PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30554776-9	2019	Finally, changes in plasma amino-acid levels in rats, following administration of S-methyl-l-cysteine, an alanine-serine-cysteine transporter-1 (Asc-1) inhibitor, were successfully detected by LC-MS/MS using (S)-COXA-OSu.	osu	217-220	solute carrier family 7 member 10	Rattus norvegicus	106-143
30554776-9	2019	Finally, changes in plasma amino-acid levels in rats, following administration of S-methyl-l-cysteine, an alanine-serine-cysteine transporter-1 (Asc-1) inhibitor, were successfully detected by LC-MS/MS using (S)-COXA-OSu.	osu	217-220	solute carrier family 7 member 10	Rattus norvegicus	145-150
31215362-6	2019	RhoB-OSu was further coupled to sarcosine to obtain rhodamine Bsarcosine dye (ROSA) in good yield.	osu	5-8	ras homolog family member B	Homo sapiens	0-4
30276218-4	2018	On human and murine primary B cells, OSU-T315 potently suppressed the proliferation and the production of antibodies and cytokines upon stimulation, suggesting that ILK could be a promising target in the modulation of B cell activity.	osu	37-40	integrin linked kinase	Mus musculus	165-168
30475602-3	2018	In this study, small peptide TMTP1 was designed to conjugate to a near-infrared fluorescent agent ICG derivative ICG-OSu through PEG4, forming the novel probe TMTP1-PEG4-ICG.	osu	117-120	small nuclear ribonucleoprotein N	Mus musculus	129-133
30475602-3	2018	In this study, small peptide TMTP1 was designed to conjugate to a near-infrared fluorescent agent ICG derivative ICG-OSu through PEG4, forming the novel probe TMTP1-PEG4-ICG.	osu	117-120	small nuclear ribonucleoprotein N	Mus musculus	165-169
27217374-0	2017	Disrupting Y-Box-Binding Protein 1 Function Using OSU-03012 Prevents Endometriosis Progression in In Vitro and In Vivo Models.	osu	50-53	Y-box binding protein 1	Homo sapiens	11-34
28436990-3	2017	In this study, we showed that TCRP1 overexpression promotes cell transformation and tumorigenesis through hyperphosphorylation of the oncogenic kinase 3-phosphoinositide-dependent protein kinase-1 (PDK1) and AKT1, whereas inhibition of PDK1 by OSU-03012 or PDK1 small interfering RNA reversed TCRP1-mediated cell transformation.	osu	244-247	family with sequence similarity 168 member A	Homo sapiens	30-35
27217374-6	2017	OSU-03012 treatment resulted in decreased YB-1 and its phosphorylated form in both in vitro and in vivo models.	osu	0-3	Y-box binding protein 1	Homo sapiens	42-46
27217374-9	2017	In conclusion, targeting YB-1 via OSU-03012 showed a potent antiproliferative effect on endometriotic epithelial cells in vitro and in a mouse model of disease.	osu	34-37	Y box protein 1	Mus musculus	25-29
26525215-1	2016	PURPOSE: To report our experience in long-term follow-up of ocular melanoma patients treated with custom OSU-Nag eye plaques using (125)I sources.	osu	105-108	NBAS subunit of NRZ tethering complex	Homo sapiens	109-112
27757311-5	2016	This study was designed to investigate whether treatment of MDSC with OSU-53, a PPAR-inactive derivative that stimulates AMPK kinase, can modulate MDSC function.	osu	70-73	peroxisome proliferator activated receptor alpha	Mus musculus	80-84
27757311-6	2016	Our results demonstrate that OSU-53 treatment increases the phosphorylation of AMPK, significantly reduces nitric oxide production, inhibits MDSC migration, and reduces the levels of IL-6 in murine MDSC cell line (MSC2 cells).	osu	29-32	interleukin 6	Mus musculus	183-187
27642646-7	2016	Flow cytometry shows that OSU-T315 increased the percentage of cells arrested at G2/M for both, HEI193 (39.99%) and Ben-Men-1 (26.96%) cells, compared to controls (21.54%, 8.47%).	osu	26-29	menin 1	Homo sapiens	120-125
27187154-1	2016	We have recently demonstrated that AR-12 (OSU-03012) reduces the function and ATPase activities of multiple HSP90 and HSP70 family chaperones.	osu	42-45	dynein axonemal heavy chain 8	Homo sapiens	78-84
27187154-1	2016	We have recently demonstrated that AR-12 (OSU-03012) reduces the function and ATPase activities of multiple HSP90 and HSP70 family chaperones.	osu	42-45	heat shock protein 90 alpha family class A member 1	Homo sapiens	108-113
27187154-1	2016	We have recently demonstrated that AR-12 (OSU-03012) reduces the function and ATPase activities of multiple HSP90 and HSP70 family chaperones.	osu	42-45	heat shock protein family A (Hsp70) member 4	Homo sapiens	118-123
26525215-2	2016	METHODS: A retrospective chart review was conducted for 113 consecutive ocular melanoma patients with follow-up visual acuity data who were treated with OSU-Nag plaque episcleral brachytherapy at The Ohio State University Medical Center from 1994 to 2009.	osu	153-156	NBAS subunit of NRZ tethering complex	Homo sapiens	157-160
26419972-15	2015	OSU-03012 was predicted to bind to GRP78.	osu	0-3	heat shock protein family A (Hsp70) member 5	Homo sapiens	35-40
26419972-18	2015	These studies are, to the best of our knowledge, the first studies characterizing EGCG and OSU-03012 interactions with GRP78 on a structural basis and provide a significant insight into their binding modes, selectivity, and structural stability.	osu	91-94	heat shock protein family A (Hsp70) member 5	Homo sapiens	119-124
24994714-6	2014	Phenotypic changes were mediated by Foxo3a activation, insofar as silencing or overexpressing Foxo3a mimicked the effects of AMPK silencing or OSU-53 treatment on EMT, respectively.	osu	143-146	forkhead box O3	Homo sapiens	36-42
25736380-7	2015	In multiplex assays on plasma and human tumor tissue from an OSU-03012/sildenafil treated mouse, we noted a profound reduction in uPA signaling and identified FGF and JAK1/2 as response biomarkers for potentially suppressing the killing response.	osu	61-64	Janus kinase 1	Mus musculus	167-173
25573966-1	2015	In this issue of Blood, Liu et al report on OSU-T315, a new agent that specifically disrupts the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway and shows high proapoptotic activity against chronic lymphocytic leukemia (CLL) cells, which may indicate a potential therapeutic application in this disease	osu	44-47	AKT serine/threonine kinase 1	Homo sapiens	152-155
25710562-9	2015	We demonstrated an off-target effect of direct mTOR inhibition by OSU-53.	osu	66-69	mechanistic target of rapamycin kinase	Homo sapiens	47-51
25293770-8	2015	In vivo, OSU-T315 attains pharmacologically active drug levels and significantly prolongs survival in the TCL1 mouse model.	osu	9-12	T cell lymphoma breakpoint 1	Mus musculus	106-110
25103559-3	2014	Knockdown of the endoplasmic reticulum stress response proteins IRE1 or XBP1 enhanced the lethality of OSU-03012, and of [OSU-03012 + PDE5 inhibitor] treatment.	osu	103-106	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	64-68
25103559-3	2014	Knockdown of the endoplasmic reticulum stress response proteins IRE1 or XBP1 enhanced the lethality of OSU-03012, and of [OSU-03012 + PDE5 inhibitor] treatment.	osu	103-106	X-box binding protein 1	Homo sapiens	72-76
25103559-7	2014	Knockdown of the autophagy regulatory proteins Beclin1 or ATG5 protected the cells from OSU-03012 and from [OSU-03012 + PDE5 inhibitor] toxicity.	osu	88-91	beclin 1	Homo sapiens	47-54
25103559-7	2014	Knockdown of the autophagy regulatory proteins Beclin1 or ATG5 protected the cells from OSU-03012 and from [OSU-03012 + PDE5 inhibitor] toxicity.	osu	88-91	autophagy related 5	Homo sapiens	58-62
25103559-7	2014	Knockdown of the autophagy regulatory proteins Beclin1 or ATG5 protected the cells from OSU-03012 and from [OSU-03012 + PDE5 inhibitor] toxicity.	osu	108-111	beclin 1	Homo sapiens	47-54
25103559-7	2014	Knockdown of the autophagy regulatory proteins Beclin1 or ATG5 protected the cells from OSU-03012 and from [OSU-03012 + PDE5 inhibitor] toxicity.	osu	108-111	autophagy related 5	Homo sapiens	58-62
24994714-6	2014	Phenotypic changes were mediated by Foxo3a activation, insofar as silencing or overexpressing Foxo3a mimicked the effects of AMPK silencing or OSU-53 treatment on EMT, respectively.	osu	143-146	forkhead box O3	Homo sapiens	94-100
24994714-8	2014	OSU-53 activated Foxo3a through two Akt-dependent pathways, one at the level of nuclear localization by blocking Akt- and IKKbeta-mediated phosphorylation, and a second at the level of protein stabilization via cytoplasmic sequestration of MDM2, an E3 ligase responsible for Foxo3a degradation.	osu	0-3	forkhead box O3	Homo sapiens	17-23
24994714-8	2014	OSU-53 activated Foxo3a through two Akt-dependent pathways, one at the level of nuclear localization by blocking Akt- and IKKbeta-mediated phosphorylation, and a second at the level of protein stabilization via cytoplasmic sequestration of MDM2, an E3 ligase responsible for Foxo3a degradation.	osu	0-3	AKT serine/threonine kinase 1	Homo sapiens	36-39
24994714-8	2014	OSU-53 activated Foxo3a through two Akt-dependent pathways, one at the level of nuclear localization by blocking Akt- and IKKbeta-mediated phosphorylation, and a second at the level of protein stabilization via cytoplasmic sequestration of MDM2, an E3 ligase responsible for Foxo3a degradation.	osu	0-3	AKT serine/threonine kinase 1	Homo sapiens	113-116
24994714-8	2014	OSU-53 activated Foxo3a through two Akt-dependent pathways, one at the level of nuclear localization by blocking Akt- and IKKbeta-mediated phosphorylation, and a second at the level of protein stabilization via cytoplasmic sequestration of MDM2, an E3 ligase responsible for Foxo3a degradation.	osu	0-3	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	122-129
24994714-8	2014	OSU-53 activated Foxo3a through two Akt-dependent pathways, one at the level of nuclear localization by blocking Akt- and IKKbeta-mediated phosphorylation, and a second at the level of protein stabilization via cytoplasmic sequestration of MDM2, an E3 ligase responsible for Foxo3a degradation.	osu	0-3	MDM2 proto-oncogene	Homo sapiens	240-244
24994714-8	2014	OSU-53 activated Foxo3a through two Akt-dependent pathways, one at the level of nuclear localization by blocking Akt- and IKKbeta-mediated phosphorylation, and a second at the level of protein stabilization via cytoplasmic sequestration of MDM2, an E3 ligase responsible for Foxo3a degradation.	osu	0-3	forkhead box O3	Homo sapiens	275-281
25017515-5	2014	Since Aurora kinase A is reported to phosphorylate GSK3beta, leading to its inactivation, we hypothesized that one of the targets of OSU-03012 is Aurora kinase A.	osu	133-136	aurora kinase A	Homo sapiens	6-21
25017515-5	2014	Since Aurora kinase A is reported to phosphorylate GSK3beta, leading to its inactivation, we hypothesized that one of the targets of OSU-03012 is Aurora kinase A.	osu	133-136	glycogen synthase kinase 3 beta	Homo sapiens	51-59
25017515-5	2014	Since Aurora kinase A is reported to phosphorylate GSK3beta, leading to its inactivation, we hypothesized that one of the targets of OSU-03012 is Aurora kinase A.	osu	133-136	aurora kinase A	Homo sapiens	146-161
22354011-2	2012	OSU lethality was suppressed by knock down of PERK and enhanced by knock down of ATF6 and IRE1alpha.	osu	0-3	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	46-50
23652278-10	2013	Ser-15 of p53 was phosphorylated after 24 h of treatment of the cancer cells with OSU-03012.	osu	82-85	tumor protein p53	Homo sapiens	10-13
22584165-1	2012	OSU-NAG eye plaques use fewer sources than COMS-plaques of comparable size, and do not employ a Silastic seed carrier insert.	osu	0-3	NBAS subunit of NRZ tethering complex	Homo sapiens	4-7
22584165-7	2012	Our results indicated that, to achieve a prescription dose of 85 Gy at 6 mm from the inner sclera edge for a six-day treatment, the OSU-NAG eye plaque will need 6.16 U/source and 6.82U/source for 125I and 131Cs, respectively.	osu	132-135	NBAS subunit of NRZ tethering complex	Homo sapiens	136-139
22584165-10	2012	The OSU-NAG plaque delivers about 10% and 12% more dose than the COMS for 125I and 131Cs sources, respectively, at the inner sclera edge, but 6% and 3% less dose at the opposite retina.	osu	4-7	NBAS subunit of NRZ tethering complex	Homo sapiens	8-11
22584165-12	2012	In conclusion, the dosimetric quality of the OSU-NAG eye plaque used in eye plaque brachytherapy is comparable to the COMS eye plaque.	osu	45-48	NBAS subunit of NRZ tethering complex	Homo sapiens	49-52
24569372-9	2014	Moreover, our study demonstrated that LDN/OSU-0212320 treatment results in activation of PKC and subsequent Y-box-binding protein 1 (YB-1) activation, which regulates activation of EAAT2 translation.	osu	42-45	Y box protein 1	Mus musculus	108-131
24569372-9	2014	Moreover, our study demonstrated that LDN/OSU-0212320 treatment results in activation of PKC and subsequent Y-box-binding protein 1 (YB-1) activation, which regulates activation of EAAT2 translation.	osu	42-45	Y box protein 1	Mus musculus	133-137
24569372-9	2014	Moreover, our study demonstrated that LDN/OSU-0212320 treatment results in activation of PKC and subsequent Y-box-binding protein 1 (YB-1) activation, which regulates activation of EAAT2 translation.	osu	42-45	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	181-186
22354011-2	2012	OSU lethality was suppressed by knock down of PERK and enhanced by knock down of ATF6 and IRE1alpha.	osu	0-3	activating transcription factor 6	Homo sapiens	81-85
22354011-2	2012	OSU lethality was suppressed by knock down of PERK and enhanced by knock down of ATF6 and IRE1alpha.	osu	0-3	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	90-99
22354011-3	2012	OSU treatment suppressed expression of the chaperone, BiP/GRP78, and did so through reduced stability of the protein.	osu	0-3	heat shock protein family A (Hsp70) member 5	Homo sapiens	54-57
22354011-3	2012	OSU treatment suppressed expression of the chaperone, BiP/GRP78, and did so through reduced stability of the protein.	osu	0-3	heat shock protein family A (Hsp70) member 5	Homo sapiens	58-63
22354011-4	2012	Knock down of BiP/GRP78 further enhanced OSU lethality.	osu	41-44	heat shock protein family A (Hsp70) member 5	Homo sapiens	14-17
22354011-4	2012	Knock down of BiP/GRP78 further enhanced OSU lethality.	osu	41-44	heat shock protein family A (Hsp70) member 5	Homo sapiens	18-23
22354011-8	2012	In contrast loss of PTEN function reduced OSU lethality, without altering AKT, p70 S6K or mTOR activity, or the drug"s ability to radiosensitize GBM cells.	osu	42-45	phosphatase and tensin homolog	Homo sapiens	20-24
22354011-11	2012	Collectively, our data show that reduced BiP/GRP78 levels play a key role in OSU-3012 toxicity in GBM cells, and that this drug has in vivo activity against an invasive primary human GBM isolate.	osu	77-80	heat shock protein family A (Hsp70) member 5	Homo sapiens	41-44
22354011-11	2012	Collectively, our data show that reduced BiP/GRP78 levels play a key role in OSU-3012 toxicity in GBM cells, and that this drug has in vivo activity against an invasive primary human GBM isolate.	osu	77-80	heat shock protein family A (Hsp70) member 5	Homo sapiens	45-50
18413793-4	2008	OSU-03012 sensitized both ER-positive MCF-7 and ER-negative MDA-MB-231 cells to the antiproliferative effects of tamoxifen in an ER-independent manner.	osu	0-3	estrogen receptor 1	Homo sapiens	26-28
21917926-2	2011	OSU-53 directly stimulated recombinant AMPK kinase activity (EC(50), 0.3 muM) and inhibited the viability and clonogenic growth of MDA-MB-231 and MDA-MB-468 cells with equal potency (IC(50), 5 and 2 muM, respectively) despite lack of LKB1 expression in MDA-MB-231 cells.	osu	0-3	serine/threonine kinase 11	Homo sapiens	234-238
20006997-0	2010	OSU-03012 sensitizes TIB-196 myeloma cells to imatinib mesylate via AMP-activated protein kinase and STAT3 pathways.	osu	0-3	signal transducer and activator of transcription 3	Homo sapiens	101-106
18216498-5	2008	It notes that in PKR-like endoplasmic reticulum kinase null cells (PERK-/-) the lethality of OSU is attenuated.	osu	93-96	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	67-71
18216498-6	2008	OSU enhances the expression of ATG5 in a PERK-dependent fashion and promotes the ATG5-dependent formation of vesicles containing LC3, followed by a subsequent cleavage of cathepsin B and a cathepsin B-dependent formation of low pH intracellular vesicles; cathepsin B is activated and released into the cytosol, and genetic suppression of cathepsin B or AIF function significantly suppresses cell killing.	osu	0-3	autophagy related 5	Homo sapiens	31-35
18216498-6	2008	OSU enhances the expression of ATG5 in a PERK-dependent fashion and promotes the ATG5-dependent formation of vesicles containing LC3, followed by a subsequent cleavage of cathepsin B and a cathepsin B-dependent formation of low pH intracellular vesicles; cathepsin B is activated and released into the cytosol, and genetic suppression of cathepsin B or AIF function significantly suppresses cell killing.	osu	0-3	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	41-45
18216498-6	2008	OSU enhances the expression of ATG5 in a PERK-dependent fashion and promotes the ATG5-dependent formation of vesicles containing LC3, followed by a subsequent cleavage of cathepsin B and a cathepsin B-dependent formation of low pH intracellular vesicles; cathepsin B is activated and released into the cytosol, and genetic suppression of cathepsin B or AIF function significantly suppresses cell killing.	osu	0-3	autophagy related 5	Homo sapiens	81-85
18216498-6	2008	OSU enhances the expression of ATG5 in a PERK-dependent fashion and promotes the ATG5-dependent formation of vesicles containing LC3, followed by a subsequent cleavage of cathepsin B and a cathepsin B-dependent formation of low pH intracellular vesicles; cathepsin B is activated and released into the cytosol, and genetic suppression of cathepsin B or AIF function significantly suppresses cell killing.	osu	0-3	cathepsin B	Homo sapiens	171-182
18216498-6	2008	OSU enhances the expression of ATG5 in a PERK-dependent fashion and promotes the ATG5-dependent formation of vesicles containing LC3, followed by a subsequent cleavage of cathepsin B and a cathepsin B-dependent formation of low pH intracellular vesicles; cathepsin B is activated and released into the cytosol, and genetic suppression of cathepsin B or AIF function significantly suppresses cell killing.	osu	0-3	cathepsin B	Homo sapiens	189-200
18216498-6	2008	OSU enhances the expression of ATG5 in a PERK-dependent fashion and promotes the ATG5-dependent formation of vesicles containing LC3, followed by a subsequent cleavage of cathepsin B and a cathepsin B-dependent formation of low pH intracellular vesicles; cathepsin B is activated and released into the cytosol, and genetic suppression of cathepsin B or AIF function significantly suppresses cell killing.	osu	0-3	cathepsin B	Homo sapiens	189-200
18216498-6	2008	OSU enhances the expression of ATG5 in a PERK-dependent fashion and promotes the ATG5-dependent formation of vesicles containing LC3, followed by a subsequent cleavage of cathepsin B and a cathepsin B-dependent formation of low pH intracellular vesicles; cathepsin B is activated and released into the cytosol, and genetic suppression of cathepsin B or AIF function significantly suppresses cell killing.	osu	0-3	cathepsin B	Homo sapiens	189-200
18216498-6	2008	OSU enhances the expression of ATG5 in a PERK-dependent fashion and promotes the ATG5-dependent formation of vesicles containing LC3, followed by a subsequent cleavage of cathepsin B and a cathepsin B-dependent formation of low pH intracellular vesicles; cathepsin B is activated and released into the cytosol, and genetic suppression of cathepsin B or AIF function significantly suppresses cell killing.	osu	0-3	apoptosis inducing factor mitochondria associated 1	Homo sapiens	353-356
18216498-7	2008	In parallel, OSU causes PERK-dependent increases in HSP70 expression and decreases in HSP90 and Grp78/BiP expression.	osu	13-16	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	24-28
18216498-7	2008	In parallel, OSU causes PERK-dependent increases in HSP70 expression and decreases in HSP90 and Grp78/BiP expression.	osu	13-16	heat shock protein family A (Hsp70) member 4	Homo sapiens	52-57
18216498-7	2008	In parallel, OSU causes PERK-dependent increases in HSP70 expression and decreases in HSP90 and Grp78/BiP expression.	osu	13-16	heat shock protein 90 alpha family class A member 1	Homo sapiens	86-91
18216498-7	2008	In parallel, OSU causes PERK-dependent increases in HSP70 expression and decreases in HSP90 and Grp78/BiP expression.	osu	13-16	heat shock protein family A (Hsp70) member 5	Homo sapiens	96-101
18216498-7	2008	In parallel, OSU causes PERK-dependent increases in HSP70 expression and decreases in HSP90 and Grp78/BiP expression.	osu	13-16	heat shock protein family A (Hsp70) member 5	Homo sapiens	102-105
18216498-8	2008	Inhibition of HSP70 expression enhances OSU toxicity and over-expression of HSP70 suppresses OSU-induced low pH vesicle formation and lethality.	osu	40-43	heat shock protein family A (Hsp70) member 4	Homo sapiens	14-19
18216498-8	2008	Inhibition of HSP70 expression enhances OSU toxicity and over-expression of HSP70 suppresses OSU-induced low pH vesicle formation and lethality.	osu	93-96	heat shock protein family A (Hsp70) member 4	Homo sapiens	76-81
18182481-1	2008	We have further defined mechanism(s) by which 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl}acetamide [OSU-03012 (OSU)], a derivative of the cyclooxygenase-2 (COX2) inhibitor celecoxib but lacking COX2 inhibitory activity, kills transformed cells.	osu	135-138	prostaglandin-endoperoxide synthase 2	Homo sapiens	173-189
18182481-1	2008	We have further defined mechanism(s) by which 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl}acetamide [OSU-03012 (OSU)], a derivative of the cyclooxygenase-2 (COX2) inhibitor celecoxib but lacking COX2 inhibitory activity, kills transformed cells.	osu	135-138	prostaglandin-endoperoxide synthase 2	Homo sapiens	191-195
18182481-1	2008	We have further defined mechanism(s) by which 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl}acetamide [OSU-03012 (OSU)], a derivative of the cyclooxygenase-2 (COX2) inhibitor celecoxib but lacking COX2 inhibitory activity, kills transformed cells.	osu	135-138	prostaglandin-endoperoxide synthase 2	Homo sapiens	229-233
18182481-2	2008	In cells lacking expression of protein kinase R-like endoplasmic reticulum kinase (PERK(-/-)), the lethality of OSU was attenuated.	osu	112-115	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	83-87
20107314-1	2010	The present studies focused on determining whether the autophagy-inducing drug OSU-03012 (AR-12) could enhance the toxicity of recombinant adenoviral delivery of melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) in glioblastoma multiforme (GBM) cells.	osu	79-82	interleukin 24	Homo sapiens	221-226
20107314-1	2010	The present studies focused on determining whether the autophagy-inducing drug OSU-03012 (AR-12) could enhance the toxicity of recombinant adenoviral delivery of melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) in glioblastoma multiforme (GBM) cells.	osu	79-82	interleukin 24	Homo sapiens	227-232
20107314-2	2010	The toxicity of a recombinant adenovirus to express MDA-7/IL-24 (Ad.mda-7) was enhanced by OSU-03012 in a diverse panel of primary human GBM cells.	osu	91-94	interleukin 24	Homo sapiens	52-57
20107314-2	2010	The toxicity of a recombinant adenovirus to express MDA-7/IL-24 (Ad.mda-7) was enhanced by OSU-03012 in a diverse panel of primary human GBM cells.	osu	91-94	interleukin 24	Homo sapiens	58-63
20107314-2	2010	The toxicity of a recombinant adenovirus to express MDA-7/IL-24 (Ad.mda-7) was enhanced by OSU-03012 in a diverse panel of primary human GBM cells.	osu	91-94	interleukin 24	Homo sapiens	68-73
20107314-5	2010	Knockdown of ATG5 or Beclin1 suppressed OSU-03012 enhanced MDA-7/IL-24-induced autophagy and blocked the lethal interaction between the two agents.	osu	40-43	autophagy related 5	Homo sapiens	13-17
20107314-5	2010	Knockdown of ATG5 or Beclin1 suppressed OSU-03012 enhanced MDA-7/IL-24-induced autophagy and blocked the lethal interaction between the two agents.	osu	40-43	beclin 1	Homo sapiens	21-28
20107314-5	2010	Knockdown of ATG5 or Beclin1 suppressed OSU-03012 enhanced MDA-7/IL-24-induced autophagy and blocked the lethal interaction between the two agents.	osu	40-43	interleukin 24	Homo sapiens	59-64
20107314-5	2010	Knockdown of ATG5 or Beclin1 suppressed OSU-03012 enhanced MDA-7/IL-24-induced autophagy and blocked the lethal interaction between the two agents.	osu	40-43	interleukin 24	Homo sapiens	65-70
18182481-4	2008	In parallel, OSU caused PERK-dependent increases in 70-kDa heat shock protein (HSP70) expression and decreases in 90-kDa heat shock protein (HSP90) and Grp78/BiP expression.	osu	13-16	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	24-28
18182481-4	2008	In parallel, OSU caused PERK-dependent increases in 70-kDa heat shock protein (HSP70) expression and decreases in 90-kDa heat shock protein (HSP90) and Grp78/BiP expression.	osu	13-16	heat shock protein family A (Hsp70) member 4	Homo sapiens	79-84
18182481-4	2008	In parallel, OSU caused PERK-dependent increases in 70-kDa heat shock protein (HSP70) expression and decreases in 90-kDa heat shock protein (HSP90) and Grp78/BiP expression.	osu	13-16	heat shock protein 90 alpha family class A member 1	Homo sapiens	141-146
18182481-4	2008	In parallel, OSU caused PERK-dependent increases in 70-kDa heat shock protein (HSP70) expression and decreases in 90-kDa heat shock protein (HSP90) and Grp78/BiP expression.	osu	13-16	heat shock protein family A (Hsp70) member 5	Homo sapiens	152-157
18182481-4	2008	In parallel, OSU caused PERK-dependent increases in 70-kDa heat shock protein (HSP70) expression and decreases in 90-kDa heat shock protein (HSP90) and Grp78/BiP expression.	osu	13-16	heat shock protein family A (Hsp70) member 5	Homo sapiens	158-161
18182481-6	2008	Knock-down or small-molecule inhibition of HSP70 expression enhanced OSU toxicity, and overexpression of HSP70 suppressed OSU-induced low pH vesicle formation and lethality.	osu	69-72	heat shock protein family A (Hsp70) member 4	Homo sapiens	43-48
18413793-4	2008	OSU-03012 sensitized both ER-positive MCF-7 and ER-negative MDA-MB-231 cells to the antiproliferative effects of tamoxifen in an ER-independent manner.	osu	0-3	estrogen receptor 1	Homo sapiens	48-50
18413793-4	2008	OSU-03012 sensitized both ER-positive MCF-7 and ER-negative MDA-MB-231 cells to the antiproliferative effects of tamoxifen in an ER-independent manner.	osu	0-3	estrogen receptor 1	Homo sapiens	48-50
17848913-0	2007	PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound.	osu	80-83	pyruvate dehydrogenase kinase 1	Homo sapiens	0-5
19126960-6	2008	The immunofluorescence studies suggested that the intensity of the infrared fluorescence of the ICG-ATT-labeled MUC1 antibody is stronger than the ICG-sulfo-OSu-labeled MUC1 antibody.	osu	157-160	mucin 1, cell surface associated	Homo sapiens	112-116
19126960-6	2008	The immunofluorescence studies suggested that the intensity of the infrared fluorescence of the ICG-ATT-labeled MUC1 antibody is stronger than the ICG-sulfo-OSu-labeled MUC1 antibody.	osu	157-160	mucin 1, cell surface associated	Homo sapiens	169-173
17673571-7	2007	In addition, computer modeling predicted a docking site for OSU-03012 in the ATP binding motif of PAK1.	osu	60-63	p21 (RAC1) activated kinase 1	Homo sapiens	98-102
17673571-8	2007	Finally, overexpression of constitutively activated PAK1 partially rescued the ability of motile NPA thyroid cancer cells to migrate during OSU-03012 treatment, suggesting that inhibition of PAK may be involved in the cellular effects of OSU-03012 in these cells.	osu	140-143	p21 (RAC1) activated kinase 1	Homo sapiens	52-56
17673571-8	2007	Finally, overexpression of constitutively activated PAK1 partially rescued the ability of motile NPA thyroid cancer cells to migrate during OSU-03012 treatment, suggesting that inhibition of PAK may be involved in the cellular effects of OSU-03012 in these cells.	osu	238-241	p21 (RAC1) activated kinase 1	Homo sapiens	52-56
17848913-0	2007	PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound.	osu	80-83	AKT serine/threonine kinase 1	Homo sapiens	6-9
17848913-11	2007	PDK-1/AKT pathway may be an attractive therapeutic target for cancer intervention in RMS using OSU-03012.	osu	95-98	pyruvate dehydrogenase kinase 1	Homo sapiens	0-5
17848913-11	2007	PDK-1/AKT pathway may be an attractive therapeutic target for cancer intervention in RMS using OSU-03012.	osu	95-98	AKT serine/threonine kinase 1	Homo sapiens	6-9
12747626-3	2003	SUBJECTS AND METHODS: ICG-sulfo-OSu-labeled MUC1 antibody and an IR fluorescence imaging system were employed in the present study.	osu	32-35	mucin 1, cell surface associated	Homo sapiens	44-48
19754801-4	2007	We found that Akt was constitutively phosphorylated in the canine prostate cancer cell line Ace-1 and that there was a dose-dependent decrease in cell viability, and Akt and glycogen synthase kinase-3beta phosphorylation, in response to OSU-03012 treatment.	osu	237-240	glycogen synthase kinase 3 beta	Canis lupus familiaris	174-204
16168126-10	2005	RESULTS: OSU-03012 and OSU-O3013 inhibited P-Akt and its downstream signalling through 4EBP-1 and GSK at concentrations well below that of celecoxib.	osu	9-12	AKT serine/threonine kinase 1	Homo sapiens	45-48
16168126-10	2005	RESULTS: OSU-03012 and OSU-O3013 inhibited P-Akt and its downstream signalling through 4EBP-1 and GSK at concentrations well below that of celecoxib.	osu	9-12	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	87-93
16168126-10	2005	RESULTS: OSU-03012 and OSU-O3013 inhibited P-Akt and its downstream signalling through 4EBP-1 and GSK at concentrations well below that of celecoxib.	osu	23-26	AKT serine/threonine kinase 1	Homo sapiens	45-48
16168126-10	2005	RESULTS: OSU-03012 and OSU-O3013 inhibited P-Akt and its downstream signalling through 4EBP-1 and GSK at concentrations well below that of celecoxib.	osu	23-26	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	87-93
12747626-7	2003	RESULTS: The incubation of paraffin sections with ICG-sulfo-OSu-labeled MUC1 antibody resulted in positive staining of the tumor sites by an IR fluorescence imaging system, and the intensity of fluorescence was increased depending on the concentration of octylglucoside and grade of imaging processing.	osu	60-63	mucin 1, cell surface associated	Homo sapiens	72-76
11993509-7	2002	Good images of cancer cells could be obtained by infrared fluorescence observation using the ICG-sulfo-OSu-labeled anti-MUC1 antibody.	osu	103-106	mucin 1, cell surface associated	Homo sapiens	120-124
11993509-9	2002	The ICG-sulfo-OSu-labeled anti-MUC1 antibody has possible usefulness for the screening of cancer via infrared fluorescence endoscopy.	osu	14-17	mucin 1, cell surface associated	Homo sapiens	31-35
11785890-8	2001	Both in vitro and in vivo TAst-OSU challenge resulted in reduced interleukin (IL)-1 and IL-6 activity.	osu	31-34	interleukin 6	Homo sapiens	88-92
11571680-3	2001	MATERIALS AND METHODS: ICG-sulfo-OSu-labeled mouse anti-human carcinoembryonic antigen (CEA) antibody and an infrared fluorescence endoscope were used in this study.	osu	33-36	CEA cell adhesion molecule 3	Homo sapiens	62-86
11571680-3	2001	MATERIALS AND METHODS: ICG-sulfo-OSu-labeled mouse anti-human carcinoembryonic antigen (CEA) antibody and an infrared fluorescence endoscope were used in this study.	osu	33-36	CEA cell adhesion molecule 3	Homo sapiens	88-91
11571680-6	2001	RESULTS: Treatment of freshly resected stomach specimens with ICG-sulfo-OSu-labeled-anti-CEA antibody complex resulted in positive staining of the tumor sites on infrared fluorescence endoscopy, and the infrared fluorescent images correlated well with the tumor sites.	osu	72-75	CEA cell adhesion molecule 3	Homo sapiens	89-92
34788382-5	2022	Using a novel pharmacological agent OSU-2S in parallel with genetic approaches, we discovered that PP2A enforces c-Myc and p21 dependent terminal differentiation, proliferation arrest and apoptosis in AML.	osu	36-39	protein phosphatase 2 phosphatase activator	Homo sapiens	99-103