PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2906023-4	1988	At 24 hr following the last day of exposure to HCP, the activities of the three neuron specific enzymes, glutamic acid decarboxylase, tyrosine hydroxylase, and choline acetyltransferase, in rat brain were unchanged from those of the vehicle-treated control group.	Hexachlorophene	47-50	tyrosine hydroxylase	Rattus norvegicus	134-154
2906023-4	1988	At 24 hr following the last day of exposure to HCP, the activities of the three neuron specific enzymes, glutamic acid decarboxylase, tyrosine hydroxylase, and choline acetyltransferase, in rat brain were unchanged from those of the vehicle-treated control group.	Hexachlorophene	47-50	choline O-acetyltransferase	Rattus norvegicus	160-185
2906023-5	1988	Of the two astroglial enzyme markers measured, a small but significant increase was observed in the activity of nonneuronal enolase in the cerebellum and glutamine synthetase in the hippocampus of HCP-treated rats.	Hexachlorophene	197-200	glutamate-ammonia ligase	Rattus norvegicus	154-174
1137505-1	1975	Young rats 6 to 22 days of age are extremely susceptible to the neurotoxic effects of hexachlorophene given as a daily bath of undiluted antiseptic detergent containing 3% hexachlorophene (pHiso-Hex).	Hexachlorophene	86-101	hematopoietically expressed homeobox	Rattus norvegicus	195-198
6178473-0	1982	Myelin-associated glycoprotein localized immunocytochemically in periaxonal regions of oligodendroglia during hexachlorophene intoxication.	Hexachlorophene	110-125	myelin associated glycoprotein	Homo sapiens	0-30
642931-0	1978	Cytochrome P-450-mediated covalent binding of hexachlorophene to rat tissue proteins.	Hexachlorophene	46-61	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-17
807304-5	1975	Three factors have contributed to the subsequent resolution of the Z-fraction and partial characterization of that protein within the fraction with ligand-binding properties (Z-protein): (1) the use of hexachlorophene as ligand; (2) the inclusion of glycerol, 20%, during isolation to prevent aggregation and loss of binding-activity; and (3) the development of a charcoal binding assay.	Hexachlorophene	202-217	fatty acid binding protein 1	Rattus norvegicus	175-184
807304-11	1975	With use of the charcoal method, apparent dissociation constants for the interaction between Z-protein and hexachlorophene, bilirubin and L-thyroxine, were found to be 20, 50, and 350 muM, respectively.	Hexachlorophene	107-122	fatty acid binding protein 1	Rattus norvegicus	93-102
4739317-0	1973	The hex on, hex on hexachlorophene.	Hexachlorophene	19-34	hematopoietically expressed homeobox	Homo sapiens	4-7
4739317-0	1973	The hex on, hex on hexachlorophene.	Hexachlorophene	19-34	hematopoietically expressed homeobox	Homo sapiens	12-15
14774587-2	1950	Hexachlorophene (G-11).	Hexachlorophene	0-15	serine/threonine kinase 19	Homo sapiens	17-21
13259244-0	1955	Studies on the disinfectant properties of G-11 (hexachlorophene).	Hexachlorophene	48-63	serine/threonine kinase 19	Homo sapiens	42-46
14829711-0	1951	pH isoderm with hexachlorophene (G-11).	Hexachlorophene	16-31	serine/threonine kinase 19	Homo sapiens	33-37
14375383-0	1955	Hexachlorophene (G-11) in the treatment of eczematous dermatoses.	Hexachlorophene	0-15	serine/threonine kinase 19	Homo sapiens	17-21
15430159-0	1950	Clinical and laboratory evaluation of G-11 (hexachlorophene) as a preoperative skin bacteriostatic agent.	Hexachlorophene	44-59	serine/threonine kinase 19	Homo sapiens	38-42
31447458-5	2019	Our data reveal that expression intensity of CNPase may be dependent on the degree of HCP- and CPZ-induced damage of the myelin sheath.	Hexachlorophene	86-89	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	45-51
16561576-0	1948	Studies on the Retention of Hexachlorophene (G-11) in Human Skin.	Hexachlorophene	28-43	serine/threonine kinase 19	Homo sapiens	45-49
15393530-0	1949	pHisoderm with hexachlorophene (G-11) its integrity as a surgical scrub.	Hexachlorophene	15-30	serine/threonine kinase 19	Homo sapiens	32-36
20256802-0	1947	2,2"-Dihydroxy-3,5,6-3",5"6" hexachlorodiphenyl-methane (G-11) as an antiseptic for use in surgical scrubbing.	Hexachlorophene	0-55	serine/threonine kinase 19	Homo sapiens	57-61
30525075-1	2018	Introduction: We previously reported that transplantation of hepatic cell sheets from human bone marrow-derived mesenchymal stem cells (BM-MSCs) with hexachlorophene, a Wnt/beta-catenin signaling inhibitor, ameliorated acute liver injury.	Hexachlorophene	150-165	catenin beta 1	Homo sapiens	173-185
31129054-0	2019	A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78.	Hexachlorophene	50-65	heat shock protein family A (Hsp70) member 4	Homo sapiens	101-106
31129054-0	2019	A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78.	Hexachlorophene	50-65	heat shock protein family A (Hsp70) member 5	Homo sapiens	117-122
31129054-3	2019	This assay was used in a pilot screen to discover the anti-infective agent, hexachlorophene, as an inhibitor of GRP78.	Hexachlorophene	76-91	heat shock protein family A (Hsp70) member 5	Homo sapiens	112-117
31129054-4	2019	Through biochemical characterization we show that hexachlorophene is a competitive inhibitor of the GRP78-peptide interaction.	Hexachlorophene	50-65	heat shock protein family A (Hsp70) member 5	Homo sapiens	100-105
30525075-4	2018	The therapeutic potential of IC-2-induced hepatic cell sheets was assessed by transplantation of IC-2- and hexachlorophene-treated hepatic cell sheets using a mouse model of acute liver injury.	Hexachlorophene	107-122	dynein cytoplasmic 1 intermediate chain 2	Homo sapiens	29-33
27521834-5	2016	Four compounds, hexachlorophene, tannic acid, aurintricarboxylic acid and benserazide showed concentration-dependent CBS inhibitory actions without scavenging H2S released from GYY4137, identifying them as direct CBS inhibitors.	Hexachlorophene	16-31	cystathionine beta-synthase	Homo sapiens	117-120
27521834-6	2016	Hexachlorophene (IC50: ~60muM), tannic acid (IC50: ~40muM) and benserazide (IC50: ~30muM) were less potent CBS inhibitors than the two reference compounds AOAA (IC50: ~3muM) and NSC67078 (IC50: ~1muM), while aurintricarboxylic acid (IC50: ~3muM) was equipotent with AOAA.	Hexachlorophene	0-15	cystathionine beta-synthase	Homo sapiens	107-110
27521834-5	2016	Four compounds, hexachlorophene, tannic acid, aurintricarboxylic acid and benserazide showed concentration-dependent CBS inhibitory actions without scavenging H2S released from GYY4137, identifying them as direct CBS inhibitors.	Hexachlorophene	16-31	cystathionine beta-synthase	Homo sapiens	213-216
19531491-7	2009	Hexachlorophene forms a ring around the internal cavity in GDH through aromatic stacking interactions between the drug and GDH as well as between the drug molecules themselves.	Hexachlorophene	0-15	glutamate dehydrogenase 1	Homo sapiens	59-62
25987361-0	2015	An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug.	Hexachlorophene	59-74	TAR DNA binding protein	Homo sapiens	93-98
25987361-3	2015	We tested 281 compounds and identified a novel compound hexachlorophene (referred to as B10) that showed potent reduction in TDP43 levels.	Hexachlorophene	56-71	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	88-91
25987361-3	2015	We tested 281 compounds and identified a novel compound hexachlorophene (referred to as B10) that showed potent reduction in TDP43 levels.	Hexachlorophene	56-71	TAR DNA binding protein	Homo sapiens	125-130
25173807-5	2015	Mitoxantrone, bithionol and hexachlorophene were found to be the strongest inhibitors of fibril growth and protected primary cortical neuronal cultures against Abeta-induced toxicity.	Hexachlorophene	28-43	histocompatibility 2, class II antigen A, beta 1	Mus musculus	160-165
22313968-10	2012	These findings suggest that CNPase expression was induced in the course of restoration following HCP-induced insults to oligodendroglia and the myelin sheath, and in the course of demyelination by CPZ-induced damage to oligodendroglia.	Hexachlorophene	97-100	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	28-34
22342964-9	2012	In accordance with this, the known bovine GDH inhibitors hexachlorophene, GW5074, and bithionol were more effective on PfGDH2 than on PfGDH1.	Hexachlorophene	57-72	glucose dehydrogenase	Bos taurus	42-45
23251633-0	2012	Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants.	Hexachlorophene	0-15	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	28-33
23251633-0	2012	Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants.	Hexachlorophene	0-15	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	34-39
23251633-4	2012	In this study we report that hexachlorophene (HCP), the active component of the topical anti-infective prescription drug pHisoHex, is a KCNQ1/KCNE1 activator.	Hexachlorophene	29-44	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	136-141
23251633-4	2012	In this study we report that hexachlorophene (HCP), the active component of the topical anti-infective prescription drug pHisoHex, is a KCNQ1/KCNE1 activator.	Hexachlorophene	29-44	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	142-147
23251633-4	2012	In this study we report that hexachlorophene (HCP), the active component of the topical anti-infective prescription drug pHisoHex, is a KCNQ1/KCNE1 activator.	Hexachlorophene	46-49	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	136-141
23251633-4	2012	In this study we report that hexachlorophene (HCP), the active component of the topical anti-infective prescription drug pHisoHex, is a KCNQ1/KCNE1 activator.	Hexachlorophene	46-49	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	142-147
23251633-5	2012	HCP potently increases the current amplitude of KCNQ1/KCNE1 expressed by stabilizing the channel in an open state with an EC(50) of 4.61 +- 1.29 muM.	Hexachlorophene	0-3	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	48-53
23251633-5	2012	HCP potently increases the current amplitude of KCNQ1/KCNE1 expressed by stabilizing the channel in an open state with an EC(50) of 4.61 +- 1.29 muM.	Hexachlorophene	0-3	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	54-59
23251633-8	2012	Our results indicate HCP is a novel KCNQ1/KCNE1 activator and may be a useful tool compound for the development of LQTs therapeutics.	Hexachlorophene	21-24	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	36-41
23251633-8	2012	Our results indicate HCP is a novel KCNQ1/KCNE1 activator and may be a useful tool compound for the development of LQTs therapeutics.	Hexachlorophene	21-24	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	42-47
21196815-7	2011	Treatment with hexachlorophene (an inhibitor of beta-catenin) reduces the proliferation of pancreatic cells despite the presence of PAUF.	Hexachlorophene	15-30	catenin beta 1	Homo sapiens	48-60
21196815-7	2011	Treatment with hexachlorophene (an inhibitor of beta-catenin) reduces the proliferation of pancreatic cells despite the presence of PAUF.	Hexachlorophene	15-30	zymogen granule protein 16B	Homo sapiens	132-136
26553591-4	2015	Consequently, hexachlorophene suppressed TCF reporter activity in time- and concentration-dependent manner.	Hexachlorophene	14-29	hepatocyte nuclear factor 4 alpha	Homo sapiens	41-44
23769903-5	2013	RESULTS: We identified chlorophyllide, merbromine, hexachlorophene, and ethacrynic acid as the most effective GST P1-1 inhibitors with IC50 values in the low micromolar range.	Hexachlorophene	51-66	glutathione S-transferase pi 1	Homo sapiens	110-118
19531491-7	2009	Hexachlorophene forms a ring around the internal cavity in GDH through aromatic stacking interactions between the drug and GDH as well as between the drug molecules themselves.	Hexachlorophene	0-15	glutamate dehydrogenase 1	Homo sapiens	123-126
20692883-7	1994	CNPase, GalC and MBP levels were similar in control and low-dose (0.24 mum HCP) cultures with a general increase in MBP and CNPase over time.	Hexachlorophene	75-78	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	124-130
19091460-0	2009	Hexachlorophene suppresses beta-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells.	Hexachlorophene	0-15	catenin beta 1	Homo sapiens	27-39
19091460-0	2009	Hexachlorophene suppresses beta-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells.	Hexachlorophene	0-15	siah E3 ubiquitin protein ligase 1	Homo sapiens	71-77
19091460-3	2009	Conversely, results from cell-based small molecule screening studies have shown that the antibiotic hexachlorophene can down-regulate beta-catenin in colon cancer cells.	Hexachlorophene	100-115	catenin beta 1	Homo sapiens	134-146
19091460-4	2009	Here we report that hexachlorophene also counteracts the elevated beta-catenin levels in EBV-infected B lymphomas.	Hexachlorophene	20-35	catenin beta 1	Homo sapiens	66-78
19091460-6	2009	Our results suggest that Siah-1 is targeted by both LMP-1 and hexachlorophene with opposite effects.	Hexachlorophene	62-77	siah E3 ubiquitin protein ligase 1	Homo sapiens	25-31
19091460-7	2009	The hexachlorophene modulation of Siah-1 and beta-catenin is independent of p53 and results in reduced expression of cyclin-D1 and c-Myc (target genes of beta-catenin), leading to the growth arrest of B lymphoma cells.	Hexachlorophene	4-19	siah E3 ubiquitin protein ligase 1	Homo sapiens	34-40
19091460-7	2009	The hexachlorophene modulation of Siah-1 and beta-catenin is independent of p53 and results in reduced expression of cyclin-D1 and c-Myc (target genes of beta-catenin), leading to the growth arrest of B lymphoma cells.	Hexachlorophene	4-19	catenin beta 1	Homo sapiens	45-57
19091460-7	2009	The hexachlorophene modulation of Siah-1 and beta-catenin is independent of p53 and results in reduced expression of cyclin-D1 and c-Myc (target genes of beta-catenin), leading to the growth arrest of B lymphoma cells.	Hexachlorophene	4-19	tumor protein p53	Homo sapiens	76-79
19091460-7	2009	The hexachlorophene modulation of Siah-1 and beta-catenin is independent of p53 and results in reduced expression of cyclin-D1 and c-Myc (target genes of beta-catenin), leading to the growth arrest of B lymphoma cells.	Hexachlorophene	4-19	cyclin D1	Homo sapiens	117-126
19091460-7	2009	The hexachlorophene modulation of Siah-1 and beta-catenin is independent of p53 and results in reduced expression of cyclin-D1 and c-Myc (target genes of beta-catenin), leading to the growth arrest of B lymphoma cells.	Hexachlorophene	4-19	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	131-136
19091460-7	2009	The hexachlorophene modulation of Siah-1 and beta-catenin is independent of p53 and results in reduced expression of cyclin-D1 and c-Myc (target genes of beta-catenin), leading to the growth arrest of B lymphoma cells.	Hexachlorophene	4-19	catenin beta 1	Homo sapiens	154-166
19091460-8	2009	From these results we propose that hexachlorophene may provide a novel therapeutic strategy for EBV-infected B lymphoma cells by reducing beta-catenin levels via the restoration of Siah-1.	Hexachlorophene	35-50	catenin beta 1	Homo sapiens	138-150
19091460-8	2009	From these results we propose that hexachlorophene may provide a novel therapeutic strategy for EBV-infected B lymphoma cells by reducing beta-catenin levels via the restoration of Siah-1.	Hexachlorophene	35-50	siah E3 ubiquitin protein ligase 1	Homo sapiens	181-187
9049051-0	1997	Cooperative inhibition of acetylcholinesterase activities by hexachlorophene in human erythrocytes.	Hexachlorophene	61-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	26-46
9049051-3	1997	The inhibition of AchE activities by HCP was reversed on adding albumin.	Hexachlorophene	37-40	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-22
9049051-8	1997	On a Scatchard plot analysis, erythrocyte membranes appeared to have multiple binding sites of different affinities for HCP; binding of HCP to the low affinity site [dissociation constant (Kd) 4.7 x 10(-5) M] seemed to be responsible for the observed cooperative inhibition of AchE activities.	Hexachlorophene	136-139	acetylcholinesterase (Cartwright blood group)	Homo sapiens	277-281
9049051-10	1997	HCP seems to be the most potent cooperative inhibitor of AchE in human erythrocyte membranes known to date.	Hexachlorophene	0-3	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-61
9049051-11	1997	HCP may be useful to examine AchE and milieu in human erythrocyte membranes.	Hexachlorophene	0-3	acetylcholinesterase (Cartwright blood group)	Homo sapiens	29-33
16735606-0	2006	Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation.	Hexachlorophene	0-15	catenin beta 1	Homo sapiens	29-41
16735606-0	2006	Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation.	Hexachlorophene	0-15	catenin beta 1	Homo sapiens	77-89
16735606-3	2006	In this study, we identified hexachlorophene as an inhibitor of Wnt/beta-catenin signaling from cell-based small-molecule screening.	Hexachlorophene	29-44	catenin beta 1	Homo sapiens	68-80
16735606-4	2006	Hexachlorophene antagonized CRT that was stimulated by Wnt3a-conditioned medium by promoting the degradation of beta-catenin.	Hexachlorophene	0-15	Wnt family member 3A	Homo sapiens	55-60
16735606-4	2006	Hexachlorophene antagonized CRT that was stimulated by Wnt3a-conditioned medium by promoting the degradation of beta-catenin.	Hexachlorophene	0-15	catenin beta 1	Homo sapiens	112-124
16735606-6	2006	In addition, hexachlorophene represses the expression of cyclin D1, which is a known beta-catenin target gene, and inhibits the growth of colon cancer cells.	Hexachlorophene	13-28	cyclin D1	Homo sapiens	57-66
16735606-6	2006	In addition, hexachlorophene represses the expression of cyclin D1, which is a known beta-catenin target gene, and inhibits the growth of colon cancer cells.	Hexachlorophene	13-28	catenin beta 1	Homo sapiens	85-97
16735606-7	2006	Our findings suggest that hexachlorophene attenuates Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.	Hexachlorophene	26-41	catenin beta 1	Homo sapiens	57-69
16735606-7	2006	Our findings suggest that hexachlorophene attenuates Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.	Hexachlorophene	26-41	siah E3 ubiquitin protein ligase 1	Homo sapiens	92-98
16735606-7	2006	Our findings suggest that hexachlorophene attenuates Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.	Hexachlorophene	26-41	catenin beta 1	Homo sapiens	108-120
20692883-8	1994	Cultures exposed to 0.74 mum HCP showed a decline in GalC proportional to decreased DNA content with time, but levels of MBP and CNPase increased after dosing and were always greater than the corresponding levels in control or low-dose cultures.	Hexachlorophene	29-32	galactosylceramidase	Rattus norvegicus	53-57
20692883-9	1994	These studies suggest a direct, dose-related toxic effect of HCP accompanied by a stimulation of MBP and CNPase but not of GalC production in the membranes of the recovering OLG following removal of HCP.	Hexachlorophene	61-64	myelin basic protein	Rattus norvegicus	97-100
20692883-9	1994	These studies suggest a direct, dose-related toxic effect of HCP accompanied by a stimulation of MBP and CNPase but not of GalC production in the membranes of the recovering OLG following removal of HCP.	Hexachlorophene	61-64	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	105-111
33233525-4	2020	Inhibition of N-acylphosphatidylethanolamine-phospholipase D (NAPE-PLD) by hexachlorophene or bithionol significantly decreased the synaptamide production, indicating that synaptamide synthesis is mediated at least in part via NDoPE hydrolysis.	Hexachlorophene	75-90	N-acyl phosphatidylethanolamine phospholipase D	Mus musculus	14-60
33233525-4	2020	Inhibition of N-acylphosphatidylethanolamine-phospholipase D (NAPE-PLD) by hexachlorophene or bithionol significantly decreased the synaptamide production, indicating that synaptamide synthesis is mediated at least in part via NDoPE hydrolysis.	Hexachlorophene	75-90	N-acyl phosphatidylethanolamine phospholipase D	Mus musculus	62-70