poly I-C	228-238	interferon-induced protein 44	Crassostrea gigas	149-178
34030480-10	2021	Interestingly, HBV infection reduced IL-8 secretion induced by Poly(I:C)-HMW and to a lesser extent Poly(I:C)-HMW/LyoVec.	Poly I-C	63-72	cilia and flagella associated protein 97	Homo sapiens	73-76
34030480-9	2021	Moreover, Poly(I:C)-HMW/LyoVec and Poly(I:C)-HMW were the only ligands that significantly increased IL-8 secretion.	Poly I-C	10-19	cilia and flagella associated protein 97	Homo sapiens	20-23
34030480-10	2021	Interestingly, HBV infection reduced IL-8 secretion induced by Poly(I:C)-HMW and to a lesser extent Poly(I:C)-HMW/LyoVec.	Poly I-C	100-109	cilia and flagella associated protein 97	Homo sapiens	110-113
34030480-9	2021	Moreover, Poly(I:C)-HMW/LyoVec and Poly(I:C)-HMW were the only ligands that significantly increased IL-8 secretion.	Poly I-C	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
34030480-11	2021	Poly(I:C)-HMW/LyoVec had a significant effect on increasing the expression level of A3F, A3G, A3H, TLR3, RIG-1, and MDA5 genes.	Poly I-C	0-9	cilia and flagella associated protein 97	Homo sapiens	10-13
34030480-10	2021	Interestingly, HBV infection reduced IL-8 secretion induced by Poly(I:C)-HMW and to a lesser extent Poly(I:C)-HMW/LyoVec.	Poly I-C	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
34030480-11	2021	Poly(I:C)-HMW/LyoVec had a significant effect on increasing the expression level of A3F, A3G, A3H, TLR3, RIG-1, and MDA5 genes.	Poly I-C	0-9	toll like receptor 3	Homo sapiens	99-103
34030480-11	2021	Poly(I:C)-HMW/LyoVec had a significant effect on increasing the expression level of A3F, A3G, A3H, TLR3, RIG-1, and MDA5 genes.	Poly I-C	0-9	phospholipase A and acyltransferase 4	Homo sapiens	105-110
34030480-11	2021	Poly(I:C)-HMW/LyoVec had a significant effect on increasing the expression level of A3F, A3G, A3H, TLR3, RIG-1, and MDA5 genes.	Poly I-C	0-9	interferon induced with helicase C domain 1	Homo sapiens	116-120
34030480-13	2021	The RIG-1 and MDA5 agonist, Poly(I:C)-HMW/LyoVec, seems to downregulate HBV infection through induction of A3 genes.	Poly I-C	28-37	phospholipase A and acyltransferase 4	Homo sapiens	4-9
34030480-13	2021	The RIG-1 and MDA5 agonist, Poly(I:C)-HMW/LyoVec, seems to downregulate HBV infection through induction of A3 genes.	Poly I-C	28-37	interferon induced with helicase C domain 1	Homo sapiens	14-18
34030480-13	2021	The RIG-1 and MDA5 agonist, Poly(I:C)-HMW/LyoVec, seems to downregulate HBV infection through induction of A3 genes.	Poly I-C	28-37	cilia and flagella associated protein 97	Homo sapiens	38-41
33684425-4	2021	In Experiment 2, rats were neonatally treated with saline or the immune system stimulant polyinosinic:polycytidylic acid (Poly I:C) from P5-7.	Poly I-C	122-130	cyclin-dependent kinase inhibitor 1C	Rattus norvegicus	137-141
34009721-3	2021	Poly(I:C), a dsRNA surrogate, has been shown to induce inflammation, type I interferon (IFN) responses, and osteogenesis through Toll-like receptor 3 in aortic valve interstitial cells (VIC).	Poly I-C	0-9	toll like receptor 3	Homo sapiens	129-149
34028652-7	2021	Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001).	Poly I-C	34-44	intercellular adhesion molecule 1	Mus musculus	147-152
34028652-7	2021	Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001).	Poly I-C	34-44	toll-like receptor 3	Mus musculus	154-158
34028652-7	2021	Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001).	Poly I-C	34-44	interleukin 6	Mus musculus	160-163
34028652-7	2021	Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001).	Poly I-C	34-44	chemokine (C-X-C motif) ligand 15	Mus musculus	165-168
34028652-7	2021	Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001).	Poly I-C	34-44	tumor necrosis factor	Mus musculus	174-182
34009721-6	2021	Poly(I:C) triggered a type I IFN response characterized by IFN-regulatory factors gene upregulation, IFN-beta secretion, and STAT1 activation.	Poly I-C	0-9	IFN1@	Homo sapiens	101-109
34009721-6	2021	Poly(I:C) triggered a type I IFN response characterized by IFN-regulatory factors gene upregulation, IFN-beta secretion, and STAT1 activation.	Poly I-C	0-9	signal transducer and activator of transcription 1	Homo sapiens	125-130
34015428-5	2021	Single exposure of slice cultures to TLR2 or TLR3 ligands [PGN, poly(I:C)] for 2-3 days induced moderate microglial activation featuring IL-6 and TNF-alpha release and only mild alterations of fast neuronal gamma band oscillations (30-70 Hz) that are fundamental to higher cognitive functions, such as perception, memory and behavior.	Poly I-C	64-73	toll-like receptor 2	Rattus norvegicus	37-41
34001091-0	2021	ORMDL3 regulates poly I:C induced inflammatory responses in airway epithelial cells.	Poly I-C	17-25	ORMDL sphingolipid biosynthesis regulator 3	Homo sapiens	0-6
34001091-2	2021	Polyinosinic-polycytidylic acid (poly I:C) is a synthetic analog of viral double-stranded RNA, a toll-like receptor 3 (TLR3) ligand and mimic of viral infection.	Poly I-C	0-31	toll like receptor 3	Homo sapiens	97-117
34001091-2	2021	Polyinosinic-polycytidylic acid (poly I:C) is a synthetic analog of viral double-stranded RNA, a toll-like receptor 3 (TLR3) ligand and mimic of viral infection.	Poly I-C	0-31	toll like receptor 3	Homo sapiens	119-123
34001091-2	2021	Polyinosinic-polycytidylic acid (poly I:C) is a synthetic analog of viral double-stranded RNA, a toll-like receptor 3 (TLR3) ligand and mimic of viral infection.	Poly I-C	33-41	toll like receptor 3	Homo sapiens	97-117
34015428-5	2021	Single exposure of slice cultures to TLR2 or TLR3 ligands [PGN, poly(I:C)] for 2-3 days induced moderate microglial activation featuring IL-6 and TNF-alpha release and only mild alterations of fast neuronal gamma band oscillations (30-70 Hz) that are fundamental to higher cognitive functions, such as perception, memory and behavior.	Poly I-C	64-73	toll-like receptor 3	Rattus norvegicus	45-49
34015428-5	2021	Single exposure of slice cultures to TLR2 or TLR3 ligands [PGN, poly(I:C)] for 2-3 days induced moderate microglial activation featuring IL-6 and TNF-alpha release and only mild alterations of fast neuronal gamma band oscillations (30-70 Hz) that are fundamental to higher cognitive functions, such as perception, memory and behavior.	Poly I-C	64-73	interleukin 6	Rattus norvegicus	137-141
34015428-5	2021	Single exposure of slice cultures to TLR2 or TLR3 ligands [PGN, poly(I:C)] for 2-3 days induced moderate microglial activation featuring IL-6 and TNF-alpha release and only mild alterations of fast neuronal gamma band oscillations (30-70 Hz) that are fundamental to higher cognitive functions, such as perception, memory and behavior.	Poly I-C	64-73	tumor necrosis factor	Rattus norvegicus	146-155
33984607-9	2021	Furthermore, stimulating normal mouse spleen NK cells with poly I:C resulted in elevated expression of CXCR1 and interferon-gamma release.	Poly I-C	59-67	chemokine (C-X-C motif) receptor 1	Mus musculus	103-108
34001091-2	2021	Polyinosinic-polycytidylic acid (poly I:C) is a synthetic analog of viral double-stranded RNA, a toll-like receptor 3 (TLR3) ligand and mimic of viral infection.	Poly I-C	33-41	toll like receptor 3	Homo sapiens	119-123
34001091-8	2021	Time course studies showed that ORMDL3-deficient A549 and NHBE cells had an attenuated IL-6 and IL-8 response to poly I:C stimulation.	Poly I-C	113-121	ORMDL sphingolipid biosynthesis regulator 3	Homo sapiens	32-38
34001091-8	2021	Time course studies showed that ORMDL3-deficient A549 and NHBE cells had an attenuated IL-6 and IL-8 response to poly I:C stimulation.	Poly I-C	113-121	interleukin 6	Homo sapiens	87-91
34001091-8	2021	Time course studies showed that ORMDL3-deficient A549 and NHBE cells had an attenuated IL-6 and IL-8 response to poly I:C stimulation.	Poly I-C	113-121	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
34001091-9	2021	A549 and NHBE cells over-expressing ORMDL3 released relatively more IL-6 and IL-8 following poly I:C stimulation.	Poly I-C	92-100	ORMDL sphingolipid biosynthesis regulator 3	Homo sapiens	36-42
34001091-9	2021	A549 and NHBE cells over-expressing ORMDL3 released relatively more IL-6 and IL-8 following poly I:C stimulation.	Poly I-C	92-100	interleukin 6	Homo sapiens	68-72
34001091-11	2021	Transcript abundance of IFNB following poly I:C stimulation was not significantly altered by ORMDL3 knockdown or over-expression.	Poly I-C	39-47	interferon beta 1	Homo sapiens	24-28
33988261-0	2021	Poly(I:C) enhances the efficacy of phagocytosis checkpoint blockade immunotherapy by inducing IL-6 production.	Poly I-C	0-9	interleukin 6	Homo sapiens	94-98
33988261-3	2021	Here, we show that polyinosinic-polycytidylic acid (Poly(I:C)), a synthetic analog of double-stranded RNA, enhances the antitumor activity of CD47 blockade in colorectal cancer in vitro and in vivo.	Poly I-C	19-50	CD47 molecule	Homo sapiens	142-146
33988261-3	2021	Here, we show that polyinosinic-polycytidylic acid (Poly(I:C)), a synthetic analog of double-stranded RNA, enhances the antitumor activity of CD47 blockade in colorectal cancer in vitro and in vivo.	Poly I-C	52-61	CD47 molecule	Homo sapiens	142-146
33988261-4	2021	Poly(I:C) activation leads to a potent immune response characterized by the production of proinflammatory cytokines, especially IL-6.	Poly I-C	0-9	interleukin 6	Homo sapiens	128-132
33988261-6	2021	Our findings demonstrate the potential of Poly(I:C) to synergize the efficacy of CD47 blockade therapy and a novel role for IL-6 in macrophage phagocytosis, which provide new strategy for combinational cancer immunotherapy.	Poly I-C	42-51	CD47 molecule	Homo sapiens	81-85
33984607-9	2021	Furthermore, stimulating normal mouse spleen NK cells with poly I:C resulted in elevated expression of CXCR1 and interferon-gamma release.	Poly I-C	59-67	interferon gamma	Mus musculus	113-129
33894039-10	2021	Moreover, silencing ZAP decreased IFN regulatory factor 3 (IRF3) phosphorylation in HEV-infected cells treated with poly(I:C), indicating that ZAP synergizes with IFN-beta.	Poly I-C	116-125	zinc finger CCCH-type containing, antiviral 1	Homo sapiens	20-23
33744653-12	2021	Also, On-NKEF-A was markedly induced post S. agalactiae, LPS and poly I:C stimulation in head kidney-derived NCC.	Poly I-C	65-73	macrophage stimulating 1 receptor	Rattus norvegicus	6-8
33902571-4	2021	Our objective was to Characterize a model of peripheral blood mononuclear cells (PBMCs) of patients with severe asthma (SA) and its response to the TLR3 agonist Poly I:C using two single-cell methods.	Poly I-C	161-169	toll like receptor 3	Homo sapiens	148-152
33902571-11	2021	CyTOF profiling of Poly I:C stimulated and unstimulated PBMCs (n = 160,000) from the same individuals (SA = 5; HC = 3) demonstrated higher CD8 + and CD8 + effector T cells in SA at baseline, followed by a decrease of CD8 + effector T cells after poly I:C stimulation.	Poly I-C	19-27	CD8a molecule	Homo sapiens	139-142
33902571-11	2021	CyTOF profiling of Poly I:C stimulated and unstimulated PBMCs (n = 160,000) from the same individuals (SA = 5; HC = 3) demonstrated higher CD8 + and CD8 + effector T cells in SA at baseline, followed by a decrease of CD8 + effector T cells after poly I:C stimulation.	Poly I-C	19-27	CD8a molecule	Homo sapiens	149-152
33902571-11	2021	CyTOF profiling of Poly I:C stimulated and unstimulated PBMCs (n = 160,000) from the same individuals (SA = 5; HC = 3) demonstrated higher CD8 + and CD8 + effector T cells in SA at baseline, followed by a decrease of CD8 + effector T cells after poly I:C stimulation.	Poly I-C	19-27	CD8a molecule	Homo sapiens	149-152
33342034-5	2021	Here we showed that transfection of polyI:C suppressed TGF-beta signaling in a MDA5- and RIG-I-dependent manner.	Poly I-C	36-43	transforming growth factor alpha	Mus musculus	55-63
33342034-5	2021	Here we showed that transfection of polyI:C suppressed TGF-beta signaling in a MDA5- and RIG-I-dependent manner.	Poly I-C	36-43	interferon induced with helicase C domain 1	Mus musculus	79-83
33342034-5	2021	Here we showed that transfection of polyI:C suppressed TGF-beta signaling in a MDA5- and RIG-I-dependent manner.	Poly I-C	36-43	DEAD/H box helicase 58	Mus musculus	89-94
33342034-6	2021	We found that suppression of TGF-beta signaling by polyI:C promoted cancer cell death, which was attenuated by forced expression of constitutively active Smad3.	Poly I-C	51-58	transforming growth factor alpha	Mus musculus	29-37
33342034-6	2021	We found that suppression of TGF-beta signaling by polyI:C promoted cancer cell death, which was attenuated by forced expression of constitutively active Smad3.	Poly I-C	51-58	SMAD family member 3	Mus musculus	154-159
33342034-9	2021	These results indicated that intra-tumor administration of polyI:C and related dsRNA analogues may be promising treatments for triple negative breast cancer through inhibition of the anti-pyroptotic function of TGF-beta.	Poly I-C	59-66	transforming growth factor alpha	Mus musculus	211-219
33911136-7	2021	In contrast, phosphomimetic mutations (Ser-to-Asp) inhibited PKR activation following either poly (I:C) transfection or virus infection.	Poly I-C	93-103	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	61-64
33981629-0	2021	Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells.	Poly I-C	34-43	angiotensin converting enzyme 2	Homo sapiens	52-56
33981629-8	2021	Results: Among the TLR agonists, the TLR3 agonist Poly(I:C) significantly increased ACE2 and TMPRSS2 mRNA expression in HNECs (ACE2 36.212+-11.600-fold change, p<0.0001; TMPRSS2 5.598+-2.434-fold change, p=0.031).	Poly I-C	50-59	toll like receptor 3	Homo sapiens	19-22
33981629-8	2021	Results: Among the TLR agonists, the TLR3 agonist Poly(I:C) significantly increased ACE2 and TMPRSS2 mRNA expression in HNECs (ACE2 36.212+-11.600-fold change, p<0.0001; TMPRSS2 5.598+-2.434-fold change, p=0.031).	Poly I-C	50-59	toll like receptor 3	Homo sapiens	37-41
33981629-8	2021	Results: Among the TLR agonists, the TLR3 agonist Poly(I:C) significantly increased ACE2 and TMPRSS2 mRNA expression in HNECs (ACE2 36.212+-11.600-fold change, p<0.0001; TMPRSS2 5.598+-2.434-fold change, p=0.031).	Poly I-C	50-59	angiotensin converting enzyme 2	Homo sapiens	84-88
33981629-8	2021	Results: Among the TLR agonists, the TLR3 agonist Poly(I:C) significantly increased ACE2 and TMPRSS2 mRNA expression in HNECs (ACE2 36.212+-11.600-fold change, p<0.0001; TMPRSS2 5.598+-2.434-fold change, p=0.031).	Poly I-C	50-59	transmembrane serine protease 2	Homo sapiens	93-100
33981629-8	2021	Results: Among the TLR agonists, the TLR3 agonist Poly(I:C) significantly increased ACE2 and TMPRSS2 mRNA expression in HNECs (ACE2 36.212+-11.600-fold change, p<0.0001; TMPRSS2 5.598+-2.434-fold change, p=0.031).	Poly I-C	50-59	angiotensin converting enzyme 2	Homo sapiens	127-131
33981629-8	2021	Results: Among the TLR agonists, the TLR3 agonist Poly(I:C) significantly increased ACE2 and TMPRSS2 mRNA expression in HNECs (ACE2 36.212+-11.600-fold change, p<0.0001; TMPRSS2 5.598+-2.434-fold change, p=0.031).	Poly I-C	50-59	transmembrane serine protease 2	Homo sapiens	170-177
33981629-9	2021	The ACE2 protein level was also increased with Poly(I:C) stimulation (2.884+-0.505-fold change, p=0.003).	Poly I-C	47-56	angiotensin converting enzyme 2	Homo sapiens	4-8
33981629-10	2021	The Poly(I:C)-induced ACE2 expression was suppressed by co-incubation with FP (0.405+-0.312-fold change, p=0.044).	Poly I-C	4-13	angiotensin converting enzyme 2	Homo sapiens	22-26
33899078-5	2021	These PRRs can be activated by their respective ligands: lipopolysaccharide (LPS) and flagellin of Gram-negative bacteria for TLR4 and TLR5, polyinosinic-polycytidylic acid (poly(I:C)) for TLR3 and MDA5, and herpes simplex virus DNA analog (HSV60) for p204.	Poly I-C	141-172	toll-like receptor 3	Mus musculus	189-193
33899078-5	2021	These PRRs can be activated by their respective ligands: lipopolysaccharide (LPS) and flagellin of Gram-negative bacteria for TLR4 and TLR5, polyinosinic-polycytidylic acid (poly(I:C)) for TLR3 and MDA5, and herpes simplex virus DNA analog (HSV60) for p204.	Poly I-C	141-172	interferon induced with helicase C domain 1	Mus musculus	198-202
33899078-5	2021	These PRRs can be activated by their respective ligands: lipopolysaccharide (LPS) and flagellin of Gram-negative bacteria for TLR4 and TLR5, polyinosinic-polycytidylic acid (poly(I:C)) for TLR3 and MDA5, and herpes simplex virus DNA analog (HSV60) for p204.	Poly I-C	141-172	interferon activated gene 204	Mus musculus	252-256
33899078-5	2021	These PRRs can be activated by their respective ligands: lipopolysaccharide (LPS) and flagellin of Gram-negative bacteria for TLR4 and TLR5, polyinosinic-polycytidylic acid (poly(I:C)) for TLR3 and MDA5, and herpes simplex virus DNA analog (HSV60) for p204.	Poly I-C	174-183	toll-like receptor 3	Mus musculus	189-193
33899078-5	2021	These PRRs can be activated by their respective ligands: lipopolysaccharide (LPS) and flagellin of Gram-negative bacteria for TLR4 and TLR5, polyinosinic-polycytidylic acid (poly(I:C)) for TLR3 and MDA5, and herpes simplex virus DNA analog (HSV60) for p204.	Poly I-C	174-183	interferon induced with helicase C domain 1	Mus musculus	198-202
33899078-5	2021	These PRRs can be activated by their respective ligands: lipopolysaccharide (LPS) and flagellin of Gram-negative bacteria for TLR4 and TLR5, polyinosinic-polycytidylic acid (poly(I:C)) for TLR3 and MDA5, and herpes simplex virus DNA analog (HSV60) for p204.	Poly I-C	174-183	interferon activated gene 204	Mus musculus	252-256
33894039-10	2021	Moreover, silencing ZAP decreased IFN regulatory factor 3 (IRF3) phosphorylation in HEV-infected cells treated with poly(I:C), indicating that ZAP synergizes with IFN-beta.	Poly I-C	116-125	interferon regulatory factor 3	Homo sapiens	59-63
33894039-10	2021	Moreover, silencing ZAP decreased IFN regulatory factor 3 (IRF3) phosphorylation in HEV-infected cells treated with poly(I:C), indicating that ZAP synergizes with IFN-beta.	Poly I-C	116-125	zinc finger CCCH-type containing, antiviral 1	Homo sapiens	143-146
33894039-10	2021	Moreover, silencing ZAP decreased IFN regulatory factor 3 (IRF3) phosphorylation in HEV-infected cells treated with poly(I:C), indicating that ZAP synergizes with IFN-beta.	Poly I-C	116-125	IFN1@	Homo sapiens	163-171
33626380-6	2021	Moreover, both orf8L and orf8S of SARS-CoV-2 are capable of down regulating the production of IFNss and interferon-stimulated genes (ISG), ISG15 and ISG56 induced by polyinosinic-polycytidylic acid (poly (I:C)).	Poly I-C	166-197	ISG15 ubiquitin like modifier	Homo sapiens	139-144
33892139-6	2021	High molecular weight (HMW) poly I:C (1-6kb, 12 mg/kg) produced more robust sickness behavior and more robust IL-6, IFN-I and TNF-alpha responses than poly I:C of <500 bases (low MW) preparations.	Poly I-C	28-36	interleukin 6	Mus musculus	110-114
33892139-6	2021	High molecular weight (HMW) poly I:C (1-6kb, 12 mg/kg) produced more robust sickness behavior and more robust IL-6, IFN-I and TNF-alpha responses than poly I:C of <500 bases (low MW) preparations.	Poly I-C	28-36	tumor necrosis factor	Mus musculus	126-135
33892139-8	2021	In aged animals, poly I:C induced exaggerated IL-6, IL-1beta and IFN-I in the plasma and similar exaggerated brain cytokine responses.	Poly I-C	17-25	interleukin 6	Mus musculus	46-50
33892139-8	2021	In aged animals, poly I:C induced exaggerated IL-6, IL-1beta and IFN-I in the plasma and similar exaggerated brain cytokine responses.	Poly I-C	17-25	interleukin 1 alpha	Mus musculus	52-60
33626380-6	2021	Moreover, both orf8L and orf8S of SARS-CoV-2 are capable of down regulating the production of IFNss and interferon-stimulated genes (ISG), ISG15 and ISG56 induced by polyinosinic-polycytidylic acid (poly (I:C)).	Poly I-C	166-197	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	149-154
33626380-6	2021	Moreover, both orf8L and orf8S of SARS-CoV-2 are capable of down regulating the production of IFNss and interferon-stimulated genes (ISG), ISG15 and ISG56 induced by polyinosinic-polycytidylic acid (poly (I:C)).	Poly I-C	199-209	ISG15 ubiquitin like modifier	Homo sapiens	139-144
33626380-6	2021	Moreover, both orf8L and orf8S of SARS-CoV-2 are capable of down regulating the production of IFNss and interferon-stimulated genes (ISG), ISG15 and ISG56 induced by polyinosinic-polycytidylic acid (poly (I:C)).	Poly I-C	199-209	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	149-154
33626380-7	2021	Moreover, we also found decreased nuclear translocation of Interferon regulatory factor 3 (IRF3), after overexpressing orf8L and orf8S induced by poly (I:C).	Poly I-C	146-156	interferon regulatory factor 3	Homo sapiens	59-89
33626380-7	2021	Moreover, we also found decreased nuclear translocation of Interferon regulatory factor 3 (IRF3), after overexpressing orf8L and orf8S induced by poly (I:C).	Poly I-C	146-156	interferon regulatory factor 3	Homo sapiens	91-95
33486326-5	2021	Over-expression of PEDV E protein significantly inhibited poly(I:C)-induced IFN-beta and IFN-stimulated genes (ISGs) productions.	Poly I-C	58-67	IFN1@	Homo sapiens	76-84
33928105-8	2021	Accompanied by elevated expression of IFN cytokines and IL-33, Th1 activation was enhanced in SMG of poly(I:C)-treated NOD mice, but Th17 cells activation was unchanged among the groups.	Poly I-C	101-110	interleukin 33	Mus musculus	56-61
33928105-9	2021	In addition, intratracheal poly(I:C) exposure promoted the expression of IL-33 and increased T cells proportion in the lung, which were consistent with the change in SMG.	Poly I-C	27-36	interleukin 33	Mus musculus	73-78
33837043-2	2021	In this study, we show that PCC was also able to sensitize melanoma and renal carcinoma cells to apoptosis in response not only to TRAIL, but also to the synthetic polynucleotide poly I:C, a viral mimetic and immune activator, by reducing levels of anti-apoptotic proteins cFLIP and Livin.	Poly I-C	179-187	baculoviral IAP repeat containing 7	Homo sapiens	283-288
33706396-0	2021	Protective Role of Activated Protein C against Viral Mimetic Poly(I:C)-Induced Inflammation.	Poly I-C	61-70	APC, WNT signaling pathway regulator	Mus musculus	19-38
33706396-3	2021	Poly(I:C) induced histone H3 extranuclear translocation via interaction with toll-like receptor 3 in two established endothelial cell lines.	Poly I-C	0-9	toll-like receptor 3	Mus musculus	77-97
33706396-7	2021	In vivo, poly(I:C) enhanced cell surface expression of Mac-1 on neutrophils in mice and facilitated their infiltration to lung tissues.	Poly I-C	9-18	integrin alpha M	Mus musculus	55-60
33706396-8	2021	Poly(I:C) also downregulated thrombomodulin expression in mouse tissues and reduced its circulating soluble level in plasma.	Poly I-C	0-9	thrombomodulin	Mus musculus	29-43
33921475-5	2021	We found that co-culture of iDCs with differentially activated LAD2 MCs in serum-containing media significantly modulated polyinosinic:polycytidylic acid (poly I:C)-elicited DC maturation as determined through the surface expression of the maturation markers CD80, CD83, CD86, and human leukocyte antigen(HLA)-DR. Once iDCs were generated in serum-free conditions, they became refractory to the maturation with poly I:C, and the LAD2 MC modulatory potential was minimized.	Poly I-C	155-163	CD80 molecule	Homo sapiens	259-263
33921475-5	2021	We found that co-culture of iDCs with differentially activated LAD2 MCs in serum-containing media significantly modulated polyinosinic:polycytidylic acid (poly I:C)-elicited DC maturation as determined through the surface expression of the maturation markers CD80, CD83, CD86, and human leukocyte antigen(HLA)-DR. Once iDCs were generated in serum-free conditions, they became refractory to the maturation with poly I:C, and the LAD2 MC modulatory potential was minimized.	Poly I-C	155-163	CD83 molecule	Homo sapiens	265-269
33921475-5	2021	We found that co-culture of iDCs with differentially activated LAD2 MCs in serum-containing media significantly modulated polyinosinic:polycytidylic acid (poly I:C)-elicited DC maturation as determined through the surface expression of the maturation markers CD80, CD83, CD86, and human leukocyte antigen(HLA)-DR. Once iDCs were generated in serum-free conditions, they became refractory to the maturation with poly I:C, and the LAD2 MC modulatory potential was minimized.	Poly I-C	155-163	CD86 molecule	Homo sapiens	271-275
33830434-4	2021	Further, ISG20 expression was upregulated following PRV infection and poly(I:C) treatment.	Poly I-C	70-79	interferon stimulated exonuclease gene 20	Homo sapiens	9-14
33058491-10	2021	SGECs stimulated with poly(I:C), IFNalpha, or IFNgamma secreted IL-7.	Poly I-C	22-31	interleukin 7	Homo sapiens	64-68
33637958-4	2021	SARS-CoV-2 nsp12 attenuated Sendai virus (SeV)- or poly(I:C)-induced IFN-beta promoter activation in a dose-dependent manner.	Poly I-C	51-60	IFN1@	Homo sapiens	69-77
33387560-6	2021	The transcription levels of OnTIRAP and OnTRIF were upregulated in response to bacterial and poly (I:C) challenges.	Poly I-C	93-103	toll/interleukin-1 receptor domain-containing adapter protein	Oreochromis niloticus	28-35
33732901-8	2021	We also show that the expression of interferon-beta was upregulated in the placenta after maternal injection with poly (I:C).	Poly I-C	114-124	interferon beta 1, fibroblast	Mus musculus	36-51
33486326-7	2021	Furthermore, PEDV E protein obviously interfered with the translocation of IRF3 from cytoplasm to nucleus through direct interaction with IRF3, which is crucial for the IFN-beta production induced by poly(I:C).	Poly I-C	200-209	interferon regulatory factor 3	Homo sapiens	75-79
33486326-7	2021	Furthermore, PEDV E protein obviously interfered with the translocation of IRF3 from cytoplasm to nucleus through direct interaction with IRF3, which is crucial for the IFN-beta production induced by poly(I:C).	Poly I-C	200-209	interferon regulatory factor 3	Homo sapiens	138-142
33486326-7	2021	Furthermore, PEDV E protein obviously interfered with the translocation of IRF3 from cytoplasm to nucleus through direct interaction with IRF3, which is crucial for the IFN-beta production induced by poly(I:C).	Poly I-C	200-209	IFN1@	Homo sapiens	169-177
33577621-3	2021	In this study, we identified the PB1 protein of H7N9 virus as a new negative regulator of virus- or poly(I:C)-stimulated IFN induction and specifically interacted with and destabilized MAVS.	Poly I-C	100-109	submaxillary gland androgen regulated protein 3A	Homo sapiens	33-36
33583094-7	2021	Interestingly, when keratinocytes were stimulated with a TLR3 agonist, RGRN-305 also demonstrated potent immunomodulatory effects, significantly inhibiting poly(I:C)-induced expression of the proinflammatory genes TNFalpha, IL1B, IL6, and IL23A.	Poly I-C	156-165	toll like receptor 3	Homo sapiens	57-61
33583094-7	2021	Interestingly, when keratinocytes were stimulated with a TLR3 agonist, RGRN-305 also demonstrated potent immunomodulatory effects, significantly inhibiting poly(I:C)-induced expression of the proinflammatory genes TNFalpha, IL1B, IL6, and IL23A.	Poly I-C	156-165	tumor necrosis factor	Homo sapiens	214-222
33583094-7	2021	Interestingly, when keratinocytes were stimulated with a TLR3 agonist, RGRN-305 also demonstrated potent immunomodulatory effects, significantly inhibiting poly(I:C)-induced expression of the proinflammatory genes TNFalpha, IL1B, IL6, and IL23A.	Poly I-C	156-165	interleukin 1 beta	Homo sapiens	224-228
33583094-7	2021	Interestingly, when keratinocytes were stimulated with a TLR3 agonist, RGRN-305 also demonstrated potent immunomodulatory effects, significantly inhibiting poly(I:C)-induced expression of the proinflammatory genes TNFalpha, IL1B, IL6, and IL23A.	Poly I-C	156-165	interleukin 6	Homo sapiens	230-233
33583094-7	2021	Interestingly, when keratinocytes were stimulated with a TLR3 agonist, RGRN-305 also demonstrated potent immunomodulatory effects, significantly inhibiting poly(I:C)-induced expression of the proinflammatory genes TNFalpha, IL1B, IL6, and IL23A.	Poly I-C	156-165	interleukin 23 subunit alpha	Homo sapiens	239-244
33708102-6	2021	The Poly I:C treatment induced the expression and secretion of different cytokines belonging to the CCL- and CXCL-motif chemokine family as well as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).	Poly I-C	4-12	interleukin 6	Homo sapiens	148-161
33708102-6	2021	The Poly I:C treatment induced the expression and secretion of different cytokines belonging to the CCL- and CXCL-motif chemokine family as well as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).	Poly I-C	4-12	interleukin 6	Homo sapiens	163-167
33708102-6	2021	The Poly I:C treatment induced the expression and secretion of different cytokines belonging to the CCL- and CXCL-motif chemokine family as well as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).	Poly I-C	4-12	tumor necrosis factor	Homo sapiens	173-200
33708102-6	2021	The Poly I:C treatment induced the expression and secretion of different cytokines belonging to the CCL- and CXCL-motif chemokine family as well as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).	Poly I-C	4-12	tumor necrosis factor	Homo sapiens	202-211
33603190-9	2021	Thus, CLEC18A is a TLR3 co-receptor, and may contribute to the differential immune responses to poly (I:C) and IAV infection between human and mouse.	Poly I-C	96-106	C-type lectin domain family 18 member A	Homo sapiens	6-13
33673382-7	2021	SLA archaeosomes were tested alone or in combination with the toll-like receptor 3 (TLR3) agonist Poly(I:C).	Poly I-C	98-107	toll-like receptor 3	Mus musculus	62-82
33673382-7	2021	SLA archaeosomes were tested alone or in combination with the toll-like receptor 3 (TLR3) agonist Poly(I:C).	Poly I-C	98-107	toll-like receptor 3	Mus musculus	84-88
33558485-9	2021	These observations were confirmed in OL primary cultures: cells treated with TLR3 agonist Poly(I:C) during differentiation showed a stronger upregulation of Ccl2 and Cxcl10 compared to cells treated during proliferation and led to decreased expression of myelin genes.	Poly I-C	90-99	toll-like receptor 3	Mus musculus	77-81
33459340-3	2021	Another dsRNA binding protein PACT, originally identified as the cellular protein activator of dsRNA-activated protein kinase (PKR), is known to enhance RIG-I signaling in response to polyI:C treatment, in part by stimulating RIG-I"s ATPase and helicase activities.	Poly I-C	184-191	protein activator of interferon induced protein kinase EIF2AK2	Homo sapiens	30-34
33459340-3	2021	Another dsRNA binding protein PACT, originally identified as the cellular protein activator of dsRNA-activated protein kinase (PKR), is known to enhance RIG-I signaling in response to polyI:C treatment, in part by stimulating RIG-I"s ATPase and helicase activities.	Poly I-C	184-191	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	127-130
33459340-3	2021	Another dsRNA binding protein PACT, originally identified as the cellular protein activator of dsRNA-activated protein kinase (PKR), is known to enhance RIG-I signaling in response to polyI:C treatment, in part by stimulating RIG-I"s ATPase and helicase activities.	Poly I-C	184-191	DExD/H-box helicase 58	Homo sapiens	153-158
33459340-3	2021	Another dsRNA binding protein PACT, originally identified as the cellular protein activator of dsRNA-activated protein kinase (PKR), is known to enhance RIG-I signaling in response to polyI:C treatment, in part by stimulating RIG-I"s ATPase and helicase activities.	Poly I-C	184-191	DExD/H-box helicase 58	Homo sapiens	226-231
33459340-3	2021	Another dsRNA binding protein PACT, originally identified as the cellular protein activator of dsRNA-activated protein kinase (PKR), is known to enhance RIG-I signaling in response to polyI:C treatment, in part by stimulating RIG-I"s ATPase and helicase activities.	Poly I-C	184-191	helicase for meiosis 1	Homo sapiens	245-253
33558485-9	2021	These observations were confirmed in OL primary cultures: cells treated with TLR3 agonist Poly(I:C) during differentiation showed a stronger upregulation of Ccl2 and Cxcl10 compared to cells treated during proliferation and led to decreased expression of myelin genes.	Poly I-C	90-99	chemokine (C-C motif) ligand 2	Mus musculus	157-161
33558485-9	2021	These observations were confirmed in OL primary cultures: cells treated with TLR3 agonist Poly(I:C) during differentiation showed a stronger upregulation of Ccl2 and Cxcl10 compared to cells treated during proliferation and led to decreased expression of myelin genes.	Poly I-C	90-99	chemokine (C-X-C motif) ligand 10	Mus musculus	166-172
33540061-0	2021	Delivery of Toll-Like Receptor 3 Ligand Poly(I:C) to the Liver by Calcium Phosphate Nanoparticles Conjugated with an F4/80 Antibody Exerts an Anti-Hepatitis B Virus Effect in a Mouse Model.	Poly I-C	40-49	toll like receptor 3	Homo sapiens	12-32
33540932-5	2021	Both humoral and cellular immune responses were greatly enhanced compared to either adjuvant alone when SLA archaeosomes were combined with either the TLR3 agonist poly(I:C) or the TLR9 agonist CpG.	Poly I-C	164-173	toll-like receptor 3	Mus musculus	151-155
33540061-0	2021	Delivery of Toll-Like Receptor 3 Ligand Poly(I:C) to the Liver by Calcium Phosphate Nanoparticles Conjugated with an F4/80 Antibody Exerts an Anti-Hepatitis B Virus Effect in a Mouse Model.	Poly I-C	40-49	adhesion G protein-coupled receptor E1	Mus musculus	117-122
33046534-3	2021	Here, we show that immunotherapy with a ligand of Toll-like receptor-3 (TLR3), polyinosinic:polycytidylic acid (pIC), restores the deficient response to chemotherapy of tumors lacking ANXA1 developing in immunocompetent mice or that of normal cancers growing in FPR1-deficient mice.	Poly I-C	112-115	toll-like receptor 3	Mus musculus	50-70
33485214-6	2021	Then, BMDM acts as a living cell drug vehicle and promotes the accumulation of PLP NPs in tumors, where Poly I: C is released from PLP NPs and reprograms BMDM into tumoricidal M1 macrophage.	Poly I-C	104-113	proteolipid protein 1	Homo sapiens	79-82
33485214-6	2021	Then, BMDM acts as a living cell drug vehicle and promotes the accumulation of PLP NPs in tumors, where Poly I: C is released from PLP NPs and reprograms BMDM into tumoricidal M1 macrophage.	Poly I-C	104-113	proteolipid protein 1	Homo sapiens	131-134
33046534-3	2021	Here, we show that immunotherapy with a ligand of Toll-like receptor-3 (TLR3), polyinosinic:polycytidylic acid (pIC), restores the deficient response to chemotherapy of tumors lacking ANXA1 developing in immunocompetent mice or that of normal cancers growing in FPR1-deficient mice.	Poly I-C	112-115	toll-like receptor 3	Mus musculus	72-76
33046534-3	2021	Here, we show that immunotherapy with a ligand of Toll-like receptor-3 (TLR3), polyinosinic:polycytidylic acid (pIC), restores the deficient response to chemotherapy of tumors lacking ANXA1 developing in immunocompetent mice or that of normal cancers growing in FPR1-deficient mice.	Poly I-C	112-115	annexin A1	Mus musculus	184-189
33046534-3	2021	Here, we show that immunotherapy with a ligand of Toll-like receptor-3 (TLR3), polyinosinic:polycytidylic acid (pIC), restores the deficient response to chemotherapy of tumors lacking ANXA1 developing in immunocompetent mice or that of normal cancers growing in FPR1-deficient mice.	Poly I-C	112-115	formyl peptide receptor 1	Mus musculus	262-266
33402730-7	2022	We combine here proprotein convertases inhibitor with Poly (I:C), a TLR3 ligand, to increase the anti-tumoral activity of macrophages.	Poly I-C	54-64	toll like receptor 3	Homo sapiens	68-72
31729464-6	2021	Myeloid cell-specific Cul4b knockout mice were more susceptible to septic shock when challenged with lipopolysaccharide, polyinosinic-polycytidylic acid or Salmonella typhimurium infection.	Poly I-C	121-152	cullin 4B	Mus musculus	22-27
33452755-11	2021	The geranylgeranyl transferase inhibitor suppressed poly(I:C)-induced expression of IFN-beta and ISGs and phosphorylation of IRF3 and STAT1.	Poly I-C	52-61	interferon alpha	Mus musculus	84-92
33452755-11	2021	The geranylgeranyl transferase inhibitor suppressed poly(I:C)-induced expression of IFN-beta and ISGs and phosphorylation of IRF3 and STAT1.	Poly I-C	52-61	interferon regulatory factor 3	Mus musculus	125-129
33452755-11	2021	The geranylgeranyl transferase inhibitor suppressed poly(I:C)-induced expression of IFN-beta and ISGs and phosphorylation of IRF3 and STAT1.	Poly I-C	52-61	signal transducer and activator of transcription 1	Mus musculus	134-139
33452755-12	2021	These results suggest that statins suppressed the expression of IFN-beta and ISGs in poly(I:C)-treated hyperlipidemic mice and murine macrophages, and that these effects occurred through the inhibition of IRF3 and JAK/STAT signaling in macrophages.	Poly I-C	85-94	interferon alpha	Mus musculus	64-72
33452755-12	2021	These results suggest that statins suppressed the expression of IFN-beta and ISGs in poly(I:C)-treated hyperlipidemic mice and murine macrophages, and that these effects occurred through the inhibition of IRF3 and JAK/STAT signaling in macrophages.	Poly I-C	85-94	interferon regulatory factor 3	Mus musculus	205-209
33452755-12	2021	These results suggest that statins suppressed the expression of IFN-beta and ISGs in poly(I:C)-treated hyperlipidemic mice and murine macrophages, and that these effects occurred through the inhibition of IRF3 and JAK/STAT signaling in macrophages.	Poly I-C	85-94	signal transducer and activator of transcription 1	Mus musculus	218-222
33452755-13	2021	Furthermore, GGPP recovered the statin-suppressed IRF3 and JAK/STAT signaling in poly(I:C)-treated macrophages.	Poly I-C	81-90	interferon regulatory factor 3	Mus musculus	50-54
33452755-13	2021	Furthermore, GGPP recovered the statin-suppressed IRF3 and JAK/STAT signaling in poly(I:C)-treated macrophages.	Poly I-C	81-90	signal transducer and activator of transcription 1	Mus musculus	63-67
33505391-8	2020	We established high-throughput automation compatible methods for standardized primary fibroblast cell activation, using purified MAMPS analogs, poly I:C and LPS that stimulate TLR3 and TLR4 pathways respectively.	Poly I-C	144-152	toll like receptor 3	Homo sapiens	176-180
33505391-8	2020	We established high-throughput automation compatible methods for standardized primary fibroblast cell activation, using purified MAMPS analogs, poly I:C and LPS that stimulate TLR3 and TLR4 pathways respectively.	Poly I-C	144-152	toll like receptor 4	Homo sapiens	185-189
33442686-6	2021	High molecular weight (HMW) poly I:C (1 to 6 kb, 12 mg/kg) produced more robust sickness behavior and more robust IL-6, IFN-I and TNF alpha responses than poly I:C of less than 500 bases (low MW) preparations.	Poly I-C	28-36	interleukin 6	Mus musculus	114-118
33442686-6	2021	High molecular weight (HMW) poly I:C (1 to 6 kb, 12 mg/kg) produced more robust sickness behavior and more robust IL-6, IFN-I and TNF alpha responses than poly I:C of less than 500 bases (low MW) preparations.	Poly I-C	28-36	tumor necrosis factor	Mus musculus	130-139
33442686-8	2021	In aged animals, poly I:C induced exaggerated IL-6, IL-1beta and IFN-I in the plasma and similar exaggerated brain cytokine responses.	Poly I-C	17-25	interleukin 6	Mus musculus	46-50
33442686-8	2021	In aged animals, poly I:C induced exaggerated IL-6, IL-1beta and IFN-I in the plasma and similar exaggerated brain cytokine responses.	Poly I-C	17-25	interleukin 1 alpha	Mus musculus	52-60
33542218-9	2021	For poly(I:C)-induced cell death, the sensitizing effect of ABIN-1 deficiency on cell death may be attributed to increased expression of TLR3.	Poly I-C	4-13	toll like receptor 3	Homo sapiens	137-141
33007334-6	2021	The subcellular localization results indicated that exogenous IFP35 protein was mainly located in cytoplasm, while endogenous IFP35 protein was transferred into, or aggregated around, the nucleus with induction poly I:C or IFNs.	Poly I-C	211-219	interferon induced protein 35	Homo sapiens	126-131
32875489-2	2021	However, other pathogen-associated molecular patterns, such as zymosan A (Zym) and polyinosinic-polycytidylic acid (Poly I:C), also induce fever in male rats with a different time course of cytokine release and different mediators such as endothelin-1 (ET-1).	Poly I-C	83-114	endothelin 1	Rattus norvegicus	239-251
32875489-2	2021	However, other pathogen-associated molecular patterns, such as zymosan A (Zym) and polyinosinic-polycytidylic acid (Poly I:C), also induce fever in male rats with a different time course of cytokine release and different mediators such as endothelin-1 (ET-1).	Poly I-C	83-114	endothelin 1	Rattus norvegicus	253-257
32491861-4	2021	RIG-I agonists included RNAs derived from Sendai and influenza viral defective interfering RNAs (IVT DI, 3php, respectively) and RIG-I/TLR3 agonist, poly(I:C) (pIC), which induce IFN-Is and TH1-polarized responses.	Poly I-C	149-158	DExD/H-box helicase 58	Homo sapiens	0-5
32491861-4	2021	RIG-I agonists included RNAs derived from Sendai and influenza viral defective interfering RNAs (IVT DI, 3php, respectively) and RIG-I/TLR3 agonist, poly(I:C) (pIC), which induce IFN-Is and TH1-polarized responses.	Poly I-C	149-158	DExD/H-box helicase 58	Homo sapiens	129-134
32491861-4	2021	RIG-I agonists included RNAs derived from Sendai and influenza viral defective interfering RNAs (IVT DI, 3php, respectively) and RIG-I/TLR3 agonist, poly(I:C) (pIC), which induce IFN-Is and TH1-polarized responses.	Poly I-C	149-158	negative elongation factor complex member C/D	Homo sapiens	190-193
33452755-0	2021	Statins attenuate antiviral IFN-beta and ISG expression via inhibition of IRF3 and JAK/STAT signaling in poly(I:C)-treated hyperlipidemic mice and macrophages.	Poly I-C	105-114	interferon alpha	Mus musculus	28-36
33452755-0	2021	Statins attenuate antiviral IFN-beta and ISG expression via inhibition of IRF3 and JAK/STAT signaling in poly(I:C)-treated hyperlipidemic mice and macrophages.	Poly I-C	105-114	interferon regulatory factor 3	Mus musculus	74-78
33452755-0	2021	Statins attenuate antiviral IFN-beta and ISG expression via inhibition of IRF3 and JAK/STAT signaling in poly(I:C)-treated hyperlipidemic mice and macrophages.	Poly I-C	105-114	signal transducer and activator of transcription 1	Mus musculus	87-91
33452755-4	2021	Here, we found that simvastatin decreased polyinosinic-polycytidylic acid [poly(I:C)]-induced expression of antiviral interferon (IFN)-beta and IFN-stimulated genes (ISGs) in the bronchoalveolar lavage fluid (BALF) and lungs of mice with high-fat diet-induced hyperlipidemia.	Poly I-C	75-84	interferon alpha	Mus musculus	118-139
33452755-6	2021	We examined the effects of simvastatin in primary lung macrophages and found that simvastatin suppressed poly(I:C)-induced expression of IFN-beta and ISGs.	Poly I-C	105-114	interferon alpha	Mus musculus	137-145
33452755-8	2021	Simvastatin and pitavastatin decreased poly(I:C)-induced expression of IFN-beta and ISGs.	Poly I-C	39-48	interferon alpha	Mus musculus	71-79
33279564-5	2021	In addition, Xt-IRF1 gene was constitutively expressed in all tissues examined, with the highest expression level observed in spleen, and was inducible after poly(I:C) stimulation.	Poly I-C	158-167	interferon regulatory factor 1	Xenopus tropicalis	16-20
33414457-0	2021	Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections.	Poly I-C	27-36	interleukin 1 family member 10	Homo sapiens	0-14
33414457-4	2021	In the co-cultured human respiratory epithelial cells with macrophages to mimic lung microenvironment in vitro, IL-38 was able to alleviate inflammatory responses by inhibiting poly(I:C)-induced overproduction of pro-inflammatory cytokines and chemokines through intracellular STAT1, STAT3, p38 MAPK, ERK1/2, MEK, and NF-kappaB signaling pathways.	Poly I-C	177-186	interleukin 1 family member 10	Homo sapiens	112-117
33414457-4	2021	In the co-cultured human respiratory epithelial cells with macrophages to mimic lung microenvironment in vitro, IL-38 was able to alleviate inflammatory responses by inhibiting poly(I:C)-induced overproduction of pro-inflammatory cytokines and chemokines through intracellular STAT1, STAT3, p38 MAPK, ERK1/2, MEK, and NF-kappaB signaling pathways.	Poly I-C	177-186	signal transducer and activator of transcription 1	Homo sapiens	277-282
33414457-4	2021	In the co-cultured human respiratory epithelial cells with macrophages to mimic lung microenvironment in vitro, IL-38 was able to alleviate inflammatory responses by inhibiting poly(I:C)-induced overproduction of pro-inflammatory cytokines and chemokines through intracellular STAT1, STAT3, p38 MAPK, ERK1/2, MEK, and NF-kappaB signaling pathways.	Poly I-C	177-186	signal transducer and activator of transcription 3	Homo sapiens	284-289
33414457-4	2021	In the co-cultured human respiratory epithelial cells with macrophages to mimic lung microenvironment in vitro, IL-38 was able to alleviate inflammatory responses by inhibiting poly(I:C)-induced overproduction of pro-inflammatory cytokines and chemokines through intracellular STAT1, STAT3, p38 MAPK, ERK1/2, MEK, and NF-kappaB signaling pathways.	Poly I-C	177-186	mitogen-activated protein kinase 3	Homo sapiens	301-307
33414457-4	2021	In the co-cultured human respiratory epithelial cells with macrophages to mimic lung microenvironment in vitro, IL-38 was able to alleviate inflammatory responses by inhibiting poly(I:C)-induced overproduction of pro-inflammatory cytokines and chemokines through intracellular STAT1, STAT3, p38 MAPK, ERK1/2, MEK, and NF-kappaB signaling pathways.	Poly I-C	177-186	mitogen-activated protein kinase kinase 7	Homo sapiens	309-312
33414457-8	2021	Taken together, our study indicates that IL-38 plays a crucial role in protection from exaggerated pulmonary inflammation during poly(I:C)-induced pneumonia, thereby providing the basis of a novel therapeutic target for respiratory viral infections.	Poly I-C	129-138	interleukin 1 family member 10	Homo sapiens	41-46
33413597-0	2021	The therapeutic efficacy of mesenchymal stromal cells on experimental colitis was improved by the IFN-gamma and poly(I:C) priming through promoting the expression of indoleamine 2,3-dioxygenase.	Poly I-C	112-121	indoleamine 2,3-dioxygenase 1	Mus musculus	166-193
33413597-2	2021	We previously reported that priming of mesenchymal stromal cells (MSCs) with poly(I:C) induced them to express indoleamine 2,3-dioxygenase (IDO).	Poly I-C	77-86	indoleamine 2,3-dioxygenase 1	Mus musculus	111-138
33413597-2	2021	We previously reported that priming of mesenchymal stromal cells (MSCs) with poly(I:C) induced them to express indoleamine 2,3-dioxygenase (IDO).	Poly I-C	77-86	indoleamine 2,3-dioxygenase 1	Mus musculus	140-143
33413597-3	2021	We tried to find out whether the IFN-gamma and poly(I:C)-primed MSCs have better therapeutic efficacy on the experimental colitis in the IDO1-dependent manner.	Poly I-C	47-56	indoleamine 2,3-dioxygenase 1	Mus musculus	137-141
33219146-4	2021	In this study, we show that NUDT21, an RNA-binding protein that regulates alternative transcript polyadenylation, physically associates with IPS-1 and mediates its localization to SGs in response to transfection with polyinosinic-polycytidylic acid [poly(I:C)], a mimic of viral dsRNA.	Poly I-C	217-248	nudix hydrolase 21	Homo sapiens	28-34
33401559-5	2021	Here, we investigated the involvement of mitochondrial dynamics and mitochondrial ribosome protein death-associated protein 3 (DAP3) in the modulation of cellular radiation response by Poly(I:C) in A549 and H1299 human lung adenocarcinoma cell lines.	Poly I-C	185-194	death associated protein 3	Homo sapiens	127-131
33401559-6	2021	Western blotting revealed that Poly(I:C) decreased the expression of mitochondrial dynamics-related proteins and DAP3.	Poly I-C	31-40	death associated protein 3	Homo sapiens	113-117
33401559-8	2021	Finally, we revealed that a more-than-additive effect of cotreatment with Poly(I:C) and IR on increasing cell death was diluted by DAP3-knockdown because of an increase in cell death induced by IR alone.	Poly I-C	74-83	death associated protein 3	Homo sapiens	131-135
33401559-9	2021	Together, our findings suggest that RLR agonist Poly(I:C) modulates the cellular radiation response of lung adenocarcinoma cells by downregulating DAP3 expression.	Poly I-C	48-57	death associated protein 3	Homo sapiens	147-151
32835835-6	2021	When stimulated with Streptococcus agalactiae, Aeromonas hydrophila, Poly(I:C), or LPS in vivo and in vitro, the expression of OnCXCR4 was significantly regulated.	Poly I-C	69-78	C-X-C chemokine receptor type 4	Oreochromis niloticus	127-134
33326977-5	2021	METHODS: Human GECs were cultured and stimulated with polyinosinic-polycytidylic acid (poly IC), a synthetic TLR3 agonist.	Poly I-C	54-85	toll like receptor 3	Homo sapiens	109-113
33326977-5	2021	METHODS: Human GECs were cultured and stimulated with polyinosinic-polycytidylic acid (poly IC), a synthetic TLR3 agonist.	Poly I-C	87-94	toll like receptor 3	Homo sapiens	109-113
33326977-12	2021	CONCLUSION: IFIT1/2/3 and CXCL10 were induced by poly IC via IFN-beta in GECs.	Poly I-C	49-56	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	12-21
33326977-12	2021	CONCLUSION: IFIT1/2/3 and CXCL10 were induced by poly IC via IFN-beta in GECs.	Poly I-C	49-56	C-X-C motif chemokine ligand 10	Homo sapiens	26-32
33326977-12	2021	CONCLUSION: IFIT1/2/3 and CXCL10 were induced by poly IC via IFN-beta in GECs.	Poly I-C	49-56	IFN1@	Homo sapiens	61-69
33383149-0	2021	IL-33 ameliorates liver injury and inflammation in Poly I:C and Concanavalin-A induced acute hepatitis.	Poly I-C	51-59	interleukin 33	Mus musculus	0-5
33383149-6	2021	The gross pathological liver injury induced by Poly I:C or ConA was reduced by rIL-33 administration in mice.	Poly I-C	47-55	interleukin 33	Rattus norvegicus	79-85
33383149-7	2021	The levels of AST and ALT were significantly (P <= 0.05) higher in mice challenged with Poly I:C or ConA in comparison to control mice.	Poly I-C	88-96	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	14-17
33383149-7	2021	The levels of AST and ALT were significantly (P <= 0.05) higher in mice challenged with Poly I:C or ConA in comparison to control mice.	Poly I-C	88-96	glutamic pyruvic transaminase, soluble	Mus musculus	22-25
33383149-11	2021	In conclusion, the exogenous IL-33 administration mitigated liver injury and inflammation (decreased levels of IFNgamma and TNFalpha) in Poly I:C and ConA-induced acute hepatitis in mice.	Poly I-C	137-145	interleukin 33	Mus musculus	29-34
33383149-11	2021	In conclusion, the exogenous IL-33 administration mitigated liver injury and inflammation (decreased levels of IFNgamma and TNFalpha) in Poly I:C and ConA-induced acute hepatitis in mice.	Poly I-C	137-145	interferon gamma	Mus musculus	111-119
33383149-11	2021	In conclusion, the exogenous IL-33 administration mitigated liver injury and inflammation (decreased levels of IFNgamma and TNFalpha) in Poly I:C and ConA-induced acute hepatitis in mice.	Poly I-C	137-145	tumor necrosis factor	Mus musculus	124-132
33310189-6	2021	In the MIA model of gestational polyinosinic-polycytidylic acid (poly(I:C)) exposure, increased serum levels of IL-6 were observed in both wild-type (WT) and Nox1-deficient mice (Nox1KO).	Poly I-C	32-63	interleukin 6	Mus musculus	112-116
33310189-6	2021	In the MIA model of gestational polyinosinic-polycytidylic acid (poly(I:C)) exposure, increased serum levels of IL-6 were observed in both wild-type (WT) and Nox1-deficient mice (Nox1KO).	Poly I-C	32-63	NADPH oxidase 1	Mus musculus	158-162
33310189-6	2021	In the MIA model of gestational polyinosinic-polycytidylic acid (poly(I:C)) exposure, increased serum levels of IL-6 were observed in both wild-type (WT) and Nox1-deficient mice (Nox1KO).	Poly I-C	32-63	NADPH oxidase 1	Mus musculus	179-185
33310189-6	2021	In the MIA model of gestational polyinosinic-polycytidylic acid (poly(I:C)) exposure, increased serum levels of IL-6 were observed in both wild-type (WT) and Nox1-deficient mice (Nox1KO).	Poly I-C	65-74	interleukin 6	Mus musculus	112-116
33310189-6	2021	In the MIA model of gestational polyinosinic-polycytidylic acid (poly(I:C)) exposure, increased serum levels of IL-6 were observed in both wild-type (WT) and Nox1-deficient mice (Nox1KO).	Poly I-C	65-74	NADPH oxidase 1	Mus musculus	158-162
33310189-6	2021	In the MIA model of gestational polyinosinic-polycytidylic acid (poly(I:C)) exposure, increased serum levels of IL-6 were observed in both wild-type (WT) and Nox1-deficient mice (Nox1KO).	Poly I-C	65-74	NADPH oxidase 1	Mus musculus	179-185
33402460-0	2021	PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes.	Poly I-C	0-6	DExD/H-box helicase 58	Homo sapiens	15-45
33402460-0	2021	PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes.	Poly I-C	0-6	interferon induced with helicase C domain 1	Homo sapiens	50-92
33402460-2	2021	We examined the effect of polyinosinic-polycytidylic acid (polyIC) on the expression of retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) in differentiated human podocytes in culture.	Poly I-C	26-57	DExD/H-box helicase 58	Homo sapiens	88-118
33402460-2	2021	We examined the effect of polyinosinic-polycytidylic acid (polyIC) on the expression of retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) in differentiated human podocytes in culture.	Poly I-C	26-57	DExD/H-box helicase 58	Homo sapiens	120-125
33402460-2	2021	We examined the effect of polyinosinic-polycytidylic acid (polyIC) on the expression of retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) in differentiated human podocytes in culture.	Poly I-C	26-57	interferon induced with helicase C domain 1	Homo sapiens	131-173
33402460-2	2021	We examined the effect of polyinosinic-polycytidylic acid (polyIC) on the expression of retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) in differentiated human podocytes in culture.	Poly I-C	26-57	interferon induced with helicase C domain 1	Homo sapiens	175-179
33402460-2	2021	We examined the effect of polyinosinic-polycytidylic acid (polyIC) on the expression of retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) in differentiated human podocytes in culture.	Poly I-C	59-65	DExD/H-box helicase 58	Homo sapiens	88-118
33402460-2	2021	We examined the effect of polyinosinic-polycytidylic acid (polyIC) on the expression of retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) in differentiated human podocytes in culture.	Poly I-C	59-65	DExD/H-box helicase 58	Homo sapiens	120-125
33402460-2	2021	We examined the effect of polyinosinic-polycytidylic acid (polyIC) on the expression of retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) in differentiated human podocytes in culture.	Poly I-C	59-65	interferon induced with helicase C domain 1	Homo sapiens	131-173
33402460-2	2021	We examined the effect of polyinosinic-polycytidylic acid (polyIC) on the expression of retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) in differentiated human podocytes in culture.	Poly I-C	59-65	interferon induced with helicase C domain 1	Homo sapiens	175-179
33827102-4	2021	To further elucidate the poly IC-induced signaling pathway, we subjected the cells to RNA interference against IFN-beta and IL-6.	Poly I-C	25-32	IFN1@	Homo sapiens	111-119
33827102-4	2021	To further elucidate the poly IC-induced signaling pathway, we subjected the cells to RNA interference against IFN-beta and IL-6.	Poly I-C	25-32	interleukin 6	Homo sapiens	124-128
33219146-4	2021	In this study, we show that NUDT21, an RNA-binding protein that regulates alternative transcript polyadenylation, physically associates with IPS-1 and mediates its localization to SGs in response to transfection with polyinosinic-polycytidylic acid [poly(I:C)], a mimic of viral dsRNA.	Poly I-C	217-248	RNA binding motif single stranded interacting protein 3	Homo sapiens	39-58
33219146-4	2021	In this study, we show that NUDT21, an RNA-binding protein that regulates alternative transcript polyadenylation, physically associates with IPS-1 and mediates its localization to SGs in response to transfection with polyinosinic-polycytidylic acid [poly(I:C)], a mimic of viral dsRNA.	Poly I-C	217-248	mitochondrial antiviral signaling protein	Homo sapiens	141-146
33219146-4	2021	In this study, we show that NUDT21, an RNA-binding protein that regulates alternative transcript polyadenylation, physically associates with IPS-1 and mediates its localization to SGs in response to transfection with polyinosinic-polycytidylic acid [poly(I:C)], a mimic of viral dsRNA.	Poly I-C	250-259	nudix hydrolase 21	Homo sapiens	28-34
33219146-4	2021	In this study, we show that NUDT21, an RNA-binding protein that regulates alternative transcript polyadenylation, physically associates with IPS-1 and mediates its localization to SGs in response to transfection with polyinosinic-polycytidylic acid [poly(I:C)], a mimic of viral dsRNA.	Poly I-C	250-259	RNA binding motif single stranded interacting protein 3	Homo sapiens	39-58
33219146-4	2021	In this study, we show that NUDT21, an RNA-binding protein that regulates alternative transcript polyadenylation, physically associates with IPS-1 and mediates its localization to SGs in response to transfection with polyinosinic-polycytidylic acid [poly(I:C)], a mimic of viral dsRNA.	Poly I-C	250-259	mitochondrial antiviral signaling protein	Homo sapiens	141-146
33260038-3	2021	Herein, we found that tryptanthrin suppressed the expression of CXCL10 in HUVEC upon stimulation with a TLR3 ligand polyinosinic-polycytidylic acid (poly IC).	Poly I-C	116-147	C-X-C motif chemokine ligand 10	Homo sapiens	64-70
33219146-5	2021	We found that despite its well-established function in the nucleus, a fraction of NUDT21 localizes to mitochondria in resting cells and becomes localized to SGs in response to poly(I:C) transfection.	Poly I-C	176-185	nudix hydrolase 21	Homo sapiens	82-88
33260038-3	2021	Herein, we found that tryptanthrin suppressed the expression of CXCL10 in HUVEC upon stimulation with a TLR3 ligand polyinosinic-polycytidylic acid (poly IC).	Poly I-C	116-147	toll like receptor 3	Homo sapiens	104-108
33260038-3	2021	Herein, we found that tryptanthrin suppressed the expression of CXCL10 in HUVEC upon stimulation with a TLR3 ligand polyinosinic-polycytidylic acid (poly IC).	Poly I-C	149-156	C-X-C motif chemokine ligand 10	Homo sapiens	64-70
33372174-5	2020	In addition, the SARS-CoV-2 M protein suppresses type I and III IFN induction stimulated by SeV infection or poly (I:C) transfection.	Poly I-C	109-119	membrane glycoprotein	Severe acute respiratory syndrome coronavirus 2	28-29
33260038-3	2021	Herein, we found that tryptanthrin suppressed the expression of CXCL10 in HUVEC upon stimulation with a TLR3 ligand polyinosinic-polycytidylic acid (poly IC).	Poly I-C	149-156	toll like receptor 3	Homo sapiens	104-108
33191000-6	2021	After challenge with poly(I:C), a synthetic analogue of dsRNA used to stimulate IFN-beta secretion in the TLR-controlled pathway, we show that PHEV and poly(I:C) regulate IFN-beta-induction via two different pathways.	Poly I-C	21-30	IFN1@	Homo sapiens	80-88
33191000-6	2021	After challenge with poly(I:C), a synthetic analogue of dsRNA used to stimulate IFN-beta secretion in the TLR-controlled pathway, we show that PHEV and poly(I:C) regulate IFN-beta-induction via two different pathways.	Poly I-C	21-30	IFN1@	Homo sapiens	171-179
33191000-6	2021	After challenge with poly(I:C), a synthetic analogue of dsRNA used to stimulate IFN-beta secretion in the TLR-controlled pathway, we show that PHEV and poly(I:C) regulate IFN-beta-induction via two different pathways.	Poly I-C	152-161	IFN1@	Homo sapiens	80-88
33191000-6	2021	After challenge with poly(I:C), a synthetic analogue of dsRNA used to stimulate IFN-beta secretion in the TLR-controlled pathway, we show that PHEV and poly(I:C) regulate IFN-beta-induction via two different pathways.	Poly I-C	152-161	IFN1@	Homo sapiens	171-179
33396605-4	2020	N protein repressed IFN-beta production induced by poly(I:C) or upon Sendai virus (SeV) infection.	Poly I-C	51-60	IFN1@	Homo sapiens	20-28
33372174-5	2020	In addition, the SARS-CoV-2 M protein suppresses type I and III IFN induction stimulated by SeV infection or poly (I:C) transfection.	Poly I-C	109-119	type i and iii ifn	None	49-67
33298177-6	2020	Overexpression of chicken TRIM25 in DF1 cells dramatically decreased the antigenic titres of ALV-A in the cell supernatant and upregulated the relative expression of MDA5, MAVS and IFN-beta induced by ALV-A or by poly(I:C); in contrast, knockdown of chicken TRIM25 significantly increased the antigenic titres of ALV-A and downregulated the relative expression of MDA5, MAVS and IFN-beta.	Poly I-C	213-222	tripartite motif containing 25	Gallus gallus	26-32
33046245-4	2020	RESULT: Dopaminergic neurons in the nigra and striatum were markedly reduced in WT mice after administration of poly I:C together with abundant microglial activation in the SN, and the expression of alpha-synuclein was also elevated.	Poly I-C	112-120	synuclein, alpha	Mus musculus	199-214
33332692-5	2021	METHODS: Cultured normal human GECs were treated with polyinosinic-polycytidylic acid (poly IC), a synthesized viral double-stranded RNA, then the expression of IFITM1 was examined by quantitative real-time reverse transcription-polymerase chain reaction and western blotting.	Poly I-C	54-85	interferon induced transmembrane protein 1	Homo sapiens	161-167
33332692-5	2021	METHODS: Cultured normal human GECs were treated with polyinosinic-polycytidylic acid (poly IC), a synthesized viral double-stranded RNA, then the expression of IFITM1 was examined by quantitative real-time reverse transcription-polymerase chain reaction and western blotting.	Poly I-C	87-94	interferon induced transmembrane protein 1	Homo sapiens	161-167
33332692-6	2021	To further elucidate the poly IC-induced signaling pathway, the cells were applied to RNA interference against IFN-beta, nuclear factor (NF)-kappaB p65, and IFN regulatory factor (IRF) 3.	Poly I-C	25-32	IFN1@	Homo sapiens	111-119
33332692-6	2021	To further elucidate the poly IC-induced signaling pathway, the cells were applied to RNA interference against IFN-beta, nuclear factor (NF)-kappaB p65, and IFN regulatory factor (IRF) 3.	Poly I-C	25-32	RELA proto-oncogene, NF-kB subunit	Homo sapiens	121-151
33332692-6	2021	To further elucidate the poly IC-induced signaling pathway, the cells were applied to RNA interference against IFN-beta, nuclear factor (NF)-kappaB p65, and IFN regulatory factor (IRF) 3.	Poly I-C	25-32	interferon regulatory factor 3	Homo sapiens	157-186
33381112-11	2020	Epithelial cells express PKD3, and PKD3 siRNA knock-down inhibited polyI:C induced cytokine production.	Poly I-C	67-74	PKD3	Homo sapiens	25-29
33381112-11	2020	Epithelial cells express PKD3, and PKD3 siRNA knock-down inhibited polyI:C induced cytokine production.	Poly I-C	67-74	PKD3	Homo sapiens	35-39
33381112-12	2020	Lung epithelial-specific deletion of PKD3 (CC10-Cre x PKD3-floxed mice) partially attenuated polyI:C-induced barrier disruption in vivo.	Poly I-C	93-100	protein kinase D3	Mus musculus	37-41
33316896-5	2020	In human keratinocytes, UBAC1 negatively regulates the NF-kappaF-activating capacity of CARMA2sh following exposure to poly (I:C), an agonist of Toll-like Receptor 3.	Poly I-C	119-129	UBA domain containing 1	Homo sapiens	24-29
33316896-5	2020	In human keratinocytes, UBAC1 negatively regulates the NF-kappaF-activating capacity of CARMA2sh following exposure to poly (I:C), an agonist of Toll-like Receptor 3.	Poly I-C	119-129	caspase recruitment domain family member 14	Homo sapiens	88-94
33316896-5	2020	In human keratinocytes, UBAC1 negatively regulates the NF-kappaF-activating capacity of CARMA2sh following exposure to poly (I:C), an agonist of Toll-like Receptor 3.	Poly I-C	119-129	toll like receptor 3	Homo sapiens	145-165
33352813-6	2020	Ectopic expression of FPV184 inhibited polyI:C activation of the chicken IFN-beta promoter and IFN-alpha activation of the chicken Mx1 promoter.	Poly I-C	39-46	hypothetical protein	Fowlpox virus	22-28
33352813-6	2020	Ectopic expression of FPV184 inhibited polyI:C activation of the chicken IFN-beta promoter and IFN-alpha activation of the chicken Mx1 promoter.	Poly I-C	39-46	interferon	Gallus gallus	73-81
33087322-8	2020	The MDA5/LGP2 agonist high molecular weight poly I: C improved the anti-tumor effect of IR.	Poly I-C	44-53	interferon induced with helicase C domain 1	Homo sapiens	4-8
33087322-8	2020	The MDA5/LGP2 agonist high molecular weight poly I: C improved the anti-tumor effect of IR.	Poly I-C	44-53	DExH-box helicase 58	Homo sapiens	9-13
33035644-6	2020	Expression of IFIT5 was significantly up-regulated following Newcastle disease virus (NDV)-, polyinosinic:polycytidylic acid [poly (I:C)]-, and poly(deoxyadenylic-thymidylic)[poly (dA:dT)]-triggered antiviral immune response.	Poly I-C	126-136	interferon induced protein with tetratricopeptide repeats 5	Homo sapiens	14-19
33308248-11	2020	Adult wmASTRs and gmASTRs responding to TLR3 agonist Poly(I:C) distinctly modulate OPC behavior, while exposure to TLR4 agonist LPS of both gmASTRs and wmASTRs results in a prominent decrease in myelin membrane formation.	Poly I-C	53-62	toll like receptor 3	Homo sapiens	40-44
33911791-9	2020	When keratinocytes were stimulated with TLR3 agonist poly(I:C), KDM2A was increased at both the mRNA and protein levels.	Poly I-C	53-62	toll like receptor 3	Homo sapiens	40-44
33911791-9	2020	When keratinocytes were stimulated with TLR3 agonist poly(I:C), KDM2A was increased at both the mRNA and protein levels.	Poly I-C	53-62	lysine demethylase 2A	Homo sapiens	64-69
33911791-10	2020	Poly(I:C) increased the expression of psoriasis-related cytokines including tumor necrosis factor-alpha, interleukin-8, and CCL20, and KDM2A inhibitor daminozide enhanced the poly(I:C)-induced cytokine expression.	Poly I-C	0-9	tumor necrosis factor	Homo sapiens	76-103
33911791-10	2020	Poly(I:C) increased the expression of psoriasis-related cytokines including tumor necrosis factor-alpha, interleukin-8, and CCL20, and KDM2A inhibitor daminozide enhanced the poly(I:C)-induced cytokine expression.	Poly I-C	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	105-118
33911791-10	2020	Poly(I:C) increased the expression of psoriasis-related cytokines including tumor necrosis factor-alpha, interleukin-8, and CCL20, and KDM2A inhibitor daminozide enhanced the poly(I:C)-induced cytokine expression.	Poly I-C	0-9	C-C motif chemokine ligand 20	Homo sapiens	124-129
33911791-10	2020	Poly(I:C) increased the expression of psoriasis-related cytokines including tumor necrosis factor-alpha, interleukin-8, and CCL20, and KDM2A inhibitor daminozide enhanced the poly(I:C)-induced cytokine expression.	Poly I-C	175-184	lysine demethylase 2A	Homo sapiens	135-140
32578219-7	2020	Exposure of PBECs to concomitant TLR3 agonist poly(I:C) and HDM resulted in a significant reduction in epithelial cell proliferation in PSW compared to controls.	Poly I-C	46-55	toll like receptor 3	Homo sapiens	33-37
33011435-9	2020	LcIRF1, LcIRF3, LcIRF7, LcIRF8, and LcIRF10 were more strongly induced by poly (I:C) than the other LcIRFs.	Poly I-C	74-84	interferon regulatory factor 1	Larimichthys crocea	0-6
33011435-9	2020	LcIRF1, LcIRF3, LcIRF7, LcIRF8, and LcIRF10 were more strongly induced by poly (I:C) than the other LcIRFs.	Poly I-C	74-84	interferon regulatory factor 3	Larimichthys crocea	8-14
33011435-9	2020	LcIRF1, LcIRF3, LcIRF7, LcIRF8, and LcIRF10 were more strongly induced by poly (I:C) than the other LcIRFs.	Poly I-C	74-84	interferon regulatory factor 7	Larimichthys crocea	16-22
33011435-9	2020	LcIRF1, LcIRF3, LcIRF7, LcIRF8, and LcIRF10 were more strongly induced by poly (I:C) than the other LcIRFs.	Poly I-C	74-84	interferon regulatory factor 8	Larimichthys crocea	24-30
32554054-6	2020	The intranasal immunization of BALB/c mice with MVs plus a TLR3 agonist, poly(I-C), was performed 2 or 3 times for 5 weeks, with an interval of 2 or 3 weeks.	Poly I-C	73-82	toll-like receptor 3	Mus musculus	59-63
33174050-7	2020	Immunofluorescence analysis revealed that SFN attenuated the production of poly(I:C)-induced nuclear translocation of the NF-kappaB p65 subunit.	Poly I-C	75-84	RELA proto-oncogene, NF-kB subunit	Homo sapiens	122-135
33174050-8	2020	Reverse transcription-quantitative PCR analysis revealed that SFN prevented the poly(I:C)-induced upregulation of Toll-like receptor 3 (TLR3) mRNA expression in HCFs.	Poly I-C	80-89	toll like receptor 3	Homo sapiens	114-134
33174050-8	2020	Reverse transcription-quantitative PCR analysis revealed that SFN prevented the poly(I:C)-induced upregulation of Toll-like receptor 3 (TLR3) mRNA expression in HCFs.	Poly I-C	80-89	toll like receptor 3	Homo sapiens	136-140
33174050-10	2020	In summary, SFN attenuated the poly(I:C)-induced production of proinflammatory chemokines, cytokines and MMPs by HCFs, by inhibiting TLR3, MAPK (p38 and ERK), AP-1, Akt and NF-kappaB signaling.	Poly I-C	31-40	toll like receptor 3	Homo sapiens	133-137
33174050-10	2020	In summary, SFN attenuated the poly(I:C)-induced production of proinflammatory chemokines, cytokines and MMPs by HCFs, by inhibiting TLR3, MAPK (p38 and ERK), AP-1, Akt and NF-kappaB signaling.	Poly I-C	31-40	mitogen-activated protein kinase 1	Homo sapiens	145-148
33174050-10	2020	In summary, SFN attenuated the poly(I:C)-induced production of proinflammatory chemokines, cytokines and MMPs by HCFs, by inhibiting TLR3, MAPK (p38 and ERK), AP-1, Akt and NF-kappaB signaling.	Poly I-C	31-40	mitogen-activated protein kinase 1	Homo sapiens	153-156
33174050-10	2020	In summary, SFN attenuated the poly(I:C)-induced production of proinflammatory chemokines, cytokines and MMPs by HCFs, by inhibiting TLR3, MAPK (p38 and ERK), AP-1, Akt and NF-kappaB signaling.	Poly I-C	31-40	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	159-163
33174050-10	2020	In summary, SFN attenuated the poly(I:C)-induced production of proinflammatory chemokines, cytokines and MMPs by HCFs, by inhibiting TLR3, MAPK (p38 and ERK), AP-1, Akt and NF-kappaB signaling.	Poly I-C	31-40	AKT serine/threonine kinase 1	Homo sapiens	165-168
33174050-5	2020	ELISA showed that SFN was associated with a time- and dose-dependent reduction in poly(I:C)-stimulated production of interleukin (IL)-8, chemoattractant protein-1, IL-6, MMP-1 and MMP-3 by HCFs.	Poly I-C	82-91	C-X-C motif chemokine ligand 8	Homo sapiens	117-135
33174050-5	2020	ELISA showed that SFN was associated with a time- and dose-dependent reduction in poly(I:C)-stimulated production of interleukin (IL)-8, chemoattractant protein-1, IL-6, MMP-1 and MMP-3 by HCFs.	Poly I-C	82-91	interleukin 6	Homo sapiens	164-168
33174050-5	2020	ELISA showed that SFN was associated with a time- and dose-dependent reduction in poly(I:C)-stimulated production of interleukin (IL)-8, chemoattractant protein-1, IL-6, MMP-1 and MMP-3 by HCFs.	Poly I-C	82-91	matrix metallopeptidase 3	Homo sapiens	180-185
33176874-6	2020	Moreover, pUL47 significantly inhibited polyriboinosinic:polyribocytidylic acid [poly(I:C)]-induced interferon beta (IFN-beta) production and downregulated interferon-stimulated gene (ISG) expression, such as Mx and oligoadenylate synthetase-like (OASL), by interacting with signal transducer and activator of transcription-1 (STAT1).	Poly I-C	81-90	interferon beta 1	Homo sapiens	100-115
32929473-5	2020	Upon Mx1-Cre activation in hematopoietic cells induced by poly (I:C) injection, all Mx1-CreCbfb+/56Mmice developed leukemia in 5 months while no leukemia developed in Runx1f/fMx1-CreCbfb+/56Mmice, and this effect was cell autonomous.	Poly I-C	58-68	MX dynamin-like GTPase 1	Mus musculus	5-8
32929473-5	2020	Upon Mx1-Cre activation in hematopoietic cells induced by poly (I:C) injection, all Mx1-CreCbfb+/56Mmice developed leukemia in 5 months while no leukemia developed in Runx1f/fMx1-CreCbfb+/56Mmice, and this effect was cell autonomous.	Poly I-C	58-68	MX dynamin-like GTPase 1	Mus musculus	84-87
33248566-5	2020	The direct poly(I:C) treatment significantly increased IFN-beta and IL-8 gene expression along with the cytoplasmic dsRNA receptor, melanoma differentiation-associated gene 5 (MDA5), in WT cells, whereas no changes in all corresponding genes were observed in KO cells.	Poly I-C	11-20	interferon induced with helicase C domain 1	Homo sapiens	176-180
33248566-6	2020	We further confirmed the antiviral effects of poly(I:C)-induced TLR3-mediated immunity by demonstrating significant reduction of virus titer in poly(I:C)-treated WT cells, but not in TLR3 KO cells.	Poly I-C	46-55	toll like receptor 3	Homo sapiens	64-68
33248566-6	2020	We further confirmed the antiviral effects of poly(I:C)-induced TLR3-mediated immunity by demonstrating significant reduction of virus titer in poly(I:C)-treated WT cells, but not in TLR3 KO cells.	Poly I-C	144-153	toll like receptor 3	Homo sapiens	64-68
33281554-5	2020	TLR3 was transported rapidly to early EEA1-positive endosomes as well as LAMP1-lysosomes following stimulation with the poly(I:C).	Poly I-C	120-129	toll-like receptor 3	Mus musculus	0-4
33281554-5	2020	TLR3 was transported rapidly to early EEA1-positive endosomes as well as LAMP1-lysosomes following stimulation with the poly(I:C).	Poly I-C	120-129	early endosome antigen 1	Mus musculus	38-42
33281554-5	2020	TLR3 was transported rapidly to early EEA1-positive endosomes as well as LAMP1-lysosomes following stimulation with the poly(I:C).	Poly I-C	120-129	lysosomal-associated membrane protein 1	Mus musculus	73-78
33281554-8	2020	TLR3 interacted with poly(I:C) intracellularly from 1 min to 8 h following cell stimulation.	Poly I-C	21-30	toll-like receptor 3	Mus musculus	0-4
33281554-9	2020	We detected TLR3 on the surface of astrocytes indicating constitutive expression, which increased after poly(I:C) stimulation.	Poly I-C	104-113	toll-like receptor 3	Mus musculus	12-16
33198300-9	2020	Treatment of PAMs with cell culture supernatants from macrophages subjected to NLRP3 inflammasome activation (via polyinosinic-polycytidylic acid (poly I:C) transfection), prior to PRRSV infection resulted in significantly reduced viral RNA levels compared to PAMs treated with cell culture supernatants from macrophages subjected to NLRP3 inflammasome inhibition (MCC950 treatment/poly I:C transfection).	Poly I-C	114-145	NLR family pyrin domain containing 3	Homo sapiens	79-84
33176874-6	2020	Moreover, pUL47 significantly inhibited polyriboinosinic:polyribocytidylic acid [poly(I:C)]-induced interferon beta (IFN-beta) production and downregulated interferon-stimulated gene (ISG) expression, such as Mx and oligoadenylate synthetase-like (OASL), by interacting with signal transducer and activator of transcription-1 (STAT1).	Poly I-C	81-90	IFN1@	Homo sapiens	117-125
32967931-4	2020	Importantly, we show that IgG immune complexes strongly potentiate activation of primary human microglia by breaking their tolerance for microbial stimuli, such as LPS and Poly I:C, resulting in increased production of key proinflammatory cytokines, such as TNF and IL-1beta.	Poly I-C	172-180	tumor necrosis factor	Homo sapiens	258-261
33154351-0	2020	Poly(I:C) preconditioning protects the heart against myocardial ischemia/reperfusion injury through TLR3/PI3K/Akt-dependent pathway.	Poly I-C	0-9	toll like receptor 3	Homo sapiens	100-104
33154351-0	2020	Poly(I:C) preconditioning protects the heart against myocardial ischemia/reperfusion injury through TLR3/PI3K/Akt-dependent pathway.	Poly I-C	0-9	AKT serine/threonine kinase 1	Homo sapiens	110-113
33154351-2	2020	As the ligand of TLR3, polyinosinic-polycytidylic acid (poly(I:C)), a synthetic double-stranded RNA, whether its preconditioning can exhibit a cardioprotective phenotype remains unknown.	Poly I-C	23-54	toll like receptor 3	Homo sapiens	17-21
33154351-2	2020	As the ligand of TLR3, polyinosinic-polycytidylic acid (poly(I:C)), a synthetic double-stranded RNA, whether its preconditioning can exhibit a cardioprotective phenotype remains unknown.	Poly I-C	56-65	toll like receptor 3	Homo sapiens	17-21
33154351-3	2020	Here, we report the protective effect of poly(I:C) pretreatment in acute myocardial I/R injury by activating TLR3/PI3K/Akt signaling pathway.	Poly I-C	41-50	toll like receptor 3	Homo sapiens	109-113
33154351-3	2020	Here, we report the protective effect of poly(I:C) pretreatment in acute myocardial I/R injury by activating TLR3/PI3K/Akt signaling pathway.	Poly I-C	41-50	AKT serine/threonine kinase 1	Homo sapiens	119-122
33154351-5	2020	Subsequently, our data demonstrate that phosphorylation of TLR3 tyrosine residue and its interaction with PI3K is enhanced, and protein levels of phospho-PI3K and phospho-Akt are both increased after poly(I:C) pretreatment, while knock out of TLR3 suppresses the cardioprotection of poly(I:C) preconditioning through a decreased activation of PI3K/Akt signaling.	Poly I-C	200-209	toll like receptor 3	Homo sapiens	59-63
33154351-5	2020	Subsequently, our data demonstrate that phosphorylation of TLR3 tyrosine residue and its interaction with PI3K is enhanced, and protein levels of phospho-PI3K and phospho-Akt are both increased after poly(I:C) pretreatment, while knock out of TLR3 suppresses the cardioprotection of poly(I:C) preconditioning through a decreased activation of PI3K/Akt signaling.	Poly I-C	200-209	AKT serine/threonine kinase 1	Homo sapiens	171-174
33154351-5	2020	Subsequently, our data demonstrate that phosphorylation of TLR3 tyrosine residue and its interaction with PI3K is enhanced, and protein levels of phospho-PI3K and phospho-Akt are both increased after poly(I:C) pretreatment, while knock out of TLR3 suppresses the cardioprotection of poly(I:C) preconditioning through a decreased activation of PI3K/Akt signaling.	Poly I-C	200-209	toll like receptor 3	Homo sapiens	243-247
33154351-5	2020	Subsequently, our data demonstrate that phosphorylation of TLR3 tyrosine residue and its interaction with PI3K is enhanced, and protein levels of phospho-PI3K and phospho-Akt are both increased after poly(I:C) pretreatment, while knock out of TLR3 suppresses the cardioprotection of poly(I:C) preconditioning through a decreased activation of PI3K/Akt signaling.	Poly I-C	200-209	AKT serine/threonine kinase 1	Homo sapiens	348-351
33154351-5	2020	Subsequently, our data demonstrate that phosphorylation of TLR3 tyrosine residue and its interaction with PI3K is enhanced, and protein levels of phospho-PI3K and phospho-Akt are both increased after poly(I:C) pretreatment, while knock out of TLR3 suppresses the cardioprotection of poly(I:C) preconditioning through a decreased activation of PI3K/Akt signaling.	Poly I-C	283-292	toll like receptor 3	Homo sapiens	59-63
33154351-5	2020	Subsequently, our data demonstrate that phosphorylation of TLR3 tyrosine residue and its interaction with PI3K is enhanced, and protein levels of phospho-PI3K and phospho-Akt are both increased after poly(I:C) pretreatment, while knock out of TLR3 suppresses the cardioprotection of poly(I:C) preconditioning through a decreased activation of PI3K/Akt signaling.	Poly I-C	283-292	AKT serine/threonine kinase 1	Homo sapiens	171-174
33154351-6	2020	Moreover, inhibition of p85 PI3K by the administration of LY294002 in vivo and knockdown of Akt by siRNA in vitro significantly abolish poly(I:C) preconditioning-induced cardioprotective effect.	Poly I-C	136-145	AKT serine/threonine kinase 1	Homo sapiens	92-95
33154351-7	2020	In conclusion, our results reveal that poly(I:C) preconditioning exhibits essential protection in myocardial I/R injury via its modulation of TLR3, and the downstream PI3K/Akt signaling, which may provide a potential pharmacologic target for perioperative cardioprotection.	Poly I-C	39-48	toll like receptor 3	Homo sapiens	142-146
33154351-7	2020	In conclusion, our results reveal that poly(I:C) preconditioning exhibits essential protection in myocardial I/R injury via its modulation of TLR3, and the downstream PI3K/Akt signaling, which may provide a potential pharmacologic target for perioperative cardioprotection.	Poly I-C	39-48	AKT serine/threonine kinase 1	Homo sapiens	172-175
33087577-5	2020	We found that CDNs containing adenosine induced a robust CFTR-mediated chloride secretory response together with cAMP-mediated inhibition of Poly I:C-stimulated IFNbeta expression.	Poly I-C	141-149	IFN1@	Homo sapiens	161-168
32935490-11	2020	IL-22Ra1 was up-regulated with poly(I:C) stimulation in NHBE cells.	Poly I-C	31-40	interleukin 22 receptor subunit alpha 1	Homo sapiens	0-8
33058425-3	2020	By administering intranasal Poly (I:C), a synthetic viral dsRNA, while we were able to mimic the symptoms of ARDS in a murine model, interestingly, there was a significant decrease in the expression of apelin in both blood and lung tissues.	Poly I-C	28-38	apelin	Mus musculus	202-208
33240904-5	2020	with the viral mimic and Toll-like receptor 3 (TLR3) ligand poly (I:C) after the last exposure.	Poly I-C	60-70	toll-like receptor 3	Mus musculus	25-45
33240904-5	2020	with the viral mimic and Toll-like receptor 3 (TLR3) ligand poly (I:C) after the last exposure.	Poly I-C	60-70	toll-like receptor 3	Mus musculus	47-51
33240904-12	2020	Additional poly (I:C) challenge further increased the population of inflammatory DCs and conventional DCs, especially CD11b+ cDCs.	Poly I-C	11-21	integrin subunit alpha M	Homo sapiens	118-123
32898511-9	2020	LPS, Poly I:C and TNFalpha significantly induce the secretion of IL-6 and IL-8 at all tested time points.	Poly I-C	5-13	interleukin 6	Homo sapiens	65-69
32898511-9	2020	LPS, Poly I:C and TNFalpha significantly induce the secretion of IL-6 and IL-8 at all tested time points.	Poly I-C	5-13	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
31625434-8	2020	Results: We found that poly IC-induced Fkn expression in GECs, and that this involved NF-kappaB, IFN-beta, and IRF3.	Poly I-C	23-30	nuclear factor kappa B subunit 1	Homo sapiens	86-95
31625434-8	2020	Results: We found that poly IC-induced Fkn expression in GECs, and that this involved NF-kappaB, IFN-beta, and IRF3.	Poly I-C	23-30	interferon beta 1	Homo sapiens	97-105
31625434-8	2020	Results: We found that poly IC-induced Fkn expression in GECs, and that this involved NF-kappaB, IFN-beta, and IRF3.	Poly I-C	23-30	interferon regulatory factor 3	Homo sapiens	111-115
33050324-7	2020	Furthermore, activation of IRF3 by polyinosinic-polycytidylic acid (poly I:C) produced a cooperative effect with TNF-alpha for MIP-1alpha/CCL3 production that was comparable to stearic acid.	Poly I-C	35-66	interferon regulatory factor 3	Homo sapiens	27-31
33121290-7	2021	NOB potentially induced TLR3/IRF3 signaling pathway and the activation of TLR3/IRF3 signaling pathway by both NOB and Poly I:C was more profound in LNCaP than PC-3 cells.	Poly I-C	118-126	toll like receptor 3	Homo sapiens	74-78
33121290-7	2021	NOB potentially induced TLR3/IRF3 signaling pathway and the activation of TLR3/IRF3 signaling pathway by both NOB and Poly I:C was more profound in LNCaP than PC-3 cells.	Poly I-C	118-126	interferon regulatory factor 3	Homo sapiens	79-83
33144864-12	2020	Namely, similar to BM-MSCs, SV-MSCs secreted increased amount of IL-6 and IL-8 after 12- or 24-hour treatment with LPS, PolyI:C, TNFalpha, or IL-1beta, compared to untreated controls.	Poly I-C	120-127	interleukin 6	Homo sapiens	65-69
33144864-12	2020	Namely, similar to BM-MSCs, SV-MSCs secreted increased amount of IL-6 and IL-8 after 12- or 24-hour treatment with LPS, PolyI:C, TNFalpha, or IL-1beta, compared to untreated controls.	Poly I-C	120-127	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
33086712-4	2020	We demonstrated that polyinosinic:polycytidylic acid (poly (I:C)) stimulation and viral infection (vesicular stomatitis (VSV) or porcine reproductive and respiratory syndrome virus (PRRSV)) induce expression of porTRIM26, whereas knock-down expression of porTRIM26 promotes interferon (IFN)- production after poly (I:C) stimulation and virus infection (VSV or PRRSV).	Poly I-C	54-64	interferon alpha 1	Homo sapiens	274-290
33066561-6	2020	After poly(I:C) treatment, AvBD2, 11, 12, 13, CATHB1 and LEAP2 increased in both cell types; CATH2 only increased in BMCs; and AvBD3, 6, 9, 14, CATH1, CATH3, and GNLY only increased in CEFs.	Poly I-C	6-15	defensin beta 4A	Gallus gallus	27-32
33066561-6	2020	After poly(I:C) treatment, AvBD2, 11, 12, 13, CATHB1 and LEAP2 increased in both cell types; CATH2 only increased in BMCs; and AvBD3, 6, 9, 14, CATH1, CATH3, and GNLY only increased in CEFs.	Poly I-C	6-15	cathelicidin B1	Gallus gallus	46-52
33066561-6	2020	After poly(I:C) treatment, AvBD2, 11, 12, 13, CATHB1 and LEAP2 increased in both cell types; CATH2 only increased in BMCs; and AvBD3, 6, 9, 14, CATH1, CATH3, and GNLY only increased in CEFs.	Poly I-C	6-15	liver enriched antimicrobial peptide 2	Gallus gallus	57-62
33066561-6	2020	After poly(I:C) treatment, AvBD2, 11, 12, 13, CATHB1 and LEAP2 increased in both cell types; CATH2 only increased in BMCs; and AvBD3, 6, 9, 14, CATH1, CATH3, and GNLY only increased in CEFs.	Poly I-C	6-15	avian beta-defensin 3	Gallus gallus	127-132
33066561-6	2020	After poly(I:C) treatment, AvBD2, 11, 12, 13, CATHB1 and LEAP2 increased in both cell types; CATH2 only increased in BMCs; and AvBD3, 6, 9, 14, CATH1, CATH3, and GNLY only increased in CEFs.	Poly I-C	6-15	cathelicidin-1	Gallus gallus	144-149
33066561-6	2020	After poly(I:C) treatment, AvBD2, 11, 12, 13, CATHB1 and LEAP2 increased in both cell types; CATH2 only increased in BMCs; and AvBD3, 6, 9, 14, CATH1, CATH3, and GNLY only increased in CEFs.	Poly I-C	6-15	cathelicidin-3	Gallus gallus	151-156
33066561-6	2020	After poly(I:C) treatment, AvBD2, 11, 12, 13, CATHB1 and LEAP2 increased in both cell types; CATH2 only increased in BMCs; and AvBD3, 6, 9, 14, CATH1, CATH3, and GNLY only increased in CEFs.	Poly I-C	6-15	granulysin	Gallus gallus	162-166
33036630-11	2020	In addition, RIPK1 was required for Poly(I:C) and Smac mimetic-induced apoptosis and necroptosis.	Poly I-C	36-45	receptor interacting serine/threonine kinase 1	Homo sapiens	13-18
33036630-13	2020	In vitro invasion demonstrated that Poly(I:C)-induced invasion through NF-kappaB and MAPK signaling.	Poly I-C	36-45	nuclear factor kappa B subunit 1	Homo sapiens	71-80
33036630-14	2020	Furthermore, the loss of RIPK1 enhanced Poly(I:C)-induced invasion and ERK activation in vitro.	Poly I-C	40-49	receptor interacting serine/threonine kinase 1	Homo sapiens	25-30
33036630-15	2020	Smac mimetic also reversed Poly(I:C)-induced invasion, partly mediated by RIPK1.	Poly I-C	27-36	receptor interacting serine/threonine kinase 1	Homo sapiens	74-79
33036630-17	2020	CONCLUSION: RIPK1 plays a pivotal role in TLR3 ligand, Poly(I:C)-induced cell death when cIAPs activity was inhibited and loss of RIPK1 enhanced Poly(I:C)-induced invasion which was partially reversed by Smac mimetic.	Poly I-C	55-64	receptor interacting serine/threonine kinase 1	Homo sapiens	12-17
33036630-17	2020	CONCLUSION: RIPK1 plays a pivotal role in TLR3 ligand, Poly(I:C)-induced cell death when cIAPs activity was inhibited and loss of RIPK1 enhanced Poly(I:C)-induced invasion which was partially reversed by Smac mimetic.	Poly I-C	55-64	toll like receptor 3	Homo sapiens	42-46
33036630-17	2020	CONCLUSION: RIPK1 plays a pivotal role in TLR3 ligand, Poly(I:C)-induced cell death when cIAPs activity was inhibited and loss of RIPK1 enhanced Poly(I:C)-induced invasion which was partially reversed by Smac mimetic.	Poly I-C	145-154	receptor interacting serine/threonine kinase 1	Homo sapiens	12-17
33036630-17	2020	CONCLUSION: RIPK1 plays a pivotal role in TLR3 ligand, Poly(I:C)-induced cell death when cIAPs activity was inhibited and loss of RIPK1 enhanced Poly(I:C)-induced invasion which was partially reversed by Smac mimetic.	Poly I-C	145-154	toll like receptor 3	Homo sapiens	42-46
33050324-7	2020	Furthermore, activation of IRF3 by polyinosinic-polycytidylic acid (poly I:C) produced a cooperative effect with TNF-alpha for MIP-1alpha/CCL3 production that was comparable to stearic acid.	Poly I-C	35-66	C-C motif chemokine ligand 3	Homo sapiens	127-137
33036630-17	2020	CONCLUSION: RIPK1 plays a pivotal role in TLR3 ligand, Poly(I:C)-induced cell death when cIAPs activity was inhibited and loss of RIPK1 enhanced Poly(I:C)-induced invasion which was partially reversed by Smac mimetic.	Poly I-C	145-154	receptor interacting serine/threonine kinase 1	Homo sapiens	130-135
33050324-7	2020	Furthermore, activation of IRF3 by polyinosinic-polycytidylic acid (poly I:C) produced a cooperative effect with TNF-alpha for MIP-1alpha/CCL3 production that was comparable to stearic acid.	Poly I-C	35-66	C-C motif chemokine ligand 3	Homo sapiens	138-142
33162975-7	2020	Also, after poly I:C stimulation, they predominantly produced IL-12p40a and matured as indicated by the increase of MHC-I, MHC-II, and CD80/86.	Poly I-C	12-20	CD80 molecule	Sus scrofa	135-139
32755662-5	2020	Counterintuitively, we found that the MNV replicase NS7 enhances the activation of poly (I:C)-induced IFN response and the transcription of downstream interferon-stimulated genes (ISGs).	Poly I-C	83-93	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	52-55
32988857-3	2020	The TLR3 activator polyinosinic:polycytidylic acid [poly(I:C)] induces apoptosis in various types of cancer but not in the most aggressive breast cancer cell lines.	Poly I-C	19-50	toll like receptor 3	Homo sapiens	4-8
32988857-3	2020	The TLR3 activator polyinosinic:polycytidylic acid [poly(I:C)] induces apoptosis in various types of cancer but not in the most aggressive breast cancer cell lines.	Poly I-C	52-61	toll like receptor 3	Homo sapiens	4-8
32988857-7	2020	RESULTS: Poly(I:C) increased expression of HIF1alpha and its targets BCL2 apoptosis regulator and c-MYC.	Poly I-C	9-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-52
32720073-10	2020	Furthermore, the hippocampus of the offspring rats of both the poly (I:C)- and LPS-treated groups showed increased signs of lipid peroxidation, diminished total antioxidant content, and differentially upregulated expression of inflammatory (TNFalpha, IL6, and IL1beta), and apoptotic (Bax, Cas3, and Cas9) genes but decreased expression of neuroprotective (BDNF and Bcl2) genes.	Poly I-C	63-73	tumor necrosis factor	Rattus norvegicus	241-249
32988857-7	2020	RESULTS: Poly(I:C) increased expression of HIF1alpha and its targets BCL2 apoptosis regulator and c-MYC.	Poly I-C	9-18	BCL2 apoptosis regulator	Homo sapiens	69-93
32988857-7	2020	RESULTS: Poly(I:C) increased expression of HIF1alpha and its targets BCL2 apoptosis regulator and c-MYC.	Poly I-C	9-18	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	98-103
32988857-8	2020	Moreover, using pharmacological or genetic HIF1 inhibition, reduction of poly(I:C)-induced expression of HIF1alpha was paralleled by lowering of c-MYC and increased sensitivity to poly(I:C)-induced apoptosis, demonstrating the crucial role of this factor.	Poly I-C	73-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-47
32988857-8	2020	Moreover, using pharmacological or genetic HIF1 inhibition, reduction of poly(I:C)-induced expression of HIF1alpha was paralleled by lowering of c-MYC and increased sensitivity to poly(I:C)-induced apoptosis, demonstrating the crucial role of this factor.	Poly I-C	73-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-114
32988857-8	2020	Moreover, using pharmacological or genetic HIF1 inhibition, reduction of poly(I:C)-induced expression of HIF1alpha was paralleled by lowering of c-MYC and increased sensitivity to poly(I:C)-induced apoptosis, demonstrating the crucial role of this factor.	Poly I-C	73-82	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	145-150
32988857-8	2020	Moreover, using pharmacological or genetic HIF1 inhibition, reduction of poly(I:C)-induced expression of HIF1alpha was paralleled by lowering of c-MYC and increased sensitivity to poly(I:C)-induced apoptosis, demonstrating the crucial role of this factor.	Poly I-C	180-189	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-47
32988857-8	2020	Moreover, using pharmacological or genetic HIF1 inhibition, reduction of poly(I:C)-induced expression of HIF1alpha was paralleled by lowering of c-MYC and increased sensitivity to poly(I:C)-induced apoptosis, demonstrating the crucial role of this factor.	Poly I-C	180-189	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-114
32859727-4	2020	First, the transcription of IFN activated by polyinosinic/polycytidylic acid (poly I:C), spring viremia of carp virus, or retinoic acid-inducible gene I (RIG-I)-like receptor pathway components were significantly suppressed by RBM47.	Poly I-C	45-76	RNA binding motif protein 47	Homo sapiens	227-232
33109186-14	2020	TLR3 activation by polyI:C readily induced adenosine triphosphate (ATP) release from the trachea and increases of cilia-driven flow and CBF in WT culture, but not in TLR3-KO culture.	Poly I-C	19-26	toll like receptor 3	Homo sapiens	0-4
32720073-10	2020	Furthermore, the hippocampus of the offspring rats of both the poly (I:C)- and LPS-treated groups showed increased signs of lipid peroxidation, diminished total antioxidant content, and differentially upregulated expression of inflammatory (TNFalpha, IL6, and IL1beta), and apoptotic (Bax, Cas3, and Cas9) genes but decreased expression of neuroprotective (BDNF and Bcl2) genes.	Poly I-C	63-73	interleukin 6	Rattus norvegicus	251-254
32720073-10	2020	Furthermore, the hippocampus of the offspring rats of both the poly (I:C)- and LPS-treated groups showed increased signs of lipid peroxidation, diminished total antioxidant content, and differentially upregulated expression of inflammatory (TNFalpha, IL6, and IL1beta), and apoptotic (Bax, Cas3, and Cas9) genes but decreased expression of neuroprotective (BDNF and Bcl2) genes.	Poly I-C	63-73	interleukin 1 alpha	Rattus norvegicus	260-267
32720073-10	2020	Furthermore, the hippocampus of the offspring rats of both the poly (I:C)- and LPS-treated groups showed increased signs of lipid peroxidation, diminished total antioxidant content, and differentially upregulated expression of inflammatory (TNFalpha, IL6, and IL1beta), and apoptotic (Bax, Cas3, and Cas9) genes but decreased expression of neuroprotective (BDNF and Bcl2) genes.	Poly I-C	63-73	BCL2 associated X, apoptosis regulator	Rattus norvegicus	285-288
32720073-10	2020	Furthermore, the hippocampus of the offspring rats of both the poly (I:C)- and LPS-treated groups showed increased signs of lipid peroxidation, diminished total antioxidant content, and differentially upregulated expression of inflammatory (TNFalpha, IL6, and IL1beta), and apoptotic (Bax, Cas3, and Cas9) genes but decreased expression of neuroprotective (BDNF and Bcl2) genes.	Poly I-C	63-73	brain-derived neurotrophic factor	Rattus norvegicus	357-361
32720073-10	2020	Furthermore, the hippocampus of the offspring rats of both the poly (I:C)- and LPS-treated groups showed increased signs of lipid peroxidation, diminished total antioxidant content, and differentially upregulated expression of inflammatory (TNFalpha, IL6, and IL1beta), and apoptotic (Bax, Cas3, and Cas9) genes but decreased expression of neuroprotective (BDNF and Bcl2) genes.	Poly I-C	63-73	BCL2, apoptosis regulator	Rattus norvegicus	366-370
33004906-4	2020	In the current study, miR22 expression showed a tissues-specific difference in the poly(I:C) induced inflammatory mouse lung and brain tissues.	Poly I-C	83-92	microRNA 22	Mus musculus	22-27
32988406-4	2020	On the other hand, anti-inflammatory MSC2 is induced by the activation of TLR3 with Poly(I:C).	Poly I-C	84-93	toll like receptor 3	Homo sapiens	74-78
32878999-2	2020	We show that the E3 ubiquitin ligase TRIM3 is mainly located in the Golgi apparatus and transported to the early endosomes upon stimulation with the dsRNA analog poly(I:C).	Poly I-C	162-171	tripartite motif-containing 3	Mus musculus	37-42
32878999-3	2020	TRIM3 mediates K63-linked polyubiquitination of TLR3 at K831, which is enhanced following poly(I:C) stimulation.	Poly I-C	90-99	tripartite motif-containing 3	Mus musculus	0-5
32878999-3	2020	TRIM3 mediates K63-linked polyubiquitination of TLR3 at K831, which is enhanced following poly(I:C) stimulation.	Poly I-C	90-99	toll-like receptor 3	Mus musculus	48-52
32878999-6	2020	Trim3 -/- cells and mice express lower levels of antiviral genes and show lower levels of inflammatory response following poly(I:C) but not lipopolysaccharide (LPS) stimulation.	Poly I-C	122-131	tripartite motif-containing 3	Mus musculus	0-5
32747502-5	2020	When ectopically expressed, ORF8b inhibited IRF3-mediated IFN-beta expression induced by Sendai virus and poly(I:C).	Poly I-C	106-115	ORF8b protein	Middle East respiratory syndrome-related coronavirus	28-33
32747502-5	2020	When ectopically expressed, ORF8b inhibited IRF3-mediated IFN-beta expression induced by Sendai virus and poly(I:C).	Poly I-C	106-115	interferon regulatory factor 3	Homo sapiens	44-48
32747502-5	2020	When ectopically expressed, ORF8b inhibited IRF3-mediated IFN-beta expression induced by Sendai virus and poly(I:C).	Poly I-C	106-115	IFN1@	Homo sapiens	58-66
32524263-3	2020	After treatment with poly(I:C)-LMW, poly (I:C)-LMW/LyoVec, and Imiquimod, the replication of IBV was significantly suppressed after 24 h. However, treatment with TLR3 pathway inhibitors such as Pepinh-TRIF, celastrol, chloroquine, and BX795 resulted in increased replication of IBV after 36 h. These results also showed that chloroquine and celastrol were most effective inhibitors of the antiviral response at 48 hpi.	Poly I-C	36-47	toll like receptor 3	Homo sapiens	162-166
32881988-5	2020	NS5 inhibited IFN-alpha and beta production induced by poly(I:C) stimulation and harbored 11 amino acid variations, of which the NS5-V372A and NS5-H386Y variations were identified to co-contribute to the differences in IFN-alpha and beta induction and replication efficiency between the strains.	Poly I-C	55-64	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-3
32881988-5	2020	NS5 inhibited IFN-alpha and beta production induced by poly(I:C) stimulation and harbored 11 amino acid variations, of which the NS5-V372A and NS5-H386Y variations were identified to co-contribute to the differences in IFN-alpha and beta induction and replication efficiency between the strains.	Poly I-C	55-64	interferon alpha 2	Homo sapiens	14-23
32881988-5	2020	NS5 inhibited IFN-alpha and beta production induced by poly(I:C) stimulation and harbored 11 amino acid variations, of which the NS5-V372A and NS5-H386Y variations were identified to co-contribute to the differences in IFN-alpha and beta induction and replication efficiency between the strains.	Poly I-C	55-64	interferon alpha 2	Homo sapiens	219-228
32923700-9	2020	Janus kinase inhibitor I decreased the amount of BAFF produced in BEAS-2B cells upon stimulation with IFN-beta and poly I:C.	Poly I-C	115-123	TNF superfamily member 13b	Homo sapiens	49-53
32923700-12	2020	The stimulation of poly I:C produced BAFF from BEAS2B cells via IFN-beta production and the JAK/signal transducer and activator of transcription pathway played an important role in BAFF production in BEAS-2B cells.	Poly I-C	19-27	TNF superfamily member 13b	Homo sapiens	37-41
32923700-12	2020	The stimulation of poly I:C produced BAFF from BEAS2B cells via IFN-beta production and the JAK/signal transducer and activator of transcription pathway played an important role in BAFF production in BEAS-2B cells.	Poly I-C	19-27	IFN1@	Homo sapiens	64-72
32923700-12	2020	The stimulation of poly I:C produced BAFF from BEAS2B cells via IFN-beta production and the JAK/signal transducer and activator of transcription pathway played an important role in BAFF production in BEAS-2B cells.	Poly I-C	19-27	TNF superfamily member 13b	Homo sapiens	181-185
32623773-5	2020	RESULTS: Our in vitro experiments showed that the poly(I:C)-induced innate production of IFN-lambda in human infant AECs is regulated by: I) p38-MAPK/NF-kB dependent mechanism; and II) exposure to pro-inflammatory signals such as IL1beta.	Poly I-C	50-59	mitogen-activated protein kinase 14	Homo sapiens	141-149
32623773-5	2020	RESULTS: Our in vitro experiments showed that the poly(I:C)-induced innate production of IFN-lambda in human infant AECs is regulated by: I) p38-MAPK/NF-kB dependent mechanism; and II) exposure to pro-inflammatory signals such as IL1beta.	Poly I-C	50-59	interleukin 1 alpha	Homo sapiens	230-237
32078434-9	2020	The inhibitory effects of poly(I:C) on both Cx43 expression and GJIC activity were attenuated by NAC and by c-Jun NH2-terminal kinase (JNK) inhibitor II.Conclusions: Poly(I:C) inhibited Cx43 expression and GJIC in cultured HCFs, possibly as a result of the associated up-regulation of microRNA-21.	Poly I-C	26-34	gap junction protein alpha 1	Homo sapiens	44-48
32078434-9	2020	The inhibitory effects of poly(I:C) on both Cx43 expression and GJIC activity were attenuated by NAC and by c-Jun NH2-terminal kinase (JNK) inhibitor II.Conclusions: Poly(I:C) inhibited Cx43 expression and GJIC in cultured HCFs, possibly as a result of the associated up-regulation of microRNA-21.	Poly I-C	26-34	X-linked Kx blood group	Homo sapiens	97-100
32078434-9	2020	The inhibitory effects of poly(I:C) on both Cx43 expression and GJIC activity were attenuated by NAC and by c-Jun NH2-terminal kinase (JNK) inhibitor II.Conclusions: Poly(I:C) inhibited Cx43 expression and GJIC in cultured HCFs, possibly as a result of the associated up-regulation of microRNA-21.	Poly I-C	26-34	gap junction protein alpha 1	Homo sapiens	186-190
32078434-9	2020	The inhibitory effects of poly(I:C) on both Cx43 expression and GJIC activity were attenuated by NAC and by c-Jun NH2-terminal kinase (JNK) inhibitor II.Conclusions: Poly(I:C) inhibited Cx43 expression and GJIC in cultured HCFs, possibly as a result of the associated up-regulation of microRNA-21.	Poly I-C	166-174	gap junction protein alpha 1	Homo sapiens	44-48
32078434-9	2020	The inhibitory effects of poly(I:C) on both Cx43 expression and GJIC activity were attenuated by NAC and by c-Jun NH2-terminal kinase (JNK) inhibitor II.Conclusions: Poly(I:C) inhibited Cx43 expression and GJIC in cultured HCFs, possibly as a result of the associated up-regulation of microRNA-21.	Poly I-C	166-174	X-linked Kx blood group	Homo sapiens	97-100
32078434-9	2020	The inhibitory effects of poly(I:C) on both Cx43 expression and GJIC activity were attenuated by NAC and by c-Jun NH2-terminal kinase (JNK) inhibitor II.Conclusions: Poly(I:C) inhibited Cx43 expression and GJIC in cultured HCFs, possibly as a result of the associated up-regulation of microRNA-21.	Poly I-C	166-174	gap junction protein alpha 1	Homo sapiens	186-190
32078434-10	2020	Poly(I:C) also increased oxidative stress in these cells, and such stress together with signaling by the MAPK JNK was implicated in the effects of poly(I:C) on Cx43 expression and GJIC activity.	Poly I-C	0-8	gap junction protein alpha 1	Homo sapiens	160-164
32078434-10	2020	Poly(I:C) also increased oxidative stress in these cells, and such stress together with signaling by the MAPK JNK was implicated in the effects of poly(I:C) on Cx43 expression and GJIC activity.	Poly I-C	147-156	gap junction protein alpha 1	Homo sapiens	160-164
32580635-0	2020	Double-Stranded Structure of the Polyinosinic-Polycytidylic Acid Molecule to Elicit TLR3 Signaling and Adjuvant Activity in Murine Intranasal A(H1N1)pdm09 Influenza Vaccination.	Poly I-C	33-64	toll-like receptor 3	Mus musculus	84-88
32540504-6	2020	After challenged by Streptococcus agalactiae, Poly(I:C) and LPS in vivo and in vitro, OnCXCL12 is transcriptionally up-regulated in immune tissues and cells significantly.	Poly I-C	46-55	stromal cell-derived factor 1	Oreochromis niloticus	86-94
32565351-2	2020	Toll-like receptor (TLR) agonists like CpG and polyI:C are potent stimulators of non-specific, pro-inflammatory immune responses, targeting TLR9 and TLR3, respectively.	Poly I-C	47-54	toll like receptor 9	Homo sapiens	140-144
32565351-2	2020	Toll-like receptor (TLR) agonists like CpG and polyI:C are potent stimulators of non-specific, pro-inflammatory immune responses, targeting TLR9 and TLR3, respectively.	Poly I-C	47-54	toll like receptor 3	Homo sapiens	149-153
32565351-5	2020	Immunostimulants such as CpG and polyI:C cannot be completely immobilized, however, since the target TLR9 and TLR3 are located intracellularly.	Poly I-C	33-40	toll like receptor 9	Homo sapiens	101-105
32565351-5	2020	Immunostimulants such as CpG and polyI:C cannot be completely immobilized, however, since the target TLR9 and TLR3 are located intracellularly.	Poly I-C	33-40	toll like receptor 3	Homo sapiens	110-114
32738418-4	2020	MATERIALS AND METHODS: The role of CYLD in PD-L1 expression was assessed by knockdown of CYLD in TET cells upon stimulation with interferon gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) or polyinosinic-polycytidylic acid (poly I:C).	Poly I-C	202-233	CD274 molecule	Homo sapiens	43-48
32824929-10	2020	The response of NB cells to CDDP and poly(I:C) was potentiated by Dac in association with increased mtROS, which was blunted in rho0 cells.	Poly I-C	37-46	arylacetamide deacetylase	Homo sapiens	66-69
32824929-12	2020	Dac can potentiate the cytotoxic effects of CDDP and poly(I:C) in NB cells.	Poly I-C	53-62	arylacetamide deacetylase	Homo sapiens	0-3
32824595-7	2020	Corroborating in vitro data, Myd88-/- knockout mice downregulated TNF, CXCL1; and phospho-p65 and phospho-IRF3 nuclear localization, upon poly I:C treatment in a mouse model of skin infection.	Poly I-C	138-146	myeloid differentiation primary response gene 88	Mus musculus	29-34
32922375-4	2020	Furthermore, transfection with poly(I:C) and treatment with interferon beta (IFN-beta) induced the ZC3HAV1 expression.	Poly I-C	31-40	zinc finger CCCH-type containing, antiviral 1	Homo sapiens	99-106
32849638-0	2020	HDAC6 Mediates Poly (I:C)-Induced TBK1 and Akt Phosphorylation in Macrophages.	Poly I-C	15-25	histone deacetylase 6	Mus musculus	0-5
32849638-0	2020	HDAC6 Mediates Poly (I:C)-Induced TBK1 and Akt Phosphorylation in Macrophages.	Poly I-C	15-25	TANK-binding kinase 1	Mus musculus	34-38
32849638-0	2020	HDAC6 Mediates Poly (I:C)-Induced TBK1 and Akt Phosphorylation in Macrophages.	Poly I-C	15-25	thymoma viral proto-oncogene 1	Mus musculus	43-46
32849638-6	2020	In the present study, we investigated the potential role of HDAC6 in macrophage anti-viral responses by examining poly (I:C)-induced IFN-beta and IL-10 production in mouse bone marrow-derived macrophages (BMDMs).	Poly I-C	114-124	interferon alpha	Mus musculus	133-141
32849638-7	2020	We also investigated the role of HDAC6 in poly (I:C)-induced anti-viral signaling such as TBK1, GSK-3beta, and Akt activation in mouse BMDMs.	Poly I-C	42-52	TANK-binding kinase 1	Mus musculus	90-94
32849638-7	2020	We also investigated the role of HDAC6 in poly (I:C)-induced anti-viral signaling such as TBK1, GSK-3beta, and Akt activation in mouse BMDMs.	Poly I-C	42-52	glycogen synthase kinase 3 alpha	Mus musculus	96-105
32849638-7	2020	We also investigated the role of HDAC6 in poly (I:C)-induced anti-viral signaling such as TBK1, GSK-3beta, and Akt activation in mouse BMDMs.	Poly I-C	42-52	thymoma viral proto-oncogene 1	Mus musculus	111-114
32849638-8	2020	Our data showed that HDAC6 deletion enhanced poly (I:C)-induced INF-beta expression in macrophages by up-regulating TBK1 activity and eliminating the inhibitory regulation of GSK-3beta.	Poly I-C	45-55	histone deacetylase 6	Mus musculus	21-26
32849638-8	2020	Our data showed that HDAC6 deletion enhanced poly (I:C)-induced INF-beta expression in macrophages by up-regulating TBK1 activity and eliminating the inhibitory regulation of GSK-3beta.	Poly I-C	45-55	TANK-binding kinase 1	Mus musculus	116-120
32849638-8	2020	Our data showed that HDAC6 deletion enhanced poly (I:C)-induced INF-beta expression in macrophages by up-regulating TBK1 activity and eliminating the inhibitory regulation of GSK-3beta.	Poly I-C	45-55	glycogen synthase kinase 3 alpha	Mus musculus	175-184
32849638-9	2020	Furthermore, HDAC6 deletion inhibited poly (I:C)-induced suppressor cytokine IL-10 production in the BMDMs, which was associated with the inhibition of Akt activation.	Poly I-C	38-48	histone deacetylase 6	Mus musculus	13-18
32849638-9	2020	Furthermore, HDAC6 deletion inhibited poly (I:C)-induced suppressor cytokine IL-10 production in the BMDMs, which was associated with the inhibition of Akt activation.	Poly I-C	38-48	interleukin 10	Mus musculus	77-82
32849638-9	2020	Furthermore, HDAC6 deletion inhibited poly (I:C)-induced suppressor cytokine IL-10 production in the BMDMs, which was associated with the inhibition of Akt activation.	Poly I-C	38-48	thymoma viral proto-oncogene 1	Mus musculus	152-155
32643603-7	2020	Ad5-hACE2-transduced mice enabled rapid assessments of a vaccine candidate, of human convalescent plasma, and of two antiviral therapies (poly I:C and remdesivir).	Poly I-C	138-146	Alzheimer disease, familial, type 5	Homo sapiens	0-3
32643603-7	2020	Ad5-hACE2-transduced mice enabled rapid assessments of a vaccine candidate, of human convalescent plasma, and of two antiviral therapies (poly I:C and remdesivir).	Poly I-C	138-146	angiotensin converting enzyme 2	Homo sapiens	4-9
32903758-2	2020	We have previously shown that Polyriboinosinic-polyribocytidylic acid (poly I:C) induced maternal immune activation in mice caused histological changes in the hippocampal CA1 area of offspring during the developmental period and impaired sensorimotor gating in offspring during adulthood, resulting in behavioral changes.	Poly I-C	30-69	carbonic anhydrase 1	Mus musculus	171-174
32903758-4	2020	We studied the effect of prenatal poly I:C treatment on synaptic transmission of hippocampal CA1 pyramidal cells in postnatal and adult offspring.	Poly I-C	34-42	carbonic anhydrase 1	Mus musculus	93-96
32590296-9	2020	CD141+ DCs showed a reduced response to the TLR3 agonist poly (I:C) in both groups of patients.	Poly I-C	57-67	thrombomodulin	Homo sapiens	0-5
32590296-9	2020	CD141+ DCs showed a reduced response to the TLR3 agonist poly (I:C) in both groups of patients.	Poly I-C	57-67	toll like receptor 3	Homo sapiens	44-48
32334130-6	2020	We also explored how a pre-treatment with PACAP could enhance antiviral immune response using poly (I:C) as viral mimic.	Poly I-C	94-104	adenylate cyclase activating polypeptide 1	Homo sapiens	42-47
32334130-7	2020	Interferons and IL-8 transcription levels were enhanced when PACAP was added 24 h previous to poly (I:C) exposure.	Poly I-C	94-104	adenylate cyclase activating polypeptide 1	Homo sapiens	61-66
32535733-5	2020	The reduction rate of worm burden showed that TLR3 agonist poly(I:C) significantly reduced T. spiralis infection rather than TLR4, TLR8, and TLR9 agonists (p < 0.05).	Poly I-C	59-68	toll-like receptor 3	Mus musculus	46-50
32378521-0	2020	Interleukin-19 enhances cytokine production induced by lipopolysaccharide and inhibits cytokine production induced by polyI:C in BALB/c mice.	Poly I-C	118-125	interleukin 19	Mus musculus	0-14
32378521-9	2020	Interestingly, the experiments using polyI:C revealed that production of some cytokines was enhanced in IL-19 KO mice.	Poly I-C	37-44	interleukin 19	Mus musculus	104-109
32641167-0	2020	The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma.	Poly I-C	36-42	interleukin 17A	Mus musculus	4-9
32641167-0	2020	The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma.	Poly I-C	36-42	interleukin 17 receptor E	Mus musculus	19-26
32641167-3	2020	Polyinosinic:polycytidylic acid (pIC) mimics viral infections through binding to pattern recognition receptors (e.g. TLR-3).	Poly I-C	33-36	toll-like receptor 3	Mus musculus	117-122
32641167-11	2020	Treatment of mice with pIC exacerbated pulmonary inflammation in sensitized and OVA-challenged mice in an IL-17RE-dependent manner.	Poly I-C	23-26	interleukin 17 receptor E	Mus musculus	106-113
32733469-3	2020	The activation of the endosomal toll-like receptor 3 by its agonist poly(I:C) has shown to efficiently drive this polarization process.	Poly I-C	68-77	toll like receptor 3	Homo sapiens	32-52
32609043-9	2022	In addition, overexpression of duTLR7 by stimulating with poly(I:C) significantly promoted IFN-beta, NF-kappaB, IRF7, TRIF, Mx, STAT1 and STAT2 expressions.	Poly I-C	58-67	interferon regulatory factor 7	Anas platyrhynchos	112-116
32609043-9	2022	In addition, overexpression of duTLR7 by stimulating with poly(I:C) significantly promoted IFN-beta, NF-kappaB, IRF7, TRIF, Mx, STAT1 and STAT2 expressions.	Poly I-C	58-67	TIR domain-containing adapter molecule 1	Anas platyrhynchos	118-122
32609043-9	2022	In addition, overexpression of duTLR7 by stimulating with poly(I:C) significantly promoted IFN-beta, NF-kappaB, IRF7, TRIF, Mx, STAT1 and STAT2 expressions.	Poly I-C	58-67	Signal transducer and activator of transcription 1-alpha/beta	Anas platyrhynchos	128-133
32213302-7	2020	In vitro, TNFSF15 gene expression was up-regulated by lipopolysaccharide, polyinosinic:polycytidylic acid (poly I:C) and rock bream iridovirus (RBIV) in head kidney, while up-regulated by poly I:C and RBIV at later time in spleen.	Poly I-C	74-105	TNF superfamily member 15	Homo sapiens	10-17
32213302-7	2020	In vitro, TNFSF15 gene expression was up-regulated by lipopolysaccharide, polyinosinic:polycytidylic acid (poly I:C) and rock bream iridovirus (RBIV) in head kidney, while up-regulated by poly I:C and RBIV at later time in spleen.	Poly I-C	107-115	TNF superfamily member 15	Homo sapiens	10-17
32213302-7	2020	In vitro, TNFSF15 gene expression was up-regulated by lipopolysaccharide, polyinosinic:polycytidylic acid (poly I:C) and rock bream iridovirus (RBIV) in head kidney, while up-regulated by poly I:C and RBIV at later time in spleen.	Poly I-C	188-196	TNF superfamily member 15	Homo sapiens	10-17
32247830-8	2020	Meanwhile, KEGG enrichment analysis showed that the DEGs were mainly mapped on the immune pathways like "TNF signal pathway", "p53 signal pathway" and "JAK-STAT signal pathway", suggesting that these signal pathways may be responsible for the delayed peak of CyHV-2 infection in gibel carp after poly I:C treatment.	Poly I-C	296-304	tumor necrosis factor	Homo sapiens	105-108
32247830-8	2020	Meanwhile, KEGG enrichment analysis showed that the DEGs were mainly mapped on the immune pathways like "TNF signal pathway", "p53 signal pathway" and "JAK-STAT signal pathway", suggesting that these signal pathways may be responsible for the delayed peak of CyHV-2 infection in gibel carp after poly I:C treatment.	Poly I-C	296-304	tumor protein p53	Homo sapiens	127-130
32504419-3	2020	By using a previously established mouse model of depression induced by combined delivery of IFN-alpha and polyinosinic:polycytidylic acid (poly(I:C)), a TLR3 agonist, we provide evidence that IFN-alpha and poly(I:C) reduce apical dendritic spine density in the hippocampal CA1 area ex vivo via mechanisms involving decreased TrkB signaling.	Poly I-C	139-148	toll-like receptor 3	Mus musculus	153-157
32504419-3	2020	By using a previously established mouse model of depression induced by combined delivery of IFN-alpha and polyinosinic:polycytidylic acid (poly(I:C)), a TLR3 agonist, we provide evidence that IFN-alpha and poly(I:C) reduce apical dendritic spine density in the hippocampal CA1 area ex vivo via mechanisms involving decreased TrkB signaling.	Poly I-C	139-148	interferon alpha	Mus musculus	192-201
32504419-3	2020	By using a previously established mouse model of depression induced by combined delivery of IFN-alpha and polyinosinic:polycytidylic acid (poly(I:C)), a TLR3 agonist, we provide evidence that IFN-alpha and poly(I:C) reduce apical dendritic spine density in the hippocampal CA1 area ex vivo via mechanisms involving decreased TrkB signaling.	Poly I-C	139-148	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	325-329
32504419-4	2020	In vitro, IFN-alpha and poly(I:C) treatments required neuronal activity to reduce dendritic spine density and TrkB signaling.	Poly I-C	24-33	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	110-114
32342250-6	2020	Mostly in mouse fibroblasts and human endothelial cells, the Rnf213 levels showed prominent upregulation upon Poly(I:C)-triggered TLR3-mediated responses to dsRNA toxicity, as well as upon interferon gamma treatment.	Poly I-C	110-119	ring finger protein 213	Homo sapiens	61-67
32342250-6	2020	Mostly in mouse fibroblasts and human endothelial cells, the Rnf213 levels showed prominent upregulation upon Poly(I:C)-triggered TLR3-mediated responses to dsRNA toxicity, as well as upon interferon gamma treatment.	Poly I-C	110-119	toll like receptor 3	Homo sapiens	130-134
32714147-7	2020	Results: Specifically, ISH reveals that in the brain of prenatal poly(I:C)-exposed mouse offspring in the MIA model (gestation day 9), mRNA expression of the genes SOX10, MAG and Tf were generally reduced in the limbic system including the hippocampus, retrosplenial cortex and parahippocampal gyrus on either side of the hemispheres.	Poly I-C	65-74	SRY (sex determining region Y)-box 10	Mus musculus	164-169
32714147-7	2020	Results: Specifically, ISH reveals that in the brain of prenatal poly(I:C)-exposed mouse offspring in the MIA model (gestation day 9), mRNA expression of the genes SOX10, MAG and Tf were generally reduced in the limbic system including the hippocampus, retrosplenial cortex and parahippocampal gyrus on either side of the hemispheres.	Poly I-C	65-74	myelin-associated glycoprotein	Mus musculus	171-174
32714147-7	2020	Results: Specifically, ISH reveals that in the brain of prenatal poly(I:C)-exposed mouse offspring in the MIA model (gestation day 9), mRNA expression of the genes SOX10, MAG and Tf were generally reduced in the limbic system including the hippocampus, retrosplenial cortex and parahippocampal gyrus on either side of the hemispheres.	Poly I-C	65-74	transferrin	Mus musculus	179-181
32366718-9	2020	Pin2[G] showed superior immunomodulatory activity in increasing chemokine production by a human bronchial cell line and suppressing poly(IC)-induced pro-inflammatory IL6 production.	Poly I-C	132-140	telomeric repeat binding factor 1	Homo sapiens	0-4
32366718-9	2020	Pin2[G] showed superior immunomodulatory activity in increasing chemokine production by a human bronchial cell line and suppressing poly(IC)-induced pro-inflammatory IL6 production.	Poly I-C	132-140	interleukin 6	Homo sapiens	166-169
32532953-6	2020	Then, by using Poly(I:C) to imitate virus invasion, we clarified that virus invasion significantly activated MDA5 and further potentiated the keratinocyte-derived CXCL10 and CXCL16 which are the two vital chemokines for the cutaneous infiltration of CD8+ T cells in vitiligo.	Poly I-C	15-24	interferon induced with helicase C domain 1	Homo sapiens	109-113
32532953-6	2020	Then, by using Poly(I:C) to imitate virus invasion, we clarified that virus invasion significantly activated MDA5 and further potentiated the keratinocyte-derived CXCL10 and CXCL16 which are the two vital chemokines for the cutaneous infiltration of CD8+ T cells in vitiligo.	Poly I-C	15-24	C-X-C motif chemokine ligand 10	Homo sapiens	163-169
32582210-8	2020	Expression of Notch1 and the Notch ligand, delta-like ligand 1, which are both highly implicated in maintenance of NPCs and nervous system development, was increased following PolyI:C exposure.	Poly I-C	176-183	notch receptor 1	Rattus norvegicus	14-20
32582573-6	2020	The induction of expression of type I IFN in DF-1 cells stimulated with polyI:C (measured by an IFN-beta luciferase reporter assay) was significantly reduced in cells expressing ectopic VP4 from UK661 (p < 0.05), but was higher in cells expressing ectopic VP4 from F52/70.	Poly I-C	72-79	interferon	Gallus gallus	96-104
32193100-6	2020	Sirt1 activators resveratrol (RSV) and SRT1720 (SRT) ameliorated poly I:C-induced hepatic injury observed via histopathologic analysis and decreased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in the PBC murine model.	Poly I-C	65-73	sirtuin 1	Mus musculus	0-5
32621945-1	2020	Recent studies highlight that infection with Coxsackievirus B3, Venezuelan equine encephalitis virus (VEEV), Marburg virus, or stimulation using poly I:C (dsRNA), upregulates the signaling adaptor protein MyD88 and impairs the host antiviral type I interferon (IFN) responses.	Poly I-C	145-153	MYD88 innate immune signal transduction adaptor	Homo sapiens	205-210
32302698-3	2020	Cell cultures from 15 controls, 14 asthma and 11 COPD patients were stimulated with IL-13 and poly I:C for 24 h. Co-cultivation of epithelial cells with moMphis and moDCs increased TSLP level only in asthma and the effect of IL-13 and poly I:C stimulation differed in all groups.	Poly I-C	94-102	thymic stromal lymphopoietin	Homo sapiens	181-185
32221618-7	2020	Co-stimulation with poly I:C and LL-37 enhanced pro-inflammatory IL-6 and MCP-1 transcripts several fold compared to treatment with poly I:C or LL-37 alone.	Poly I-C	20-28	C-C motif chemokine ligand 2	Homo sapiens	74-79
32221618-7	2020	Co-stimulation with poly I:C and LL-37 enhanced pro-inflammatory IL-6 and MCP-1 transcripts several fold compared to treatment with poly I:C or LL-37 alone.	Poly I-C	20-28	cathelicidin antimicrobial peptide	Homo sapiens	144-149
32221618-7	2020	Co-stimulation with poly I:C and LL-37 enhanced pro-inflammatory IL-6 and MCP-1 transcripts several fold compared to treatment with poly I:C or LL-37 alone.	Poly I-C	132-140	cathelicidin antimicrobial peptide	Homo sapiens	33-38
32221618-8	2020	Poly I:C increased IL-6 and MCP-1 protein production, and this effect was potentiated by LL-37.	Poly I-C	0-8	interleukin 6	Homo sapiens	19-23
32221618-8	2020	Poly I:C increased IL-6 and MCP-1 protein production, and this effect was potentiated by LL-37.	Poly I-C	0-8	C-C motif chemokine ligand 2	Homo sapiens	28-33
32221618-8	2020	Poly I:C increased IL-6 and MCP-1 protein production, and this effect was potentiated by LL-37.	Poly I-C	0-8	cathelicidin antimicrobial peptide	Homo sapiens	89-94
32799169-5	2020	In this study, we demonstrated that NSP1 of PRRSV-2 indirectly blocked extracellular signal-regulated kinase (ERK) signaling in polyriboinosinic polyribocytidylic acid (Poly I:C) stimulated pig macrophages (3D4/31 cells).	Poly I-C	128-167	SH2 domain containing 3A	Homo sapiens	36-40
32799169-5	2020	In this study, we demonstrated that NSP1 of PRRSV-2 indirectly blocked extracellular signal-regulated kinase (ERK) signaling in polyriboinosinic polyribocytidylic acid (Poly I:C) stimulated pig macrophages (3D4/31 cells).	Poly I-C	128-167	mitogen-activated protein kinase 1	Homo sapiens	110-113
32193100-4	2020	Consistent with clinical results, a PBC murine model showed that levels of Sirt1 significantly decreased in the liver and Kupffer cells of mice treated with polyinosinic/polycytidylic acid (poly I:C) for 16 weeks.	Poly I-C	157-188	sirtuin 1	Mus musculus	75-80
32193100-4	2020	Consistent with clinical results, a PBC murine model showed that levels of Sirt1 significantly decreased in the liver and Kupffer cells of mice treated with polyinosinic/polycytidylic acid (poly I:C) for 16 weeks.	Poly I-C	190-198	sirtuin 1	Mus musculus	75-80
32193100-5	2020	A TAK1 inhibitor (NG25) prevented the poly I:C-induced Sirt1 protein level decreasing in Kupffer cells but not MAPK inhibitor.	Poly I-C	38-46	mitogen-activated protein kinase kinase kinase 7	Mus musculus	2-6
32193100-5	2020	A TAK1 inhibitor (NG25) prevented the poly I:C-induced Sirt1 protein level decreasing in Kupffer cells but not MAPK inhibitor.	Poly I-C	38-46	sirtuin 1	Mus musculus	55-60
32193100-7	2020	Furthermore, Sirt1 activators significantly reduced pro-inflammatory cytokines levels such as interleukin-1 beta (IL-1beta), IL-6, interferon-gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in serum in poly I:C-induced mice.	Poly I-C	216-224	sirtuin 1	Mus musculus	13-18
32568266-1	2020	Polyinosinic:polycytidylic acid (poly[I:C]) can stimulate Toll-like receptor 3 (TLR3) signaling pathways.	Poly I-C	33-42	toll like receptor 3	Gallus gallus	80-84
32581060-5	2020	The immunogenicity and potential therapeutic activity of the vaccine in combination with cisplatin or with the TLR3 agonist molecules polyinosinic-polycytidylic acid (Poly IC) or Poly ICLC was evaluated in mice bearing subcutaneous or genital orthotopic HPV16 TC-1 tumors.	Poly I-C	134-165	toll-like receptor 3	Mus musculus	111-115
31957789-0	2020	Phospholipase A2 from Bee Venom Increases Poly(I:C)-induced Activation in Human Keratinocytes.	Poly I-C	42-51	phospholipase A2 group IB	Homo sapiens	0-16
31957789-2	2020	Although BV has been found to have an inhibitory effect on TLRs, we here show that BV enhances keratinocyte responses to polyinosinic-polycytidylic acid (poly(I:C)), a ligand for TLR3.	Poly I-C	121-152	toll like receptor 3	Homo sapiens	179-183
32266378-0	2020	Poly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice.	Poly I-C	0-9	Kell blood group	Mus musculus	80-83
32266378-6	2020	Recipient treatment with poly(I:C) led to breakthrough anti-KEL alloimmunization despite KELIg administration.	Poly I-C	25-34	Kell metallo-endopeptidase (Kell blood group)	Homo sapiens	60-63
32455939-3	2020	We investigated whether viral stimuli, polyinosinic: polycytidylic acid (poly(I:C)) or whole replicative murine cytomegalovirus (MCMV), could stimulate the expression of IL-10 in murine WAT using in vivo and ex vivo approaches.	Poly I-C	73-82	interleukin 10	Homo sapiens	170-175
32455939-4	2020	Our results showed that in vivo responses to systemic administration of poly(I:C) resulted in high levels of endogenously-produced IL-10 and IL-21 in WAT.	Poly I-C	72-81	interleukin 10	Mus musculus	131-136
32455939-4	2020	Our results showed that in vivo responses to systemic administration of poly(I:C) resulted in high levels of endogenously-produced IL-10 and IL-21 in WAT.	Poly I-C	72-81	interleukin 21	Homo sapiens	141-146
32455939-5	2020	In ex vivo WAT explants, a subset of B-cells increased their endogenous IL-10 expression in response to poly(I:C).	Poly I-C	104-113	interleukin 10	Mus musculus	72-77
32437407-0	2020	PD-L1 produced by HaCaT cells under polyinosinic-polycytidylic acid stimulation inhibits melanin production by B16F10 cells.	Poly I-C	36-67	CD274 molecule	Homo sapiens	0-5
32437407-9	2020	We found that polyinosinic-polycytidylic acid [poly(I:C)] stimulation induced PD-L1 secretion from HaCaT cells and that poly(I:C)-induced PD-L1 inhibited melanin production by B16F10 cells.	Poly I-C	14-45	CD274 molecule	Homo sapiens	78-83
32437407-9	2020	We found that polyinosinic-polycytidylic acid [poly(I:C)] stimulation induced PD-L1 secretion from HaCaT cells and that poly(I:C)-induced PD-L1 inhibited melanin production by B16F10 cells.	Poly I-C	47-56	CD274 molecule	Homo sapiens	78-83
32437407-9	2020	We found that polyinosinic-polycytidylic acid [poly(I:C)] stimulation induced PD-L1 secretion from HaCaT cells and that poly(I:C)-induced PD-L1 inhibited melanin production by B16F10 cells.	Poly I-C	120-129	CD274 molecule	Homo sapiens	138-143
32124477-4	2020	The cells were activated via toll-like receptor-3 (TLR3) by polyinosinic-polycytidylic acid sodium salt (poly I:C), mimicking viral infections.	Poly I-C	105-113	toll like receptor 3	Gallus gallus	29-49
32124477-4	2020	The cells were activated via toll-like receptor-3 (TLR3) by polyinosinic-polycytidylic acid sodium salt (poly I:C), mimicking viral infections.	Poly I-C	105-113	toll like receptor 3	Gallus gallus	51-55
32568266-1	2020	Polyinosinic:polycytidylic acid (poly[I:C]) can stimulate Toll-like receptor 3 (TLR3) signaling pathways.	Poly I-C	33-42	toll like receptor 3	Gallus gallus	58-78
32433485-5	2020	Following challenge of HeLa cells with the dsRNA-analog poly(I:C), PGAM5 oligomers and high levels of PGAM5 were found in mitochondrial aggregates.	Poly I-C	56-65	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	67-72
32433485-8	2020	Moreover, PGAM5 deficient mouse embryonic fibroblasts (MEFs) exhibited decreased phosphorylation levels of IRF3 and TBK1 when challenged with poly(I:C) intracellularly.	Poly I-C	142-151	phosphoglycerate mutase family member 5	Mus musculus	10-15
32433485-8	2020	Moreover, PGAM5 deficient mouse embryonic fibroblasts (MEFs) exhibited decreased phosphorylation levels of IRF3 and TBK1 when challenged with poly(I:C) intracellularly.	Poly I-C	142-151	interferon regulatory factor 3	Mus musculus	107-111
32433485-8	2020	Moreover, PGAM5 deficient mouse embryonic fibroblasts (MEFs) exhibited decreased phosphorylation levels of IRF3 and TBK1 when challenged with poly(I:C) intracellularly.	Poly I-C	142-151	TANK-binding kinase 1	Mus musculus	116-120
32133501-6	2020	Zcchc3-/- mice were more resistant to poly(I:C)- but not LPS-induced inflammatory death.	Poly I-C	38-47	zinc finger, CCHC domain containing 3	Mus musculus	0-6
32133501-7	2020	Mechanistically, ZCCHC3 promoted recruitment of TRIF to TLR3 after poly(I:C) stimulation.	Poly I-C	67-76	zinc finger, CCHC domain containing 3	Mus musculus	17-23
32133501-7	2020	Mechanistically, ZCCHC3 promoted recruitment of TRIF to TLR3 after poly(I:C) stimulation.	Poly I-C	67-76	toll-like receptor adaptor molecule 1	Mus musculus	48-52
32133501-7	2020	Mechanistically, ZCCHC3 promoted recruitment of TRIF to TLR3 after poly(I:C) stimulation.	Poly I-C	67-76	toll-like receptor 3	Mus musculus	56-60
32568266-4	2020	The expressions of TLR3, TLR4, TLR7, TLR15, TLR21, IL1B, and IL10 were increased in dose- and time-dependent manners by poly(I:C) treatment.	Poly I-C	120-129	toll like receptor 3	Gallus gallus	19-23
32568266-4	2020	The expressions of TLR3, TLR4, TLR7, TLR15, TLR21, IL1B, and IL10 were increased in dose- and time-dependent manners by poly(I:C) treatment.	Poly I-C	120-129	toll like receptor 4	Gallus gallus	25-29
32568266-4	2020	The expressions of TLR3, TLR4, TLR7, TLR15, TLR21, IL1B, and IL10 were increased in dose- and time-dependent manners by poly(I:C) treatment.	Poly I-C	120-129	toll like receptor 7	Gallus gallus	31-35
32568266-4	2020	The expressions of TLR3, TLR4, TLR7, TLR15, TLR21, IL1B, and IL10 were increased in dose- and time-dependent manners by poly(I:C) treatment.	Poly I-C	120-129	toll-like receptor 15	Gallus gallus	37-42
32660198-6	2020	In addition, the increased expression of CXCL-10 and CXCR3 in macrophage treated by poly (I:C) was also observed, suggesting the autocrine system existed in macrophages.	Poly I-C	84-94	C-X-C motif chemokine ligand 10	Sus scrofa	41-48
32568266-4	2020	The expressions of TLR3, TLR4, TLR7, TLR15, TLR21, IL1B, and IL10 were increased in dose- and time-dependent manners by poly(I:C) treatment.	Poly I-C	120-129	toll like receptor 21	Gallus gallus	44-49
32660198-6	2020	In addition, the increased expression of CXCL-10 and CXCR3 in macrophage treated by poly (I:C) was also observed, suggesting the autocrine system existed in macrophages.	Poly I-C	84-94	C-X-C motif chemokine receptor 3	Sus scrofa	53-58
32568266-4	2020	The expressions of TLR3, TLR4, TLR7, TLR15, TLR21, IL1B, and IL10 were increased in dose- and time-dependent manners by poly(I:C) treatment.	Poly I-C	120-129	interleukin 1, beta	Gallus gallus	51-55
32568266-4	2020	The expressions of TLR3, TLR4, TLR7, TLR15, TLR21, IL1B, and IL10 were increased in dose- and time-dependent manners by poly(I:C) treatment.	Poly I-C	120-129	interleukin 10	Gallus gallus	61-65
32518871-6	2020	Expression quantitative trait locus (eQTL) analysis in polyinosinic-polycytidylic acid (poly IC)-stimulated renal tubule cells revealed that single nucleotide polymorphism (SNP) rs513349 adjacent to BAK1 was a trans eQTL for APOL1 and a cis eQTL for BAK1; APOL1 and BAK1 were co-expressed in cells.	Poly I-C	55-86	BCL2 antagonist/killer 1	Homo sapiens	199-203
32009087-2	2020	Recent animal model on MIA induced by polyinosinic:polycytidylic acid, a mimic of viral infection, demonstrates that maternal interleukin 17A (IL-17A) signaling is required for the development of autism spectrum disorder (ASD)-like behaviors of offspring.	Poly I-C	38-69	interleukin 17A	Mus musculus	126-141
32009087-2	2020	Recent animal model on MIA induced by polyinosinic:polycytidylic acid, a mimic of viral infection, demonstrates that maternal interleukin 17A (IL-17A) signaling is required for the development of autism spectrum disorder (ASD)-like behaviors of offspring.	Poly I-C	38-69	interleukin 17A	Mus musculus	143-149
32377162-7	2020	Unexpectedly, poly (I:C) challenge of TNIP1-deficient cells restricted reepithelialization and reduced cell viability.	Poly I-C	14-24	TNFAIP3 interacting protein 1	Homo sapiens	38-43
32322251-5	2020	Orally administered MPL16 prior intraperitoneal injection of poly(I:C) significantly reduced the levels of the proinflammatory mediators tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and IL-15 in the intestinal mucosa.	Poly I-C	61-70	tumor necrosis factor	Mus musculus	166-175
32322251-5	2020	Orally administered MPL16 prior intraperitoneal injection of poly(I:C) significantly reduced the levels of the proinflammatory mediators tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and IL-15 in the intestinal mucosa.	Poly I-C	61-70	interleukin 6	Mus musculus	193-197
32328942-3	2020	In 3 h after combined addition of LPS and Poly I:C in vitro to 12-day-old primary culture of mouse bone marrow stromal cells, the concentration of TNFalpha in culture medium was intermediate between the levels attained by their individual application.	Poly I-C	42-50	tumor necrosis factor	Mus musculus	147-155
32081808-5	2020	On-DDX41 gene was constitutively expressed in all tissues examined, with the highest expression level observed in liver and muscle, and was inducible after poly(I:C) stimulation.	Poly I-C	156-165	probable ATP-dependent RNA helicase DDX41	Oreochromis niloticus	3-8
32273347-7	2020	In vitro-generated CD103+ cDC1s also migrated to TdLNs following poly I:C treatment and intratumoral delivery.	Poly I-C	65-73	integrin alpha E, epithelial-associated	Mus musculus	19-24
32200171-3	2020	Recognition of poly I:C through cytosolic helicase receptors RIG-I and MDA5 molecule lead to the activation of the RLR pathway, subsequently activating the MAVS-IRF3/7 cascade and the production of antiviral effector molecule like IFNbeta and ISGs.	Poly I-C	15-23	mitochondrial antiviral-signaling protein	Bubalus bubalis	156-165
32390869-5	2020	In response to poly(I:C) stimulation, PKCdelta deficient macrophages displayed an increased production of IL-1beta, IL-6, TNF-alpha, and IL-33, which were associated with an enhanced NF-kappaB activation.	Poly I-C	15-24	protein kinase C, delta	Mus musculus	38-46
32390869-5	2020	In response to poly(I:C) stimulation, PKCdelta deficient macrophages displayed an increased production of IL-1beta, IL-6, TNF-alpha, and IL-33, which were associated with an enhanced NF-kappaB activation.	Poly I-C	15-24	interleukin 1 alpha	Mus musculus	106-114
32390869-5	2020	In response to poly(I:C) stimulation, PKCdelta deficient macrophages displayed an increased production of IL-1beta, IL-6, TNF-alpha, and IL-33, which were associated with an enhanced NF-kappaB activation.	Poly I-C	15-24	interleukin 6	Mus musculus	116-120
32390869-5	2020	In response to poly(I:C) stimulation, PKCdelta deficient macrophages displayed an increased production of IL-1beta, IL-6, TNF-alpha, and IL-33, which were associated with an enhanced NF-kappaB activation.	Poly I-C	15-24	tumor necrosis factor	Mus musculus	122-131
32390869-5	2020	In response to poly(I:C) stimulation, PKCdelta deficient macrophages displayed an increased production of IL-1beta, IL-6, TNF-alpha, and IL-33, which were associated with an enhanced NF-kappaB activation.	Poly I-C	15-24	interleukin 33	Mus musculus	137-142
32390869-5	2020	In response to poly(I:C) stimulation, PKCdelta deficient macrophages displayed an increased production of IL-1beta, IL-6, TNF-alpha, and IL-33, which were associated with an enhanced NF-kappaB activation.	Poly I-C	15-24	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	183-192
32328062-7	2020	The oral administration of L. plantarum WT to mice prior the intraperitoneal injection of poly(I:C) significantly increased IFN-beta and IL-10 and reduced intraepithelial lymphocytes (CD3+NK1.1+CD8alphaalpha+) and pro-inflammatory mediators (TNF-alpha, IL-6, and IL-15) in the intestinal mucosa.	Poly I-C	90-99	interferon alpha	Mus musculus	124-132
32328062-7	2020	The oral administration of L. plantarum WT to mice prior the intraperitoneal injection of poly(I:C) significantly increased IFN-beta and IL-10 and reduced intraepithelial lymphocytes (CD3+NK1.1+CD8alphaalpha+) and pro-inflammatory mediators (TNF-alpha, IL-6, and IL-15) in the intestinal mucosa.	Poly I-C	90-99	interleukin 10	Mus musculus	137-142
32328062-7	2020	The oral administration of L. plantarum WT to mice prior the intraperitoneal injection of poly(I:C) significantly increased IFN-beta and IL-10 and reduced intraepithelial lymphocytes (CD3+NK1.1+CD8alphaalpha+) and pro-inflammatory mediators (TNF-alpha, IL-6, and IL-15) in the intestinal mucosa.	Poly I-C	90-99	CD247 antigen	Mus musculus	184-187
32328062-7	2020	The oral administration of L. plantarum WT to mice prior the intraperitoneal injection of poly(I:C) significantly increased IFN-beta and IL-10 and reduced intraepithelial lymphocytes (CD3+NK1.1+CD8alphaalpha+) and pro-inflammatory mediators (TNF-alpha, IL-6, and IL-15) in the intestinal mucosa.	Poly I-C	90-99	killer cell lectin-like receptor subfamily B member 1C	Mus musculus	188-193
32328062-7	2020	The oral administration of L. plantarum WT to mice prior the intraperitoneal injection of poly(I:C) significantly increased IFN-beta and IL-10 and reduced intraepithelial lymphocytes (CD3+NK1.1+CD8alphaalpha+) and pro-inflammatory mediators (TNF-alpha, IL-6, and IL-15) in the intestinal mucosa.	Poly I-C	90-99	tumor necrosis factor	Mus musculus	242-251
32328062-7	2020	The oral administration of L. plantarum WT to mice prior the intraperitoneal injection of poly(I:C) significantly increased IFN-beta and IL-10 and reduced intraepithelial lymphocytes (CD3+NK1.1+CD8alphaalpha+) and pro-inflammatory mediators (TNF-alpha, IL-6, and IL-15) in the intestinal mucosa.	Poly I-C	90-99	interleukin 6	Mus musculus	253-257
32328062-7	2020	The oral administration of L. plantarum WT to mice prior the intraperitoneal injection of poly(I:C) significantly increased IFN-beta and IL-10 and reduced intraepithelial lymphocytes (CD3+NK1.1+CD8alphaalpha+) and pro-inflammatory mediators (TNF-alpha, IL-6, and IL-15) in the intestinal mucosa.	Poly I-C	90-99	interleukin 15	Mus musculus	263-268
32328062-8	2020	Similar to the WT strain, L. plantarumDeltadltD-treated mice showed enhanced levels of IFN-beta after poly(I:C) challenge.	Poly I-C	102-111	interferon alpha	Mus musculus	87-95
32066911-6	2020	Immunisation with the fusion protein plus an immune adjuvant, polyinosinic:polycytidylic acids (poly(I:C)), more potently induced Ag-specific CD8+ T-cell responses through XCR1 than the Ag peptide plus poly(I:C) or the Ag protein plus poly(I:C).	Poly I-C	62-94	chemokine (C motif) receptor 1	Mus musculus	172-176
31559639-0	2020	Polyinosinic-polycytidylic acid accelerates intestinal stem cell proliferation via modulating Myc expression.	Poly I-C	0-31	myelocytomatosis oncogene	Mus musculus	94-97
31559639-8	2020	Mechanistically, poly(I:C) treatment increased expression of Stat1 and Axin2 in the intestinal crypt, which was along with increased expression of Myc, Bcl2, and ISC proliferation.	Poly I-C	17-26	signal transducer and activator of transcription 1	Mus musculus	61-66
31559639-8	2020	Mechanistically, poly(I:C) treatment increased expression of Stat1 and Axin2 in the intestinal crypt, which was along with increased expression of Myc, Bcl2, and ISC proliferation.	Poly I-C	17-26	axin 2	Mus musculus	71-76
31559639-8	2020	Mechanistically, poly(I:C) treatment increased expression of Stat1 and Axin2 in the intestinal crypt, which was along with increased expression of Myc, Bcl2, and ISC proliferation.	Poly I-C	17-26	myelocytomatosis oncogene	Mus musculus	147-150
31559639-8	2020	Mechanistically, poly(I:C) treatment increased expression of Stat1 and Axin2 in the intestinal crypt, which was along with increased expression of Myc, Bcl2, and ISC proliferation.	Poly I-C	17-26	B cell leukemia/lymphoma 2	Mus musculus	152-156
31857701-0	2020	Immunomodulator polyinosinic-polycytidylic acid enhances the inhibitory effect of 13-cis-retinoic acid on neuroblastoma through a TLR3-related immunogenic-apoptotic response.	Poly I-C	16-47	toll like receptor 3	Homo sapiens	130-134
31857701-5	2020	Furthermore, poly (I:C), a synthetic agonist of TLR3, effectively synergized with 13cRA to enhance antiproliferative effects through upregulation of the innate immune signaling and the mitochondrial stress response, leading to augmentation of the apoptotic response in 13cRA-responsive cancer cells.	Poly I-C	13-23	toll like receptor 3	Homo sapiens	48-52
32518871-6	2020	Expression quantitative trait locus (eQTL) analysis in polyinosinic-polycytidylic acid (poly IC)-stimulated renal tubule cells revealed that single nucleotide polymorphism (SNP) rs513349 adjacent to BAK1 was a trans eQTL for APOL1 and a cis eQTL for BAK1; APOL1 and BAK1 were co-expressed in cells.	Poly I-C	88-95	BCL2 antagonist/killer 1	Homo sapiens	250-254
32518871-9	2020	Mitochondria in APOL1 wild-type (G0G0) tubule cells maintained elongated morphology when stimulated by low-dose poly IC, whereas those with G1G1, G2G2, and G1G2 genotypes appeared to fragment.	Poly I-C	112-119	apolipoprotein L1	Homo sapiens	16-21
32518871-6	2020	Expression quantitative trait locus (eQTL) analysis in polyinosinic-polycytidylic acid (poly IC)-stimulated renal tubule cells revealed that single nucleotide polymorphism (SNP) rs513349 adjacent to BAK1 was a trans eQTL for APOL1 and a cis eQTL for BAK1; APOL1 and BAK1 were co-expressed in cells.	Poly I-C	55-86	apolipoprotein L1	Homo sapiens	225-230
32518871-6	2020	Expression quantitative trait locus (eQTL) analysis in polyinosinic-polycytidylic acid (poly IC)-stimulated renal tubule cells revealed that single nucleotide polymorphism (SNP) rs513349 adjacent to BAK1 was a trans eQTL for APOL1 and a cis eQTL for BAK1; APOL1 and BAK1 were co-expressed in cells.	Poly I-C	55-86	BCL2 antagonist/killer 1	Homo sapiens	250-254
32518871-6	2020	Expression quantitative trait locus (eQTL) analysis in polyinosinic-polycytidylic acid (poly IC)-stimulated renal tubule cells revealed that single nucleotide polymorphism (SNP) rs513349 adjacent to BAK1 was a trans eQTL for APOL1 and a cis eQTL for BAK1; APOL1 and BAK1 were co-expressed in cells.	Poly I-C	55-86	apolipoprotein L1	Homo sapiens	256-261
32518871-6	2020	Expression quantitative trait locus (eQTL) analysis in polyinosinic-polycytidylic acid (poly IC)-stimulated renal tubule cells revealed that single nucleotide polymorphism (SNP) rs513349 adjacent to BAK1 was a trans eQTL for APOL1 and a cis eQTL for BAK1; APOL1 and BAK1 were co-expressed in cells.	Poly I-C	55-86	BCL2 antagonist/killer 1	Homo sapiens	250-254
32518871-6	2020	Expression quantitative trait locus (eQTL) analysis in polyinosinic-polycytidylic acid (poly IC)-stimulated renal tubule cells revealed that single nucleotide polymorphism (SNP) rs513349 adjacent to BAK1 was a trans eQTL for APOL1 and a cis eQTL for BAK1; APOL1 and BAK1 were co-expressed in cells.	Poly I-C	88-95	BCL2 antagonist/killer 1	Homo sapiens	199-203
32518871-6	2020	Expression quantitative trait locus (eQTL) analysis in polyinosinic-polycytidylic acid (poly IC)-stimulated renal tubule cells revealed that single nucleotide polymorphism (SNP) rs513349 adjacent to BAK1 was a trans eQTL for APOL1 and a cis eQTL for BAK1; APOL1 and BAK1 were co-expressed in cells.	Poly I-C	88-95	apolipoprotein L1	Homo sapiens	225-230
32518871-6	2020	Expression quantitative trait locus (eQTL) analysis in polyinosinic-polycytidylic acid (poly IC)-stimulated renal tubule cells revealed that single nucleotide polymorphism (SNP) rs513349 adjacent to BAK1 was a trans eQTL for APOL1 and a cis eQTL for BAK1; APOL1 and BAK1 were co-expressed in cells.	Poly I-C	88-95	BCL2 antagonist/killer 1	Homo sapiens	250-254
32518871-6	2020	Expression quantitative trait locus (eQTL) analysis in polyinosinic-polycytidylic acid (poly IC)-stimulated renal tubule cells revealed that single nucleotide polymorphism (SNP) rs513349 adjacent to BAK1 was a trans eQTL for APOL1 and a cis eQTL for BAK1; APOL1 and BAK1 were co-expressed in cells.	Poly I-C	88-95	apolipoprotein L1	Homo sapiens	256-261
32121312-0	2020	Clozapine Prevents Poly (I:C) Induced Inflammation by Modulating NLRP3 Pathway in Microglial Cells.	Poly I-C	19-29	NLR family pyrin domain containing 3	Homo sapiens	65-70
32265633-3	2020	injection of a viral mimetic, polyinosinic-polycytidylic acid (PIC) induces a robust generation of CXCL10 chemokine in the hippocampus.	Poly I-C	30-61	chemokine (C-X-C motif) ligand 10	Mus musculus	99-105
32265633-3	2020	injection of a viral mimetic, polyinosinic-polycytidylic acid (PIC) induces a robust generation of CXCL10 chemokine in the hippocampus.	Poly I-C	63-66	chemokine (C-X-C motif) ligand 10	Mus musculus	99-105
32265633-5	2020	The present study was undertaken to determine the role of CXCL10 in mediating the development of hyperexcitability in response to PIC challenge.	Poly I-C	130-133	chemokine (C-X-C motif) ligand 10	Mus musculus	58-64
32265633-13	2020	Moreover, CXCR3 inhibition attenuated seizure hypersensitivity induced by PIC challenge.	Poly I-C	74-77	chemokine (C-X-C motif) receptor 3	Mus musculus	10-15
32218789-8	2020	Poly I:C increased PD-L1 expression on epithelial cells, lymphocytes, macrophages, and neutrophils in the lungs and IC87114 suppressed poly I:C-induced PD-L1 expression on epithelial cells and neutrophils possibly via inhibition of the Akt/mTOR signaling pathway.	Poly I-C	0-8	CD274 molecule	Homo sapiens	19-24
32218789-8	2020	Poly I:C increased PD-L1 expression on epithelial cells, lymphocytes, macrophages, and neutrophils in the lungs and IC87114 suppressed poly I:C-induced PD-L1 expression on epithelial cells and neutrophils possibly via inhibition of the Akt/mTOR signaling pathway.	Poly I-C	0-8	CD274 molecule	Homo sapiens	152-157
32218789-8	2020	Poly I:C increased PD-L1 expression on epithelial cells, lymphocytes, macrophages, and neutrophils in the lungs and IC87114 suppressed poly I:C-induced PD-L1 expression on epithelial cells and neutrophils possibly via inhibition of the Akt/mTOR signaling pathway.	Poly I-C	0-8	AKT serine/threonine kinase 1	Homo sapiens	236-239
32218789-8	2020	Poly I:C increased PD-L1 expression on epithelial cells, lymphocytes, macrophages, and neutrophils in the lungs and IC87114 suppressed poly I:C-induced PD-L1 expression on epithelial cells and neutrophils possibly via inhibition of the Akt/mTOR signaling pathway.	Poly I-C	0-8	mechanistic target of rapamycin kinase	Homo sapiens	240-244
32218789-8	2020	Poly I:C increased PD-L1 expression on epithelial cells, lymphocytes, macrophages, and neutrophils in the lungs and IC87114 suppressed poly I:C-induced PD-L1 expression on epithelial cells and neutrophils possibly via inhibition of the Akt/mTOR signaling pathway.	Poly I-C	135-143	CD274 molecule	Homo sapiens	152-157
32218789-8	2020	Poly I:C increased PD-L1 expression on epithelial cells, lymphocytes, macrophages, and neutrophils in the lungs and IC87114 suppressed poly I:C-induced PD-L1 expression on epithelial cells and neutrophils possibly via inhibition of the Akt/mTOR signaling pathway.	Poly I-C	135-143	AKT serine/threonine kinase 1	Homo sapiens	236-239
32218789-8	2020	Poly I:C increased PD-L1 expression on epithelial cells, lymphocytes, macrophages, and neutrophils in the lungs and IC87114 suppressed poly I:C-induced PD-L1 expression on epithelial cells and neutrophils possibly via inhibition of the Akt/mTOR signaling pathway.	Poly I-C	135-143	mechanistic target of rapamycin kinase	Homo sapiens	240-244
32218789-14	2020	IC87114 further enhanced poly I:C- induced increases in the concentrations of IFNbeta and IFNlambda1/3 in culture supernatants as well as upregulated gene expression of ISGs in PBECs.	Poly I-C	25-33	interferon alpha 1	Homo sapiens	78-102
31816635-4	2020	Mice lacking NFAT5 exhibit increased IFN-I production and better control of viral burden upon LCMV infection but show exacerbated HSC activation under systemic poly(I:C)-induced inflammation.	Poly I-C	160-169	nuclear factor of activated T cells 5	Mus musculus	13-18
32699842-4	2020	Here we investigate the intentional ligation of the pattern recognition receptor Toll-like receptor 3 (TLR3) by polyinosinic-polycytidylic acid (poly I:C) for its ability to prevent or control infection and associated cognitive disease in EcoHIV infected mice.	Poly I-C	112-143	toll-like receptor 3	Mus musculus	81-101
32699842-4	2020	Here we investigate the intentional ligation of the pattern recognition receptor Toll-like receptor 3 (TLR3) by polyinosinic-polycytidylic acid (poly I:C) for its ability to prevent or control infection and associated cognitive disease in EcoHIV infected mice.	Poly I-C	112-143	toll-like receptor 3	Mus musculus	103-107
32699842-4	2020	Here we investigate the intentional ligation of the pattern recognition receptor Toll-like receptor 3 (TLR3) by polyinosinic-polycytidylic acid (poly I:C) for its ability to prevent or control infection and associated cognitive disease in EcoHIV infected mice.	Poly I-C	145-153	toll-like receptor 3	Mus musculus	81-101
32699842-4	2020	Here we investigate the intentional ligation of the pattern recognition receptor Toll-like receptor 3 (TLR3) by polyinosinic-polycytidylic acid (poly I:C) for its ability to prevent or control infection and associated cognitive disease in EcoHIV infected mice.	Poly I-C	145-153	toll-like receptor 3	Mus musculus	103-107
31486084-0	2020	CARD14/CARMA2sh and TANK differentially regulate poly(I:C)-induced inflammatory reaction in keratinocytes.	Poly I-C	49-58	caspase recruitment domain family member 14	Homo sapiens	0-6
31486084-0	2020	CARD14/CARMA2sh and TANK differentially regulate poly(I:C)-induced inflammatory reaction in keratinocytes.	Poly I-C	49-58	caspase recruitment domain family member 14	Homo sapiens	7-13
31486084-3	2020	We also show that CARMA2 and TANK are individually required to activate the nuclear factor kappaB (NF-kappaB) response following exposure to polyinosinic-polycytidylic (poly [I:C]), an agonist of toll-like receptor 3.	Poly I-C	169-179	caspase recruitment domain family member 14	Homo sapiens	18-24
31486084-3	2020	We also show that CARMA2 and TANK are individually required to activate the nuclear factor kappaB (NF-kappaB) response following exposure to polyinosinic-polycytidylic (poly [I:C]), an agonist of toll-like receptor 3.	Poly I-C	169-179	nuclear factor kappa B subunit 1	Homo sapiens	99-108
31486084-3	2020	We also show that CARMA2 and TANK are individually required to activate the nuclear factor kappaB (NF-kappaB) response following exposure to polyinosinic-polycytidylic (poly [I:C]), an agonist of toll-like receptor 3.	Poly I-C	169-179	toll like receptor 3	Homo sapiens	196-216
31486084-4	2020	Finally, we present data indicating that TANK is essential for activation of the TBK1/IRF3 pathway following poly (I:C) stimulation, whereas CARMA2sh functions as a repressor of it.	Poly I-C	109-119	TANK binding kinase 1	Homo sapiens	81-85
31486084-4	2020	Finally, we present data indicating that TANK is essential for activation of the TBK1/IRF3 pathway following poly (I:C) stimulation, whereas CARMA2sh functions as a repressor of it.	Poly I-C	109-119	interferon regulatory factor 3	Homo sapiens	86-90
32121312-10	2020	Clozapine reduced the level of poly (I:C)-activated NLRP3 expression by 57%, which was higher than the reduction thay was seen with CRID3 treatment (45%).	Poly I-C	31-41	NLR family pyrin domain containing 3	Homo sapiens	52-57
32218789-0	2020	Inhibition of PI3Kdelta Enhances Poly I:C-Induced Antiviral Responses and Inhibits Replication of Human Metapneumovirus in Murine Lungs and Human Bronchial Epithelial Cells.	Poly I-C	33-41	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	14-23
32218789-4	2020	Using a synthetic double-stranded RNA poly I:C and a selective PI3Kdelta inhibitor IC87114, we investigated the role of PI3Kdelta signaling in poly I:C-induced expression of the T lymphocyte-inhibitory molecule programmed death 1 ligand 1 (PD-L1), inflammatory responses and antiviral interferon (IFN) responses.	Poly I-C	143-151	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	63-72
32218789-4	2020	Using a synthetic double-stranded RNA poly I:C and a selective PI3Kdelta inhibitor IC87114, we investigated the role of PI3Kdelta signaling in poly I:C-induced expression of the T lymphocyte-inhibitory molecule programmed death 1 ligand 1 (PD-L1), inflammatory responses and antiviral interferon (IFN) responses.	Poly I-C	143-151	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	120-129
32218789-4	2020	Using a synthetic double-stranded RNA poly I:C and a selective PI3Kdelta inhibitor IC87114, we investigated the role of PI3Kdelta signaling in poly I:C-induced expression of the T lymphocyte-inhibitory molecule programmed death 1 ligand 1 (PD-L1), inflammatory responses and antiviral interferon (IFN) responses.	Poly I-C	143-151	CD274 molecule	Homo sapiens	211-238
32218789-4	2020	Using a synthetic double-stranded RNA poly I:C and a selective PI3Kdelta inhibitor IC87114, we investigated the role of PI3Kdelta signaling in poly I:C-induced expression of the T lymphocyte-inhibitory molecule programmed death 1 ligand 1 (PD-L1), inflammatory responses and antiviral interferon (IFN) responses.	Poly I-C	143-151	CD274 molecule	Homo sapiens	240-245
32218789-4	2020	Using a synthetic double-stranded RNA poly I:C and a selective PI3Kdelta inhibitor IC87114, we investigated the role of PI3Kdelta signaling in poly I:C-induced expression of the T lymphocyte-inhibitory molecule programmed death 1 ligand 1 (PD-L1), inflammatory responses and antiviral interferon (IFN) responses.	Poly I-C	143-151	interferon alpha 1	Homo sapiens	285-301
31838086-4	2020	Activation of TLR3 by Poly(I:C) induced apoptosis of 4/8 TLR3-positive cell lines but not of TLR3-negative cell lines.	Poly I-C	22-31	toll like receptor 3	Homo sapiens	14-18
31838086-4	2020	Activation of TLR3 by Poly(I:C) induced apoptosis of 4/8 TLR3-positive cell lines but not of TLR3-negative cell lines.	Poly I-C	22-31	toll like receptor 3	Homo sapiens	57-61
31838086-4	2020	Activation of TLR3 by Poly(I:C) induced apoptosis of 4/8 TLR3-positive cell lines but not of TLR3-negative cell lines.	Poly I-C	22-31	toll like receptor 3	Homo sapiens	57-61
32037657-2	2020	Here, we found that PRRSV infection upregulated the expression of miR-382-5p, which in turn inhibited polyI:C-induced the production of type I interferon by targeting heat shock protein 60 (HSP60), thus facilitating PRRSV replication in MARC-145 cells.	Poly I-C	102-109	microRNA 382	Homo sapiens	66-73
32037657-2	2020	Here, we found that PRRSV infection upregulated the expression of miR-382-5p, which in turn inhibited polyI:C-induced the production of type I interferon by targeting heat shock protein 60 (HSP60), thus facilitating PRRSV replication in MARC-145 cells.	Poly I-C	102-109	heat shock protein family D (Hsp60) member 1	Homo sapiens	190-195
32037657-3	2020	Furthermore, we found that HSP60 could interact with mitochondrial antiviral signaling protein (MAVS), an important signal transduction protein for inducing production of type I interferon, and promote polyI:C-mediated the production of type I interferon in a MAVS-dependent manner.	Poly I-C	202-209	heat shock protein family D (Hsp60) member 1	Homo sapiens	27-32
32037657-3	2020	Furthermore, we found that HSP60 could interact with mitochondrial antiviral signaling protein (MAVS), an important signal transduction protein for inducing production of type I interferon, and promote polyI:C-mediated the production of type I interferon in a MAVS-dependent manner.	Poly I-C	202-209	mitochondrial antiviral signaling protein	Homo sapiens	53-94
32037657-3	2020	Furthermore, we found that HSP60 could interact with mitochondrial antiviral signaling protein (MAVS), an important signal transduction protein for inducing production of type I interferon, and promote polyI:C-mediated the production of type I interferon in a MAVS-dependent manner.	Poly I-C	202-209	mitochondrial antiviral signaling protein	Homo sapiens	96-100
32037657-3	2020	Furthermore, we found that HSP60 could interact with mitochondrial antiviral signaling protein (MAVS), an important signal transduction protein for inducing production of type I interferon, and promote polyI:C-mediated the production of type I interferon in a MAVS-dependent manner.	Poly I-C	202-209	mitochondrial antiviral signaling protein	Homo sapiens	260-264
32009132-10	2020	Poly(I:C) induced remarkable TGF-beta1, CH3L1, Th2 cytokine, and OPN levels in BALF and the expression of phosphorylated Smad3, TGM2, and Spp1 in the lungs.	Poly I-C	0-9	transforming growth factor, beta 1	Mus musculus	29-38
32132922-8	2020	APN inhibited the poly(I:C)-induced production of these five cytokines and the TNF-alpha-induced production of CCL2 and CXCL1.	Poly I-C	18-27	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-3
32033247-4	2020	In this study, we explored the molecular mechanism of 8-HD in regulating inflammatory processes, with a focus on the IRF-3 signaling pathway using a lipopolysaccharide (LPS) and polyinosinic:polycytidylic acid [Poly (I:C)] stimulated murine macrophage cell line (RAW264.7).	Poly I-C	178-209	interferon regulatory factor 3	Mus musculus	117-122
32185237-0	2020	The Response of Tissue Mast Cells to TLR3 Ligand Poly(I:C) Treatment.	Poly I-C	49-58	toll-like receptor 3	Rattus norvegicus	37-41
31629806-3	2020	Modulation of basal level and poly(I:C)-induced IL-8 secretion varied between bacterial species, and between heat treated and non-heat treated bacterial cells.	Poly I-C	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
32009132-10	2020	Poly(I:C) induced remarkable TGF-beta1, CH3L1, Th2 cytokine, and OPN levels in BALF and the expression of phosphorylated Smad3, TGM2, and Spp1 in the lungs.	Poly I-C	0-9	chitinase 3 like 1	Homo sapiens	40-45
32009132-10	2020	Poly(I:C) induced remarkable TGF-beta1, CH3L1, Th2 cytokine, and OPN levels in BALF and the expression of phosphorylated Smad3, TGM2, and Spp1 in the lungs.	Poly I-C	0-9	secreted phosphoprotein 1	Mus musculus	65-68
32009132-10	2020	Poly(I:C) induced remarkable TGF-beta1, CH3L1, Th2 cytokine, and OPN levels in BALF and the expression of phosphorylated Smad3, TGM2, and Spp1 in the lungs.	Poly I-C	0-9	SMAD family member 3	Homo sapiens	121-126
32009132-10	2020	Poly(I:C) induced remarkable TGF-beta1, CH3L1, Th2 cytokine, and OPN levels in BALF and the expression of phosphorylated Smad3, TGM2, and Spp1 in the lungs.	Poly I-C	0-9	transglutaminase 2	Homo sapiens	128-132
32009132-10	2020	Poly(I:C) induced remarkable TGF-beta1, CH3L1, Th2 cytokine, and OPN levels in BALF and the expression of phosphorylated Smad3, TGM2, and Spp1 in the lungs.	Poly I-C	0-9	secreted phosphoprotein 1	Mus musculus	138-142
32211095-7	2020	Consistently, poly (I:C)-induced retarded growth was reversed by TLR3 silencing, which was especially enhanced in LMP1-overexpressed cells.	Poly I-C	14-24	toll like receptor 3	Homo sapiens	65-69
32211095-7	2020	Consistently, poly (I:C)-induced retarded growth was reversed by TLR3 silencing, which was especially enhanced in LMP1-overexpressed cells.	Poly I-C	14-24	PDZ and LIM domain 7	Homo sapiens	114-118
31952519-11	2020	Poly(I:C)-mediated protection correlated with an augmented number of NK cells (CD45+NK1.1+CD3-) and Iba-1+ microglial cells and a higher production of IFN-gamma in the brain.	Poly I-C	0-9	allograft inflammatory factor 1	Homo sapiens	100-105
31943744-0	2020	IL-6 expression promoted by Poly(I:C) in cervical cancer cells regulates cytokine expression and recruitment of macrophages.	Poly I-C	28-37	interleukin 6	Homo sapiens	0-4
31711888-10	2020	Poly(I:C) induced a higher expression of the maturation markers CD80, CD86 and CD40 compared to LPS.	Poly I-C	0-9	CD80 molecule	Homo sapiens	64-68
31711888-10	2020	Poly(I:C) induced a higher expression of the maturation markers CD80, CD86 and CD40 compared to LPS.	Poly I-C	0-9	CD86 molecule	Homo sapiens	70-74
31711888-10	2020	Poly(I:C) induced a higher expression of the maturation markers CD80, CD86 and CD40 compared to LPS.	Poly I-C	0-9	CD40 molecule	Homo sapiens	79-83
31711888-12	2020	Additionally, we demonstrated a higher release of IFN-gamma, TNF-alpha, IL-1beta and IL-6, but lower release of IL-10 in Poly(I:C) matured compared to LPS matured neonatal DCs derived from cord blood CD34+ hematopoietic stem cells.	Poly I-C	121-130	interleukin 10	Homo sapiens	112-117
31952519-11	2020	Poly(I:C)-mediated protection correlated with an augmented number of NK cells (CD45+NK1.1+CD3-) and Iba-1+ microglial cells and a higher production of IFN-gamma in the brain.	Poly I-C	0-9	interferon gamma	Homo sapiens	151-160
31951181-2	2020	Previously, we demonstrated that the anticancer activity of the RLR agonist Poly(I:C)-HMW/LyoVec  [Poly(I:C)-HMW] against human lung cancer cells was enhanced by cotreatment with ionizing radiation (IR).	Poly I-C	76-85	cilia and flagella associated protein 97	Homo sapiens	86-89
31953424-4	2020	Our findings revealed that in slice cultures only upon demyelination, the TLR3 agonist Poly(I:C) evoked astrocytes to form fibronectin aggregates.	Poly I-C	87-96	toll like receptor 3	Homo sapiens	74-78
31953424-4	2020	Our findings revealed that in slice cultures only upon demyelination, the TLR3 agonist Poly(I:C) evoked astrocytes to form fibronectin aggregates.	Poly I-C	87-96	fibronectin 1	Homo sapiens	123-134
31953424-5	2020	Consistently, pro-inflammatory cytokine-pretreated astrocytes were more susceptible to Poly(I:C)-induced fibronectin aggregation, indicating that astrocytes form fibronectin aggregates upon a double hit by inflammatory mediators.	Poly I-C	87-96	fibronectin 1	Homo sapiens	105-116
31953424-5	2020	Consistently, pro-inflammatory cytokine-pretreated astrocytes were more susceptible to Poly(I:C)-induced fibronectin aggregation, indicating that astrocytes form fibronectin aggregates upon a double hit by inflammatory mediators.	Poly I-C	87-96	fibronectin 1	Homo sapiens	162-173
31953424-6	2020	The underlying mechanism involves disrupted fibronectin fibrillogenesis at the cell surface as a result of a cytokine-induced increase in relative mRNA levels of EIIIApos-Fn over EIIIBpos-Fn and a Poly(I:C)-mediated decrease in integrin affinity.	Poly I-C	197-206	fibronectin 1	Homo sapiens	44-55
31951181-2	2020	Previously, we demonstrated that the anticancer activity of the RLR agonist Poly(I:C)-HMW/LyoVec  [Poly(I:C)-HMW] against human lung cancer cells was enhanced by cotreatment with ionizing radiation (IR).	Poly I-C	76-85	cilia and flagella associated protein 97	Homo sapiens	109-112
31951181-3	2020	In addition, cotreatment with Poly(I:C)-HMW and IR induced apoptosis in a Fas-independent manner, and increased Fas expression on the cell surface.	Poly I-C	30-39	cilia and flagella associated protein 97	Homo sapiens	40-43
31951181-9	2020	CONCLUSION: In summary, the present study indicated that upregulated Fas expression following cotreatment with Poly(I:C)-HMW and IR was responsive to FasL-induced apoptosis, and combination of RLR agonist, IR, and FasL could be a potential promising cancer therapy.	Poly I-C	111-120	cilia and flagella associated protein 97	Homo sapiens	121-124
31951181-9	2020	CONCLUSION: In summary, the present study indicated that upregulated Fas expression following cotreatment with Poly(I:C)-HMW and IR was responsive to FasL-induced apoptosis, and combination of RLR agonist, IR, and FasL could be a potential promising cancer therapy.	Poly I-C	111-120	Fas ligand	Homo sapiens	150-154
31951181-9	2020	CONCLUSION: In summary, the present study indicated that upregulated Fas expression following cotreatment with Poly(I:C)-HMW and IR was responsive to FasL-induced apoptosis, and combination of RLR agonist, IR, and FasL could be a potential promising cancer therapy.	Poly I-C	111-120	Fas ligand	Homo sapiens	214-218
31676429-5	2020	However, we found that upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid [poly (I:C)], CgMyD88-1 and CgMyD88-2 show differences in their response: CgMyD88-1 accumulated as large spots in the cytoplasm, while CgMyD88-2 assembled in the cytoplasm and in the membrane.	Poly I-C	106-116	myeloid differentiation primary response protein MyD88-like	Crassostrea gigas	133-142
31820024-10	2020	Concentrations of IL-6, RANTES, and MIP-2 induced by HDM and poly(I:C) were significantly suppressed by EM900 through the suppression of NF-kappaB and p38 phosphorylation in macrophages.	Poly I-C	61-70	interleukin 6	Mus musculus	18-22
31820024-10	2020	Concentrations of IL-6, RANTES, and MIP-2 induced by HDM and poly(I:C) were significantly suppressed by EM900 through the suppression of NF-kappaB and p38 phosphorylation in macrophages.	Poly I-C	61-70	chemokine (C-C motif) ligand 5	Mus musculus	24-30
31820024-10	2020	Concentrations of IL-6, RANTES, and MIP-2 induced by HDM and poly(I:C) were significantly suppressed by EM900 through the suppression of NF-kappaB and p38 phosphorylation in macrophages.	Poly I-C	61-70	chemokine (C-X-C motif) ligand 2	Mus musculus	36-41
31820024-10	2020	Concentrations of IL-6, RANTES, and MIP-2 induced by HDM and poly(I:C) were significantly suppressed by EM900 through the suppression of NF-kappaB and p38 phosphorylation in macrophages.	Poly I-C	61-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	137-146
31820024-10	2020	Concentrations of IL-6, RANTES, and MIP-2 induced by HDM and poly(I:C) were significantly suppressed by EM900 through the suppression of NF-kappaB and p38 phosphorylation in macrophages.	Poly I-C	61-70	mitogen-activated protein kinase 14	Mus musculus	151-154
32294654-0	2020	Polyinosinic-Polycytidylic Acid Induces CXCL1 Expression in Cultured hCMEC/D3 Human Cerebral Microvascular Endothelial Cells.	Poly I-C	0-31	C-X-C motif chemokine ligand 1	Homo sapiens	40-45
31330219-12	2020	IL-37b suppressed polyinosinic-polycytidylic acid-induced TSLP production in HNECs in vitro and in murine nasal epithelial cells in vivo.	Poly I-C	18-49	thymic stromal lymphopoietin	Mus musculus	58-62
32363951-7	2020	The aim of this study was to examine the expression of ISG56 and its role in CXCL10 production in BEAS-2B bronchial epithelial cells treated with dsRNA.Materials and methods: BEAS-2B bronchial epithelial cells were treated with polyinosinic-polycytidylic acid (poly IC), a synthetic TLR3 ligand.	Poly I-C	228-259	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	55-60
32363951-7	2020	The aim of this study was to examine the expression of ISG56 and its role in CXCL10 production in BEAS-2B bronchial epithelial cells treated with dsRNA.Materials and methods: BEAS-2B bronchial epithelial cells were treated with polyinosinic-polycytidylic acid (poly IC), a synthetic TLR3 ligand.	Poly I-C	261-268	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	55-60
32363951-10	2020	The protein expression of CXCL10 in culture medium was measured using an enzyme-linked immunosorbent assay.Results: Poly IC induced ISG56 expression in a concentration- and time- dependent manner.	Poly I-C	116-123	C-X-C motif chemokine ligand 10	Homo sapiens	26-32
32363951-10	2020	The protein expression of CXCL10 in culture medium was measured using an enzyme-linked immunosorbent assay.Results: Poly IC induced ISG56 expression in a concentration- and time- dependent manner.	Poly I-C	116-123	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	132-137
32294654-6	2020	METHODS: hCMEC/D3 human cerebral microvascular endothelial cells were cultured and treated with polyinosinic-polycytidylic acid (poly IC), a potent synthetic dsRNA agonist for TLR3.	Poly I-C	96-127	toll like receptor 3	Homo sapiens	176-180
32294654-6	2020	METHODS: hCMEC/D3 human cerebral microvascular endothelial cells were cultured and treated with polyinosinic-polycytidylic acid (poly IC), a potent synthetic dsRNA agonist for TLR3.	Poly I-C	129-136	toll like receptor 3	Homo sapiens	176-180
32294654-11	2020	RESULTS: Treating cultured hCMEC/D3 human cells with poly IC induced the expression of CXCL1 as well as another chemokine CXCL8.	Poly I-C	53-60	C-X-C motif chemokine ligand 1	Homo sapiens	87-92
32294654-11	2020	RESULTS: Treating cultured hCMEC/D3 human cells with poly IC induced the expression of CXCL1 as well as another chemokine CXCL8.	Poly I-C	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	122-127
32294654-12	2020	Pretreatment of cells with SN50, SB203580, and SP600125 decreased the induction of CXCL1 by poly IC.	Poly I-C	92-99	C-X-C motif chemokine ligand 1	Homo sapiens	83-88
32294654-14	2020	Pretreatment of cells with SN50 decreased the poly IC-induced phosphorylation of p38.	Poly I-C	46-53	mitogen-activated protein kinase 14	Homo sapiens	81-84
31892731-1	2019	Toll-like receptor 3 (TLR3) recognizes double-stranded RNA derived from virus and its synthetic analogue, polyinosinic-polycytidylic acid [poly(I:C)].	Poly I-C	106-137	toll-like receptor 3	Mus musculus	0-20
31892731-1	2019	Toll-like receptor 3 (TLR3) recognizes double-stranded RNA derived from virus and its synthetic analogue, polyinosinic-polycytidylic acid [poly(I:C)].	Poly I-C	106-137	toll-like receptor 3	Mus musculus	22-26
31520792-0	2019	Interferon-induced transmembrane protein 1 and Myxovirus resistance protein 1 are induced by polyinosinic-polycytidylic acid in cultured hCMEC/D3 human cerebral microvascular endothelial cells.	Poly I-C	93-124	interferon induced transmembrane protein 1	Homo sapiens	0-42
31520792-4	2019	Here we observed that IFITM1 and MX1, and a proinflammatory cytokine IL-6 expression was induced by polyinosinic-polycytidylic acid (poly IC) in hCMEC/D3 human brain microvascular endothelial cells.	Poly I-C	100-131	interferon induced transmembrane protein 1	Homo sapiens	22-28
31520792-4	2019	Here we observed that IFITM1 and MX1, and a proinflammatory cytokine IL-6 expression was induced by polyinosinic-polycytidylic acid (poly IC) in hCMEC/D3 human brain microvascular endothelial cells.	Poly I-C	100-131	MX dynamin like GTPase 1	Homo sapiens	33-36
31520792-4	2019	Here we observed that IFITM1 and MX1, and a proinflammatory cytokine IL-6 expression was induced by polyinosinic-polycytidylic acid (poly IC) in hCMEC/D3 human brain microvascular endothelial cells.	Poly I-C	100-131	interleukin 6	Homo sapiens	69-73
31520792-4	2019	Here we observed that IFITM1 and MX1, and a proinflammatory cytokine IL-6 expression was induced by polyinosinic-polycytidylic acid (poly IC) in hCMEC/D3 human brain microvascular endothelial cells.	Poly I-C	133-140	interferon induced transmembrane protein 1	Homo sapiens	22-28
31520792-4	2019	Here we observed that IFITM1 and MX1, and a proinflammatory cytokine IL-6 expression was induced by polyinosinic-polycytidylic acid (poly IC) in hCMEC/D3 human brain microvascular endothelial cells.	Poly I-C	133-140	MX dynamin like GTPase 1	Homo sapiens	33-36
31520792-4	2019	Here we observed that IFITM1 and MX1, and a proinflammatory cytokine IL-6 expression was induced by polyinosinic-polycytidylic acid (poly IC) in hCMEC/D3 human brain microvascular endothelial cells.	Poly I-C	133-140	interleukin 6	Homo sapiens	69-73
31672626-7	2019	Importantly, covalently SLP-loaded nanogels adjuvanted with poly(I:C) showed superior CD8+ T cell responses compared to soluble peptides and nanogel formulations with physically loaded peptides both in vitro and in vivo.	Poly I-C	60-69	CD8a molecule	Homo sapiens	86-89
31615841-3	2019	Poly(I:C) is a synthetic dsRNA analog and increases the expression of octamer-binding protein 3/4 (OCT3/4), NANOG, and SRY-box (SOX) mRNAs during pluripotency induction.	Poly I-C	0-9	POU class 5 homeobox 1	Homo sapiens	70-97
31615841-3	2019	Poly(I:C) is a synthetic dsRNA analog and increases the expression of octamer-binding protein 3/4 (OCT3/4), NANOG, and SRY-box (SOX) mRNAs during pluripotency induction.	Poly I-C	0-9	POU class 5 homeobox 1	Homo sapiens	99-105
31615841-3	2019	Poly(I:C) is a synthetic dsRNA analog and increases the expression of octamer-binding protein 3/4 (OCT3/4), NANOG, and SRY-box (SOX) mRNAs during pluripotency induction.	Poly I-C	0-9	Nanog homeobox	Homo sapiens	108-113
30997942-5	2019	In this study, polyinosinic polycytidylic acid (polyI:C) was used as an activator of TLR3.	Poly I-C	15-46	toll-like receptor 3	Mus musculus	85-89
31480179-5	2019	In addition, the time- and dose-dependent expression of chLECT2 was examined in DF-1 cells which were stimulated with polyinosinic:polycytidylic acid (poly (I:C)), a TLR3 ligand.	Poly I-C	118-149	toll like receptor 3	Gallus gallus	166-170
31619538-4	2019	GSK3beta deficiency in mouse embryonic fibroblasts significantly reduces polyinosinic:polycytidylic acid-induced IFN-beta and IFN-stimulated gene expression, which is caused by diminished phosphorylation of Src at tyrosine 416.	Poly I-C	73-104	glycogen synthase kinase 3 beta	Mus musculus	0-8
31619538-4	2019	GSK3beta deficiency in mouse embryonic fibroblasts significantly reduces polyinosinic:polycytidylic acid-induced IFN-beta and IFN-stimulated gene expression, which is caused by diminished phosphorylation of Src at tyrosine 416.	Poly I-C	73-104	interferon beta 1, fibroblast	Mus musculus	113-121
31619538-4	2019	GSK3beta deficiency in mouse embryonic fibroblasts significantly reduces polyinosinic:polycytidylic acid-induced IFN-beta and IFN-stimulated gene expression, which is caused by diminished phosphorylation of Src at tyrosine 416.	Poly I-C	73-104	Rous sarcoma oncogene	Mus musculus	207-210
31619538-5	2019	Src undergoes polyinosinic:polycytidylic acid-dependent lysine 63 chain ubiquitination, and TRAF2 is a direct E3 ligase for Src.	Poly I-C	14-45	Rous sarcoma oncogene	Mus musculus	0-3
33911660-10	2019	Meanwhile, lipids reversed the inhibition of poly (I:C) on FLG.	Poly I-C	45-55	filaggrin	Homo sapiens	59-62
33911660-11	2019	Moreover, lipids suppressed the over secretion of TSLP and TNF-alpha induced by poly (I:C).	Poly I-C	80-90	thymic stromal lymphopoietin	Homo sapiens	50-54
33911660-11	2019	Moreover, lipids suppressed the over secretion of TSLP and TNF-alpha induced by poly (I:C).	Poly I-C	80-90	tumor necrosis factor	Homo sapiens	59-68
31637474-4	2019	Local treatment prior to DaRT, with the TLR3 agonist poly I:C, was sufficient to inhibit tumor growth relative to poly I:C or DaRT alone.	Poly I-C	53-61	toll-like receptor 3	Mus musculus	40-44
31637474-4	2019	Local treatment prior to DaRT, with the TLR3 agonist poly I:C, was sufficient to inhibit tumor growth relative to poly I:C or DaRT alone.	Poly I-C	114-122	toll-like receptor 3	Mus musculus	40-44
31776046-7	2019	Pull-down assay showed that Poly(I:C) increased the GTP-binding RHOA and CDC42, suggesting TLR3 stimulation activated RHOA and CDC42.	Poly I-C	28-37	ras homolog family member A	Homo sapiens	64-68
31776046-7	2019	Pull-down assay showed that Poly(I:C) increased the GTP-binding RHOA and CDC42, suggesting TLR3 stimulation activated RHOA and CDC42.	Poly I-C	28-37	cell division cycle 42	Homo sapiens	73-78
31776046-7	2019	Pull-down assay showed that Poly(I:C) increased the GTP-binding RHOA and CDC42, suggesting TLR3 stimulation activated RHOA and CDC42.	Poly I-C	28-37	toll like receptor 3	Homo sapiens	91-95
31776046-7	2019	Pull-down assay showed that Poly(I:C) increased the GTP-binding RHOA and CDC42, suggesting TLR3 stimulation activated RHOA and CDC42.	Poly I-C	28-37	ras homolog family member A	Homo sapiens	118-122
31776046-7	2019	Pull-down assay showed that Poly(I:C) increased the GTP-binding RHOA and CDC42, suggesting TLR3 stimulation activated RHOA and CDC42.	Poly I-C	28-37	cell division cycle 42	Homo sapiens	127-132
31776046-9	2019	Consistently, the knockdown of RHOA and CDC42 significantly suppressed the melanosome-rich globules uptake by Poly(I:C)-stimulated keratinocytes.	Poly I-C	110-119	ras homolog family member A	Homo sapiens	31-35
31776046-9	2019	Consistently, the knockdown of RHOA and CDC42 significantly suppressed the melanosome-rich globules uptake by Poly(I:C)-stimulated keratinocytes.	Poly I-C	110-119	cell division cycle 42	Homo sapiens	40-45
31771091-11	2019	LL37 is known to bind poly I:C where it is thought to compete for receptor binding on the surface of some immune cells, metastatic melanoma and lung cells.	Poly I-C	22-30	cathelicidin antimicrobial peptide	Homo sapiens	0-4
31520463-6	2019	Stimulation of OECs with poly(I:C) led to selective induction of ISGs, including MX1, BST2, PML, RSAD2, ISG15, and ZC3HAV1.	Poly I-C	25-34	MX dynamin like GTPase 1	Homo sapiens	81-84
31520463-6	2019	Stimulation of OECs with poly(I:C) led to selective induction of ISGs, including MX1, BST2, PML, RSAD2, ISG15, and ZC3HAV1.	Poly I-C	25-34	bone marrow stromal cell antigen 2	Homo sapiens	86-90
31520463-6	2019	Stimulation of OECs with poly(I:C) led to selective induction of ISGs, including MX1, BST2, PML, RSAD2, ISG15, and ZC3HAV1.	Poly I-C	25-34	PML nuclear body scaffold	Homo sapiens	92-95
31520463-6	2019	Stimulation of OECs with poly(I:C) led to selective induction of ISGs, including MX1, BST2, PML, RSAD2, ISG15, and ZC3HAV1.	Poly I-C	25-34	radical S-adenosyl methionine domain containing 2	Homo sapiens	97-102
31520463-6	2019	Stimulation of OECs with poly(I:C) led to selective induction of ISGs, including MX1, BST2, PML, RSAD2, ISG15, and ZC3HAV1.	Poly I-C	25-34	ISG15 ubiquitin like modifier	Homo sapiens	104-109
31520463-6	2019	Stimulation of OECs with poly(I:C) led to selective induction of ISGs, including MX1, BST2, PML, RSAD2, ISG15, and ZC3HAV1.	Poly I-C	25-34	zinc finger CCCH-type containing, antiviral 1	Homo sapiens	115-122
31154625-13	2019	Graphical Abstract Involvement of IRF7 in nicotine"s suppression of poly I:C-induced antiviral immune responses.	Poly I-C	68-76	interferon regulatory factor 7	Homo sapiens	34-38
31254564-5	2019	The delay in the induction of EAPP mRNA level up-regulation following poly(I:C) stimulation coincided with a delay in ifn1 transcript levels and secretion, which is important since interferon-stimulated response elements were identified in the promoter regions of the EAPP-specific members of the pathway, implying that IFN1 is involved in the regulation of these genes.	Poly I-C	70-79	interferon a3	Oncorhynchus mykiss	118-122
31254564-5	2019	The delay in the induction of EAPP mRNA level up-regulation following poly(I:C) stimulation coincided with a delay in ifn1 transcript levels and secretion, which is important since interferon-stimulated response elements were identified in the promoter regions of the EAPP-specific members of the pathway, implying that IFN1 is involved in the regulation of these genes.	Poly I-C	70-79	eapp	None	30-34
31254564-5	2019	The delay in the induction of EAPP mRNA level up-regulation following poly(I:C) stimulation coincided with a delay in ifn1 transcript levels and secretion, which is important since interferon-stimulated response elements were identified in the promoter regions of the EAPP-specific members of the pathway, implying that IFN1 is involved in the regulation of these genes.	Poly I-C	70-79	interferon a3	Oncorhynchus mykiss	320-324
31505962-10	2019	When we overexpressed IRF8 in our WT cells we noticed inhibition of poly I:C responses.	Poly I-C	68-76	interferon regulatory factor 8	Homo sapiens	22-26
31720044-9	2019	However, viperin upregulates expression of these ISGs in both BMDMs and MEFs stimulated with polyinosinic-polycytidylic acid or CpG DNA and infected with murine CMV.	Poly I-C	93-124	radical S-adenosyl methionine domain containing 2	Mus musculus	9-16
31336144-6	2019	IFN-beta reproduced the inhibitory effects of Poly I:C on neuronal excitability in hippocampal slices.	Poly I-C	46-54	interferon beta 1, fibroblast	Mus musculus	0-8
31326586-12	2019	Furthermore, overexpression of ToIRF2 in vitro obviously increased the expression of several IFN/IRF-based signalling pathway genes after poly (I:C) abduction.	Poly I-C	138-148	interferon alpha 1	Homo sapiens	93-96
31326586-12	2019	Furthermore, overexpression of ToIRF2 in vitro obviously increased the expression of several IFN/IRF-based signalling pathway genes after poly (I:C) abduction.	Poly I-C	138-148	tripartite motif containing 63	Homo sapiens	33-36
31044626-10	2019	Furthermore, the capacity of ILT4+CD1c+ subset producing IFN-gamma was lower than ILT4- CD1c subset in PBMC of HCC patients following Poly I:C stimulation.	Poly I-C	134-142	leukocyte immunoglobulin like receptor B2	Homo sapiens	29-33
31546038-8	2019	Intraperitoneal injection of poly(I:C) resulted in up-regulation of most S100 genes in the gut and spleen, with highest induction of S100V2 and S100Z detected.	Poly I-C	29-38	S100 calcium binding protein B	Homo sapiens	73-77
31546038-8	2019	Intraperitoneal injection of poly(I:C) resulted in up-regulation of most S100 genes in the gut and spleen, with highest induction of S100V2 and S100Z detected.	Poly I-C	29-38	S100 calcium binding protein V2	Danio rerio	133-139
31584736-8	2019	Of note, a combination of LPS and the double-stranded RNA, polyinosinic-polycytidylic acid (poly(I:C)), was most potent in increasing FVIII immunogenicity, followed by LPS + R848 (resiquimod).	Poly I-C	59-90	coagulation factor VIII	Homo sapiens	134-139
31683525-7	2019	The strain wtCSFV strongly inhibited IFN-lambdas transcription and IFN-lambda3 promoter activity in poly(I:C)-stimulated IPEC-J2 cells, whereas  Npro did not show such inhibition.	Poly I-C	100-109	interferon lambda 3	Homo sapiens	67-78
31683525-10	2019	However, infection with wtCSFV or Npro overexpression led not only to significant reduction of IRF1 expression and its promoter activity in poly(I:C)-treated IPEC-J2 cells but also to blockage of IRF1 nuclear translocation.	Poly I-C	140-149	interferon regulatory factor 1	Sus scrofa	95-99
31044626-10	2019	Furthermore, the capacity of ILT4+CD1c+ subset producing IFN-gamma was lower than ILT4- CD1c subset in PBMC of HCC patients following Poly I:C stimulation.	Poly I-C	134-142	CD1c molecule	Homo sapiens	34-38
31511519-3	2019	USP19 deficiency increases the production of type I interferons (IFN) and proinflammatory cytokines induced by poly(I:C) or LPS in vitro and in vivo.	Poly I-C	111-120	ubiquitin specific peptidase 19	Mus musculus	0-5
31044626-10	2019	Furthermore, the capacity of ILT4+CD1c+ subset producing IFN-gamma was lower than ILT4- CD1c subset in PBMC of HCC patients following Poly I:C stimulation.	Poly I-C	134-142	interferon gamma	Homo sapiens	57-66
31572376-7	2019	However, TLR3 stimulation using PolyI:C led to an augmented pro-inflammatory cytokine response.	Poly I-C	32-39	toll like receptor 3	Homo sapiens	9-13
31500303-5	2019	Wild type (WT) mice treated with poly(I:C) exhibited altered expression patterns of TNF and IL-12p40 during CASP which were dependent on IFNbeta or IFNAR1, suggesting a mechanism for the increased sepsis susceptibility of WT mice.	Poly I-C	33-42	tumor necrosis factor	Mus musculus	84-87
31500303-5	2019	Wild type (WT) mice treated with poly(I:C) exhibited altered expression patterns of TNF and IL-12p40 during CASP which were dependent on IFNbeta or IFNAR1, suggesting a mechanism for the increased sepsis susceptibility of WT mice.	Poly I-C	33-42	interleukin 12b	Mus musculus	92-100
31500303-5	2019	Wild type (WT) mice treated with poly(I:C) exhibited altered expression patterns of TNF and IL-12p40 during CASP which were dependent on IFNbeta or IFNAR1, suggesting a mechanism for the increased sepsis susceptibility of WT mice.	Poly I-C	33-42	interferon alpha	Mus musculus	137-144
31500303-5	2019	Wild type (WT) mice treated with poly(I:C) exhibited altered expression patterns of TNF and IL-12p40 during CASP which were dependent on IFNbeta or IFNAR1, suggesting a mechanism for the increased sepsis susceptibility of WT mice.	Poly I-C	33-42	interferon (alpha and beta) receptor 1	Mus musculus	148-154
31049957-3	2019	This study aimed to investigate the effect of TLR-3 agonist polyinosinic:polycytidylic acid (Poly I:C) on the expression of inflammatory markers and bone metabolism proteins by human periodontal ligament stem cells (hPDLSCs) compared with TLR-2 agonist Pam3CSK4, which mimics the effect of bacterial lipoproteins.	Poly I-C	93-101	toll like receptor 3	Homo sapiens	46-51
31049957-3	2019	This study aimed to investigate the effect of TLR-3 agonist polyinosinic:polycytidylic acid (Poly I:C) on the expression of inflammatory markers and bone metabolism proteins by human periodontal ligament stem cells (hPDLSCs) compared with TLR-2 agonist Pam3CSK4, which mimics the effect of bacterial lipoproteins.	Poly I-C	93-101	toll like receptor 2	Homo sapiens	239-244
31049957-7	2019	RESULTS: Production of IL-6, IL-8, MCP-1, and OPG was significantly increased by Poly I:C or Pam3CSK4 to a similar extent.	Poly I-C	81-89	interleukin 6	Homo sapiens	23-27
31049957-7	2019	RESULTS: Production of IL-6, IL-8, MCP-1, and OPG was significantly increased by Poly I:C or Pam3CSK4 to a similar extent.	Poly I-C	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
31049957-7	2019	RESULTS: Production of IL-6, IL-8, MCP-1, and OPG was significantly increased by Poly I:C or Pam3CSK4 to a similar extent.	Poly I-C	81-89	C-C motif chemokine ligand 2	Homo sapiens	35-40
31049957-7	2019	RESULTS: Production of IL-6, IL-8, MCP-1, and OPG was significantly increased by Poly I:C or Pam3CSK4 to a similar extent.	Poly I-C	81-89	TNF receptor superfamily member 11b	Homo sapiens	46-49
31511519-4	2019	Usp19-/- mice have more serious inflammation after poly(I:C) or LPS treatment, and are more susceptible to inflammatory damages and death following Salmonella typhimurium infection.	Poly I-C	51-60	ubiquitin specific peptidase 19	Mus musculus	0-5
31497021-11	2019	The results revealed that poly(I:C) stimulation induced TN-C release in vivo, whilst both poly(I:C) stimulation and RV infection promoted release in vitro, with elevated TN-C release from PBECs obtained from people with asthma.	Poly I-C	26-34	tenascin C	Homo sapiens	56-60
31111539-6	2019	Poly (I:C) significantly upregulated proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-1beta and type I interferon (IFN-alpha/beta), and the innate immune responses were significantly reduced by blocking TLR3 signaling.	Poly I-C	0-9	interleukin 1 beta	Homo sapiens	135-143
31111539-6	2019	Poly (I:C) significantly upregulated proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-1beta and type I interferon (IFN-alpha/beta), and the innate immune responses were significantly reduced by blocking TLR3 signaling.	Poly I-C	0-9	interferon alpha 1	Homo sapiens	167-176
31111539-6	2019	Poly (I:C) significantly upregulated proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-1beta and type I interferon (IFN-alpha/beta), and the innate immune responses were significantly reduced by blocking TLR3 signaling.	Poly I-C	0-9	toll like receptor 3	Homo sapiens	255-259
31111539-8	2019	Both silencing of TLR3 and neutralizing TNF-alpha reversed the inhibitory effect of poly (I:C) on P450 aromatase and inhibin expression.	Poly I-C	84-94	toll like receptor 3	Homo sapiens	18-22
31111539-8	2019	Both silencing of TLR3 and neutralizing TNF-alpha reversed the inhibitory effect of poly (I:C) on P450 aromatase and inhibin expression.	Poly I-C	84-94	tumor necrosis factor	Homo sapiens	40-49
31534438-6	2019	We found that poly I:C induced increased expression of the proinflammatory cytokines IL1beta, IL6, CXCL8, and TNF and IFN-beta1 in AECs from both control subjects and COPD patients.	Poly I-C	14-22	interleukin 1 beta	Homo sapiens	85-92
31534438-6	2019	We found that poly I:C induced increased expression of the proinflammatory cytokines IL1beta, IL6, CXCL8, and TNF and IFN-beta1 in AECs from both control subjects and COPD patients.	Poly I-C	14-22	interleukin 6	Homo sapiens	94-97
31534438-6	2019	We found that poly I:C induced increased expression of the proinflammatory cytokines IL1beta, IL6, CXCL8, and TNF and IFN-beta1 in AECs from both control subjects and COPD patients.	Poly I-C	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
31534438-6	2019	We found that poly I:C induced increased expression of the proinflammatory cytokines IL1beta, IL6, CXCL8, and TNF and IFN-beta1 in AECs from both control subjects and COPD patients.	Poly I-C	14-22	tumor necrosis factor	Homo sapiens	110-113
31111539-0	2019	Polyinosinic-polycytidylic acid induces innate immune responses via Toll-like receptor 3 in human ovarian granulosa cells.	Poly I-C	0-31	toll like receptor 3	Homo sapiens	68-88
31111539-6	2019	Poly (I:C) significantly upregulated proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-1beta and type I interferon (IFN-alpha/beta), and the innate immune responses were significantly reduced by blocking TLR3 signaling.	Poly I-C	0-9	tumor necrosis factor	Homo sapiens	74-101
31111539-6	2019	Poly (I:C) significantly upregulated proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-1beta and type I interferon (IFN-alpha/beta), and the innate immune responses were significantly reduced by blocking TLR3 signaling.	Poly I-C	0-9	tumor necrosis factor	Homo sapiens	103-112
31111539-6	2019	Poly (I:C) significantly upregulated proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-1beta and type I interferon (IFN-alpha/beta), and the innate immune responses were significantly reduced by blocking TLR3 signaling.	Poly I-C	0-9	interleukin 6	Homo sapiens	115-133
31497021-11	2019	The results revealed that poly(I:C) stimulation induced TN-C release in vivo, whilst both poly(I:C) stimulation and RV infection promoted release in vitro, with elevated TN-C release from PBECs obtained from people with asthma.	Poly I-C	26-35	tenascin C	Homo sapiens	56-60
31497021-12	2019	Poly(I:C) also induced the release of TN-C-rich sEVs from BEAS-2B cells.	Poly I-C	0-8	tenascin C	Homo sapiens	38-42
31029796-6	2019	We found that prior administration of the viral mimetic poly I:C significantly exacerbated or precipitated the alpha-synuclein aggregate induced neuropathological and behavioral effects.	Poly I-C	56-64	synuclein alpha	Rattus norvegicus	111-126
31531025-5	2019	The data showed that rBM-MSCs expressed TLR3, TLR4, and MDA5 mRNA and were able to internalize polyinosinic-polycytidylic acid (Poly(I:C)), a TLR3/MDA5 agonist.	Poly I-C	95-126	toll-like receptor 3	Rattus norvegicus	142-146
31383943-10	2019	In vivo inhibition of AURKB using the selective inhibitor Barasertib (AZD1152-HQPA) interfered with SMG recovery from the transient, but severe poly (I:C)-mediated injury and cellular depletion.	Poly I-C	144-153	aurora kinase B	Mus musculus	22-27
31381950-0	2019	Fetal liver Mll-AF4+ hematopoietic stem and progenitor cells respond directly to poly(I:C), but not to a single maternal immune activation.	Poly I-C	81-90	lysine (K)-specific methyltransferase 2A	Mus musculus	12-15
31082520-6	2019	Moreover, time course analysis revealed that LcRac1 expression was obviously up-regulated in liver, spleen and head-kidney after immunization with Poly I:C, LPS and Vibrio parahemolyticus.	Poly I-C	147-155	ras-related C3 botulinum toxin substrate 1	Larimichthys crocea	45-51
31041569-7	2019	It was interesting to find that the decreased expression of KDM2B and Brg1 produced similar effects to that of poly(I:C)-treated cells, which could promote inflammatory response of nasal mucosal epithelial cells.	Poly I-C	111-120	lysine demethylase 2B	Homo sapiens	60-65
31041569-7	2019	It was interesting to find that the decreased expression of KDM2B and Brg1 produced similar effects to that of poly(I:C)-treated cells, which could promote inflammatory response of nasal mucosal epithelial cells.	Poly I-C	111-120	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	70-74
31381950-0	2019	Fetal liver Mll-AF4+ hematopoietic stem and progenitor cells respond directly to poly(I:C), but not to a single maternal immune activation.	Poly I-C	81-90	AF4/FMR2 family, member 1	Mus musculus	16-19
30872118-8	2019	In a murine model of neutrophilic airway inflammation induced by HDM and polyinosinic-polycytidylic acid, APOE reached a concentration of 32 nmol/L in epithelial lining fluid, with associated increases in BALF IL-1beta levels.	Poly I-C	73-104	apolipoprotein E	Mus musculus	106-110
31381950-5	2019	We observed an increase in proliferation upon hematopoietic differentiation of fetal liver Mll-AF4+ Lineage-Sca1+ckit+ (LSK) cells exposed to the immune stimulants, poly(I:C) or LPS/lipopolysaccharide.	Poly I-C	165-174	AF4/FMR2 family, member 1	Mus musculus	95-98
31381950-9	2019	Overall, this study suggests that the fetal liver Mll-AF4+ LSK cells are sensitive to direct exposure to inflammatory stimuli, especially poly(I:C); however, maternal immune activation induced by a single exposure to poly(I:C) is not sufficient to initiate MLL-AF4 leukemogenesis.	Poly I-C	138-147	lysine (K)-specific methyltransferase 2A	Mus musculus	50-53
31381950-9	2019	Overall, this study suggests that the fetal liver Mll-AF4+ LSK cells are sensitive to direct exposure to inflammatory stimuli, especially poly(I:C); however, maternal immune activation induced by a single exposure to poly(I:C) is not sufficient to initiate MLL-AF4 leukemogenesis.	Poly I-C	138-147	AF4/FMR2 family, member 1	Mus musculus	54-57
31009295-0	2019	Poly(I:C)-Mediated Death of Human Prostate Cancer Cell Lines Is Induced by Interleukin-27 Treatment.	Poly I-C	0-9	interleukin 27	Homo sapiens	75-89
31232516-9	2019	When we stimulated telocytes with TLR2 or TLR3 agonists (Pam3CSK4, PolyI:C), iNOS expression was greatly increased after Pam3CSK4 treatment.	Poly I-C	67-74	toll-like receptor 2	Mus musculus	34-38
31232516-9	2019	When we stimulated telocytes with TLR2 or TLR3 agonists (Pam3CSK4, PolyI:C), iNOS expression was greatly increased after Pam3CSK4 treatment.	Poly I-C	67-74	toll-like receptor 3	Mus musculus	42-46
31232516-9	2019	When we stimulated telocytes with TLR2 or TLR3 agonists (Pam3CSK4, PolyI:C), iNOS expression was greatly increased after Pam3CSK4 treatment.	Poly I-C	67-74	nitric oxide synthase 2, inducible	Mus musculus	77-81
31009295-5	2019	Our results demonstrate that when IL-27 or IFN-gamma is added with polyinosinic-polycytidylic acid [poly(I:C)], type I IFN (IFN-I) expression increases concurrently with cell death.	Poly I-C	67-98	interleukin 27	Homo sapiens	34-39
31009295-5	2019	Our results demonstrate that when IL-27 or IFN-gamma is added with polyinosinic-polycytidylic acid [poly(I:C)], type I IFN (IFN-I) expression increases concurrently with cell death.	Poly I-C	67-98	interferon gamma	Homo sapiens	43-52
31009295-5	2019	Our results demonstrate that when IL-27 or IFN-gamma is added with polyinosinic-polycytidylic acid [poly(I:C)], type I IFN (IFN-I) expression increases concurrently with cell death.	Poly I-C	100-109	interleukin 27	Homo sapiens	34-39
31009295-5	2019	Our results demonstrate that when IL-27 or IFN-gamma is added with polyinosinic-polycytidylic acid [poly(I:C)], type I IFN (IFN-I) expression increases concurrently with cell death.	Poly I-C	100-109	interferon gamma	Homo sapiens	43-52
31417578-5	2019	We found that oyster IKKalpha/beta-2, a homolog of human IKKalpha/IKKbeta, responded to challenge with lipopolysaccharide (LPS), peptidoglycan (PGN), and polyinosinic-polycytidylic acid [poly(I:C)].	Poly I-C	154-185	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	21-29
31417578-5	2019	We found that oyster IKKalpha/beta-2, a homolog of human IKKalpha/IKKbeta, responded to challenge with lipopolysaccharide (LPS), peptidoglycan (PGN), and polyinosinic-polycytidylic acid [poly(I:C)].	Poly I-C	154-185	glycoprotein hormone subunit alpha 2	Homo sapiens	30-36
31417578-5	2019	We found that oyster IKKalpha/beta-2, a homolog of human IKKalpha/IKKbeta, responded to challenge with lipopolysaccharide (LPS), peptidoglycan (PGN), and polyinosinic-polycytidylic acid [poly(I:C)].	Poly I-C	154-185	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	57-65
31417578-5	2019	We found that oyster IKKalpha/beta-2, a homolog of human IKKalpha/IKKbeta, responded to challenge with lipopolysaccharide (LPS), peptidoglycan (PGN), and polyinosinic-polycytidylic acid [poly(I:C)].	Poly I-C	187-196	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	21-29
31417578-5	2019	We found that oyster IKKalpha/beta-2, a homolog of human IKKalpha/IKKbeta, responded to challenge with lipopolysaccharide (LPS), peptidoglycan (PGN), and polyinosinic-polycytidylic acid [poly(I:C)].	Poly I-C	187-196	glycoprotein hormone subunit alpha 2	Homo sapiens	30-36
31417578-5	2019	We found that oyster IKKalpha/beta-2, a homolog of human IKKalpha/IKKbeta, responded to challenge with lipopolysaccharide (LPS), peptidoglycan (PGN), and polyinosinic-polycytidylic acid [poly(I:C)].	Poly I-C	187-196	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	57-65
31396213-4	2019	Subsequent TLR3 activation by polyinosinic-polycytidylic acid triggers the prominent features of senescence.	Poly I-C	30-61	toll like receptor 3	Homo sapiens	11-15
30776474-0	2019	IL-17c is involved in olfactory mucosa responses to Poly(I:C) mimicking virus presence.	Poly I-C	52-61	interleukin 17C	Mus musculus	0-6
31355218-5	2019	Then, an alteration of AM"s response to poly(I:C) stimulation was observed when the cells were co-stimulated with LL37 and IDR-1002.	Poly I-C	40-49	cathelicidin antimicrobial peptide	Homo sapiens	114-118
31333667-3	2019	The present study was conducted to determine whether selected lactic acid bacteria (LAB) modulate toll-like receptor 3 (TLR3) agonist polyinosinic:polycytidylic acid (PolyI:C) induced viral response in human intestinal epithelial cells (IECs).	Poly I-C	167-174	toll like receptor 3	Homo sapiens	98-118
31333667-3	2019	The present study was conducted to determine whether selected lactic acid bacteria (LAB) modulate toll-like receptor 3 (TLR3) agonist polyinosinic:polycytidylic acid (PolyI:C) induced viral response in human intestinal epithelial cells (IECs).	Poly I-C	167-174	toll like receptor 3	Homo sapiens	120-124
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	interferon beta 1	Homo sapiens	36-51
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	interferon alpha 1	Homo sapiens	53-61
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	interleukin 6	Homo sapiens	64-77
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	interleukin 6	Homo sapiens	79-83
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	86-99
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	C-C motif chemokine ligand 2	Homo sapiens	142-147
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	interleukin 1 beta	Homo sapiens	154-171
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	interleukin 1 alpha	Homo sapiens	173-181
32843831-7	2019	RESULTS: Poly (I:C) exposure reduced the level of 5-methylcytosine (5mC) at synaptic plasticity gene (bdnf, arc, and egr1) promoters in the frontal cortex (FC) and hippocampus of 3-week rats, although increased it later in both regions of 12-week rats as compared to respective controls.	Poly I-C	9-19	brain-derived neurotrophic factor	Rattus norvegicus	102-106
32843831-7	2019	RESULTS: Poly (I:C) exposure reduced the level of 5-methylcytosine (5mC) at synaptic plasticity gene (bdnf, arc, and egr1) promoters in the frontal cortex (FC) and hippocampus of 3-week rats, although increased it later in both regions of 12-week rats as compared to respective controls.	Poly I-C	9-19	early growth response 1	Rattus norvegicus	117-121
30776474-8	2019	Finally, IL-17c decreased cell death induced by Poly(I:C) in an OM primary culture.	Poly I-C	48-57	interleukin 17C	Mus musculus	9-15
31309816-11	2019	In addition, the upregulation of Tlr13, a dsRNA and bacterial 23s rRNA receptor, in the poly(I:C)-stimulated mouse lungs suggests its important role in lung inflammatory responses.	Poly I-C	88-97	toll-like receptor 13	Mus musculus	33-38
31195953-10	2019	The expression of inflammatory genes triggered by poly I:C treatment was noticeably suppressed after RIG-I and TLR3 knockout.	Poly I-C	50-58	DEAD/H box helicase 58	Mus musculus	101-106
30954023-9	2019	In addition, silencing of TLR3 prior to Poly I:C stimulation significantly downregulated IFN-beta secretion.	Poly I-C	40-48	toll like receptor 3	Homo sapiens	26-30
30954023-9	2019	In addition, silencing of TLR3 prior to Poly I:C stimulation significantly downregulated IFN-beta secretion.	Poly I-C	40-48	IFN1@	Homo sapiens	89-97
31195953-10	2019	The expression of inflammatory genes triggered by poly I:C treatment was noticeably suppressed after RIG-I and TLR3 knockout.	Poly I-C	50-58	toll-like receptor 3	Mus musculus	111-115
31195953-12	2019	Moreover, RIG-I and TLR3 contributed to the modulation of poly I:C-triggered inflammatory cytokine generation during orchitis in testicular cells.	Poly I-C	58-66	DEAD/H box helicase 58	Mus musculus	10-15
31195953-12	2019	Moreover, RIG-I and TLR3 contributed to the modulation of poly I:C-triggered inflammatory cytokine generation during orchitis in testicular cells.	Poly I-C	58-66	toll-like receptor 3	Mus musculus	20-24
33911592-4	2019	The aim of this study is to demonstrate the effects of SAA in poly(I:C)-induced inflammatory reaction in skin keratinocytes.	Poly I-C	62-71	serum amyloid A1 cluster	Homo sapiens	55-58
30924965-10	2019	Conversely, poly(I:C) imposed significant decreases in the protein expression of ASCT1 and EAAT2 in placenta and expression of SNAT5, EAAT1, and GLYT1 in fetal brain.	Poly I-C	12-21	solute carrier family 1 member 4	Rattus norvegicus	81-86
30924965-10	2019	Conversely, poly(I:C) imposed significant decreases in the protein expression of ASCT1 and EAAT2 in placenta and expression of SNAT5, EAAT1, and GLYT1 in fetal brain.	Poly I-C	12-21	solute carrier family 1 member 2	Rattus norvegicus	91-96
30924965-10	2019	Conversely, poly(I:C) imposed significant decreases in the protein expression of ASCT1 and EAAT2 in placenta and expression of SNAT5, EAAT1, and GLYT1 in fetal brain.	Poly I-C	12-21	solute carrier family 1 member 3	Rattus norvegicus	134-139
30924965-10	2019	Conversely, poly(I:C) imposed significant decreases in the protein expression of ASCT1 and EAAT2 in placenta and expression of SNAT5, EAAT1, and GLYT1 in fetal brain.	Poly I-C	12-21	solute carrier family 6 member 9	Rattus norvegicus	145-150
31262388-8	2019	In BALB/c mice, Rv0674 adjuvant by DDA/Poly I:C could also induce a high level of IFN-gamma, interleukin-2 and interleukin-6 as well as a high IgG titer in both high- and low-dose groups indicating that Rv0674 is essential in humoral and cellular immunity.	Poly I-C	39-47	interferon gamma	Mus musculus	82-91
31262388-8	2019	In BALB/c mice, Rv0674 adjuvant by DDA/Poly I:C could also induce a high level of IFN-gamma, interleukin-2 and interleukin-6 as well as a high IgG titer in both high- and low-dose groups indicating that Rv0674 is essential in humoral and cellular immunity.	Poly I-C	39-47	interleukin 2	Mus musculus	93-106
31262388-8	2019	In BALB/c mice, Rv0674 adjuvant by DDA/Poly I:C could also induce a high level of IFN-gamma, interleukin-2 and interleukin-6 as well as a high IgG titer in both high- and low-dose groups indicating that Rv0674 is essential in humoral and cellular immunity.	Poly I-C	39-47	interleukin 6	Mus musculus	111-124
31160675-5	2019	The results indicated that poly I:C alone and in combination with Pam3CSK4 alleviated vaccine-induced immunosuppression, as evidenced by greater weight gain, increased overall antibody responses to both sheep erythrocytes and live infectious bronchitis virus vaccine, upregulated IFN-gamma transcripts and nitric oxide production by PBMCs (P < 0.05), and lower bursal lesion score in the experimental birds.	Poly I-C	27-35	interferon gamma	Homo sapiens	280-289
33911592-5	2019	Methods: We pre-treated keratinocytes with SAA then stimulated with poly(I:C).	Poly I-C	68-77	serum amyloid A1 cluster	Homo sapiens	43-46
33911592-7	2019	Results: When skin keratinocytes were pre-treated with SAA, it significantly inhibited poly (I:C)-induced expression of inflammatory cytokines including interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor-alpha, and CCL20.	Poly I-C	87-97	serum amyloid A1 cluster	Homo sapiens	55-58
33911592-7	2019	Results: When skin keratinocytes were pre-treated with SAA, it significantly inhibited poly (I:C)-induced expression of inflammatory cytokines including interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor-alpha, and CCL20.	Poly I-C	87-97	interleukin 1 alpha	Homo sapiens	153-175
33911592-7	2019	Results: When skin keratinocytes were pre-treated with SAA, it significantly inhibited poly (I:C)-induced expression of inflammatory cytokines including interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor-alpha, and CCL20.	Poly I-C	87-97	interleukin 6	Homo sapiens	177-181
33911592-7	2019	Results: When skin keratinocytes were pre-treated with SAA, it significantly inhibited poly (I:C)-induced expression of inflammatory cytokines including interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor-alpha, and CCL20.	Poly I-C	87-97	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
33911592-7	2019	Results: When skin keratinocytes were pre-treated with SAA, it significantly inhibited poly (I:C)-induced expression of inflammatory cytokines including interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor-alpha, and CCL20.	Poly I-C	87-97	tumor necrosis factor	Homo sapiens	189-216
33911592-7	2019	Results: When skin keratinocytes were pre-treated with SAA, it significantly inhibited poly (I:C)-induced expression of inflammatory cytokines including interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor-alpha, and CCL20.	Poly I-C	87-97	C-C motif chemokine ligand 20	Homo sapiens	222-227
33911592-8	2019	SAA inhibited poly(I:C)-induced activation of nuclear factor-kappaB signaling.	Poly I-C	14-23	serum amyloid A1 cluster	Homo sapiens	0-3
33911592-10	2019	Finally, SAA markedly inhibited poly(I:C)-induced NLRP3 expression.	Poly I-C	32-41	serum amyloid A1 cluster	Homo sapiens	9-12
33911592-10	2019	Finally, SAA markedly inhibited poly(I:C)-induced NLRP3 expression.	Poly I-C	32-41	NLR family pyrin domain containing 3	Homo sapiens	50-55
33911592-11	2019	Conclusion: These results demonstrate that SAA has an inhibitory effect on poly(I:C)-induced inflammatory reaction of keratinocytes, suggesting that SAA can be developed for the treatment of inflammatory skin diseases such as psoriasis.	Poly I-C	75-84	serum amyloid A1 cluster	Homo sapiens	43-46
33911592-11	2019	Conclusion: These results demonstrate that SAA has an inhibitory effect on poly(I:C)-induced inflammatory reaction of keratinocytes, suggesting that SAA can be developed for the treatment of inflammatory skin diseases such as psoriasis.	Poly I-C	75-84	serum amyloid A1 cluster	Homo sapiens	149-152
31130960-0	2019	TLR3 Ligand PolyI:C Prevents Acute Pancreatitis Through the Interferon-beta/Interferon-alpha/beta Receptor Signaling Pathway in a Caerulein-Induced Pancreatitis Mouse Model.	Poly I-C	12-19	toll-like receptor 3	Mus musculus	0-4
30807809-13	2019	While Poly I:C WL offspring displayed hypersynchronicity in the DMN, altered NMDAR antagonist response was most pronounced in Poly I:C WG offspring.	Poly I-C	6-14	synemin	Rattus norvegicus	64-67
30715797-4	2019	Stimulation with poly (I:C) LMW induces a 15- to 17-fold increase in IL-6 production by HNEC-ALI cells.	Poly I-C	17-31	interleukin 6	Homo sapiens	69-73
30999161-7	2019	Quantitative real-time PCR (qRT-PCR) analysis revealed that duck IFIT5 expression rapidly increased both in vitro and in vivo after stimulation with polyinosinic:polycytidylic acid [poly (I:C)] and infection with virulent duck hepatitis A virus type 3 (DHAV-3), respectively.	Poly I-C	149-180	interferon induced protein with tetratricopeptide repeats 5	Gallus gallus	65-70
31143178-1	2019	Upon treatment with polyinosinic:polycytidylic acid [poly(I:C)], an artificial double-stranded RNA, type I interferon receptor-deficient (IFNAR-/-) mice develop severe liver injury seen by enhanced alanine aminotransferase (ALT) activity in the serum that is not observed in their wildtype (WT) counterparts.	Poly I-C	20-51	interferon (alpha and beta) receptor 1	Mus musculus	138-143
31143178-1	2019	Upon treatment with polyinosinic:polycytidylic acid [poly(I:C)], an artificial double-stranded RNA, type I interferon receptor-deficient (IFNAR-/-) mice develop severe liver injury seen by enhanced alanine aminotransferase (ALT) activity in the serum that is not observed in their wildtype (WT) counterparts.	Poly I-C	20-51	glutamic pyruvic transaminase, soluble	Mus musculus	198-222
31143178-1	2019	Upon treatment with polyinosinic:polycytidylic acid [poly(I:C)], an artificial double-stranded RNA, type I interferon receptor-deficient (IFNAR-/-) mice develop severe liver injury seen by enhanced alanine aminotransferase (ALT) activity in the serum that is not observed in their wildtype (WT) counterparts.	Poly I-C	20-51	glutamic pyruvic transaminase, soluble	Mus musculus	224-227
31143178-8	2019	Accordingly, mice double-deficient for IFNAR and IL1R1 developed no liver injury upon poly(I:C) treatment and showed ALT activities comparable to those of WT mice.	Poly I-C	86-95	interferon (alpha and beta) receptor 1	Mus musculus	39-44
31143178-8	2019	Accordingly, mice double-deficient for IFNAR and IL1R1 developed no liver injury upon poly(I:C) treatment and showed ALT activities comparable to those of WT mice.	Poly I-C	86-95	interleukin 1 receptor, type I	Mus musculus	49-54
31130960-0	2019	TLR3 Ligand PolyI:C Prevents Acute Pancreatitis Through the Interferon-beta/Interferon-alpha/beta Receptor Signaling Pathway in a Caerulein-Induced Pancreatitis Mouse Model.	Poly I-C	12-19	interferon beta 1, fibroblast	Mus musculus	60-75
31130960-4	2019	Toll-like receptor 3 (TLR3) ligand polyI:C is a double-stranded RNA mimic that can be used as an immune stimulant.	Poly I-C	35-42	toll-like receptor 3	Mus musculus	0-20
31130960-4	2019	Toll-like receptor 3 (TLR3) ligand polyI:C is a double-stranded RNA mimic that can be used as an immune stimulant.	Poly I-C	35-42	toll-like receptor 3	Mus musculus	22-26
31130960-5	2019	Our current study indicates that polyI:C exerted excellent anti-inflammatory effects in a caerulein-induced AP mouse model and taurocholate-induced pancreatic acinar cell line injury model.	Poly I-C	33-40	LIM homeobox protein 2	Mus musculus	108-110
31130960-6	2019	We found that polyI:C triggers type I interferon (IFN) production and downstream IFN-alpha/beta receptor (IFNAR)-dependent signaling, which play key roles in protecting the pancreas from inflammatory injury.	Poly I-C	14-21	interferon (alpha and beta) receptor 1	Mus musculus	106-111
31130960-7	2019	Knockout of IFN-beta and IFNAR in mice abolished the preventive effects of polyI:C on caerulein-induced AP symptoms, which include pancreatic edema, neutrophil infiltration, the accumulation of reactive oxygen species (ROS), and inflammatory gene expression.	Poly I-C	75-82	interferon alpha	Mus musculus	12-20
31130960-7	2019	Knockout of IFN-beta and IFNAR in mice abolished the preventive effects of polyI:C on caerulein-induced AP symptoms, which include pancreatic edema, neutrophil infiltration, the accumulation of reactive oxygen species (ROS), and inflammatory gene expression.	Poly I-C	75-82	interferon (alpha and beta) receptor 1	Mus musculus	25-30
31130960-8	2019	Treating pancreatic acinar 266-6 cells with an IFNAR inhibitor, which blocks the interaction between type I IFN and IFNAR, diminishes the downregulation of oxidative stress by polyI:C.	Poly I-C	176-183	interferon (alpha and beta) receptor 1	Mus musculus	47-52
31130960-8	2019	Treating pancreatic acinar 266-6 cells with an IFNAR inhibitor, which blocks the interaction between type I IFN and IFNAR, diminishes the downregulation of oxidative stress by polyI:C.	Poly I-C	176-183	interferon (alpha and beta) receptor 1	Mus musculus	116-121
31130960-10	2019	Thus, polyI:C may act as a type I IFN inducer to alleviate AP, and it has the potential to be a promising therapeutic agent used at the early stages of AP.	Poly I-C	6-13	LIM homeobox protein 2	Mus musculus	59-61
31046839-1	2019	Poly I:C is a powerful immune adjuvant as a result of its agonist activities on TLR-3, MDA5 and RIG-I.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	80-85
31046839-1	2019	Poly I:C is a powerful immune adjuvant as a result of its agonist activities on TLR-3, MDA5 and RIG-I.	Poly I-C	0-8	interferon induced with helicase C domain 1	Homo sapiens	87-91
30648905-6	2019	In epithelial cells, palmitic acid (SFA) combined with poly(I:C) also led to greater IL-6 release.	Poly I-C	55-64	interleukin 6	Homo sapiens	85-89
31046839-1	2019	Poly I:C is a powerful immune adjuvant as a result of its agonist activities on TLR-3, MDA5 and RIG-I.	Poly I-C	0-8	DExD/H-box helicase 58	Homo sapiens	96-101
31057355-6	2019	Poly(I:C) increased the circulating levels of cytokines (TNF-alpha, MCP-1, IL-6, IL-10, IFN-alpha, IFN-gamma), an effect amplified by IF.	Poly I-C	0-8	tumor necrosis factor	Mus musculus	57-66
30811246-4	2019	In contrast, macrophage activation in response to poly(I:C) is attenuated in macrophages isolated from mice lacking CCR5.	Poly I-C	50-59	chemokine (C-C motif) receptor 5	Mus musculus	116-120
30710579-13	2019	Activation of primary macrophage cultures with Poly (I:C) induced translocation of IRF3 to the mitochondria, where it associated with Bax and activated caspases 3 and 9, processes indicative of activation of the RIPA pathway.	Poly I-C	47-56	interferon regulatory factor 3	Mus musculus	83-87
30710579-13	2019	Activation of primary macrophage cultures with Poly (I:C) induced translocation of IRF3 to the mitochondria, where it associated with Bax and activated caspases 3 and 9, processes indicative of activation of the RIPA pathway.	Poly I-C	47-56	BCL2-associated X protein	Mus musculus	134-137
30710579-13	2019	Activation of primary macrophage cultures with Poly (I:C) induced translocation of IRF3 to the mitochondria, where it associated with Bax and activated caspases 3 and 9, processes indicative of activation of the RIPA pathway.	Poly I-C	47-56	caspase 3	Mus musculus	152-168
31105693-7	2019	Moreover, poly(I:C) up regulated the expression of costimulatory molecules in both cDC1 and cDC2 DCs subsets.	Poly I-C	10-19	cyclin dependent kinase 1	Homo sapiens	92-96
31105808-1	2019	PolyI:C as a ligand of toll-like receptor 3 has been explored as a nucleic acid therapeutic agent for anti-tumor therapy.	Poly I-C	0-7	toll-like receptor 3	Mus musculus	23-43
31105808-3	2019	However, there is a lack of information about the ability of PolyI:C to affect PI3K/Akt/p53 signaling pathway in non-small cell lung cancer (NSCLC), and its pharmacodynamic evaluation in vivo still remain unclear so far.	Poly I-C	61-68	thymoma viral proto-oncogene 1	Mus musculus	84-87
31105808-3	2019	However, there is a lack of information about the ability of PolyI:C to affect PI3K/Akt/p53 signaling pathway in non-small cell lung cancer (NSCLC), and its pharmacodynamic evaluation in vivo still remain unclear so far.	Poly I-C	61-68	transformation related protein 53, pseudogene	Mus musculus	88-91
31105808-8	2019	Our results confirmed that PolyI:C increased the expression of CD80, CD86 in spleen dendritic cells of tumor-bearing mice and cytokine secretion in healthy mice.	Poly I-C	27-34	CD80 antigen	Mus musculus	63-67
31105808-8	2019	Our results confirmed that PolyI:C increased the expression of CD80, CD86 in spleen dendritic cells of tumor-bearing mice and cytokine secretion in healthy mice.	Poly I-C	27-34	CD86 antigen	Mus musculus	69-73
30990863-11	2019	Complexes of endogenous IFNalpha and intrabody could be visualized in the ER of Poly (I:C) stimulated RAW 264.7 macrophages and D1 dendritic cells.	Poly I-C	80-90	interferon alpha	Mus musculus	24-32
30987646-4	2019	METHODS: Human microvascular endothelial cells (HMVECs) were exposed to either control or eNOS siRNA and then treated with Poly I:C, a TLR3 agonist and mimicker of dsRNA viruses.	Poly I-C	123-131	toll like receptor 3	Homo sapiens	135-139
30987646-6	2019	RESULTS: HMVECs that had reduced eNOS expression had a significantly elevated increase in IL-6, IL-8 and IP-10 production after Poly I:C.	Poly I-C	128-136	nitric oxide synthase 3	Homo sapiens	33-37
30987646-6	2019	RESULTS: HMVECs that had reduced eNOS expression had a significantly elevated increase in IL-6, IL-8 and IP-10 production after Poly I:C.	Poly I-C	128-136	interleukin 6	Homo sapiens	90-94
30987646-6	2019	RESULTS: HMVECs that had reduced eNOS expression had a significantly elevated increase in IL-6, IL-8 and IP-10 production after Poly I:C.	Poly I-C	128-136	C-X-C motif chemokine ligand 10	Homo sapiens	105-110
30987646-7	2019	In addition, the knockdown of eNOS enhanced the change in TEER after Poly I:C stimulation.	Poly I-C	69-77	nitric oxide synthase 3	Homo sapiens	30-34
30987646-8	2019	Western blot analysis showed enhanced phosphorylation of p38 in sieNOS treated cells with Poly I:C compared to siControl cells.	Poly I-C	90-98	mitogen-activated protein kinase 14	Homo sapiens	57-60
30987646-10	2019	The addition of the p38 inhibitor, SB203580, in eNOS knockdown cells reduced both cytokine production after Poly I:C, and as well as mitigated the reduction in TEER, suggesting a direct link between eNOS and p38 in TLR3 signaling.	Poly I-C	108-116	mitogen-activated protein kinase 14	Homo sapiens	20-23
30987646-10	2019	The addition of the p38 inhibitor, SB203580, in eNOS knockdown cells reduced both cytokine production after Poly I:C, and as well as mitigated the reduction in TEER, suggesting a direct link between eNOS and p38 in TLR3 signaling.	Poly I-C	108-116	nitric oxide synthase 3	Homo sapiens	48-52
31057355-6	2019	Poly(I:C) increased the circulating levels of cytokines (TNF-alpha, MCP-1, IL-6, IL-10, IFN-alpha, IFN-gamma), an effect amplified by IF.	Poly I-C	0-8	mast cell protease 1	Mus musculus	68-73
31057355-6	2019	Poly(I:C) increased the circulating levels of cytokines (TNF-alpha, MCP-1, IL-6, IL-10, IFN-alpha, IFN-gamma), an effect amplified by IF.	Poly I-C	0-8	interleukin 6	Mus musculus	75-79
31057355-6	2019	Poly(I:C) increased the circulating levels of cytokines (TNF-alpha, MCP-1, IL-6, IL-10, IFN-alpha, IFN-gamma), an effect amplified by IF.	Poly I-C	0-8	interleukin 10	Mus musculus	81-86
31057355-6	2019	Poly(I:C) increased the circulating levels of cytokines (TNF-alpha, MCP-1, IL-6, IL-10, IFN-alpha, IFN-gamma), an effect amplified by IF.	Poly I-C	0-8	interferon alpha	Mus musculus	88-97
31057355-6	2019	Poly(I:C) increased the circulating levels of cytokines (TNF-alpha, MCP-1, IL-6, IL-10, IFN-alpha, IFN-gamma), an effect amplified by IF.	Poly I-C	0-8	interferon gamma	Mus musculus	99-108
31057547-4	2019	Knockdown of chDDX3X decreased the production of IFN-beta induced by RNA analog polyinosinic-polycytidylic acid and increased viral yield.	Poly I-C	80-111	IFN1@	Homo sapiens	49-57
31058074-0	2019	Combined Adjuvant of Poly I:C Improves Antitumor Effects of CAR-T Cells.	Poly I-C	21-29	nuclear receptor subfamily 1, group I, member 3	Mus musculus	60-63
30842273-5	2019	The inhibitor AMN107 inhibits IFN-beta production induced by poly(dA:dT), poly(I:C), and Sendai virus in THP-1 and mouse bone marrow-derived macrophage cells.	Poly I-C	74-82	interferon beta 1, fibroblast	Mus musculus	30-38
31058074-3	2019	Polyinosinic-polycytidylic acid (poly I:C), ligand of TLR3, mediates innate immune and adaptive immune and shows broad antitumor effect on many types of cancer.	Poly I-C	0-31	toll-like receptor 3	Mus musculus	54-58
31058074-5	2019	Poly I:C significantly promoted more IL-2 and IFN gamma production as well as higher lytic activity of CAR-T cells.	Poly I-C	0-8	interleukin 2	Mus musculus	37-41
31058074-5	2019	Poly I:C significantly promoted more IL-2 and IFN gamma production as well as higher lytic activity of CAR-T cells.	Poly I-C	0-8	interferon gamma	Mus musculus	46-55
31058074-5	2019	Poly I:C significantly promoted more IL-2 and IFN gamma production as well as higher lytic activity of CAR-T cells.	Poly I-C	0-8	nuclear receptor subfamily 1, group I, member 3	Mus musculus	103-106
31058074-8	2019	In addition, poly I:C decreased myeloid-derived suppressor cells (MDSC) number in peripheral blood and spleen, and attenuated the immunosuppressive activity of MDSC on proliferation and cytolytic function of CAR-T.	Poly I-C	13-21	CART prepropeptide	Mus musculus	208-213
30880119-3	2019	Given that it is unclear whether viral infections result in similar age and sex differences, the objective of this study was to examine the acute immune and stress responses following exposure to polyinosinic:polycytidylic acid (poly(I:C)), a viral mimetic, in CD1 mice and to investigate the role of gonadal hormones in these responses.	Poly I-C	196-227	CD1 antigen complex	Mus musculus	261-264
30758056-4	2019	Herein we observed that CpG and PolyI:C, two stimuli mimicking bacterial and viral nucleic acids respectively, strongly inhibited c-kit expression by BMdDCs and spleen DCs in vitro and in vivo.	Poly I-C	32-39	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	130-135
30758056-6	2019	Furthermore, CpG and PolyI:C strongly inhibited c-kit mRNA expression.	Poly I-C	21-28	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	48-53
30758056-8	2019	Thus in the presence of exogenously provided SCF, either PolyI:C or CpG induced spleen DC death in 2 days, while at earlier times IL-6 and IL-12 production were slightly increased.	Poly I-C	57-64	kit ligand	Mus musculus	45-48
30362580-8	2019	LPS and Poly(I:C) upregulated the YAP expression in nasal epithelial cells accompanied by increased TEAD1 and Ki-67 expression.	Poly I-C	8-17	Yes1 associated transcriptional regulator	Homo sapiens	34-37
30362580-8	2019	LPS and Poly(I:C) upregulated the YAP expression in nasal epithelial cells accompanied by increased TEAD1 and Ki-67 expression.	Poly I-C	8-17	TEA domain transcription factor 1	Homo sapiens	100-105
30341573-4	2019	METHODS: We examined the effect of polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA, on PAI-1 and tissue plasminogen activator (t-PA) expression in GECs.	Poly I-C	35-66	serpin family E member 1	Homo sapiens	115-159
30341573-4	2019	METHODS: We examined the effect of polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA, on PAI-1 and tissue plasminogen activator (t-PA) expression in GECs.	Poly I-C	68-75	serpin family E member 1	Homo sapiens	115-159
30803844-4	2019	Poly(I:C) and CpG readily adsorbed onto AH and this combination adjuvant induced a stronger IgG1 and IgG2a immune response with a significant increase of antibody avidity.	Poly I-C	0-8	LOC105243590	Mus musculus	92-96
30803844-4	2019	Poly(I:C) and CpG readily adsorbed onto AH and this combination adjuvant induced a stronger IgG1 and IgG2a immune response with a significant increase of antibody avidity.	Poly I-C	0-8	immunoglobulin heavy variable V1-9	Mus musculus	101-106
30971945-8	2019	Six hours after poly I:C, caspase-3 and -8 activities in cytosolic fractions were 1.6 and 2.8-fold higher in poly I:C-treated than in NS-treated female mice, respectively, while gene expressions of pro-inflammatory cytokines were upregulated in both sexes.	Poly I-C	16-24	caspase 3	Mus musculus	26-42
30971945-8	2019	Six hours after poly I:C, caspase-3 and -8 activities in cytosolic fractions were 1.6 and 2.8-fold higher in poly I:C-treated than in NS-treated female mice, respectively, while gene expressions of pro-inflammatory cytokines were upregulated in both sexes.	Poly I-C	109-117	caspase 3	Mus musculus	26-42
30971945-9	2019	After poly I:C, IRF3 nuclear translocation occurred earlier (6 h) in female mice and later (14 h) in male mice.	Poly I-C	6-14	interferon regulatory factor 3	Mus musculus	16-20
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Poly I-C	79-87	latexin	Homo sapiens	18-21
30836963-12	2019	The levels of proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in the offspring of the Poly I:C-exposed mothers differed with brain region and time, with more cytokines elevated during periadolescence than during adulthood.	Poly I-C	96-104	interleukin 1 beta	Rattus norvegicus	41-49
30836963-12	2019	The levels of proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in the offspring of the Poly I:C-exposed mothers differed with brain region and time, with more cytokines elevated during periadolescence than during adulthood.	Poly I-C	96-104	interleukin 6	Rattus norvegicus	51-55
30836963-12	2019	The levels of proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in the offspring of the Poly I:C-exposed mothers differed with brain region and time, with more cytokines elevated during periadolescence than during adulthood.	Poly I-C	96-104	tumor necrosis factor	Rattus norvegicus	61-70
30626688-8	2019	However, TMPRSS2-KO mice showed weakened inflammatory chemokine and/or cytokine responses to intranasal stimulation with poly(I C), a Toll-like receptor 3 agonist.	Poly I-C	121-130	transmembrane protease, serine 2	Mus musculus	9-16
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Poly I-C	79-87	latexin	Homo sapiens	31-34
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Poly I-C	79-87	latexin	Homo sapiens	31-34
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Poly I-C	79-87	inositol-3-phosphate synthase 1	Homo sapiens	108-112
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Poly I-C	79-87	nuclear factor kappa B subunit 1	Homo sapiens	114-123
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Poly I-C	79-87	RELA proto-oncogene, NF-kB subunit	Homo sapiens	124-127
30508574-4	2019	N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells.	Poly I-C	79-87	interleukin 6	Homo sapiens	130-134
30508574-6	2019	On the other hand, poly I:C caused a marked reduction in DCX immunoexpression, which was prevented only by clozapine.	Poly I-C	19-27	doublecortin	Homo sapiens	57-60
30787349-10	2019	Deferiprone blocked Poly (I:C)-induced IL-6 production by HNECs but did not alter their migration in scratch assays.	Poly I-C	20-30	interleukin 6	Homo sapiens	39-43
30550930-2	2019	Activation of toll-like receptor 3 (TLR3) by polyinosinic:polycytidylic acid (poly(I:C)) produced a rapid proinflammatory response in males that increased alcohol intake over time (Warden et al., 2019).	Poly I-C	78-87	toll-like receptor 3	Mus musculus	14-34
30550930-2	2019	Activation of toll-like receptor 3 (TLR3) by polyinosinic:polycytidylic acid (poly(I:C)) produced a rapid proinflammatory response in males that increased alcohol intake over time (Warden et al., 2019).	Poly I-C	78-87	toll-like receptor 3	Mus musculus	36-40
30550930-9	2019	To validate the effects of poly(I:C) were mediated through MyD88, we tested female mice lacking Myd88.	Poly I-C	27-36	myeloid differentiation primary response gene 88	Mus musculus	59-64
30550931-8	2019	Repeated poly(I:C) and ethanol exposure altered innate immune transcript abundance; increased levels of TRIF-dependent pathway components correlated with increased alcohol consumption.	Poly I-C	9-18	toll-like receptor adaptor molecule 2	Mus musculus	104-108
30550931-11	2019	MyD88 null mutants showed poly(I:C)-induced increases in alcohol intake.	Poly I-C	26-35	myeloid differentiation primary response gene 88	Mus musculus	0-5
30478640-7	2019	RESULTS: DEXI-silenced beta cells exposed to a synthetic double-stranded RNA (polyinosinic:polycytidylic acid [PIC], a by-product of viral replication) showed reduced activation of signal transducer and activator of transcription (STAT) 1 and lower production of proinflammatory chemokines that was preceded by a reduction in IFNbeta levels.	Poly I-C	111-114	Dexi homolog	Homo sapiens	9-13
30478640-7	2019	RESULTS: DEXI-silenced beta cells exposed to a synthetic double-stranded RNA (polyinosinic:polycytidylic acid [PIC], a by-product of viral replication) showed reduced activation of signal transducer and activator of transcription (STAT) 1 and lower production of proinflammatory chemokines that was preceded by a reduction in IFNbeta levels.	Poly I-C	111-114	signal transducer and activator of transcription 1	Homo sapiens	181-238
30863402-8	2019	ICP27 significantly suppresses the Sendai virus or polyinosinic-polycytidylic acid-induced IFN-beta production in human mucosal epithelial cells, showing that ICP27 inhibits the IFN-beta promoter activation, and IFN-beta production at both mRNA and protein levels.	Poly I-C	51-82	IFN1@	Homo sapiens	91-99
30863402-8	2019	ICP27 significantly suppresses the Sendai virus or polyinosinic-polycytidylic acid-induced IFN-beta production in human mucosal epithelial cells, showing that ICP27 inhibits the IFN-beta promoter activation, and IFN-beta production at both mRNA and protein levels.	Poly I-C	51-82	IFN1@	Homo sapiens	178-186
30863402-8	2019	ICP27 significantly suppresses the Sendai virus or polyinosinic-polycytidylic acid-induced IFN-beta production in human mucosal epithelial cells, showing that ICP27 inhibits the IFN-beta promoter activation, and IFN-beta production at both mRNA and protein levels.	Poly I-C	51-82	IFN1@	Homo sapiens	178-186
31069136-7	2019	Nonetheless, poly(I:C)-mediated tumor regression and change in the myeloid cell landscape was dependent on IL-6.	Poly I-C	13-22	interleukin 6	Homo sapiens	107-111
30781517-3	2019	Poly-inosinic-cytidylic acid [poly (I:C)] is a synthetic dsRNA toll-like receptor 3 (TLR3) agonist that possesses a number of biological properties that includes the in vivo activation of NK cells.	Poly I-C	30-40	toll-like receptor 3	Mus musculus	85-89
30550931-12	2019	In contrast, mice pretreated with a TLR3/dsRNA complex inhibitor reduced their alcohol intake, suggesting poly(I:C)-induced escalations in alcohol intake are, at least partially, dependent on TLR3.	Poly I-C	106-115	toll-like receptor 3	Mus musculus	36-40
30550931-12	2019	In contrast, mice pretreated with a TLR3/dsRNA complex inhibitor reduced their alcohol intake, suggesting poly(I:C)-induced escalations in alcohol intake are, at least partially, dependent on TLR3.	Poly I-C	106-115	toll-like receptor 3	Mus musculus	192-196
30699353-3	2019	Ectopic expression of DDX19 suppressed poly(I:C) (polyinosinic-polycytidylic acid)- and Sendai-virus-induced type I IFN production, whereas knockdown of DDX19 expression enhanced type I IFN production.	Poly I-C	39-48	DEAD-box helicase 19B	Homo sapiens	22-27
30421962-2	2019	The purpose of the present study was to determine if intracerebroventricular (ICV) and intraperitoneal (IP) injection of polyinosinic-polycytidylic acid (poly I:C), a viral mimetic that binds to toll-like receptor-3 (TLR3), affects food intake, voluntary activity, cloacal temperature, plasma corticosterone (CORT) and glucose concentrations, and crop emptying rate in chicks (Gallus gallus).	Poly I-C	121-152	toll like receptor 3	Gallus gallus	195-215
30421962-2	2019	The purpose of the present study was to determine if intracerebroventricular (ICV) and intraperitoneal (IP) injection of polyinosinic-polycytidylic acid (poly I:C), a viral mimetic that binds to toll-like receptor-3 (TLR3), affects food intake, voluntary activity, cloacal temperature, plasma corticosterone (CORT) and glucose concentrations, and crop emptying rate in chicks (Gallus gallus).	Poly I-C	121-152	toll like receptor 3	Gallus gallus	217-221
30421962-2	2019	The purpose of the present study was to determine if intracerebroventricular (ICV) and intraperitoneal (IP) injection of polyinosinic-polycytidylic acid (poly I:C), a viral mimetic that binds to toll-like receptor-3 (TLR3), affects food intake, voluntary activity, cloacal temperature, plasma corticosterone (CORT) and glucose concentrations, and crop emptying rate in chicks (Gallus gallus).	Poly I-C	121-152	CORT	Gallus gallus	309-313
30421962-7	2019	Both ICV and IP injection of poly I:C significantly increased plasma CORT and glucose concentration.	Poly I-C	29-37	CORT	Gallus gallus	69-73
30182341-0	2019	Radio-sensitization of head and neck cancer cells by a combination of poly(I:C) and cisplatin through downregulation of survivin and c-IAP2.	Poly I-C	70-79	baculoviral IAP repeat containing 3	Homo sapiens	133-139
30699353-3	2019	Ectopic expression of DDX19 suppressed poly(I:C) (polyinosinic-polycytidylic acid)- and Sendai-virus-induced type I IFN production, whereas knockdown of DDX19 expression enhanced type I IFN production.	Poly I-C	50-82	DEAD-box helicase 19B	Homo sapiens	22-27
30691477-3	2019	We tested the hypothesis that Map2k7 gene haploinsufficiency in mice would alter the prenatal immune response to the viral mimetic polyriboinosinic-polyribocytidylic acid (polyI:C), specifically investigating the impact of maternal versus foetal genetic variants.	Poly I-C	131-170	mitogen-activated protein kinase kinase 7	Mus musculus	30-36
30691477-3	2019	We tested the hypothesis that Map2k7 gene haploinsufficiency in mice would alter the prenatal immune response to the viral mimetic polyriboinosinic-polyribocytidylic acid (polyI:C), specifically investigating the impact of maternal versus foetal genetic variants.	Poly I-C	172-179	mitogen-activated protein kinase kinase 7	Mus musculus	30-36
30691477-7	2019	Maternal polyI:C administration also increased embryonic brain chemokines, influenced by both maternal and embryonic genotype: CCL5 and CXCL10 levels were higher in embryonic brains from Map2k7 dams versus control dams; for CCL5, this was more pronounced in Map2k7 Hz embryos.	Poly I-C	9-16	chemokine (C-C motif) ligand 5	Mus musculus	127-131
30691477-7	2019	Maternal polyI:C administration also increased embryonic brain chemokines, influenced by both maternal and embryonic genotype: CCL5 and CXCL10 levels were higher in embryonic brains from Map2k7 dams versus control dams; for CCL5, this was more pronounced in Map2k7 Hz embryos.	Poly I-C	9-16	chemokine (C-X-C motif) ligand 10	Mus musculus	136-142
30691477-7	2019	Maternal polyI:C administration also increased embryonic brain chemokines, influenced by both maternal and embryonic genotype: CCL5 and CXCL10 levels were higher in embryonic brains from Map2k7 dams versus control dams; for CCL5, this was more pronounced in Map2k7 Hz embryos.	Poly I-C	9-16	mitogen-activated protein kinase kinase 7	Mus musculus	187-193
30691477-7	2019	Maternal polyI:C administration also increased embryonic brain chemokines, influenced by both maternal and embryonic genotype: CCL5 and CXCL10 levels were higher in embryonic brains from Map2k7 dams versus control dams; for CCL5, this was more pronounced in Map2k7 Hz embryos.	Poly I-C	9-16	chemokine (C-C motif) ligand 5	Mus musculus	224-228
30691477-7	2019	Maternal polyI:C administration also increased embryonic brain chemokines, influenced by both maternal and embryonic genotype: CCL5 and CXCL10 levels were higher in embryonic brains from Map2k7 dams versus control dams; for CCL5, this was more pronounced in Map2k7 Hz embryos.	Poly I-C	9-16	mitogen-activated protein kinase kinase 7	Mus musculus	258-264
30691477-8	2019	Placental CXCL10 and CXCL12 levels were also elevated by polyI:C, the former enhanced and the latter suppressed, in placentae from maternal Map2k7 Hzs relative to control dams receiving polyI:C.	Poly I-C	57-64	chemokine (C-X-C motif) ligand 10	Mus musculus	10-16
30723476-6	2018	Treatment with the TLR3 ligand polyinosinic: polycytidylic acid [Poly(I:C)] did not affect GILZ mRNA levels, although GILZ protein expression was decreased.	Poly I-C	65-74	toll like receptor 3	Homo sapiens	19-23
30691477-8	2019	Placental CXCL10 and CXCL12 levels were also elevated by polyI:C, the former enhanced and the latter suppressed, in placentae from maternal Map2k7 Hzs relative to control dams receiving polyI:C.	Poly I-C	57-64	chemokine (C-X-C motif) ligand 12	Mus musculus	21-27
30723476-9	2018	Microarray analysis revealed that the expression of several potentially GILZ-targeting miRNAs was increased after Poly(I:C) treatment in primary human macrophages.	Poly I-C	114-123	TSC22 domain family member 3	Homo sapiens	72-76
30691477-8	2019	Placental CXCL10 and CXCL12 levels were also elevated by polyI:C, the former enhanced and the latter suppressed, in placentae from maternal Map2k7 Hzs relative to control dams receiving polyI:C.	Poly I-C	57-64	mitogen-activated protein kinase kinase 7	Mus musculus	140-146
30691477-8	2019	Placental CXCL10 and CXCL12 levels were also elevated by polyI:C, the former enhanced and the latter suppressed, in placentae from maternal Map2k7 Hzs relative to control dams receiving polyI:C.	Poly I-C	186-193	chemokine (C-X-C motif) ligand 10	Mus musculus	10-16
30691477-8	2019	Placental CXCL10 and CXCL12 levels were also elevated by polyI:C, the former enhanced and the latter suppressed, in placentae from maternal Map2k7 Hzs relative to control dams receiving polyI:C.	Poly I-C	186-193	chemokine (C-X-C motif) ligand 12	Mus musculus	21-27
30622241-5	2019	Similarly, administration of poly I:C only triggered increase of systemic transaminases in Ripk1LPC-KO mice, reflecting liver damage through induced apoptosis as illustrated by cleaved-caspase 3 labeling of liver tissue sections.	Poly I-C	29-37	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	91-102
30211629-6	2019	Chronic hypoxia or chronic hypoxia/SU5416 rats were treated with the TLR3 agonist polyinosinic/polycytidylic acid (Poly[I:C]).	Poly I-C	82-113	toll-like receptor 3	Rattus norvegicus	69-73
30211629-6	2019	Chronic hypoxia or chronic hypoxia/SU5416 rats were treated with the TLR3 agonist polyinosinic/polycytidylic acid (Poly[I:C]).	Poly I-C	115-124	toll-like receptor 3	Rattus norvegicus	69-73
30211629-10	2019	Poly(I:C) increased TLR3 expression via IL-10 in rat endothelial cells.	Poly I-C	0-9	toll-like receptor 3	Rattus norvegicus	20-24
30211629-10	2019	Poly(I:C) increased TLR3 expression via IL-10 in rat endothelial cells.	Poly I-C	0-9	interleukin 10	Rattus norvegicus	40-45
30621583-14	2019	The transcriptomic profile after poly(I:C)-stimulation was consistent with induction of TLR3 signalling.	Poly I-C	33-42	toll like receptor 3	Bos taurus	88-92
30218784-12	2019	Poly I:C-induced mIA did not affect litter numbers, but resulted in PD21 pup, and GD21 placenta growth restriction.	Poly I-C	0-8	MIA SH3 domain containing	Mus musculus	17-20
30082065-6	2019	METHODS: Transcript levels for NF-kappaB pathway markers were assessed using quantitative polymerase chain reaction in the prefrontal cortex from 1) 62 matched pairs of schizophrenia and unaffected comparison subjects, 2) antipsychotic-exposed monkeys, and 3) adult mice exposed prenatally to maternal immune activation or in adulthood to the immune stimulant polyinosinic-polycytidylic acid.	Poly I-C	360-391	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	31-40
30082065-8	2019	A similar pattern of elevated NF-kappaB-related messenger RNA levels was seen in adult mice that received daily polyinosinic-polycytidylic acid injections, but not in adult mice subjected to maternal immune activation in utero.	Poly I-C	112-143	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	30-39
30292753-8	2019	Medaka bcl6b could respond to the stimuli of polyI:C and LPS in the kidney and spleen.	Poly I-C	45-52	B-cell CLL/lymphoma 6 member B protein	Oryzias latipes	7-12
30172908-7	2019	Increased mRNA expression levels of PsIFN-gamma and PsGILT in PBLs were observed after induction with LPS, PolyI:C and recombinant IFN-gamma (rIFN-gamma).	Poly I-C	107-114	interferon gamma	Pelodiscus sinensis	36-47
29885990-6	2019	Indirect immunofluorescence assay (IFA) showed that over-expressed duck IRF7 was located in both the cytoplasm and nucleus of transfected duck embryo fibroblasts (DEFs), which was also observed in poly(I:C)-stimulated or duck Tembusu virus (DTMUV)-infected DEFs.	Poly I-C	197-206	interferon regulatory factor 7	Homo sapiens	72-76
29885990-8	2019	Moreover, overexpression of duck IRF7 significantly induced IFNalpha/beta, but not IFNgamma, mRNA expression, and transcription of downstream interferon-stimulated genes (ISGs), such as MX, OASL and IL-6, which were significantly induced by poly(I:C) co-stimulation, was enhanced.	Poly I-C	241-250	interferon regulatory factor 7	Homo sapiens	33-37
30172908-7	2019	Increased mRNA expression levels of PsIFN-gamma and PsGILT in PBLs were observed after induction with LPS, PolyI:C and recombinant IFN-gamma (rIFN-gamma).	Poly I-C	107-114	interferon gamma	Pelodiscus sinensis	38-47
30172908-7	2019	Increased mRNA expression levels of PsIFN-gamma and PsGILT in PBLs were observed after induction with LPS, PolyI:C and recombinant IFN-gamma (rIFN-gamma).	Poly I-C	107-114	gamma-interferon-inducible lysosomal thiol reductase	Pelodiscus sinensis	52-58
30032138-3	2019	We demonstrated that HCEs (End1/E6E7 cells) possess the functional toll-like receptor (TLR)3 signaling system, which could be activated by Poly I:C and induce multiple cellular HIV restriction factors.	Poly I-C	139-147	VPS11 core subunit of CORVET and HOPS complexes	Homo sapiens	27-31
30498026-4	2019	We demonstrated that GLDC inhibitor AOAA and siRNA depletion boosted IFNbeta- and IFN-stimulated genes (ISGs) in combination with PolyI:C stimulation.	Poly I-C	130-137	glycine decarboxylase	Homo sapiens	21-25
30528455-5	2019	RESULTS: We found that poly(I:C)-induced IFN targets Ly6C+ monocytes and impedes their transition into TAMs.	Poly I-C	23-32	lymphocyte antigen 6 complex, locus C1	Mus musculus	53-57
30321512-5	2019	Topical administration of polyinosinic-polycytidylic acid [poly (I:C)], a synthetic ligand for TLR3, to the injured cornea promoted CNV in wild type (WT) mice but not in TLR3-deficient mice.	Poly I-C	26-57	toll-like receptor 3	Mus musculus	95-99
30321512-5	2019	Topical administration of polyinosinic-polycytidylic acid [poly (I:C)], a synthetic ligand for TLR3, to the injured cornea promoted CNV in wild type (WT) mice but not in TLR3-deficient mice.	Poly I-C	59-69	toll-like receptor 3	Mus musculus	95-99
30321512-6	2019	In addition, the effect of poly (I:C) on WT mice was abolished by addition of SDF-1 receptor antagonist AMD 3100.	Poly I-C	27-37	chemokine (C-X-C motif) receptor 4	Mus musculus	78-92
30181004-6	2019	A PDE4 inhibitor was used to analyse the function of PDE4B signalling in both miR-23a and Poly(I:C)-induced PsA SFC activation.	Poly I-C	90-99	phosphodiesterase 4B	Homo sapiens	53-58
30181004-11	2019	Poly(I:C) and/or miR-23a-induced migration and enhanced cytokine expression was suppressed by the blockade of PDE4 signalling.	Poly I-C	0-8	phosphodiesterase 4A	Homo sapiens	110-114
30680935-0	2019	Bcl6aa and bcl6ab are ubiquitously expressed and are inducible by lipopolysaccharide and polyI:C in adult tissues of medaka Oryzias latipes.	Poly I-C	89-96	B-cell lymphoma 6 protein	Oryzias latipes	0-4
30032138-3	2019	We demonstrated that HCEs (End1/E6E7 cells) possess the functional toll-like receptor (TLR)3 signaling system, which could be activated by Poly I:C and induce multiple cellular HIV restriction factors.	Poly I-C	139-147	toll like receptor 3	Homo sapiens	87-90
30205169-0	2018	IFN-gamma synergism with poly I:C reduces growth of murine and human cancer cells with simultaneous changes in cell cycle and immune checkpoint proteins.	Poly I-C	25-33	interferon gamma	Mus musculus	0-9
30808838-5	2019	RESULTS: We found that poly IC induced the expression of RIG-I, MDA5 and IL-6 via TLR3/IFN-beta signaling in GECs.	Poly I-C	23-30	DExD/H-box helicase 58	Homo sapiens	57-62
30808838-5	2019	RESULTS: We found that poly IC induced the expression of RIG-I, MDA5 and IL-6 via TLR3/IFN-beta signaling in GECs.	Poly I-C	23-30	interferon induced with helicase C domain 1	Homo sapiens	64-68
30808838-5	2019	RESULTS: We found that poly IC induced the expression of RIG-I, MDA5 and IL-6 via TLR3/IFN-beta signaling in GECs.	Poly I-C	23-30	interleukin 6	Homo sapiens	73-77
30808838-5	2019	RESULTS: We found that poly IC induced the expression of RIG-I, MDA5 and IL-6 via TLR3/IFN-beta signaling in GECs.	Poly I-C	23-30	toll like receptor 3	Homo sapiens	82-86
30808838-5	2019	RESULTS: We found that poly IC induced the expression of RIG-I, MDA5 and IL-6 via TLR3/IFN-beta signaling in GECs.	Poly I-C	23-30	interferon beta 1	Homo sapiens	87-95
30373933-10	2019	Several chemokines were decreased considerably in DDX3 knockdown THP-1 cells after lipopolysaccharide or poly(I C) stimulation.	Poly I-C	105-114	DEAD-box helicase 3 X-linked	Homo sapiens	50-54
29223146-5	2018	Following autoMACS magnetic separation, CD117+/Lin-MCPs were stimulated with Poly I:C for 24hr.	Poly I-C	77-85	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	40-45
29223146-7	2018	RESULTS: There was a significant decrease in HLA-DR+/CD154- expression between CFS/ME and SM groups pre and post Poly I:C stimulation.	Poly I-C	113-121	CD40 ligand	Homo sapiens	53-58
30504422-4	2019	First, the activation of the IFN promoter stimulated by the polyinosinic-polycytidylic acid or spring viremia of carp virus was decreased by the overexpression of NDRG1a.	Poly I-C	60-91	interferon alpha 1	Homo sapiens	29-32
30622526-9	2018	The MAPK kinase inhibitor p38 diminished the formation of NETs and restored the expression of the tight junction protein claudin-5 in the mouse lung when challenged with poly I:C.	Poly I-C	170-178	mitogen-activated protein kinase 14	Mus musculus	26-29
30622526-9	2018	The MAPK kinase inhibitor p38 diminished the formation of NETs and restored the expression of the tight junction protein claudin-5 in the mouse lung when challenged with poly I:C.	Poly I-C	170-178	claudin 5	Mus musculus	121-130
30622526-10	2018	In summary, poly I:C induced the formation of pulmonary NETs and ALI, which may be associated with the activation of p38 MAPK and the decreased expression of claudin-5.	Poly I-C	12-20	mitogen-activated protein kinase 14	Mus musculus	117-120
30622526-10	2018	In summary, poly I:C induced the formation of pulmonary NETs and ALI, which may be associated with the activation of p38 MAPK and the decreased expression of claudin-5.	Poly I-C	12-20	claudin 5	Homo sapiens	158-167
30619284-3	2018	We found that LX-2 cells expressed the functional Toll-like receptor 3 (TLR3), activation of which by PolyI:C resulted in the selective induction of interferon-beta (IFN-beta) and IFN-lambdas, the phosphorylation of IFN regulatory factor 3 (IRF3) and IRF7.	Poly I-C	102-109	toll like receptor 3	Homo sapiens	50-70
30619284-3	2018	We found that LX-2 cells expressed the functional Toll-like receptor 3 (TLR3), activation of which by PolyI:C resulted in the selective induction of interferon-beta (IFN-beta) and IFN-lambdas, the phosphorylation of IFN regulatory factor 3 (IRF3) and IRF7.	Poly I-C	102-109	toll like receptor 3	Homo sapiens	72-76
30619284-3	2018	We found that LX-2 cells expressed the functional Toll-like receptor 3 (TLR3), activation of which by PolyI:C resulted in the selective induction of interferon-beta (IFN-beta) and IFN-lambdas, the phosphorylation of IFN regulatory factor 3 (IRF3) and IRF7.	Poly I-C	102-109	interferon beta 1	Homo sapiens	149-164
30619284-3	2018	We found that LX-2 cells expressed the functional Toll-like receptor 3 (TLR3), activation of which by PolyI:C resulted in the selective induction of interferon-beta (IFN-beta) and IFN-lambdas, the phosphorylation of IFN regulatory factor 3 (IRF3) and IRF7.	Poly I-C	102-109	IFN1@	Homo sapiens	166-174
30619284-3	2018	We found that LX-2 cells expressed the functional Toll-like receptor 3 (TLR3), activation of which by PolyI:C resulted in the selective induction of interferon-beta (IFN-beta) and IFN-lambdas, the phosphorylation of IFN regulatory factor 3 (IRF3) and IRF7.	Poly I-C	102-109	interferon regulatory factor 3	Homo sapiens	216-239
30619284-3	2018	We found that LX-2 cells expressed the functional Toll-like receptor 3 (TLR3), activation of which by PolyI:C resulted in the selective induction of interferon-beta (IFN-beta) and IFN-lambdas, the phosphorylation of IFN regulatory factor 3 (IRF3) and IRF7.	Poly I-C	102-109	interferon regulatory factor 3	Homo sapiens	241-245
30619284-3	2018	We found that LX-2 cells expressed the functional Toll-like receptor 3 (TLR3), activation of which by PolyI:C resulted in the selective induction of interferon-beta (IFN-beta) and IFN-lambdas, the phosphorylation of IFN regulatory factor 3 (IRF3) and IRF7.	Poly I-C	102-109	interferon regulatory factor 7	Homo sapiens	251-255
30538175-5	2018	beta4 subunit abundance was increased, and it translocated to the nucleus, in cells treated with IFN-beta, infected with dengue virus (DENV), or transfected with poly(I:C), a synthetic analog of double-stranded RNA.	Poly I-C	162-171	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	0-5
30538945-7	2018	Results: The production of IL-6 significantly increased in the presence of polyinosinic-polycytidylic acid (poly(I:C)) as the TLR3 ligand.	Poly I-C	75-106	interleukin 6	Homo sapiens	27-31
30538945-7	2018	Results: The production of IL-6 significantly increased in the presence of polyinosinic-polycytidylic acid (poly(I:C)) as the TLR3 ligand.	Poly I-C	75-106	toll like receptor 3	Homo sapiens	126-130
30538945-7	2018	Results: The production of IL-6 significantly increased in the presence of polyinosinic-polycytidylic acid (poly(I:C)) as the TLR3 ligand.	Poly I-C	108-116	interleukin 6	Homo sapiens	27-31
30538945-7	2018	Results: The production of IL-6 significantly increased in the presence of polyinosinic-polycytidylic acid (poly(I:C)) as the TLR3 ligand.	Poly I-C	108-116	toll like receptor 3	Homo sapiens	126-130
30205169-6	2018	IFN-gamma plus poly I:C, which had the most pronounced effect, decreased cyclin-D1, increased G1 cell cycle arrest, and increased Cleaved caspase-3 in B16 cells, as well as RAW264.7, a virus-transformed murine macrophage cell line.	Poly I-C	15-23	cyclin D1	Mus musculus	73-82
30320341-3	2018	The authors" recent study demonstrated that the cytotoxic effects of the RLR agonist Poly(I:C)-HMW/LyoVec  [Poly(I:C)-HMW] in human non-small cell lung cancer (NSCLC) were enhanced by cotreatment with ionizing radiation (IR).	Poly I-C	85-94	cilia and flagella associated protein 97	Homo sapiens	95-98
29870688-8	2018	Pretreatment with polyinosinic-polycytidylic acid alone or plus the antimicrobial peptide, LL37 enhanced IFN-beta production and suppressed viral replication.	Poly I-C	18-49	cathelicidin antimicrobial peptide	Homo sapiens	91-95
30320341-3	2018	The authors" recent study demonstrated that the cytotoxic effects of the RLR agonist Poly(I:C)-HMW/LyoVec  [Poly(I:C)-HMW] in human non-small cell lung cancer (NSCLC) were enhanced by cotreatment with ionizing radiation (IR).	Poly I-C	85-94	cilia and flagella associated protein 97	Homo sapiens	118-121
29870688-8	2018	Pretreatment with polyinosinic-polycytidylic acid alone or plus the antimicrobial peptide, LL37 enhanced IFN-beta production and suppressed viral replication.	Poly I-C	18-49	interferon beta 1	Homo sapiens	105-113
30320341-3	2018	The authors" recent study demonstrated that the cytotoxic effects of the RLR agonist Poly(I:C)-HMW/LyoVec  [Poly(I:C)-HMW] in human non-small cell lung cancer (NSCLC) were enhanced by cotreatment with ionizing radiation (IR).	Poly I-C	108-117	cilia and flagella associated protein 97	Homo sapiens	95-98
30320341-3	2018	The authors" recent study demonstrated that the cytotoxic effects of the RLR agonist Poly(I:C)-HMW/LyoVec  [Poly(I:C)-HMW] in human non-small cell lung cancer (NSCLC) were enhanced by cotreatment with ionizing radiation (IR).	Poly I-C	108-117	cilia and flagella associated protein 97	Homo sapiens	118-121
30320341-4	2018	Furthermore, cotreatment with Poly(I:C)-HMW and IR effectively induced cell death, including apoptosis, in a caspase-dependent manner.	Poly I-C	30-39	cilia and flagella associated protein 97	Homo sapiens	40-43
30320341-6	2018	Therefore, the pathways involved in the increase in apoptosis elicited by cotreatment with Poly(I:C)-HMW and IR in the A549 human NSCLC cell line were investigated.	Poly I-C	91-100	cilia and flagella associated protein 97	Homo sapiens	101-104
30320341-7	2018	Poly(I:C)-HMW induced the expression of active caspase-8 and -9, and the Poly(I:C)-HMW-induced increase in the cell cycle sub-G1 population, which is one of the hallmarks of apoptosis, was decreased by treatment with a caspase-8 inhibitor and caspase-9 inhibitor.	Poly I-C	0-9	cilia and flagella associated protein 97	Homo sapiens	10-13
30445257-7	2018	UVB (4.8 mJ/cm2) and Poly I:C (0.3 mug/mL) co-treatment decreased IkappaBalpha expression level in a time-dependent manner.	Poly I-C	21-29	NFKB inhibitor alpha	Homo sapiens	66-78
30320341-7	2018	Poly(I:C)-HMW induced the expression of active caspase-8 and -9, and the Poly(I:C)-HMW-induced increase in the cell cycle sub-G1 population, which is one of the hallmarks of apoptosis, was decreased by treatment with a caspase-8 inhibitor and caspase-9 inhibitor.	Poly I-C	0-9	caspase 8	Homo sapiens	47-63
30445257-15	2018	In summary, UVB and Poly I:C co-treatment activates IKKalpha and NEMO, which diminishes anti-apoptotic IkappaBalpha, resulting in enhancement of apoptosis through p73.	Poly I-C	20-28	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	52-60
30320341-7	2018	Poly(I:C)-HMW induced the expression of active caspase-8 and -9, and the Poly(I:C)-HMW-induced increase in the cell cycle sub-G1 population, which is one of the hallmarks of apoptosis, was decreased by treatment with a caspase-8 inhibitor and caspase-9 inhibitor.	Poly I-C	0-9	cilia and flagella associated protein 97	Homo sapiens	83-86
30445257-15	2018	In summary, UVB and Poly I:C co-treatment activates IKKalpha and NEMO, which diminishes anti-apoptotic IkappaBalpha, resulting in enhancement of apoptosis through p73.	Poly I-C	20-28	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	65-69
30445257-15	2018	In summary, UVB and Poly I:C co-treatment activates IKKalpha and NEMO, which diminishes anti-apoptotic IkappaBalpha, resulting in enhancement of apoptosis through p73.	Poly I-C	20-28	NFKB inhibitor alpha	Homo sapiens	103-115
30445257-15	2018	In summary, UVB and Poly I:C co-treatment activates IKKalpha and NEMO, which diminishes anti-apoptotic IkappaBalpha, resulting in enhancement of apoptosis through p73.	Poly I-C	20-28	tumor protein p73	Homo sapiens	163-166
30320341-7	2018	Poly(I:C)-HMW induced the expression of active caspase-8 and -9, and the Poly(I:C)-HMW-induced increase in the cell cycle sub-G1 population, which is one of the hallmarks of apoptosis, was decreased by treatment with a caspase-8 inhibitor and caspase-9 inhibitor.	Poly I-C	0-9	caspase 8	Homo sapiens	47-56
30320341-7	2018	Poly(I:C)-HMW induced the expression of active caspase-8 and -9, and the Poly(I:C)-HMW-induced increase in the cell cycle sub-G1 population, which is one of the hallmarks of apoptosis, was decreased by treatment with a caspase-8 inhibitor and caspase-9 inhibitor.	Poly I-C	0-9	caspase 9	Homo sapiens	243-252
30320341-7	2018	Poly(I:C)-HMW induced the expression of active caspase-8 and -9, and the Poly(I:C)-HMW-induced increase in the cell cycle sub-G1 population, which is one of the hallmarks of apoptosis, was decreased by treatment with a caspase-8 inhibitor and caspase-9 inhibitor.	Poly I-C	73-82	cilia and flagella associated protein 97	Homo sapiens	10-13
30320341-7	2018	Poly(I:C)-HMW induced the expression of active caspase-8 and -9, and the Poly(I:C)-HMW-induced increase in the cell cycle sub-G1 population, which is one of the hallmarks of apoptosis, was decreased by treatment with a caspase-8 inhibitor and caspase-9 inhibitor.	Poly I-C	73-82	cilia and flagella associated protein 97	Homo sapiens	83-86
30320341-7	2018	Poly(I:C)-HMW induced the expression of active caspase-8 and -9, and the Poly(I:C)-HMW-induced increase in the cell cycle sub-G1 population, which is one of the hallmarks of apoptosis, was decreased by treatment with a caspase-8 inhibitor and caspase-9 inhibitor.	Poly I-C	73-82	caspase 9	Homo sapiens	243-252
30320341-8	2018	When cells were treated with Poly(I:C)-HMW and IR, the sub-G1 population, and the active caspase-8 and caspase-9 expression were all increased compared with cells treated with Poly(I:C)-HMW or IR alone.	Poly I-C	29-38	cilia and flagella associated protein 97	Homo sapiens	39-42
30320341-8	2018	When cells were treated with Poly(I:C)-HMW and IR, the sub-G1 population, and the active caspase-8 and caspase-9 expression were all increased compared with cells treated with Poly(I:C)-HMW or IR alone.	Poly I-C	29-38	caspase 8	Homo sapiens	89-98
30320341-8	2018	When cells were treated with Poly(I:C)-HMW and IR, the sub-G1 population, and the active caspase-8 and caspase-9 expression were all increased compared with cells treated with Poly(I:C)-HMW or IR alone.	Poly I-C	29-38	caspase 9	Homo sapiens	103-112
30320341-8	2018	When cells were treated with Poly(I:C)-HMW and IR, the sub-G1 population, and the active caspase-8 and caspase-9 expression were all increased compared with cells treated with Poly(I:C)-HMW or IR alone.	Poly I-C	29-38	cilia and flagella associated protein 97	Homo sapiens	186-189
30320341-8	2018	When cells were treated with Poly(I:C)-HMW and IR, the sub-G1 population, and the active caspase-8 and caspase-9 expression were all increased compared with cells treated with Poly(I:C)-HMW or IR alone.	Poly I-C	176-185	cilia and flagella associated protein 97	Homo sapiens	186-189
30320341-9	2018	Furthermore, expression of X-linked inhibitor of apoptosis protein, which negatively regulates caspase activation, was decreased in cells cotreated with Poly(I:C)-HMW and IR.	Poly I-C	153-162	cilia and flagella associated protein 97	Homo sapiens	163-166
30320341-10	2018	Notably, treatment with an inhibitor for caspase-8, not caspase-9, partially reversed the net increase in the sub-G1 population induced by cotreatment with Poly(I:C)-HMW and IR.	Poly I-C	156-164	caspase 8	Homo sapiens	41-50
30320341-10	2018	Notably, treatment with an inhibitor for caspase-8, not caspase-9, partially reversed the net increase in the sub-G1 population induced by cotreatment with Poly(I:C)-HMW and IR.	Poly I-C	156-164	cilia and flagella associated protein 97	Homo sapiens	166-169
30320341-11	2018	Collectively, these results suggested that Poly(I:C)-HMW induces apoptosis through caspase-8 and caspase-9 activation; however, the apoptotic pathway mediated by casapse-8, and not casapse-9, is involved in the enhancement of apoptosis caused by cotreatment with Poly(I:C)-HMW and IR.	Poly I-C	43-52	cilia and flagella associated protein 97	Homo sapiens	53-56
30320341-11	2018	Collectively, these results suggested that Poly(I:C)-HMW induces apoptosis through caspase-8 and caspase-9 activation; however, the apoptotic pathway mediated by casapse-8, and not casapse-9, is involved in the enhancement of apoptosis caused by cotreatment with Poly(I:C)-HMW and IR.	Poly I-C	43-52	caspase 8	Homo sapiens	83-92
30320341-11	2018	Collectively, these results suggested that Poly(I:C)-HMW induces apoptosis through caspase-8 and caspase-9 activation; however, the apoptotic pathway mediated by casapse-8, and not casapse-9, is involved in the enhancement of apoptosis caused by cotreatment with Poly(I:C)-HMW and IR.	Poly I-C	43-52	caspase 9	Homo sapiens	97-106
30320341-11	2018	Collectively, these results suggested that Poly(I:C)-HMW induces apoptosis through caspase-8 and caspase-9 activation; however, the apoptotic pathway mediated by casapse-8, and not casapse-9, is involved in the enhancement of apoptosis caused by cotreatment with Poly(I:C)-HMW and IR.	Poly I-C	43-52	cilia and flagella associated protein 97	Homo sapiens	273-276
30320341-11	2018	Collectively, these results suggested that Poly(I:C)-HMW induces apoptosis through caspase-8 and caspase-9 activation; however, the apoptotic pathway mediated by casapse-8, and not casapse-9, is involved in the enhancement of apoptosis caused by cotreatment with Poly(I:C)-HMW and IR.	Poly I-C	263-272	cilia and flagella associated protein 97	Homo sapiens	53-56
30209176-6	2018	Furthermore, HOIL1 and MDA5 were required for IFN induction after Theiler"s murine encephalomyelitis virus infection and poly(I C) transfection, but not Sendai virus or vesicular stomatitis virus infection, indicating that HOIL1 and LUBAC are required selectively for MDA5 signaling.	Poly I-C	121-130	RANBP2-type and C3HC4-type zinc finger containing 1	Homo sapiens	13-18
30473353-9	2018	Furthermore, exogenous IFN-beta and polyinosinic-polycytidylic acid (poly (I:C)) treatment markedly inhibited the mRNA levels of TGEV gRNA, N and ORF7 in WT PK-15 cells and p53-/- PK-15 cells compared to control.	Poly I-C	36-67	tumor protein p53	Sus scrofa	173-176
30613299-10	2018	However, FMT combined with PIC synergistically inhibited their proliferation by shifting macrophages to a tumoricidal phenotype with upregulated TNF-alpha and iNOS, increased NO secretion and augmented phagocytosis induced by NOX2-derived ROS in vitro.	Poly I-C	27-30	tumor necrosis factor	Mus musculus	145-154
30613299-10	2018	However, FMT combined with PIC synergistically inhibited their proliferation by shifting macrophages to a tumoricidal phenotype with upregulated TNF-alpha and iNOS, increased NO secretion and augmented phagocytosis induced by NOX2-derived ROS in vitro.	Poly I-C	27-30	nitric oxide synthase 2, inducible	Mus musculus	159-163
30613299-10	2018	However, FMT combined with PIC synergistically inhibited their proliferation by shifting macrophages to a tumoricidal phenotype with upregulated TNF-alpha and iNOS, increased NO secretion and augmented phagocytosis induced by NOX2-derived ROS in vitro.	Poly I-C	27-30	cytochrome b-245, beta polypeptide	Mus musculus	226-230
30542351-12	2018	Although intradermal injection of OVA and polyinosinic-polycytidylic acid (poly(I:C)) as an adjuvant also induced CD8+ T cell responses to OVA, poly (I:C) poorly recruited XCR1+CD103+ DCs in the injection site and failed to induce significant memory CTL responses to OVA.	Poly I-C	42-73	chemokine (C motif) receptor 1	Mus musculus	172-176
30542351-12	2018	Although intradermal injection of OVA and polyinosinic-polycytidylic acid (poly(I:C)) as an adjuvant also induced CD8+ T cell responses to OVA, poly (I:C) poorly recruited XCR1+CD103+ DCs in the injection site and failed to induce significant memory CTL responses to OVA.	Poly I-C	75-84	chemokine (C motif) receptor 1	Mus musculus	172-176
30442927-7	2018	However, depletion of JNK protein using siRNA sensitized macrophages to necroptosis that was triggered by LPS or poly I:C but still inhibited TNF-induced necroptosis.	Poly I-C	113-121	mitogen-activated protein kinase 8	Mus musculus	22-25
30195920-2	2018	We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC) induces the expression of interferon (IFN)-stimulated gene 60 (ISG60), and this reaction was mediated by IFN-beta.	Poly I-C	139-170	toll like receptor 3	Homo sapiens	103-123
30195920-2	2018	We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC) induces the expression of interferon (IFN)-stimulated gene 60 (ISG60), and this reaction was mediated by IFN-beta.	Poly I-C	139-170	toll like receptor 3	Homo sapiens	125-129
30195920-2	2018	We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC) induces the expression of interferon (IFN)-stimulated gene 60 (ISG60), and this reaction was mediated by IFN-beta.	Poly I-C	139-170	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	244-249
30195920-2	2018	We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC) induces the expression of interferon (IFN)-stimulated gene 60 (ISG60), and this reaction was mediated by IFN-beta.	Poly I-C	139-170	IFN1@	Homo sapiens	286-294
30195920-2	2018	We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC) induces the expression of interferon (IFN)-stimulated gene 60 (ISG60), and this reaction was mediated by IFN-beta.	Poly I-C	172-179	toll like receptor 3	Homo sapiens	103-123
30195920-2	2018	We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC) induces the expression of interferon (IFN)-stimulated gene 60 (ISG60), and this reaction was mediated by IFN-beta.	Poly I-C	172-179	toll like receptor 3	Homo sapiens	125-129
30195920-2	2018	We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC) induces the expression of interferon (IFN)-stimulated gene 60 (ISG60), and this reaction was mediated by IFN-beta.	Poly I-C	172-179	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	244-249
30195920-2	2018	We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC) induces the expression of interferon (IFN)-stimulated gene 60 (ISG60), and this reaction was mediated by IFN-beta.	Poly I-C	172-179	IFN1@	Homo sapiens	286-294
30209176-6	2018	Furthermore, HOIL1 and MDA5 were required for IFN induction after Theiler"s murine encephalomyelitis virus infection and poly(I C) transfection, but not Sendai virus or vesicular stomatitis virus infection, indicating that HOIL1 and LUBAC are required selectively for MDA5 signaling.	Poly I-C	121-130	interferon induced with helicase C domain 1	Homo sapiens	23-27
30209176-6	2018	Furthermore, HOIL1 and MDA5 were required for IFN induction after Theiler"s murine encephalomyelitis virus infection and poly(I C) transfection, but not Sendai virus or vesicular stomatitis virus infection, indicating that HOIL1 and LUBAC are required selectively for MDA5 signaling.	Poly I-C	121-130	interferon alpha 1	Homo sapiens	46-49
30295964-4	2018	RESULTS: Poly (I:C) induced the expression of the interferon-stimulated genes (ISG) MxA, OAS2 and APOBEC3G, and the cytokines MCP-1, IL-8, IL-6, CCL20, IFNbeta and RANTES by fibroblasts from all three sites.	Poly I-C	9-19	MX dynamin like GTPase 1	Homo sapiens	84-87
30295964-4	2018	RESULTS: Poly (I:C) induced the expression of the interferon-stimulated genes (ISG) MxA, OAS2 and APOBEC3G, and the cytokines MCP-1, IL-8, IL-6, CCL20, IFNbeta and RANTES by fibroblasts from all three sites.	Poly I-C	9-19	2'-5'-oligoadenylate synthetase 2	Homo sapiens	89-93
30295964-4	2018	RESULTS: Poly (I:C) induced the expression of the interferon-stimulated genes (ISG) MxA, OAS2 and APOBEC3G, and the cytokines MCP-1, IL-8, IL-6, CCL20, IFNbeta and RANTES by fibroblasts from all three sites.	Poly I-C	9-19	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	98-106
30295964-4	2018	RESULTS: Poly (I:C) induced the expression of the interferon-stimulated genes (ISG) MxA, OAS2 and APOBEC3G, and the cytokines MCP-1, IL-8, IL-6, CCL20, IFNbeta and RANTES by fibroblasts from all three sites.	Poly I-C	9-19	C-C motif chemokine ligand 2	Homo sapiens	126-131
30295964-4	2018	RESULTS: Poly (I:C) induced the expression of the interferon-stimulated genes (ISG) MxA, OAS2 and APOBEC3G, and the cytokines MCP-1, IL-8, IL-6, CCL20, IFNbeta and RANTES by fibroblasts from all three sites.	Poly I-C	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
30295964-4	2018	RESULTS: Poly (I:C) induced the expression of the interferon-stimulated genes (ISG) MxA, OAS2 and APOBEC3G, and the cytokines MCP-1, IL-8, IL-6, CCL20, IFNbeta and RANTES by fibroblasts from all three sites.	Poly I-C	9-19	interleukin 6	Homo sapiens	139-143
30295964-4	2018	RESULTS: Poly (I:C) induced the expression of the interferon-stimulated genes (ISG) MxA, OAS2 and APOBEC3G, and the cytokines MCP-1, IL-8, IL-6, CCL20, IFNbeta and RANTES by fibroblasts from all three sites.	Poly I-C	9-19	C-C motif chemokine ligand 20	Homo sapiens	145-150
30295964-4	2018	RESULTS: Poly (I:C) induced the expression of the interferon-stimulated genes (ISG) MxA, OAS2 and APOBEC3G, and the cytokines MCP-1, IL-8, IL-6, CCL20, IFNbeta and RANTES by fibroblasts from all three sites.	Poly I-C	9-19	IFN1@	Homo sapiens	152-159
30295964-4	2018	RESULTS: Poly (I:C) induced the expression of the interferon-stimulated genes (ISG) MxA, OAS2 and APOBEC3G, and the cytokines MCP-1, IL-8, IL-6, CCL20, IFNbeta and RANTES by fibroblasts from all three sites.	Poly I-C	9-19	C-C motif chemokine ligand 5	Homo sapiens	164-170
30295964-6	2018	E2 inhibited the poly (I:C)-induced upregulation of MxA and OAS2 in EM fibroblasts, but not Cx or ECx fibroblasts.	Poly I-C	17-27	MX dynamin like GTPase 1	Homo sapiens	52-55
30295964-6	2018	E2 inhibited the poly (I:C)-induced upregulation of MxA and OAS2 in EM fibroblasts, but not Cx or ECx fibroblasts.	Poly I-C	17-27	2'-5'-oligoadenylate synthetase 2	Homo sapiens	60-64
30295964-8	2018	Conditioned media (CM) from poly (I:C)-treated or E2 -treated fibroblasts significantly reduced HIV infection of CD4+ T cells.	Poly I-C	28-38	CD4 molecule	Homo sapiens	113-116
30195050-3	2018	To elucidate this, we have used synthetic polyinosinic-polycytidylic acid [poly (I:C)] which acts as a dsRNA molecule and interacts with toll-like receptor-3 (TLR-3) of microglia cells to evoke the immune system, thus mimicking the viral infection.	Poly I-C	42-73	toll-like receptor 3	Rattus norvegicus	137-164
30281939-11	2018	Poly I:C downregulated IL-10 expression in M2 macrophages differentiated from THP-1 cells in vitro.	Poly I-C	0-8	interleukin 10	Homo sapiens	23-28
30286408-6	2018	We showed that activation of the Mitochondrial Antiviral Signalling (MAVS) pathway using the constitutively active N-terminal region of RIG-I or polyinosinic-polycytidylic acid (poly I:C) led to stimulation of duck RIG-I promoter activity.	Poly I-C	145-176	mitochondrial antiviral signaling protein	Gallus gallus	33-67
30286408-6	2018	We showed that activation of the Mitochondrial Antiviral Signalling (MAVS) pathway using the constitutively active N-terminal region of RIG-I or polyinosinic-polycytidylic acid (poly I:C) led to stimulation of duck RIG-I promoter activity.	Poly I-C	145-176	mitochondrial antiviral signaling protein	Gallus gallus	69-73
30286408-6	2018	We showed that activation of the Mitochondrial Antiviral Signalling (MAVS) pathway using the constitutively active N-terminal region of RIG-I or polyinosinic-polycytidylic acid (poly I:C) led to stimulation of duck RIG-I promoter activity.	Poly I-C	145-176	antiviral innate immune response receptor RIG-I	Anas platyrhynchos	215-220
30179292-4	2018	LGP2 expression levels were significantly increased only in NB cells without MYCN amplification, including SK-N-AS and SK-N-FI after poly (I:C) treatment in vitro and in mouse xenograft models.	Poly I-C	133-143	DEXH (Asp-Glu-X-His) box polypeptide 58	Mus musculus	0-4
30179292-5	2018	Ectopic expression of LGP2 in NB cells significantly enhanced poly (I:C)-induced NB cell death associated with downregulation of MDA5, RIG-I, MAVS and Bcl-2, as well as upregulation of Noxa and tBid.	Poly I-C	62-72	DExH-box helicase 58	Homo sapiens	22-26
30179292-5	2018	Ectopic expression of LGP2 in NB cells significantly enhanced poly (I:C)-induced NB cell death associated with downregulation of MDA5, RIG-I, MAVS and Bcl-2, as well as upregulation of Noxa and tBid.	Poly I-C	62-72	DExD/H-box helicase 58	Homo sapiens	135-140
30179292-6	2018	By immunofluorescence analyses, LGP2 localized mainly in the cytoplasm of NB cells after poly (I:C) treatment.	Poly I-C	89-99	DExH-box helicase 58	Homo sapiens	32-36
30195050-6	2018	We checked the immune activation by staining of TNF-alpha in the hippocampus and observed that poly (I:C) exposure elevated the number of TNF-alpha positive cells immediately after 12 h of infusion in one week rat and it persisted up to postnatal age of 3 and 12 weeks.	Poly I-C	95-105	tumor necrosis factor	Rattus norvegicus	48-57
30195050-6	2018	We checked the immune activation by staining of TNF-alpha in the hippocampus and observed that poly (I:C) exposure elevated the number of TNF-alpha positive cells immediately after 12 h of infusion in one week rat and it persisted up to postnatal age of 3 and 12 weeks.	Poly I-C	95-105	tumor necrosis factor	Rattus norvegicus	138-147
30564621-9	2018	In contrast, actively-induced EAE after poly I:C treatment results in full disease susceptibility of Mx1.Cre+ alpha4-integrinfl/fl mice, and the number and composition of CNS leukocytes is similar to controls.	Poly I-C	40-48	MX dynamin-like GTPase 1	Mus musculus	101-104
30564621-6	2018	Active experimental autoimmune encephalomyelitis (EAE) in Mx1.Cre+ alpha4-integrinfl/fl mice treated with poly I:C represents immune-reconstitution.	Poly I-C	106-114	MX dynamin-like GTPase 1	Mus musculus	58-61
30564621-11	2018	Poly I:C treatment results in a 2-fold increase in IFN beta transcription in the spinal cord.	Poly I-C	0-8	interferon beta 1, fibroblast	Mus musculus	51-59
30382048-5	2018	When co-injected with the immune adjuvant polyinosinic-polycytidylic acid(poly[I: C]), mXCL1-OVA peptide vaccine showed much greater antigen-specific cytotoxic T cell(CTL)response than either OVA protein plus poly(I: C)or OVA peptide plus poly(I: C).	Poly I-C	42-73	chemokine (C motif) ligand 1	Mus musculus	87-92
30349023-0	2018	Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis.	Poly I-C	60-69	tumor necrosis factor	Homo sapiens	8-11
30349023-0	2018	Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis.	Poly I-C	60-69	TNF superfamily member 12	Homo sapiens	44-49
30349023-2	2018	Notably, although CHX preferentially enhanced poly(I:C)-induced apoptosis, TWEAK enhanced primarily poly(I:C)-induced necroptosis.	Poly I-C	100-109	TNF superfamily member 12	Homo sapiens	75-80
30224514-5	2018	In this study, we have shown that polyinosinic:polycytidylic acid (polyI:C) and influenza A virus (IAV) infection increased IFN-lambda expression at mRNA and protein levels in primary cultures of normal human bronchial epithelial cells, whereas IL-17A attenuated polyI:C- or IAV-induced IFN-lambda expression.	Poly I-C	67-74	interferon alpha 1	Homo sapiens	124-127
30224514-5	2018	In this study, we have shown that polyinosinic:polycytidylic acid (polyI:C) and influenza A virus (IAV) infection increased IFN-lambda expression at mRNA and protein levels in primary cultures of normal human bronchial epithelial cells, whereas IL-17A attenuated polyI:C- or IAV-induced IFN-lambda expression.	Poly I-C	67-74	interleukin 17A	Homo sapiens	245-251
30224514-5	2018	In this study, we have shown that polyinosinic:polycytidylic acid (polyI:C) and influenza A virus (IAV) infection increased IFN-lambda expression at mRNA and protein levels in primary cultures of normal human bronchial epithelial cells, whereas IL-17A attenuated polyI:C- or IAV-induced IFN-lambda expression.	Poly I-C	67-74	interferon alpha 1	Homo sapiens	287-290
30224514-5	2018	In this study, we have shown that polyinosinic:polycytidylic acid (polyI:C) and influenza A virus (IAV) infection increased IFN-lambda expression at mRNA and protein levels in primary cultures of normal human bronchial epithelial cells, whereas IL-17A attenuated polyI:C- or IAV-induced IFN-lambda expression.	Poly I-C	263-270	interferon alpha 1	Homo sapiens	124-127
30224514-7	2018	In Western blotting analysis, we demonstrated that polyI:C and IAV infection induced STAT1 phosphorylation in normal human bronchial epithelial cells, whereas IL-17A suppressed polyI:C- or IAV-mediated STAT1 phosphorylation.	Poly I-C	51-58	signal transducer and activator of transcription 1	Homo sapiens	85-90
30224514-7	2018	In Western blotting analysis, we demonstrated that polyI:C and IAV infection induced STAT1 phosphorylation in normal human bronchial epithelial cells, whereas IL-17A suppressed polyI:C- or IAV-mediated STAT1 phosphorylation.	Poly I-C	51-58	signal transducer and activator of transcription 1	Homo sapiens	202-207
30224514-8	2018	Furthermore, we found that cotreatment with IL-17A and polyI:C or IAV infection synergistically increased suppressor of cytokine signaling (SOCS)1 and SOCS3 expression.	Poly I-C	55-62	suppressor of cytokine signaling 3	Homo sapiens	151-156
30224514-9	2018	SOCS1 small interfering RNA and SOCS3 small interfering RNA negated the inhibitory effect of IL-17A in polyI:C-induced IFN-lambda expression by restoring attenuated STAT1 phosphorylation.	Poly I-C	103-110	suppressor of cytokine signaling 1	Homo sapiens	0-5
30224514-9	2018	SOCS1 small interfering RNA and SOCS3 small interfering RNA negated the inhibitory effect of IL-17A in polyI:C-induced IFN-lambda expression by restoring attenuated STAT1 phosphorylation.	Poly I-C	103-110	suppressor of cytokine signaling 3	Homo sapiens	32-37
30224514-9	2018	SOCS1 small interfering RNA and SOCS3 small interfering RNA negated the inhibitory effect of IL-17A in polyI:C-induced IFN-lambda expression by restoring attenuated STAT1 phosphorylation.	Poly I-C	103-110	interleukin 17A	Homo sapiens	93-99
30224514-9	2018	SOCS1 small interfering RNA and SOCS3 small interfering RNA negated the inhibitory effect of IL-17A in polyI:C-induced IFN-lambda expression by restoring attenuated STAT1 phosphorylation.	Poly I-C	103-110	interferon alpha 1	Homo sapiens	119-122
30224514-9	2018	SOCS1 small interfering RNA and SOCS3 small interfering RNA negated the inhibitory effect of IL-17A in polyI:C-induced IFN-lambda expression by restoring attenuated STAT1 phosphorylation.	Poly I-C	103-110	signal transducer and activator of transcription 1	Homo sapiens	165-170
30337928-10	2018	Poly I:C, a synthetic analog of viral dsRNA, induced a TLR3-dependent increase in lung mast cell progenitors.	Poly I-C	0-8	toll-like receptor 3	Mus musculus	55-59
29688809-3	2018	Overexpression of USP7 suppressed Sendai virus and polyinosinic-polycytidylic acid and poly(deoxyadenylic-deoxythymidylic)-induced ISRE and IFN-beta activation, and enhanced virus replication.	Poly I-C	51-82	ubiquitin specific peptidase 7	Homo sapiens	18-22
30348171-11	2018	RESULTS: ACM prepared with polyI:C (polyI:C ACM) contained significantly higher Fstl1 protein than control ACM, but no increase in Fstl1 was observed in polyI:C ACM derived from Ifitm3-deficient astrocytes.	Poly I-C	27-34	follistatin-like 1	Mus musculus	80-85
30348171-11	2018	RESULTS: ACM prepared with polyI:C (polyI:C ACM) contained significantly higher Fstl1 protein than control ACM, but no increase in Fstl1 was observed in polyI:C ACM derived from Ifitm3-deficient astrocytes.	Poly I-C	36-43	follistatin-like 1	Mus musculus	80-85
30348171-13	2018	In agreement, the levels of Fstl1 increased in the hippocampus of polyI:C-treated neonatal mice.	Poly I-C	66-73	follistatin-like 1	Mus musculus	28-33
30348171-15	2018	Treatment of primary cultured hippocampal neurons with recombinant Fstl1 impaired dendritic elongation, and the deleterious effect of polyI:C ACM on dendritic elongation was attenuated by knockdown of Fstl1 in astrocytes.	Poly I-C	134-141	follistatin-like 1	Mus musculus	201-206
30348171-16	2018	CONCLUSIONS: The extracellular level of Fstl1 is regulated by Ifitm3 in astrocytes, which could be involved in polyI:C-induced neurodevelopmental impairment.	Poly I-C	111-118	follistatin-like 1	Mus musculus	40-45
30348171-16	2018	CONCLUSIONS: The extracellular level of Fstl1 is regulated by Ifitm3 in astrocytes, which could be involved in polyI:C-induced neurodevelopmental impairment.	Poly I-C	111-118	interferon induced transmembrane protein 3	Mus musculus	62-68
30269986-4	2018	Lipopolysaccharide (LPS)- or Poly(I:C)-treated pericyte culture medium induced similar effects in a CCL2-dependent manner.	Poly I-C	29-38	chemokine (C-C motif) ligand 2	Mus musculus	100-104
30349642-0	2018	The double stranded RNA analog poly-IC elicits both robust IFN-lambda production and oncolytic activity in human gastrointestinal cancer cells.	Poly I-C	31-38	interferon alpha 1	Homo sapiens	59-69
30349642-5	2018	Results: Poly-IC induced in all cell lines except Jurkat both a robust IFN-lambda secretion and a cytoreductive effect on adherent cells, restricted to proliferating cells and associated with cellular shedding and reduced clonogenicity of the shed cells.	Poly I-C	9-16	interferon alpha 1	Homo sapiens	71-81
30349642-9	2018	Conclusion: Our demonstration that poly-IC-induced concomitant recapitulation of two innate functions of normal intestine, i.e. IFN-lambda production and cell death, by human gastrointestinal cancer cells opens new perspectives in gastrointestinal cancer treatment.	Poly I-C	35-42	interferon alpha 1	Homo sapiens	128-138
30045970-5	2018	We found that following an IFN-inducing stimulus such as viral infection or polyI:C, programmed cell death ligand 1 (PD-L1) expression is dynamically upregulated on lymphatic endothelial cells (LECs).	Poly I-C	76-83	CD274 antigen	Mus musculus	85-115
30045970-5	2018	We found that following an IFN-inducing stimulus such as viral infection or polyI:C, programmed cell death ligand 1 (PD-L1) expression is dynamically upregulated on lymphatic endothelial cells (LECs).	Poly I-C	76-83	CD274 antigen	Mus musculus	117-122
29856997-9	2018	Additionally, the in vitro stimulation of a PAM cell line with PolyI:C for 12 and 24 h resulted in increased LMP2, LMP7, and MECL-1 expression.	Poly I-C	63-70	proteasome 20S subunit beta 9	Sus scrofa	109-113
30032173-3	2018	Here, we showed that poly IC is a potent inducer of Peli1 protein in mouse splenic B cells in dose- and time-dependent manners, and poly IC-induced Peli1 protein dramatically suppressed the activation of noncanonical NF-kappaB pathway.	Poly I-C	21-28	pellino 1	Mus musculus	52-57
30032173-3	2018	Here, we showed that poly IC is a potent inducer of Peli1 protein in mouse splenic B cells in dose- and time-dependent manners, and poly IC-induced Peli1 protein dramatically suppressed the activation of noncanonical NF-kappaB pathway.	Poly I-C	132-139	pellino 1	Mus musculus	148-153
30032173-6	2018	Our findings demonstrate that poly IC-induced Peli1 negatively regulates the noncanonical NF-kappaB pathway in the context of restraining the pathogenesis of lupus-like disease.	Poly I-C	30-37	pellino 1	Mus musculus	46-51
29933111-7	2018	Moreover, we found that On-TRAF6 was involved immune response of Nile tilapia following the stimulation with Streptococcus agalactiae and polyinosinic: polycytidylic acid (Poly I:C) when determined by using qPCR.	Poly I-C	138-170	TNF receptor-associated factor 6	Oreochromis niloticus	27-32
29603875-2	2018	We observed that TLR2/2 agonist HKLM and TLR3 agonist Poly(I:C) increased the amount of extracellular melanin from primary human epidermal melanocytes.	Poly I-C	54-62	toll like receptor 3	Homo sapiens	41-45
29856997-9	2018	Additionally, the in vitro stimulation of a PAM cell line with PolyI:C for 12 and 24 h resulted in increased LMP2, LMP7, and MECL-1 expression.	Poly I-C	63-70	proteasome 20S subunit beta 8	Sus scrofa	115-119
29870743-7	2018	However, all the liposomal groups containing both DT and poly(I:C) showed enhanced IgG2a titers compared to DT/poly(I:C) solution, indicating that the immune response was skewed towards a Th1 direction.	Poly I-C	57-65	immunoglobulin heavy variable V1-9	Mus musculus	83-88
29853604-5	2018	Induction of CTL-attractants by either poly I:C or rintatolimod was further enhanced by exogenous IFNalpha (enhancer of TLR3 expression), whereas COX2 inhibition enhanced the response to poly-I:C only.	Poly I-C	39-47	interferon alpha 1	Homo sapiens	98-106
29738048-0	2018	Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes.	Poly I-C	30-61	carbonic anhydrase 2	Homo sapiens	75-96
29738048-4	2018	A significant upregulation of carbonic anhydrase II at the mRNA and protein levels was observed upon treatment with polyinosinic-polycytidylic acid, a toll-like receptor 3 agonist.	Poly I-C	116-147	carbonic anhydrase 2	Homo sapiens	30-51
29959281-6	2018	Specifically, the response to poly I:C (mimicking viral dsRNA and signaling through TLR3) induced a distinct RELA profile, binding in the vicinity of antiviral genes and correlating with corresponding gene expression.	Poly I-C	30-38	toll like receptor 3	Homo sapiens	84-88
29959281-6	2018	Specifically, the response to poly I:C (mimicking viral dsRNA and signaling through TLR3) induced a distinct RELA profile, binding in the vicinity of antiviral genes and correlating with corresponding gene expression.	Poly I-C	30-38	RELA proto-oncogene, NF-kB subunit	Homo sapiens	109-113
30150992-7	2018	We confirmed that TRIM14 is an ISG in the hepatic cells, and that the pattern-recognition receptor ligands polyI:C and polydAdT induce TRIM14 dependent on IFN-I production.	Poly I-C	107-114	tripartite motif containing 14	Homo sapiens	135-141
30150992-7	2018	We confirmed that TRIM14 is an ISG in the hepatic cells, and that the pattern-recognition receptor ligands polyI:C and polydAdT induce TRIM14 dependent on IFN-I production.	Poly I-C	107-114	interferon alpha 1	Homo sapiens	155-160
30246036-6	2018	TLR3 agonist (Poly I:C) increased IFN-gamma and IL-4 levels in the supernatant of cultured splenocytes and induced a higher percentage of IFN-gamma- and IL-4-secreting NK cells from infected mouse splenocytes (P &lt; 0.05).	Poly I-C	14-22	toll-like receptor 3	Mus musculus	0-4
30246036-6	2018	TLR3 agonist (Poly I:C) increased IFN-gamma and IL-4 levels in the supernatant of cultured splenocytes and induced a higher percentage of IFN-gamma- and IL-4-secreting NK cells from infected mouse splenocytes (P &lt; 0.05).	Poly I-C	14-22	interferon gamma	Mus musculus	34-43
30246036-6	2018	TLR3 agonist (Poly I:C) increased IFN-gamma and IL-4 levels in the supernatant of cultured splenocytes and induced a higher percentage of IFN-gamma- and IL-4-secreting NK cells from infected mouse splenocytes (P &lt; 0.05).	Poly I-C	14-22	interleukin 4	Mus musculus	48-52
30246036-6	2018	TLR3 agonist (Poly I:C) increased IFN-gamma and IL-4 levels in the supernatant of cultured splenocytes and induced a higher percentage of IFN-gamma- and IL-4-secreting NK cells from infected mouse splenocytes (P &lt; 0.05).	Poly I-C	14-22	interferon gamma	Mus musculus	138-147
30246036-6	2018	TLR3 agonist (Poly I:C) increased IFN-gamma and IL-4 levels in the supernatant of cultured splenocytes and induced a higher percentage of IFN-gamma- and IL-4-secreting NK cells from infected mouse splenocytes (P &lt; 0.05).	Poly I-C	14-22	interleukin 4	Mus musculus	153-157
29973480-5	2018	In addition, we examined tissue expression patterns, inducibilities of the feline MDA5 by polyinosinic-polycytidylic acid and type I IFN, and a functional role of feline MDA5 on type I IFN expression.	Poly I-C	90-121	interferon induced with helicase C domain 1	Homo sapiens	82-86
29853604-5	2018	Induction of CTL-attractants by either poly I:C or rintatolimod was further enhanced by exogenous IFNalpha (enhancer of TLR3 expression), whereas COX2 inhibition enhanced the response to poly-I:C only.	Poly I-C	187-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-150
29879406-13	2018	PolyI:C stimulated BMM of Tlr3-/- mice showed a reduction of Ifit1 (p = 0.003) and Mx1 (p &lt; 0.0001) mRNA compared to control.	Poly I-C	0-7	toll-like receptor 3	Mus musculus	26-30
29509510-0	2018	Epicutaneous administration of the pattern recognition receptor agonist polyinosinic-polycytidylic acid activates the MDA5/MAVS pathway in Langerhans cells.	Poly I-C	72-103	interferon induced with helicase C domain 1	Homo sapiens	118-122
29509510-0	2018	Epicutaneous administration of the pattern recognition receptor agonist polyinosinic-polycytidylic acid activates the MDA5/MAVS pathway in Langerhans cells.	Poly I-C	72-103	mitochondrial antiviral signaling protein	Homo sapiens	123-127
29509510-9	2018	Our data suggest that MDA5 may be an attractive adjuvant target for epicutaneous delivery of therapeutic vaccines with the goal to target LCs.-Tajpara, P., Schuster, C., Schon, E., Kienzl, P., Vierhapper, M., Mildner, M., Elbe-Burger, A. Epicutaneous administration of the pattern recognition receptor agonist polyinosinic-polycytidylic acid activates the MDA5/MAVS pathway in Langerhans cells.	Poly I-C	310-341	interferon induced with helicase C domain 1	Homo sapiens	22-26
29879406-13	2018	PolyI:C stimulated BMM of Tlr3-/- mice showed a reduction of Ifit1 (p = 0.003) and Mx1 (p &lt; 0.0001) mRNA compared to control.	Poly I-C	0-7	interferon-induced protein with tetratricopeptide repeats 1	Mus musculus	61-66
29879406-13	2018	PolyI:C stimulated BMM of Tlr3-/- mice showed a reduction of Ifit1 (p = 0.003) and Mx1 (p &lt; 0.0001) mRNA compared to control.	Poly I-C	0-7	MX dynamin-like GTPase 1	Mus musculus	83-86
30063728-7	2018	We found that addition of the TLR3 agonist, polyinosinic:polycytidylic acid (Poly(I:C)) to either one of the Mincle receptor agonists, TDB or monomycoloyl glycerol (MMG), enhanced monocyte activation, and calves vaccinated with CAF09 containing MMG and Poly(I:C) had increased cell-mediated and humoral immune response compared to CAF01 vaccinated animals.	Poly I-C	77-85	toll like receptor 3	Bos taurus	30-34
30063728-7	2018	We found that addition of the TLR3 agonist, polyinosinic:polycytidylic acid (Poly(I:C)) to either one of the Mincle receptor agonists, TDB or monomycoloyl glycerol (MMG), enhanced monocyte activation, and calves vaccinated with CAF09 containing MMG and Poly(I:C) had increased cell-mediated and humoral immune response compared to CAF01 vaccinated animals.	Poly I-C	77-85	C-type lectin domain family 4 member E	Bos taurus	109-115
30054566-7	2018	Stimulation with Poly (I:C) LMW induced a 15 to 17 fold increase in IL-6 production by HNEC-ALI control cells (p &lt; 0.05) and HNEC-ALI-CRS cells (p = 0.004) whilst a 2.5 fold increase was observed in CRS HNEC submerged cultures.	Poly I-C	17-31	interleukin 6	Homo sapiens	68-72
30054566-8	2018	Priming of cells with Poly (I:C) LMW reduced subsequent IL-6 secretion upon stimulation with TLR 2-4 agonists.	Poly I-C	22-36	interleukin 6	Homo sapiens	56-60
30054566-0	2018	Primary human nasal epithelial cells: a source of poly (I:C) LMW-induced IL-6 production.	Poly I-C	50-64	interleukin 6	Homo sapiens	73-77
29747051-5	2018	In rIL-4/13 pre-stimulated cells, the viral PAMPS polyI:C and R848 had the most pronounced effect on BATF3 expression.	Poly I-C	50-57	interleukin 4	Rattus norvegicus	3-8
30038210-2	2018	We tested the hypothesis that dysbindin-1 (Dtnbp1) gene mutation combined with postnatal exposure to viral mimetic polyI:C results in schizophrenia-related behavioural changes in adulthood, and mediates polyI:C-induced inflammation in the subventricular zone (SVZ).	Poly I-C	203-210	dystrobrevin binding protein 1	Mus musculus	30-41
30038210-2	2018	We tested the hypothesis that dysbindin-1 (Dtnbp1) gene mutation combined with postnatal exposure to viral mimetic polyI:C results in schizophrenia-related behavioural changes in adulthood, and mediates polyI:C-induced inflammation in the subventricular zone (SVZ).	Poly I-C	203-210	dystrobrevin binding protein 1	Mus musculus	43-49
30038210-3	2018	Adult Sandy (Sdy, Dtnbp1 mutant) mice given early postnatal polyI:C injections displayed reduced prepulse inhibition of startle, reduced locomotion and deficits in novel object recognition.	Poly I-C	60-67	dystrobrevin binding protein 1	Mus musculus	18-24
30038210-4	2018	PolyI:C induced a canonical immune response in the SVZ; it increased mRNA expression of its toll-like receptor 3 (Tlr3) and downstream transcription factors RelA and Sp1.	Poly I-C	0-7	toll-like receptor 3	Mus musculus	92-112
30038210-4	2018	PolyI:C induced a canonical immune response in the SVZ; it increased mRNA expression of its toll-like receptor 3 (Tlr3) and downstream transcription factors RelA and Sp1.	Poly I-C	0-7	toll-like receptor 3	Mus musculus	114-118
30038210-4	2018	PolyI:C induced a canonical immune response in the SVZ; it increased mRNA expression of its toll-like receptor 3 (Tlr3) and downstream transcription factors RelA and Sp1.	Poly I-C	0-7	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	157-161
30038210-5	2018	PolyI:C also increased SVZ Dtnbp1 mRNA expression, suggesting dysbindin-1 regulates immune responses.	Poly I-C	0-7	dystrobrevin binding protein 1	Mus musculus	27-33
30038210-5	2018	PolyI:C also increased SVZ Dtnbp1 mRNA expression, suggesting dysbindin-1 regulates immune responses.	Poly I-C	0-7	dystrobrevin binding protein 1	Mus musculus	62-73
30038210-6	2018	Dysbindin-1 loss in Sdy mice blocked the polyI:C-induced increases in mRNA expression of Tlr3, RelA and Sp1 in the SVZ.	Poly I-C	41-48	dystrobrevin binding protein 1	Mus musculus	0-11
30038210-6	2018	Dysbindin-1 loss in Sdy mice blocked the polyI:C-induced increases in mRNA expression of Tlr3, RelA and Sp1 in the SVZ.	Poly I-C	41-48	toll-like receptor 3	Mus musculus	89-93
30038210-6	2018	Dysbindin-1 loss in Sdy mice blocked the polyI:C-induced increases in mRNA expression of Tlr3, RelA and Sp1 in the SVZ.	Poly I-C	41-48	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	95-99
30038210-9	2018	PolyI:C did not alter SVZ Iba1+ cell density but increased CD45+/Iba1- cell numbers in the SVZ of Sdy mice.	Poly I-C	0-7	induction of brown adipocytes 1	Mus musculus	65-69
29702280-8	2018	Poly(I: C) stimulation resulted in robust increase of IL-8, IL-6, and TNF-alpha by CD14+ monocytes in severe HFMD compared to NC.	Poly I-C	0-9	CD14 molecule	Homo sapiens	83-87
29674236-0	2018	Sub-lethal ultraviolet B irradiation and Poly I:C treatment synergistically induced apoptosis of HaCaT cells through NF-kappaB pathway.	Poly I-C	41-49	nuclear factor kappa B subunit 1	Homo sapiens	117-126
29674236-5	2018	Poly I:C, an analogue of dsRNA that activates TLR3, was used in combination with sub-lethal UVB (4.8 mJ/cm2) irradiation for investigating the effects of TLR3 activation on human immortalized keratinocyte HaCaT cells.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	46-50
30042304-8	2018	Fkbp5 and Nr3c1 expression were lower in the Cnr2 heterozygotes than in the wild type mice with Poly I:C treatment.	Poly I-C	96-104	FK506 binding protein 5	Mus musculus	0-5
30042304-8	2018	Fkbp5 and Nr3c1 expression were lower in the Cnr2 heterozygotes than in the wild type mice with Poly I:C treatment.	Poly I-C	96-104	nuclear receptor subfamily 3, group C, member 1	Mus musculus	10-15
30042304-8	2018	Fkbp5 and Nr3c1 expression were lower in the Cnr2 heterozygotes than in the wild type mice with Poly I:C treatment.	Poly I-C	96-104	cannabinoid receptor 2 (macrophage)	Mus musculus	45-49
29769269-2	2018	In this study, we found the E3 ligase TRIM29 was specifically expressed in poly I:C-stimulated human myeloid dendritic cells.	Poly I-C	75-83	tripartite motif containing 29	Homo sapiens	38-44
29769269-3	2018	The induced TRIM29 played a negative role in type I IFN production in response to poly I:C or dsRNA virus reovirus infection.	Poly I-C	82-90	tripartite motif-containing 29	Mus musculus	12-18
29669207-4	2018	Poly I:C (PIC, a TLR3 agonist)-loaded ZnPP PM (ZnPP PM/PIC) efficiently repolarized TAMs to M1 macrophages, which were reliant on ROS generation.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	17-21
29940963-6	2018	RESULTS: TBEC and AMs showed stronger pro-inflammatory cytokine (e.g., IL-8) responses to PIC and LPS, respectively.	Poly I-C	90-93	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
29940963-8	2018	However, PIC stimulation in AMs led to sustained up-regulation of the immune negative regulators Tollip and A20, which may render AMs less sensitive to PIC stimulation than TBEC.	Poly I-C	9-12	toll interacting protein	Homo sapiens	97-103
29940963-8	2018	However, PIC stimulation in AMs led to sustained up-regulation of the immune negative regulators Tollip and A20, which may render AMs less sensitive to PIC stimulation than TBEC.	Poly I-C	9-12	immunoglobulin kappa variable 1-27	Homo sapiens	108-111
29940963-11	2018	PIC-stimulated TBEC and LPS-stimulated AMs from smokers vs. non-smokers produced more IL-8.	Poly I-C	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
29799636-3	2018	In this study, polyinosinic:polycytidylic acid [poly(I:C)], the ligand of TLR3, was considered as the potential adjuvant for vaccines targeting stronger Th1-based immune responses.	Poly I-C	15-46	toll-like receptor 3	Mus musculus	74-78
29799636-3	2018	In this study, polyinosinic:polycytidylic acid [poly(I:C)], the ligand of TLR3, was considered as the potential adjuvant for vaccines targeting stronger Th1-based immune responses.	Poly I-C	15-46	negative elongation factor complex member C/D, Th1l	Mus musculus	153-156
29799636-3	2018	In this study, polyinosinic:polycytidylic acid [poly(I:C)], the ligand of TLR3, was considered as the potential adjuvant for vaccines targeting stronger Th1-based immune responses.	Poly I-C	48-57	toll-like receptor 3	Mus musculus	74-78
29799636-3	2018	In this study, polyinosinic:polycytidylic acid [poly(I:C)], the ligand of TLR3, was considered as the potential adjuvant for vaccines targeting stronger Th1-based immune responses.	Poly I-C	48-57	negative elongation factor complex member C/D, Th1l	Mus musculus	153-156
29669207-4	2018	Poly I:C (PIC, a TLR3 agonist)-loaded ZnPP PM (ZnPP PM/PIC) efficiently repolarized TAMs to M1 macrophages, which were reliant on ROS generation.	Poly I-C	10-13	toll like receptor 3	Homo sapiens	17-21
29452288-4	2018	Polyinosinic-polycytidylic acid [poly(I:C)] mimics double stranded RNA and has been shown to activate TLR3.	Poly I-C	0-31	toll-like receptor 3	Mus musculus	102-106
29609027-0	2018	Identification, characterization and expression analysis of MAVS in Pelodiscus sinensis after challenge with Poly I:C.	Poly I-C	109-117	mitochondrial antiviral-signaling protein	Pelodiscus sinensis	60-64
29410345-11	2018	Exposure to IFNI or to its inducer polyinosinic-polycytidylic acid, restores ISG expression and insulin sensitivity in OIR myotubes and OIS myotubes transfected with siRNF41.	Poly I-C	35-66	insulin	Homo sapiens	96-103
29583060-11	2018	CONCLUSIONS: PAPep attenuates the expression of inflammatory cytokines and ICAM-1 in corneal fibroblasts induced by poly(I:C) through blocking the NF-kappaB and MAPK(p38) pathway.	Poly I-C	116-125	intercellular adhesion molecule 1	Homo sapiens	75-81
29583060-11	2018	CONCLUSIONS: PAPep attenuates the expression of inflammatory cytokines and ICAM-1 in corneal fibroblasts induced by poly(I:C) through blocking the NF-kappaB and MAPK(p38) pathway.	Poly I-C	116-125	nuclear factor kappa B subunit 1	Homo sapiens	147-156
29583060-11	2018	CONCLUSIONS: PAPep attenuates the expression of inflammatory cytokines and ICAM-1 in corneal fibroblasts induced by poly(I:C) through blocking the NF-kappaB and MAPK(p38) pathway.	Poly I-C	116-125	mitogen-activated protein kinase 14	Homo sapiens	161-170
29632236-2	2018	Cannabinoid type-2 (CB2) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD).	Poly I-C	139-170	cannabinoid receptor 2	Homo sapiens	0-18
29632236-2	2018	Cannabinoid type-2 (CB2) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD).	Poly I-C	139-170	cannabinoid receptor 2	Homo sapiens	20-23
29632236-2	2018	Cannabinoid type-2 (CB2) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD).	Poly I-C	139-170	C-C motif chemokine ligand 8	Homo sapiens	87-117
29632236-2	2018	Cannabinoid type-2 (CB2) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD).	Poly I-C	139-170	C-C motif chemokine ligand 8	Homo sapiens	119-124
29505789-4	2018	Synaptically driven spontaneous action potential (AP) firing was significantly reduced by the TLR3 specific activator, poly I:C, in a concentration-dependent manner following both short (5 min) and long exposures (1h) in rat hippocampal cultures.	Poly I-C	119-127	toll-like receptor 3	Rattus norvegicus	94-98
29505789-5	2018	Notably, the consequence of TLR3 activation on neuronal function was reproduced in iPSC-derived cortical neurons, with poly I:C (25 mug/ml, 1h) significantly inhibiting sAP firing.	Poly I-C	119-127	toll like receptor 3	Homo sapiens	28-32
29505789-5	2018	Notably, the consequence of TLR3 activation on neuronal function was reproduced in iPSC-derived cortical neurons, with poly I:C (25 mug/ml, 1h) significantly inhibiting sAP firing.	Poly I-C	119-127	SH2 domain containing 1A	Homo sapiens	169-172
29505789-6	2018	We examined the mechanisms underlying these effects, with poly I:C significantly reducing peak sodium current, an effect dependent on the MyD88-independent TRIF dependent pathway.	Poly I-C	58-66	MYD88 innate immune signal transduction adaptor	Homo sapiens	138-143
29505789-6	2018	We examined the mechanisms underlying these effects, with poly I:C significantly reducing peak sodium current, an effect dependent on the MyD88-independent TRIF dependent pathway.	Poly I-C	58-66	TIR domain containing adaptor molecule 1	Homo sapiens	156-160
29470604-5	2018	Splenocytes prepared from immunized CatH-/- showed a significant decrease in poly(I:C)-induced increased TLR3 expression, interferon regulatory factor 3 (IRF3) phospholylation and IFN-beta secretion.	Poly I-C	77-86	cathepsin H	Mus musculus	36-40
29962372-0	2018	Hypothiocyanous Acid Suppresses PolyI:C-Induced Antiviral Responses by Modulating IRF3 Phosphorylation in Human Airway Epithelial Cells.	Poly I-C	32-39	interferon regulatory factor 3	Homo sapiens	82-86
28421993-3	2018	Poly(I:C)-induced IL-28A and IL-29 expressions were determined in immortalized human salivary gland acinar (NS-SV-AC) and ductal (NS-SV-DC) cell lines.	Poly I-C	0-8	interferon lambda 2	Homo sapiens	18-24
28421993-3	2018	Poly(I:C)-induced IL-28A and IL-29 expressions were determined in immortalized human salivary gland acinar (NS-SV-AC) and ductal (NS-SV-DC) cell lines.	Poly I-C	0-8	interferon lambda 1	Homo sapiens	29-34
28421993-7	2018	Poly(I:C) treatment led to the induction of IL-28A and IL-29 in the salivary gland cell lines.	Poly I-C	0-8	interferon lambda 2	Homo sapiens	44-50
28421993-7	2018	Poly(I:C) treatment led to the induction of IL-28A and IL-29 in the salivary gland cell lines.	Poly I-C	0-8	interferon lambda 1	Homo sapiens	55-60
29400409-6	2018	While MerTK blocking antibody uniformly suppressed apoptotic cell uptake by MDMs, Axl blocking antibody significantly reduced efferocytosis by poly(I:C)-stimulated MDMs, but not by resting MDMs.	Poly I-C	143-152	AXL receptor tyrosine kinase	Homo sapiens	82-85
29673285-6	2018	We found robust Th1 polarizing IL-12p70, IFN-gamma and IFN-alpha responses when cord blood APCs were stimulated with TLR agonist combinations that contained Poly I:C, Monophosphoryl Lipid A (MPLA) or R848.	Poly I-C	157-165	negative elongation factor complex member C/D	Homo sapiens	16-19
29632147-7	2018	Moreover, IRF3 activation by polyinosinic-polycytidylic acid augmented TNF-alpha-induced CCL2 secretion.	Poly I-C	29-60	interferon regulatory factor 3	Homo sapiens	10-14
29632147-7	2018	Moreover, IRF3 activation by polyinosinic-polycytidylic acid augmented TNF-alpha-induced CCL2 secretion.	Poly I-C	29-60	tumor necrosis factor	Homo sapiens	71-80
29632147-7	2018	Moreover, IRF3 activation by polyinosinic-polycytidylic acid augmented TNF-alpha-induced CCL2 secretion.	Poly I-C	29-60	C-C motif chemokine ligand 2	Homo sapiens	89-93
29720226-8	2018	We identified that Peli1 mRNA levels were significantly reduced in PolyI:C- and lipopolysaccharide (LPS)-stimulated bid-deficient microglia, suggesting disturbed IRF3 activation.	Poly I-C	67-74	pellino E3 ubiquitin protein ligase 1	Homo sapiens	19-24
29720226-8	2018	We identified that Peli1 mRNA levels were significantly reduced in PolyI:C- and lipopolysaccharide (LPS)-stimulated bid-deficient microglia, suggesting disturbed IRF3 activation.	Poly I-C	67-74	BH3 interacting domain death agonist	Homo sapiens	116-119
29470604-5	2018	Splenocytes prepared from immunized CatH-/- showed a significant decrease in poly(I:C)-induced increased TLR3 expression, interferon regulatory factor 3 (IRF3) phospholylation and IFN-beta secretion.	Poly I-C	77-86	toll-like receptor 3	Mus musculus	105-109
29470604-5	2018	Splenocytes prepared from immunized CatH-/- showed a significant decrease in poly(I:C)-induced increased TLR3 expression, interferon regulatory factor 3 (IRF3) phospholylation and IFN-beta secretion.	Poly I-C	77-86	interferon regulatory factor 3	Mus musculus	122-152
29470604-5	2018	Splenocytes prepared from immunized CatH-/- showed a significant decrease in poly(I:C)-induced increased TLR3 expression, interferon regulatory factor 3 (IRF3) phospholylation and IFN-beta secretion.	Poly I-C	77-86	interferon regulatory factor 3	Mus musculus	154-158
29470604-5	2018	Splenocytes prepared from immunized CatH-/- showed a significant decrease in poly(I:C)-induced increased TLR3 expression, interferon regulatory factor 3 (IRF3) phospholylation and IFN-beta secretion.	Poly I-C	77-86	interferon beta 1, fibroblast	Mus musculus	180-188
29636491-8	2018	Poly(I:C)-dependent ATP release was reduced by TBK-1 block and in TRPML1-/- cells, while TRPML activation with ML-SA1 was sufficient to release both ATP and acid phosphatase.	Poly I-C	0-9	TANK binding kinase 1	Homo sapiens	47-52
29395576-0	2018	Reduced-HMGB1 suppresses poly(I:C)-induced inflammation in keratinocytes.	Poly I-C	25-34	high mobility group box 1	Homo sapiens	8-13
29496994-4	2018	We found that intracellular poly(I C) transfection to mimic viral infection enhances the RIG-I/MDA5 (melanoma differentiation-associated gene 5)-mediated dimerization of interferon regulatory factor 3 (IRF-3).	Poly I-C	28-37	DExD/H-box helicase 58	Homo sapiens	89-94
29496994-4	2018	We found that intracellular poly(I C) transfection to mimic viral infection enhances the RIG-I/MDA5 (melanoma differentiation-associated gene 5)-mediated dimerization of interferon regulatory factor 3 (IRF-3).	Poly I-C	28-37	interferon induced with helicase C domain 1	Homo sapiens	95-99
29496994-4	2018	We found that intracellular poly(I C) transfection to mimic viral infection enhances the RIG-I/MDA5 (melanoma differentiation-associated gene 5)-mediated dimerization of interferon regulatory factor 3 (IRF-3).	Poly I-C	28-37	interferon induced with helicase C domain 1	Homo sapiens	101-143
29496994-4	2018	We found that intracellular poly(I C) transfection to mimic viral infection enhances the RIG-I/MDA5 (melanoma differentiation-associated gene 5)-mediated dimerization of interferon regulatory factor 3 (IRF-3).	Poly I-C	28-37	interferon regulatory factor 3	Homo sapiens	170-200
29496994-4	2018	We found that intracellular poly(I C) transfection to mimic viral infection enhances the RIG-I/MDA5 (melanoma differentiation-associated gene 5)-mediated dimerization of interferon regulatory factor 3 (IRF-3).	Poly I-C	28-37	interferon regulatory factor 3	Homo sapiens	202-207
29512705-5	2018	Poly(I:C) transfection in NSCLC cells triggered apoptosis via the extrinsic apoptotic pathway, and activated the innate immune response by promoting interferon-beta and C-X-C motif chemokine ligand 10 expression.	Poly I-C	0-8	interferon beta 1	Homo sapiens	149-164
29395576-5	2018	An immunoprecipitation was performed to know whether HMGB1 could bind to poly(I:C), and immunofluorescence staining and flow cytometric analysis were performed to check whether reduced-HMGB interferes with cellular uptake of poly(I:C) translocation (possibly by endocytosis).	Poly I-C	73-81	high mobility group box 1	Homo sapiens	53-58
29395576-5	2018	An immunoprecipitation was performed to know whether HMGB1 could bind to poly(I:C), and immunofluorescence staining and flow cytometric analysis were performed to check whether reduced-HMGB interferes with cellular uptake of poly(I:C) translocation (possibly by endocytosis).	Poly I-C	73-82	high mobility group box 1	Homo sapiens	53-58
29395576-6	2018	RESULTS: Application of exogenous HMGB1 before, but not after, exerted a suppressive effect on poly(I:C)-induced inflammation in NHKs.	Poly I-C	95-104	high mobility group box 1	Homo sapiens	34-39
29395576-7	2018	In addition, reduced-HMGB1, but not disulfide-HMGB1, exerted a suppressive effect on poly(I:C)-induced inflammation in NHKs, suggesting the importance of the redox status of exogenous HMGB1.	Poly I-C	85-94	high mobility group box 1	Homo sapiens	21-26
29395576-11	2018	CONCLUSION: These findings suggest that pre-treatment with reduced-HMGB1 ameliorates poly(I:C)-mediated inflammation in NHKs.	Poly I-C	85-94	high mobility group box 1	Homo sapiens	67-72
29636491-8	2018	Poly(I:C)-dependent ATP release was reduced by TBK-1 block and in TRPML1-/- cells, while TRPML activation with ML-SA1 was sufficient to release both ATP and acid phosphatase.	Poly I-C	0-9	mucolipin TRP cation channel 1	Homo sapiens	66-72
29465830-6	2018	Herein pre-administration of the double-stranded RNA, polyinosinic-polycytidylic acid (polyI:C), in conjunction with radiotherapy, was shown to foster tumor suppression in mice bearing radioresistant, ovalbumin-expressing Lewis lung carcinoma (LLC).	Poly I-C	54-85	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	201-210
29465830-6	2018	Herein pre-administration of the double-stranded RNA, polyinosinic-polycytidylic acid (polyI:C), in conjunction with radiotherapy, was shown to foster tumor suppression in mice bearing radioresistant, ovalbumin-expressing Lewis lung carcinoma (LLC).	Poly I-C	87-94	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	201-210
29465830-10	2018	PolyI:C targeted Toll-like receptor 3 with minimal effect on the mitochondrial antiviral-signaling protein pathway.	Poly I-C	0-7	toll-like receptor 3	Mus musculus	17-37
29397427-3	2018	Poly(I:C) is a potent Th1 inducer and a human compatible adjuvant capable of stimulating both B- and T-cell immunity.	Poly I-C	0-8	negative elongation factor complex member C/D	Homo sapiens	22-25
29408707-9	2018	Moreover, Poly-I:C treatment induced a marked antiviral response including increases of interferons IFNB, IL-28B and a group of interferon-stimulated genes.	Poly I-C	10-18	interferon beta 1	Homo sapiens	100-104
29408707-9	2018	Moreover, Poly-I:C treatment induced a marked antiviral response including increases of interferons IFNB, IL-28B and a group of interferon-stimulated genes.	Poly I-C	10-18	interferon lambda 3	Homo sapiens	106-112
29397427-5	2018	Therefore, in the current study, poly(I:C), as a potent Th1 inducer adjuvant, was evaluated to improve the immunogenicity of recombinant PfMSP-142, when compared to CFA/IFA, as reference adjuvant.	Poly I-C	33-41	negative elongation factor complex member C/D	Homo sapiens	56-59
29518010-6	2018	Inhibition of NF-kappaB, p38, STAT-1 and STAT-3 signaling resulted in decreased cytokine expression, whereas inhibition of mitogen-activated protein kinase kinase 1/2 (MEK1/2) signaling showed a negative feedback role in both poly(I:C)- and poly(dA:dT)-induced cytokine expression.	Poly I-C	226-234	mitogen-activated protein kinase kinase 1	Homo sapiens	123-166
29599452-9	2018	Whereas, poly(I:C)-(HMW) and Pam3CSK4 mainly induced the expression of classical genes from the interferon or NF-kappaB pathway respectively, Riboxxol had a mixed phenotype.	Poly I-C	9-18	cilia and flagella associated protein 97	Homo sapiens	20-23
29587772-4	2018	METHODS: The involvement of oxidative stress in the expression of IL-33, and its signal pathway was examined after stimulation with hydrogen peroxide (H2O2), with or without stimulation by polyinosinic-polycytidylic acid [poly (I:C)], a synthetic analogue of dsRNA that mimics viral infection, or rhinovirus infection in NCI-H292 cells and primary human bronchial epithelial cells (HBECs).	Poly I-C	189-220	interleukin 33	Homo sapiens	66-71
29325713-14	2018	Moreover, the roles of LcTAK1 and LcTAB1 in immune response analysis showed that NF-kappaB activation enhanced significantly in co-overexpressed HEK293T cells following LPS and poly I:C stimulation.	Poly I-C	177-185	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	Larimichthys crocea	34-40
29541027-9	2018	Macrophage chemotaxis was induced by the supernatant of poly(I:C)-treated IEC which was consistent with the level of CXCL10 secreted.	Poly I-C	56-65	chemokine (C-X-C motif) ligand 10	Mus musculus	117-123
30052978-6	2018	There was a strong trend (P=.05) to lower cortical PTGS1 10 months after mice were treated postnatally with polyinosinic-polycytidylic acid sodium salt (Poly I:C), consistent with cortical PTGS1 being lower in adult mice after exposure to an immune activator postnatally.	Poly I-C	153-161	prostaglandin-endoperoxide synthase 1	Mus musculus	51-56
29415896-6	2018	In parallel with this loss, the expression of progenitor-like genes such as SOX9 was activated following PolyI:C treatment or enteroviral infection.	Poly I-C	105-112	SRY-box transcription factor 9	Homo sapiens	76-80
28914974-8	2018	RESULTS: We found that human epidermis and conjunctival epithelium expressed IKZF1, and in PHCjECs and HEKa, the expression of IKZF1 mRNA was upregulated by stimulation with polyI:C, a TLR3 ligand.	Poly I-C	174-181	IKAROS family zinc finger 1	Homo sapiens	77-82
29721392-1	2018	The Toll-like receptor 3 (TLR3) agonists as polyriboinosinic-polyribocytidylic acid (poly (I:C)) have been implicated as potential immunotherapy adjuvant for cancer whereas the exact roles of TLR3 agonists in hepatocellular carcinoma (HCC) treatment have not been clearly evaluated.	Poly I-C	44-83	toll like receptor 3	Homo sapiens	4-24
29721392-1	2018	The Toll-like receptor 3 (TLR3) agonists as polyriboinosinic-polyribocytidylic acid (poly (I:C)) have been implicated as potential immunotherapy adjuvant for cancer whereas the exact roles of TLR3 agonists in hepatocellular carcinoma (HCC) treatment have not been clearly evaluated.	Poly I-C	44-83	toll like receptor 3	Homo sapiens	26-30
29402958-4	2018	Poly(I:C) activates both IRF3 and NF-kappaB, a requirement for induction of IFNbeta expression.	Poly I-C	0-8	interferon regulatory factor 3	Homo sapiens	25-29
29402958-4	2018	Poly(I:C) activates both IRF3 and NF-kappaB, a requirement for induction of IFNbeta expression.	Poly I-C	0-8	nuclear factor kappa B subunit 1	Homo sapiens	34-43
29402958-4	2018	Poly(I:C) activates both IRF3 and NF-kappaB, a requirement for induction of IFNbeta expression.	Poly I-C	0-8	interferon beta 1	Homo sapiens	76-83
28914974-8	2018	RESULTS: We found that human epidermis and conjunctival epithelium expressed IKZF1, and in PHCjECs and HEKa, the expression of IKZF1 mRNA was upregulated by stimulation with polyI:C, a TLR3 ligand.	Poly I-C	174-181	IKAROS family zinc finger 1	Homo sapiens	127-132
28914974-8	2018	RESULTS: We found that human epidermis and conjunctival epithelium expressed IKZF1, and in PHCjECs and HEKa, the expression of IKZF1 mRNA was upregulated by stimulation with polyI:C, a TLR3 ligand.	Poly I-C	174-181	toll like receptor 3	Homo sapiens	185-189
29245047-0	2018	Polyriboinosinic-polyribocytidylic acid facilitates interleukin-6, and interleukin-8 secretion in human dermal fibroblasts via the JAK/STAT3 and p38 MAPK signal transduction pathways.	Poly I-C	0-39	interleukin 6	Homo sapiens	52-65
29245047-0	2018	Polyriboinosinic-polyribocytidylic acid facilitates interleukin-6, and interleukin-8 secretion in human dermal fibroblasts via the JAK/STAT3 and p38 MAPK signal transduction pathways.	Poly I-C	0-39	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
29245047-7	2018	In conclusion, polyI:C induces IL-6 and IL-8 production in HDFs via the JAK/STAT3 and p38 MAPK signaling pathways.	Poly I-C	15-22	interleukin 6	Homo sapiens	31-35
29245047-7	2018	In conclusion, polyI:C induces IL-6 and IL-8 production in HDFs via the JAK/STAT3 and p38 MAPK signaling pathways.	Poly I-C	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
29245047-7	2018	In conclusion, polyI:C induces IL-6 and IL-8 production in HDFs via the JAK/STAT3 and p38 MAPK signaling pathways.	Poly I-C	15-22	signal transducer and activator of transcription 3	Homo sapiens	76-81
29245047-7	2018	In conclusion, polyI:C induces IL-6 and IL-8 production in HDFs via the JAK/STAT3 and p38 MAPK signaling pathways.	Poly I-C	15-22	mitogen-activated protein kinase 14	Homo sapiens	86-89
29245047-0	2018	Polyriboinosinic-polyribocytidylic acid facilitates interleukin-6, and interleukin-8 secretion in human dermal fibroblasts via the JAK/STAT3 and p38 MAPK signal transduction pathways.	Poly I-C	0-39	signal transducer and activator of transcription 3	Homo sapiens	135-140
29245047-0	2018	Polyriboinosinic-polyribocytidylic acid facilitates interleukin-6, and interleukin-8 secretion in human dermal fibroblasts via the JAK/STAT3 and p38 MAPK signal transduction pathways.	Poly I-C	0-39	mitogen-activated protein kinase 14	Homo sapiens	145-148
29245047-3	2018	Here, we found that polyI:C enhances IL-6 and IL-8 mRNA expression and induces of IL-6 and IL-8 production in a concentration-dependent and time-dependent manner in HDFs.	Poly I-C	20-27	interleukin 6	Homo sapiens	37-41
29245047-3	2018	Here, we found that polyI:C enhances IL-6 and IL-8 mRNA expression and induces of IL-6 and IL-8 production in a concentration-dependent and time-dependent manner in HDFs.	Poly I-C	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
29245047-3	2018	Here, we found that polyI:C enhances IL-6 and IL-8 mRNA expression and induces of IL-6 and IL-8 production in a concentration-dependent and time-dependent manner in HDFs.	Poly I-C	20-27	interleukin 6	Homo sapiens	82-86
29245047-3	2018	Here, we found that polyI:C enhances IL-6 and IL-8 mRNA expression and induces of IL-6 and IL-8 production in a concentration-dependent and time-dependent manner in HDFs.	Poly I-C	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
29245047-4	2018	PolyI:C treatment rapidly increased phosphorylation level of both STAT3 and p38 mitogen-activated protein kinase (MAPK).	Poly I-C	0-7	signal transducer and activator of transcription 3	Homo sapiens	66-71
29245047-4	2018	PolyI:C treatment rapidly increased phosphorylation level of both STAT3 and p38 mitogen-activated protein kinase (MAPK).	Poly I-C	0-7	mitogen-activated protein kinase 14	Homo sapiens	76-112
29245047-5	2018	Moreover, pretreatment with AG490, a Janus kinase (JAK) inhibitor, inhibited polyI:C-induced STAT3 phosphorylation and subsequent IL-6 and IL-8 release.	Poly I-C	77-84	signal transducer and activator of transcription 3	Homo sapiens	93-98
29245047-5	2018	Moreover, pretreatment with AG490, a Janus kinase (JAK) inhibitor, inhibited polyI:C-induced STAT3 phosphorylation and subsequent IL-6 and IL-8 release.	Poly I-C	77-84	interleukin 6	Homo sapiens	130-134
29245047-5	2018	Moreover, pretreatment with AG490, a Janus kinase (JAK) inhibitor, inhibited polyI:C-induced STAT3 phosphorylation and subsequent IL-6 and IL-8 release.	Poly I-C	77-84	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
29324236-6	2018	We also found that siRNA-mediated knockdown of IRF1 expression resulted in lower ISG15 expression in response to polyinosinic:polycytidylic acid [poly(I:C)] or CSFV infection.	Poly I-C	113-144	interferon regulatory factor 1	Sus scrofa	47-51
29277364-7	2018	Here we report the clear induction of sb-isg15 transcript levels in SAF-1 cells and AGs stimulated with toll-like receptor (TLR) ligands, such as polyinosinic:polycytidylic acid (poly I:C) or genomic DNA from Vibrio anguillarum (VaDNA), respectively.	Poly I-C	179-187	ISG15 ubiquitin like modifier	Homo sapiens	41-46
29331803-6	2018	Submandibular glands (SMGs) of the C57BL/6 mice were challenged with the TLR3 stimulant: polyinosinic-polycytidylic acid (poly (I:C)).	Poly I-C	89-120	toll-like receptor 3	Mus musculus	73-77
29324236-6	2018	We also found that siRNA-mediated knockdown of IRF1 expression resulted in lower ISG15 expression in response to polyinosinic:polycytidylic acid [poly(I:C)] or CSFV infection.	Poly I-C	113-144	ISG15 ubiquitin like modifier	Homo sapiens	81-86
29214775-10	2018	Furthermore, poly (I:C), a TLR3 agonist, markedly abolished TRIM56 depletion-induced increase of proliferation, decrease of apoptosis, and reduction of inflammatory factor in MM cells.	Poly I-C	13-22	toll like receptor 3	Homo sapiens	27-31
29434584-5	2018	We show that EV released from unstimulated cells and Poly(I:C)-stimulated U937 cells [Poly(I:C) EV] differ in size but bind similar amounts of Annexin V and express comparable levels of MAC-1, the receptor for dsRNA, on the vesicular membranes.	Poly I-C	53-62	annexin A5	Homo sapiens	143-152
29434584-5	2018	We show that EV released from unstimulated cells and Poly(I:C)-stimulated U937 cells [Poly(I:C) EV] differ in size but bind similar amounts of Annexin V and express comparable levels of MAC-1, the receptor for dsRNA, on the vesicular membranes.	Poly I-C	53-62	integrin subunit alpha M	Homo sapiens	186-191
29434584-6	2018	Specifically, Poly(I:C) EV contain or associate with Poly(I:C) and at least partially protect Poly(I:C) from RNAse III degradation.	Poly I-C	14-22	drosha ribonuclease III	Homo sapiens	109-118
29301276-5	2018	Neurons and astrocytes released interleukin-10 (IL-10) and prostaglandin E2 (PGE2) in response to LPS and PIC.	Poly I-C	106-109	interleukin 10	Rattus norvegicus	32-46
29301276-5	2018	Neurons and astrocytes released interleukin-10 (IL-10) and prostaglandin E2 (PGE2) in response to LPS and PIC.	Poly I-C	106-109	interleukin 10	Rattus norvegicus	48-53
29141862-6	2018	Furthermore, Poly(I:C) and LPS induced endothelial to mesenchymal transition that was reversed by the pretreatment with TGF-beta neutralizing Ab or re-expression of Fli1.	Poly I-C	13-21	transforming growth factor beta 1	Homo sapiens	120-128
29141862-6	2018	Furthermore, Poly(I:C) and LPS induced endothelial to mesenchymal transition that was reversed by the pretreatment with TGF-beta neutralizing Ab or re-expression of Fli1.	Poly I-C	13-21	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	165-169
29207132-14	2018	In conclusion, IRF3 signaling pathway serves an important role in poly(I:C)-induced procollagen reduction in skin fibroblasts.	Poly I-C	66-75	interferon regulatory factor 3	Homo sapiens	15-19
29294448-5	2018	Overexpression of 8b and 8ab resulted in the reduction of poly (I:C)-induced IRF3 dimerization and inhibition of the IFN-beta signaling pathway.	Poly I-C	58-68	interferon regulatory factor 3	Homo sapiens	77-81
29294448-5	2018	Overexpression of 8b and 8ab resulted in the reduction of poly (I:C)-induced IRF3 dimerization and inhibition of the IFN-beta signaling pathway.	Poly I-C	58-68	interferon beta 1	Homo sapiens	117-125
29435413-5	2018	Furthermore, the expression of MuRF2 was down-regulated in RAW264.7 cells activated with LPS but not in cells treated with polyinosinic-polycytidylic acid (Poly(I:C)) or with lipidosome plus Poly(I:C).	Poly I-C	123-154	tripartite motif-containing 55	Mus musculus	31-36
28872665-7	2018	The Toll-like receptor (TLR)-3 ligand, polyinosinic-polycytidylic acid (poly(I:C), induced LL-37 mRNA expression and stimulated LL-37 secretion in colonic SEMFs.	Poly I-C	39-70	toll like receptor 4	Homo sapiens	4-8
28872665-7	2018	The Toll-like receptor (TLR)-3 ligand, polyinosinic-polycytidylic acid (poly(I:C), induced LL-37 mRNA expression and stimulated LL-37 secretion in colonic SEMFs.	Poly I-C	39-70	toll like receptor 3	Homo sapiens	24-27
28872665-7	2018	The Toll-like receptor (TLR)-3 ligand, polyinosinic-polycytidylic acid (poly(I:C), induced LL-37 mRNA expression and stimulated LL-37 secretion in colonic SEMFs.	Poly I-C	39-70	cathelicidin antimicrobial peptide	Homo sapiens	91-96
28872665-7	2018	The Toll-like receptor (TLR)-3 ligand, polyinosinic-polycytidylic acid (poly(I:C), induced LL-37 mRNA expression and stimulated LL-37 secretion in colonic SEMFs.	Poly I-C	39-70	cathelicidin antimicrobial peptide	Homo sapiens	128-133
28872665-9	2018	Poly(I:C)-induced phosphorylation of mitogen-activated protein kinases (MAPKs) and activated nuclear factor kappa B (NF-kappaB) and activating factor protein (AP)-1.	Poly I-C	0-8	nuclear factor kappa B subunit 1	Homo sapiens	93-115
28872665-9	2018	Poly(I:C)-induced phosphorylation of mitogen-activated protein kinases (MAPKs) and activated nuclear factor kappa B (NF-kappaB) and activating factor protein (AP)-1.	Poly I-C	0-8	nuclear factor kappa B subunit 1	Homo sapiens	117-164
28923593-3	2018	In miiuy croaker, miR-122 is sensitive to poly(I:C) stimulation.	Poly I-C	42-51	microRNA 122	Mus musculus	18-25
29214775-10	2018	Furthermore, poly (I:C), a TLR3 agonist, markedly abolished TRIM56 depletion-induced increase of proliferation, decrease of apoptosis, and reduction of inflammatory factor in MM cells.	Poly I-C	13-22	tripartite motif containing 56	Homo sapiens	60-66
29237464-8	2017	Mechanistic analyses suggest the secretion of Wnt ligands by AEC along with a degradation of the cellular junctions after poly(I:C) exposure, leading to the release of beta-catenin from the cell membrane and stimulation of the Wnt/beta-catenin pathway.	Poly I-C	122-131	catenin beta 1	Homo sapiens	168-180
29237464-8	2017	Mechanistic analyses suggest the secretion of Wnt ligands by AEC along with a degradation of the cellular junctions after poly(I:C) exposure, leading to the release of beta-catenin from the cell membrane and stimulation of the Wnt/beta-catenin pathway.	Poly I-C	122-131	catenin beta 1	Homo sapiens	231-243
29039048-5	2017	Treatment with poly(I:C) induces the expression of the apoptosis-inducer TNF-related apoptosis-inducing ligand (TRAIL), along with the antiviral molecule IFN-beta1, and reduces the viability of BECs by enhancing apoptosis.	Poly I-C	15-23	TNF superfamily member 10	Homo sapiens	73-110
29399410-7	2018	Cocultures of poly(I:C)-treated glioblastoma cells with peripheral blood mononuclear cells enhanced lymphocytic activation (CD69, IFN-gamma) and cytotoxic capacity (CD107a, granzyme B).	Poly I-C	14-23	CD69 molecule	Homo sapiens	124-128
29399410-7	2018	Cocultures of poly(I:C)-treated glioblastoma cells with peripheral blood mononuclear cells enhanced lymphocytic activation (CD69, IFN-gamma) and cytotoxic capacity (CD107a, granzyme B).	Poly I-C	14-23	interferon gamma	Homo sapiens	130-139
29399410-7	2018	Cocultures of poly(I:C)-treated glioblastoma cells with peripheral blood mononuclear cells enhanced lymphocytic activation (CD69, IFN-gamma) and cytotoxic capacity (CD107a, granzyme B).	Poly I-C	14-23	lysosomal associated membrane protein 1	Homo sapiens	165-171
29399410-7	2018	Cocultures of poly(I:C)-treated glioblastoma cells with peripheral blood mononuclear cells enhanced lymphocytic activation (CD69, IFN-gamma) and cytotoxic capacity (CD107a, granzyme B).	Poly I-C	14-23	granzyme B	Homo sapiens	173-183
29399410-9	2018	Besides activating immunity, poly(I:C)-treated glioblastoma cells also doubled the attraction of CD8+ T cells, and to a lesser extent CD4+ T cells, via a mechanism which included CXCR3 and CCR5 ligands.	Poly I-C	29-38	C-X-C motif chemokine receptor 3	Homo sapiens	179-184
29399410-9	2018	Besides activating immunity, poly(I:C)-treated glioblastoma cells also doubled the attraction of CD8+ T cells, and to a lesser extent CD4+ T cells, via a mechanism which included CXCR3 and CCR5 ligands.	Poly I-C	29-38	C-C motif chemokine receptor 5	Homo sapiens	189-193
29032197-6	2017	Stimulation with poly I:C upregulated PD-L1 expression on BEAS-2B cells.	Poly I-C	17-25	CD274 molecule	Homo sapiens	38-43
29032197-9	2017	Treatment of cells with STAT3 siRNA abolished the effect of IL-22 on the poly I:C-induced upregulation of PD-L1.	Poly I-C	73-81	signal transducer and activator of transcription 3	Homo sapiens	24-29
29032197-9	2017	Treatment of cells with STAT3 siRNA abolished the effect of IL-22 on the poly I:C-induced upregulation of PD-L1.	Poly I-C	73-81	interleukin 22	Homo sapiens	60-65
29032197-9	2017	Treatment of cells with STAT3 siRNA abolished the effect of IL-22 on the poly I:C-induced upregulation of PD-L1.	Poly I-C	73-81	CD274 molecule	Homo sapiens	106-111
28912382-4	2017	We show that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I interferons, and IFNAR1, leading to increased expression of versican by macrophages and implicating versican as an interferon-stimulated gene.	Poly I-C	21-52	toll-like receptor 3	Mus musculus	103-107
28912382-4	2017	We show that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I interferons, and IFNAR1, leading to increased expression of versican by macrophages and implicating versican as an interferon-stimulated gene.	Poly I-C	21-52	toll-like receptor 4	Mus musculus	111-115
28912382-4	2017	We show that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I interferons, and IFNAR1, leading to increased expression of versican by macrophages and implicating versican as an interferon-stimulated gene.	Poly I-C	21-52	toll-like receptor adaptor molecule 1	Mus musculus	121-125
28912382-4	2017	We show that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I interferons, and IFNAR1, leading to increased expression of versican by macrophages and implicating versican as an interferon-stimulated gene.	Poly I-C	21-52	interferon (alpha and beta) receptor 1	Mus musculus	159-165
28912382-4	2017	We show that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I interferons, and IFNAR1, leading to increased expression of versican by macrophages and implicating versican as an interferon-stimulated gene.	Poly I-C	21-52	versican	Mus musculus	202-210
28912382-4	2017	We show that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I interferons, and IFNAR1, leading to increased expression of versican by macrophages and implicating versican as an interferon-stimulated gene.	Poly I-C	21-52	versican	Mus musculus	242-250
28912382-4	2017	We show that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I interferons, and IFNAR1, leading to increased expression of versican by macrophages and implicating versican as an interferon-stimulated gene.	Poly I-C	54-63	toll-like receptor 3	Mus musculus	103-107
28912382-4	2017	We show that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I interferons, and IFNAR1, leading to increased expression of versican by macrophages and implicating versican as an interferon-stimulated gene.	Poly I-C	54-63	toll-like receptor 4	Mus musculus	111-115
28912382-4	2017	We show that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I interferons, and IFNAR1, leading to increased expression of versican by macrophages and implicating versican as an interferon-stimulated gene.	Poly I-C	54-63	toll-like receptor adaptor molecule 1	Mus musculus	121-125
28912382-4	2017	We show that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I interferons, and IFNAR1, leading to increased expression of versican by macrophages and implicating versican as an interferon-stimulated gene.	Poly I-C	54-63	interferon (alpha and beta) receptor 1	Mus musculus	159-165
28912382-4	2017	We show that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I interferons, and IFNAR1, leading to increased expression of versican by macrophages and implicating versican as an interferon-stimulated gene.	Poly I-C	54-63	versican	Mus musculus	202-210
28912382-4	2017	We show that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I interferons, and IFNAR1, leading to increased expression of versican by macrophages and implicating versican as an interferon-stimulated gene.	Poly I-C	54-63	versican	Mus musculus	242-250
28912382-10	2017	These studies show increased recovery of inflammatory cells in the bronchoalveolar lavage fluid of poly(I:C)-treated LysM/Vcan-/- mice compared with control mice.	Poly I-C	99-108	lysozyme 2	Mus musculus	117-121
28912382-10	2017	These studies show increased recovery of inflammatory cells in the bronchoalveolar lavage fluid of poly(I:C)-treated LysM/Vcan-/- mice compared with control mice.	Poly I-C	99-108	versican	Mus musculus	122-126
28912382-11	2017	IFN-beta and IL-10, two important anti-inflammatory molecules, are significantly decreased in both poly(I:C)-treated BMDMs from LysM/Vcan-/- mice and bronchoalveolar lavage fluid from poly(I:C)-treated LysM/Vcan-/- mice compared with control mice.	Poly I-C	99-108	interferon beta 1, fibroblast	Mus musculus	0-8
28912382-11	2017	IFN-beta and IL-10, two important anti-inflammatory molecules, are significantly decreased in both poly(I:C)-treated BMDMs from LysM/Vcan-/- mice and bronchoalveolar lavage fluid from poly(I:C)-treated LysM/Vcan-/- mice compared with control mice.	Poly I-C	99-108	interleukin 10	Mus musculus	13-18
28912382-11	2017	IFN-beta and IL-10, two important anti-inflammatory molecules, are significantly decreased in both poly(I:C)-treated BMDMs from LysM/Vcan-/- mice and bronchoalveolar lavage fluid from poly(I:C)-treated LysM/Vcan-/- mice compared with control mice.	Poly I-C	99-108	lysozyme 2	Mus musculus	128-132
28912382-11	2017	IFN-beta and IL-10, two important anti-inflammatory molecules, are significantly decreased in both poly(I:C)-treated BMDMs from LysM/Vcan-/- mice and bronchoalveolar lavage fluid from poly(I:C)-treated LysM/Vcan-/- mice compared with control mice.	Poly I-C	99-108	versican	Mus musculus	133-137
28912382-11	2017	IFN-beta and IL-10, two important anti-inflammatory molecules, are significantly decreased in both poly(I:C)-treated BMDMs from LysM/Vcan-/- mice and bronchoalveolar lavage fluid from poly(I:C)-treated LysM/Vcan-/- mice compared with control mice.	Poly I-C	99-108	lysozyme 2	Mus musculus	202-206
28912382-11	2017	IFN-beta and IL-10, two important anti-inflammatory molecules, are significantly decreased in both poly(I:C)-treated BMDMs from LysM/Vcan-/- mice and bronchoalveolar lavage fluid from poly(I:C)-treated LysM/Vcan-/- mice compared with control mice.	Poly I-C	99-108	versican	Mus musculus	207-211
28912382-11	2017	IFN-beta and IL-10, two important anti-inflammatory molecules, are significantly decreased in both poly(I:C)-treated BMDMs from LysM/Vcan-/- mice and bronchoalveolar lavage fluid from poly(I:C)-treated LysM/Vcan-/- mice compared with control mice.	Poly I-C	184-193	interferon beta 1, fibroblast	Mus musculus	0-8
28912382-11	2017	IFN-beta and IL-10, two important anti-inflammatory molecules, are significantly decreased in both poly(I:C)-treated BMDMs from LysM/Vcan-/- mice and bronchoalveolar lavage fluid from poly(I:C)-treated LysM/Vcan-/- mice compared with control mice.	Poly I-C	184-193	interleukin 10	Mus musculus	13-18
29039048-5	2017	Treatment with poly(I:C) induces the expression of the apoptosis-inducer TNF-related apoptosis-inducing ligand (TRAIL), along with the antiviral molecule IFN-beta1, and reduces the viability of BECs by enhancing apoptosis.	Poly I-C	15-23	TNF superfamily member 10	Homo sapiens	112-117
28842514-7	2017	Poly(I:C) stimulation resulted in 212 DEGs (&gt;1.5 fold-change, FDR &lt;0.05) in ASMCs from chronic cough patients compared with 1674 DEGs in healthy non-cough volunteers.	Poly I-C	0-8	delta 4-desaturase, sphingolipid 1	Homo sapiens	38-42
28943194-5	2017	OVA/poly(I:C)-loaded nanoparticles and OVA/poly(I:C) solution elicited similarly strong total IgG and IgG1 responses.	Poly I-C	4-12	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	0-3
28943194-5	2017	OVA/poly(I:C)-loaded nanoparticles and OVA/poly(I:C) solution elicited similarly strong total IgG and IgG1 responses.	Poly I-C	4-12	LOC105243590	Mus musculus	102-106
28943194-6	2017	However, the co-encapsulation of OVA and poly(I:C) in nanoparticles significantly increased the IgG2a response compared to OVA/poly(I:C) solution.	Poly I-C	41-49	immunoglobulin heavy variable V1-9	Mus musculus	96-101
28943194-6	2017	However, the co-encapsulation of OVA and poly(I:C) in nanoparticles significantly increased the IgG2a response compared to OVA/poly(I:C) solution.	Poly I-C	127-135	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	33-36
28958936-6	2017	M8I inhibited the LPS- or poly(I:C)-induced production of the tumor necrosis factor-alpha and nitric oxide, alone or in combination with CSF-1 or IL-34.	Poly I-C	26-35	tumor necrosis factor	Mus musculus	62-89
28958936-6	2017	M8I inhibited the LPS- or poly(I:C)-induced production of the tumor necrosis factor-alpha and nitric oxide, alone or in combination with CSF-1 or IL-34.	Poly I-C	26-35	interleukin 34	Mus musculus	146-151
28842514-7	2017	Poly(I:C) stimulation resulted in 212 DEGs (&gt;1.5 fold-change, FDR &lt;0.05) in ASMCs from chronic cough patients compared with 1674 DEGs in healthy non-cough volunteers.	Poly I-C	0-8	delta 4-desaturase, sphingolipid 1	Homo sapiens	135-139
29141219-3	2017	Injection of pIC at the pre-cancer stage robustly suppressed liver tumorigenesis either induced by chemical carcinogens or by Pten loss and associated hepatosteatosis.	Poly I-C	13-16	phosphatase and tensin homolog	Mus musculus	126-130
28913994-0	2017	Mouse Model of IL-17-Dominant Rhinitis Using Polyinosinic-Polycytidylic Acid.	Poly I-C	45-76	interleukin 17A	Mus musculus	15-20
28913994-3	2017	Our objective was to establish a mouse model of IL-17-dominant rhinitis via intranasal application of polyinosinic-polycytidylic acid (abbreviated as Poly(I:C)).	Poly I-C	102-133	interleukin 17A	Mus musculus	48-53
28778400-10	2017	LPS or poly(I:C) induced p65 translocation and phosphorylation of IkappaBalpha, p65, p38, and JNK were suppressed by GC31.GC31 is not only an effective inhibitor of LPS-induced inflammatory response, but it also inhibits poly(I:C)-induced release of inflammatory cytokines and ICAM-1 expression by blocking the NF-kappaB and MAPK (p38 and JNK) pathways.	Poly I-C	7-15	RELA proto-oncogene, NF-kB subunit	Homo sapiens	25-28
28970238-2	2017	We detected specific abrogation of macrophage responses to polyinosinic-polycytidylic acid (poly(I:C)) resulting from three independent N-ethyl-N-nitrosourea-induced mutations in host cell factor C2 (Hcfc2).	Poly I-C	59-90	host cell factor C2	Homo sapiens	179-198
28970238-2	2017	We detected specific abrogation of macrophage responses to polyinosinic-polycytidylic acid (poly(I:C)) resulting from three independent N-ethyl-N-nitrosourea-induced mutations in host cell factor C2 (Hcfc2).	Poly I-C	59-90	host cell factor C2	Homo sapiens	200-205
29081092-6	2017	Further mechanistic studies showed that galangin inhibited poly(I:C)-induced nuclear factor (NF)-kappaB activity and phosphorylation of Akt without affecting MAP kinases.	Poly I-C	59-68	thymoma viral proto-oncogene 1	Mus musculus	136-139
28778400-10	2017	LPS or poly(I:C) induced p65 translocation and phosphorylation of IkappaBalpha, p65, p38, and JNK were suppressed by GC31.GC31 is not only an effective inhibitor of LPS-induced inflammatory response, but it also inhibits poly(I:C)-induced release of inflammatory cytokines and ICAM-1 expression by blocking the NF-kappaB and MAPK (p38 and JNK) pathways.	Poly I-C	7-15	NFKB inhibitor alpha	Homo sapiens	66-78
28778400-10	2017	LPS or poly(I:C) induced p65 translocation and phosphorylation of IkappaBalpha, p65, p38, and JNK were suppressed by GC31.GC31 is not only an effective inhibitor of LPS-induced inflammatory response, but it also inhibits poly(I:C)-induced release of inflammatory cytokines and ICAM-1 expression by blocking the NF-kappaB and MAPK (p38 and JNK) pathways.	Poly I-C	7-15	RELA proto-oncogene, NF-kB subunit	Homo sapiens	80-83
28778400-10	2017	LPS or poly(I:C) induced p65 translocation and phosphorylation of IkappaBalpha, p65, p38, and JNK were suppressed by GC31.GC31 is not only an effective inhibitor of LPS-induced inflammatory response, but it also inhibits poly(I:C)-induced release of inflammatory cytokines and ICAM-1 expression by blocking the NF-kappaB and MAPK (p38 and JNK) pathways.	Poly I-C	7-15	mitogen-activated protein kinase 14	Homo sapiens	85-88
28778400-10	2017	LPS or poly(I:C) induced p65 translocation and phosphorylation of IkappaBalpha, p65, p38, and JNK were suppressed by GC31.GC31 is not only an effective inhibitor of LPS-induced inflammatory response, but it also inhibits poly(I:C)-induced release of inflammatory cytokines and ICAM-1 expression by blocking the NF-kappaB and MAPK (p38 and JNK) pathways.	Poly I-C	7-15	mitogen-activated protein kinase 8	Homo sapiens	94-97
28778400-10	2017	LPS or poly(I:C) induced p65 translocation and phosphorylation of IkappaBalpha, p65, p38, and JNK were suppressed by GC31.GC31 is not only an effective inhibitor of LPS-induced inflammatory response, but it also inhibits poly(I:C)-induced release of inflammatory cytokines and ICAM-1 expression by blocking the NF-kappaB and MAPK (p38 and JNK) pathways.	Poly I-C	7-15	intercellular adhesion molecule 1	Homo sapiens	277-283
28778400-10	2017	LPS or poly(I:C) induced p65 translocation and phosphorylation of IkappaBalpha, p65, p38, and JNK were suppressed by GC31.GC31 is not only an effective inhibitor of LPS-induced inflammatory response, but it also inhibits poly(I:C)-induced release of inflammatory cytokines and ICAM-1 expression by blocking the NF-kappaB and MAPK (p38 and JNK) pathways.	Poly I-C	7-15	mitogen-activated protein kinase 14	Homo sapiens	331-334
28778400-10	2017	LPS or poly(I:C) induced p65 translocation and phosphorylation of IkappaBalpha, p65, p38, and JNK were suppressed by GC31.GC31 is not only an effective inhibitor of LPS-induced inflammatory response, but it also inhibits poly(I:C)-induced release of inflammatory cytokines and ICAM-1 expression by blocking the NF-kappaB and MAPK (p38 and JNK) pathways.	Poly I-C	7-15	mitogen-activated protein kinase 8	Homo sapiens	339-342
29088306-6	2017	We further investigated whether polyinosinic-polycytidylic acid (poly I:C)-induced NK cell activation could ameliorate TRAIL expression in the liver after 70% hepatectomy in CXCR3-/- and wild-type mice.	Poly I-C	32-63	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	119-124
28150518-6	2017	Knockdown of p65 inhibited the poly IC-induced IFN-beta expression, and chloroquine pretreatment decreased the nuclear poly IC-induced translocation of NF-kappaB p65 in MCs.	Poly I-C	31-38	RELA proto-oncogene, NF-kB subunit	Homo sapiens	13-16
28150518-6	2017	Knockdown of p65 inhibited the poly IC-induced IFN-beta expression, and chloroquine pretreatment decreased the nuclear poly IC-induced translocation of NF-kappaB p65 in MCs.	Poly I-C	31-38	interferon beta 1	Homo sapiens	47-55
28870522-3	2017	Using organ-cultured arteries, we found that poly (I:C) (30mug/mL for approximately 1 day) markedly reduced sodium nitroprusside (SNP)-induced relaxation (vs. vehicle); this was prevented by co-treatment with a TLR3 inhibitor.	Poly I-C	45-55	toll-like receptor 3	Rattus norvegicus	211-215
28849057-0	2017	Stable silencing of TIPE2 reduced the Poly I:C-induced apoptosis in THP-1 cells.	Poly I-C	38-46	TNF alpha induced protein 8 like 2	Homo sapiens	20-25
28849057-1	2017	The present study aimed to determine the underlying mechanism of toll-like receptor (TLR) agonist polyinosinic:polycytidylic acid (Poly I:C)-induced apoptosis in THP-1 cells following silencing the expression of tumor necrosis factor alpha-induced protein 8-like 2 (TIPE2).	Poly I-C	131-139	TNF alpha induced protein 8 like 2	Homo sapiens	212-264
28849057-1	2017	The present study aimed to determine the underlying mechanism of toll-like receptor (TLR) agonist polyinosinic:polycytidylic acid (Poly I:C)-induced apoptosis in THP-1 cells following silencing the expression of tumor necrosis factor alpha-induced protein 8-like 2 (TIPE2).	Poly I-C	131-139	TNF alpha induced protein 8 like 2	Homo sapiens	266-271
28849057-6	2017	The TLRs agonist Poly I:C increased the expression level of TIPE2.	Poly I-C	17-25	TNF alpha induced protein 8 like 2	Homo sapiens	60-65
28849057-8	2017	Following silencing of TIPE2 in THP-1 cells, the Poly I:C-induced TIPE2 expression was significantly downregulated.	Poly I-C	49-57	TNF alpha induced protein 8 like 2	Homo sapiens	23-28
28849057-8	2017	Following silencing of TIPE2 in THP-1 cells, the Poly I:C-induced TIPE2 expression was significantly downregulated.	Poly I-C	49-57	TNF alpha induced protein 8 like 2	Homo sapiens	66-71
28849057-9	2017	Additionally, the Poly I:C-induced proliferation inhibition and apoptosis in THP-1 cells were significantly reduced following silencing of TIPE2.	Poly I-C	18-26	TNF alpha induced protein 8 like 2	Homo sapiens	139-144
28849057-11	2017	In conclusion, the expression of TIPE2 in THP-1 cells may be upregulated by Poly I:C, which may also inhibit cell proliferation and induce apoptosis.	Poly I-C	76-84	TNF alpha induced protein 8 like 2	Homo sapiens	33-38
28849057-12	2017	Following the downregulation of TIPE2 the aforementioned effect of Poly I:C treatment was reversed and may be associated with the reduced activity of caspase-8 that was observed in the TIPE2 silenced group.	Poly I-C	67-75	TNF alpha induced protein 8 like 2	Homo sapiens	32-37
28849057-12	2017	Following the downregulation of TIPE2 the aforementioned effect of Poly I:C treatment was reversed and may be associated with the reduced activity of caspase-8 that was observed in the TIPE2 silenced group.	Poly I-C	67-75	caspase 8	Homo sapiens	150-159
28849057-12	2017	Following the downregulation of TIPE2 the aforementioned effect of Poly I:C treatment was reversed and may be associated with the reduced activity of caspase-8 that was observed in the TIPE2 silenced group.	Poly I-C	67-75	TNF alpha induced protein 8 like 2	Homo sapiens	185-190
29088306-6	2017	We further investigated whether polyinosinic-polycytidylic acid (poly I:C)-induced NK cell activation could ameliorate TRAIL expression in the liver after 70% hepatectomy in CXCR3-/- and wild-type mice.	Poly I-C	65-73	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	119-124
29088306-10	2017	Although the administration of poly I:C, an inducer of interferon-gamma, increased hepatic CXCL9 levels in both CXCR3-/- and wild-type mice even after hepatectomy, only wild-type mice exhibited the recovery of TRAIL expression on NK cells.	Poly I-C	31-39	interferon gamma	Mus musculus	55-71
29088306-10	2017	Although the administration of poly I:C, an inducer of interferon-gamma, increased hepatic CXCL9 levels in both CXCR3-/- and wild-type mice even after hepatectomy, only wild-type mice exhibited the recovery of TRAIL expression on NK cells.	Poly I-C	31-39	chemokine (C-X-C motif) ligand 9	Mus musculus	91-96
29088306-10	2017	Although the administration of poly I:C, an inducer of interferon-gamma, increased hepatic CXCL9 levels in both CXCR3-/- and wild-type mice even after hepatectomy, only wild-type mice exhibited the recovery of TRAIL expression on NK cells.	Poly I-C	31-39	chemokine (C-X-C motif) receptor 3	Mus musculus	112-117
29088306-10	2017	Although the administration of poly I:C, an inducer of interferon-gamma, increased hepatic CXCL9 levels in both CXCR3-/- and wild-type mice even after hepatectomy, only wild-type mice exhibited the recovery of TRAIL expression on NK cells.	Poly I-C	31-39	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	210-215
28746799-9	2017	Finally, we confirmed that in vivo injection of an anti-PD-L1 antibody or a Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid, effectively inhibited tumorigenesis under the IL-6-deficient condition.	Poly I-C	105-136	interleukin 6	Mus musculus	184-188
28429578-0	2017	Soy isoflavones enhance beta-defensin synthesis and secretion in endometrial epithelial cells with exposure to TLR3 agonist polyinosinic-polycytidylic acid.	Poly I-C	124-155	toll like receptor 3	Homo sapiens	111-115
28848054-6	2017	Poly(I:C) treatment induced PD-L1 expression on TNBC cells, and combined poly(I:C) and anti-PD-1 treatment prolonged metastasis-free survival in a neoadjuvant setting via the induction of a tumor-specific T-cell response.	Poly I-C	0-8	CD274 molecule	Homo sapiens	28-33
28601925-5	2017	Overall, addition of IFNgamma and the TLR7/8 agonist R848 during maturation was essential for the production of high levels of IL-12p70 which was further augmented by adding the TLR3 agonist poly I:C.	Poly I-C	191-199	interferon gamma	Homo sapiens	21-29
28601925-5	2017	Overall, addition of IFNgamma and the TLR7/8 agonist R848 during maturation was essential for the production of high levels of IL-12p70 which was further augmented by adding the TLR3 agonist poly I:C.	Poly I-C	191-199	toll like receptor 7	Homo sapiens	38-42
28601925-5	2017	Overall, addition of IFNgamma and the TLR7/8 agonist R848 during maturation was essential for the production of high levels of IL-12p70 which was further augmented by adding the TLR3 agonist poly I:C.	Poly I-C	191-199	toll like receptor 3	Homo sapiens	178-182
28601925-6	2017	In addition, the DC matured with IFNgamma, R848, and poly I:C also induced upregulation of several other pro-inflammatory and Th1-skewing cytokines/chemokines, co-stimulatory receptors, and the chemokine receptor CCR7.	Poly I-C	53-61	C-C motif chemokine receptor 7	Homo sapiens	213-217
28931666-5	2017	PNE treatment with poly I:C caused similar transient heightened responses to TRPA1 activation compared to untreated cells.Using the PNE neuronal model we observed both NGF and poly I:C mediated sensory neuronal hyperresponsiveness, representing potential neuro-inflammatory mechanisms associated with heightened nociceptive responses recognised in cough hypersensitivity syndrome.	Poly I-C	19-27	transient receptor potential cation channel subfamily A member 1	Homo sapiens	77-82
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	48-56	caspase 1	Homo sapiens	215-224
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	48-56	caspase 1	Homo sapiens	237-246
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	48-56	interleukin 1 beta	Homo sapiens	268-276
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	48-56	interleukin 18	Homo sapiens	281-286
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	48-56	NLR family pyrin domain containing 3	Homo sapiens	331-336
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	196-204	caspase 1	Homo sapiens	215-224
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	196-204	caspase 1	Homo sapiens	237-246
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	196-204	interleukin 1 beta	Homo sapiens	268-276
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	196-204	interleukin 18	Homo sapiens	281-286
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	196-204	NLR family pyrin domain containing 3	Homo sapiens	331-336
28266737-7	2017	The activation of keratinocyte NLRP3 inflammasome by transfected poly I:C was dependent on dsRNA-induced protein kinase (PKR) activation, and priming with type I interferons upregulated NLRP3 inflammasome activation through promoting PKR activation in poly I:C-transfected keratinocytes.	Poly I-C	65-73	NLR family pyrin domain containing 3	Homo sapiens	31-36
28266737-7	2017	The activation of keratinocyte NLRP3 inflammasome by transfected poly I:C was dependent on dsRNA-induced protein kinase (PKR) activation, and priming with type I interferons upregulated NLRP3 inflammasome activation through promoting PKR activation in poly I:C-transfected keratinocytes.	Poly I-C	65-73	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	121-124
28266737-7	2017	The activation of keratinocyte NLRP3 inflammasome by transfected poly I:C was dependent on dsRNA-induced protein kinase (PKR) activation, and priming with type I interferons upregulated NLRP3 inflammasome activation through promoting PKR activation in poly I:C-transfected keratinocytes.	Poly I-C	65-73	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	234-237
28835457-7	2017	The beta2 adrenoceptor agonists formoterol and salbutamol mediated suppression of IL-27p28 production, when triggered by zymosan/TLR2, LPS/TLR4, or R848/TLR7/8 activation, but selectively spared the polyinosinic-polycytidylic acid/TLR3 pathway.	Poly I-C	199-230	adrenergic receptor, beta 2	Mus musculus	4-22
28835457-7	2017	The beta2 adrenoceptor agonists formoterol and salbutamol mediated suppression of IL-27p28 production, when triggered by zymosan/TLR2, LPS/TLR4, or R848/TLR7/8 activation, but selectively spared the polyinosinic-polycytidylic acid/TLR3 pathway.	Poly I-C	199-230	interleukin 27	Mus musculus	82-90
28928438-7	2017	Moreover, ZYX knockdown reduced the expression of type I IFN and an interferon-inducible gene after stimulation with polyI:C or influenza A virus RNA.	Poly I-C	117-124	zyxin	Homo sapiens	10-13
28853490-6	2017	We found increased transcription and release of IL-26 protein after stimulation with the viral-related double stranded (ds) RNA polyinosinic-polycytidylic acid (poly-IC) and showed that this IL-26 release involved mitogen-activated protein (MAP) kinases and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).	Poly I-C	128-159	interleukin 26	Homo sapiens	48-53
28983294-0	2017	Lipoteichoic Acid of Probiotic Lactobacillus plantarum Attenuates Poly I:C-Induced IL-8 Production in Porcine Intestinal Epithelial Cells.	Poly I-C	66-74	C-X-C motif chemokine ligand 8	Sus scrofa	83-87
28983294-5	2017	Lp.LTA, but not lipoprotein or peptidoglycan from L. plantarum, exclusively suppressed poly I:C-induced IL-8 production.	Poly I-C	87-95	C-X-C motif chemokine ligand 8	Sus scrofa	104-108
28717003-2	2017	Double-stranded RNA and the synthetic analog polyinosinic:polycytidylic acid (poly(I:C)) bind and activate TLR3.	Poly I-C	78-87	toll like receptor 3	Homo sapiens	107-111
28717003-5	2017	In response to poly(I:C) addition, the metastatic IECs also induced the chemokine CXCL10 in a TLR3-, TRIF-, and IRF3-dependent manner but failed to produce IFNbeta.	Poly I-C	15-24	C-X-C motif chemokine ligand 10	Homo sapiens	82-88
28717003-5	2017	In response to poly(I:C) addition, the metastatic IECs also induced the chemokine CXCL10 in a TLR3-, TRIF-, and IRF3-dependent manner but failed to produce IFNbeta.	Poly I-C	15-24	toll like receptor 3	Homo sapiens	94-98
28717003-5	2017	In response to poly(I:C) addition, the metastatic IECs also induced the chemokine CXCL10 in a TLR3-, TRIF-, and IRF3-dependent manner but failed to produce IFNbeta.	Poly I-C	15-24	TIR domain containing adaptor molecule 1	Homo sapiens	101-105
28717003-5	2017	In response to poly(I:C) addition, the metastatic IECs also induced the chemokine CXCL10 in a TLR3-, TRIF-, and IRF3-dependent manner but failed to produce IFNbeta.	Poly I-C	15-24	interferon regulatory factor 3	Homo sapiens	112-116
28717003-7	2017	Endolysosomal acidification and the endosomal transporter protein UNC93B1 was required for poly(I:C)-induced CXCL10 production.	Poly I-C	91-100	unc-93 homolog B1, TLR signaling regulator	Homo sapiens	66-73
28717003-7	2017	Endolysosomal acidification and the endosomal transporter protein UNC93B1 was required for poly(I:C)-induced CXCL10 production.	Poly I-C	91-100	C-X-C motif chemokine ligand 10	Homo sapiens	109-115
28931666-5	2017	PNE treatment with poly I:C caused similar transient heightened responses to TRPA1 activation compared to untreated cells.Using the PNE neuronal model we observed both NGF and poly I:C mediated sensory neuronal hyperresponsiveness, representing potential neuro-inflammatory mechanisms associated with heightened nociceptive responses recognised in cough hypersensitivity syndrome.	Poly I-C	19-27	nerve growth factor	Homo sapiens	168-171
28898289-6	2017	TRIM32-mediated as well as poly(I:C)- and LPS-induced degradation of TRIF is inhibited by deficiency of TAX1BP1, a receptor for selective autophagy.	Poly I-C	27-36	toll-like receptor adaptor molecule 2	Mus musculus	69-73
28898289-6	2017	TRIM32-mediated as well as poly(I:C)- and LPS-induced degradation of TRIF is inhibited by deficiency of TAX1BP1, a receptor for selective autophagy.	Poly I-C	27-36	Tax1 (human T cell leukemia virus type I) binding protein 1	Mus musculus	104-111
28651122-8	2017	Using B16F1 cells or B16F1 cells deficient in IFN-gamma receptor (B16-IRFGRKO), we found that IFN-gamma alone and in synergy with the TLR3/IRF3 agonists, poly I:C, decreased B16F1 cell growth in significant correlation with increased ISG54 expression.	Poly I-C	154-162	interferon gamma	Mus musculus	46-55
28928676-10	2017	NR2A binding was elevated, while NR2B binding was unchanged, in all brain regions of polyI:C offspring overall.	Poly I-C	85-92	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	0-4
28928676-11	2017	Male, but not female, polyI:C offspring exhibited increased NMDAR channel and NR2A binding in the striatum overall, and increased NR2A binding in the cortex overall.	Poly I-C	22-29	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	78-82
28928676-11	2017	Male, but not female, polyI:C offspring exhibited increased NMDAR channel and NR2A binding in the striatum overall, and increased NR2A binding in the cortex overall.	Poly I-C	22-29	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	130-134
28662439-11	2017	IL-20 production from PBMCs was induced by Poly I:C and LPS but not with pro-inflammatory cytokines, such as TNF-alpha or IL-1.	Poly I-C	43-51	interleukin 20	Homo sapiens	0-5
28789986-5	2017	The ch25h genes showed different tissue expression patterns and differed in their expression after immune stimulation with lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (PolyI:C) and Spring Viremia Carp Virus (SVCV).	Poly I-C	149-180	cholesterol 25-hydroxylase	Danio rerio	4-9
28651122-8	2017	Using B16F1 cells or B16F1 cells deficient in IFN-gamma receptor (B16-IRFGRKO), we found that IFN-gamma alone and in synergy with the TLR3/IRF3 agonists, poly I:C, decreased B16F1 cell growth in significant correlation with increased ISG54 expression.	Poly I-C	154-162	interferon gamma	Mus musculus	94-103
28651122-9	2017	Moreover, IFN-gamma alone increased expression of the cell cycle inhibitor, p27Kip while IFN-gamma plus poly I:C increased cleaved Caspase-3 in B16 cells.	Poly I-C	104-112	caspase 3	Mus musculus	131-140
28747347-4	2017	TRIM8 deficiency leads to increased polyinosinic-polycytidylic acid- and LPS-triggered induction of downstream anti-microbial genes including TNF, Il6, Rantes, and Ifnb, evaluated serum cytokine levels, and increased susceptibility of mice to polyinosinic-polycytidylic acid- and LPS-induced inflammatory death as well as Salmonella typhimurium infection-induced loss of body weight and septic shock.	Poly I-C	36-67	tripartite motif-containing 8	Mus musculus	0-5
28747347-4	2017	TRIM8 deficiency leads to increased polyinosinic-polycytidylic acid- and LPS-triggered induction of downstream anti-microbial genes including TNF, Il6, Rantes, and Ifnb, evaluated serum cytokine levels, and increased susceptibility of mice to polyinosinic-polycytidylic acid- and LPS-induced inflammatory death as well as Salmonella typhimurium infection-induced loss of body weight and septic shock.	Poly I-C	36-67	tumor necrosis factor	Mus musculus	142-145
28747347-4	2017	TRIM8 deficiency leads to increased polyinosinic-polycytidylic acid- and LPS-triggered induction of downstream anti-microbial genes including TNF, Il6, Rantes, and Ifnb, evaluated serum cytokine levels, and increased susceptibility of mice to polyinosinic-polycytidylic acid- and LPS-induced inflammatory death as well as Salmonella typhimurium infection-induced loss of body weight and septic shock.	Poly I-C	36-67	interleukin 6	Mus musculus	147-150
28747347-4	2017	TRIM8 deficiency leads to increased polyinosinic-polycytidylic acid- and LPS-triggered induction of downstream anti-microbial genes including TNF, Il6, Rantes, and Ifnb, evaluated serum cytokine levels, and increased susceptibility of mice to polyinosinic-polycytidylic acid- and LPS-induced inflammatory death as well as Salmonella typhimurium infection-induced loss of body weight and septic shock.	Poly I-C	36-67	interferon beta 1, fibroblast	Mus musculus	164-168
28747347-4	2017	TRIM8 deficiency leads to increased polyinosinic-polycytidylic acid- and LPS-triggered induction of downstream anti-microbial genes including TNF, Il6, Rantes, and Ifnb, evaluated serum cytokine levels, and increased susceptibility of mice to polyinosinic-polycytidylic acid- and LPS-induced inflammatory death as well as Salmonella typhimurium infection-induced loss of body weight and septic shock.	Poly I-C	243-274	tripartite motif-containing 8	Mus musculus	0-5
28760879-4	2017	Virus-induced and polyinosinic-polycytidylic acid-induced activation of MDA5 were severely impaired in PACT-knockout cells and attenuated in PACT-knockdown cells, but they were potentiated when PACT was overexpressed.	Poly I-C	18-49	interferon induced with helicase C domain 1	Homo sapiens	72-76
28760879-4	2017	Virus-induced and polyinosinic-polycytidylic acid-induced activation of MDA5 were severely impaired in PACT-knockout cells and attenuated in PACT-knockdown cells, but they were potentiated when PACT was overexpressed.	Poly I-C	18-49	RB binding protein 6, ubiquitin ligase	Homo sapiens	103-107
28760879-4	2017	Virus-induced and polyinosinic-polycytidylic acid-induced activation of MDA5 were severely impaired in PACT-knockout cells and attenuated in PACT-knockdown cells, but they were potentiated when PACT was overexpressed.	Poly I-C	18-49	RB binding protein 6, ubiquitin ligase	Homo sapiens	141-145
28760879-4	2017	Virus-induced and polyinosinic-polycytidylic acid-induced activation of MDA5 were severely impaired in PACT-knockout cells and attenuated in PACT-knockdown cells, but they were potentiated when PACT was overexpressed.	Poly I-C	18-49	RB binding protein 6, ubiquitin ligase	Homo sapiens	141-145
28659477-6	2017	In a dual-luciferase reporter assay, WNV NS1 significantly inhibited the activation of the IFN-beta promoter after Sendai virus infection or poly(I C) treatment.	Poly I-C	141-150	influenza virus NS1A binding protein	Homo sapiens	41-44
28932081-10	2017	Further investigation of the mechanisms showed that EGCG treatment significantly enhanced the poly I:C-induced expression of IFN-regulatory factor 9 and several antiviral IFN-stimulated genes, including ISG15, ISG56, myxovirus resistance A, and 2"-5"-oligoadenylate synthetase 1, which encode the key antiviral elements in the IFN signaling pathway.	Poly I-C	94-102	ISG15 ubiquitin like modifier	Homo sapiens	203-208
28932081-10	2017	Further investigation of the mechanisms showed that EGCG treatment significantly enhanced the poly I:C-induced expression of IFN-regulatory factor 9 and several antiviral IFN-stimulated genes, including ISG15, ISG56, myxovirus resistance A, and 2"-5"-oligoadenylate synthetase 1, which encode the key antiviral elements in the IFN signaling pathway.	Poly I-C	94-102	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	210-215
28853260-8	2017	And VSV replication-inhibition bioassay revealed that nsp1 significantly inhibited typeIIFN antiviral activities induced by poly(I:C).	Poly I-C	124-132	SH2 domain containing 3A	Homo sapiens	54-58
28970832-5	2017	Upon Poly(I:C) injections, we observed increased thymic expressions of alpha-AChR, interferon-beta and chemokines such as CXCL13 and CCL21 leading to B-cell recruitment.	Poly I-C	5-14	interferon beta 1, fibroblast	Mus musculus	83-98
28970832-5	2017	Upon Poly(I:C) injections, we observed increased thymic expressions of alpha-AChR, interferon-beta and chemokines such as CXCL13 and CCL21 leading to B-cell recruitment.	Poly I-C	5-14	chemokine (C-X-C motif) ligand 13	Mus musculus	122-128
28659477-6	2017	In a dual-luciferase reporter assay, WNV NS1 significantly inhibited the activation of the IFN-beta promoter after Sendai virus infection or poly(I C) treatment.	Poly I-C	141-150	interferon alpha 1	Homo sapiens	91-94
28844021-6	2017	Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression.	Poly I-C	77-86	toll-like receptor adaptor molecule 2	Mus musculus	23-27
28790196-5	2017	Activation of the TRIF pathway by polyinosinic:polycytidylic acid [poly(I:C)] suppressed the increase in SCD1 abundance induced by palmitic acid or an HFD and subsequently prevented lipid accumulation in hepatocytes.	Poly I-C	34-65	toll-like receptor adaptor molecule 1	Mus musculus	18-22
28790196-5	2017	Activation of the TRIF pathway by polyinosinic:polycytidylic acid [poly(I:C)] suppressed the increase in SCD1 abundance induced by palmitic acid or an HFD and subsequently prevented lipid accumulation in hepatocytes.	Poly I-C	34-65	stearoyl-Coenzyme A desaturase 1	Mus musculus	105-109
28790196-5	2017	Activation of the TRIF pathway by polyinosinic:polycytidylic acid [poly(I:C)] suppressed the increase in SCD1 abundance induced by palmitic acid or an HFD and subsequently prevented lipid accumulation in hepatocytes.	Poly I-C	67-76	toll-like receptor adaptor molecule 1	Mus musculus	18-22
28790196-5	2017	Activation of the TRIF pathway by polyinosinic:polycytidylic acid [poly(I:C)] suppressed the increase in SCD1 abundance induced by palmitic acid or an HFD and subsequently prevented lipid accumulation in hepatocytes.	Poly I-C	67-76	stearoyl-Coenzyme A desaturase 1	Mus musculus	105-109
28844021-6	2017	Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression.	Poly I-C	77-86	C-X-C motif chemokine ligand 1	Homo sapiens	122-131
28844021-6	2017	Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression.	Poly I-C	77-86	chemokine (C-X-C motif) ligand 15	Mus musculus	133-137
28790362-4	2017	The TLR3 agonist poly (I:C) activated TLR3 pathway and inhibited tumor cells proliferation through caspase-dependent apoptosis.	Poly I-C	17-27	toll like receptor 3	Gallus gallus	4-8
28790362-4	2017	The TLR3 agonist poly (I:C) activated TLR3 pathway and inhibited tumor cells proliferation through caspase-dependent apoptosis.	Poly I-C	17-27	toll like receptor 3	Gallus gallus	38-42
27884591-6	2017	The TLR 3 ligand, polyinosinic-polycytidylic acid (poly(I:C)) significantly enhanced the secretion of thymic stromal lymphopoietin (TSLP), B lymphocyte stimulator (BLyS), IFNgamma-inducible protein 10 (IP-10), and macrophage inflammatory protein 1 alpha (MIP-1alpha) from the cells.	Poly I-C	18-49	thymic stromal lymphopoietin	Homo sapiens	132-136
27884591-6	2017	The TLR 3 ligand, polyinosinic-polycytidylic acid (poly(I:C)) significantly enhanced the secretion of thymic stromal lymphopoietin (TSLP), B lymphocyte stimulator (BLyS), IFNgamma-inducible protein 10 (IP-10), and macrophage inflammatory protein 1 alpha (MIP-1alpha) from the cells.	Poly I-C	18-49	TNF superfamily member 13b	Homo sapiens	139-162
27884591-6	2017	The TLR 3 ligand, polyinosinic-polycytidylic acid (poly(I:C)) significantly enhanced the secretion of thymic stromal lymphopoietin (TSLP), B lymphocyte stimulator (BLyS), IFNgamma-inducible protein 10 (IP-10), and macrophage inflammatory protein 1 alpha (MIP-1alpha) from the cells.	Poly I-C	18-49	TNF superfamily member 13b	Homo sapiens	164-168
27884591-6	2017	The TLR 3 ligand, polyinosinic-polycytidylic acid (poly(I:C)) significantly enhanced the secretion of thymic stromal lymphopoietin (TSLP), B lymphocyte stimulator (BLyS), IFNgamma-inducible protein 10 (IP-10), and macrophage inflammatory protein 1 alpha (MIP-1alpha) from the cells.	Poly I-C	18-49	C-X-C motif chemokine ligand 10	Homo sapiens	171-200
27884591-6	2017	The TLR 3 ligand, polyinosinic-polycytidylic acid (poly(I:C)) significantly enhanced the secretion of thymic stromal lymphopoietin (TSLP), B lymphocyte stimulator (BLyS), IFNgamma-inducible protein 10 (IP-10), and macrophage inflammatory protein 1 alpha (MIP-1alpha) from the cells.	Poly I-C	18-49	C-X-C motif chemokine ligand 10	Homo sapiens	202-207
27884591-6	2017	The TLR 3 ligand, polyinosinic-polycytidylic acid (poly(I:C)) significantly enhanced the secretion of thymic stromal lymphopoietin (TSLP), B lymphocyte stimulator (BLyS), IFNgamma-inducible protein 10 (IP-10), and macrophage inflammatory protein 1 alpha (MIP-1alpha) from the cells.	Poly I-C	18-49	C-C motif chemokine ligand 3	Homo sapiens	214-253
27884591-6	2017	The TLR 3 ligand, polyinosinic-polycytidylic acid (poly(I:C)) significantly enhanced the secretion of thymic stromal lymphopoietin (TSLP), B lymphocyte stimulator (BLyS), IFNgamma-inducible protein 10 (IP-10), and macrophage inflammatory protein 1 alpha (MIP-1alpha) from the cells.	Poly I-C	18-49	C-C motif chemokine ligand 3	Homo sapiens	255-265
27884591-7	2017	The inhibitor of JNK strongly reduced the poly(I:C)-induced TSLP-production.	Poly I-C	42-51	mitogen-activated protein kinase 8	Homo sapiens	17-20
27884591-7	2017	The inhibitor of JNK strongly reduced the poly(I:C)-induced TSLP-production.	Poly I-C	42-51	thymic stromal lymphopoietin	Homo sapiens	60-64
28630094-6	2017	Additionally, mitochondrial antiviral signaling protein-mediated signaling through cytosolic pattern recognition receptors was required for polyinosinic-polycytidylic acid-induced IFN-alpha/beta production and alloimmunization.	Poly I-C	140-171	interferon alpha	Mus musculus	180-189
28341273-4	2017	Therefore, we administered BCAA dissolved in the drinking water to Pkd1flox/flox:Mx1-Cre (cystic) mice from four to 22 weeks of age after polyinosinic-polycytidylic acid-induced conditional Pkd1 knockout at two weeks of age.	Poly I-C	138-169	polycystin 1, transient receptor potential channel interacting	Mus musculus	190-194
28844021-6	2017	Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression.	Poly I-C	77-86	chemokine (C-C motif) ligand 2	Mus musculus	139-144
28844021-6	2017	Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression.	Poly I-C	77-86	intercellular adhesion molecule 1	Mus musculus	146-152
28844021-6	2017	Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression.	Poly I-C	77-86	matrix metallopeptidase 9	Mus musculus	157-162
28844021-6	2017	Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression.	Poly I-C	77-86	TNF receptor-associated factor 6	Mus musculus	29-34
28844021-6	2017	Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression.	Poly I-C	77-86	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	36-40
28844021-6	2017	Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression.	Poly I-C	77-86	mitogen-activated protein kinase kinase kinase 7	Mus musculus	44-48
28844021-6	2017	Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression.	Poly I-C	77-86	interleukin 1 alpha	Mus musculus	95-104
28844021-6	2017	Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression.	Poly I-C	77-86	interleukin 1 beta	Mus musculus	106-114
28844021-6	2017	Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression.	Poly I-C	77-86	interleukin 6	Mus musculus	116-120
28409399-3	2017	RA, co-administered with the dsRNA mimic polyinosinic-polycytidylic acid (poly(I:C)), synergizes to induce a TRAIL (Tumor-Necrosis-Factor Related Apoptosis-Inducing Ligand)- dependent apoptotic program in breast cancer cells.	Poly I-C	41-72	TNF superfamily member 10	Homo sapiens	109-114
28409399-3	2017	RA, co-administered with the dsRNA mimic polyinosinic-polycytidylic acid (poly(I:C)), synergizes to induce a TRAIL (Tumor-Necrosis-Factor Related Apoptosis-Inducing Ligand)- dependent apoptotic program in breast cancer cells.	Poly I-C	41-72	TNF superfamily member 10	Homo sapiens	116-171
28409399-3	2017	RA, co-administered with the dsRNA mimic polyinosinic-polycytidylic acid (poly(I:C)), synergizes to induce a TRAIL (Tumor-Necrosis-Factor Related Apoptosis-Inducing Ligand)- dependent apoptotic program in breast cancer cells.	Poly I-C	74-83	TNF superfamily member 10	Homo sapiens	109-114
28409399-3	2017	RA, co-administered with the dsRNA mimic polyinosinic-polycytidylic acid (poly(I:C)), synergizes to induce a TRAIL (Tumor-Necrosis-Factor Related Apoptosis-Inducing Ligand)- dependent apoptotic program in breast cancer cells.	Poly I-C	74-83	TNF superfamily member 10	Homo sapiens	116-171
28487378-3	2017	Here, we demonstrated that, instead of stimulating type I IFN production, the EMCV-HB10 strain infection potently inhibited Sendai virus- and polyI:C-induced IRF3 phosphorylation and type I IFN production in HEK293T cells.	Poly I-C	142-149	interferon regulatory factor 3	Homo sapiens	158-162
28343946-8	2017	We further showed that intra-rectal poly(I:C) administration in mice reduces intestinal bacterial load and mucosal inflammation following Shigella flexneri 2a infection by inducing mCRAMP expression in the colonic epithelial cells.	Poly I-C	36-45	cathelicidin antimicrobial peptide	Mus musculus	181-187
28515281-8	2017	Also, we observed a markedly increased secretion of IL-12 and TNF-alpha by CXCL4-moDCs exclusively upon stimulation with polyinosinic-polycytidylic acid, R848, and CL075 ligands.	Poly I-C	121-152	tumor necrosis factor	Homo sapiens	62-71
28515281-8	2017	Also, we observed a markedly increased secretion of IL-12 and TNF-alpha by CXCL4-moDCs exclusively upon stimulation with polyinosinic-polycytidylic acid, R848, and CL075 ligands.	Poly I-C	121-152	platelet factor 4	Homo sapiens	75-80
28662082-6	2017	We first characterized an adjuvant system in vitro which consisted of two TLR ligands, poly I:C (TLR3) and Pam3CSK4 (TLR2), by evaluating its effects on B cell activation.	Poly I-C	87-95	toll-like receptor 3	Mus musculus	97-101
28487378-3	2017	Here, we demonstrated that, instead of stimulating type I IFN production, the EMCV-HB10 strain infection potently inhibited Sendai virus- and polyI:C-induced IRF3 phosphorylation and type I IFN production in HEK293T cells.	Poly I-C	142-149	interferon alpha 1	Homo sapiens	190-193
27677834-5	2017	In addition, IL-27 increased TLR3 expression in osteoclasts and enhanced poly(I:C)-mediated induction of IL-27 in these cells.	Poly I-C	73-82	interleukin 27	Homo sapiens	13-18
27677834-5	2017	In addition, IL-27 increased TLR3 expression in osteoclasts and enhanced poly(I:C)-mediated induction of IL-27 in these cells.	Poly I-C	73-82	interleukin 27	Homo sapiens	105-110
28427199-13	2017	The combinatorial treatment with polyI:C and anti-IL6 enhanced polyI:C-mediated anticancer activities through IL6/JAK2/STAT3 signalling, and apoptosis via TLR3-mediated caspase 3/8 pathway.	Poly I-C	63-70	interleukin 6	Homo sapiens	50-53
28427199-2	2017	PolyI:C, a TLR3 agonist, activates immune cells and regresses metastatic lung cancer in vivo.	Poly I-C	0-7	toll like receptor 3	Homo sapiens	11-15
28427199-5	2017	Notably, A549, NCI-H292 and NCI-H358 which are inducible by polyI:C, expressed low-to-medium level of TLR3 protein, and were susceptible to polyI:C treatment.	Poly I-C	140-147	toll like receptor 3	Homo sapiens	102-106
28427199-13	2017	The combinatorial treatment with polyI:C and anti-IL6 enhanced polyI:C-mediated anticancer activities through IL6/JAK2/STAT3 signalling, and apoptosis via TLR3-mediated caspase 3/8 pathway.	Poly I-C	63-70	interleukin 6	Homo sapiens	110-113
28427199-13	2017	The combinatorial treatment with polyI:C and anti-IL6 enhanced polyI:C-mediated anticancer activities through IL6/JAK2/STAT3 signalling, and apoptosis via TLR3-mediated caspase 3/8 pathway.	Poly I-C	63-70	Janus kinase 2	Homo sapiens	114-118
28427199-13	2017	The combinatorial treatment with polyI:C and anti-IL6 enhanced polyI:C-mediated anticancer activities through IL6/JAK2/STAT3 signalling, and apoptosis via TLR3-mediated caspase 3/8 pathway.	Poly I-C	63-70	signal transducer and activator of transcription 3	Homo sapiens	119-124
28363866-9	2017	Transfection of poly(I-C) enhanced IL8 and BST2 mRNA expression and inhibited HBsAg secretion from PLC/PRF/5 cells.	Poly I-C	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
28427199-10	2017	Treatment of A549 with a combination of polyI:C and anti-IL6 antibody significantly decreased IL6 production, and enhanced polyI:C-mediated killing and suppression of oncogenicity and metastasis.	Poly I-C	40-47	interleukin 6	Homo sapiens	94-97
28427199-10	2017	Treatment of A549 with a combination of polyI:C and anti-IL6 antibody significantly decreased IL6 production, and enhanced polyI:C-mediated killing and suppression of oncogenicity and metastasis.	Poly I-C	123-130	interleukin 6	Homo sapiens	57-60
28427199-11	2017	While polyI:C stimulated the phosphorylation of STAT3 and JAK2, blockade of these proteins enhanced polyI:C-mediated suppression of survival and metastasis.	Poly I-C	6-13	signal transducer and activator of transcription 3	Homo sapiens	48-53
28427199-11	2017	While polyI:C stimulated the phosphorylation of STAT3 and JAK2, blockade of these proteins enhanced polyI:C-mediated suppression of survival and metastasis.	Poly I-C	6-13	Janus kinase 2	Homo sapiens	58-62
28427199-12	2017	Taken together, polyI:C alone provoked apoptosis of lung cancer cells that express low-to-medium levels of functional TLR3 protein.	Poly I-C	16-23	toll like receptor 3	Homo sapiens	118-122
28427199-13	2017	The combinatorial treatment with polyI:C and anti-IL6 enhanced polyI:C-mediated anticancer activities through IL6/JAK2/STAT3 signalling, and apoptosis via TLR3-mediated caspase 3/8 pathway.	Poly I-C	33-40	interleukin 6	Homo sapiens	110-113
28427199-13	2017	The combinatorial treatment with polyI:C and anti-IL6 enhanced polyI:C-mediated anticancer activities through IL6/JAK2/STAT3 signalling, and apoptosis via TLR3-mediated caspase 3/8 pathway.	Poly I-C	33-40	Janus kinase 2	Homo sapiens	114-118
28427199-13	2017	The combinatorial treatment with polyI:C and anti-IL6 enhanced polyI:C-mediated anticancer activities through IL6/JAK2/STAT3 signalling, and apoptosis via TLR3-mediated caspase 3/8 pathway.	Poly I-C	33-40	signal transducer and activator of transcription 3	Homo sapiens	119-124
28427199-13	2017	The combinatorial treatment with polyI:C and anti-IL6 enhanced polyI:C-mediated anticancer activities through IL6/JAK2/STAT3 signalling, and apoptosis via TLR3-mediated caspase 3/8 pathway.	Poly I-C	33-40	toll like receptor 3	Homo sapiens	155-159
28411188-7	2017	We further demonstrated that Poly(I:C) treatment, but not LPS treatment, induces RKIP phosphorylation at S109.	Poly I-C	29-38	phosphatidylethanolamine binding protein 1	Mus musculus	81-85
28373582-3	2017	We found that in murine AIP (MRL/Mp mice treated with polyinosinic-polycytidylic acid) not only the pancreatic infiltration of immune cells but also the development of fibrosis were markedly reduced by the depletion of pDCs or blockade of type I IFN signaling; moreover, such treatment was accompanied by a marked reduction of pancreatic expression of IL-33.	Poly I-C	54-85	interleukin 33	Mus musculus	352-357
28373582-4	2017	Conversely, polyinosinic-polycytidylic acid-induced inflamed pancreatic tissue in murine AIP exhibited increased expression of type I IFNs and IL-33 (and downstream IL-33 cytokines such as IL-13 and TGF-beta1).	Poly I-C	12-43	interleukin 33	Mus musculus	143-148
28373582-4	2017	Conversely, polyinosinic-polycytidylic acid-induced inflamed pancreatic tissue in murine AIP exhibited increased expression of type I IFNs and IL-33 (and downstream IL-33 cytokines such as IL-13 and TGF-beta1).	Poly I-C	12-43	interleukin 33	Mus musculus	165-170
28373582-4	2017	Conversely, polyinosinic-polycytidylic acid-induced inflamed pancreatic tissue in murine AIP exhibited increased expression of type I IFNs and IL-33 (and downstream IL-33 cytokines such as IL-13 and TGF-beta1).	Poly I-C	12-43	interleukin 13	Mus musculus	189-194
28373582-4	2017	Conversely, polyinosinic-polycytidylic acid-induced inflamed pancreatic tissue in murine AIP exhibited increased expression of type I IFNs and IL-33 (and downstream IL-33 cytokines such as IL-13 and TGF-beta1).	Poly I-C	12-43	transforming growth factor, beta 1	Mus musculus	199-208
28493975-8	2017	Consistent with the activation of chTBK1, the interferon regulatory factor 3 (IRF3) and IFNbeta gene in CEFs were also up-regulated after challenge with ALV-J or polyI:C.	Poly I-C	162-169	interferon	Gallus gallus	46-56
28493975-8	2017	Consistent with the activation of chTBK1, the interferon regulatory factor 3 (IRF3) and IFNbeta gene in CEFs were also up-regulated after challenge with ALV-J or polyI:C.	Poly I-C	162-169	interferon regulatory factor 7	Gallus gallus	78-82
28493975-8	2017	Consistent with the activation of chTBK1, the interferon regulatory factor 3 (IRF3) and IFNbeta gene in CEFs were also up-regulated after challenge with ALV-J or polyI:C.	Poly I-C	162-169	interferon omega 1	Gallus gallus	88-95
28493975-9	2017	In contrast, the expression of IRF3 and IFNbeta in CEFs was significantly reduced by siRNA targeting the chTBK1 gene compared with a negative control (NC) during ALV-J infection or polyI:C transfection.	Poly I-C	181-188	interferon regulatory factor 7	Gallus gallus	31-35
28493975-9	2017	In contrast, the expression of IRF3 and IFNbeta in CEFs was significantly reduced by siRNA targeting the chTBK1 gene compared with a negative control (NC) during ALV-J infection or polyI:C transfection.	Poly I-C	181-188	interferon omega 1	Gallus gallus	40-47
28363866-9	2017	Transfection of poly(I-C) enhanced IL8 and BST2 mRNA expression and inhibited HBsAg secretion from PLC/PRF/5 cells.	Poly I-C	16-25	bone marrow stromal cell antigen 2	Homo sapiens	43-47
28363866-9	2017	Transfection of poly(I-C) enhanced IL8 and BST2 mRNA expression and inhibited HBsAg secretion from PLC/PRF/5 cells.	Poly I-C	16-25	heparan sulfate proteoglycan 2	Homo sapiens	99-102
28244106-13	2017	Moreover, seizures resulted in a profound (76%) elevation of extracellular glutamate in the CA1 of PIC-challenged but not saline-injected mice.	Poly I-C	99-102	carbonic anhydrase 1	Mus musculus	92-95
28279790-10	2017	The In vitro study by using primary spleen cells stimulated with polyI:C revealed a similar expression pattern to that in vivo studies, while the stimulation with beta-glucan or LPS, which normally induced expression of il17d mRNA in target cells in vitro in other animals, did not show apparent changes in the expression of il17d mRNA.	Poly I-C	65-72	interleukin 17D	Homo sapiens	220-225
28288940-3	2017	Lonchocarpine suppressed the expression of iNOS and proinflammatory cytokines in LPS or poly(I:C)-stimulated BV2 microglial cells.	Poly I-C	88-97	nitric oxide synthase 2, inducible	Mus musculus	43-47
27649928-3	2017	Intraperitoneally injected polyribocytidylic acid (poly (I:C)- (a ligand of TLR3) primed human umbilical cord-derived MSCs (hUC-MSCs) migrated to the inflamed colon and effectively improved clinical and pathological manifestations in colitic mice compared with mice treated with unstimulated hUC-MSCs (UCMs).	Poly I-C	51-61	toll like receptor 3	Homo sapiens	76-80
27649928-4	2017	Poly (I:C)-MSCs decreased a wide range of inflammatory cytokines and increased systemic interleukin-10 (IL-10) levels in colonic tissues.	Poly I-C	0-10	interleukin 10	Mus musculus	88-102
27649928-4	2017	Poly (I:C)-MSCs decreased a wide range of inflammatory cytokines and increased systemic interleukin-10 (IL-10) levels in colonic tissues.	Poly I-C	0-10	interleukin 10	Mus musculus	104-109
27649928-6	2017	Poly (I:C)-MSCs suppressed the proliferation of activated mesenteric lymph node (MLN) cells via the overproduction of prostaglandin E2 (PGE2) and upregulation of Jagged-1.	Poly I-C	0-10	jagged 1	Mus musculus	162-170
28438134-0	2017	Poly I:C induces collective migration of HaCaT keratinocytes via IL-8.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
28438134-5	2017	The systemic administration of polyriboinosinic-polyribocytidylic acid (poly I:C ; a substitute for viral dsRNA and a ligand of toll-like receptor 3), enhances wound healing in vivo.	Poly I-C	31-70	toll like receptor 3	Homo sapiens	128-148
28438134-5	2017	The systemic administration of polyriboinosinic-polyribocytidylic acid (poly I:C ; a substitute for viral dsRNA and a ligand of toll-like receptor 3), enhances wound healing in vivo.	Poly I-C	72-80	toll like receptor 3	Homo sapiens	128-148
28438134-8	2017	Poly I:C also increased IL-8 and bFGF production, and anti-IL-8 antibodies significantly inhibited the migration caused by poly I:C.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
28438134-8	2017	Poly I:C also increased IL-8 and bFGF production, and anti-IL-8 antibodies significantly inhibited the migration caused by poly I:C.	Poly I-C	0-8	fibroblast growth factor 2	Homo sapiens	33-37
28438134-8	2017	Poly I:C also increased IL-8 and bFGF production, and anti-IL-8 antibodies significantly inhibited the migration caused by poly I:C.	Poly I-C	123-131	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
28438134-10	2017	An immunofluorescence assay and enzyme-linked immunosorbent assay (ELISA) also revealed that poly I:C decreased E-cadherin protein levels and increased vimentin protein levels, and anti-IL-8 antibody reversed this effect.	Poly I-C	93-101	cadherin 1	Homo sapiens	112-122
28438134-10	2017	An immunofluorescence assay and enzyme-linked immunosorbent assay (ELISA) also revealed that poly I:C decreased E-cadherin protein levels and increased vimentin protein levels, and anti-IL-8 antibody reversed this effect.	Poly I-C	93-101	vimentin	Homo sapiens	152-160
28438134-12	2017	CONCLUSION: Our findings demonstrated that poly I:C accelerated collective HaCaT cell migration via autocrine/paracrine secretions of IL-8 and the subsequent incomplete epithelial-mesenchymal transition (EMT).	Poly I-C	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
28052863-5	2017	Poly(I:C) increased the production of IL-6, IL-8, monocyte chemoattractant protein-1, and ICAM-1.	Poly I-C	0-8	interleukin 6	Homo sapiens	38-42
28275135-4	2017	In addition, in a murine model of ILC2 expansion in the liver, polyinosinic-polycytidylic acid, an NK cell-activating agent, inhibited ILC2 proliferation, IL-5 and IL-13 production, and eosinophil recruitment.	Poly I-C	63-94	interleukin 5	Mus musculus	155-159
28275135-4	2017	In addition, in a murine model of ILC2 expansion in the liver, polyinosinic-polycytidylic acid, an NK cell-activating agent, inhibited ILC2 proliferation, IL-5 and IL-13 production, and eosinophil recruitment.	Poly I-C	63-94	interleukin 13	Mus musculus	164-169
28445962-2	2017	We describe a protein vector that selectively delivers synthetic dsRNA, polyinosinic/polycytidylic acid (polyIC), to prostate tumors by targeting prostate specific membrane antigen (PSMA), which is overexpressed on the surface of prostate cancer cells.The chimeric protein is built from the double stranded RNA (dsRNA) binding domain of PKR tethered to a single chain anti-PSMA antibody.	Poly I-C	72-103	folate hydrolase 1	Homo sapiens	146-180
28445962-2	2017	We describe a protein vector that selectively delivers synthetic dsRNA, polyinosinic/polycytidylic acid (polyIC), to prostate tumors by targeting prostate specific membrane antigen (PSMA), which is overexpressed on the surface of prostate cancer cells.The chimeric protein is built from the double stranded RNA (dsRNA) binding domain of PKR tethered to a single chain anti-PSMA antibody.	Poly I-C	72-103	folate hydrolase 1	Homo sapiens	182-186
28445962-2	2017	We describe a protein vector that selectively delivers synthetic dsRNA, polyinosinic/polycytidylic acid (polyIC), to prostate tumors by targeting prostate specific membrane antigen (PSMA), which is overexpressed on the surface of prostate cancer cells.The chimeric protein is built from the double stranded RNA (dsRNA) binding domain of PKR tethered to a single chain anti-PSMA antibody.	Poly I-C	105-111	folate hydrolase 1	Homo sapiens	146-180
28445962-2	2017	We describe a protein vector that selectively delivers synthetic dsRNA, polyinosinic/polycytidylic acid (polyIC), to prostate tumors by targeting prostate specific membrane antigen (PSMA), which is overexpressed on the surface of prostate cancer cells.The chimeric protein is built from the double stranded RNA (dsRNA) binding domain of PKR tethered to a single chain anti-PSMA antibody.	Poly I-C	105-111	folate hydrolase 1	Homo sapiens	182-186
28445962-2	2017	We describe a protein vector that selectively delivers synthetic dsRNA, polyinosinic/polycytidylic acid (polyIC), to prostate tumors by targeting prostate specific membrane antigen (PSMA), which is overexpressed on the surface of prostate cancer cells.The chimeric protein is built from the double stranded RNA (dsRNA) binding domain of PKR tethered to a single chain anti-PSMA antibody.	Poly I-C	105-111	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	337-340
28445962-2	2017	We describe a protein vector that selectively delivers synthetic dsRNA, polyinosinic/polycytidylic acid (polyIC), to prostate tumors by targeting prostate specific membrane antigen (PSMA), which is overexpressed on the surface of prostate cancer cells.The chimeric protein is built from the double stranded RNA (dsRNA) binding domain of PKR tethered to a single chain anti-PSMA antibody.	Poly I-C	105-111	folate hydrolase 1	Homo sapiens	373-377
28052863-5	2017	Poly(I:C) increased the production of IL-6, IL-8, monocyte chemoattractant protein-1, and ICAM-1.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
28052863-5	2017	Poly(I:C) increased the production of IL-6, IL-8, monocyte chemoattractant protein-1, and ICAM-1.	Poly I-C	0-8	C-C motif chemokine ligand 2	Homo sapiens	50-84
28052863-5	2017	Poly(I:C) increased the production of IL-6, IL-8, monocyte chemoattractant protein-1, and ICAM-1.	Poly I-C	0-8	intercellular adhesion molecule 1	Homo sapiens	90-96
28052863-6	2017	Poly(I:C) also induced robust activation of ERK1/2 and NF-kappaB.	Poly I-C	0-8	mitogen-activated protein kinase 3	Homo sapiens	44-50
26456691-6	2017	The potency of LCs to enhance CD8+ T-cell responses could be further increased through activation of LCs with the toll-like receptor 3 ligand polyinosinic:polycytidylic acid (pI:C).	Poly I-C	142-173	CD8a molecule	Homo sapiens	30-33
28052863-6	2017	Poly(I:C) also induced robust activation of ERK1/2 and NF-kappaB.	Poly I-C	0-8	nuclear factor kappa B subunit 1	Homo sapiens	55-64
28052863-7	2017	Knockdown of Toll-like receptor 3 (TLR3) or Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta (TRIF) suppressed ERK1/2 and NF-kappaB p65 phosphorylation and reduced inflammatory mediator production induced by poly(I:C).	Poly I-C	222-230	toll like receptor 3	Homo sapiens	13-33
28052863-7	2017	Knockdown of Toll-like receptor 3 (TLR3) or Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta (TRIF) suppressed ERK1/2 and NF-kappaB p65 phosphorylation and reduced inflammatory mediator production induced by poly(I:C).	Poly I-C	222-230	TIR domain containing adaptor molecule 1	Homo sapiens	108-112
28052863-7	2017	Knockdown of Toll-like receptor 3 (TLR3) or Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta (TRIF) suppressed ERK1/2 and NF-kappaB p65 phosphorylation and reduced inflammatory mediator production induced by poly(I:C).	Poly I-C	222-230	RELA proto-oncogene, NF-kB subunit	Homo sapiens	146-149
28052863-10	2017	NF-kappaB p65 intranuclear translocation induced by the TLR4 agonist was reduced by inhibition of p50 migration; however, poly(I:C)-induced p65 translocation was not, although the p65/p50 heterodimer is present in AVICs.	Poly I-C	122-131	RELA proto-oncogene, NF-kB subunit	Homo sapiens	0-13
28052863-10	2017	NF-kappaB p65 intranuclear translocation induced by the TLR4 agonist was reduced by inhibition of p50 migration; however, poly(I:C)-induced p65 translocation was not, although the p65/p50 heterodimer is present in AVICs.	Poly I-C	122-131	toll like receptor 4	Homo sapiens	56-60
28052863-10	2017	NF-kappaB p65 intranuclear translocation induced by the TLR4 agonist was reduced by inhibition of p50 migration; however, poly(I:C)-induced p65 translocation was not, although the p65/p50 heterodimer is present in AVICs.	Poly I-C	122-131	RELA proto-oncogene, NF-kB subunit	Homo sapiens	10-13
28052863-10	2017	NF-kappaB p65 intranuclear translocation induced by the TLR4 agonist was reduced by inhibition of p50 migration; however, poly(I:C)-induced p65 translocation was not, although the p65/p50 heterodimer is present in AVICs.	Poly I-C	122-131	RELA proto-oncogene, NF-kB subunit	Homo sapiens	140-143
28052863-11	2017	Poly(I:C) upregulates the production of multiple inflammatory mediators through the TLR3-TRIF-NF-kappaB pathway in human AVICs.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	84-88
28052863-11	2017	Poly(I:C) upregulates the production of multiple inflammatory mediators through the TLR3-TRIF-NF-kappaB pathway in human AVICs.	Poly I-C	0-8	TIR domain containing adaptor molecule 1	Homo sapiens	89-93
28052863-11	2017	Poly(I:C) upregulates the production of multiple inflammatory mediators through the TLR3-TRIF-NF-kappaB pathway in human AVICs.	Poly I-C	0-8	nuclear factor kappa B subunit 1	Homo sapiens	94-103
28109979-0	2017	Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-beta-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.	Poly I-C	159-190	interferon induced protein 35	Homo sapiens	0-35
28148787-4	2017	Type I IFN production induced by poly I C or Sendai virus (SeV) was suppressed by the SARS-CoV N protein.	Poly I-C	33-41	interferon alpha 1	Homo sapiens	7-10
27897321-0	2017	Polyinosinic-polycytidylic acid (poly(I:C)) attenuates imiquimod-induced skin inflammation in mice by increasing cutaneous PD-L1 expression.	Poly I-C	0-31	CD274 antigen	Mus musculus	123-128
27897321-0	2017	Polyinosinic-polycytidylic acid (poly(I:C)) attenuates imiquimod-induced skin inflammation in mice by increasing cutaneous PD-L1 expression.	Poly I-C	33-43	CD274 antigen	Mus musculus	123-128
28250157-2	2017	We find that using APC pretreated ex vivo with TLR agonists, polyinosinic-polycytidylic acid and CpG, to prime naive CD4 T cells in vivo, restores their ability to expand and become germinal center T follicular helpers and enhances B cell IgG Ab production.	Poly I-C	61-92	CD4 antigen	Mus musculus	117-120
28159912-8	2017	Finally, we present evidence that, in human HACAT cells, the poly(I:C)-dependent phosphorylation of TBK1 at Ser172 involves a novel TBK1-activating kinase(s).	Poly I-C	61-70	TANK binding kinase 1	Homo sapiens	100-104
28159912-8	2017	Finally, we present evidence that, in human HACAT cells, the poly(I:C)-dependent phosphorylation of TBK1 at Ser172 involves a novel TBK1-activating kinase(s).	Poly I-C	61-70	TANK binding kinase 1	Homo sapiens	132-136
28109979-0	2017	Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-beta-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.	Poly I-C	159-190	interferon induced protein 35	Homo sapiens	37-42
28109979-0	2017	Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-beta-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.	Poly I-C	159-190	interferon beta 1	Homo sapiens	65-73
28109979-0	2017	Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-beta-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.	Poly I-C	159-190	signal transducer and activator of transcription 1	Homo sapiens	89-94
28109979-0	2017	Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-beta-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.	Poly I-C	159-190	DExD/H-box helicase 58	Homo sapiens	95-100
28109979-0	2017	Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-beta-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.	Poly I-C	159-190	C-X-C motif chemokine ligand 10	Homo sapiens	101-107
28109979-0	2017	Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-beta-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.	Poly I-C	159-190	C-C motif chemokine ligand 5	Homo sapiens	108-112
28109979-4	2017	In the present study, we found that the expression of IFI35 was induced by a Toll-like receptor 3 (TLR3) ligand polyinosinic-polycytidylic acid (poly IC) in U373MG human astrocytoma cells.	Poly I-C	112-143	interferon induced protein 35	Homo sapiens	54-59
28109979-4	2017	In the present study, we found that the expression of IFI35 was induced by a Toll-like receptor 3 (TLR3) ligand polyinosinic-polycytidylic acid (poly IC) in U373MG human astrocytoma cells.	Poly I-C	112-143	toll like receptor 3	Homo sapiens	77-97
28109979-4	2017	In the present study, we found that the expression of IFI35 was induced by a Toll-like receptor 3 (TLR3) ligand polyinosinic-polycytidylic acid (poly IC) in U373MG human astrocytoma cells.	Poly I-C	112-143	toll like receptor 3	Homo sapiens	99-103
28292465-10	2017	DISCUSSION: LPS and poly(I:C) induces insulin resistance and increases amino acid uptake in human primary trophoblast cells.	Poly I-C	20-29	insulin	Homo sapiens	38-45
27834952-3	2017	Here, we demonstrate that CD11b+Ly6G+ cells respond to polyI:C and exhibit tumoricidal activity in an EL4 tumor implant model.	Poly I-C	55-62	integrin subunit alpha M	Homo sapiens	26-31
27834952-4	2017	PolyI:C-induced inhibition of tumor growth was attributed to caspase-8/3 cascade activation in tumor cells that occurred independently of CD8alpha+/CD103+ dendritic cells (DCs) and CTLs.	Poly I-C	0-7	caspase 8	Homo sapiens	61-70
27834952-4	2017	PolyI:C-induced inhibition of tumor growth was attributed to caspase-8/3 cascade activation in tumor cells that occurred independently of CD8alpha+/CD103+ dendritic cells (DCs) and CTLs.	Poly I-C	0-7	CD8a molecule	Homo sapiens	138-146
27834952-5	2017	CD11b+Ly6G+ cells was essential for the antitumor effect because depletion of CD11b+Ly6G+ cells totally abrogated tumor regression and caspase activation after polyI:C treatment.	Poly I-C	160-167	integrin subunit alpha M	Homo sapiens	0-5
27834952-5	2017	CD11b+Ly6G+ cells was essential for the antitumor effect because depletion of CD11b+Ly6G+ cells totally abrogated tumor regression and caspase activation after polyI:C treatment.	Poly I-C	160-167	integrin subunit alpha M	Homo sapiens	78-83
27834952-6	2017	CD11b+Ly6G+ cells that had been activated with polyI:C showed cytotoxicity and inhibited tumor growth through the production of reactive oxygen species (ROS)/reactive nitrogen species (RNS).	Poly I-C	47-54	integrin subunit alpha M	Homo sapiens	0-5
27834952-8	2017	Thus, our results suggest that polyI:C activates the TLR3/TICAM-1 and IFNAR signaling pathways in CD11b+Ly6G+ cells in tumors, thereby eliciting their antitumor activity, independent of those in CD8alpha+/CD103+ DCs that prime CTLs.	Poly I-C	31-38	toll like receptor 3	Homo sapiens	53-57
27834952-8	2017	Thus, our results suggest that polyI:C activates the TLR3/TICAM-1 and IFNAR signaling pathways in CD11b+Ly6G+ cells in tumors, thereby eliciting their antitumor activity, independent of those in CD8alpha+/CD103+ DCs that prime CTLs.	Poly I-C	31-38	TIR domain containing adaptor molecule 1	Homo sapiens	58-65
27834952-8	2017	Thus, our results suggest that polyI:C activates the TLR3/TICAM-1 and IFNAR signaling pathways in CD11b+Ly6G+ cells in tumors, thereby eliciting their antitumor activity, independent of those in CD8alpha+/CD103+ DCs that prime CTLs.	Poly I-C	31-38	integrin subunit alpha M	Homo sapiens	98-103
27834952-8	2017	Thus, our results suggest that polyI:C activates the TLR3/TICAM-1 and IFNAR signaling pathways in CD11b+Ly6G+ cells in tumors, thereby eliciting their antitumor activity, independent of those in CD8alpha+/CD103+ DCs that prime CTLs.	Poly I-C	31-38	CD8a molecule	Homo sapiens	195-203
28394395-4	2017	The results showed that the induction of the expression of IL1B, IL6 and CXCLi2 by poly I:C, LPS, and CpG-ODN were suppressed by Bay11-7085, but not by tanshinone IIA.	Poly I-C	83-91	interleukin 1 beta	Homo sapiens	59-63
28394395-4	2017	The results showed that the induction of the expression of IL1B, IL6 and CXCLi2 by poly I:C, LPS, and CpG-ODN were suppressed by Bay11-7085, but not by tanshinone IIA.	Poly I-C	83-91	interleukin 6	Homo sapiens	65-68
28141795-3	2017	Here we demonstrated that MAVS signaling existed and mediated poly(I:C)-induced inflammation in the brain.	Poly I-C	62-71	mitochondrial antiviral signaling protein	Homo sapiens	26-30
28138113-4	2017	Methods: Western blot analysis of C1q in the brain regions from adult offspring after prenatal poly(I:C) (5.0 mg/kg/day from E12 to E17) exposure was performed.	Poly I-C	95-103	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	34-37
28246473-8	2017	Administration of poly I:C dramatically protected against DSS-induced colitis, as demonstrated by less body weight loss, lower disease activity index score, longer colon length, colonic MPO activity, and improved macroscopic and histological scores.	Poly I-C	18-26	myeloperoxidase	Mus musculus	186-189
28246473-10	2017	The mRNA and protein expressions of TJ protein, zo-1, occludin and claudin-1 were also found to be significantly enhanced in the poly I:C group, as determined by immunohistochemistry/immunofluorescence, Western blot and RT-qPCR.	Poly I-C	129-137	tight junction protein 1	Mus musculus	48-52
28246473-10	2017	The mRNA and protein expressions of TJ protein, zo-1, occludin and claudin-1 were also found to be significantly enhanced in the poly I:C group, as determined by immunohistochemistry/immunofluorescence, Western blot and RT-qPCR.	Poly I-C	129-137	occludin	Mus musculus	54-62
28246473-10	2017	The mRNA and protein expressions of TJ protein, zo-1, occludin and claudin-1 were also found to be significantly enhanced in the poly I:C group, as determined by immunohistochemistry/immunofluorescence, Western blot and RT-qPCR.	Poly I-C	129-137	claudin 1	Mus musculus	67-76
28246473-11	2017	By contrast, poly I:C pretreatment markedly reversed the DSS-induced up-regulated expressions of the inflammatory cytokines TNF-alpha, IL-17 and IFN-gamma.	Poly I-C	13-21	tumor necrosis factor	Mus musculus	124-133
28246473-11	2017	By contrast, poly I:C pretreatment markedly reversed the DSS-induced up-regulated expressions of the inflammatory cytokines TNF-alpha, IL-17 and IFN-gamma.	Poly I-C	13-21	interleukin 17A	Mus musculus	135-140
28246473-11	2017	By contrast, poly I:C pretreatment markedly reversed the DSS-induced up-regulated expressions of the inflammatory cytokines TNF-alpha, IL-17 and IFN-gamma.	Poly I-C	13-21	interferon gamma	Mus musculus	145-154
28077651-7	2017	In vivo, poly(I C)-induced neutrophilia and mucosal chemokine production are blocked by a small-molecule BRD4 bromodomain inhibitor.	Poly I-C	9-18	bromodomain containing 4	Homo sapiens	105-109
28069554-6	2017	Herein, we aimed to develop a liposomal carrier system co-encapsulating TLR3 (polyinosinic-polycytidylic acid; poly(I:C)) and TLR9 (oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs; CpG ODN) ligands as immunoadjuvants together with protein antigen.	Poly I-C	78-109	toll-like receptor 3	Mus musculus	72-76
27207173-9	2017	Poly(I:C), the well-known TLR3 agonist, is also able by itself to induce MG symptoms in mice associated with early thymic changes as observed in human MG.	Poly I-C	0-9	toll-like receptor 3	Mus musculus	26-30
27594385-0	2017	Poly I:C primes the suppressive function of human palatine tonsil-derived MSCs against Th17 differentiation by increasing PD-L1 expression.	Poly I-C	0-8	CD274 molecule	Homo sapiens	122-127
28157388-5	2017	At 6 and 24 h after stimulation with poly I:C (early and late phases, respectively) treated cultures contained significantly higher concentrations of IFN-lambda1 in the culture supernatant, and significantly higher IFN-lambda1 and IFN-lambda2 mRNA levels, than controls.	Poly I-C	37-45	interferon lambda 1	Homo sapiens	150-161
28157388-5	2017	At 6 and 24 h after stimulation with poly I:C (early and late phases, respectively) treated cultures contained significantly higher concentrations of IFN-lambda1 in the culture supernatant, and significantly higher IFN-lambda1 and IFN-lambda2 mRNA levels, than controls.	Poly I-C	37-45	interferon lambda 1	Homo sapiens	215-226
28157388-5	2017	At 6 and 24 h after stimulation with poly I:C (early and late phases, respectively) treated cultures contained significantly higher concentrations of IFN-lambda1 in the culture supernatant, and significantly higher IFN-lambda1 and IFN-lambda2 mRNA levels, than controls.	Poly I-C	37-45	interferon lambda 2	Homo sapiens	231-242
27861803-3	2017	Here, we found that polyinosinic-polycytidylic acid (poly(I:C)) strongly promoted the accumulation of P14 TCR-transgenic CD8+ TRM cells in SGs in an alpha4 beta1 integrin-dependent manner.	Poly I-C	20-51	CD8a molecule	Homo sapiens	121-124
27861803-3	2017	Here, we found that polyinosinic-polycytidylic acid (poly(I:C)) strongly promoted the accumulation of P14 TCR-transgenic CD8+ TRM cells in SGs in an alpha4 beta1 integrin-dependent manner.	Poly I-C	20-51	tremor	Mus musculus	126-129
27861803-3	2017	Here, we found that polyinosinic-polycytidylic acid (poly(I:C)) strongly promoted the accumulation of P14 TCR-transgenic CD8+ TRM cells in SGs in an alpha4 beta1 integrin-dependent manner.	Poly I-C	53-62	CD8a molecule	Homo sapiens	121-124
27861803-3	2017	Here, we found that polyinosinic-polycytidylic acid (poly(I:C)) strongly promoted the accumulation of P14 TCR-transgenic CD8+ TRM cells in SGs in an alpha4 beta1 integrin-dependent manner.	Poly I-C	53-62	tremor	Mus musculus	126-129
27873323-5	2017	Furthermore, CD40-B cells produce less inflammatory mediators, such as IL-12 and type I interferon, and increasing inflammation by coadministration of polyriboinosinic-polyribocytidylic acid with CD40-B-cell immunization allowed for the generation of long-lived and functional CD8+ memory T cells.	Poly I-C	151-190	CD40 antigen	Mus musculus	13-17
27594385-4	2017	Additionally, polyinosinic-polycytidylic acid (poly I:C), a Toll-like receptor 3 (TLR3) ligand, increased PD-L1 expression on T-MSCs.	Poly I-C	14-45	toll like receptor 3	Homo sapiens	60-80
27594385-4	2017	Additionally, polyinosinic-polycytidylic acid (poly I:C), a Toll-like receptor 3 (TLR3) ligand, increased PD-L1 expression on T-MSCs.	Poly I-C	14-45	toll like receptor 3	Homo sapiens	82-86
27594385-4	2017	Additionally, polyinosinic-polycytidylic acid (poly I:C), a Toll-like receptor 3 (TLR3) ligand, increased PD-L1 expression on T-MSCs.	Poly I-C	14-45	CD274 molecule	Homo sapiens	106-111
27594385-4	2017	Additionally, polyinosinic-polycytidylic acid (poly I:C), a Toll-like receptor 3 (TLR3) ligand, increased PD-L1 expression on T-MSCs.	Poly I-C	47-55	toll like receptor 3	Homo sapiens	60-80
27594385-4	2017	Additionally, polyinosinic-polycytidylic acid (poly I:C), a Toll-like receptor 3 (TLR3) ligand, increased PD-L1 expression on T-MSCs.	Poly I-C	47-55	toll like receptor 3	Homo sapiens	82-86
27594385-4	2017	Additionally, polyinosinic-polycytidylic acid (poly I:C), a Toll-like receptor 3 (TLR3) ligand, increased PD-L1 expression on T-MSCs.	Poly I-C	47-55	CD274 molecule	Homo sapiens	106-111
27567430-4	2017	We postulated that TLR2 priming (via Pam3Csk4) would inhibit TLR4-mediated responses while TLR3 priming (via Poly I:C) would enhance subsequent TLR4-inflammatory signaling.	Poly I-C	109-117	toll like receptor 3	Homo sapiens	91-95
27567430-4	2017	We postulated that TLR2 priming (via Pam3Csk4) would inhibit TLR4-mediated responses while TLR3 priming (via Poly I:C) would enhance subsequent TLR4-inflammatory signaling.	Poly I-C	109-117	toll like receptor 4	Homo sapiens	144-148
27567430-11	2017	Poly I:C priming induced interferon regulatory factor 7, leading to enhancement of interferon production.	Poly I-C	0-8	interferon regulatory factor 7	Homo sapiens	25-55
28000161-8	2017	Intrathecal administration of Poly (I:C), a TLR3 agonist, significantly increases the activation of microglial autophagy, whereas TLR3 knockdown markedly inhibits L5 SNL-induced microglial autophagy.	Poly I-C	30-39	toll-like receptor 3	Rattus norvegicus	44-48
27567430-12	2017	Finally, both Poly I:C and LPS priming induced significant changes in receptor-interacting serine/threonine-protein kinase 1 activity.	Poly I-C	14-22	receptor interacting serine/threonine kinase 1	Homo sapiens	70-124
27872096-0	2017	PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors.	Poly I-C	0-7	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-41
28110779-5	2017	Briefly, IFN-beta expression induced by TGEV infection is delayed with respect to that induced by poly(I:C) transfection.	Poly I-C	98-107	interferon alpha 1	Homo sapiens	9-12
28115915-4	2017	In a study in vitro, we have shown that corticosteroids plus long-acting beta2-agonists (LABAs) attenuate the upregulation of PD-L1 on airway epithelial cells stimulated with an analog of viral double-stranded RNA, polyinosinic-polycytidylic acid (poly I:C).	Poly I-C	215-246	hemoglobin, beta adult minor chain	Mus musculus	73-78
28115915-4	2017	In a study in vitro, we have shown that corticosteroids plus long-acting beta2-agonists (LABAs) attenuate the upregulation of PD-L1 on airway epithelial cells stimulated with an analog of viral double-stranded RNA, polyinosinic-polycytidylic acid (poly I:C).	Poly I-C	215-246	CD274 antigen	Mus musculus	126-131
28115915-10	2017	Although the upregulation of PD-L1 by high dose poly I:C was suppressed by ciclesonide plus indacaterol, neutrophilia and increased KC, MIP-1beta, and IL-6 in BALF were not attenuated.	Poly I-C	48-56	CD274 antigen	Mus musculus	29-34
27784631-4	2017	FAM26F has also been found to be upregulated by various stimulants such as polyI:C, LPS, INF gamma and TNF alpha, and via various anticipated pathways including TLR3, TLR4 IFN-beta and Dectin-1.	Poly I-C	75-82	calcium homeostasis modulator family member 6	Homo sapiens	0-6
27872096-5	2017	Remarkably, polyI:C and CpG was superior to combined PD-1/CTLA-4 blockade in sensitizing tumors to anti-ErbB2 mAb therapy.	Poly I-C	12-19	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-109
27872096-6	2017	Local injection of CpG and polyI:C in a primary tumor significantly enhanced the activity of systemic anti-ErbB2 mAb against a distant untreated tumor.	Poly I-C	27-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	107-112
27956531-8	2017	Challenge with polyinosinic-polycytidylic acid results in a rapid and strong downregulation of intestinal Clr-a expression in contrast to the upregulation of Clr-f, a close relative of Clr-a, that also is specifically expressed by the intestinal epithelium and acts as a ligand of the inhibitory Nkrp1g receptor.	Poly I-C	15-46	C-type lectin domain family 2, member e	Mus musculus	106-111
27956531-8	2017	Challenge with polyinosinic-polycytidylic acid results in a rapid and strong downregulation of intestinal Clr-a expression in contrast to the upregulation of Clr-f, a close relative of Clr-a, that also is specifically expressed by the intestinal epithelium and acts as a ligand of the inhibitory Nkrp1g receptor.	Poly I-C	15-46	C-type lectin domain family 2, member h	Mus musculus	158-163
27956531-8	2017	Challenge with polyinosinic-polycytidylic acid results in a rapid and strong downregulation of intestinal Clr-a expression in contrast to the upregulation of Clr-f, a close relative of Clr-a, that also is specifically expressed by the intestinal epithelium and acts as a ligand of the inhibitory Nkrp1g receptor.	Poly I-C	15-46	C-type lectin domain family 2, member e	Mus musculus	185-190
27956531-10	2017	Downregulation upon polyinosinic-polycytidylic acid challenge and expression by crypt cells clearly distinguish Clr-a from the likewise intestinal epithelium-restricted Clr-f, pointing to a nonredundant function of these highly related C-type lectin-like molecules in the context of intestinal immunosurveillance.	Poly I-C	20-51	C-type lectin domain family 2, member e	Mus musculus	112-117
28794402-4	2017	We have previously reported TLR3/IFN-beta/retinoic acid-inducible gene-I (RIG-I)/CCL5 and TLR3/IFN-beta/melanoma differentiation-associated gene 5 (MDA5)/CXCL10 axes in cultured normal human mesangial cells treated with polyinosinic-polycytidylic acid (poly IC), a synthetic double-stranded RNA that is sensed by TLR3.	Poly I-C	220-251	DExD/H-box helicase 58	Homo sapiens	28-72
27895126-3	2017	Previously, we have shown that poly(I:C) stimulates lung fibroblasts to accumulate an extracellular matrix (ECM), enriched in hyaluronan (HA) and its binding partner versican, which promotes monocyte adhesion.	Poly I-C	31-39	versican	Mus musculus	166-174
27895126-4	2017	In the current study, we aimed to determine the in vivo role of versican in mediating inflammatory responses in poly(I:C)-induced lung inflammation using a tamoxifen-inducible versican-deficient mouse model (Vcan-/- mice).	Poly I-C	112-121	versican	Mus musculus	64-72
27895126-5	2017	In C57Bl/6 mice, poly(I:C) instillation significantly increased accumulation of versican and HA, especially in the perivascular and peribronchial regions, which were enriched in infiltrating leukocytes.	Poly I-C	17-26	versican	Mus musculus	80-88
27895126-7	2017	Poly(I:C) stimulation of lung fibroblasts isolated from control mice generated HA-enriched cable structures in the ECM, providing a substrate for monocytic cells in vitro, whereas lung fibroblasts from Vcan-/- mice did not.	Poly I-C	0-8	versican	Mus musculus	202-206
27324793-6	2017	IFN-gamma showed limited effects on TGF-alpha and polyI:C-induced activation of epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase (ERK).	Poly I-C	50-57	interferon gamma	Homo sapiens	0-9
27324793-6	2017	IFN-gamma showed limited effects on TGF-alpha and polyI:C-induced activation of epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase (ERK).	Poly I-C	50-57	epidermal growth factor receptor	Homo sapiens	80-112
27324793-6	2017	IFN-gamma showed limited effects on TGF-alpha and polyI:C-induced activation of epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase (ERK).	Poly I-C	50-57	epidermal growth factor receptor	Homo sapiens	114-118
27324793-6	2017	IFN-gamma showed limited effects on TGF-alpha and polyI:C-induced activation of epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase (ERK).	Poly I-C	50-57	mitogen-activated protein kinase 1	Homo sapiens	124-161
27324793-6	2017	IFN-gamma showed limited effects on TGF-alpha and polyI:C-induced activation of epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase (ERK).	Poly I-C	50-57	mitogen-activated protein kinase 1	Homo sapiens	163-166
28794402-4	2017	We have previously reported TLR3/IFN-beta/retinoic acid-inducible gene-I (RIG-I)/CCL5 and TLR3/IFN-beta/melanoma differentiation-associated gene 5 (MDA5)/CXCL10 axes in cultured normal human mesangial cells treated with polyinosinic-polycytidylic acid (poly IC), a synthetic double-stranded RNA that is sensed by TLR3.	Poly I-C	220-251	toll like receptor 3	Homo sapiens	28-32
28794402-9	2017	DEC1 may serve as an anti-inflammatory factor by negative regulation of MDA5/CXCL10 and RIG-I/CCL5 in human mesangial cells treated with poly IC.	Poly I-C	137-144	deleted in esophageal cancer 1	Homo sapiens	0-4
28794402-9	2017	DEC1 may serve as an anti-inflammatory factor by negative regulation of MDA5/CXCL10 and RIG-I/CCL5 in human mesangial cells treated with poly IC.	Poly I-C	137-144	interferon induced with helicase C domain 1	Homo sapiens	72-76
28794402-9	2017	DEC1 may serve as an anti-inflammatory factor by negative regulation of MDA5/CXCL10 and RIG-I/CCL5 in human mesangial cells treated with poly IC.	Poly I-C	137-144	C-X-C motif chemokine ligand 10	Homo sapiens	77-83
28794402-9	2017	DEC1 may serve as an anti-inflammatory factor by negative regulation of MDA5/CXCL10 and RIG-I/CCL5 in human mesangial cells treated with poly IC.	Poly I-C	137-144	DExD/H-box helicase 58	Homo sapiens	88-93
28794402-9	2017	DEC1 may serve as an anti-inflammatory factor by negative regulation of MDA5/CXCL10 and RIG-I/CCL5 in human mesangial cells treated with poly IC.	Poly I-C	137-144	C-C motif chemokine ligand 5	Homo sapiens	94-98
28222448-6	2017	Here we investigated whether the TLR-3 ligand, polyinosinic:polycytidylic acid (PolyI:C), increased accumulation of one P-gp substrate in the fetus and in the developing fetal brain.	Poly I-C	47-78	toll-like receptor 3	Mus musculus	33-38
28027722-5	2017	In addition, celastrol significantly suppressed poly(I:C)-induced activation of JNK MAPK and STAT1 signaling pathways.	Poly I-C	48-57	mitogen-activated protein kinase 8	Homo sapiens	80-83
28027722-5	2017	In addition, celastrol significantly suppressed poly(I:C)-induced activation of JNK MAPK and STAT1 signaling pathways.	Poly I-C	48-57	signal transducer and activator of transcription 1	Homo sapiens	93-98
28027722-6	2017	Furthermore, celastrol significantly suppressed poly(I:C)-induced activation of the NF-kappaB signaling pathway.	Poly I-C	48-57	nuclear factor kappa B subunit 1	Homo sapiens	84-93
28027722-7	2017	These results suggest that celastrol may exert its regulatory activity by inhibiting poly(I:C)-induced expression of pro-inflammatory mediators by suppressing activation of JNK MAPK-STAT1/NF-kappaB in astrocytes.	Poly I-C	85-94	mitogen-activated protein kinase 8	Homo sapiens	173-176
28027722-7	2017	These results suggest that celastrol may exert its regulatory activity by inhibiting poly(I:C)-induced expression of pro-inflammatory mediators by suppressing activation of JNK MAPK-STAT1/NF-kappaB in astrocytes.	Poly I-C	85-94	signal transducer and activator of transcription 1	Homo sapiens	182-187
28027722-7	2017	These results suggest that celastrol may exert its regulatory activity by inhibiting poly(I:C)-induced expression of pro-inflammatory mediators by suppressing activation of JNK MAPK-STAT1/NF-kappaB in astrocytes.	Poly I-C	85-94	nuclear factor kappa B subunit 1	Homo sapiens	188-197
28222448-6	2017	Here we investigated whether the TLR-3 ligand, polyinosinic:polycytidylic acid (PolyI:C), increased accumulation of one P-gp substrate in the fetus and in the developing fetal brain.	Poly I-C	47-78	phosphoglycolate phosphatase	Mus musculus	120-124
28222448-6	2017	Here we investigated whether the TLR-3 ligand, polyinosinic:polycytidylic acid (PolyI:C), increased accumulation of one P-gp substrate in the fetus and in the developing fetal brain.	Poly I-C	80-87	toll-like receptor 3	Mus musculus	33-38
28222448-6	2017	Here we investigated whether the TLR-3 ligand, polyinosinic:polycytidylic acid (PolyI:C), increased accumulation of one P-gp substrate in the fetus and in the developing fetal brain.	Poly I-C	80-87	phosphoglycolate phosphatase	Mus musculus	120-124
28222448-12	2017	RESULTS: PolyI:C exposure (4h) significantly elevated maternal plasma IL-6 (P&lt;0.001) and increased [3H]digoxin accumulation in the fetal brain (P&lt;0.05).	Poly I-C	9-16	interleukin 6	Mus musculus	70-74
28222448-14	2017	CONCLUSION: Viral infection modeled by PolyI:C causes acute increases in fetal brain accumulation of P-gp substrates and by doing so, may increase fetal brain exposure to xenobiotics and environmental toxins present in the maternal circulation.	Poly I-C	39-46	phosphoglycolate phosphatase	Mus musculus	101-105
29204085-4	2017	In this study we demonstrate that IC or intravenous immunoglobulin (Ig) stimulation of B cells attenuates polyinosinic:polycytidylic acid (poly I:C)-induced CD40 expression; IC, but not Ig, can significantly inhibit poly I:C-induced pro-inflammatory tumour necrosis factor alpha (TNF-alpha) production by B cells.	Poly I-C	139-147	CD40 molecule	Homo sapiens	157-161
29204085-4	2017	In this study we demonstrate that IC or intravenous immunoglobulin (Ig) stimulation of B cells attenuates polyinosinic:polycytidylic acid (poly I:C)-induced CD40 expression; IC, but not Ig, can significantly inhibit poly I:C-induced pro-inflammatory tumour necrosis factor alpha (TNF-alpha) production by B cells.	Poly I-C	139-147	tumor necrosis factor	Homo sapiens	280-289
29204085-4	2017	In this study we demonstrate that IC or intravenous immunoglobulin (Ig) stimulation of B cells attenuates polyinosinic:polycytidylic acid (poly I:C)-induced CD40 expression; IC, but not Ig, can significantly inhibit poly I:C-induced pro-inflammatory tumour necrosis factor alpha (TNF-alpha) production by B cells.	Poly I-C	216-224	CD40 molecule	Homo sapiens	157-161
27815423-4	2016	In this study, we show that zebrafish (Danio rerio) foxo3b, an ortholog of mammalian FOXO3, is induced by polyinosinic-polycytidylic acid stimulation and spring viremia of carp virus (SVCV) infection.	Poly I-C	106-137	forkhead box O3b	Danio rerio	52-58
27999109-7	2017	IFNAR1 deficiency significantly delayed the onset and frequency of diabetes and greatly reduced the intensity of insulitis after poly I:C treatment.	Poly I-C	129-137	interferon alpha and beta receptor subunit 1	Rattus norvegicus	0-6
27820939-5	2017	Activation of PAR-1 enhanced poly I:C induction of IFNbeta and CXCL10 expression in the murine macrophage cell line RAW264.7, bone-marrow derived mouse macrophages (BMM) and mouse splenocytes.	Poly I-C	29-37	coagulation factor II (thrombin) receptor	Mus musculus	14-19
27820939-5	2017	Activation of PAR-1 enhanced poly I:C induction of IFNbeta and CXCL10 expression in the murine macrophage cell line RAW264.7, bone-marrow derived mouse macrophages (BMM) and mouse splenocytes.	Poly I-C	29-37	interferon beta 1, fibroblast	Mus musculus	51-58
27820939-5	2017	Activation of PAR-1 enhanced poly I:C induction of IFNbeta and CXCL10 expression in the murine macrophage cell line RAW264.7, bone-marrow derived mouse macrophages (BMM) and mouse splenocytes.	Poly I-C	29-37	chemokine (C-X-C motif) ligand 10	Mus musculus	63-69
27820939-6	2017	Next, poly I:C was used to induce a type I IFN innate immune response in the spleen and plasma of wild-type (WT) and PAR-1-/- mice.	Poly I-C	6-14	coagulation factor II (thrombin) receptor	Mus musculus	117-122
27820939-7	2017	We found that poly I:C treated PAR-1-/- mice and WT mice given the thrombin inhibitor dabigatran etexilate exhibited significantly less IFNbeta and CXCL10 expression in the spleen and plasma than WT mice.	Poly I-C	14-22	coagulation factor II (thrombin) receptor	Mus musculus	31-36
27820939-7	2017	We found that poly I:C treated PAR-1-/- mice and WT mice given the thrombin inhibitor dabigatran etexilate exhibited significantly less IFNbeta and CXCL10 expression in the spleen and plasma than WT mice.	Poly I-C	14-22	coagulation factor II	Mus musculus	67-75
27820939-7	2017	We found that poly I:C treated PAR-1-/- mice and WT mice given the thrombin inhibitor dabigatran etexilate exhibited significantly less IFNbeta and CXCL10 expression in the spleen and plasma than WT mice.	Poly I-C	14-22	interferon beta 1, fibroblast	Mus musculus	136-143
27820939-7	2017	We found that poly I:C treated PAR-1-/- mice and WT mice given the thrombin inhibitor dabigatran etexilate exhibited significantly less IFNbeta and CXCL10 expression in the spleen and plasma than WT mice.	Poly I-C	14-22	chemokine (C-X-C motif) ligand 10	Mus musculus	148-154
28402971-12	2017	We found that pretreatment of BV2 cells with RANKL for 24 h before the LPS or Poly I:C exposure decreases the expression of inflammatory markers such as inducible nitric oxide synthase and cyclooxygenase.	Poly I-C	78-86	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	45-50
29166644-4	2017	METHODS: We stimulated CYLD-silenced MCs with polyinosinic-polycytidylic acid (poly IC), a synthetic analogue of dsRNA, and studied representative TLR3/IFN-beta pathways (i.e., TLR3/IFN-beta/retinoic acid-inducible gene-I (RIG-I)/CCL5, and TLR3/IFN-beta/melanoma differentiation associated gene 5 (MDA5)/CXCL10 axes) using RT-PCR, western blotting, and ELISA.	Poly I-C	46-77	CYLD lysine 63 deubiquitinase	Homo sapiens	23-27
27815423-4	2016	In this study, we show that zebrafish (Danio rerio) foxo3b, an ortholog of mammalian FOXO3, is induced by polyinosinic-polycytidylic acid stimulation and spring viremia of carp virus (SVCV) infection.	Poly I-C	106-137	forkhead box O3	Homo sapiens	85-90
27815423-5	2016	We found that foxo3b interacted with irf3 and irf7 to inhibit ifr3/irf7 transcriptional activity, thus resulting in suppression of SVCV or polyinosinic-polycytidylic acid-induced IFN activation.	Poly I-C	139-170	forkhead box O3b	Danio rerio	14-20
27815423-5	2016	We found that foxo3b interacted with irf3 and irf7 to inhibit ifr3/irf7 transcriptional activity, thus resulting in suppression of SVCV or polyinosinic-polycytidylic acid-induced IFN activation.	Poly I-C	139-170	interferon regulatory factor 3	Danio rerio	37-41
27815423-5	2016	We found that foxo3b interacted with irf3 and irf7 to inhibit ifr3/irf7 transcriptional activity, thus resulting in suppression of SVCV or polyinosinic-polycytidylic acid-induced IFN activation.	Poly I-C	139-170	interferon regulatory factor 7	Danio rerio	46-50
27815423-5	2016	We found that foxo3b interacted with irf3 and irf7 to inhibit ifr3/irf7 transcriptional activity, thus resulting in suppression of SVCV or polyinosinic-polycytidylic acid-induced IFN activation.	Poly I-C	139-170	interferon regulatory factor 7	Danio rerio	67-71
27955671-5	2016	METHODS: To produce viral-like inflammation, polyinosinic-polycytidylic acid (PIC), a toll-like receptor 3 (TLR3) agonist, was applied to microglial/macrophage cell cultures and to the hippocampus of postnatal day 13 (P13) and postnatal day 74 (P74) rats.	Poly I-C	45-76	toll-like receptor 3	Rattus norvegicus	86-106
27955671-5	2016	METHODS: To produce viral-like inflammation, polyinosinic-polycytidylic acid (PIC), a toll-like receptor 3 (TLR3) agonist, was applied to microglial/macrophage cell cultures and to the hippocampus of postnatal day 13 (P13) and postnatal day 74 (P74) rats.	Poly I-C	45-76	toll-like receptor 3	Rattus norvegicus	108-112
27955671-5	2016	METHODS: To produce viral-like inflammation, polyinosinic-polycytidylic acid (PIC), a toll-like receptor 3 (TLR3) agonist, was applied to microglial/macrophage cell cultures and to the hippocampus of postnatal day 13 (P13) and postnatal day 74 (P74) rats.	Poly I-C	78-81	toll-like receptor 3	Rattus norvegicus	86-106
27955671-5	2016	METHODS: To produce viral-like inflammation, polyinosinic-polycytidylic acid (PIC), a toll-like receptor 3 (TLR3) agonist, was applied to microglial/macrophage cell cultures and to the hippocampus of postnatal day 13 (P13) and postnatal day 74 (P74) rats.	Poly I-C	78-81	toll-like receptor 3	Rattus norvegicus	108-112
27955671-10	2016	PIC administration also led to an increase in interleukin 1beta (IL-1beta) levels in the hippocampus in P14 and P75 rats.	Poly I-C	0-3	interleukin 1 beta	Rattus norvegicus	46-63
27955671-10	2016	PIC administration also led to an increase in interleukin 1beta (IL-1beta) levels in the hippocampus in P14 and P75 rats.	Poly I-C	0-3	interleukin 1 beta	Rattus norvegicus	65-73
27911948-1	2016	Targeting TLR3 through formulations of polyI:C is widely studied as an adjuvant in cancer immunotherapy.	Poly I-C	39-46	toll-like receptor 3	Mus musculus	10-14
27911948-4	2016	Here we found that although DC treatment with polyI:C induced a potent inflammatory response including the production of type I interferon, polyI:C treatment of DCs impaired activation of peptide specific CD8+ T cells mainly due to PD-L1.	Poly I-C	140-147	CD274 antigen	Mus musculus	232-237
27911948-5	2016	Interestingly, we found that PD-L1 trafficking to the cell surface is regulated in two waves in polyI:C-treated DCs.	Poly I-C	96-103	CD274 antigen	Mus musculus	29-34
27911948-6	2016	One induced upon overnight treatment and a second more rapid one, specific to polyI:C treatment, was induced upon CD40 signaling leading to a further increase in surface PD-L1 in DCs.	Poly I-C	78-85	CD40 antigen	Mus musculus	114-118
27911948-6	2016	One induced upon overnight treatment and a second more rapid one, specific to polyI:C treatment, was induced upon CD40 signaling leading to a further increase in surface PD-L1 in DCs.	Poly I-C	78-85	CD274 antigen	Mus musculus	170-175
27911948-7	2016	The polyI:C-induced cell surface PD-L1 reduced the times of contact between DCs and T cells, potentially accounting for limited T cell activation.	Poly I-C	4-11	CD274 antigen	Mus musculus	33-38
28035211-4	2016	Our results demonstrated that among various TLR ligands, MSCs treated with polyinosinic-polycytidylic acid [poly(I:C)], which is a TLR3 ligand, more profoundly induced IDO, which is a therapeutically relevant immunosuppressive factor, without any observable phenotype change in vitro.	Poly I-C	75-106	indoleamine 2,3-dioxygenase 1	Mus musculus	168-171
27793801-6	2016	Interestingly, Runx3 can be synergistically induced by IFNgamma with a synthetic analog of viral dsRNA polyinosinic-polycytidylic acid [poly(I:C)] or tumor necrosis factor-alpha (TNFalpha) through both JAK-STAT1 and NF-kappaB pathways.	Poly I-C	103-134	RUNX family transcription factor 3	Homo sapiens	15-20
27793801-6	2016	Interestingly, Runx3 can be synergistically induced by IFNgamma with a synthetic analog of viral dsRNA polyinosinic-polycytidylic acid [poly(I:C)] or tumor necrosis factor-alpha (TNFalpha) through both JAK-STAT1 and NF-kappaB pathways.	Poly I-C	103-134	interferon gamma	Homo sapiens	55-63
27793801-6	2016	Interestingly, Runx3 can be synergistically induced by IFNgamma with a synthetic analog of viral dsRNA polyinosinic-polycytidylic acid [poly(I:C)] or tumor necrosis factor-alpha (TNFalpha) through both JAK-STAT1 and NF-kappaB pathways.	Poly I-C	103-134	signal transducer and activator of transcription 1	Homo sapiens	206-211
28035211-4	2016	Our results demonstrated that among various TLR ligands, MSCs treated with polyinosinic-polycytidylic acid [poly(I:C)], which is a TLR3 ligand, more profoundly induced IDO, which is a therapeutically relevant immunosuppressive factor, without any observable phenotype change in vitro.	Poly I-C	75-106	toll-like receptor 3	Mus musculus	131-135
28035211-4	2016	Our results demonstrated that among various TLR ligands, MSCs treated with polyinosinic-polycytidylic acid [poly(I:C)], which is a TLR3 ligand, more profoundly induced IDO, which is a therapeutically relevant immunosuppressive factor, without any observable phenotype change in vitro.	Poly I-C	108-117	toll-like receptor 3	Mus musculus	131-135
28035211-4	2016	Our results demonstrated that among various TLR ligands, MSCs treated with polyinosinic-polycytidylic acid [poly(I:C)], which is a TLR3 ligand, more profoundly induced IDO, which is a therapeutically relevant immunosuppressive factor, without any observable phenotype change in vitro.	Poly I-C	108-117	indoleamine 2,3-dioxygenase 1	Mus musculus	168-171
28149670-9	2016	Injection with polyinosinic: polycytidylic acid (poly I:C), a synthetic analogue of double stranded viral RNA that binds Toll-Like Receptor-3 (TLR3), also regulated gene expressions of CCKAR and proinflammatory cytokines, in the different breeds.	Poly I-C	15-47	toll like receptor 3	Gallus gallus	121-141
28149670-9	2016	Injection with polyinosinic: polycytidylic acid (poly I:C), a synthetic analogue of double stranded viral RNA that binds Toll-Like Receptor-3 (TLR3), also regulated gene expressions of CCKAR and proinflammatory cytokines, in the different breeds.	Poly I-C	15-47	toll like receptor 3	Gallus gallus	143-147
28149670-9	2016	Injection with polyinosinic: polycytidylic acid (poly I:C), a synthetic analogue of double stranded viral RNA that binds Toll-Like Receptor-3 (TLR3), also regulated gene expressions of CCKAR and proinflammatory cytokines, in the different breeds.	Poly I-C	15-47	cholecystokinin A receptor	Gallus gallus	185-190
27614570-0	2016	Aripiprazole inhibits polyI:C-induced microglial activation possibly via TRPM7.	Poly I-C	22-29	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	73-78
27614570-6	2016	PolyI:C treatment of murine microglial cells activated the production of TNF-alpha and enhanced the p38 mitogen-activated protein kinase (MAPK) pathway, whereas aripiprazole inhibited these responses.	Poly I-C	0-7	tumor necrosis factor	Mus musculus	73-82
27614570-7	2016	In addition, polyI:C treatment of possible surrogate cells for human microglia markedly increased TNF-alpha mRNA expression in cells from three healthy volunteers.	Poly I-C	13-20	tumor necrosis factor	Homo sapiens	98-107
27614570-10	2016	We demonstrated that transient receptor potential in melastatin 7 (TRPM7) channels contributed to this polyI:C-induced increase in [Ca2+]i.	Poly I-C	103-110	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	21-65
27614570-10	2016	We demonstrated that transient receptor potential in melastatin 7 (TRPM7) channels contributed to this polyI:C-induced increase in [Ca2+]i.	Poly I-C	103-110	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	67-72
27705941-0	2016	MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS).	Poly I-C	33-42	mitochondrial antiviral signaling protein	Homo sapiens	122-163
27705941-0	2016	MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS).	Poly I-C	33-42	mitochondrial antiviral signaling protein	Homo sapiens	165-169
27115203-2	2016	Polyinosinic-polycytidylic acid [poly(I:C)], an analog of viral double-stranded RNA, induces the synthesis of various cytokines, chemokines, adhesion molecules, and matrix metalloproteinases (MMPs) in corneal fibroblasts.	Poly I-C	0-31	matrix metallopeptidase 1	Homo sapiens	192-196
27824119-4	2016	Here we found that the juvenile offspring of poly(I:C)-treated mice showed cognitive deficits, as well as reduced BDNF-TrkB signaling in the prefrontal cortex (PFC).	Poly I-C	45-54	brain derived neurotrophic factor	Mus musculus	114-118
27824119-4	2016	Here we found that the juvenile offspring of poly(I:C)-treated mice showed cognitive deficits, as well as reduced BDNF-TrkB signaling in the prefrontal cortex (PFC).	Poly I-C	45-54	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	119-123
27895399-5	2016	RESULTS: The patients with CD were characterized by a significantly higher monocyte basal expression of TNF-alpha compared with healthy subjects and UC patients, and after stimulation with Pam3CSK4 (ligand of TLR2/1) and MDP-L18 (ligand of NOD2) this difference was maintained, while other microbial stimuli (LPS, ligand of TLR4 and PolyI:C, ligand of TLR3) induced massive activation in CD monocytes as well as in UC and in healthy control cells.	Poly I-C	333-340	tumor necrosis factor	Homo sapiens	104-113
27895399-5	2016	RESULTS: The patients with CD were characterized by a significantly higher monocyte basal expression of TNF-alpha compared with healthy subjects and UC patients, and after stimulation with Pam3CSK4 (ligand of TLR2/1) and MDP-L18 (ligand of NOD2) this difference was maintained, while other microbial stimuli (LPS, ligand of TLR4 and PolyI:C, ligand of TLR3) induced massive activation in CD monocytes as well as in UC and in healthy control cells.	Poly I-C	333-340	toll like receptor 2	Homo sapiens	209-215
27115203-2	2016	Polyinosinic-polycytidylic acid [poly(I:C)], an analog of viral double-stranded RNA, induces the synthesis of various cytokines, chemokines, adhesion molecules, and matrix metalloproteinases (MMPs) in corneal fibroblasts.	Poly I-C	33-42	matrix metallopeptidase 1	Homo sapiens	192-196
27115203-9	2016	It also inhibited the poly(I:C)-induced phosphorylation of c-Jun and the MAPK JNK without affecting that of IkappaB-alpha or the MAPKs ERK and p38.	Poly I-C	22-31	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	59-64
27115203-9	2016	It also inhibited the poly(I:C)-induced phosphorylation of c-Jun and the MAPK JNK without affecting that of IkappaB-alpha or the MAPKs ERK and p38.	Poly I-C	22-31	mitogen-activated protein kinase 14	Homo sapiens	143-146
27577537-4	2016	First, the transcript level of cellular irf6 was upregulated by treatment with poly I:C (a mimic of viral RNAs), indicating IRF6 might be involved in the process of host cell response to viruses.	Poly I-C	79-87	interferon regulatory factor 6	Danio rerio	40-44
27491560-7	2016	Histamine alone did not induce TSLP production in human KC, but pre-incubation with histamine prior to challenge with poly I:C resulted in a significant increase of TSLP production compared to stimulation with poly I:C alone.	Poly I-C	118-126	thymic stromal lymphopoietin	Homo sapiens	165-169
27491560-7	2016	Histamine alone did not induce TSLP production in human KC, but pre-incubation with histamine prior to challenge with poly I:C resulted in a significant increase of TSLP production compared to stimulation with poly I:C alone.	Poly I-C	210-218	thymic stromal lymphopoietin	Homo sapiens	165-169
27449203-0	2016	Hippocampal Abeta expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly I:C administration.	Poly I-C	116-124	amyloid beta precursor protein	Homo sapiens	12-17
27449203-6	2016	Results showed that, although poly I:C-induced Abeta was significantly elevated at all time points examined, poly I:C only disrupted cognition after 14 and 21 days of administration.	Poly I-C	30-38	amyloid beta precursor protein	Homo sapiens	47-52
27577537-4	2016	First, the transcript level of cellular irf6 was upregulated by treatment with poly I:C (a mimic of viral RNAs), indicating IRF6 might be involved in the process of host cell response to viruses.	Poly I-C	79-87	interferon regulatory factor 6	Danio rerio	124-128
27826297-8	2016	In contrast to the effects of LPS treatment, the alarmin high-mobility group protein B1 acts in synergy with polyI:C to promote TSLP and IL33 expression.	Poly I-C	109-116	high mobility group box 1	Homo sapiens	57-87
27826297-8	2016	In contrast to the effects of LPS treatment, the alarmin high-mobility group protein B1 acts in synergy with polyI:C to promote TSLP and IL33 expression.	Poly I-C	109-116	thymic stromal lymphopoietin	Homo sapiens	128-132
27826297-8	2016	In contrast to the effects of LPS treatment, the alarmin high-mobility group protein B1 acts in synergy with polyI:C to promote TSLP and IL33 expression.	Poly I-C	109-116	interleukin 33	Homo sapiens	137-141
27724984-10	2016	Furthermore, MSCs treated with poly(I:C) reduced the differentiation/activation of proinflammatory lymphocytes, Th1 and Th17.	Poly I-C	31-40	negative elongation factor complex member C/D, Th1l	Mus musculus	112-115
27601297-6	2016	Moreover, Ec-MKK7 was universally expressed in all examined tissues and showed expression modulation to challenges of lipopolysacchride (LPS), Singapore grouper iridovirus (SGIV) and polyriboinosinic polyribocytidylic acid (poly I:C) in vivo.	Poly I-C	183-222	mitogen-activated protein kinase kinase 7	Homo sapiens	13-17
27677339-10	2016	In addition, pre-treatment with a P2Y2 receptor siRNA significantly suppressed the poly(I:C)-potentiated EGFR ligands and MUC5AC release.	Poly I-C	83-92	epidermal growth factor receptor	Homo sapiens	105-109
27311810-0	2016	Polyinosinic-polycytidylic acid inhibits the differentiation of mouse preadipocytes through pattern recognition receptor-mediated secretion of tumor necrosis factor-alpha.	Poly I-C	0-31	tumor necrosis factor	Mus musculus	143-170
27311810-2	2016	Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRRs) such as Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	0-31	toll-like receptor 3	Mus musculus	229-249
27311810-2	2016	Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRRs) such as Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	0-31	toll-like receptor 3	Mus musculus	251-255
27311810-2	2016	Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRRs) such as Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	0-31	DEAD/H box helicase 58	Mus musculus	258-288
27311810-2	2016	Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRRs) such as Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	0-31	DEAD/H box helicase 58	Mus musculus	290-295
27311810-2	2016	Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRRs) such as Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	0-31	interferon induced with helicase C domain 1	Mus musculus	301-343
27311810-2	2016	Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRRs) such as Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).	Poly I-C	0-31	interferon induced with helicase C domain 1	Mus musculus	345-349
27311810-7	2016	The effect of exogenously added poly(I:C) on inhibition of differentiation was significantly diminished in the preadipocytes of TLR3 knockout mice.	Poly I-C	32-41	toll-like receptor 3	Mus musculus	128-132
27311810-10	2016	The effect of poly(I:C) stimulation, either through endogenous transfection or exogenous addition, on inhibition of differentiation was significantly diminished in the preadipocytes of TNF-alpha knockout mice.	Poly I-C	14-23	tumor necrosis factor	Mus musculus	185-194
27311810-11	2016	These results confirmed the evidence that poly(I:C) inhibited the differentiation of mouse preadipocytes through PRR-mediated secretion of TNF-alpha.	Poly I-C	42-51	tumor necrosis factor	Mus musculus	139-148
27999750-2	2016	We previously described the ability of aerosolized CpG-ODN combined with Poly(I:C) (TLR9 and TLR3 agonists, respectively) to promote antitumor immunity in a B16 melanoma lung metastasis model.	Poly I-C	73-82	toll like receptor 9	Homo sapiens	84-88
27999750-2	2016	We previously described the ability of aerosolized CpG-ODN combined with Poly(I:C) (TLR9 and TLR3 agonists, respectively) to promote antitumor immunity in a B16 melanoma lung metastasis model.	Poly I-C	73-82	toll like receptor 3	Homo sapiens	93-97
27677339-10	2016	In addition, pre-treatment with a P2Y2 receptor siRNA significantly suppressed the poly(I:C)-potentiated EGFR ligands and MUC5AC release.	Poly I-C	83-92	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	122-128
27677339-11	2016	After poly(I:C) stimulation, the expression of MUC5AC in the differentiated cells from COPD patients was significantly higher than those from healthy subjects and the values of MUC5AC expression were inversely related with forced expiratory volume in 1 s (FEV1) % predicted.	Poly I-C	6-14	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	47-53
27677339-11	2016	After poly(I:C) stimulation, the expression of MUC5AC in the differentiated cells from COPD patients was significantly higher than those from healthy subjects and the values of MUC5AC expression were inversely related with forced expiratory volume in 1 s (FEV1) % predicted.	Poly I-C	6-14	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	177-183
27677339-12	2016	The inhibitory effects of CBX and suramin on poly(I:C)-potentiated MUC5AC expression were confirmed in differentiated airway epithelium from COPD patients.	Poly I-C	45-54	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	67-73
27645024-4	2016	The complete understanding of transcriptional regulation of FAM26F is in its infancy however it is up regulated by various stimulants such as polyI:C, LPS, INF gamma and TNF alpha, and via various proposed pathways including TLR3, TLR4 IFN-beta and Dectin-1.	Poly I-C	142-149	calcium homeostasis modulator family member 6	Homo sapiens	60-66
27317300-8	2016	After injection of rotenone or Poly (I:C) into the rat striatum, we found that expression of the CB2 receptor was significantly elevated in both models, and that this increase correlated significantly with an increase in microglial activation in the rotenone model.	Poly I-C	31-41	cannabinoid receptor 2	Rattus norvegicus	97-100
27645024-4	2016	The complete understanding of transcriptional regulation of FAM26F is in its infancy however it is up regulated by various stimulants such as polyI:C, LPS, INF gamma and TNF alpha, and via various proposed pathways including TLR3, TLR4 IFN-beta and Dectin-1.	Poly I-C	142-149	toll like receptor 3	Homo sapiens	225-229
27645024-4	2016	The complete understanding of transcriptional regulation of FAM26F is in its infancy however it is up regulated by various stimulants such as polyI:C, LPS, INF gamma and TNF alpha, and via various proposed pathways including TLR3, TLR4 IFN-beta and Dectin-1.	Poly I-C	142-149	toll like receptor 4	Homo sapiens	231-235
27645024-4	2016	The complete understanding of transcriptional regulation of FAM26F is in its infancy however it is up regulated by various stimulants such as polyI:C, LPS, INF gamma and TNF alpha, and via various proposed pathways including TLR3, TLR4 IFN-beta and Dectin-1.	Poly I-C	142-149	interferon beta 1	Homo sapiens	236-244
27645024-4	2016	The complete understanding of transcriptional regulation of FAM26F is in its infancy however it is up regulated by various stimulants such as polyI:C, LPS, INF gamma and TNF alpha, and via various proposed pathways including TLR3, TLR4 IFN-beta and Dectin-1.	Poly I-C	142-149	C-type lectin domain containing 7A	Homo sapiens	249-257
27321649-8	2016	RESULTS: The TLR3 ligand polyinosinic-polycytidylic acid (poly I:C) specifically induced chemokine generation and apoptosis, while other TLR ligands including those for TLR5, 7/8, and 9 had no effect.	Poly I-C	25-56	toll like receptor 3	Homo sapiens	13-17
27321649-8	2016	RESULTS: The TLR3 ligand polyinosinic-polycytidylic acid (poly I:C) specifically induced chemokine generation and apoptosis, while other TLR ligands including those for TLR5, 7/8, and 9 had no effect.	Poly I-C	58-66	toll like receptor 3	Homo sapiens	13-17
27321649-8	2016	RESULTS: The TLR3 ligand polyinosinic-polycytidylic acid (poly I:C) specifically induced chemokine generation and apoptosis, while other TLR ligands including those for TLR5, 7/8, and 9 had no effect.	Poly I-C	58-66	toll like receptor 5	Homo sapiens	169-173
27321649-11	2016	CONCLUSIONS: Previous findings indicating that viruses induced caspase-dependent death and upregulated Fas expression were reproduced by poly I:C, suggesting the central role of dsRNA/TLR3 in virus-induced apoptosis.	Poly I-C	137-145	toll like receptor 3	Homo sapiens	184-188
27412245-5	2016	STUDY DESIGN, SIZE, DURATION: Poly I:C was used as a TLR3 specific ligand and endometrial cells were either treated or not with Poly I:C (treated versus control) in vitro.	Poly I-C	30-38	toll like receptor 3	Homo sapiens	53-57
27603520-3	2016	The long double-stranded RNA (dsRNA) viral mimic, polyinosinic polycytidylic acid (polyIC, PIC) potently stimulates DCs to focus Th1 responses, triggers direct antiviral activity in vitro, and boosts anti-HIV responses in vivo.	Poly I-C	50-81	negative elongation factor complex member C/D	Homo sapiens	129-132
27412245-16	2016	MAIN RESULTS AND THE ROLE OF CHANCE: Our results showed that addition of polyinosinic:polycytidylic acid (Poly I:C) to RL95-2 cells significantly increased the production of IL-1RA (P &lt; 0.05).	Poly I-C	106-114	interleukin 1 receptor antagonist	Homo sapiens	174-180
27317300-9	2016	Interestingly, the increase in CB2 receptor expression in the inflammation-driven Poly (I:C) model was significantly more pronounced than that in the neurotoxic rotenone model.	Poly I-C	82-92	cannabinoid receptor 2	Rattus norvegicus	31-43
27421476-4	2016	The results showed that aberrantly elevated miR-148a in bone marrow-derived TADC (BM-TADC) abolished polyinosinic-polycytidylic acid (poly I:C) or LPS-induced dendritic cell maturation through directly suppressing DNMT1 gene, which consequently led to the hypomethylation and upregulation of SOCS1, the suppressor of TLR signaling.	Poly I-C	101-132	microRNA 148a	Homo sapiens	44-52
27416475-2	2016	Exposure to AF-SWCNT during NK activation in vitro by interleukin (IL)-2, and in vivo by Poly(I:C) significantly lowered cytotoxic activity generated against YAC-1 tumor cells.	Poly I-C	89-97	ADP-ribosyltransferase 1	Mus musculus	158-163
27529176-7	2016	BDCA3+ DCs from patient blood are not more mature at steady state, but display an impaired capacity to mature and to produce interferon-lambda upon polyI:C stimulation.	Poly I-C	148-155	thrombomodulin	Homo sapiens	0-5
29263853-8	2016	This works further highlights that TLR3/MDA5 agonists such as Poly(I:C) may be valuable adjuvants for ID vaccination against sexually transmitted diseases.	Poly I-C	62-71	toll like receptor 3	Homo sapiens	35-39
29263853-8	2016	This works further highlights that TLR3/MDA5 agonists such as Poly(I:C) may be valuable adjuvants for ID vaccination against sexually transmitted diseases.	Poly I-C	62-71	interferon induced with helicase C domain 1	Homo sapiens	40-44
27037842-3	2016	Specifically, we show that vaccination with a recombinant CEA IgV-like N domain, formulated with the TLR3 ligand poly I:C, elicits a CEA-specific TH 9 response, wherein IL-9 secreting TH cells act in concert with CEA N domain-specific antibodies as well as activated mast cells in preventing tumor cell engraftment.	Poly I-C	113-121	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	58-61
27037842-3	2016	Specifically, we show that vaccination with a recombinant CEA IgV-like N domain, formulated with the TLR3 ligand poly I:C, elicits a CEA-specific TH 9 response, wherein IL-9 secreting TH cells act in concert with CEA N domain-specific antibodies as well as activated mast cells in preventing tumor cell engraftment.	Poly I-C	113-121	toll like receptor 3	Homo sapiens	101-105
27037842-3	2016	Specifically, we show that vaccination with a recombinant CEA IgV-like N domain, formulated with the TLR3 ligand poly I:C, elicits a CEA-specific TH 9 response, wherein IL-9 secreting TH cells act in concert with CEA N domain-specific antibodies as well as activated mast cells in preventing tumor cell engraftment.	Poly I-C	113-121	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	133-136
27037842-3	2016	Specifically, we show that vaccination with a recombinant CEA IgV-like N domain, formulated with the TLR3 ligand poly I:C, elicits a CEA-specific TH 9 response, wherein IL-9 secreting TH cells act in concert with CEA N domain-specific antibodies as well as activated mast cells in preventing tumor cell engraftment.	Poly I-C	113-121	interleukin 9	Homo sapiens	169-173
27037842-3	2016	Specifically, we show that vaccination with a recombinant CEA IgV-like N domain, formulated with the TLR3 ligand poly I:C, elicits a CEA-specific TH 9 response, wherein IL-9 secreting TH cells act in concert with CEA N domain-specific antibodies as well as activated mast cells in preventing tumor cell engraftment.	Poly I-C	113-121	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	133-136
27198486-6	2016	Similarly, in human monocyte-derived DCs poly(I:C) induces both cell death and the expression of ApoLs, principally ApoL3.	Poly I-C	41-50	apolipoprotein L3	Homo sapiens	116-121
27129189-4	2016	In the present study, we demonstrate for the first time that 1,8-cineole potentiates poly(I:C)-induced activity of the antiviral transcription factor interferon regulatory factor 3 (IRF3), while simultaneously reducing proinflammatory nuclear factor (NF)-kappaB activity in human cell lines, inferior turbinate stem cells (ITSCs) and in ex vivo cultivated human nasal mucosa.	Poly I-C	85-94	interferon regulatory factor 3	Homo sapiens	150-180
27129189-4	2016	In the present study, we demonstrate for the first time that 1,8-cineole potentiates poly(I:C)-induced activity of the antiviral transcription factor interferon regulatory factor 3 (IRF3), while simultaneously reducing proinflammatory nuclear factor (NF)-kappaB activity in human cell lines, inferior turbinate stem cells (ITSCs) and in ex vivo cultivated human nasal mucosa.	Poly I-C	85-94	interferon regulatory factor 3	Homo sapiens	182-186
27129189-4	2016	In the present study, we demonstrate for the first time that 1,8-cineole potentiates poly(I:C)-induced activity of the antiviral transcription factor interferon regulatory factor 3 (IRF3), while simultaneously reducing proinflammatory nuclear factor (NF)-kappaB activity in human cell lines, inferior turbinate stem cells (ITSCs) and in ex vivo cultivated human nasal mucosa.	Poly I-C	85-94	nuclear factor kappa B subunit 1	Homo sapiens	235-261
27129189-5	2016	Co-treatment of cell lines with poly(I:C) and 1,8-cineole resulted in significantly increased IRF3 reporter gene activity compared with poly(I:C) alone, whereas NF-kappaB activity was reduced.	Poly I-C	32-40	interferon regulatory factor 3	Homo sapiens	94-98
27504984-0	2016	Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5.	Poly I-C	0-8	claudin 5	Homo sapiens	104-113
27504984-2	2016	Here, we investigated the effect of the Toll-like receptor 3 (TLR3) ligand polyinosinic-polycytidylic acid [Poly(I:C)], a synthetic analog of viral double-stranded RNA (dsRNA) commonly used to simulate viral infections, on the barrier function and tight junction integrity of primary human lung microvascular endothelial cells.	Poly I-C	75-106	toll like receptor 3	Homo sapiens	40-60
27504984-2	2016	Here, we investigated the effect of the Toll-like receptor 3 (TLR3) ligand polyinosinic-polycytidylic acid [Poly(I:C)], a synthetic analog of viral double-stranded RNA (dsRNA) commonly used to simulate viral infections, on the barrier function and tight junction integrity of primary human lung microvascular endothelial cells.	Poly I-C	75-106	toll like receptor 3	Homo sapiens	62-66
27504984-4	2016	Poly(I:C) increased endothelial monolayer permeability with a corresponding dose- and time-dependent decrease in the expression of claudin-5, a transmembrane tight junction protein and reduction of CLDN5 mRNA levels.	Poly I-C	0-8	claudin 5	Homo sapiens	131-140
27504984-4	2016	Poly(I:C) increased endothelial monolayer permeability with a corresponding dose- and time-dependent decrease in the expression of claudin-5, a transmembrane tight junction protein and reduction of CLDN5 mRNA levels.	Poly I-C	0-8	claudin 5	Homo sapiens	198-203
27260485-0	2016	Poly (I:C)-DOTAP cationic nanoliposome containing multi-epitope HER2-derived peptide promotes vaccine-elicited anti-tumor immunity in a murine model.	Poly I-C	0-10	erb-b2 receptor tyrosine kinase 2	Mus musculus	64-68
27260485-8	2016	Flow cytometry analysis revealed that Lip-P5+PIC formulation induced the highest level of IFN-gamma in CD8(+) lymphocytes.	Poly I-C	45-48	interferon gamma	Mus musculus	90-99
27327127-6	2016	The MDA5 promoter activity was extremely low under basal condition, but was dramatically increased when cells were stimulated with polyinosinic: polycytidylic acid (poly I:C), interferon beta (IFN-beta) or Infectious Bursal Disease Virus (IBDV).	Poly I-C	131-163	interferon induced with helicase C domain 1	Gallus gallus	4-8
27438481-7	2016	Moreover, the in vivo T cell defects in RIG-I deficient mice can be overcome by the activation of MDA5 -MAVS via poly I:C treatment.	Poly I-C	113-121	mitochondrial antiviral signaling protein	Mus musculus	104-108
27030513-4	2016	We show that in vitro-generated dsRNAs, dsRNAs purified from virus-infected plants and the dsRNA analog polyinosinic-polycytidylic acid (poly(I:C)) induce typical PTI responses dependent on the co-receptor SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 1 (SERK1), but independent of dicer-like (DCL) proteins in Arabidopsis.	Poly I-C	104-135	somatic embryogenesis receptor-like kinase 1	Arabidopsis thaliana	206-250
27030513-4	2016	We show that in vitro-generated dsRNAs, dsRNAs purified from virus-infected plants and the dsRNA analog polyinosinic-polycytidylic acid (poly(I:C)) induce typical PTI responses dependent on the co-receptor SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 1 (SERK1), but independent of dicer-like (DCL) proteins in Arabidopsis.	Poly I-C	104-135	somatic embryogenesis receptor-like kinase 1	Arabidopsis thaliana	252-257
27438481-7	2016	Moreover, the in vivo T cell defects in RIG-I deficient mice can be overcome by the activation of MDA5 -MAVS via poly I:C treatment.	Poly I-C	113-121	interferon induced with helicase C domain 1	Mus musculus	98-102
27387278-6	2016	HMGB1 neutralizing mAb treatment in poly(I:C)-challenged recipient mice alleviated pulmonary histopathological changes, neutrophil infiltration and inflammatory cytokine release, but unaffected the level of IFN-beta, the distribution of CD11b(+)CD27(+)/CD11b(+)CD27(-) NK cell subsets, and CD8(+) T cell responses.	Poly I-C	36-45	high mobility group box 1	Mus musculus	0-5
27387278-6	2016	HMGB1 neutralizing mAb treatment in poly(I:C)-challenged recipient mice alleviated pulmonary histopathological changes, neutrophil infiltration and inflammatory cytokine release, but unaffected the level of IFN-beta, the distribution of CD11b(+)CD27(+)/CD11b(+)CD27(-) NK cell subsets, and CD8(+) T cell responses.	Poly I-C	36-45	integrin subunit alpha M	Homo sapiens	253-258
27387278-6	2016	HMGB1 neutralizing mAb treatment in poly(I:C)-challenged recipient mice alleviated pulmonary histopathological changes, neutrophil infiltration and inflammatory cytokine release, but unaffected the level of IFN-beta, the distribution of CD11b(+)CD27(+)/CD11b(+)CD27(-) NK cell subsets, and CD8(+) T cell responses.	Poly I-C	36-45	CD8a molecule	Homo sapiens	290-293
27259252-4	2016	In this model, poly I:C contributed to the recruitment of CD11b+Ly6G+ neutrophils to the TME, and co-injection of poly I:C and HVJ-E increased CD11b+Ly6G+FAS+ TAN in the TME.	Poly I-C	114-122	integrin alpha M	Mus musculus	58-63
27259252-4	2016	In this model, poly I:C contributed to the recruitment of CD11b+Ly6G+ neutrophils to the TME, and co-injection of poly I:C and HVJ-E increased CD11b+Ly6G+FAS+ TAN in the TME.	Poly I-C	15-23	integrin alpha M	Mus musculus	58-63
27259252-4	2016	In this model, poly I:C contributed to the recruitment of CD11b+Ly6G+ neutrophils to the TME, and co-injection of poly I:C and HVJ-E increased CD11b+Ly6G+FAS+ TAN in the TME.	Poly I-C	114-122	lymphocyte antigen 6 complex, locus G	Mus musculus	64-68
27259252-4	2016	In this model, poly I:C contributed to the recruitment of CD11b+Ly6G+ neutrophils to the TME, and co-injection of poly I:C and HVJ-E increased CD11b+Ly6G+FAS+ TAN in the TME.	Poly I-C	15-23	lymphocyte antigen 6 complex, locus G	Mus musculus	64-68
27259252-4	2016	In this model, poly I:C contributed to the recruitment of CD11b+Ly6G+ neutrophils to the TME, and co-injection of poly I:C and HVJ-E increased CD11b+Ly6G+FAS+ TAN in the TME.	Poly I-C	114-122	integrin alpha M	Mus musculus	143-148
27259252-4	2016	In this model, poly I:C contributed to the recruitment of CD11b+Ly6G+ neutrophils to the TME, and co-injection of poly I:C and HVJ-E increased CD11b+Ly6G+FAS+ TAN in the TME.	Poly I-C	114-122	lymphocyte antigen 6 complex, locus G	Mus musculus	149-153
27259252-6	2016	We revealed that C-X-C motif chemokine ligand 2 (CXCL2) is produced in the TME by poly I:C, but HVJ-E enhanced neutrophil infiltration of the TME does not occur.	Poly I-C	82-90	chemokine (C-X-C motif) ligand 2	Mus musculus	17-47
27259252-6	2016	We revealed that C-X-C motif chemokine ligand 2 (CXCL2) is produced in the TME by poly I:C, but HVJ-E enhanced neutrophil infiltration of the TME does not occur.	Poly I-C	82-90	chemokine (C-X-C motif) ligand 2	Mus musculus	49-54
27210890-7	2016	KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1beta, IL-6, IL-8, CCL20, and TNF-alpha, and downregulated NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	41-50	interleukin 1 beta	Homo sapiens	106-114
27347031-5	2016	Production of nitric oxide (NO), various cytokines, as well as calcium release and the mRNA expression of signal transducer and activator of transcription 1 (STAT1) in dsRNA polyinosinic-polycytidylic acid (PIC)-induced RAW 264.7 mouse macrophages were evaluated.	Poly I-C	174-205	signal transducer and activator of transcription 1	Mus musculus	106-156
27347031-5	2016	Production of nitric oxide (NO), various cytokines, as well as calcium release and the mRNA expression of signal transducer and activator of transcription 1 (STAT1) in dsRNA polyinosinic-polycytidylic acid (PIC)-induced RAW 264.7 mouse macrophages were evaluated.	Poly I-C	174-205	signal transducer and activator of transcription 1	Mus musculus	158-163
27347031-5	2016	Production of nitric oxide (NO), various cytokines, as well as calcium release and the mRNA expression of signal transducer and activator of transcription 1 (STAT1) in dsRNA polyinosinic-polycytidylic acid (PIC)-induced RAW 264.7 mouse macrophages were evaluated.	Poly I-C	207-210	signal transducer and activator of transcription 1	Mus musculus	106-156
27347031-5	2016	Production of nitric oxide (NO), various cytokines, as well as calcium release and the mRNA expression of signal transducer and activator of transcription 1 (STAT1) in dsRNA polyinosinic-polycytidylic acid (PIC)-induced RAW 264.7 mouse macrophages were evaluated.	Poly I-C	207-210	signal transducer and activator of transcription 1	Mus musculus	158-163
27206770-5	2016	Ablation of DrSIGIRR by lentivirus-delivered small interfering RNA in the liver significantly enhanced hepatic inflammation in response to polyinosinic-polycytidylic acid [poly(I:C)] stimulation, as shown by the upregulation of inflammatory cytokines and increased histological disorders.	Poly I-C	139-170	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	Danio rerio	12-20
27206770-6	2016	In contrast, depletion of TIR domain-containing adaptor inducing IFN-beta (TRIF) or administration of TRIF signaling inhibitor extremely abrogated the poly(I:C)-induced hepatic inflammation.	Poly I-C	151-160	toll-like receptor adaptor molecule 1	Danio rerio	26-73
27206770-6	2016	In contrast, depletion of TIR domain-containing adaptor inducing IFN-beta (TRIF) or administration of TRIF signaling inhibitor extremely abrogated the poly(I:C)-induced hepatic inflammation.	Poly I-C	151-160	toll-like receptor adaptor molecule 1	Danio rerio	75-79
27206770-6	2016	In contrast, depletion of TIR domain-containing adaptor inducing IFN-beta (TRIF) or administration of TRIF signaling inhibitor extremely abrogated the poly(I:C)-induced hepatic inflammation.	Poly I-C	151-160	toll-like receptor adaptor molecule 1	Danio rerio	102-106
27206770-7	2016	Aided by the zebrafish embryo model, overexpression of DrSIGIRR in vivo significantly inhibited the poly(I:C)- and TRIF-induced NF-kappaB activations; however, knockdown of DrSIGIRR promoted such activations.	Poly I-C	100-109	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	Danio rerio	55-63
27206770-7	2016	Aided by the zebrafish embryo model, overexpression of DrSIGIRR in vivo significantly inhibited the poly(I:C)- and TRIF-induced NF-kappaB activations; however, knockdown of DrSIGIRR promoted such activations.	Poly I-C	100-109	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	Danio rerio	173-181
27183205-5	2016	In this study, we attempted to dissect the molecular mechanism underlying TLR3-agonist polyinosinic-polycytidylic acid [poly(I:C)] treatment in NB in vivo.	Poly I-C	87-118	toll like receptor 3	Homo sapiens	74-78
27183205-5	2016	In this study, we attempted to dissect the molecular mechanism underlying TLR3-agonist polyinosinic-polycytidylic acid [poly(I:C)] treatment in NB in vivo.	Poly I-C	120-129	toll like receptor 3	Homo sapiens	74-78
27183205-9	2016	Poly(I:C) inducing activation of TLR3/IRF3-mediated innate immunity associated with downregulation of c-Myc can be found in MYCN-non-amplified SK-N-AS cells, but not in MYCN-amplified BE(2)-M17 cells.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	33-37
27183205-9	2016	Poly(I:C) inducing activation of TLR3/IRF3-mediated innate immunity associated with downregulation of c-Myc can be found in MYCN-non-amplified SK-N-AS cells, but not in MYCN-amplified BE(2)-M17 cells.	Poly I-C	0-8	interferon regulatory factor 3	Homo sapiens	38-42
27183205-9	2016	Poly(I:C) inducing activation of TLR3/IRF3-mediated innate immunity associated with downregulation of c-Myc can be found in MYCN-non-amplified SK-N-AS cells, but not in MYCN-amplified BE(2)-M17 cells.	Poly I-C	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	102-107
27183205-9	2016	Poly(I:C) inducing activation of TLR3/IRF3-mediated innate immunity associated with downregulation of c-Myc can be found in MYCN-non-amplified SK-N-AS cells, but not in MYCN-amplified BE(2)-M17 cells.	Poly I-C	0-8	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	124-128
27183205-13	2016	Thus, our results suggest that c-Myc overexpression may increase sensitivity to poly(I:C)-induced tumor growth arrest and ROS-mediated apoptosis in NB.	Poly I-C	80-89	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	31-36
27379082-5	2016	Polyinosinic-polycytidylic acid (poly I:C), flagellin, and synthetic lipoprotein (FSL-1) significantly induced expression of IL-36gamma in a dose-dependent manner, and appeared to be TLR-dependent.	Poly I-C	0-31	follistatin like 1	Homo sapiens	82-87
27210890-9	2016	Furthermore, RA markedly inhibited poly(I:C)-induced NLRP3 and ASC expression.	Poly I-C	35-44	NLR family pyrin domain containing 3	Homo sapiens	53-58
27210890-9	2016	Furthermore, RA markedly inhibited poly(I:C)-induced NLRP3 and ASC expression.	Poly I-C	35-44	PYD and CARD domain containing	Homo sapiens	63-66
27216537-0	2016	Effects of prenatal Poly I:C exposure on global histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity in the mouse brain.	Poly I-C	20-28	DNA methyltransferase (cytosine-5) 1	Mus musculus	79-100
27216537-0	2016	Effects of prenatal Poly I:C exposure on global histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity in the mouse brain.	Poly I-C	20-28	DNA methyltransferase (cytosine-5) 1	Mus musculus	102-106
27216537-1	2016	The aim of our study was to investigate the brain-specific epigenetic effects on global enzymatic histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity after prenatal exposure to maternal immune challenge by polyinosinic:polycytidylic acid (Poly I:C) at gestational day (GD) 17 in C57BL/6JRccHsd mouse offspring.	Poly I-C	223-254	DNA methyltransferase (cytosine-5) 1	Mus musculus	129-150
27216537-1	2016	The aim of our study was to investigate the brain-specific epigenetic effects on global enzymatic histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity after prenatal exposure to maternal immune challenge by polyinosinic:polycytidylic acid (Poly I:C) at gestational day (GD) 17 in C57BL/6JRccHsd mouse offspring.	Poly I-C	223-254	DNA methyltransferase (cytosine-5) 1	Mus musculus	152-156
27210890-7	2016	KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1beta, IL-6, IL-8, CCL20, and TNF-alpha, and downregulated NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	41-50	interleukin 6	Homo sapiens	116-120
27210890-7	2016	KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1beta, IL-6, IL-8, CCL20, and TNF-alpha, and downregulated NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
27210890-7	2016	KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1beta, IL-6, IL-8, CCL20, and TNF-alpha, and downregulated NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	41-50	C-C motif chemokine ligand 20	Homo sapiens	128-133
27210890-7	2016	KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1beta, IL-6, IL-8, CCL20, and TNF-alpha, and downregulated NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	41-50	tumor necrosis factor	Homo sapiens	139-148
27210890-8	2016	In addition, RA significantly inhibited poly(I:C)-induced inflammasome activation, in terms of secretion of active form of IL-1beta and caspase-1.	Poly I-C	40-49	interleukin 1 beta	Homo sapiens	123-131
27210890-8	2016	In addition, RA significantly inhibited poly(I:C)-induced inflammasome activation, in terms of secretion of active form of IL-1beta and caspase-1.	Poly I-C	40-49	caspase 1	Homo sapiens	136-145
27141827-7	2016	In bone marrow-derived dendritic cells (BMDCs) and macrophages (BMDMs), and splenic DC subsets, polyinosinic-polycytidylic acid (polyI:C) followed by type I interferon (IFN) production induced Trem4 and Treml6 whereas polyI:C or other TLR agonists failed to induce the expression of Trem5.	Poly I-C	96-127	triggering receptor expressed on myeloid cells 4	Mus musculus	193-198
27622060-10	2016	Subcutaneous administration of Poly(I:C) and adoptive transfer of wild-type CD8alpha(+) DC largely recovered antitumor response in those Batf3 (-/-) mice.	Poly I-C	31-39	basic leucine zipper transcription factor, ATF-like 3	Mus musculus	137-142
26776071-6	2016	Prenatal polyI:C treatment resulted in increased dopamine sensitivity and dopamine D2 receptor expression in adult offspring which was not reversed by environmental enrichment.	Poly I-C	9-16	dopamine receptor D2	Mus musculus	74-94
27034235-9	2016	Monocytes activated by the supernatant of cancer cells previously exposed to poly(I:C) recruited significantly more Th1 cells than monocytes exposed to control supernatants.	Poly I-C	77-85	negative elongation factor complex member C/D	Homo sapiens	116-119
26635116-4	2016	Polyinosinic-polycytidylic acid (poly(I:C)) and interferon beta (IFN-beta) stimulated the secretion of MMP-13 from SAECs by more than several hundred-fold.	Poly I-C	0-31	matrix metallopeptidase 13	Homo sapiens	103-109
27141827-7	2016	In bone marrow-derived dendritic cells (BMDCs) and macrophages (BMDMs), and splenic DC subsets, polyinosinic-polycytidylic acid (polyI:C) followed by type I interferon (IFN) production induced Trem4 and Treml6 whereas polyI:C or other TLR agonists failed to induce the expression of Trem5.	Poly I-C	96-127	RIKEN cDNA B430306N03 gene	Mus musculus	203-209
27141827-7	2016	In bone marrow-derived dendritic cells (BMDCs) and macrophages (BMDMs), and splenic DC subsets, polyinosinic-polycytidylic acid (polyI:C) followed by type I interferon (IFN) production induced Trem4 and Treml6 whereas polyI:C or other TLR agonists failed to induce the expression of Trem5.	Poly I-C	96-127	triggering receptor expressed on myeloid cells 5	Mus musculus	283-288
27141827-8	2016	PolyI:C induced Treml6 and Trem4 more efficiently in BMDMs than BMDCs.	Poly I-C	0-7	RIKEN cDNA B430306N03 gene	Mus musculus	16-22
27141827-8	2016	PolyI:C induced Treml6 and Trem4 more efficiently in BMDMs than BMDCs.	Poly I-C	0-7	triggering receptor expressed on myeloid cells 4	Mus musculus	27-32
27096321-6	2016	Thus, the paucity of activated CD103(+) DCs in tumors limits checkpoint-blockade efficacy and combined FLT3L and poly I:C therapy can enhance tumor responses to checkpoint and BRAF blockade.	Poly I-C	113-121	Braf transforming gene	Mus musculus	176-180
26931406-0	2016	Live imaging of transforming growth factor-beta activated kinase 1 activation in Lewis lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyinosinic:polycytidylic acid.	Poly I-C	159-190	mitogen-activated protein kinase kinase kinase 7	Mus musculus	16-66
26931406-2	2016	Here, we live-imaged robust TAK1 activation in Lewis lung carcinoma 3LL cells implanted into the s.c. tissue of syngeneic C57BL/6 mice and treated with polyinosinic:polycytidylic acid (PolyI:C).	Poly I-C	152-183	mitogen-activated protein kinase kinase kinase 7	Mus musculus	28-32
26931406-2	2016	Here, we live-imaged robust TAK1 activation in Lewis lung carcinoma 3LL cells implanted into the s.c. tissue of syngeneic C57BL/6 mice and treated with polyinosinic:polycytidylic acid (PolyI:C).	Poly I-C	185-192	mitogen-activated protein kinase kinase kinase 7	Mus musculus	28-32
26931406-6	2016	Activity of TAK1 in 3LL cells was markedly increased by PolyI:C in the presence of macrophages.	Poly I-C	56-63	mitogen-activated protein kinase kinase kinase 7	Mus musculus	12-16
26931406-9	2016	Injection of PolyI:C, which is known to induce regression of the implanted tumors, induced marked and homogenous TAK1 activation within the tumor tissues.	Poly I-C	13-20	mitogen-activated protein kinase kinase kinase 7	Mus musculus	113-117
26757165-13	2016	MEASUREMENTS AND MAIN RESULTS: The agonists for Toll-like receptor 4 (lipopolysaccharide) or Toll-like receptor 3 (polyinosinic-polycytidylic acid) induced a marked increase in complement factor B expression in human proximal tubular cells and mouse tubular epithelial cells both at gene and protein levels.	Poly I-C	115-146	complement factor B	Homo sapiens	177-196
26757165-16	2016	Lipopolysaccharide/polyinosinic-polycytidylic acid-induced complement factor B up-regulation was blocked by Bay 11-7082, a potent inhibitor of nuclear factor-kappaB signaling, and in mouse tubular epithelial cells deficient in p50 subunit of nuclear factor-kappaB.	Poly I-C	19-50	complement factor B	Mus musculus	59-78
27066702-5	2016	The PKR inhibition was sustained until 10h post infection in the presence of polyI:C, a synthetic analog of double-stranded RNA activating PKR.	Poly I-C	77-84	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	4-7
27066702-5	2016	The PKR inhibition was sustained until 10h post infection in the presence of polyI:C, a synthetic analog of double-stranded RNA activating PKR.	Poly I-C	77-84	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	139-142
26902174-5	2016	Furthermore, LPS-, poly(I:C)- or TNF-alpha-induced insulin resistance was improved following suppression of ER stress, by increasing insulin-stimulated phosphorylation of IR-beta, IRS-1, GLUT-4 expression and glucose uptake.	Poly I-C	19-28	insulin	Homo sapiens	51-58
26902174-5	2016	Furthermore, LPS-, poly(I:C)- or TNF-alpha-induced insulin resistance was improved following suppression of ER stress, by increasing insulin-stimulated phosphorylation of IR-beta, IRS-1, GLUT-4 expression and glucose uptake.	Poly I-C	19-28	insulin	Homo sapiens	133-140
26902174-5	2016	Furthermore, LPS-, poly(I:C)- or TNF-alpha-induced insulin resistance was improved following suppression of ER stress, by increasing insulin-stimulated phosphorylation of IR-beta, IRS-1, GLUT-4 expression and glucose uptake.	Poly I-C	19-28	insulin receptor substrate 1	Homo sapiens	180-185
26902174-5	2016	Furthermore, LPS-, poly(I:C)- or TNF-alpha-induced insulin resistance was improved following suppression of ER stress, by increasing insulin-stimulated phosphorylation of IR-beta, IRS-1, GLUT-4 expression and glucose uptake.	Poly I-C	19-28	solute carrier family 2 member 4	Homo sapiens	187-193
26872595-6	2016	Prenatal PolyI:C treatment had long-term effects on CD11b and CD45 expression.	Poly I-C	9-16	integrin alpha M	Mus musculus	52-57
26872595-6	2016	Prenatal PolyI:C treatment had long-term effects on CD11b and CD45 expression.	Poly I-C	9-16	protein tyrosine phosphatase, receptor type, C	Mus musculus	62-66
27316386-10	2016	Furthermore, Poly(I:C) treated MSCs and untreated MSCs had comparable inhibitory effects on proliferation of T cells, and Poly(I:C) could enhance the expression of TLR3 at protein and mRNA level.	Poly I-C	13-21	toll-like receptor 3	Mus musculus	164-168
27079438-4	2016	Whereas the use of poly(I:C) or LAG-3-Ig as a signal adjuvant induced a slight enhancement of P1A vaccine effects compared to incomplete Freund"s adjuvant, combined treatment with poly(I:C) plus LAG-3-Ig remarkably potentiated antitumor effects, leading to complete rejection of pre-established tumor and long-term survival of mice.	Poly I-C	19-27	zinc finger protein 185	Mus musculus	94-97
27316386-10	2016	Furthermore, Poly(I:C) treated MSCs and untreated MSCs had comparable inhibitory effects on proliferation of T cells, and Poly(I:C) could enhance the expression of TLR3 at protein and mRNA level.	Poly I-C	122-130	toll-like receptor 3	Mus musculus	164-168
26895833-5	2016	The ability of the MLN4924 to inhibit IFN-beta production was confirmed in vivo, as mice treated with MLN4924 exhibited decreased levels of IFN-beta upon LPS or polyinosinic-polycytidylic acid stimulation.	Poly I-C	161-192	interferon beta 1, fibroblast	Mus musculus	38-46
26936212-9	2016	We noted that A20 significantly inhibited poly(I:C)-induced cytokine production, and this effect was related to the inhibition of NF-kappaB signaling.	Poly I-C	42-51	immunoglobulin kappa variable 1-27	Homo sapiens	14-17
26895833-5	2016	The ability of the MLN4924 to inhibit IFN-beta production was confirmed in vivo, as mice treated with MLN4924 exhibited decreased levels of IFN-beta upon LPS or polyinosinic-polycytidylic acid stimulation.	Poly I-C	161-192	interferon beta 1, fibroblast	Mus musculus	140-148
26423178-3	2016	We have previously reported that ISG56 and ISG54 are induced by polyinosinic-polycytidylic acid (poly IC), an authentic agonist for Toll-like receptor 3 (TLR3), in U373MG human astrocytoma cells.	Poly I-C	64-95	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	33-38
26935338-3	2016	In addition, Muc1 + polyinosinic:polycytidylic acid (poly I:C) was found to stimulate the expression levels of the surface molecules cluster of differentiation (CD)40, CD83 and CD80, and HLA-DRm and decreased the expression of CD14 in the dendritic cells, determined using fluorescence-activated cell sorting.	Poly I-C	53-61	mucin 1, cell surface associated	Homo sapiens	13-17
26935338-3	2016	In addition, Muc1 + polyinosinic:polycytidylic acid (poly I:C) was found to stimulate the expression levels of the surface molecules cluster of differentiation (CD)40, CD83 and CD80, and HLA-DRm and decreased the expression of CD14 in the dendritic cells, determined using fluorescence-activated cell sorting.	Poly I-C	53-61	CD83 molecule	Homo sapiens	168-172
26935338-3	2016	In addition, Muc1 + polyinosinic:polycytidylic acid (poly I:C) was found to stimulate the expression levels of the surface molecules cluster of differentiation (CD)40, CD83 and CD80, and HLA-DRm and decreased the expression of CD14 in the dendritic cells, determined using fluorescence-activated cell sorting.	Poly I-C	53-61	CD80 molecule	Homo sapiens	177-181
26935338-3	2016	In addition, Muc1 + polyinosinic:polycytidylic acid (poly I:C) was found to stimulate the expression levels of the surface molecules cluster of differentiation (CD)40, CD83 and CD80, and HLA-DRm and decreased the expression of CD14 in the dendritic cells, determined using fluorescence-activated cell sorting.	Poly I-C	53-61	CD14 molecule	Homo sapiens	227-231
26423178-3	2016	We have previously reported that ISG56 and ISG54 are induced by polyinosinic-polycytidylic acid (poly IC), an authentic agonist for Toll-like receptor 3 (TLR3), in U373MG human astrocytoma cells.	Poly I-C	64-95	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	43-48
26423178-3	2016	We have previously reported that ISG56 and ISG54 are induced by polyinosinic-polycytidylic acid (poly IC), an authentic agonist for Toll-like receptor 3 (TLR3), in U373MG human astrocytoma cells.	Poly I-C	64-95	toll like receptor 3	Homo sapiens	132-152
26423178-3	2016	We have previously reported that ISG56 and ISG54 are induced by polyinosinic-polycytidylic acid (poly IC), an authentic agonist for Toll-like receptor 3 (TLR3), in U373MG human astrocytoma cells.	Poly I-C	64-95	toll like receptor 3	Homo sapiens	154-158
26823206-4	2016	Mex3b(-/-) mice injected with poly(I:C) was more resistant to poly(I:C)-induced death.	Poly I-C	30-39	mex3 RNA binding family member B	Mus musculus	0-5
27022724-6	2016	Poly-IC induced IL-33 in OPC and addition of IL-33 to in vitro cultures, amplified further, IL-33 expression suggesting an autocrine regulation of IL-33.	Poly I-C	0-7	interleukin 33	Homo sapiens	16-21
27022724-9	2016	Also, poly-IC treated animals showed greater expression of IL-33 and higher expression of M2 phenotype macrophages in the CC.	Poly I-C	6-13	interleukin 33	Homo sapiens	59-64
26980664-3	2016	Here, we show that exposure to the TLR3 agonist polyinosinic-polycytidylic acid (poly(I:C)) or incubation with the TLR4 agonist lipopolysaccharide (LPS) increased the mRNA expression levels of TLR3, TLR4 and cytokines in hMSCs.	Poly I-C	48-79	toll like receptor 3	Homo sapiens	35-39
26980664-3	2016	Here, we show that exposure to the TLR3 agonist polyinosinic-polycytidylic acid (poly(I:C)) or incubation with the TLR4 agonist lipopolysaccharide (LPS) increased the mRNA expression levels of TLR3, TLR4 and cytokines in hMSCs.	Poly I-C	48-79	toll like receptor 4	Homo sapiens	115-119
26980664-3	2016	Here, we show that exposure to the TLR3 agonist polyinosinic-polycytidylic acid (poly(I:C)) or incubation with the TLR4 agonist lipopolysaccharide (LPS) increased the mRNA expression levels of TLR3, TLR4 and cytokines in hMSCs.	Poly I-C	48-79	toll like receptor 3	Homo sapiens	193-197
26980664-3	2016	Here, we show that exposure to the TLR3 agonist polyinosinic-polycytidylic acid (poly(I:C)) or incubation with the TLR4 agonist lipopolysaccharide (LPS) increased the mRNA expression levels of TLR3, TLR4 and cytokines in hMSCs.	Poly I-C	48-79	toll like receptor 4	Homo sapiens	199-203
27014268-4	2016	In this article, we show that activation of human BDCA-3 DCs with Poly I:C induces the expression of activation markers (CD40, CD80, and CD86) and immunoglobulin-like transcript (ILT) 3 and 4.	Poly I-C	66-74	thrombomodulin	Homo sapiens	50-56
27014268-4	2016	In this article, we show that activation of human BDCA-3 DCs with Poly I:C induces the expression of activation markers (CD40, CD80, and CD86) and immunoglobulin-like transcript (ILT) 3 and 4.	Poly I-C	66-74	CD40 molecule	Homo sapiens	121-125
27014268-4	2016	In this article, we show that activation of human BDCA-3 DCs with Poly I:C induces the expression of activation markers (CD40, CD80, and CD86) and immunoglobulin-like transcript (ILT) 3 and 4.	Poly I-C	66-74	CD80 molecule	Homo sapiens	127-131
27014268-4	2016	In this article, we show that activation of human BDCA-3 DCs with Poly I:C induces the expression of activation markers (CD40, CD80, and CD86) and immunoglobulin-like transcript (ILT) 3 and 4.	Poly I-C	66-74	CD86 molecule	Homo sapiens	137-141
27014268-4	2016	In this article, we show that activation of human BDCA-3 DCs with Poly I:C induces the expression of activation markers (CD40, CD80, and CD86) and immunoglobulin-like transcript (ILT) 3 and 4.	Poly I-C	66-74	leukocyte immunoglobulin like receptor B4	Homo sapiens	147-191
27014268-5	2016	This Poly I:C stimulation results in four populations identifiable by flow cytometry based on their expression of ILT3 and ILT4.	Poly I-C	5-13	leukocyte immunoglobulin like receptor B4	Homo sapiens	114-118
27014268-5	2016	This Poly I:C stimulation results in four populations identifiable by flow cytometry based on their expression of ILT3 and ILT4.	Poly I-C	5-13	leukocyte immunoglobulin like receptor B2	Homo sapiens	123-127
26985393-7	2016	For example, either TLR9 ligand, CpG, or TLR3 ligand, poly I:C, was capable of inducing among the highest 10% expression levels of CD86.	Poly I-C	54-62	toll like receptor 9	Homo sapiens	20-24
26985393-7	2016	For example, either TLR9 ligand, CpG, or TLR3 ligand, poly I:C, was capable of inducing among the highest 10% expression levels of CD86.	Poly I-C	54-62	toll like receptor 3	Homo sapiens	41-45
26985393-7	2016	For example, either TLR9 ligand, CpG, or TLR3 ligand, poly I:C, was capable of inducing among the highest 10% expression levels of CD86.	Poly I-C	54-62	CD86 molecule	Homo sapiens	131-135
26823206-4	2016	Mex3b(-/-) mice injected with poly(I:C) was more resistant to poly(I:C)-induced death.	Poly I-C	62-71	mex3 RNA binding family member B	Mus musculus	0-5
26848042-6	2016	The results showed that poly (I:C) transfection markedly induced HeLa apoptosis, increased the protein levels of pro-apoptotic B cell lymphoma-2 (Bcl-2)-associated X protein (Bax) and BH3 interacting-domain death agonist (Bid), and suppressed the protein expression levels of anti-apoptotic Bcl-2 and Survivin.	Poly I-C	24-34	BCL2 apoptosis regulator	Homo sapiens	146-151
26586642-7	2016	In addition, poly(I:C)- or Sendai virus (SeV)-induced IFN-beta expression in DEFs were significantly decreased by knock-down of duMAVS with siRNA.	Poly I-C	13-21	interferon beta 1	Homo sapiens	54-62
26848042-6	2016	The results showed that poly (I:C) transfection markedly induced HeLa apoptosis, increased the protein levels of pro-apoptotic B cell lymphoma-2 (Bcl-2)-associated X protein (Bax) and BH3 interacting-domain death agonist (Bid), and suppressed the protein expression levels of anti-apoptotic Bcl-2 and Survivin.	Poly I-C	24-34	BCL2 associated X, apoptosis regulator	Homo sapiens	175-178
26848042-6	2016	The results showed that poly (I:C) transfection markedly induced HeLa apoptosis, increased the protein levels of pro-apoptotic B cell lymphoma-2 (Bcl-2)-associated X protein (Bax) and BH3 interacting-domain death agonist (Bid), and suppressed the protein expression levels of anti-apoptotic Bcl-2 and Survivin.	Poly I-C	24-34	BH3 interacting domain death agonist	Homo sapiens	222-225
26848042-6	2016	The results showed that poly (I:C) transfection markedly induced HeLa apoptosis, increased the protein levels of pro-apoptotic B cell lymphoma-2 (Bcl-2)-associated X protein (Bax) and BH3 interacting-domain death agonist (Bid), and suppressed the protein expression levels of anti-apoptotic Bcl-2 and Survivin.	Poly I-C	24-34	BCL2 apoptosis regulator	Homo sapiens	291-296
26848042-8	2016	In addition, poly (I:C) transfection decreased  Psim, triggered the release of cytochrome c from the mitochondria to the cytosol, and induced caspase-9 and -3 activation.	Poly I-C	13-22	cytochrome c, somatic	Homo sapiens	79-91
26848042-8	2016	In addition, poly (I:C) transfection decreased  Psim, triggered the release of cytochrome c from the mitochondria to the cytosol, and induced caspase-9 and -3 activation.	Poly I-C	13-22	caspase 9	Homo sapiens	142-158
26848042-9	2016	IFN-beta knockdown decreased the poly (I:C)-induced production of ROS and DNA damage, restored  Psim and cytochrome c release, and suppressed caspase-9 and -3 activation, thereby suppressing poly (I:C)-mediated apoptosis in the HeLa cells.	Poly I-C	33-43	interferon beta 1	Homo sapiens	0-8
26848042-9	2016	IFN-beta knockdown decreased the poly (I:C)-induced production of ROS and DNA damage, restored  Psim and cytochrome c release, and suppressed caspase-9 and -3 activation, thereby suppressing poly (I:C)-mediated apoptosis in the HeLa cells.	Poly I-C	33-43	cytochrome c, somatic	Homo sapiens	105-117
26848042-9	2016	IFN-beta knockdown decreased the poly (I:C)-induced production of ROS and DNA damage, restored  Psim and cytochrome c release, and suppressed caspase-9 and -3 activation, thereby suppressing poly (I:C)-mediated apoptosis in the HeLa cells.	Poly I-C	33-43	caspase 9	Homo sapiens	142-158
26848042-9	2016	IFN-beta knockdown decreased the poly (I:C)-induced production of ROS and DNA damage, restored  Psim and cytochrome c release, and suppressed caspase-9 and -3 activation, thereby suppressing poly (I:C)-mediated apoptosis in the HeLa cells.	Poly I-C	191-201	interferon beta 1	Homo sapiens	0-8
26848042-9	2016	IFN-beta knockdown decreased the poly (I:C)-induced production of ROS and DNA damage, restored  Psim and cytochrome c release, and suppressed caspase-9 and -3 activation, thereby suppressing poly (I:C)-mediated apoptosis in the HeLa cells.	Poly I-C	191-201	cytochrome c, somatic	Homo sapiens	105-117
26603372-1	2016	Emerging experimental evidence suggests that activation of Toll-like receptor 3 (TLR3) by its agonist polyinosinic polycytidylic acid (poly-ICLC) protects neurons against cerebral ischemia, but the underlying mechanisms remain largely unknown.	Poly I-C	102-133	toll like receptor 3	Homo sapiens	59-79
26964720-5	2016	The structure of the three promoters (pMx1, pMx2 and pMx3) has been previously disclosed, and their response to poly I:C in RTG-2 cells characterized.	Poly I-C	112-120	paired related homeobox 2	Homo sapiens	44-48
26964720-12	2016	Interestingly, IPNV infection inhibited the induction caused by poly I:C, suggesting an antagonistic activity of IPNV on Mx2 transcription.	Poly I-C	64-72	interferon-induced GTP-binding protein Mx2	Oncorhynchus mykiss	121-124
26759009-5	2016	In this study, we analyzed the potential of polyinosinic:polycytidylic acid [poly(I:C)], a TLR3 agonist, to replace or complement BCG in the treatment of non-muscle-invasive bladder cancer.	Poly I-C	77-86	toll like receptor 3	Homo sapiens	91-95
26385575-7	2016	NeuN(+) IWMN density trended to be higher in offspring from dams exposed to polyI:C at GD19, but not GD10.	Poly I-C	76-83	RNA binding fox-1 homolog 3	Rattus norvegicus	0-4
26385575-10	2016	A positive correlation was observed between NeuN(+) and SST(+) IWMN density in animals exposed to polyI:C at GD19, but not controls.	Poly I-C	98-105	RNA binding fox-1 homolog 3	Rattus norvegicus	44-48
26603372-1	2016	Emerging experimental evidence suggests that activation of Toll-like receptor 3 (TLR3) by its agonist polyinosinic polycytidylic acid (poly-ICLC) protects neurons against cerebral ischemia, but the underlying mechanisms remain largely unknown.	Poly I-C	102-133	toll like receptor 3	Homo sapiens	81-85
26603372-1	2016	Emerging experimental evidence suggests that activation of Toll-like receptor 3 (TLR3) by its agonist polyinosinic polycytidylic acid (poly-ICLC) protects neurons against cerebral ischemia, but the underlying mechanisms remain largely unknown.	Poly I-C	135-144	toll like receptor 3	Homo sapiens	59-79
26603372-1	2016	Emerging experimental evidence suggests that activation of Toll-like receptor 3 (TLR3) by its agonist polyinosinic polycytidylic acid (poly-ICLC) protects neurons against cerebral ischemia, but the underlying mechanisms remain largely unknown.	Poly I-C	135-144	toll like receptor 3	Homo sapiens	81-85
26603372-13	2016	Also, oxygen-glucose deprivation (OGD) reduces TLR3 and IL-6 expression in microglia, but polyinosinic polycytidylic acid (poly-ICLC) rescues TLR3 and IL-6.	Poly I-C	90-121	toll like receptor 3	Homo sapiens	142-146
26603372-13	2016	Also, oxygen-glucose deprivation (OGD) reduces TLR3 and IL-6 expression in microglia, but polyinosinic polycytidylic acid (poly-ICLC) rescues TLR3 and IL-6.	Poly I-C	90-121	interleukin 6	Homo sapiens	151-155
26603372-13	2016	Also, oxygen-glucose deprivation (OGD) reduces TLR3 and IL-6 expression in microglia, but polyinosinic polycytidylic acid (poly-ICLC) rescues TLR3 and IL-6.	Poly I-C	123-132	toll like receptor 3	Homo sapiens	142-146
26603372-13	2016	Also, oxygen-glucose deprivation (OGD) reduces TLR3 and IL-6 expression in microglia, but polyinosinic polycytidylic acid (poly-ICLC) rescues TLR3 and IL-6.	Poly I-C	123-132	interleukin 6	Homo sapiens	151-155
26869429-3	2016	Polyriboinosinic-polyribocytidylic acid (polyI:C), a ligand for toll-like receptor 3, was selected as a model nucleic acid-based adjuvant.	Poly I-C	0-39	toll-like receptor 3	Mus musculus	64-84
26589477-8	2016	Examination of signaling pathways suggested that the poly(I:C) effects in fetal ASM involve TLR and ERK signaling, in addition to another major inflammatory pathway, NF-kappaB.	Poly I-C	53-61	EPH receptor B2	Homo sapiens	100-103
26869429-3	2016	Polyriboinosinic-polyribocytidylic acid (polyI:C), a ligand for toll-like receptor 3, was selected as a model nucleic acid-based adjuvant.	Poly I-C	41-48	toll-like receptor 3	Mus musculus	64-84
26869429-7	2016	PolyI:C-MgPP was more efficiently taken up by toll-like receptor 3-positive RAW264.7 cells than naked polyI:C, and its uptake stimulated increased tumor necrosis factor-alpha production.	Poly I-C	0-7	toll-like receptor 3	Mus musculus	46-66
26869429-7	2016	PolyI:C-MgPP was more efficiently taken up by toll-like receptor 3-positive RAW264.7 cells than naked polyI:C, and its uptake stimulated increased tumor necrosis factor-alpha production.	Poly I-C	0-7	tumor necrosis factor	Mus musculus	147-174
26869429-8	2016	When the presentation of ovalbumin (OVA), a model antigen, was evaluated after the addition of OVA along with naked polyI:C or polyI:C-MgPP to mouse dendritic DC2.4 cells, polyI:C-MgPP substantially increased OVA presentation.	Poly I-C	116-123	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	25-34
26641630-1	2016	We describe herein a Toll-like receptor 3 (TLR3) targeting delivery system based on mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic-polycytidylic acid (poly(I:C)) for controlled cargo delivery in SK-BR-3 breast carcinoma cells.	Poly I-C	162-193	toll like receptor 3	Homo sapiens	21-41
26641630-1	2016	We describe herein a Toll-like receptor 3 (TLR3) targeting delivery system based on mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic-polycytidylic acid (poly(I:C)) for controlled cargo delivery in SK-BR-3 breast carcinoma cells.	Poly I-C	162-193	toll like receptor 3	Homo sapiens	43-47
26641630-2	2016	Our results show that poly(I:C)-conjugated nanoparticles efficiently targeted breast cancer cells due to dsRNA-TLR3 interaction.	Poly I-C	22-31	toll like receptor 3	Homo sapiens	111-115
26793623-4	2015	First we confirmed that the protective effect of poly I:C against enteric infection of mice with Yersinia enterocolitica was dependent on TLR3-mediated TRIF signaling by using TLR3-deficient mice.	Poly I-C	49-57	toll-like receptor 3	Mus musculus	138-142
26780827-0	2016	Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia.	Poly I-C	0-8	prostaglandin E synthase	Mus musculus	38-45
26780827-0	2016	Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia.	Poly I-C	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	50-55
26780827-2	2016	Polyinosinic-polycytidylic acid [poly(I:C)] is a synthetic analog of dsRNA that activates different molecules, such as retinoic acid-inducible gene I, melanoma differentiation-associated gene 5, and toll-like receptor-3 (TLR3).	Poly I-C	0-31	toll-like receptor 3	Rattus norvegicus	221-225
26780827-5	2016	METHODS: In the present study, we evaluated the effect of poly(I:C) on the production of prostaglandin E2 (PGE2) and the inducible enzymes cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) in primary rat microglia.	Poly I-C	58-67	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	139-155
26780827-5	2016	METHODS: In the present study, we evaluated the effect of poly(I:C) on the production of prostaglandin E2 (PGE2) and the inducible enzymes cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) in primary rat microglia.	Poly I-C	58-67	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	157-162
26780827-9	2016	To investigate the mechanisms involved in poly(I:C)-induced COX-2 and mPGES-1, we studied the effects of various signal transduction pathway inhibitors.	Poly I-C	42-51	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	60-65
26780827-9	2016	To investigate the mechanisms involved in poly(I:C)-induced COX-2 and mPGES-1, we studied the effects of various signal transduction pathway inhibitors.	Poly I-C	42-51	prostaglandin E synthase	Mus musculus	70-77
26780827-16	2016	Importantly, poly(I:C) activates similar pathways also involved in TLR4 signaling that are important for COX-2 and mPGES-1 synthesis.	Poly I-C	13-21	toll-like receptor 4	Rattus norvegicus	67-71
26780827-16	2016	Importantly, poly(I:C) activates similar pathways also involved in TLR4 signaling that are important for COX-2 and mPGES-1 synthesis.	Poly I-C	13-21	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	105-110
26780827-16	2016	Importantly, poly(I:C) activates similar pathways also involved in TLR4 signaling that are important for COX-2 and mPGES-1 synthesis.	Poly I-C	13-21	prostaglandin E synthase	Mus musculus	115-122
26793623-4	2015	First we confirmed that the protective effect of poly I:C against enteric infection of mice with Yersinia enterocolitica was dependent on TLR3-mediated TRIF signaling by using TLR3-deficient mice.	Poly I-C	49-57	toll-like receptor adaptor molecule 2	Mus musculus	152-156
26793623-4	2015	First we confirmed that the protective effect of poly I:C against enteric infection of mice with Yersinia enterocolitica was dependent on TLR3-mediated TRIF signaling by using TLR3-deficient mice.	Poly I-C	49-57	toll-like receptor 3	Mus musculus	176-180
26793623-7	2015	Poly I:C induced IFN-gamma expression by NK cells in the MLN, which was mediated through type I IFNs and IL-12p40 from antigen presenting cells and consequent activation of STAT1 and STAT4 in NK cells.	Poly I-C	0-8	interferon gamma	Mus musculus	17-26
26793623-7	2015	Poly I:C induced IFN-gamma expression by NK cells in the MLN, which was mediated through type I IFNs and IL-12p40 from antigen presenting cells and consequent activation of STAT1 and STAT4 in NK cells.	Poly I-C	0-8	interleukin 12b	Mus musculus	105-113
26793623-7	2015	Poly I:C induced IFN-gamma expression by NK cells in the MLN, which was mediated through type I IFNs and IL-12p40 from antigen presenting cells and consequent activation of STAT1 and STAT4 in NK cells.	Poly I-C	0-8	signal transducer and activator of transcription 1	Mus musculus	173-178
26793623-7	2015	Poly I:C induced IFN-gamma expression by NK cells in the MLN, which was mediated through type I IFNs and IL-12p40 from antigen presenting cells and consequent activation of STAT1 and STAT4 in NK cells.	Poly I-C	0-8	signal transducer and activator of transcription 4	Mus musculus	183-188
26722842-9	2016	We have found that release of TGF-beta1 and IL-6 was TLR ligand [LPS and Poly(I:C)] concentration dependent and stronger in WJ-EPC than WJ-MSC cultures.	Poly I-C	73-82	transforming growth factor beta 1	Homo sapiens	30-39
26742695-8	2016	A similar lower intrinsic excitability was observed in CA1 pyramidal neurons from hippocampal slices of two weeks-old poly I:C offspring.	Poly I-C	118-126	carbonic anhydrase 1	Rattus norvegicus	55-58
26722842-9	2016	We have found that release of TGF-beta1 and IL-6 was TLR ligand [LPS and Poly(I:C)] concentration dependent and stronger in WJ-EPC than WJ-MSC cultures.	Poly I-C	73-82	interleukin 6	Homo sapiens	44-48
26470915-3	2016	Lipopolysaccharide (LPS) activates the Gram-negative bacterial receptor TLR4 and polyinosinic:polycytidylic acid (polyI:C) activates the viral receptor TLR3.	Poly I-C	81-112	toll-like receptor 3	Mus musculus	152-156
26520876-7	2016	The expression levels of IL-33 were elevated in RA FLS that had been stimulated with poly I:C, IL-1beta, and tumor necrosis factor (TNF)-alpha.	Poly I-C	85-93	interleukin 33	Homo sapiens	25-30
26470915-3	2016	Lipopolysaccharide (LPS) activates the Gram-negative bacterial receptor TLR4 and polyinosinic:polycytidylic acid (polyI:C) activates the viral receptor TLR3.	Poly I-C	114-121	toll-like receptor 3	Mus musculus	152-156
26579632-4	2016	TRIF was strongly expressed in PMCs and its deficiency led to impaired production of cytokines and chemokines by poly I:C and LPS in the cells.	Poly I-C	113-121	toll-like receptor adaptor molecule 1	Mus musculus	0-4
26470915-9	2016	Cytokine induction was delayed in polyI:C-treated TRIF(-/-) mice, indicating that multiple mechanisms mediating polyI:C signaling exist.	Poly I-C	34-41	toll-like receptor adaptor molecule 1	Mus musculus	50-54
26470915-9	2016	Cytokine induction was delayed in polyI:C-treated TRIF(-/-) mice, indicating that multiple mechanisms mediating polyI:C signaling exist.	Poly I-C	112-119	toll-like receptor adaptor molecule 1	Mus musculus	50-54
25416860-5	2016	Poly I:C significantly attenuated CSD-induced production of TNF-alpha and IFN-gamma in the brain as well as TNF-alpha and IL-4 in the spleen.	Poly I-C	0-8	interferon gamma	Rattus norvegicus	74-83
27639618-5	2016	METHODS: We treated human MCs with polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA, then analysed the IFI35 expression by reverse transcription-polymerase chain reaction and western blotting.	Poly I-C	35-66	interferon induced protein 35	Homo sapiens	130-135
27639618-5	2016	METHODS: We treated human MCs with polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA, then analysed the IFI35 expression by reverse transcription-polymerase chain reaction and western blotting.	Poly I-C	68-75	interferon induced protein 35	Homo sapiens	130-135
25416860-3	2016	TLR3 agonist poly I:C exerts anti-inflammatory effect and prevents cell injury in the brain.	Poly I-C	13-21	toll-like receptor 3	Rattus norvegicus	0-4
26307945-6	2016	We co-incubated Borrelia with human keratinocytes in the presence of poly (I: C), a dsRNA TLR3 agonist generated by skin injury.	Poly I-C	69-80	toll like receptor 3	Homo sapiens	90-94
25416860-5	2016	Poly I:C significantly attenuated CSD-induced production of TNF-alpha and IFN-gamma in the brain as well as TNF-alpha and IL-4 in the spleen.	Poly I-C	0-8	tumor necrosis factor	Rattus norvegicus	108-117
25416860-4	2016	The aim of the present study was to examine the effect of systemic administration of poly I:C on the release of cytokines (TNF-alpha, IFN-gamma, IL-4, TGF-beta1, and GM-CSF) in the brain and spleen, splenic lymphocyte proliferation, expression of GAD65, GABAAalpha, GABAAbeta as well as Hsp70, and production of dark neurons after induction of repetitive CSD in juvenile rats.	Poly I-C	85-93	tumor necrosis factor	Rattus norvegicus	123-132
25416860-4	2016	The aim of the present study was to examine the effect of systemic administration of poly I:C on the release of cytokines (TNF-alpha, IFN-gamma, IL-4, TGF-beta1, and GM-CSF) in the brain and spleen, splenic lymphocyte proliferation, expression of GAD65, GABAAalpha, GABAAbeta as well as Hsp70, and production of dark neurons after induction of repetitive CSD in juvenile rats.	Poly I-C	85-93	interferon gamma	Rattus norvegicus	134-143
27771719-11	2016	Finally, intraneural injection of polyinosinic-polycytidylic acid, a synthetic TLR3 agonist, induced macrophage infiltration into the sciatic nerve in vivo.	Poly I-C	34-65	toll-like receptor 3	Mus musculus	79-83
25416860-4	2016	The aim of the present study was to examine the effect of systemic administration of poly I:C on the release of cytokines (TNF-alpha, IFN-gamma, IL-4, TGF-beta1, and GM-CSF) in the brain and spleen, splenic lymphocyte proliferation, expression of GAD65, GABAAalpha, GABAAbeta as well as Hsp70, and production of dark neurons after induction of repetitive CSD in juvenile rats.	Poly I-C	85-93	interleukin 4	Rattus norvegicus	145-149
25416860-4	2016	The aim of the present study was to examine the effect of systemic administration of poly I:C on the release of cytokines (TNF-alpha, IFN-gamma, IL-4, TGF-beta1, and GM-CSF) in the brain and spleen, splenic lymphocyte proliferation, expression of GAD65, GABAAalpha, GABAAbeta as well as Hsp70, and production of dark neurons after induction of repetitive CSD in juvenile rats.	Poly I-C	85-93	transforming growth factor, beta 1	Rattus norvegicus	151-160
25416860-4	2016	The aim of the present study was to examine the effect of systemic administration of poly I:C on the release of cytokines (TNF-alpha, IFN-gamma, IL-4, TGF-beta1, and GM-CSF) in the brain and spleen, splenic lymphocyte proliferation, expression of GAD65, GABAAalpha, GABAAbeta as well as Hsp70, and production of dark neurons after induction of repetitive CSD in juvenile rats.	Poly I-C	85-93	colony stimulating factor 2	Rattus norvegicus	166-172
25416860-4	2016	The aim of the present study was to examine the effect of systemic administration of poly I:C on the release of cytokines (TNF-alpha, IFN-gamma, IL-4, TGF-beta1, and GM-CSF) in the brain and spleen, splenic lymphocyte proliferation, expression of GAD65, GABAAalpha, GABAAbeta as well as Hsp70, and production of dark neurons after induction of repetitive CSD in juvenile rats.	Poly I-C	85-93	glutamate decarboxylase 2	Rattus norvegicus	247-252
25416860-5	2016	Poly I:C significantly attenuated CSD-induced production of TNF-alpha and IFN-gamma in the brain as well as TNF-alpha and IL-4 in the spleen.	Poly I-C	0-8	tumor necrosis factor	Rattus norvegicus	60-69
26772774-13	2016	Pretreating macrophages with an ERK inhibitor, U0126, dose-dependently antagonized WISP"s synergistic effect on Poly(I:C)-induced TNF-alpha release.	Poly I-C	112-121	mitogen-activated protein kinase 1	Mus musculus	32-35
26772774-13	2016	Pretreating macrophages with an ERK inhibitor, U0126, dose-dependently antagonized WISP"s synergistic effect on Poly(I:C)-induced TNF-alpha release.	Poly I-C	112-121	tumor necrosis factor	Mus musculus	130-139
26772774-14	2016	In conclusion, MTV exaggerates Poly(I:C)-induced lung injury in a WISP1 and integrin beta3 dependent manner, involving, at least part, the activation of the ERK pathway.	Poly I-C	31-40	cellular communication network factor 4	Mus musculus	66-71
26772774-14	2016	In conclusion, MTV exaggerates Poly(I:C)-induced lung injury in a WISP1 and integrin beta3 dependent manner, involving, at least part, the activation of the ERK pathway.	Poly I-C	31-40	integrin beta 3	Mus musculus	76-90
26772774-14	2016	In conclusion, MTV exaggerates Poly(I:C)-induced lung injury in a WISP1 and integrin beta3 dependent manner, involving, at least part, the activation of the ERK pathway.	Poly I-C	31-40	mitogen-activated protein kinase 1	Mus musculus	157-160
26446017-8	2016	Poly(I:C)-dependent expression of TNFR2 but not TNFR1 was enhanced by TNFalpha.	Poly I-C	0-9	tumor necrosis factor	Homo sapiens	70-78
26772774-0	2016	MECHANICAL VENTILATION AUGMENTS POLY(I:C)INDUCED LUNG INJURY VIA A WISP1-INTEGRIN beta3 DEPENDENT PATHWAY IN MICE.	Poly I-C	32-41	cellular communication network factor 4	Mus musculus	67-72
26772774-0	2016	MECHANICAL VENTILATION AUGMENTS POLY(I:C)INDUCED LUNG INJURY VIA A WISP1-INTEGRIN beta3 DEPENDENT PATHWAY IN MICE.	Poly I-C	32-41	integrin beta 3	Mus musculus	73-87
26772774-9	2016	MTV further increased Poly(I:C)-induced integrin beta3 expression in the lung.	Poly I-C	22-31	integrin beta 3	Mus musculus	40-54
26772774-11	2016	WISP1 significantly increased Poly(I:C)-induced TNF-alpha production in macrophages isolated from WT mice but not in macrophages isolated from beta3 knock-out mice.	Poly I-C	30-39	cellular communication network factor 4	Mus musculus	0-5
26772774-11	2016	WISP1 significantly increased Poly(I:C)-induced TNF-alpha production in macrophages isolated from WT mice but not in macrophages isolated from beta3 knock-out mice.	Poly I-C	30-39	tumor necrosis factor	Mus musculus	48-57
26477783-6	2016	RESULTS: LPS, fMLP, imiquimod and R848 stimulated the release of CXCL8, NE and MMP-9 whereas poly I:C selectively induced CXCL8 release only.	Poly I-C	93-101	formyl peptide receptor 1	Homo sapiens	14-18
26477783-6	2016	RESULTS: LPS, fMLP, imiquimod and R848 stimulated the release of CXCL8, NE and MMP-9 whereas poly I:C selectively induced CXCL8 release only.	Poly I-C	93-101	C-X-C motif chemokine ligand 8	Homo sapiens	122-127
27057425-2	2016	This function-defined TLR3 ligand, named ARNAX, acts as an adjuvant to induce antitumor CTL and NK without significant cytokinemia in mice, and thus superior to polyI:C for therapeutic vaccine immunotherapy against tumor.	Poly I-C	161-168	toll-like receptor 3	Mus musculus	22-26
26668716-7	2015	Stimulation with Poly(I:C) resulted in a significant increased secretion of IL-4, IL-6, RANTES, IP-10, MIP-1beta, VEGF, FGF, IL-1RA, IL-2R and G-CSF.	Poly I-C	17-25	interleukin 4	Homo sapiens	76-80
26668716-7	2015	Stimulation with Poly(I:C) resulted in a significant increased secretion of IL-4, IL-6, RANTES, IP-10, MIP-1beta, VEGF, FGF, IL-1RA, IL-2R and G-CSF.	Poly I-C	17-25	interleukin 6	Homo sapiens	82-86
26668716-7	2015	Stimulation with Poly(I:C) resulted in a significant increased secretion of IL-4, IL-6, RANTES, IP-10, MIP-1beta, VEGF, FGF, IL-1RA, IL-2R and G-CSF.	Poly I-C	17-25	C-C motif chemokine ligand 5	Homo sapiens	88-94
26668716-7	2015	Stimulation with Poly(I:C) resulted in a significant increased secretion of IL-4, IL-6, RANTES, IP-10, MIP-1beta, VEGF, FGF, IL-1RA, IL-2R and G-CSF.	Poly I-C	17-25	C-X-C motif chemokine ligand 10	Homo sapiens	96-101
26668716-7	2015	Stimulation with Poly(I:C) resulted in a significant increased secretion of IL-4, IL-6, RANTES, IP-10, MIP-1beta, VEGF, FGF, IL-1RA, IL-2R and G-CSF.	Poly I-C	17-25	C-C motif chemokine ligand 4	Homo sapiens	103-112
26668716-7	2015	Stimulation with Poly(I:C) resulted in a significant increased secretion of IL-4, IL-6, RANTES, IP-10, MIP-1beta, VEGF, FGF, IL-1RA, IL-2R and G-CSF.	Poly I-C	17-25	vascular endothelial growth factor A	Homo sapiens	114-118
26668716-7	2015	Stimulation with Poly(I:C) resulted in a significant increased secretion of IL-4, IL-6, RANTES, IP-10, MIP-1beta, VEGF, FGF, IL-1RA, IL-2R and G-CSF.	Poly I-C	17-25	interleukin 1 receptor antagonist	Homo sapiens	125-131
26668716-7	2015	Stimulation with Poly(I:C) resulted in a significant increased secretion of IL-4, IL-6, RANTES, IP-10, MIP-1beta, VEGF, FGF, IL-1RA, IL-2R and G-CSF.	Poly I-C	17-25	interleukin 2 receptor subunit alpha	Homo sapiens	133-138
26668716-7	2015	Stimulation with Poly(I:C) resulted in a significant increased secretion of IL-4, IL-6, RANTES, IP-10, MIP-1beta, VEGF, FGF, IL-1RA, IL-2R and G-CSF.	Poly I-C	17-25	colony stimulating factor 3	Homo sapiens	143-148
26658504-1	2015	PURPOSE: Innate immune signaling elicited by polyinosinic-polycytidylic acid (poly I:C) induces IL-7 production and early inflammatory responses in the salivary gland and accelerates the development of Sjogren"s syndrome (SS)-like sialadenitis.	Poly I-C	45-76	interleukin 7	Mus musculus	96-100
26395101-10	2015	Bacillus Calmette-Guerin peptidoglycan and polyinosinic-polycytidylic acid are representative agonists for TLR2 and TLR3, respectively, although they additionally stimulate cytoplasmic sensors: their functional specificities may not be limited to the relevant TLRs.	Poly I-C	43-74	toll like receptor 2	Homo sapiens	107-111
26395101-10	2015	Bacillus Calmette-Guerin peptidoglycan and polyinosinic-polycytidylic acid are representative agonists for TLR2 and TLR3, respectively, although they additionally stimulate cytoplasmic sensors: their functional specificities may not be limited to the relevant TLRs.	Poly I-C	43-74	toll like receptor 3	Homo sapiens	116-120
26646717-5	2015	HBD3 exacerbated the production of type I Interferon-beta in response to the viral ligand mimic polyinosinic:polycytidylic acid (polyI:C) in both human and mouse primary cells, although production of the chemokine CXCL10 was suppressed.	Poly I-C	129-136	defensin beta 103B	Homo sapiens	0-4
26646717-5	2015	HBD3 exacerbated the production of type I Interferon-beta in response to the viral ligand mimic polyinosinic:polycytidylic acid (polyI:C) in both human and mouse primary cells, although production of the chemokine CXCL10 was suppressed.	Poly I-C	129-136	interferon beta 1, fibroblast	Mus musculus	42-57
26646717-6	2015	Compared to polyI:C alone, mice injected with both hBD3 peptide and polyI:C also showed an enhanced increase in Interferon-beta.	Poly I-C	12-19	defensin beta 103B	Homo sapiens	51-55
26646717-6	2015	Compared to polyI:C alone, mice injected with both hBD3 peptide and polyI:C also showed an enhanced increase in Interferon-beta.	Poly I-C	68-75	interferon beta 1, fibroblast	Mus musculus	112-127
26646717-7	2015	Mice expressing a transgene encoding hBD3 had elevated basal levels of Interferon-beta, and challenge with polyI:C further increased this response.	Poly I-C	107-114	defensin beta 103B	Homo sapiens	37-41
26646717-8	2015	HBD3 peptide increased uptake of polyI:C by macrophages, however the cellular response and localisation of polyI:C in cells treated contemporaneously with hBD3 or cationic liposome differed.	Poly I-C	33-40	defensin beta 103B	Homo sapiens	0-4
26646717-8	2015	HBD3 peptide increased uptake of polyI:C by macrophages, however the cellular response and localisation of polyI:C in cells treated contemporaneously with hBD3 or cationic liposome differed.	Poly I-C	107-114	defensin beta 103B	Homo sapiens	0-4
26646717-8	2015	HBD3 peptide increased uptake of polyI:C by macrophages, however the cellular response and localisation of polyI:C in cells treated contemporaneously with hBD3 or cationic liposome differed.	Poly I-C	107-114	defensin beta 103B	Homo sapiens	155-159
26646717-9	2015	Immunohistochemistry showed that hBD3 and polyI:C do not co-localise, but in the presence of hBD3 less polyI:C localises to the early endosome.	Poly I-C	103-110	defensin beta 103B	Homo sapiens	93-97
26646717-10	2015	Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 suppresses the polyI:C-induced TLR3 response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1) and MAVS (IPS1/CARDIF).	Poly I-C	97-104	defensin beta 103B	Homo sapiens	77-81
26646717-10	2015	Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 suppresses the polyI:C-induced TLR3 response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1) and MAVS (IPS1/CARDIF).	Poly I-C	97-104	toll-like receptor 3	Mus musculus	113-117
26646717-10	2015	Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 suppresses the polyI:C-induced TLR3 response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1) and MAVS (IPS1/CARDIF).	Poly I-C	97-104	toll-like receptor adaptor molecule 1	Mus musculus	139-145
26646717-10	2015	Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 suppresses the polyI:C-induced TLR3 response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1) and MAVS (IPS1/CARDIF).	Poly I-C	97-104	toll-like receptor adaptor molecule 1	Mus musculus	147-151
26646717-10	2015	Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 suppresses the polyI:C-induced TLR3 response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1) and MAVS (IPS1/CARDIF).	Poly I-C	97-104	interferon induced with helicase C domain 1	Mus musculus	212-217
26646717-10	2015	Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 suppresses the polyI:C-induced TLR3 response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1) and MAVS (IPS1/CARDIF).	Poly I-C	97-104	mitochondrial antiviral signaling protein	Mus musculus	223-227
26646717-10	2015	Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 suppresses the polyI:C-induced TLR3 response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1) and MAVS (IPS1/CARDIF).	Poly I-C	97-104	mitochondrial antiviral signaling protein	Mus musculus	229-233
26646717-10	2015	Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 suppresses the polyI:C-induced TLR3 response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1) and MAVS (IPS1/CARDIF).	Poly I-C	97-104	mitochondrial antiviral signaling protein	Mus musculus	234-240
26658504-1	2015	PURPOSE: Innate immune signaling elicited by polyinosinic-polycytidylic acid (poly I:C) induces IL-7 production and early inflammatory responses in the salivary gland and accelerates the development of Sjogren"s syndrome (SS)-like sialadenitis.	Poly I-C	78-86	interleukin 7	Mus musculus	96-100
26658504-9	2015	RESULTS: Administration of poly I:C induced IL-7 gene expression and protein production in the LAC.	Poly I-C	27-35	interleukin 7	Mus musculus	44-48
26658504-10	2015	Poly I:C also induced the expression of CXCR3 ligands, monocyte chemoattractant protein-1, IL-23p19, and TNF-alpha in the LAC in an IL-7-dependent fashion.	Poly I-C	0-8	chemokine (C-X-C motif) receptor 3	Mus musculus	40-45
26658504-10	2015	Poly I:C also induced the expression of CXCR3 ligands, monocyte chemoattractant protein-1, IL-23p19, and TNF-alpha in the LAC in an IL-7-dependent fashion.	Poly I-C	0-8	chemokine (C-C motif) ligand 2	Mus musculus	55-89
26658504-10	2015	Poly I:C also induced the expression of CXCR3 ligands, monocyte chemoattractant protein-1, IL-23p19, and TNF-alpha in the LAC in an IL-7-dependent fashion.	Poly I-C	0-8	interleukin 23, alpha subunit p19	Mus musculus	91-99
26658504-10	2015	Poly I:C also induced the expression of CXCR3 ligands, monocyte chemoattractant protein-1, IL-23p19, and TNF-alpha in the LAC in an IL-7-dependent fashion.	Poly I-C	0-8	tumor necrosis factor	Mus musculus	105-114
26658504-10	2015	Poly I:C also induced the expression of CXCR3 ligands, monocyte chemoattractant protein-1, IL-23p19, and TNF-alpha in the LAC in an IL-7-dependent fashion.	Poly I-C	0-8	interleukin 7	Mus musculus	132-136
26658504-11	2015	Similarly to poly I:C, administration of exogenous IL-7 also up-regulated these proinflammatory mediators.	Poly I-C	13-21	interleukin 7	Mus musculus	51-55
26658504-13	2015	CONCLUSIONS: Poly I:C induces IL-7 production, early inflammatory responses, and characteristic pathologies of SS-like dacryoadenitis in non-autoimmune-prone C57BL/6 mice.	Poly I-C	13-21	interleukin 7	Mus musculus	30-34
26505478-7	2015	Comprehensive chemokine analysis showed that, compared with poly(I:C) alone, co-stimulation of BEAS-2B cells with IL-17A and poly(I:C) strongly induced production of such neutrophil chemoattractants as CXC chemokine ligand (CXCL)8, growth-related oncogene (GRO), and CXCL1.	Poly I-C	60-68	interleukin 17A	Homo sapiens	114-120
26535029-5	2015	RESULTS: The expression of ISG54 gene, a known responder to virus infection and Poly I:C treatment, was significantly induced in transfected cells compared with mock-transfected cells.	Poly I-C	80-88	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	27-32
26535029-9	2015	Immunoblotting confirmed the up-regulation of Eno1 and Tpi1 in PaKiT03 cells following Poly I:C transfection.	Poly I-C	87-95	enolase 1	Homo sapiens	46-50
26535029-9	2015	Immunoblotting confirmed the up-regulation of Eno1 and Tpi1 in PaKiT03 cells following Poly I:C transfection.	Poly I-C	87-95	triosephosphate isomerase 1	Homo sapiens	55-59
26134179-4	2015	Mice-treated with poly (I:C) showed thrombocytopaenia, an increase in mean platelet volume and abnormal haemostatic and inflammatory platelet-mediated functionality, indicated by decreased fibrinogen binding and platelet adhesion, prolonged tail bleeding times and impaired P-Selectin externalisation, RANTES release and thrombin-induced platelet-neutrophil aggregate formation.	Poly I-C	18-27	selectin, platelet	Mus musculus	274-284
26452032-7	2015	In comparison with IFN alpha or beta, IFN gamma treatment remarkably augmented apoptosis in PC-3 cells induced with polyinosinic:polycytidylic acid (poly I:C), a synthesized form of dsRNA.	Poly I-C	116-147	interferon gamma	Homo sapiens	38-47
26452032-7	2015	In comparison with IFN alpha or beta, IFN gamma treatment remarkably augmented apoptosis in PC-3 cells induced with polyinosinic:polycytidylic acid (poly I:C), a synthesized form of dsRNA.	Poly I-C	149-157	interferon gamma	Homo sapiens	38-47
26494128-7	2015	RESULTS: In vitro, Poly IC inhibited astrocyte proliferation, upregulated Toll-like receptor 3 (TLR3) expression, upregulated interferon-beta, and downregulated interleukin-6 production.	Poly I-C	19-26	toll-like receptor 3	Rattus norvegicus	74-94
26494128-7	2015	RESULTS: In vitro, Poly IC inhibited astrocyte proliferation, upregulated Toll-like receptor 3 (TLR3) expression, upregulated interferon-beta, and downregulated interleukin-6 production.	Poly I-C	19-26	toll-like receptor 3	Rattus norvegicus	96-100
26494128-7	2015	RESULTS: In vitro, Poly IC inhibited astrocyte proliferation, upregulated Toll-like receptor 3 (TLR3) expression, upregulated interferon-beta, and downregulated interleukin-6 production.	Poly I-C	19-26	interferon beta 1	Rattus norvegicus	126-141
26494128-7	2015	RESULTS: In vitro, Poly IC inhibited astrocyte proliferation, upregulated Toll-like receptor 3 (TLR3) expression, upregulated interferon-beta, and downregulated interleukin-6 production.	Poly I-C	19-26	interleukin 6	Rattus norvegicus	161-174
26385519-6	2015	A drastic reduction in cytokine production was observed in S100A9-knockout (KO) primary macrophages following RNA virus infection and treatment of cells with polyinosinic-polycytidylic acid (polyIC; a dsRNA mimetic that acts as a TLR3 agonist).	Poly I-C	158-189	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	59-65
26385519-6	2015	A drastic reduction in cytokine production was observed in S100A9-knockout (KO) primary macrophages following RNA virus infection and treatment of cells with polyinosinic-polycytidylic acid (polyIC; a dsRNA mimetic that acts as a TLR3 agonist).	Poly I-C	158-189	toll-like receptor 3	Mus musculus	230-234
26385519-6	2015	A drastic reduction in cytokine production was observed in S100A9-knockout (KO) primary macrophages following RNA virus infection and treatment of cells with polyinosinic-polycytidylic acid (polyIC; a dsRNA mimetic that acts as a TLR3 agonist).	Poly I-C	191-197	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	59-65
26385519-6	2015	A drastic reduction in cytokine production was observed in S100A9-knockout (KO) primary macrophages following RNA virus infection and treatment of cells with polyinosinic-polycytidylic acid (polyIC; a dsRNA mimetic that acts as a TLR3 agonist).	Poly I-C	191-197	toll-like receptor 3	Mus musculus	230-234
26385519-8	2015	S100A9-TLR3 interaction was critical for maturation of TLR3 containing EE into LE because TLR3 could not be detected in the LE of polyIC-treated S100A9-KO macrophages.	Poly I-C	130-136	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	0-6
26385519-8	2015	S100A9-TLR3 interaction was critical for maturation of TLR3 containing EE into LE because TLR3 could not be detected in the LE of polyIC-treated S100A9-KO macrophages.	Poly I-C	130-136	toll-like receptor 3	Mus musculus	7-11
26392465-3	2015	In this study, we report that preconditioning with the synthetic dsRNA polyinosinic-polycytidylic acid [poly(I:C)], a mimetic of viral RNA, rapidly reprograms murine APCs by simultaneously augmenting sensitivity of endosomal TLRs and inhibiting activation of RIG-I-like receptors (RLRs) in an IFN-beta-dependent manner.	Poly I-C	71-102	amyloid P component, serum	Mus musculus	166-170
26392465-3	2015	In this study, we report that preconditioning with the synthetic dsRNA polyinosinic-polycytidylic acid [poly(I:C)], a mimetic of viral RNA, rapidly reprograms murine APCs by simultaneously augmenting sensitivity of endosomal TLRs and inhibiting activation of RIG-I-like receptors (RLRs) in an IFN-beta-dependent manner.	Poly I-C	71-102	interferon beta 1, fibroblast	Mus musculus	293-301
26392465-3	2015	In this study, we report that preconditioning with the synthetic dsRNA polyinosinic-polycytidylic acid [poly(I:C)], a mimetic of viral RNA, rapidly reprograms murine APCs by simultaneously augmenting sensitivity of endosomal TLRs and inhibiting activation of RIG-I-like receptors (RLRs) in an IFN-beta-dependent manner.	Poly I-C	104-113	amyloid P component, serum	Mus musculus	166-170
26392465-3	2015	In this study, we report that preconditioning with the synthetic dsRNA polyinosinic-polycytidylic acid [poly(I:C)], a mimetic of viral RNA, rapidly reprograms murine APCs by simultaneously augmenting sensitivity of endosomal TLRs and inhibiting activation of RIG-I-like receptors (RLRs) in an IFN-beta-dependent manner.	Poly I-C	104-113	interferon beta 1, fibroblast	Mus musculus	293-301
25724934-10	2015	Moreover, Poly I:C treatment (2) enhanced aortic phenylephrine-induced maximum contraction, which was suppressed by PD98059 (ERK1/2 inhibitor), and (3) increased aortic levels of phosphorylated IRF3 and ERK1/2.	Poly I-C	10-18	mitogen-activated protein kinase 3	Mus musculus	125-131
25724934-10	2015	Moreover, Poly I:C treatment (2) enhanced aortic phenylephrine-induced maximum contraction, which was suppressed by PD98059 (ERK1/2 inhibitor), and (3) increased aortic levels of phosphorylated IRF3 and ERK1/2.	Poly I-C	10-18	interferon regulatory factor 3	Mus musculus	194-198
25724934-10	2015	Moreover, Poly I:C treatment (2) enhanced aortic phenylephrine-induced maximum contraction, which was suppressed by PD98059 (ERK1/2 inhibitor), and (3) increased aortic levels of phosphorylated IRF3 and ERK1/2.	Poly I-C	10-18	mitogen-activated protein kinase 3	Mus musculus	203-209
25724934-11	2015	Stimulation of mouse aortic VSMCs with Poly I:C resulted in increased phosphorylation of IRF3, ERK1/2, MLC, and CaD.	Poly I-C	39-47	interferon regulatory factor 3	Mus musculus	89-93
25724934-11	2015	Stimulation of mouse aortic VSMCs with Poly I:C resulted in increased phosphorylation of IRF3, ERK1/2, MLC, and CaD.	Poly I-C	39-47	mitogen-activated protein kinase 3	Mus musculus	95-101
25724934-11	2015	Stimulation of mouse aortic VSMCs with Poly I:C resulted in increased phosphorylation of IRF3, ERK1/2, MLC, and CaD.	Poly I-C	39-47	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	103-106
25724934-12	2015	Inhibition of ERK1/2 abolished Poly I:C-mediated phosphorylation of MLC and CaD.	Poly I-C	31-39	mitogen-activated protein kinase 3	Mus musculus	14-20
25724934-12	2015	Inhibition of ERK1/2 abolished Poly I:C-mediated phosphorylation of MLC and CaD.	Poly I-C	31-39	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	68-71
26134179-4	2015	Mice-treated with poly (I:C) showed thrombocytopaenia, an increase in mean platelet volume and abnormal haemostatic and inflammatory platelet-mediated functionality, indicated by decreased fibrinogen binding and platelet adhesion, prolonged tail bleeding times and impaired P-Selectin externalisation, RANTES release and thrombin-induced platelet-neutrophil aggregate formation.	Poly I-C	18-27	coagulation factor II	Mus musculus	321-329
26505478-9	2015	Poly(I:C) induced chemokine expression by BEAS-2B cells mainly via Toll-like receptor 3/TIR-domain-containing adapter-inducing interferon-beta-mediated signals.	Poly I-C	0-8	toll like receptor 3	Homo sapiens	67-87
26342798-7	2015	BM-MSC administration suppressed the elevation of expression of S1PR5 in the liver induced by PolyI:C injection.	Poly I-C	94-101	sphingosine-1-phosphate receptor 5	Mus musculus	64-69
26494305-7	2015	In contrast, the allergic airway inflammation induced by ovalbumin administration to sensitized mice caused AHR in the whole lung along with an increase in eosinophils and lymphocytes in the BALF and lung.When poly(I:C) + LPS were given to mice with an ongoing allergic airway inflammation induced by ovalbumin, the AHR was further increased in the peripheral lung and neutrophils appeared together with eosinophils and lymphocytes in the BALF and lung.	Poly I-C	210-219	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	57-66
26494305-7	2015	In contrast, the allergic airway inflammation induced by ovalbumin administration to sensitized mice caused AHR in the whole lung along with an increase in eosinophils and lymphocytes in the BALF and lung.When poly(I:C) + LPS were given to mice with an ongoing allergic airway inflammation induced by ovalbumin, the AHR was further increased in the peripheral lung and neutrophils appeared together with eosinophils and lymphocytes in the BALF and lung.	Poly I-C	210-219	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	301-310
32262767-1	2015	Polyinosinic-polycytidylic acid (poly(I:C)) is a synthetic double-stranded RNA (dsRNA) analog able to induce apoptosis in different cancer cells by the activation of toll-like receptor 3 (TLR3) and cytosolic helicases, retinoic acid inducible gene I (RIG-I) like receptors.	Poly I-C	0-31	toll like receptor 3	Homo sapiens	166-186
26392466-7	2015	Furthermore, knockdown of chSTING blocked polyinosinic-polycytidylic acid-, poly(deoxyadenylic-deoxythymidylic) acid-, and melanoma differentiation-associated gene 5 (MDA5)-stimulated induction of IFN-beta.	Poly I-C	42-73	interferon omega 1	Gallus gallus	197-205
32262767-1	2015	Polyinosinic-polycytidylic acid (poly(I:C)) is a synthetic double-stranded RNA (dsRNA) analog able to induce apoptosis in different cancer cells by the activation of toll-like receptor 3 (TLR3) and cytosolic helicases, retinoic acid inducible gene I (RIG-I) like receptors.	Poly I-C	0-31	toll like receptor 3	Homo sapiens	188-192
32262767-1	2015	Polyinosinic-polycytidylic acid (poly(I:C)) is a synthetic double-stranded RNA (dsRNA) analog able to induce apoptosis in different cancer cells by the activation of toll-like receptor 3 (TLR3) and cytosolic helicases, retinoic acid inducible gene I (RIG-I) like receptors.	Poly I-C	33-42	toll like receptor 3	Homo sapiens	166-186
32262767-1	2015	Polyinosinic-polycytidylic acid (poly(I:C)) is a synthetic double-stranded RNA (dsRNA) analog able to induce apoptosis in different cancer cells by the activation of toll-like receptor 3 (TLR3) and cytosolic helicases, retinoic acid inducible gene I (RIG-I) like receptors.	Poly I-C	33-42	toll like receptor 3	Homo sapiens	188-192
26817207-5	2015	Poly I: C significantly increased the TLRs 2 and 9 protein expressions whereas the TLRs 3 and 4 were reduced.	Poly I-C	0-9	toll like receptor 2	Homo sapiens	38-50
26255711-0	2015	Poly(I:C) induces expressions of MMP-1, -2, and -3 through various signaling pathways including IRF3 in human skin fibroblasts.	Poly I-C	0-8	matrix metallopeptidase 1	Homo sapiens	33-50
26255711-0	2015	Poly(I:C) induces expressions of MMP-1, -2, and -3 through various signaling pathways including IRF3 in human skin fibroblasts.	Poly I-C	0-8	interferon regulatory factor 3	Homo sapiens	96-100
26255711-10	2015	Poly(I:C) also induced activations of the mitogen-activated protein kinases (MAPKs), the nuclear factor-kappaB (NF-kappaB) and the interferon regulatory factor 3 (IRF3) pathways.	Poly I-C	0-8	nuclear factor kappa B subunit 1	Homo sapiens	89-110
26255711-10	2015	Poly(I:C) also induced activations of the mitogen-activated protein kinases (MAPKs), the nuclear factor-kappaB (NF-kappaB) and the interferon regulatory factor 3 (IRF3) pathways.	Poly I-C	0-8	nuclear factor kappa B subunit 1	Homo sapiens	112-121
26255711-10	2015	Poly(I:C) also induced activations of the mitogen-activated protein kinases (MAPKs), the nuclear factor-kappaB (NF-kappaB) and the interferon regulatory factor 3 (IRF3) pathways.	Poly I-C	0-8	interferon regulatory factor 3	Homo sapiens	131-161
26255711-10	2015	Poly(I:C) also induced activations of the mitogen-activated protein kinases (MAPKs), the nuclear factor-kappaB (NF-kappaB) and the interferon regulatory factor 3 (IRF3) pathways.	Poly I-C	0-8	interferon regulatory factor 3	Homo sapiens	163-167
26255711-11	2015	By using specific inhibitors, we found that poly(I:C)-induced expressions of MMP-1, -2, and -3 were differentially regulated by these signaling pathways.	Poly I-C	44-53	matrix metallopeptidase 1	Homo sapiens	77-94
26297761-2	2015	In this study, we examined the role of plasmacytoid dendritic cell (pDC) activation and IFN-alpha production in this disease as well as in a murine model of AIP (MRL/Mp mice treated with polyinosinic-polycytidylic acid).	Poly I-C	187-218	interferon alpha	Mus musculus	88-97
26817207-7	2015	All concentrations of genistein and 17beta-estradiol attenuated the poly I: C induced increase in the TLR2.	Poly I-C	68-77	toll like receptor 2	Homo sapiens	102-106
26817207-8	2015	By contrast, both genistein at 10(-5) M and 17 beta-estradiol further potentiated the TLR4 suppressed by poly I: C.	Poly I-C	105-114	toll like receptor 4	Homo sapiens	86-90
26414184-13	2015	The changes in morphology induced by Poly I:C were mediated by the toll-like receptor adaptor molecule 1 (Ticam1) in enteroids but not in colonoids.	Poly I-C	37-45	toll-like receptor adaptor molecule 1	Mus musculus	67-104
26418032-3	2015	In this study, we demonstrated that IL-17A and polyI:C, the ligand of TLR3, synergistically induced the expression of proinflammatory cytokines and chemokines (G-CSF, IL-8, CXCL1, CXCL5, IL-1F9), but not type I interferon (IFN-alpha1, -beta) in primary culture of normal human bronchial epithelial cells.	Poly I-C	47-54	toll like receptor 3	Homo sapiens	70-74
26418032-3	2015	In this study, we demonstrated that IL-17A and polyI:C, the ligand of TLR3, synergistically induced the expression of proinflammatory cytokines and chemokines (G-CSF, IL-8, CXCL1, CXCL5, IL-1F9), but not type I interferon (IFN-alpha1, -beta) in primary culture of normal human bronchial epithelial cells.	Poly I-C	47-54	colony stimulating factor 3	Homo sapiens	160-165
26418032-3	2015	In this study, we demonstrated that IL-17A and polyI:C, the ligand of TLR3, synergistically induced the expression of proinflammatory cytokines and chemokines (G-CSF, IL-8, CXCL1, CXCL5, IL-1F9), but not type I interferon (IFN-alpha1, -beta) in primary culture of normal human bronchial epithelial cells.	Poly I-C	47-54	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
26418032-3	2015	In this study, we demonstrated that IL-17A and polyI:C, the ligand of TLR3, synergistically induced the expression of proinflammatory cytokines and chemokines (G-CSF, IL-8, CXCL1, CXCL5, IL-1F9), but not type I interferon (IFN-alpha1, -beta) in primary culture of normal human bronchial epithelial cells.	Poly I-C	47-54	C-X-C motif chemokine ligand 1	Homo sapiens	173-178
26418032-3	2015	In this study, we demonstrated that IL-17A and polyI:C, the ligand of TLR3, synergistically induced the expression of proinflammatory cytokines and chemokines (G-CSF, IL-8, CXCL1, CXCL5, IL-1F9), but not type I interferon (IFN-alpha1, -beta) in primary culture of normal human bronchial epithelial cells.	Poly I-C	47-54	C-X-C motif chemokine ligand 5	Homo sapiens	180-185
26418032-3	2015	In this study, we demonstrated that IL-17A and polyI:C, the ligand of TLR3, synergistically induced the expression of proinflammatory cytokines and chemokines (G-CSF, IL-8, CXCL1, CXCL5, IL-1F9), but not type I interferon (IFN-alpha1, -beta) in primary culture of normal human bronchial epithelial cells.	Poly I-C	47-54	interleukin 36 gamma	Homo sapiens	187-193
26208481-2	2015	Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral RNA sensors, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) in the cytosolic compartment might also be implicated in poly(I:C)-induced NB cell death.	Poly I-C	62-71	interferon induced with helicase C domain 1	Homo sapiens	244-248
26208481-2	2015	Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral RNA sensors, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) in the cytosolic compartment might also be implicated in poly(I:C)-induced NB cell death.	Poly I-C	62-71	DExD/H-box helicase 58	Homo sapiens	254-284
26208481-2	2015	Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral RNA sensors, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) in the cytosolic compartment might also be implicated in poly(I:C)-induced NB cell death.	Poly I-C	62-71	DExD/H-box helicase 58	Homo sapiens	286-291
26208481-2	2015	Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral RNA sensors, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) in the cytosolic compartment might also be implicated in poly(I:C)-induced NB cell death.	Poly I-C	350-359	toll like receptor 3	Homo sapiens	15-19
26208481-5	2015	Over-expression of MDA5 in FaDu cells resulted in significantly less colony formation and more poly(I:C)-induced cell death.	Poly I-C	95-104	interferon induced with helicase C domain 1	Homo sapiens	19-23
26418032-7	2015	Comparing the levels of mRNA induction between co-treatment with IL-17A/polyI:C and treatment with polyI:C alone, blocking the of NF-kappaB pathway significantly attenuated the observed synergism.	Poly I-C	72-79	interleukin 17A	Homo sapiens	65-71
26418032-7	2015	Comparing the levels of mRNA induction between co-treatment with IL-17A/polyI:C and treatment with polyI:C alone, blocking the of NF-kappaB pathway significantly attenuated the observed synergism.	Poly I-C	99-106	interleukin 17A	Homo sapiens	65-71
26418032-8	2015	In western blotting analysis, activation of both NF-kappaB and IRF3 was observed in treatment with polyI:C and co-treatment with IL-17A/polyI:C; moreover, co-treatment with IL-17A/polyI:C augmented IkappaB-alpha phosphorylation as compared to polyI:C treatment alone.	Poly I-C	99-106	interferon regulatory factor 3	Homo sapiens	63-67
26418032-8	2015	In western blotting analysis, activation of both NF-kappaB and IRF3 was observed in treatment with polyI:C and co-treatment with IL-17A/polyI:C; moreover, co-treatment with IL-17A/polyI:C augmented IkappaB-alpha phosphorylation as compared to polyI:C treatment alone.	Poly I-C	99-106	interleukin 17A	Homo sapiens	173-179
26418032-8	2015	In western blotting analysis, activation of both NF-kappaB and IRF3 was observed in treatment with polyI:C and co-treatment with IL-17A/polyI:C; moreover, co-treatment with IL-17A/polyI:C augmented IkappaB-alpha phosphorylation as compared to polyI:C treatment alone.	Poly I-C	99-106	NFKB inhibitor alpha	Homo sapiens	198-211
26418032-8	2015	In western blotting analysis, activation of both NF-kappaB and IRF3 was observed in treatment with polyI:C and co-treatment with IL-17A/polyI:C; moreover, co-treatment with IL-17A/polyI:C augmented IkappaB-alpha phosphorylation as compared to polyI:C treatment alone.	Poly I-C	136-143	interferon regulatory factor 3	Homo sapiens	63-67
26418032-8	2015	In western blotting analysis, activation of both NF-kappaB and IRF3 was observed in treatment with polyI:C and co-treatment with IL-17A/polyI:C; moreover, co-treatment with IL-17A/polyI:C augmented IkappaB-alpha phosphorylation as compared to polyI:C treatment alone.	Poly I-C	136-143	interleukin 17A	Homo sapiens	129-135
26418032-8	2015	In western blotting analysis, activation of both NF-kappaB and IRF3 was observed in treatment with polyI:C and co-treatment with IL-17A/polyI:C; moreover, co-treatment with IL-17A/polyI:C augmented IkappaB-alpha phosphorylation as compared to polyI:C treatment alone.	Poly I-C	136-143	interleukin 17A	Homo sapiens	173-179
26418032-8	2015	In western blotting analysis, activation of both NF-kappaB and IRF3 was observed in treatment with polyI:C and co-treatment with IL-17A/polyI:C; moreover, co-treatment with IL-17A/polyI:C augmented IkappaB-alpha phosphorylation as compared to polyI:C treatment alone.	Poly I-C	136-143	NFKB inhibitor alpha	Homo sapiens	198-211
26418032-8	2015	In western blotting analysis, activation of both NF-kappaB and IRF3 was observed in treatment with polyI:C and co-treatment with IL-17A/polyI:C; moreover, co-treatment with IL-17A/polyI:C augmented IkappaB-alpha phosphorylation as compared to polyI:C treatment alone.	Poly I-C	136-143	interferon regulatory factor 3	Homo sapiens	63-67
26418032-8	2015	In western blotting analysis, activation of both NF-kappaB and IRF3 was observed in treatment with polyI:C and co-treatment with IL-17A/polyI:C; moreover, co-treatment with IL-17A/polyI:C augmented IkappaB-alpha phosphorylation as compared to polyI:C treatment alone.	Poly I-C	136-143	interleukin 17A	Homo sapiens	129-135
26418032-8	2015	In western blotting analysis, activation of both NF-kappaB and IRF3 was observed in treatment with polyI:C and co-treatment with IL-17A/polyI:C; moreover, co-treatment with IL-17A/polyI:C augmented IkappaB-alpha phosphorylation as compared to polyI:C treatment alone.	Poly I-C	136-143	interleukin 17A	Homo sapiens	173-179
26418032-8	2015	In western blotting analysis, activation of both NF-kappaB and IRF3 was observed in treatment with polyI:C and co-treatment with IL-17A/polyI:C; moreover, co-treatment with IL-17A/polyI:C augmented IkappaB-alpha phosphorylation as compared to polyI:C treatment alone.	Poly I-C	136-143	NFKB inhibitor alpha	Homo sapiens	198-211
26418032-9	2015	Collectively, these findings indicate that IL-17A and TLR3 activation cooperate to induce proinflammatory responses in the airway epithelium via TLR3/TRIF-mediated NF-kappaB/IRF3 activation, and that enhanced activation of the NF-kappaB pathway plays an essential role in synergistic induction after co-treatment with IL-17A and polyI:C in vitro.	Poly I-C	329-336	interleukin 17A	Homo sapiens	43-49
26418032-9	2015	Collectively, these findings indicate that IL-17A and TLR3 activation cooperate to induce proinflammatory responses in the airway epithelium via TLR3/TRIF-mediated NF-kappaB/IRF3 activation, and that enhanced activation of the NF-kappaB pathway plays an essential role in synergistic induction after co-treatment with IL-17A and polyI:C in vitro.	Poly I-C	329-336	toll like receptor 3	Homo sapiens	54-58
26418032-9	2015	Collectively, these findings indicate that IL-17A and TLR3 activation cooperate to induce proinflammatory responses in the airway epithelium via TLR3/TRIF-mediated NF-kappaB/IRF3 activation, and that enhanced activation of the NF-kappaB pathway plays an essential role in synergistic induction after co-treatment with IL-17A and polyI:C in vitro.	Poly I-C	329-336	TIR domain containing adaptor molecule 1	Homo sapiens	150-154
26208481-2	2015	Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral RNA sensors, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) in the cytosolic compartment might also be implicated in poly(I:C)-induced NB cell death.	Poly I-C	29-60	toll like receptor 3	Homo sapiens	15-19
26208481-2	2015	Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral RNA sensors, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) in the cytosolic compartment might also be implicated in poly(I:C)-induced NB cell death.	Poly I-C	29-60	toll like receptor 3	Homo sapiens	123-127
26208481-2	2015	Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral RNA sensors, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) in the cytosolic compartment might also be implicated in poly(I:C)-induced NB cell death.	Poly I-C	29-60	interferon induced with helicase C domain 1	Homo sapiens	200-242
26208481-2	2015	Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral RNA sensors, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) in the cytosolic compartment might also be implicated in poly(I:C)-induced NB cell death.	Poly I-C	29-60	interferon induced with helicase C domain 1	Homo sapiens	244-248
26208481-2	2015	Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral RNA sensors, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) in the cytosolic compartment might also be implicated in poly(I:C)-induced NB cell death.	Poly I-C	29-60	DExD/H-box helicase 58	Homo sapiens	254-284
26208481-2	2015	Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral RNA sensors, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) in the cytosolic compartment might also be implicated in poly(I:C)-induced NB cell death.	Poly I-C	29-60	DExD/H-box helicase 58	Homo sapiens	286-291
26208481-2	2015	Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral RNA sensors, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) in the cytosolic compartment might also be implicated in poly(I:C)-induced NB cell death.	Poly I-C	62-71	toll like receptor 3	Homo sapiens	15-19
26208481-2	2015	Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral RNA sensors, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) in the cytosolic compartment might also be implicated in poly(I:C)-induced NB cell death.	Poly I-C	62-71	toll like receptor 3	Homo sapiens	123-127
26208481-2	2015	Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral RNA sensors, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) in the cytosolic compartment might also be implicated in poly(I:C)-induced NB cell death.	Poly I-C	62-71	interferon induced with helicase C domain 1	Homo sapiens	200-242
26414184-13	2015	The changes in morphology induced by Poly I:C were mediated by the toll-like receptor adaptor molecule 1 (Ticam1) in enteroids but not in colonoids.	Poly I-C	37-45	toll-like receptor adaptor molecule 1	Mus musculus	106-112
26330750-8	2015	Poly(I:C) also induced phosphorylation of ERK1/2 and p38 MAPK proteins, and the secretion of bFGF and TNFalpha from the cells.	Poly I-C	0-8	mitogen-activated protein kinase 3	Homo sapiens	42-48
26283481-2	2015	Polyinosinic-polycytidylic acid [poly(I:C)] is a known inducer of IFN-beta but also costimulates an inflammatory response.	Poly I-C	0-31	interferon beta 1	Homo sapiens	66-74
26283481-2	2015	Polyinosinic-polycytidylic acid [poly(I:C)] is a known inducer of IFN-beta but also costimulates an inflammatory response.	Poly I-C	33-42	interferon beta 1	Homo sapiens	66-74
26283481-9	2015	In contrast, we show that stimulation of the RIG-I/MAVS pathway, such as when poly(I:C) is delivered intracellularly in a complex with liposomes or via nucleofection, selectively stimulates IFN-beta with low IL-8 costimulation.	Poly I-C	78-87	DExD/H-box helicase 58	Homo sapiens	45-50
26283481-9	2015	In contrast, we show that stimulation of the RIG-I/MAVS pathway, such as when poly(I:C) is delivered intracellularly in a complex with liposomes or via nucleofection, selectively stimulates IFN-beta with low IL-8 costimulation.	Poly I-C	78-87	mitochondrial antiviral signaling protein	Homo sapiens	51-55
26283481-9	2015	In contrast, we show that stimulation of the RIG-I/MAVS pathway, such as when poly(I:C) is delivered intracellularly in a complex with liposomes or via nucleofection, selectively stimulates IFN-beta with low IL-8 costimulation.	Poly I-C	78-87	interferon beta 1	Homo sapiens	190-198
26283481-9	2015	In contrast, we show that stimulation of the RIG-I/MAVS pathway, such as when poly(I:C) is delivered intracellularly in a complex with liposomes or via nucleofection, selectively stimulates IFN-beta with low IL-8 costimulation.	Poly I-C	78-87	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
26141411-4	2015	ECTV interfered with p65 NF-kappaB nuclear translocation induced by TLR ligands such as lipopolysaccharide (LPS) (TLR4), polyinosinic-polycytidylic acid (poly(I:C)) (TLR3) and diacylated lipopeptide Pam2CSK4 (TLR2/6).	Poly I-C	121-152	RELA proto-oncogene, NF-kB subunit	Homo sapiens	21-24
26330750-8	2015	Poly(I:C) also induced phosphorylation of ERK1/2 and p38 MAPK proteins, and the secretion of bFGF and TNFalpha from the cells.	Poly I-C	0-8	mitogen-activated protein kinase 1	Homo sapiens	53-56
26399532-9	2015	Poly(I:C) significantly induced the expression of splice variant 1 (V1) of porcine PILRA, but hardly affected the expression of V2 and V3.	Poly I-C	0-8	paired immunoglobulin-like type 2 receptor alpha	Sus scrofa	83-88
26330750-8	2015	Poly(I:C) also induced phosphorylation of ERK1/2 and p38 MAPK proteins, and the secretion of bFGF and TNFalpha from the cells.	Poly I-C	0-8	mitogen-activated protein kinase 3	Homo sapiens	57-61
26330750-8	2015	Poly(I:C) also induced phosphorylation of ERK1/2 and p38 MAPK proteins, and the secretion of bFGF and TNFalpha from the cells.	Poly I-C	0-8	fibroblast growth factor 2	Homo sapiens	93-97
26330750-8	2015	Poly(I:C) also induced phosphorylation of ERK1/2 and p38 MAPK proteins, and the secretion of bFGF and TNFalpha from the cells.	Poly I-C	0-8	tumor necrosis factor	Homo sapiens	102-110
26179904-4	2015	Similar to IL-1alpha, AS-IL1alpha is expressed at low levels in resting macrophages and is induced following infection with Listeria monocytogenes or stimulation with TLR ligands (Pam3CSK4, LPS, polyinosinic-polycytidylic acid).	Poly I-C	195-226	interleukin 1 alpha	Homo sapiens	25-33
25900439-3	2015	IFN-I receptor 1 deficient mice (IFNAR1(-/-)) displayed significantly attenuated poly I:C-induced hypothermia, hypoactivity and weight loss compared to WT C57BL/6 mice.	Poly I-C	81-89	interferon (alpha and beta) receptor 1	Mus musculus	33-39
25900439-5	2015	IFN-beta injection induced trivial IL-6 production and limited behavioural change and the poly I:C-induced IFN-beta response did not preceed, and would not appear to mediate, IL-6 induction.	Poly I-C	90-98	interferon beta 1, fibroblast	Mus musculus	107-115
26208484-1	2015	Polyinosinic-polycytidylic acid [Poly (I: C)], a ligand for Toll-like receptor (TLR-3), is used as an adjuvant to enhance anti-tumor immunity because of its prominent effects on CD8 T cells and NK cells.	Poly I-C	0-31	toll-like receptor 3	Mus musculus	80-85
25898986-0	2015	PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo.	Poly I-C	0-7	toll-like receptor 3	Mus musculus	17-21
25898986-0	2015	PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo.	Poly I-C	0-7	receptor-interacting serine-threonine kinase 3	Mus musculus	22-26
26208484-1	2015	Polyinosinic-polycytidylic acid [Poly (I: C)], a ligand for Toll-like receptor (TLR-3), is used as an adjuvant to enhance anti-tumor immunity because of its prominent effects on CD8 T cells and NK cells.	Poly I-C	33-44	toll-like receptor 3	Mus musculus	80-85
25480733-5	2015	Polyinosinic-polycytidylic acid [poly (I:C)] induced porcine S100A6 gene expression in PK-15 cells.	Poly I-C	0-31	S100 calcium binding protein A6	Sus scrofa	61-67
26350376-7	2015	polyinosinic-polycytidylic acid (Poly I:C) was employed to activate TLR3 on SSCs.	Poly I-C	0-31	toll-like receptor 3	Mus musculus	68-72
26350376-9	2015	Exposure to PolyI:C induced interferon regulatory factor 3 (IRF3) phosphorylation in SSCs.	Poly I-C	12-19	interferon regulatory factor 3	Mus musculus	28-58
26350376-9	2015	Exposure to PolyI:C induced interferon regulatory factor 3 (IRF3) phosphorylation in SSCs.	Poly I-C	12-19	interferon regulatory factor 3	Mus musculus	60-64
26350376-12	2015	In conclusion, the results of the present study indicate that activation of TLR3 by PolyI:C induces the SSC apoptosis, which implies that viral infection may interfere with the male germ cell development.	Poly I-C	84-91	toll-like receptor 3	Mus musculus	76-80
25480733-5	2015	Polyinosinic-polycytidylic acid [poly (I:C)] induced porcine S100A6 gene expression in PK-15 cells.	Poly I-C	33-43	S100 calcium binding protein A6	Sus scrofa	61-67
25747661-8	2015	During polyinosine-polycytidylic acid (Poly(I:C))-induced acute hepatitis, liver injury and hepatocyte-specific IL-33 expression was also inhibited by PJ34 without any protective effect of PJ34 in CCl4-induced liver injury.	Poly I-C	39-48	interleukin 33	Mus musculus	112-117
26101320-5	2015	We found that TLR3-ligand polyinosinic-polycytidylic acid and human rhinovirus infection induced a potent antiviral protection against Sendai and vesicular stomatitis virus in a TLR3 and type I IFN receptor-dependent manner.	Poly I-C	26-57	toll-like receptor 3	Mus musculus	14-18
26101320-5	2015	We found that TLR3-ligand polyinosinic-polycytidylic acid and human rhinovirus infection induced a potent antiviral protection against Sendai and vesicular stomatitis virus in a TLR3 and type I IFN receptor-dependent manner.	Poly I-C	26-57	toll-like receptor 3	Mus musculus	178-182
26043040-4	2015	Here we report that the maternal-fetal LIF signal relay in mice is suppressed by injection of polyriboinosinic-polyribocytidylic acid into dams, which induces MIA at 12.5 days post-coitum.	Poly I-C	94-133	leukemia inhibitory factor	Mus musculus	39-42
25869642-5	2015	Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells.	Poly I-C	70-101	interferon beta 1, fibroblast	Mus musculus	6-14
25869642-5	2015	Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells.	Poly I-C	70-101	interferon beta 1, fibroblast	Mus musculus	134-142
25869642-5	2015	Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells.	Poly I-C	70-101	interferon beta 1, fibroblast	Mus musculus	134-142
25869642-5	2015	Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells.	Poly I-C	70-101	protein tyrosine phosphatase, receptor type, C	Mus musculus	251-255
25869642-5	2015	Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells.	Poly I-C	70-101	integrin subunit alpha M	Homo sapiens	256-261
25869642-5	2015	Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells.	Poly I-C	70-101	interferon beta 1	Homo sapiens	134-142
25869642-5	2015	Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells.	Poly I-C	103-111	interferon beta 1, fibroblast	Mus musculus	6-14
25869642-5	2015	Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells.	Poly I-C	103-111	interferon beta 1, fibroblast	Mus musculus	134-142
25869642-5	2015	Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells.	Poly I-C	103-111	interferon beta 1, fibroblast	Mus musculus	134-142
25869642-5	2015	Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells.	Poly I-C	103-111	protein tyrosine phosphatase, receptor type, C	Mus musculus	251-255
25869642-5	2015	Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells.	Poly I-C	103-111	integrin subunit alpha M	Homo sapiens	256-261
25869642-5	2015	Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells.	Poly I-C	103-111	interferon beta 1	Homo sapiens	134-142
25869642-6	2015	Intrathecal injection of poly I:C to mice showing first symptoms of EAE substantially increased the normal disease-associated expression of IFN-alpha, IFN-beta, interferon regulatory factor-7 and IL-10 in CNS, and disease worsening was prevented for as long as IFN-alpha/beta was expressed.	Poly I-C	25-33	interferon alpha	Mus musculus	140-149
25869642-6	2015	Intrathecal injection of poly I:C to mice showing first symptoms of EAE substantially increased the normal disease-associated expression of IFN-alpha, IFN-beta, interferon regulatory factor-7 and IL-10 in CNS, and disease worsening was prevented for as long as IFN-alpha/beta was expressed.	Poly I-C	25-33	interferon beta 1, fibroblast	Mus musculus	151-159
25869642-6	2015	Intrathecal injection of poly I:C to mice showing first symptoms of EAE substantially increased the normal disease-associated expression of IFN-alpha, IFN-beta, interferon regulatory factor-7 and IL-10 in CNS, and disease worsening was prevented for as long as IFN-alpha/beta was expressed.	Poly I-C	25-33	interferon regulatory factor 7	Mus musculus	161-191
25869642-6	2015	Intrathecal injection of poly I:C to mice showing first symptoms of EAE substantially increased the normal disease-associated expression of IFN-alpha, IFN-beta, interferon regulatory factor-7 and IL-10 in CNS, and disease worsening was prevented for as long as IFN-alpha/beta was expressed.	Poly I-C	25-33	interleukin 10	Mus musculus	196-201
25869642-6	2015	Intrathecal injection of poly I:C to mice showing first symptoms of EAE substantially increased the normal disease-associated expression of IFN-alpha, IFN-beta, interferon regulatory factor-7 and IL-10 in CNS, and disease worsening was prevented for as long as IFN-alpha/beta was expressed.	Poly I-C	25-33	interferon alpha	Mus musculus	261-270
26040668-7	2015	We demonstrated that poly (I:C) induced TNFA production at a relatively high level in wild-type mice compared with that in Tlr3 knockout mice.	Poly I-C	21-30	tumor necrosis factor	Mus musculus	40-44
26040668-8	2015	Notably, TNFA neutralizing antibody significantly reduced poly (I:C)-induced ovarian dysfunction.	Poly I-C	58-68	tumor necrosis factor	Mus musculus	9-13
25735871-5	2015	By infection with SVCV, irf4a and irf4b were upregulated in both kidney and spleen, and were immediately induced by treatment with poly I:C in ZF4 cells.	Poly I-C	131-139	interferon regulatory factor 4a	Danio rerio	24-29
25735871-5	2015	By infection with SVCV, irf4a and irf4b were upregulated in both kidney and spleen, and were immediately induced by treatment with poly I:C in ZF4 cells.	Poly I-C	131-139	interferon regulatory factor 4b	Danio rerio	34-39
25796198-4	2015	Indeed, th reduced migration, greatly suppressed Src induction in both protein and RNA transcript by berberine were observed in macrophages exposed to LPS, peptidoglycan, polyinosinic-polycytidylic acid, and CpG-oligodeoxynucleotides.	Poly I-C	171-202	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	49-52
25797046-7	2015	Interestingly, the protein level of the APIM-containing PKR/RIG-1 activator protein (PACT) was initially strongly reduced in HaCaT cells stimulated with APIM-peptide in combination with the TLR ligand polyinosinic-polycytidylic acid (polyIC).	Poly I-C	201-232	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	56-59
25797046-7	2015	Interestingly, the protein level of the APIM-containing PKR/RIG-1 activator protein (PACT) was initially strongly reduced in HaCaT cells stimulated with APIM-peptide in combination with the TLR ligand polyinosinic-polycytidylic acid (polyIC).	Poly I-C	201-232	protein activator of interferon induced protein kinase EIF2AK2	Homo sapiens	85-89
25797046-7	2015	Interestingly, the protein level of the APIM-containing PKR/RIG-1 activator protein (PACT) was initially strongly reduced in HaCaT cells stimulated with APIM-peptide in combination with the TLR ligand polyinosinic-polycytidylic acid (polyIC).	Poly I-C	234-240	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	56-59
25797046-7	2015	Interestingly, the protein level of the APIM-containing PKR/RIG-1 activator protein (PACT) was initially strongly reduced in HaCaT cells stimulated with APIM-peptide in combination with the TLR ligand polyinosinic-polycytidylic acid (polyIC).	Poly I-C	234-240	protein activator of interferon induced protein kinase EIF2AK2	Homo sapiens	85-89
25887454-10	2015	Administration of poly(I:C) induced IFN-gamma plasma levels and downregulated the expression of several important ATP-binding cassette (ABC) drug efflux transporters in the placenta and liver of pregnant rats, compared with controls (P &lt; 0.05).	Poly I-C	18-26	interferon gamma	Rattus norvegicus	36-45
25903345-6	2015	Interestingly, CH25H is upregulated upon poly(I   C) treatment or HCV infection in hepatocytes, which triggers type I and III interferon responses, suggesting that the CH25H induction constitutes a part of host innate immune response.	Poly I-C	41-52	cholesterol 25-hydroxylase	Mus musculus	15-20
25903345-6	2015	Interestingly, CH25H is upregulated upon poly(I   C) treatment or HCV infection in hepatocytes, which triggers type I and III interferon responses, suggesting that the CH25H induction constitutes a part of host innate immune response.	Poly I-C	41-52	cholesterol 25-hydroxylase	Mus musculus	168-173
25903345-13	2015	Furthermore, we found that CH25H expression is upregulated upon poly(I C) stimulation or HCV infection, suggesting CH25H induction constitutes a part of host innate immune response.	Poly I-C	64-73	cholesterol 25-hydroxylase	Mus musculus	27-32
25903345-13	2015	Furthermore, we found that CH25H expression is upregulated upon poly(I C) stimulation or HCV infection, suggesting CH25H induction constitutes a part of host innate immune response.	Poly I-C	64-73	cholesterol 25-hydroxylase	Mus musculus	115-120
26100173-5	2015	RESULTS: CSE significantly potentiated the production of MUC5AC in epithelial cells stimulated with poly(I:C).	Poly I-C	100-108	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	57-63
26100173-6	2015	Antibodies to EGFR or EGFR ligands inhibited CSE-augmented MUC5AC release in poly(I:C)-treated cells.	Poly I-C	77-86	epidermal growth factor receptor	Homo sapiens	14-18
26100173-6	2015	Antibodies to EGFR or EGFR ligands inhibited CSE-augmented MUC5AC release in poly(I:C)-treated cells.	Poly I-C	77-86	epidermal growth factor receptor	Homo sapiens	22-26
26100173-6	2015	Antibodies to EGFR or EGFR ligands inhibited CSE-augmented MUC5AC release in poly(I:C)-treated cells.	Poly I-C	77-86	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	59-65
25912142-6	2015	PolyI:C was used as a ligand of TLR3.	Poly I-C	0-7	toll like receptor 3	Homo sapiens	32-36
25912142-8	2015	The results showed that exposure to PolyI:C markedly decreased the TER and increased the permeability of the HCE epithelial layers; the levels of cell junction protein, E-cadherin, were repressed by PolyI:C via increasing histone deacetylase-1 (HDAC1), the latter binding to the promoter of E-cadherin and repressed the transcription of E-cadherin.	Poly I-C	36-43	RNA guanylyltransferase and 5'-phosphatase	Homo sapiens	109-112
25912142-8	2015	The results showed that exposure to PolyI:C markedly decreased the TER and increased the permeability of the HCE epithelial layers; the levels of cell junction protein, E-cadherin, were repressed by PolyI:C via increasing histone deacetylase-1 (HDAC1), the latter binding to the promoter of E-cadherin and repressed the transcription of E-cadherin.	Poly I-C	36-43	cadherin 1	Homo sapiens	169-179
25912142-8	2015	The results showed that exposure to PolyI:C markedly decreased the TER and increased the permeability of the HCE epithelial layers; the levels of cell junction protein, E-cadherin, were repressed by PolyI:C via increasing histone deacetylase-1 (HDAC1), the latter binding to the promoter of E-cadherin and repressed the transcription of E-cadherin.	Poly I-C	36-43	histone deacetylase 1	Homo sapiens	222-250
25912142-8	2015	The results showed that exposure to PolyI:C markedly decreased the TER and increased the permeability of the HCE epithelial layers; the levels of cell junction protein, E-cadherin, were repressed by PolyI:C via increasing histone deacetylase-1 (HDAC1), the latter binding to the promoter of E-cadherin and repressed the transcription of E-cadherin.	Poly I-C	36-43	cadherin 1	Homo sapiens	291-301
25912142-8	2015	The results showed that exposure to PolyI:C markedly decreased the TER and increased the permeability of the HCE epithelial layers; the levels of cell junction protein, E-cadherin, were repressed by PolyI:C via increasing histone deacetylase-1 (HDAC1), the latter binding to the promoter of E-cadherin and repressed the transcription of E-cadherin.	Poly I-C	36-43	cadherin 1	Homo sapiens	291-301
25912142-8	2015	The results showed that exposure to PolyI:C markedly decreased the TER and increased the permeability of the HCE epithelial layers; the levels of cell junction protein, E-cadherin, were repressed by PolyI:C via increasing histone deacetylase-1 (HDAC1), the latter binding to the promoter of E-cadherin and repressed the transcription of E-cadherin.	Poly I-C	199-206	RNA guanylyltransferase and 5'-phosphatase	Homo sapiens	109-112
25912142-8	2015	The results showed that exposure to PolyI:C markedly decreased the TER and increased the permeability of the HCE epithelial layers; the levels of cell junction protein, E-cadherin, were repressed by PolyI:C via increasing histone deacetylase-1 (HDAC1), the latter binding to the promoter of E-cadherin and repressed the transcription of E-cadherin.	Poly I-C	199-206	cadherin 1	Homo sapiens	169-179
25912142-8	2015	The results showed that exposure to PolyI:C markedly decreased the TER and increased the permeability of the HCE epithelial layers; the levels of cell junction protein, E-cadherin, were repressed by PolyI:C via increasing histone deacetylase-1 (HDAC1), the latter binding to the promoter of E-cadherin and repressed the transcription of E-cadherin.	Poly I-C	199-206	histone deacetylase 1	Homo sapiens	222-250
25912142-8	2015	The results showed that exposure to PolyI:C markedly decreased the TER and increased the permeability of the HCE epithelial layers; the levels of cell junction protein, E-cadherin, were repressed by PolyI:C via increasing histone deacetylase-1 (HDAC1), the latter binding to the promoter of E-cadherin and repressed the transcription of E-cadherin.	Poly I-C	199-206	cadherin 1	Homo sapiens	291-301
25912142-8	2015	The results showed that exposure to PolyI:C markedly decreased the TER and increased the permeability of the HCE epithelial layers; the levels of cell junction protein, E-cadherin, were repressed by PolyI:C via increasing histone deacetylase-1 (HDAC1), the latter binding to the promoter of E-cadherin and repressed the transcription of E-cadherin.	Poly I-C	199-206	cadherin 1	Homo sapiens	291-301
25912142-9	2015	The addition of butyrate (an inhibitor of HDAC1) to the culture blocked the corneal epithelial barrier dysfunction caused by PolyI:C.	Poly I-C	125-132	histone deacetylase 1	Homo sapiens	42-47
25611696-7	2015	RESULTS: When PBMCs were stimulated with IFNalpha and polyinosinic-polycytidylic acid, IL28B induction was significantly lower in patients with IL28B-unfavorable genotype (rs12979860 CT/TT) than those with IL28B-favorable genotype (rs12979860 CC; P=0.049).	Poly I-C	54-85	interferon lambda 3	Homo sapiens	87-92
25963552-3	2015	We hypothesized that exposure to lipopolysaccharide (LPS, bacterial antigen) and polyinosinic-polycytidylic acid (poly(I:C), viral antigen) would decrease P-gp and BCRP in the human placenta.	Poly I-C	81-112	ATP binding cassette subfamily B member 1	Homo sapiens	155-159
25963552-3	2015	We hypothesized that exposure to lipopolysaccharide (LPS, bacterial antigen) and polyinosinic-polycytidylic acid (poly(I:C), viral antigen) would decrease P-gp and BCRP in the human placenta.	Poly I-C	81-112	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	164-168
25803620-5	2015	Both intracellular and extracellular poly(I:C) induced the expression of IFNB, TNF, IL6, and IL8.	Poly I-C	37-45	interleukin 6	Homo sapiens	84-87
25803620-5	2015	Both intracellular and extracellular poly(I:C) induced the expression of IFNB, TNF, IL6, and IL8.	Poly I-C	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
25803620-9	2015	Poly(I:C) treatment also induced the phosphorylation of p38 and JNK in melanocytes.	Poly I-C	0-8	mitogen-activated protein kinase 14	Homo sapiens	56-59
25803620-9	2015	Poly(I:C) treatment also induced the phosphorylation of p38 and JNK in melanocytes.	Poly I-C	0-8	mitogen-activated protein kinase 8	Homo sapiens	64-67
25803620-11	2015	However, only the JNK inhibitor decreased the intracellular poly(I:C)-induced melanocyte death.	Poly I-C	60-69	mitogen-activated protein kinase 8	Homo sapiens	18-21
25803620-4	2015	Intracellular poly(I:C)-induced melanocyte death was decreased by RIG-I or MDA5 siRNA, but not by TLR3 siRNA.	Poly I-C	14-23	DExD/H-box helicase 58	Homo sapiens	66-71
25803620-4	2015	Intracellular poly(I:C)-induced melanocyte death was decreased by RIG-I or MDA5 siRNA, but not by TLR3 siRNA.	Poly I-C	14-23	interferon induced with helicase C domain 1	Homo sapiens	75-79
25803620-5	2015	Both intracellular and extracellular poly(I:C) induced the expression of IFNB, TNF, IL6, and IL8.	Poly I-C	37-45	interferon beta 1	Homo sapiens	73-77
25803620-5	2015	Both intracellular and extracellular poly(I:C) induced the expression of IFNB, TNF, IL6, and IL8.	Poly I-C	37-45	tumor necrosis factor	Homo sapiens	79-82
25611696-7	2015	RESULTS: When PBMCs were stimulated with IFNalpha and polyinosinic-polycytidylic acid, IL28B induction was significantly lower in patients with IL28B-unfavorable genotype (rs12979860 CT/TT) than those with IL28B-favorable genotype (rs12979860 CC; P=0.049).	Poly I-C	54-85	interferon lambda 3	Homo sapiens	144-149
25611696-7	2015	RESULTS: When PBMCs were stimulated with IFNalpha and polyinosinic-polycytidylic acid, IL28B induction was significantly lower in patients with IL28B-unfavorable genotype (rs12979860 CT/TT) than those with IL28B-favorable genotype (rs12979860 CC; P=0.049).	Poly I-C	54-85	interferon lambda 3	Homo sapiens	144-149
25814471-6	2015	Using a human trophoblast cell culture system, we studied the effect of TLR-3 ligation on viperin expression by treating trophoblasts with polyinosinic-polycytidylic acid [Poly (I: C)] (a synthetic double-stranded RNA, which mimics viral RNA).	Poly I-C	172-183	toll like receptor 3	Homo sapiens	72-77
25917085-7	2015	Instead, challenge of TM with LPS or polyinosinic-polycytidylic acid induces MAPK, AP-1, and CREB signaling pathways, which leads to production of proinflammatory cytokines such as TNF-alpha, although at much lower levels than in peritoneal macrophages.	Poly I-C	37-68	mitogen-activated protein kinase 3	Homo sapiens	77-81
25917085-7	2015	Instead, challenge of TM with LPS or polyinosinic-polycytidylic acid induces MAPK, AP-1, and CREB signaling pathways, which leads to production of proinflammatory cytokines such as TNF-alpha, although at much lower levels than in peritoneal macrophages.	Poly I-C	37-68	cAMP responsive element binding protein 1	Homo sapiens	93-97
25917085-7	2015	Instead, challenge of TM with LPS or polyinosinic-polycytidylic acid induces MAPK, AP-1, and CREB signaling pathways, which leads to production of proinflammatory cytokines such as TNF-alpha, although at much lower levels than in peritoneal macrophages.	Poly I-C	37-68	tumor necrosis factor	Homo sapiens	181-190
25814471-6	2015	Using a human trophoblast cell culture system, we studied the effect of TLR-3 ligation on viperin expression by treating trophoblasts with polyinosinic-polycytidylic acid [Poly (I: C)] (a synthetic double-stranded RNA, which mimics viral RNA).	Poly I-C	139-170	toll like receptor 3	Homo sapiens	72-77
26191223-6	2015	PE significantly inhibited poly (I:C)-induced expression of crucial psoriatic cytokines, such as IL-6, IL-8, CCL20 and TNF-alpha, via down-regulation of NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	27-37	interleukin 6	Homo sapiens	97-101
25814471-6	2015	Using a human trophoblast cell culture system, we studied the effect of TLR-3 ligation on viperin expression by treating trophoblasts with polyinosinic-polycytidylic acid [Poly (I: C)] (a synthetic double-stranded RNA, which mimics viral RNA).	Poly I-C	139-170	radical S-adenosyl methionine domain containing 2	Homo sapiens	90-97
25814471-6	2015	Using a human trophoblast cell culture system, we studied the effect of TLR-3 ligation on viperin expression by treating trophoblasts with polyinosinic-polycytidylic acid [Poly (I: C)] (a synthetic double-stranded RNA, which mimics viral RNA).	Poly I-C	172-183	radical S-adenosyl methionine domain containing 2	Homo sapiens	90-97
25814471-10	2015	Poly (I: C) induced viperin expression in a dosage and time-dependent manner.	Poly I-C	0-10	radical S-adenosyl methionine domain containing 2	Homo sapiens	20-27
25840915-5	2015	TLR3 and retinoic acid-inducible gene I in EECs can be activated by their common agonist, polyinosinic-polycytidylic acid [poly(I:C)].	Poly I-C	90-121	toll-like receptor 3	Mus musculus	0-4
25840915-5	2015	TLR3 and retinoic acid-inducible gene I in EECs can be activated by their common agonist, polyinosinic-polycytidylic acid [poly(I:C)].	Poly I-C	90-121	DEAD/H box helicase 58	Mus musculus	9-39
25840915-8	2015	Poly(I:C), but not HSV60, also dramatically induced the expression of major proinflammatory cytokines, including TNF-alpha and MCP-1, in EECs.	Poly I-C	0-8	tumor necrosis factor	Mus musculus	113-122
25840915-8	2015	Poly(I:C), but not HSV60, also dramatically induced the expression of major proinflammatory cytokines, including TNF-alpha and MCP-1, in EECs.	Poly I-C	0-8	mast cell protease 1	Mus musculus	127-132
25559144-2	2015	Tumor necrosis factor (TNF)-alpha may promote the survival of poly(I:C)-stimulated DCs, but it is not known in detail how this combination affects the maturation and polarization capacity of monocyte-derived (Mo)DCs.	Poly I-C	62-71	tumor necrosis factor	Homo sapiens	0-33
25559144-4	2015	However, TNF-alpha also decreased poly(I:C)-induced production of interleukin (IL)-12 and IL-23 by MoDCs, which correlated with their diminished capacity to stimulate cellular proliferation, interferon-gamma and IL-17 production by allogeneic CD4(+)T cells in co-culture.	Poly I-C	34-43	tumor necrosis factor	Homo sapiens	9-18
25559144-4	2015	However, TNF-alpha also decreased poly(I:C)-induced production of interleukin (IL)-12 and IL-23 by MoDCs, which correlated with their diminished capacity to stimulate cellular proliferation, interferon-gamma and IL-17 production by allogeneic CD4(+)T cells in co-culture.	Poly I-C	34-43	interferon gamma	Homo sapiens	191-207
25559144-4	2015	However, TNF-alpha also decreased poly(I:C)-induced production of interleukin (IL)-12 and IL-23 by MoDCs, which correlated with their diminished capacity to stimulate cellular proliferation, interferon-gamma and IL-17 production by allogeneic CD4(+)T cells in co-culture.	Poly I-C	34-43	interleukin 17A	Homo sapiens	212-217
25576824-7	2015	Moreover, salmon UNC93B1 mRNA transcripts were up-regulated in vivo in spleen tissue from polyI:C treated salmon and in vitro in polyI:C or IFNgamma stimulated Salmon Head Kidney-1 (SHK-1) cells.	Poly I-C	90-97	unc-93 homolog B1, TLR signaling regulator	Homo sapiens	17-24
25576824-7	2015	Moreover, salmon UNC93B1 mRNA transcripts were up-regulated in vivo in spleen tissue from polyI:C treated salmon and in vitro in polyI:C or IFNgamma stimulated Salmon Head Kidney-1 (SHK-1) cells.	Poly I-C	129-136	unc-93 homolog B1, TLR signaling regulator	Homo sapiens	17-24
25950701-9	2015	RAG1-deficient mice given poly I:C exhibited increased frequency of TNF-alpha but not IFN-gamma/IL17A-producing ILCs in the gut and depletion of ILCs prevented the poly I:C-driven intestinal damage.	Poly I-C	26-34	tumor necrosis factor	Mus musculus	68-77
25950701-11	2015	Moreover, ILCs express TLR3 and are functionally able to respond to poly I:C with increased synthesis of TNF-alpha thus contributing to small intestinal atrophy.	Poly I-C	68-76	tumor necrosis factor	Mus musculus	105-114
25616220-9	2015	Importantly, BDCA3(+) cells, but not BDCA3(-) cells, in this system produced high IFN-lambda levels upon polyinosinic:polycytidylic acid (polyI:C) stimulation.	Poly I-C	105-136	thrombomodulin	Homo sapiens	13-18
25616220-9	2015	Importantly, BDCA3(+) cells, but not BDCA3(-) cells, in this system produced high IFN-lambda levels upon polyinosinic:polycytidylic acid (polyI:C) stimulation.	Poly I-C	105-136	interferon alpha 1	Homo sapiens	82-85
25616220-9	2015	Importantly, BDCA3(+) cells, but not BDCA3(-) cells, in this system produced high IFN-lambda levels upon polyinosinic:polycytidylic acid (polyI:C) stimulation.	Poly I-C	138-145	thrombomodulin	Homo sapiens	13-18
25616220-9	2015	Importantly, BDCA3(+) cells, but not BDCA3(-) cells, in this system produced high IFN-lambda levels upon polyinosinic:polycytidylic acid (polyI:C) stimulation.	Poly I-C	138-145	interferon alpha 1	Homo sapiens	82-85
26191223-6	2015	PE significantly inhibited poly (I:C)-induced expression of crucial psoriatic cytokines, such as IL-6, IL-8, CCL20 and TNF-alpha, via down-regulation of NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
26191223-6	2015	PE significantly inhibited poly (I:C)-induced expression of crucial psoriatic cytokines, such as IL-6, IL-8, CCL20 and TNF-alpha, via down-regulation of NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	27-37	C-C motif chemokine ligand 20	Homo sapiens	109-114
26191223-6	2015	PE significantly inhibited poly (I:C)-induced expression of crucial psoriatic cytokines, such as IL-6, IL-8, CCL20 and TNF-alpha, via down-regulation of NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	27-37	tumor necrosis factor	Homo sapiens	119-128
25406959-6	2015	Substantial reductions of ISGylation were observed in Herc6-deficient cells after polyinosinic-polycytidylic acid double-stranded RNA injection of mice or IFN treatment of cells.	Poly I-C	82-113	hect domain and RLD 6	Mus musculus	54-59
25843256-7	2015	FBP significantly attenuated ICAM-1 expression and NF-kappaB activity induced by poly[I:C] or overexpression of TRIF or TBK1.	Poly I-C	81-89	fructose-bisphosphatase 1	Homo sapiens	0-3
25849666-0	2015	Engagement of Fas on Macrophages Modulates Poly I:C induced cytokine production with specific enhancement of IP-10.	Poly I-C	43-51	C-X-C motif chemokine ligand 10	Homo sapiens	109-114
25843256-7	2015	FBP significantly attenuated ICAM-1 expression and NF-kappaB activity induced by poly[I:C] or overexpression of TRIF or TBK1.	Poly I-C	81-89	intercellular adhesion molecule 1	Homo sapiens	29-35
25680291-7	2015	Furthermore, IFN-beta was induced by polyI:C and VSV in both bat and mouse cells.	Poly I-C	37-44	interferon beta 1	Homo sapiens	13-21
25682934-8	2015	TRIM25 expression was also significantly upregulated in chicken embryo fibroblasts upon stimulation with poly(I:C) or poly(dA:dT).	Poly I-C	105-114	tripartite motif containing 25	Gallus gallus	0-6
25873314-0	2015	Potential effects of interferon regulatory factor 4 in a murine model of polyinosinic-polycytidylic acid-induced embryo resorption.	Poly I-C	73-104	interferon regulatory factor 4	Mus musculus	21-51
25873314-2	2015	Polyinosinic-polycytidylic acid (poly(I:C)) can be specifically recognised by TLR3, triggering the innate immune response and subsequently resulting in pregnancy loss.	Poly I-C	0-31	toll-like receptor 3	Mus musculus	78-82
25873314-6	2015	IRF4 mRNA and protein levels and T helper (Th) 17 cell frequencies in the poly(I:C)-treated group were significantly higher than in the phosphate-buffered saline (PBS)-treated control group, and were correlated with a significantly higher embryo resorption rate.	Poly I-C	74-83	interferon regulatory factor 4	Mus musculus	0-4
25591911-0	2015	Desferrioxamine, an iron chelator, inhibits CXCL10 expression induced by polyinosinic-polycytidylic acid in U373MG human astrocytoma cells.	Poly I-C	73-104	C-X-C motif chemokine ligand 10	Homo sapiens	44-50
25591911-3	2015	In the present study, pretreatment of U373MG human astrocytoma cells with an iron chelator desferrioxamine (DFX) inhibited the expression of CXCL10 induced by a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC).	Poly I-C	197-228	C-X-C motif chemokine ligand 10	Homo sapiens	141-147
25591911-3	2015	In the present study, pretreatment of U373MG human astrocytoma cells with an iron chelator desferrioxamine (DFX) inhibited the expression of CXCL10 induced by a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC).	Poly I-C	197-228	toll like receptor 3	Homo sapiens	161-181
25591911-3	2015	In the present study, pretreatment of U373MG human astrocytoma cells with an iron chelator desferrioxamine (DFX) inhibited the expression of CXCL10 induced by a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC).	Poly I-C	197-228	toll like receptor 3	Homo sapiens	183-187
25927603-4	2015	The TLR4 agonist lipopolysaccharide (LPS) and the TLR3 agonist polyinosinic-polycytidylic acid (Poly I:C) induce an increase in microglial CLM-1 mRNA levels in vitro, whereas the TLR2/6 heterodimer agonist peptidoglycan (PGN) produces a marked decrease.	Poly I-C	63-94	toll-like receptor 3	Mus musculus	50-54
25927603-4	2015	The TLR4 agonist lipopolysaccharide (LPS) and the TLR3 agonist polyinosinic-polycytidylic acid (Poly I:C) induce an increase in microglial CLM-1 mRNA levels in vitro, whereas the TLR2/6 heterodimer agonist peptidoglycan (PGN) produces a marked decrease.	Poly I-C	63-94	CD300 molecule like family member F	Mus musculus	139-144
25927603-4	2015	The TLR4 agonist lipopolysaccharide (LPS) and the TLR3 agonist polyinosinic-polycytidylic acid (Poly I:C) induce an increase in microglial CLM-1 mRNA levels in vitro, whereas the TLR2/6 heterodimer agonist peptidoglycan (PGN) produces a marked decrease.	Poly I-C	63-94	toll-like receptor 2	Mus musculus	179-185
25927603-4	2015	The TLR4 agonist lipopolysaccharide (LPS) and the TLR3 agonist polyinosinic-polycytidylic acid (Poly I:C) induce an increase in microglial CLM-1 mRNA levels in vitro, whereas the TLR2/6 heterodimer agonist peptidoglycan (PGN) produces a marked decrease.	Poly I-C	96-104	toll-like receptor 4	Mus musculus	4-8
25927603-4	2015	The TLR4 agonist lipopolysaccharide (LPS) and the TLR3 agonist polyinosinic-polycytidylic acid (Poly I:C) induce an increase in microglial CLM-1 mRNA levels in vitro, whereas the TLR2/6 heterodimer agonist peptidoglycan (PGN) produces a marked decrease.	Poly I-C	96-104	toll-like receptor 3	Mus musculus	50-54
25927603-4	2015	The TLR4 agonist lipopolysaccharide (LPS) and the TLR3 agonist polyinosinic-polycytidylic acid (Poly I:C) induce an increase in microglial CLM-1 mRNA levels in vitro, whereas the TLR2/6 heterodimer agonist peptidoglycan (PGN) produces a marked decrease.	Poly I-C	96-104	CD300 molecule like family member F	Mus musculus	139-144
25927603-4	2015	The TLR4 agonist lipopolysaccharide (LPS) and the TLR3 agonist polyinosinic-polycytidylic acid (Poly I:C) induce an increase in microglial CLM-1 mRNA levels in vitro, whereas the TLR2/6 heterodimer agonist peptidoglycan (PGN) produces a marked decrease.	Poly I-C	96-104	toll-like receptor 2	Mus musculus	179-185
25849666-6	2015	In particular, poly I:C-induced IP-10 production was significantly enhanced.	Poly I-C	15-23	C-X-C motif chemokine ligand 10	Homo sapiens	32-37
25849666-8	2015	Fas activation suppressed poly I:C-induced phosphorylation of the MAP kinases p38 and JNK, while overexpression of the Fas adaptor protein, Fas-associated protein with death domain (FADD), activated AP-1 and inhibited poly I:C-induced IP-10 production.	Poly I-C	26-34	mitogen-activated protein kinase 14	Homo sapiens	78-81
25849666-8	2015	Fas activation suppressed poly I:C-induced phosphorylation of the MAP kinases p38 and JNK, while overexpression of the Fas adaptor protein, Fas-associated protein with death domain (FADD), activated AP-1 and inhibited poly I:C-induced IP-10 production.	Poly I-C	26-34	mitogen-activated protein kinase 8	Homo sapiens	86-89
25849666-8	2015	Fas activation suppressed poly I:C-induced phosphorylation of the MAP kinases p38 and JNK, while overexpression of the Fas adaptor protein, Fas-associated protein with death domain (FADD), activated AP-1 and inhibited poly I:C-induced IP-10 production.	Poly I-C	26-34	Fas associated via death domain	Homo sapiens	182-186
25849666-8	2015	Fas activation suppressed poly I:C-induced phosphorylation of the MAP kinases p38 and JNK, while overexpression of the Fas adaptor protein, Fas-associated protein with death domain (FADD), activated AP-1 and inhibited poly I:C-induced IP-10 production.	Poly I-C	26-34	C-X-C motif chemokine ligand 10	Homo sapiens	235-240
25849666-8	2015	Fas activation suppressed poly I:C-induced phosphorylation of the MAP kinases p38 and JNK, while overexpression of the Fas adaptor protein, Fas-associated protein with death domain (FADD), activated AP-1 and inhibited poly I:C-induced IP-10 production.	Poly I-C	218-226	mitogen-activated protein kinase 14	Homo sapiens	78-81
25849666-8	2015	Fas activation suppressed poly I:C-induced phosphorylation of the MAP kinases p38 and JNK, while overexpression of the Fas adaptor protein, Fas-associated protein with death domain (FADD), activated AP-1 and inhibited poly I:C-induced IP-10 production.	Poly I-C	218-226	Fas associated via death domain	Homo sapiens	182-186
25849666-9	2015	Consistent with an inhibitory role for AP-1 in IP-10 production, mutation of the AP-1 binding site on the IP-10 promoter resulted in augmented poly I:C-induced IP-10.	Poly I-C	143-151	C-X-C motif chemokine ligand 10	Homo sapiens	47-52
25849666-9	2015	Consistent with an inhibitory role for AP-1 in IP-10 production, mutation of the AP-1 binding site on the IP-10 promoter resulted in augmented poly I:C-induced IP-10.	Poly I-C	143-151	C-X-C motif chemokine ligand 10	Homo sapiens	106-111
25849666-9	2015	Consistent with an inhibitory role for AP-1 in IP-10 production, mutation of the AP-1 binding site on the IP-10 promoter resulted in augmented poly I:C-induced IP-10.	Poly I-C	143-151	C-X-C motif chemokine ligand 10	Homo sapiens	106-111
25838100-0	2015	Synergistic suppression of Poly(I:C)-induced CCL3 by a corticosteroid and a long acting beta2 agonist in nasal epithelial cells.	Poly I-C	27-36	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	88-93
25532794-7	2015	In primary nasal epithelium, poly(I:C) challenge results in an up-regulation of the TLR-1, TLR-2, and TLR-3 genes and reduction of expression of TLR-5.	Poly I-C	29-38	toll like receptor 1	Homo sapiens	84-89
25838100-0	2015	Synergistic suppression of Poly(I:C)-induced CCL3 by a corticosteroid and a long acting beta2 agonist in nasal epithelial cells.	Poly I-C	27-36	C-C motif chemokine ligand 3	Homo sapiens	45-49
25532794-7	2015	In primary nasal epithelium, poly(I:C) challenge results in an up-regulation of the TLR-1, TLR-2, and TLR-3 genes and reduction of expression of TLR-5.	Poly I-C	29-38	toll like receptor 2	Homo sapiens	91-96
25532794-7	2015	In primary nasal epithelium, poly(I:C) challenge results in an up-regulation of the TLR-1, TLR-2, and TLR-3 genes and reduction of expression of TLR-5.	Poly I-C	29-38	toll like receptor 3	Homo sapiens	102-107
25532794-7	2015	In primary nasal epithelium, poly(I:C) challenge results in an up-regulation of the TLR-1, TLR-2, and TLR-3 genes and reduction of expression of TLR-5.	Poly I-C	29-38	toll like receptor 5	Homo sapiens	145-150
25532794-8	2015	Poly(I:C) induced activation of TLR-2 contributes to stronger cell responses to a TLR-2 agonist and regulation of these synergistic responses may take place at the mRNA level of IL-6 and IL-8.	Poly I-C	0-8	toll like receptor 2	Homo sapiens	32-37
25532794-8	2015	Poly(I:C) induced activation of TLR-2 contributes to stronger cell responses to a TLR-2 agonist and regulation of these synergistic responses may take place at the mRNA level of IL-6 and IL-8.	Poly I-C	0-8	toll like receptor 2	Homo sapiens	82-87
25532794-8	2015	Poly(I:C) induced activation of TLR-2 contributes to stronger cell responses to a TLR-2 agonist and regulation of these synergistic responses may take place at the mRNA level of IL-6 and IL-8.	Poly I-C	0-8	interleukin 6	Homo sapiens	178-182
25532794-8	2015	Poly(I:C) induced activation of TLR-2 contributes to stronger cell responses to a TLR-2 agonist and regulation of these synergistic responses may take place at the mRNA level of IL-6 and IL-8.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
25605704-5	2015	STUDY DESIGN, SIZE, DURATION: Poly I:C was used as a TLR 3-specific ligand and endometrial cells were either treated or not with Poly I:C (treated versus control) in vitro.	Poly I-C	30-38	toll like receptor 3	Homo sapiens	53-58
25712217-4	2015	In this study, we demonstrate that productive HSV-2 infection suppresses Sendai virus (SeV) or polyinosinic-polycytidylic acid-induced IFN-beta production.	Poly I-C	95-126	interferon beta 1	Homo sapiens	135-143
25605704-13	2015	MAIN RESULTS AND THE ROLE OF CHANCE: We observed that stimulation of TLR 3 in endometrial cells with different concentrations of Poly I:C led to a reduction in the percentage of trophoblasts attached to the endometrial cells in a dose-dependent manner (P &lt; 0.05).	Poly I-C	129-137	toll like receptor 3	Homo sapiens	69-74
25792598-7	2015	These actions of CARM1 work together synergistically to regulate the export of transcripts containing IRAlus from paraspeckles under certain cellular stresses, such as poly(I:C) treatment.	Poly I-C	168-177	coactivator associated arginine methyltransferase 1	Homo sapiens	17-22
25664598-2	2015	Our previous study showed that MBL serves as a double-stranded RNA binding protein that attenuates polyriboinosinic-polyribocytidylic acid-induced TLR3 activation.	Poly I-C	99-138	mannose binding lectin 2	Homo sapiens	31-34
25664598-2	2015	Our previous study showed that MBL serves as a double-stranded RNA binding protein that attenuates polyriboinosinic-polyribocytidylic acid-induced TLR3 activation.	Poly I-C	99-138	toll like receptor 3	Homo sapiens	147-151
25637945-5	2015	Moreover, treatment of macrophages with other TLR ligands (eg, polyI:C or peptidoglycan) also induced Sesn2 expression.	Poly I-C	63-70	sestrin 2	Mus musculus	102-107
25659754-3	2015	This compound also inhibited TNF-alpha production following poly I:C stimulation of human monocytes and monocyte-derived dendritic cells; in the latter case, inhibition of IL-12 production was also observed.	Poly I-C	60-68	tumor necrosis factor	Homo sapiens	29-38
25798067-7	2015	Treatment with poly(I:C) increased the production of bone morphogenetic protein-2 (BMP-2), transforming growth factor beta-1 (TGF-beta1) and alkaline phosphatase (ALP), and resulted in calcium deposit formation.	Poly I-C	15-24	bone morphogenetic protein 2	Homo sapiens	53-81
25798067-7	2015	Treatment with poly(I:C) increased the production of bone morphogenetic protein-2 (BMP-2), transforming growth factor beta-1 (TGF-beta1) and alkaline phosphatase (ALP), and resulted in calcium deposit formation.	Poly I-C	15-24	bone morphogenetic protein 2	Homo sapiens	83-88
25798067-7	2015	Treatment with poly(I:C) increased the production of bone morphogenetic protein-2 (BMP-2), transforming growth factor beta-1 (TGF-beta1) and alkaline phosphatase (ALP), and resulted in calcium deposit formation.	Poly I-C	15-24	transforming growth factor beta 1	Homo sapiens	91-124
25798067-7	2015	Treatment with poly(I:C) increased the production of bone morphogenetic protein-2 (BMP-2), transforming growth factor beta-1 (TGF-beta1) and alkaline phosphatase (ALP), and resulted in calcium deposit formation.	Poly I-C	15-24	transforming growth factor beta 1	Homo sapiens	126-135
25798067-7	2015	Treatment with poly(I:C) increased the production of bone morphogenetic protein-2 (BMP-2), transforming growth factor beta-1 (TGF-beta1) and alkaline phosphatase (ALP), and resulted in calcium deposit formation.	Poly I-C	15-24	alkaline phosphatase, placental	Homo sapiens	141-161
25798067-7	2015	Treatment with poly(I:C) increased the production of bone morphogenetic protein-2 (BMP-2), transforming growth factor beta-1 (TGF-beta1) and alkaline phosphatase (ALP), and resulted in calcium deposit formation.	Poly I-C	15-24	alkaline phosphatase, placental	Homo sapiens	163-166
25798067-8	2015	Poly(I:C) induced the phosphorylation of NF-kappaB and ERK1/2.	Poly I-C	0-8	mitogen-activated protein kinase 3	Homo sapiens	55-61
25445065-7	2015	Protein analysis using multiplex assays and ELISA showed that polyI:C significantly increased maternal serum concentrations of interleukin-1beta, tumor necrosis factor, and CXCL1 3h after administration.	Poly I-C	62-69	interleukin 1 beta	Rattus norvegicus	127-144
25445065-12	2015	These results suggest that while polyI:C treatment significantly increases maternal CXCL1, elevations of this chemokine are not solely responsible for the effects of polyI:C on the behavior of the offspring.	Poly I-C	33-40	C-X-C motif chemokine ligand 1	Rattus norvegicus	84-89
25756182-7	2015	Type I IFN signaling was required for generating sIL-15 complexes as in vivo induction of sIL-15 complexes by Poly I:C stimulation or total body irradiation (TBI) was impaired in IFNAR-/- mice.	Poly I-C	110-118	interferon (alpha and beta) receptor 1	Mus musculus	179-184
25445065-7	2015	Protein analysis using multiplex assays and ELISA showed that polyI:C significantly increased maternal serum concentrations of interleukin-1beta, tumor necrosis factor, and CXCL1 3h after administration.	Poly I-C	62-69	C-X-C motif chemokine ligand 1	Rattus norvegicus	173-178
25585356-7	2015	Lyn activation, as determined by phosphorylation of Tyr396 residue, was observed upon short poly I:C stimulation in the mitochondria of macrophages.	Poly I-C	92-100	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
25585356-8	2015	Short poly I:C induced the formation of speckle-like aggregates of Lyn, which are prominent in mitochondria.	Poly I-C	6-14	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	67-70
25582076-0	2015	Poly I:C enhances production of nitric oxide in response to interferon-gamma via upregulation of interferon regulatory factor 7 in vascular endothelial cells.	Poly I-C	0-8	interferon gamma	Mus musculus	60-76
25351293-0	2015	Poly (I:C) therapy decreases cerebral ischaemia/reperfusion injury via TLR3-mediated prevention of Fas/FADD interaction.	Poly I-C	0-9	toll-like receptor 3	Mus musculus	71-75
25351293-0	2015	Poly (I:C) therapy decreases cerebral ischaemia/reperfusion injury via TLR3-mediated prevention of Fas/FADD interaction.	Poly I-C	0-9	Fas (TNFRSF6)-associated via death domain	Mus musculus	103-107
25351293-9	2015	However, Poly (I:C)-induced protection was lost in TLR3 knockout mice.	Poly I-C	9-19	toll-like receptor 3	Mus musculus	51-55
25351293-11	2015	Poly (I:C) treatment induced IRF3 phosphorylation, but it inhibited NF-kappaB activation in the brain.	Poly I-C	0-9	interferon regulatory factor 3	Mus musculus	29-33
25351293-13	2015	In addition, Poly (I:C) treatment decreased microglial cell caspase-3 activity.	Poly I-C	13-23	caspase 3	Mus musculus	60-69
25377467-6	2015	Subsequently, it was confirmed that this miR-122 sponge function of HCV RNA repressed the expression of polyinosinic-polycytidylic acid-stimulated type I interferons.	Poly I-C	104-135	microRNA 122	Homo sapiens	41-48
25582076-0	2015	Poly I:C enhances production of nitric oxide in response to interferon-gamma via upregulation of interferon regulatory factor 7 in vascular endothelial cells.	Poly I-C	0-8	interferon regulatory factor 7	Mus musculus	97-127
25582076-2	2015	Poly I:C augmented IFN-gamma-induced NO production although it alone did not induce the NO production.	Poly I-C	0-8	interferon gamma	Mus musculus	19-28
25582076-3	2015	Poly I:C augmented the NO production via enhanced expression of an inducible NO synthase protein.	Poly I-C	0-8	nitric oxide synthase 2, inducible	Mus musculus	67-88
25582076-7	2015	Therefore, poly I:C was suggested to augment IFN-gamma-induced NO production at the transcriptional level via enhanced IRF7 activation.	Poly I-C	11-19	interferon gamma	Mus musculus	45-54
25582076-7	2015	Therefore, poly I:C was suggested to augment IFN-gamma-induced NO production at the transcriptional level via enhanced IRF7 activation.	Poly I-C	11-19	interferon regulatory factor 7	Mus musculus	119-123
25568326-5	2015	By using genetic inhibition of different poly(I:C) receptors, we demonstrate the crucial role of TLR3 and Src in in-poly(I:C)-induced apoptosis.	Poly I-C	41-50	toll like receptor 3	Homo sapiens	97-101
25568326-5	2015	By using genetic inhibition of different poly(I:C) receptors, we demonstrate the crucial role of TLR3 and Src in in-poly(I:C)-induced apoptosis.	Poly I-C	41-50	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	106-109
25652132-8	2015	The TLR3 agonist poly I:C 10 mug/mL increased the IL-8 release in HBECs that was poorly inhibited by dexamethasone in smokers (24.5%) and smokers with COPD (21.6%).	Poly I-C	17-25	toll like receptor 3	Homo sapiens	4-8
25652132-8	2015	The TLR3 agonist poly I:C 10 mug/mL increased the IL-8 release in HBECs that was poorly inhibited by dexamethasone in smokers (24.5%) and smokers with COPD (21.6%).	Poly I-C	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	50-54