PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 25463438-7 2015 Moreover, eIF4E1b proteins are distinguishable from eIF4E1a by a set of conserved amino acid substitutions, several of which are located near to cap-binding residues. cap 145-148 eukaryotic translation initiation factor 4E family member 1B S homeolog Xenopus laevis 10-17 25524901-3 2015 We found that mouse mammary morphogenesis during pregnancy and lactation is accompanied by increased cap-binding capability of eIF4E and activation of the eIF4E-dependent translational apparatus, but only subtle oscillations in eIF4E abundance. cap 101-104 eukaryotic translation initiation factor 4E Mus musculus 127-132 25451937-3 2015 To understand its origin, we addressed internal dynamics of CAP-Gly assembled on polymeric microtubules, bound to end-binding protein EB1 and free, by magic angle spinning NMR and molecular dynamics simulations. cap 60-63 microtubule associated protein RP/EB family member 1 Homo sapiens 134-137 25443926-11 2014 Sensitivity and specificity of PCA3 for CaP were 46.3% and 78.7%, respectively. cap 40-43 prostate cancer associated 3 Homo sapiens 31-35 25404306-4 2014 Selected 5"-tiRNAs (e.g., tiRNA(Ala), tiRNA(Cys)) cooperate with the translational repressor Y-box binding protein 1 (YB-1) to displace the cap-binding complex eIF4F from capped mRNA, inhibit translation initiation, and induce the assembly of stress granules (SGs). cap 140-143 Y-box binding protein 1 Homo sapiens 93-116 25404306-4 2014 Selected 5"-tiRNAs (e.g., tiRNA(Ala), tiRNA(Cys)) cooperate with the translational repressor Y-box binding protein 1 (YB-1) to displace the cap-binding complex eIF4F from capped mRNA, inhibit translation initiation, and induce the assembly of stress granules (SGs). cap 140-143 Y-box binding protein 1 Homo sapiens 118-122 24970798-3 2014 Here, we demonstrate that activation of cap-dependent translation by silencing the translational repressor 4E-BP1 causes cancer epithelial cells to undergo epithelial-mesenchymal transition (EMT), which is associated with selective upregulation of the EMT inducer Snail followed by repression of E-cadherin expression and promotion of cell migratory and invasive capabilities as well as metastasis. cap 40-43 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 107-113 25356869-1 2014 The eukaryotic initiation factor eIF4E is essential for cap-dependent initiation of translation in eukaryotes. cap 56-59 eukaryotic translation initiation factor 4E Homo sapiens 33-38 24970798-3 2014 Here, we demonstrate that activation of cap-dependent translation by silencing the translational repressor 4E-BP1 causes cancer epithelial cells to undergo epithelial-mesenchymal transition (EMT), which is associated with selective upregulation of the EMT inducer Snail followed by repression of E-cadherin expression and promotion of cell migratory and invasive capabilities as well as metastasis. cap 40-43 snail family transcriptional repressor 1 Homo sapiens 264-269 24970798-3 2014 Here, we demonstrate that activation of cap-dependent translation by silencing the translational repressor 4E-BP1 causes cancer epithelial cells to undergo epithelial-mesenchymal transition (EMT), which is associated with selective upregulation of the EMT inducer Snail followed by repression of E-cadherin expression and promotion of cell migratory and invasive capabilities as well as metastasis. cap 40-43 cadherin 1 Homo sapiens 296-306 24970817-6 2014 Treatment with LY294002, a PI3K inhibitor, resulted in cell cycle arrest without apoptosis and a concomitant down-regulation of cap-dependent translation by the suppression of the PI3K/AKT/mTOR pathway. cap 128-131 AKT serine/threonine kinase 1 Homo sapiens 185-188 25059720-3 2014 p150(glued) contains an N-terminal microtubule-binding cytoskeleton-associated protein glycine-rich (CAP-Gly) domain that accelerates tubulin polymerization. cap 101-104 chromatin assembly factor 1 subunit A Homo sapiens 0-4 25059720-3 2014 p150(glued) contains an N-terminal microtubule-binding cytoskeleton-associated protein glycine-rich (CAP-Gly) domain that accelerates tubulin polymerization. cap 101-104 chromatin assembly factor 1 subunit A Homo sapiens 5-10 24970817-6 2014 Treatment with LY294002, a PI3K inhibitor, resulted in cell cycle arrest without apoptosis and a concomitant down-regulation of cap-dependent translation by the suppression of the PI3K/AKT/mTOR pathway. cap 128-131 mechanistic target of rapamycin kinase Homo sapiens 189-193 24970817-7 2014 However, the inhibition of cap-dependent translation by ERBB3 knockdown occurred without altering the PI3K/AKT/mTOR pathway. cap 27-30 erb-b2 receptor tyrosine kinase 3 Homo sapiens 56-61 23624914-3 2014 Our recent study showed that both ERK and AKT signaling are required to activate eukaryotic translation initiation factor 4E (eIF4E)-initiated cap-dependent translation via convergent regulation of the translational repressor 4E-binding protein 1 (4E-BP1) for maintaining CRC transformation. cap 143-146 mitogen-activated protein kinase 1 Homo sapiens 34-37 24198165-6 2014 High OT (62.5 nM) reduced translation initiation factor 4E-BP1 phosphorylation (Ser65), which is known to inhibit cap-dependent translation via its rate-limiting eukaryotic translation initiation factor 4E (eIF4E). cap 114-117 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 56-62 26779406-9 2014 Our findings suggest a physiological link between the cap-independent mechanism and the enhanced translation of hsp-3 and ced-9. cap 54-57 Heat shock 70 kDa protein C Caenorhabditis elegans 112-117 26779406-9 2014 Our findings suggest a physiological link between the cap-independent mechanism and the enhanced translation of hsp-3 and ced-9. cap 54-57 Apoptosis regulator ced-9 Caenorhabditis elegans 122-127 24486724-3 2014 Using activated mouse splenic CD4 T cells we demonstrate that ICOS assists TCR-mediated signal transduction by potentiating the PI3K-AKT-mTOR signaling cascade that leads to hyper-phosphorylation of p70S6K and 4E-BP1, events that are known to augment cap-dependent mRNA translation. cap 251-254 inducible T cell co-stimulator Mus musculus 62-66 24486724-3 2014 Using activated mouse splenic CD4 T cells we demonstrate that ICOS assists TCR-mediated signal transduction by potentiating the PI3K-AKT-mTOR signaling cascade that leads to hyper-phosphorylation of p70S6K and 4E-BP1, events that are known to augment cap-dependent mRNA translation. cap 251-254 ribosomal protein S6 kinase, polypeptide 1 Mus musculus 199-216 23624914-3 2014 Our recent study showed that both ERK and AKT signaling are required to activate eukaryotic translation initiation factor 4E (eIF4E)-initiated cap-dependent translation via convergent regulation of the translational repressor 4E-binding protein 1 (4E-BP1) for maintaining CRC transformation. cap 143-146 AKT serine/threonine kinase 1 Homo sapiens 42-45 23624914-3 2014 Our recent study showed that both ERK and AKT signaling are required to activate eukaryotic translation initiation factor 4E (eIF4E)-initiated cap-dependent translation via convergent regulation of the translational repressor 4E-binding protein 1 (4E-BP1) for maintaining CRC transformation. cap 143-146 eukaryotic translation initiation factor 4E Homo sapiens 81-124 23624914-3 2014 Our recent study showed that both ERK and AKT signaling are required to activate eukaryotic translation initiation factor 4E (eIF4E)-initiated cap-dependent translation via convergent regulation of the translational repressor 4E-binding protein 1 (4E-BP1) for maintaining CRC transformation. cap 143-146 eukaryotic translation initiation factor 4E Homo sapiens 126-131 23624914-3 2014 Our recent study showed that both ERK and AKT signaling are required to activate eukaryotic translation initiation factor 4E (eIF4E)-initiated cap-dependent translation via convergent regulation of the translational repressor 4E-binding protein 1 (4E-BP1) for maintaining CRC transformation. cap 143-146 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 226-246 23624914-3 2014 Our recent study showed that both ERK and AKT signaling are required to activate eukaryotic translation initiation factor 4E (eIF4E)-initiated cap-dependent translation via convergent regulation of the translational repressor 4E-binding protein 1 (4E-BP1) for maintaining CRC transformation. cap 143-146 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 248-254 23624914-4 2014 Here, we identified that the activation of cap-dependent translation by cooperative ERK and AKT signaling is critical for promotion of CRC motility and metastasis. cap 43-46 mitogen-activated protein kinase 1 Homo sapiens 84-87 23624914-4 2014 Here, we identified that the activation of cap-dependent translation by cooperative ERK and AKT signaling is critical for promotion of CRC motility and metastasis. cap 43-46 AKT serine/threonine kinase 1 Homo sapiens 92-95 24200467-4 2014 In mammals, cap synthesis is catalysed by the sequential action of RNGTT (RNA guanylyltransferase and 5"-phosphatase) and RNMT (RNA guanine-7 methyltransferase), enzymes recruited to RNA pol II (polymerase II) during the early stages of transcription. cap 12-15 RNA guanylyltransferase and 5'-phosphatase Homo sapiens 67-72 24501003-6 2014 Purified recombinant eIF4E1b and eIF4E1c proteins retain cap-binding ability and form functional complexes in vitro with eIF4G. cap 57-60 Eukaryotic initiation factor 4E protein Arabidopsis thaliana 21-28 24501003-6 2014 Purified recombinant eIF4E1b and eIF4E1c proteins retain cap-binding ability and form functional complexes in vitro with eIF4G. cap 57-60 translation initiation factor Arabidopsis thaliana 33-40 24200467-4 2014 In mammals, cap synthesis is catalysed by the sequential action of RNGTT (RNA guanylyltransferase and 5"-phosphatase) and RNMT (RNA guanine-7 methyltransferase), enzymes recruited to RNA pol II (polymerase II) during the early stages of transcription. cap 12-15 RNA guanylyltransferase and 5'-phosphatase Homo sapiens 74-116 24200467-4 2014 In mammals, cap synthesis is catalysed by the sequential action of RNGTT (RNA guanylyltransferase and 5"-phosphatase) and RNMT (RNA guanine-7 methyltransferase), enzymes recruited to RNA pol II (polymerase II) during the early stages of transcription. cap 12-15 RNA guanine-7 methyltransferase Homo sapiens 122-126 24200467-4 2014 In mammals, cap synthesis is catalysed by the sequential action of RNGTT (RNA guanylyltransferase and 5"-phosphatase) and RNMT (RNA guanine-7 methyltransferase), enzymes recruited to RNA pol II (polymerase II) during the early stages of transcription. cap 12-15 RNA guanine-7 methyltransferase Homo sapiens 128-159 23273915-6 2013 Furthermore, we found that S6K1 short isoforms bind and activate mTORC1, elevating 4E-BP1 phosphorylation, cap-dependent translation, and Mcl-1 protein levels. cap 107-110 ribosomal protein S6 kinase B1 Homo sapiens 27-31 24180592-5 2013 m7GTP-Sepharose-binding assay revealed that Src activity is required to form eIF4F complex which is necessary for Cap-dependent translation in alpha6beta4 expressing human cancer cells. cap 114-117 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 44-47 23523430-7 2013 We show that the Thor gene, which encodes eIF4E-binding protein (4E-BP), the evolutionarily conserved inhibitor of cap-dependent translation and potent inhibitor of cell growth, is involved in the development of this phenotype. cap 115-118 thor Drosophila melanogaster 65-70 23434932-3 2013 In both streptozotocin (STZ)-treated mice and cells in culture exposed to hyperglycemic conditions, expression of 4E-BP1 and its interaction with the mRNA cap-binding protein eIF4E were enhanced in conjunction with downregulation of cap-dependent and concomitant upregulation of cap-independent mRNA translation, as assessed by a bicistronic luciferase reporter assay. cap 155-158 eukaryotic translation initiation factor 4E binding protein 1 Mus musculus 114-120 23434932-3 2013 In both streptozotocin (STZ)-treated mice and cells in culture exposed to hyperglycemic conditions, expression of 4E-BP1 and its interaction with the mRNA cap-binding protein eIF4E were enhanced in conjunction with downregulation of cap-dependent and concomitant upregulation of cap-independent mRNA translation, as assessed by a bicistronic luciferase reporter assay. cap 155-158 eukaryotic translation initiation factor 4E Mus musculus 175-180 23231881-2 2013 mTOR belongs to the phosphoinositide 3-kinase (PI3-K)-related kinase family, and an aberrant activation of mTORC1 is a potential contributing factor in uncontrolled cell growth, proliferation, and survival of tumor cells via specific effects on cap-dependent translation initiation, as well as in a more sustained manner via advancing ribosome biogenesis. cap 245-248 mechanistic target of rapamycin kinase Homo sapiens 0-4 23231881-2 2013 mTOR belongs to the phosphoinositide 3-kinase (PI3-K)-related kinase family, and an aberrant activation of mTORC1 is a potential contributing factor in uncontrolled cell growth, proliferation, and survival of tumor cells via specific effects on cap-dependent translation initiation, as well as in a more sustained manner via advancing ribosome biogenesis. cap 245-248 CREB regulated transcription coactivator 1 Mus musculus 107-113 23402580-10 2013 RESULTS: IR induced caspase-dependent cleavage of the translational initiation factors eIF4G1, eIF3A, and eIF4B resulting in disassembly of the cap-dependent initiation complex. cap 144-147 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 87-93 23402580-10 2013 RESULTS: IR induced caspase-dependent cleavage of the translational initiation factors eIF4G1, eIF3A, and eIF4B resulting in disassembly of the cap-dependent initiation complex. cap 144-147 eukaryotic translation initiation factor 3 subunit A Homo sapiens 95-100 23402580-10 2013 RESULTS: IR induced caspase-dependent cleavage of the translational initiation factors eIF4G1, eIF3A, and eIF4B resulting in disassembly of the cap-dependent initiation complex. cap 144-147 eukaryotic translation initiation factor 4B Homo sapiens 106-111 22913624-5 2013 Animals were given a combined treatment of furosemide and a low dose of captopril (furo/cap), comprising a diuretic and an angiotensin-converting enzyme inhibitor, respectively, to elevate endogenous AngII levels in the brain. cap 72-75 angiotensinogen Rattus norvegicus 200-205 23855620-6 2013 CAP-DRPs were more frequently found in patients with HCAP (26.6%) than in patients with CAP (8.6%). cap 0-3 structural maintenance of chromosomes 3 Homo sapiens 53-57 23200668-6 2013 Inhibition of the PI3K/mTOR/4EBP1 by NVP-BEZ235 results in suppression of the cap-dependent translation initiation complex and concomitant downregulation of Mcl-1 in GCB cell lines. cap 78-81 mechanistic target of rapamycin kinase Homo sapiens 23-27 23200668-6 2013 Inhibition of the PI3K/mTOR/4EBP1 by NVP-BEZ235 results in suppression of the cap-dependent translation initiation complex and concomitant downregulation of Mcl-1 in GCB cell lines. cap 78-81 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 28-33 24019950-10 2013 Similarly, an increase in cap-dependent translation seen with overexpression of elongation factor 2 kinase did not depend on the uORF. cap 26-29 eukaryotic elongation factor 2 kinase Homo sapiens 80-106 24308236-7 2013 Furthermore, high IL-6 producer genotypes (GG or GC) were more frequent in controls than in CaP group (86.7% vs 80.8%, respectively, p = 0.147). cap 92-95 interleukin 6 Homo sapiens 18-22 23901100-8 2013 Finally, we have successfully separated the two functions of eIF4E to show that its helicase promoting activity increases the rate of translation by a mechanism that is distinct from its cap-binding function. cap 187-190 eukaryotic translation initiation factor 4E Homo sapiens 61-66 23747720-2 2013 Cancer cells treated with the plant-derived perillyl alcohol (POH) or the mechanistic target of rapamycin (mTOR) inhibitor rapamycin dephosphorylate eIF4E-binding protein (4E-BP1) and attenuate cap-dependent translation. cap 194-197 serine/threonine-protein kinase mTOR Cricetulus griseus 74-105 23747720-2 2013 Cancer cells treated with the plant-derived perillyl alcohol (POH) or the mechanistic target of rapamycin (mTOR) inhibitor rapamycin dephosphorylate eIF4E-binding protein (4E-BP1) and attenuate cap-dependent translation. cap 194-197 serine/threonine-protein kinase mTOR Cricetulus griseus 107-111 23667251-0 2013 Hypoxia-inducible factor-1alpha (HIF-1alpha) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions. cap 54-57 hypoxia inducible factor 1 subunit alpha Homo sapiens 0-31 23667251-0 2013 Hypoxia-inducible factor-1alpha (HIF-1alpha) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions. cap 54-57 hypoxia inducible factor 1 subunit alpha Homo sapiens 33-43 23667251-0 2013 Hypoxia-inducible factor-1alpha (HIF-1alpha) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions. cap 54-57 eukaryotic translation initiation factor 4E Homo sapiens 139-145 23667251-3 2013 However, whether and how HIF-1alpha affects cap-dependent translation through eIF4Es in hypoxic cancer cells has been unknown. cap 44-47 hypoxia inducible factor 1 subunit alpha Homo sapiens 25-35 23547259-5 2013 Here, we report a novel role of the mTORC1-eukaryotic translation initiation factor 4E (eIF4E) pathway, a key regulator of cap-dependent translation initiation of oncogenic factors, in SG formation. cap 123-126 CREB regulated transcription coactivator 1 Mus musculus 36-42 23547259-5 2013 Here, we report a novel role of the mTORC1-eukaryotic translation initiation factor 4E (eIF4E) pathway, a key regulator of cap-dependent translation initiation of oncogenic factors, in SG formation. cap 123-126 eukaryotic translation initiation factor 4E Homo sapiens 88-93 23704990-8 2013 Concomitant treatment with CAP and TMZ led to inhibition of cell growth and cell cycle arrest, thus CAP might be a promising candidate for combination therapy especially for patients suffering from GBMs showing an unfavorable MGMT status and TMZ resistance. cap 27-30 O-6-methylguanine-DNA methyltransferase Homo sapiens 226-230 23704990-8 2013 Concomitant treatment with CAP and TMZ led to inhibition of cell growth and cell cycle arrest, thus CAP might be a promising candidate for combination therapy especially for patients suffering from GBMs showing an unfavorable MGMT status and TMZ resistance. cap 100-103 O-6-methylguanine-DNA methyltransferase Homo sapiens 226-230 23051183-10 2013 In the receiver operating characteristic analysis, plasma HBD-2 concentration had an area under the curve of 0.77 (95% CI 0.71-0.82); the optimal cutoff point was 12.5 mg/L (sensitivity of 63%, specificity of 84%, positive predictive value of 42%, and negative predictive value of 88%), which predicted 30-day adverse outcomes in subjects with CAP. cap 344-347 defensin beta 4A Homo sapiens 58-63 23269249-3 2013 It has been hypothesized that MAPK-interacting kinase 1 and 2 (Mnk1/2) promote cap-dependent translation by phosphorylating eIF4E at serine 209 (S209). cap 79-82 mitogen-activated protein kinase 3 Mus musculus 63-69 23269249-3 2013 It has been hypothesized that MAPK-interacting kinase 1 and 2 (Mnk1/2) promote cap-dependent translation by phosphorylating eIF4E at serine 209 (S209). cap 79-82 eukaryotic translation initiation factor 4E Mus musculus 124-129 23273915-6 2013 Furthermore, we found that S6K1 short isoforms bind and activate mTORC1, elevating 4E-BP1 phosphorylation, cap-dependent translation, and Mcl-1 protein levels. cap 107-110 CREB regulated transcription coactivator 1 Mus musculus 65-71 22507384-0 2012 Cap binding-independent recruitment of eIF4E to cytoplasmic foci. cap 0-3 eukaryotic translation initiation factor 4E1 Drosophila melanogaster 39-44 23263185-5 2013 Here we show that genetically increasing the levels of eukaryotic translation initiation factor 4E (eIF4E) in mice results in exaggerated cap-dependent translation and aberrant behaviours reminiscent of autism, including repetitive and perseverative behaviours and social interaction deficits. cap 138-141 eukaryotic translation initiation factor 4E Mus musculus 55-98 23263185-5 2013 Here we show that genetically increasing the levels of eukaryotic translation initiation factor 4E (eIF4E) in mice results in exaggerated cap-dependent translation and aberrant behaviours reminiscent of autism, including repetitive and perseverative behaviours and social interaction deficits. cap 138-141 eukaryotic translation initiation factor 4E Mus musculus 100-105 23263185-7 2013 The autistic-like behaviours displayed by the eIF4E-transgenic mice are corrected by intracerebroventricular infusions of the cap-dependent translation inhibitor 4EGI-1. cap 126-129 eukaryotic translation initiation factor 4E Mus musculus 46-51 23175522-2 2013 Cap-dependent mRNA translation can be however inhibited by the eIF4E-binding protein 1 (4E-BP1). cap 0-3 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 63-86 23175522-2 2013 Cap-dependent mRNA translation can be however inhibited by the eIF4E-binding protein 1 (4E-BP1). cap 0-3 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 88-94 22767218-0 2012 Cap-dependent mRNA translation and the ubiquitin-proteasome system cooperate to promote ERBB2-dependent esophageal cancer phenotype. cap 0-3 erb-b2 receptor tyrosine kinase 2 Homo sapiens 88-93 22887640-6 2013 In osteoclasts actively resorbing bone, dynein-dynactin intimately co-localizes with the CAP-Gly domain-containing microtubule plus-end protein CLIP-170 at the resorptive front, thus orientating the ruffled border as a microtubule plus-end domain. cap 89-92 CAP-Gly domain containing linker protein 1 Homo sapiens 144-152 23409027-5 2013 Taken together, these data suggest that eIF4GI participates in the miRNA-mediated post-transcriptional gene silencing by promoting the association of Ago2 with the cap-binding complex. cap 164-167 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 40-46 23409027-5 2013 Taken together, these data suggest that eIF4GI participates in the miRNA-mediated post-transcriptional gene silencing by promoting the association of Ago2 with the cap-binding complex. cap 164-167 argonaute RISC catalytic component 2 Homo sapiens 150-154 23168703-13 2012 INTERPRETATION & CONCLUSIONS: The results of the present study demonstrate that TP53 codon 72 polymorphism plays significant role in the pathogenesis and susceptibility to CaP and BPH. cap 176-179 tumor protein p53 Homo sapiens 84-88 22700859-11 2012 Respiratory syncytial virus was significantly more common in the CAP group (CAP, 10.9%; HCAP, 2.2%; P = 0.01). cap 65-68 structural maintenance of chromosomes 3 Homo sapiens 88-92 22507384-1 2012 Eukaryotic translation initiation factor 4E (eIF4E) is required for cap-dependent initiation. cap 68-71 eukaryotic translation initiation factor 4E1 Drosophila melanogaster 0-43 22507384-1 2012 Eukaryotic translation initiation factor 4E (eIF4E) is required for cap-dependent initiation. cap 68-71 eukaryotic translation initiation factor 4E1 Drosophila melanogaster 45-50 22622238-6 2012 RESULTS: NPr-4-S-CAP suppressed growth of pigmented melanoma cells associated with an increase of intracellular ROS, activation of caspase 3 and DNA fragmentation, suggesting that NPr-4-S-CAP mediated ROS production, eliciting apoptosis of melanoma cells. cap 17-20 caspase 3 Mus musculus 131-140 22622238-9 2012 Tetramer assay demonstrated increased TYRP-2-specific CD8(+) T cells in the lymph node and spleen cells prepared from NPr-4-S-CAP-treated B16F1-bearing mice. cap 126-129 dopachrome tautomerase Mus musculus 38-44 22521877-0 2012 Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response. cap 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 16-20 22495651-0 2012 Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target. cap 0-3 eukaryotic translation initiation factor 4E Homo sapiens 44-49 22418586-10 2012 CAP exposure suppressed vascular endothelial growth factor (VEGF)-induced Akt and endothelial nitric oxide synthase (eNOS) phosphorylation in the aorta, and it prevented VEGF/AMD3100-induced mobilization of Flk-1(+)/Sca-1(+) cells into the peripheral blood. cap 0-3 vascular endothelial growth factor A Mus musculus 24-58 22418586-10 2012 CAP exposure suppressed vascular endothelial growth factor (VEGF)-induced Akt and endothelial nitric oxide synthase (eNOS) phosphorylation in the aorta, and it prevented VEGF/AMD3100-induced mobilization of Flk-1(+)/Sca-1(+) cells into the peripheral blood. cap 0-3 vascular endothelial growth factor A Mus musculus 60-64 22418586-10 2012 CAP exposure suppressed vascular endothelial growth factor (VEGF)-induced Akt and endothelial nitric oxide synthase (eNOS) phosphorylation in the aorta, and it prevented VEGF/AMD3100-induced mobilization of Flk-1(+)/Sca-1(+) cells into the peripheral blood. cap 0-3 vascular endothelial growth factor A Mus musculus 170-174 22418586-10 2012 CAP exposure suppressed vascular endothelial growth factor (VEGF)-induced Akt and endothelial nitric oxide synthase (eNOS) phosphorylation in the aorta, and it prevented VEGF/AMD3100-induced mobilization of Flk-1(+)/Sca-1(+) cells into the peripheral blood. cap 0-3 thymoma viral proto-oncogene 1 Mus musculus 74-77 22418586-10 2012 CAP exposure suppressed vascular endothelial growth factor (VEGF)-induced Akt and endothelial nitric oxide synthase (eNOS) phosphorylation in the aorta, and it prevented VEGF/AMD3100-induced mobilization of Flk-1(+)/Sca-1(+) cells into the peripheral blood. cap 0-3 kinase insert domain protein receptor Mus musculus 207-215 22418586-10 2012 CAP exposure suppressed vascular endothelial growth factor (VEGF)-induced Akt and endothelial nitric oxide synthase (eNOS) phosphorylation in the aorta, and it prevented VEGF/AMD3100-induced mobilization of Flk-1(+)/Sca-1(+) cells into the peripheral blood. cap 0-3 nitric oxide synthase 3, endothelial cell Mus musculus 82-115 22418586-10 2012 CAP exposure suppressed vascular endothelial growth factor (VEGF)-induced Akt and endothelial nitric oxide synthase (eNOS) phosphorylation in the aorta, and it prevented VEGF/AMD3100-induced mobilization of Flk-1(+)/Sca-1(+) cells into the peripheral blood. cap 0-3 ataxin 1 Mus musculus 216-221 22392810-5 2012 Targeting the cap-binding pocket of eIF4E should represent a way to inhibit all the eIF4E cellular functions. cap 14-17 eukaryotic translation initiation factor 4E Homo sapiens 36-41 22392810-5 2012 Targeting the cap-binding pocket of eIF4E should represent a way to inhibit all the eIF4E cellular functions. cap 14-17 eukaryotic translation initiation factor 4E Homo sapiens 84-89 22348735-13 2012 CONCLUSIONS: IL-6, IL-10 and LBP concentrations were increased in patients with a CRB-65 score of 3-4 and a severe course of CAP. cap 125-128 interleukin 6 Homo sapiens 13-17 22500638-6 2012 Our findings suggest that cap-dependent translation under the control of TOR plays a critical role in establishing the activity dependent homeostatic response at the NMJ. cap 26-29 Target of rapamycin Drosophila melanogaster 73-76 22348735-13 2012 CONCLUSIONS: IL-6, IL-10 and LBP concentrations were increased in patients with a CRB-65 score of 3-4 and a severe course of CAP. cap 125-128 interleukin 10 Homo sapiens 19-24 22348735-13 2012 CONCLUSIONS: IL-6, IL-10 and LBP concentrations were increased in patients with a CRB-65 score of 3-4 and a severe course of CAP. cap 125-128 lipopolysaccharide binding protein Homo sapiens 29-32 21841310-6 2011 MCV sT was found to act downstream in the mammalian target of rapamycin (mTOR) signaling pathway to preserve eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) hyperphosphorylation, resulting in dysregulated cap-dependent translation. cap 228-231 mechanistic target of rapamycin kinase Homo sapiens 73-77 22076560-4 2012 We have previously observed that inhibition of c-jun N-terminal kinase (JNK) leads to inactivation of cap-dependent translation in mesothelioma cells. cap 114-117 mitogen-activated protein kinase 8 Homo sapiens 47-70 22076560-4 2012 We have previously observed that inhibition of c-jun N-terminal kinase (JNK) leads to inactivation of cap-dependent translation in mesothelioma cells. cap 114-117 mitogen-activated protein kinase 8 Homo sapiens 72-75 22076560-5 2012 Since JNK is involved in the genesis of non-small cell lung cancer (NSCLC), we hypothesized that JNK could also be involved in activating cap-dependent translation in NSCLC cells and could represent an alternative pathway regulating translation. cap 162-165 mitogen-activated protein kinase 8 Homo sapiens 6-9 22076560-5 2012 Since JNK is involved in the genesis of non-small cell lung cancer (NSCLC), we hypothesized that JNK could also be involved in activating cap-dependent translation in NSCLC cells and could represent an alternative pathway regulating translation. cap 162-165 mitogen-activated protein kinase 8 Homo sapiens 121-124 22076560-6 2012 In a series of NSCLC cell lines, inhibition of JNK using SP600125 resulted in inhibition of 4E-BP1 phosphorylation and a decrease in formation of the cap-dependent translation complex, eIF4F. cap 174-177 mitogen-activated protein kinase 8 Homo sapiens 59-62 22076560-6 2012 In a series of NSCLC cell lines, inhibition of JNK using SP600125 resulted in inhibition of 4E-BP1 phosphorylation and a decrease in formation of the cap-dependent translation complex, eIF4F. cap 174-177 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 221-226 22182671-7 2012 Even though both types of RB cells express TRPV1 as well as TRPM8 and CB1, the capsaicin (50 muM) (CAP)-induced Ca(2+) rise caused by TRPV1 activation was prompt and transient only in etoposide-resistant RB cells (n = 8). cap 99-102 transient receptor potential cation channel subfamily V member 1 Homo sapiens 43-48 22182671-7 2012 Even though both types of RB cells express TRPV1 as well as TRPM8 and CB1, the capsaicin (50 muM) (CAP)-induced Ca(2+) rise caused by TRPV1 activation was prompt and transient only in etoposide-resistant RB cells (n = 8). cap 99-102 transient receptor potential cation channel subfamily M member 8 Homo sapiens 60-65 22182671-7 2012 Even though both types of RB cells express TRPV1 as well as TRPM8 and CB1, the capsaicin (50 muM) (CAP)-induced Ca(2+) rise caused by TRPV1 activation was prompt and transient only in etoposide-resistant RB cells (n = 8). cap 99-102 cannabinoid receptor 1 Homo sapiens 70-73 22182671-7 2012 Even though both types of RB cells express TRPV1 as well as TRPM8 and CB1, the capsaicin (50 muM) (CAP)-induced Ca(2+) rise caused by TRPV1 activation was prompt and transient only in etoposide-resistant RB cells (n = 8). cap 99-102 latexin Homo sapiens 93-96 22182671-7 2012 Even though both types of RB cells express TRPV1 as well as TRPM8 and CB1, the capsaicin (50 muM) (CAP)-induced Ca(2+) rise caused by TRPV1 activation was prompt and transient only in etoposide-resistant RB cells (n = 8). cap 99-102 transient receptor potential cation channel subfamily V member 1 Homo sapiens 134-139 21638082-6 2011 When tested for the role of PERK and GCN2 on basal translation from the HCV IRES under non-stressed condition, we found that basal translation from the HCV IRES was also favoured in the presence of PERK or GCN2 in MEFs over that of cap-dependent translation and was favoured in the presence of GCN2 but not PERK in Huh-7 cells. cap 232-235 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 198-202 21638082-6 2011 When tested for the role of PERK and GCN2 on basal translation from the HCV IRES under non-stressed condition, we found that basal translation from the HCV IRES was also favoured in the presence of PERK or GCN2 in MEFs over that of cap-dependent translation and was favoured in the presence of GCN2 but not PERK in Huh-7 cells. cap 232-235 eukaryotic translation initiation factor 2 alpha kinase 4 Homo sapiens 206-210 21638082-6 2011 When tested for the role of PERK and GCN2 on basal translation from the HCV IRES under non-stressed condition, we found that basal translation from the HCV IRES was also favoured in the presence of PERK or GCN2 in MEFs over that of cap-dependent translation and was favoured in the presence of GCN2 but not PERK in Huh-7 cells. cap 232-235 eukaryotic translation initiation factor 2 alpha kinase 4 Homo sapiens 206-210 21638082-6 2011 When tested for the role of PERK and GCN2 on basal translation from the HCV IRES under non-stressed condition, we found that basal translation from the HCV IRES was also favoured in the presence of PERK or GCN2 in MEFs over that of cap-dependent translation and was favoured in the presence of GCN2 but not PERK in Huh-7 cells. cap 232-235 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 198-202 21337679-1 2012 BACKGROUND: AZD8055 is a small molecule ATP-competitive inhibitor of the serine/threonine kinase mTOR that regulates cap-dependent translation through the mTORC1 complex and Akt activation through the mTORC2 complex. cap 117-120 mechanistic target of rapamycin kinase Homo sapiens 97-101 21337679-1 2012 BACKGROUND: AZD8055 is a small molecule ATP-competitive inhibitor of the serine/threonine kinase mTOR that regulates cap-dependent translation through the mTORC1 complex and Akt activation through the mTORC2 complex. cap 117-120 CREB regulated transcription coactivator 1 Mus musculus 155-161 22119847-10 2012 We succeeded to solve the crystal structure of a complex composed of a heterodimer of EB1 and EB3 C-termini together with the CAP-Gly domain of p150(glued). cap 126-129 microtubule associated protein RP/EB family member 1 Homo sapiens 86-89 22119847-10 2012 We succeeded to solve the crystal structure of a complex composed of a heterodimer of EB1 and EB3 C-termini together with the CAP-Gly domain of p150(glued). cap 126-129 chromatin assembly factor 1 subunit A Homo sapiens 144-148 22119847-10 2012 We succeeded to solve the crystal structure of a complex composed of a heterodimer of EB1 and EB3 C-termini together with the CAP-Gly domain of p150(glued). cap 126-129 chromatin assembly factor 1 subunit A Homo sapiens 149-154 21859846-0 2011 Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. cap 10-13 AKT serine/threonine kinase 1 Homo sapiens 74-77 21402045-6 2011 This enhanced biochemical assay is also suitable for measuring the inhibition of PDK1 by several selective compounds from the carbonyl-4-amino-pyrrolopyrimidine (CAP) series. cap 162-165 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial Cricetulus griseus 81-85 21859846-0 2011 Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. cap 10-13 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 82-85 21606676-2 2011 One important strategy for stimulating protein synthesis involves the ser/thr kinase Akt, which subsequently triggers inactivation of the cap-dependent translational repressor 4E-BP1 by an mTOR-containing protein complex (mTORC1). cap 138-141 AKT serine/threonine kinase 1 Homo sapiens 85-88 21606676-2 2011 One important strategy for stimulating protein synthesis involves the ser/thr kinase Akt, which subsequently triggers inactivation of the cap-dependent translational repressor 4E-BP1 by an mTOR-containing protein complex (mTORC1). cap 138-141 mechanistic target of rapamycin kinase Homo sapiens 189-193 21606676-2 2011 One important strategy for stimulating protein synthesis involves the ser/thr kinase Akt, which subsequently triggers inactivation of the cap-dependent translational repressor 4E-BP1 by an mTOR-containing protein complex (mTORC1). cap 138-141 CREB regulated transcription coactivator 1 Mus musculus 222-228 21177195-5 2010 RESULTS: The MPO activity , which was similar between SAP group and CAP group at 1 h, were significantly lowered in CAP group at 6 and 12 h (P<0.05). cap 68-71 myeloperoxidase Rattus norvegicus 13-16 21520985-6 2011 Positive correlations were found for both KLK7 (Rs=0.74, P<0.001) and KLK11 (Rs=0.35, P=0.003) between CaP and BPH. cap 106-109 kallikrein related peptidase 7 Homo sapiens 42-46 21520985-6 2011 Positive correlations were found for both KLK7 (Rs=0.74, P<0.001) and KLK11 (Rs=0.35, P=0.003) between CaP and BPH. cap 106-109 kallikrein related peptidase 11 Homo sapiens 73-78 21486778-4 2011 Follow up studies revealed that overexpression of eIF2Bepsilon alone was sufficient to induce an 87% increase in cap-dependent translation in L6 myoblasts in vitro and 21% hypertrophy of myofibres in mouse skeletal muscle in vivo (P<0.05).However, genetically altering p70S6K activity had no impact on eIF2Bepsilon protein abundance in mouse skeletal muscle in vivo or multiple cell lines in vitro (P >0.05), suggesting that the two phenomena were not directly related. cap 113-116 eukaryotic translation initiation factor 2B subunit epsilon Homo sapiens 50-62 21486778-4 2011 Follow up studies revealed that overexpression of eIF2Bepsilon alone was sufficient to induce an 87% increase in cap-dependent translation in L6 myoblasts in vitro and 21% hypertrophy of myofibres in mouse skeletal muscle in vivo (P<0.05).However, genetically altering p70S6K activity had no impact on eIF2Bepsilon protein abundance in mouse skeletal muscle in vivo or multiple cell lines in vitro (P >0.05), suggesting that the two phenomena were not directly related. cap 113-116 ribosomal protein S6 kinase, polypeptide 1 Mus musculus 272-278 21486778-4 2011 Follow up studies revealed that overexpression of eIF2Bepsilon alone was sufficient to induce an 87% increase in cap-dependent translation in L6 myoblasts in vitro and 21% hypertrophy of myofibres in mouse skeletal muscle in vivo (P<0.05).However, genetically altering p70S6K activity had no impact on eIF2Bepsilon protein abundance in mouse skeletal muscle in vivo or multiple cell lines in vitro (P >0.05), suggesting that the two phenomena were not directly related. cap 113-116 eukaryotic translation initiation factor 2B subunit epsilon Homo sapiens 305-317 21536874-6 2011 Cap-ET-induced YO-PRO-1 transport required permeation of both the agonist and the dye through the TRPV1 pore and could be enhanced by kinase activation or oxidative covalent modification. cap 0-3 lamin A/C Homo sapiens 18-23 21536874-6 2011 Cap-ET-induced YO-PRO-1 transport required permeation of both the agonist and the dye through the TRPV1 pore and could be enhanced by kinase activation or oxidative covalent modification. cap 0-3 transient receptor potential cation channel subfamily V member 1 Homo sapiens 98-103 21075852-4 2011 IFNlambda-inducible phosphorylation/activation of RSK1 results in its dissociation from 4E-BP1 at the same time that 4E-BP1 dissociates from eIF4E to allow formation of eIF4F and initiation of cap-dependent translation. cap 193-196 ribosomal protein S6 kinase A1 Homo sapiens 50-54 21075852-4 2011 IFNlambda-inducible phosphorylation/activation of RSK1 results in its dissociation from 4E-BP1 at the same time that 4E-BP1 dissociates from eIF4E to allow formation of eIF4F and initiation of cap-dependent translation. cap 193-196 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 88-94 21075852-4 2011 IFNlambda-inducible phosphorylation/activation of RSK1 results in its dissociation from 4E-BP1 at the same time that 4E-BP1 dissociates from eIF4E to allow formation of eIF4F and initiation of cap-dependent translation. cap 193-196 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 117-123 21177195-6 2010 Serum amylase level and the levels of TNF-alpha and AngII in the lung tissue homogenate were all reduced significantly in CAP group as compared to those in SAP group (P<0.01). cap 122-125 tumor necrosis factor Rattus norvegicus 38-47 21177195-6 2010 Serum amylase level and the levels of TNF-alpha and AngII in the lung tissue homogenate were all reduced significantly in CAP group as compared to those in SAP group (P<0.01). cap 122-125 angiotensinogen Rattus norvegicus 52-57 20372058-2 2010 Here we show that 4E-BP1, one major repressor of cap-dependent translation, plays a critical role in density-mediated cell cycle arrest. cap 49-52 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 18-24 20736160-2 2010 Phosphorylation of 4E-BP1 regulates eIF4E availability, and therefore, cap-dependent translation, in cell stress. cap 71-74 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 19-25 20714220-2 2010 In addition to global downregulation of cap-dependent protein synthesis mediated by the GCN2 and mTORC1 signaling pathways, a catabolic process autophagy is upregulated to provide internal building blocks and energy needed to sustain viability. cap 40-43 eukaryotic translation initiation factor 2 alpha kinase 4 Homo sapiens 88-92 20714220-2 2010 In addition to global downregulation of cap-dependent protein synthesis mediated by the GCN2 and mTORC1 signaling pathways, a catabolic process autophagy is upregulated to provide internal building blocks and energy needed to sustain viability. cap 40-43 CREB regulated transcription coactivator 1 Mus musculus 97-103 20634900-6 2010 Here we report that IRES-mediated translation of both dFoxO and dInR is activated in fasted Drosophila S2 cells at a time when cap-dependent translation is reduced. cap 127-130 forkhead box, sub-group O Drosophila melanogaster 54-59 20634900-6 2010 Here we report that IRES-mediated translation of both dFoxO and dInR is activated in fasted Drosophila S2 cells at a time when cap-dependent translation is reduced. cap 127-130 Insulin-like receptor Drosophila melanogaster 64-68 20427534-0 2010 The virion host shutoff endonuclease (UL41) of herpes simplex virus interacts with the cellular cap-binding complex eIF4F. cap 96-99 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 116-121 20427534-5 2010 Here, we show that Vhs binds the cap-binding complex eIF4F. cap 33-36 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 53-58 20518521-0 2010 Disease-associated mutations in the p150(Glued) subunit destabilize the CAP-gly domain. cap 72-75 chromatin assembly factor 1 subunit A Homo sapiens 36-40 20436454-2 2010 Here, we identify a role of the Caenorhabditis elegans nuclear export receptor XPO-1 and the cap-binding proteins CBP-20/NCBP-2 and CBP-80/NCBP-1 in this process. cap 93-96 Nuclear cap-binding protein subunit 2 Caenorhabditis elegans 121-127 20436454-2 2010 Here, we identify a role of the Caenorhabditis elegans nuclear export receptor XPO-1 and the cap-binding proteins CBP-20/NCBP-2 and CBP-80/NCBP-1 in this process. cap 93-96 Nuclear cap-binding protein subunit 1 Caenorhabditis elegans 139-145 20190818-1 2010 The 5" untranslated region of the proto-oncogene c-myc contains an internal ribosome entry segment (IRES) and c-myc translation can therefore be initiated by internal ribosome entry as well as by cap-dependent mechanisms. cap 196-199 MYC proto-oncogene, bHLH transcription factor Homo sapiens 34-54 20190818-1 2010 The 5" untranslated region of the proto-oncogene c-myc contains an internal ribosome entry segment (IRES) and c-myc translation can therefore be initiated by internal ribosome entry as well as by cap-dependent mechanisms. cap 196-199 MYC proto-oncogene, bHLH transcription factor Homo sapiens 49-54 20679220-1 2010 MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) are protein-serine/threonine kinases that are activated by ERK or p38 and phosphorylate eIF4E, which is involved in cap-dependent translation initiation. cap 170-173 MAP kinase-interacting serine/threonine kinase 1 Mus musculus 39-43 20679220-1 2010 MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) are protein-serine/threonine kinases that are activated by ERK or p38 and phosphorylate eIF4E, which is involved in cap-dependent translation initiation. cap 170-173 MAP kinase-interacting serine/threonine kinase 2 Mus musculus 48-52 20679220-1 2010 MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) are protein-serine/threonine kinases that are activated by ERK or p38 and phosphorylate eIF4E, which is involved in cap-dependent translation initiation. cap 170-173 mitogen-activated protein kinase 14 Mus musculus 120-123 20679220-1 2010 MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) are protein-serine/threonine kinases that are activated by ERK or p38 and phosphorylate eIF4E, which is involved in cap-dependent translation initiation. cap 170-173 eukaryotic translation initiation factor 4E Mus musculus 142-147 20204449-8 2010 This is suppressed by ectopic PAC2 with both the CAP-Gly and UbL domains being essential. cap 49-52 Pac2p Saccharomyces cerevisiae S288C 30-34 20400847-3 2010 Such steady state localization for PABPN1 and PABPC1 led to a model whereby PABPN1-bound nuclear mRNAs are remodeled during or after nuclear export so that PABPN1 is replaced by PABPC1 to allow robust cap-dependent translation in the cytoplasm. cap 201-204 poly(A) binding protein nuclear 1 Homo sapiens 35-41 20400847-3 2010 Such steady state localization for PABPN1 and PABPC1 led to a model whereby PABPN1-bound nuclear mRNAs are remodeled during or after nuclear export so that PABPN1 is replaced by PABPC1 to allow robust cap-dependent translation in the cytoplasm. cap 201-204 poly(A) binding protein cytoplasmic 1 Homo sapiens 46-52 20400847-3 2010 Such steady state localization for PABPN1 and PABPC1 led to a model whereby PABPN1-bound nuclear mRNAs are remodeled during or after nuclear export so that PABPN1 is replaced by PABPC1 to allow robust cap-dependent translation in the cytoplasm. cap 201-204 poly(A) binding protein nuclear 1 Homo sapiens 76-82 20400847-3 2010 Such steady state localization for PABPN1 and PABPC1 led to a model whereby PABPN1-bound nuclear mRNAs are remodeled during or after nuclear export so that PABPN1 is replaced by PABPC1 to allow robust cap-dependent translation in the cytoplasm. cap 201-204 poly(A) binding protein nuclear 1 Homo sapiens 76-82 20400847-3 2010 Such steady state localization for PABPN1 and PABPC1 led to a model whereby PABPN1-bound nuclear mRNAs are remodeled during or after nuclear export so that PABPN1 is replaced by PABPC1 to allow robust cap-dependent translation in the cytoplasm. cap 201-204 poly(A) binding protein cytoplasmic 1 Homo sapiens 178-184 19864386-3 2010 Analyzing translation factors in herpes simplex virus type 1 (HSV-1)-infected HeLa cells, we found diminished association of the polyadenylate-binding protein (PABP) with the cap-binding complex. cap 175-178 poly(A) binding protein cytoplasmic 1 Homo sapiens 129-158 20227039-2 2010 While phosphorylation of rpS6 is dispensable for cancer formation, 4EBP-eIF4E exerts significant control over cap-dependent translation, cell growth, cancer initiation, and progression. cap 110-113 eukaryotic translation initiation factor 4E Homo sapiens 72-77 20028973-4 2010 The inhibition of cap-dependent translation by m(7)GDP in the cell-free translation system or induction of endoplasmic reticulum stress in hepatoma-derived cells resulted in stimulation of the c-Src IRES activities. cap 18-21 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 193-198 20133758-9 2010 We propose that pUL69 supports translation in human cytomegalovirus-infected cells by excluding hypophosphorylated 4EBP1 from the cap-binding complex. cap 130-133 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 115-120 19864386-3 2010 Analyzing translation factors in herpes simplex virus type 1 (HSV-1)-infected HeLa cells, we found diminished association of the polyadenylate-binding protein (PABP) with the cap-binding complex. cap 175-178 poly(A) binding protein cytoplasmic 1 Homo sapiens 160-164 19342890-5 2009 N has an activity that mimics or circumvents the cellular cap-binding complex, eIF4F, in the initial stages of translation initiation. cap 58-61 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 79-84 19603014-4 2009 In addition, cap-mediated translation was genetically repressed in these cells with a dominant active motive of 4E-BP1. cap 13-16 eukaryotic translation initiation factor 4E binding protein 1 Mus musculus 112-118 19713328-1 2009 X-chromosome linked inhibitor of apoptosis (XIAP) mRNA has been proposed to bear a stress-activated internal ribosome entry site (IRES) that stimulates translation under conditions that inhibit cap-dependent initiation. cap 194-197 X-linked inhibitor of apoptosis Homo sapiens 0-42 19713328-1 2009 X-chromosome linked inhibitor of apoptosis (XIAP) mRNA has been proposed to bear a stress-activated internal ribosome entry site (IRES) that stimulates translation under conditions that inhibit cap-dependent initiation. cap 194-197 X-linked inhibitor of apoptosis Homo sapiens 44-48 19501598-6 2009 Binding of this lead, 4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyridine, to wild-type p38alpha induces movement of the C-terminal cap region, creating a hydrophobic pocket centered around residue Trp197. cap 127-130 mitogen-activated protein kinase 14 Homo sapiens 83-91 17726024-6 2007 In contrast, Tyr(985) (the LepRb phosphorylation site required for ERK activation) mediates the phosphorylation of the ribosomal S6 kinase (RSK) and S6, as well as cap-dependent translation. cap 164-167 leptin receptor Mus musculus 27-32 19273599-6 2009 Furthermore, cap-dependent translation of p27 mRNA is repressed by miR-181a in undifferentiated HL60 cells. cap 13-16 interferon alpha inducible protein 27 Homo sapiens 42-45 19297618-2 2009 We have identified the BASP1 (CAP-23, NAP-22) gene as a novel target suppressed by Myc. cap 30-33 brain abundant, membrane attached signal protein 1 Rattus norvegicus 23-28 19297618-2 2009 We have identified the BASP1 (CAP-23, NAP-22) gene as a novel target suppressed by Myc. cap 30-33 brain abundant, membrane attached signal protein 1 Rattus norvegicus 38-44 19297618-2 2009 We have identified the BASP1 (CAP-23, NAP-22) gene as a novel target suppressed by Myc. cap 30-33 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 83-86 19101615-3 2009 In order to identify novel factors that might act at the translational level during Drosophila oogenesis, we have undertaken a functional proteomic approach and isolated the product of the Hsp83 gene, the evolutionarily conserved chaperone Hsp90, as a specific component of the cap-binding complex. cap 278-281 Heat shock protein 83 Drosophila melanogaster 189-194 19101615-3 2009 In order to identify novel factors that might act at the translational level during Drosophila oogenesis, we have undertaken a functional proteomic approach and isolated the product of the Hsp83 gene, the evolutionarily conserved chaperone Hsp90, as a specific component of the cap-binding complex. cap 278-281 Heat shock protein 83 Drosophila melanogaster 240-245 19101564-7 2009 Based on our mutational and analog studies, the guanine ring and alpha-phosphate interactions provide most of the energy for cap binding, while the combination of the water bridge between the guanine N1 and Leu19 carbonyl and the hydrogen bonds between the C2 amine and Leu16/Leu19 carbonyl groups provide for specific guanine recognition. cap 125-128 membrane spanning 4-domains A1 Homo sapiens 270-275 18438920-1 2008 The brain acid-soluble protein BASP1 (CAP-23, NAP-22) belongs to the family of growth-associated proteins, which also includes GAP-43, a protein recently shown to regulate neural cell adhesion molecule (NCAM)-mediated neurite outgrowth. cap 38-41 brain abundant, membrane attached signal protein 1 Rattus norvegicus 31-36 18438920-1 2008 The brain acid-soluble protein BASP1 (CAP-23, NAP-22) belongs to the family of growth-associated proteins, which also includes GAP-43, a protein recently shown to regulate neural cell adhesion molecule (NCAM)-mediated neurite outgrowth. cap 38-41 brain abundant, membrane attached signal protein 1 Rattus norvegicus 46-52 18438920-1 2008 The brain acid-soluble protein BASP1 (CAP-23, NAP-22) belongs to the family of growth-associated proteins, which also includes GAP-43, a protein recently shown to regulate neural cell adhesion molecule (NCAM)-mediated neurite outgrowth. cap 38-41 growth associated protein 43 Rattus norvegicus 127-133 18438920-1 2008 The brain acid-soluble protein BASP1 (CAP-23, NAP-22) belongs to the family of growth-associated proteins, which also includes GAP-43, a protein recently shown to regulate neural cell adhesion molecule (NCAM)-mediated neurite outgrowth. cap 38-41 neural cell adhesion molecule 1 Rattus norvegicus 172-201 18438920-1 2008 The brain acid-soluble protein BASP1 (CAP-23, NAP-22) belongs to the family of growth-associated proteins, which also includes GAP-43, a protein recently shown to regulate neural cell adhesion molecule (NCAM)-mediated neurite outgrowth. cap 38-41 neural cell adhesion molecule 1 Rattus norvegicus 203-207 17897889-3 2008 After 24h of CAP and 30 min after SP and NKA infusions there was an increase in nNOS-positive eosinophils and mononuclear cells compared to controls (P<0.05). cap 13-16 nitric oxide synthase, brain Cavia porcellus 80-84 17996713-4 2007 Using model animal and cell studies, we then show that overexpressed 4E-BP1 and eIF4G orchestrate a hypoxia-activated switch from cap-dependent to cap-independent mRNA translation that promotes increased tumor angiogenesis and growth at the level of selective mRNA translation. cap 130-133 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 69-75 17996713-4 2007 Using model animal and cell studies, we then show that overexpressed 4E-BP1 and eIF4G orchestrate a hypoxia-activated switch from cap-dependent to cap-independent mRNA translation that promotes increased tumor angiogenesis and growth at the level of selective mRNA translation. cap 130-133 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 80-85 19159466-3 2009 1 describes an MC sequence region identified in Ago2 that displays similarity to the cap-binding motif in translation initiation factor 4E (eIF4E). cap 85-88 argonaute RISC catalytic component 2 Homo sapiens 48-52 19159466-3 2009 1 describes an MC sequence region identified in Ago2 that displays similarity to the cap-binding motif in translation initiation factor 4E (eIF4E). cap 85-88 eukaryotic translation initiation factor 4E Homo sapiens 140-145 19159466-5 2009 The corresponding Ago2 aromatic residues (F450 and F505) were hypothesized to perform the same cap-binding function. cap 95-98 argonaute RISC catalytic component 2 Homo sapiens 18-22 18451872-1 2008 During mammalian programmed cell death, cleavage of the translation initiation factor 4G proteins (eIF4GI and eIF4GII) by caspase-3 induces the cap-independent synthesis of pro-apoptotic proteins. cap 144-147 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 99-105 18451872-1 2008 During mammalian programmed cell death, cleavage of the translation initiation factor 4G proteins (eIF4GI and eIF4GII) by caspase-3 induces the cap-independent synthesis of pro-apoptotic proteins. cap 144-147 eukaryotic translation initiation factor 4 gamma 3 Homo sapiens 110-117 18451872-1 2008 During mammalian programmed cell death, cleavage of the translation initiation factor 4G proteins (eIF4GI and eIF4GII) by caspase-3 induces the cap-independent synthesis of pro-apoptotic proteins. cap 144-147 caspase 3 Homo sapiens 122-131 18343217-4 2008 Here, we show that overexpression of eIF4E-T preferentially inhibits cap-dependent steady-state translation, but not the pioneer round of translation. cap 69-72 eukaryotic translation initiation factor 4E Homo sapiens 37-42 18222923-1 2008 The familial cylindromatosis tumor suppressor CYLD is known to contain three cytoskeleton-associated protein glycine-rich (CAP-Gly) domains, which exist in a number of microtubule-binding proteins and are responsible for their association with microtubules. cap 123-126 CYLD lysine 63 deubiquitinase Homo sapiens 46-50 18220364-5 2008 Hydrogen-deuterium exchange and electrospray mass spectrometry were applied to probe local dynamics of murine eIF4E in the apo and cap-bound forms. cap 131-134 eukaryotic translation initiation factor 4E Mus musculus 110-115 18637511-5 2008 This chapter will focus on the mechanisms by which cap-dependent translation is maintained during HCMV infection through alterations of the phosphatidylinositol-3" kinase (PI3K)-Akt-tuberous sclerosis complex (TSC)-mammalian target of rapamycin (mTOR) signaling pathway. cap 51-54 mechanistic target of rapamycin kinase Homo sapiens 215-244 18637511-5 2008 This chapter will focus on the mechanisms by which cap-dependent translation is maintained during HCMV infection through alterations of the phosphatidylinositol-3" kinase (PI3K)-Akt-tuberous sclerosis complex (TSC)-mammalian target of rapamycin (mTOR) signaling pathway. cap 51-54 mechanistic target of rapamycin kinase Homo sapiens 246-250 17728788-9 2007 Individuals with -173G/C, -173C/C and -794 7-CATT MIF genotypes have an increased incidence of CaP and these genotypes may serve as an independent marker for cancer recurrence. cap 95-98 macrophage migration inhibitory factor Homo sapiens 50-53 17638893-1 2007 Pathologic redirection of translational control by constitutive activation of eukaryotic translation initiation factor 4F (eIF4F), the cap-dependent translation initiation apparatus, is an obligatory step in oncogenesis; however, its mechanism remains undefined. cap 135-138 eukaryotic translation initiation factor 4E Homo sapiens 78-121 17638893-1 2007 Pathologic redirection of translational control by constitutive activation of eukaryotic translation initiation factor 4F (eIF4F), the cap-dependent translation initiation apparatus, is an obligatory step in oncogenesis; however, its mechanism remains undefined. cap 135-138 eukaryotic translation initiation factor 4E Homo sapiens 123-128 17368478-12 2007 Overall the data, combined with sequence analyses of 4EHP from evolutionary diverse species, strongly support the hypothesis that 4EHP plays a physiological role utilizing both cap-binding and protein-binding functions but which is distinct from eIF4E. cap 177-180 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 130-134 17584618-1 2007 Central to cap-dependent eukaryotic translation initiation is the eIF4F complex, which is composed of the three eukaryotic initiation factors eIF4E, eIF4G, and eIF4A. cap 11-14 eukaryotic translation initiation factor 4E Homo sapiens 142-147 17584618-1 2007 Central to cap-dependent eukaryotic translation initiation is the eIF4F complex, which is composed of the three eukaryotic initiation factors eIF4E, eIF4G, and eIF4A. cap 11-14 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 149-154 17584618-1 2007 Central to cap-dependent eukaryotic translation initiation is the eIF4F complex, which is composed of the three eukaryotic initiation factors eIF4E, eIF4G, and eIF4A. cap 11-14 eukaryotic translation initiation factor 4A1 Homo sapiens 160-165 17334246-14 2007 CONCLUSIONS: HMGB1 is elevated in almost all CAP subjects, and higher circulating HMGB1 is associated with mortality. cap 45-48 high mobility group box 1 Homo sapiens 13-18 17369309-5 2007 We show that 4EHP binds cap analogs m(7)GpppG and m(7)GTP with 30 and 100 lower affinity than eIF4E. cap 24-27 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 13-17 17369309-5 2007 We show that 4EHP binds cap analogs m(7)GpppG and m(7)GTP with 30 and 100 lower affinity than eIF4E. cap 24-27 eukaryotic translation initiation factor 4E Homo sapiens 94-99 17440067-7 2007 These results indicate that PEITC modulates availability of eIF4E for translation initiation leading to inhibition of cap-dependent translation. cap 118-121 eukaryotic translation initiation factor 4E Homo sapiens 60-65 17220299-7 2007 Trx1 facilitated synthesis of HIF-1alpha by activating Akt, p70S6K, and eIF-4E, known to control cap-dependent translation. cap 97-100 thioredoxin Homo sapiens 0-4 17284439-3 2007 We report here that the 518-nt long 5"-untranslated region (5"-UTR) of the GATA-4 mRNA, which is predicted to form stable secondary structures (-65 kcal/mol) such as to be inhibitory to cap-dependent initiation, confers efficient translation to monocistronic reporter mRNAs in cell-free extracts. cap 186-189 GATA binding protein 4 Mus musculus 75-81 17220299-7 2007 Trx1 facilitated synthesis of HIF-1alpha by activating Akt, p70S6K, and eIF-4E, known to control cap-dependent translation. cap 97-100 hypoxia inducible factor 1 subunit alpha Homo sapiens 30-40 17220299-7 2007 Trx1 facilitated synthesis of HIF-1alpha by activating Akt, p70S6K, and eIF-4E, known to control cap-dependent translation. cap 97-100 AKT serine/threonine kinase 1 Homo sapiens 55-58 17220299-7 2007 Trx1 facilitated synthesis of HIF-1alpha by activating Akt, p70S6K, and eIF-4E, known to control cap-dependent translation. cap 97-100 eukaryotic translation initiation factor 4E Homo sapiens 72-78 16439989-2 2006 Within 10 min of ischemia, eukaryotic (eIF)4E binds to its negative regulator, eIF4E-binding protein-1 (4E-BP1), but the levels of 4E-BP1 are insufficient to disrupt cap-dependent mRNA initiation complexes. cap 166-169 eukaryotic translation initiation factor 4E Rattus norvegicus 39-45 17316629-2 2007 During mRNA translation, eIF4E provides the cap-binding function and is associated with the protein eIF4G to form the eIF4F complex. cap 44-47 eukaryotic translation initiation factor 4E Arabidopsis thaliana 25-30 17235019-8 2007 The genetic correlations between CaP and ADG, CWT, LMA, RT, SFT, and MS were 0.19, 0.14, 0.30, 0.38, -0.11, and 0.98, respectively. cap 33-36 ADG Bos taurus 41-44 17036047-3 2006 Further, cap binding substantially modulates eIF4E"s affinity for eIF4G and the 4E-BPs. cap 9-12 eukaryotic translation initiation factor 4E Homo sapiens 45-50 17036047-3 2006 Further, cap binding substantially modulates eIF4E"s affinity for eIF4G and the 4E-BPs. cap 9-12 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 66-71 16439989-3 2006 However, by 1 h of ischemia, the abundance of the cap-initiation complex protein eIF4G is reduced by relocalization into TIAR protein complexes, triggering 4E-BP1 sequestration of eIF4E and disruption of cap-dependent mRNA initiation complexes. cap 50-53 eukaryotic translation initiation factor 4 gamma 1 Rattus norvegicus 81-86 16439989-3 2006 However, by 1 h of ischemia, the abundance of the cap-initiation complex protein eIF4G is reduced by relocalization into TIAR protein complexes, triggering 4E-BP1 sequestration of eIF4E and disruption of cap-dependent mRNA initiation complexes. cap 50-53 eukaryotic translation initiation factor 4E binding protein 1 Rattus norvegicus 156-162 16439989-3 2006 However, by 1 h of ischemia, the abundance of the cap-initiation complex protein eIF4G is reduced by relocalization into TIAR protein complexes, triggering 4E-BP1 sequestration of eIF4E and disruption of cap-dependent mRNA initiation complexes. cap 50-53 eukaryotic translation initiation factor 4E Rattus norvegicus 180-185 16439989-6 2006 Acute heart ischemia therefore downregulates cap-dependent translation through eIF4E sequestration triggered by eIF4G depletion. cap 45-48 eukaryotic translation initiation factor 4E Rattus norvegicus 79-84 16439989-6 2006 Acute heart ischemia therefore downregulates cap-dependent translation through eIF4E sequestration triggered by eIF4G depletion. cap 45-48 eukaryotic translation initiation factor 4 gamma 1 Rattus norvegicus 112-117 16626853-4 2006 VPg/eIF4E interaction results in the inhibition of cell-free protein synthesis, and we show that it stems from the liberation of the cap moiety from the complex with eIF4E. cap 133-136 eukaryotic translation initiation factor 4E Homo sapiens 4-9 16832048-1 2006 We previously demonstrated that mRNAs retained in the nucleus of Saccharomyces cerevisiae are subjected to a degradation system-designated DRN (degradation of mRNA in the nucleus), that is diminished in cbc1-Delta or cbc2-Delta mutants lacking components of the cap-binding complex and in rrp6-Delta mutants lacking Rrp6p, a 3" to 5" nuclear exonuclease. cap 262-265 Sto1p Saccharomyces cerevisiae S288C 203-207 16832048-1 2006 We previously demonstrated that mRNAs retained in the nucleus of Saccharomyces cerevisiae are subjected to a degradation system-designated DRN (degradation of mRNA in the nucleus), that is diminished in cbc1-Delta or cbc2-Delta mutants lacking components of the cap-binding complex and in rrp6-Delta mutants lacking Rrp6p, a 3" to 5" nuclear exonuclease. cap 262-265 nuclear cap-binding protein subunit CBC2 Saccharomyces cerevisiae S288C 217-221 16626853-4 2006 VPg/eIF4E interaction results in the inhibition of cell-free protein synthesis, and we show that it stems from the liberation of the cap moiety from the complex with eIF4E. cap 133-136 eukaryotic translation initiation factor 4E Homo sapiens 166-171 16531451-7 2006 Looking for an upstream determinant of translational deregulation, we found an increase in the hyperphosphorylated form of the 4E-BP1 protein in the metastatic cell line, possibly resulting in an increased activation of cap-dependent translation due to increased activity of the eIF4E protein. cap 220-223 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 127-133 16531451-7 2006 Looking for an upstream determinant of translational deregulation, we found an increase in the hyperphosphorylated form of the 4E-BP1 protein in the metastatic cell line, possibly resulting in an increased activation of cap-dependent translation due to increased activity of the eIF4E protein. cap 220-223 eukaryotic translation initiation factor 4E Homo sapiens 279-284 15890927-2 2005 The hypophosphorylation of 4E-BP1 results in 4E-BP1 binding to eIF4E, leading to the inhibition of cap-dependent translation. cap 99-102 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 27-33 16515558-0 2006 Mnk is a negative regulator of cap-dependent translation in Aplysia neurons. cap 31-34 ATPase copper transporting alpha Homo sapiens 0-3 16515558-8 2006 We propose that changes in eIF4E phosphorylation in Aplysia neurons are a consequence of changes in cap-dependent translation that are independent of regulation of Aplysia Mnk. cap 100-103 eukaryotic translation initiation factor 4E Homo sapiens 27-32 16613100-5 2006 RESULTS: At early stages and height of CAP exacerbation, concentrations of IL-1beta, IL-6, IL-8, TNF-gamma and TNFalpha were elevated (951.1 +/- 104.2 pg/ml; 172.8 +/- 24.3 pg/ml; 432.6 +/- 68.5 pg/ml; 823.3 +/- 97.5 pg/ml; 158.7 +/- 19.6 pg/ml, respectively). cap 39-42 interleukin 1 beta Homo sapiens 75-83 16613100-5 2006 RESULTS: At early stages and height of CAP exacerbation, concentrations of IL-1beta, IL-6, IL-8, TNF-gamma and TNFalpha were elevated (951.1 +/- 104.2 pg/ml; 172.8 +/- 24.3 pg/ml; 432.6 +/- 68.5 pg/ml; 823.3 +/- 97.5 pg/ml; 158.7 +/- 19.6 pg/ml, respectively). cap 39-42 tumor necrosis factor Homo sapiens 97-119 16281055-0 2005 Inhibition of cap-dependent translation via phosphorylation of eIF4G by protein kinase Pak2. cap 14-17 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 63-68 16281055-0 2005 Inhibition of cap-dependent translation via phosphorylation of eIF4G by protein kinase Pak2. cap 14-17 p21 (RAC1) activated kinase 2 Homo sapiens 87-91 16174738-6 2005 In striking contrast to cap-dependent translation, c-myc IRES-dependent translation is fully restored by addition of the conserved middle fragment of eIF4GI, harboring the eIF3- and eIF4A-binding sites. cap 24-27 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 150-156 15901615-4 2005 In the present study, we hypothesized that phosphorylation of eukaryotic initiation factor-4E (eIF4E)-binding protein (4E-BP), which subsequently releases eIF4E and initiates cap-dependent mRNA translation, was required for airway smooth muscle hypertrophy. cap 175-178 eukaryotic translation initiation factor 4E Homo sapiens 62-93 15901615-4 2005 In the present study, we hypothesized that phosphorylation of eukaryotic initiation factor-4E (eIF4E)-binding protein (4E-BP), which subsequently releases eIF4E and initiates cap-dependent mRNA translation, was required for airway smooth muscle hypertrophy. cap 175-178 eukaryotic translation initiation factor 4E Homo sapiens 95-100 15901615-4 2005 In the present study, we hypothesized that phosphorylation of eukaryotic initiation factor-4E (eIF4E)-binding protein (4E-BP), which subsequently releases eIF4E and initiates cap-dependent mRNA translation, was required for airway smooth muscle hypertrophy. cap 175-178 eukaryotic translation initiation factor 4E Homo sapiens 155-160 16800741-6 2006 Logistic regression and receiver operating characteristic curve analyses demonstrated that KLK11 expression has a significant discriminatory value (crude odds ratio=3.84, p=0.016; area under the curve, 0.65, 95% CI 0.51-0.80) between CaP and BPH in needle prostate biopsies. cap 234-237 kallikrein related peptidase 11 Homo sapiens 91-96 16556598-9 2006 Instead, we identify PKCalpha as a novel repressor of cyclin D1 translation, acting at the level of cap-dependent initiation. cap 100-103 protein kinase C alpha Homo sapiens 21-29 16556598-9 2006 Instead, we identify PKCalpha as a novel repressor of cyclin D1 translation, acting at the level of cap-dependent initiation. cap 100-103 cyclin D1 Homo sapiens 54-63 16405910-5 2006 Binding of eIF4G to apo-eIF4E likewise induces folding of the protein into a state that is similar to, but not identical with, that of cap-bound eIF4E. cap 135-138 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 11-16 16405910-5 2006 Binding of eIF4G to apo-eIF4E likewise induces folding of the protein into a state that is similar to, but not identical with, that of cap-bound eIF4E. cap 135-138 eukaryotic translation initiation factor 4E Homo sapiens 24-29 16405910-5 2006 Binding of eIF4G to apo-eIF4E likewise induces folding of the protein into a state that is similar to, but not identical with, that of cap-bound eIF4E. cap 135-138 eukaryotic translation initiation factor 4E Homo sapiens 145-150 16898492-12 2006 In patients with higher PTH level (> 200 pg/ml) the higher correlations between OPG and PTH, CAP and CIP were found. cap 96-99 TNF receptor superfamily member 11b Homo sapiens 83-86 15890927-2 2005 The hypophosphorylation of 4E-BP1 results in 4E-BP1 binding to eIF4E, leading to the inhibition of cap-dependent translation. cap 99-102 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 45-51 16029630-2 2005 METHODS: PCR was used to examine the A49T polymorphisms of SRD5A2 gene in the tissues of prostate cancer resected from 112 patients (CaP group) and the specimens of benign prostate hyperplasia (BPH group) resected from 89 patients. cap 133-136 steroid 5 alpha-reductase 2 Homo sapiens 59-65 15491137-4 2004 A nontrivial, statistically important isothermal enthalpy-entropy compensation has been detected (T(c) = 399 +/- 24 K), which points to significant fluctuations of apo-eIF4E and indicates that the cap-binding microstate lies 9.66 +/- 1.7 kJ mol(-1) below the mean energy of all available conformational states. cap 197-200 eukaryotic translation initiation factor 4E Homo sapiens 168-173 15855503-1 2005 The combination of two candidate microbicides, cellulose acetate 1,2-benzenedicarboxylate (CAP), a polymer that blocks human immunodeficiency virus type 1 (HIV-1) entry by targeting gp120 and gp41, and UC781, a tight-binding HIV-1 reverse transcriptase inhibitor (RTI), resulted in effective synergy for inhibition of MT-2 cell infection by HIV-1(IIIB), a laboratory-adapted virus strain. cap 91-94 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 182-187 15766285-4 2005 The temperature-dependent K(d) values for cap analogues were markedly lower, indicating tighter binding, with the eIF4E(K119A) mutant compared with wild-type eIF4E. cap 42-45 eukaryotic translation initiation factor 4E Homo sapiens 114-119 15766285-4 2005 The temperature-dependent K(d) values for cap analogues were markedly lower, indicating tighter binding, with the eIF4E(K119A) mutant compared with wild-type eIF4E. cap 42-45 eukaryotic translation initiation factor 4E Homo sapiens 158-163 15388875-0 2004 Cap-binding activity of an eIF4E homolog from Leishmania. cap 0-3 eukaryotic translation initiation factor 4E Mus musculus 27-32 15631341-8 2004 In whole group of patients iPTH, CAP, CIP but not CAP/CIP correlated negatively with OPGL and OPGL/OPG as well as positively with dialysis duration, OPG and AP. cap 33-36 TNF superfamily member 11 Homo sapiens 85-89 15341735-0 2004 The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma. cap 4-7 CYLD lysine 63 deubiquitinase Homo sapiens 22-26 15341735-0 2004 The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma. cap 4-7 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 72-76 15341735-0 2004 The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma. cap 4-7 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 77-85 15341735-3 2004 The two proteins bind to a region of CYLD that contains a Cys-box motif and the third cytoskeleton-associated protein-glycine conserved (CAP-Gly) domain. cap 137-140 CYLD lysine 63 deubiquitinase Homo sapiens 37-41 15220445-3 2004 Cap-dependent mRNA translation generally correlates with Mnk1 phosphorylation of eIF4E when both are bound to eIF4G. cap 0-3 MAPK interacting serine/threonine kinase 1 Homo sapiens 57-61 15220445-3 2004 Cap-dependent mRNA translation generally correlates with Mnk1 phosphorylation of eIF4E when both are bound to eIF4G. cap 0-3 eukaryotic translation initiation factor 4E Homo sapiens 81-86 15220445-3 2004 Cap-dependent mRNA translation generally correlates with Mnk1 phosphorylation of eIF4E when both are bound to eIF4G. cap 0-3 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 110-115 15220445-6 2004 The eIF4G-binding site is located in an N-terminal 66-amino-acid peptide of 100K which is sufficient to bind eIF4G, displace Mnk1, block eIF4E phosphorylation, and inhibit eIF4F (cap)-dependent cellular mRNA translation. cap 179-182 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 4-9 15220445-6 2004 The eIF4G-binding site is located in an N-terminal 66-amino-acid peptide of 100K which is sufficient to bind eIF4G, displace Mnk1, block eIF4E phosphorylation, and inhibit eIF4F (cap)-dependent cellular mRNA translation. cap 179-182 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 109-114 15220445-6 2004 The eIF4G-binding site is located in an N-terminal 66-amino-acid peptide of 100K which is sufficient to bind eIF4G, displace Mnk1, block eIF4E phosphorylation, and inhibit eIF4F (cap)-dependent cellular mRNA translation. cap 179-182 MAPK interacting serine/threonine kinase 1 Homo sapiens 125-129 15220445-6 2004 The eIF4G-binding site is located in an N-terminal 66-amino-acid peptide of 100K which is sufficient to bind eIF4G, displace Mnk1, block eIF4E phosphorylation, and inhibit eIF4F (cap)-dependent cellular mRNA translation. cap 179-182 eukaryotic translation initiation factor 4E Homo sapiens 137-142 15220445-6 2004 The eIF4G-binding site is located in an N-terminal 66-amino-acid peptide of 100K which is sufficient to bind eIF4G, displace Mnk1, block eIF4E phosphorylation, and inhibit eIF4F (cap)-dependent cellular mRNA translation. cap 179-182 eukaryotic translation initiation factor 4E Homo sapiens 172-177 15262990-0 2004 CLIPR-59 is a lipid raft-associated protein containing a cytoskeleton-associated protein glycine-rich domain (CAP-Gly) that perturbs microtubule dynamics. cap 110-113 CAP-Gly domain containing linker protein 3 Homo sapiens 0-8 15123638-8 2004 Thus, the IRES-mediated translation of BCL-2 may enable the cell to replenish levels of this critical protein during cell stress, when cap-dependent translation is repressed, thereby maintaining the balance between pro- and anti-apoptotic BCL-2 family members in the cell and preventing unwarranted induction of apoptosis. cap 135-138 BCL2 apoptosis regulator Homo sapiens 39-44 15068932-11 2004 Moreover, IL-6 protein in BAL increasing with CAP levels (P<0.05, test for trend) was demonstrated. cap 46-49 interleukin 6 Rattus norvegicus 10-14 12532111-9 2003 Specific IgE of > or =CAP class 2 was 87.5% predictive for allergy development, whereas a negative conjunctival provocation test result was 100% negatively predictive. cap 25-28 immunoglobulin heavy constant epsilon Homo sapiens 9-12 14507920-1 2003 Insulin stimulates phosphorylation of multiple sites in the eIF4E-binding protein, PHAS-I, leading to dissociation of the PHAS-I.eIF4E complex and to an increase in cap-dependent translation. cap 165-168 insulin Homo sapiens 0-7 14507920-1 2003 Insulin stimulates phosphorylation of multiple sites in the eIF4E-binding protein, PHAS-I, leading to dissociation of the PHAS-I.eIF4E complex and to an increase in cap-dependent translation. cap 165-168 eukaryotic translation initiation factor 4E Homo sapiens 60-65 14507920-1 2003 Insulin stimulates phosphorylation of multiple sites in the eIF4E-binding protein, PHAS-I, leading to dissociation of the PHAS-I.eIF4E complex and to an increase in cap-dependent translation. cap 165-168 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 83-89 14507920-1 2003 Insulin stimulates phosphorylation of multiple sites in the eIF4E-binding protein, PHAS-I, leading to dissociation of the PHAS-I.eIF4E complex and to an increase in cap-dependent translation. cap 165-168 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 122-128 12755433-4 2003 Therefore, a new 3rd generation PTH assay that detects only the whole PTH molecule (W-PTH; cyclase-activating PTH [CAP]) has been developed. cap 115-118 parathyroid hormone Equus caballus 32-35 14690557-1 2003 OBJECTIVE: To determine whether the eukaryotic initiation factor-4E (eIF-4E) is involved in the cap-dependent translational regulation of heparanase and study the correlation between heparanase expression and metastatic potential of LS-174T cells. cap 96-99 eukaryotic translation initiation factor 4E Homo sapiens 36-67 14690557-1 2003 OBJECTIVE: To determine whether the eukaryotic initiation factor-4E (eIF-4E) is involved in the cap-dependent translational regulation of heparanase and study the correlation between heparanase expression and metastatic potential of LS-174T cells. cap 96-99 eukaryotic translation initiation factor 4E Homo sapiens 69-75 12691746-9 2003 SDS-PAGE analyses showed that this structural instability is highly related to the fast degradation of cap-free eIF4E, compared with cap-bound or 4E-BP/cap-bound eIF4E, indicating the conferment of structural stability of eIF4E by the binary or ternary complex formation. cap 103-106 eukaryotic translation initiation factor 4E Homo sapiens 112-117 12845234-9 2003 The serum CAP levels significantly correlated with that of i-PTH (r = 0.959, p < 0.001). cap 10-13 parathyroid hormone Homo sapiens 61-64 12845234-10 2003 Moreover, a significant positive correlation between serum CAP levels and metabolic bone markers such as BAP (r = 0.400, p < 0.01) and BGP (r = 0.481, p < 0.01) was observed. cap 59-62 bone gamma-carboxyglutamate protein Homo sapiens 138-141 12374755-3 2002 Comparison with the structure of uncomplexed CBC shows that cap binding induces co-operative folding around the dinucleotide of some 50 residues from the N- and C-terminal extensions to the central RNP domain of the small subunit CBP20. cap 60-63 nuclear cap binding protein subunit 2 Homo sapiens 230-235 12167703-7 2002 However, the IRES activity of the 5" UTR of PKCdelta is not enhanced during serum starvation, another condition shown to inhibit cap-dependent translation, suggesting that its potency is dependent on specific cellular conditions. cap 129-132 protein kinase C delta type Oryctolagus cuniculus 44-52 11513750-1 2001 The eukaryotic initiation factor 4E (eIF4E) binding protein (4E-BP1) interacts directly with eIF4E and prevents it from forming initiation factor (eIF4F) complexes required for the initiation of cap-dependent mRNA translation. cap 195-198 eukaryotic translation initiation factor 4E Homo sapiens 4-35 12123581-7 2002 The LSP1 locus was isolated by map-based cloning and was identified as the gene encoding translation factor eIF(iso)4E, one of several known Arabidopsis isoforms that has cap binding activity. cap 171-174 Eukaryotic initiation factor 4E protein Arabidopsis thaliana 4-8 12021326-9 2002 Interestingly, there was a transient increase in the amount of phosphorylation of the translation initiation factor 4E (eIF4E) in infected cells, and this eIF4E phosphorylation was p38 MAPK dependent; it is known that phosphorylated eIF4E enhances translation rates of cap-containing mRNAs. cap 269-272 mitogen-activated protein kinase 14 Mus musculus 181-189 11909977-9 2002 These findings show: that phosphorylation events govern the proapoptotic potency of 4E-BP1, that 4E-BP1 is proapoptotic in normal as well as transformed fibroblasts, and that malignant transformation is associated with a higher requirement for cap-dependent translation to inhibit apoptosis. cap 244-247 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 97-103 11777913-1 2002 In resting cells, eIF4E-binding protein 1 (4E-BP1) binds to the eukaryotic initiation factor-4E (eIF-4E), preventing formation of a functional eIF-4F complex essential for cap-dependent initiation of translation. cap 172-175 eukaryotic translation initiation factor 4E binding protein 1 Mus musculus 18-41 11777913-1 2002 In resting cells, eIF4E-binding protein 1 (4E-BP1) binds to the eukaryotic initiation factor-4E (eIF-4E), preventing formation of a functional eIF-4F complex essential for cap-dependent initiation of translation. cap 172-175 eukaryotic translation initiation factor 4E binding protein 1 Mus musculus 43-49 11777913-1 2002 In resting cells, eIF4E-binding protein 1 (4E-BP1) binds to the eukaryotic initiation factor-4E (eIF-4E), preventing formation of a functional eIF-4F complex essential for cap-dependent initiation of translation. cap 172-175 eukaryotic translation initiation factor 4E Mus musculus 64-95 11777913-1 2002 In resting cells, eIF4E-binding protein 1 (4E-BP1) binds to the eukaryotic initiation factor-4E (eIF-4E), preventing formation of a functional eIF-4F complex essential for cap-dependent initiation of translation. cap 172-175 eukaryotic translation initiation factor 4E Mus musculus 97-103 11513750-1 2001 The eukaryotic initiation factor 4E (eIF4E) binding protein (4E-BP1) interacts directly with eIF4E and prevents it from forming initiation factor (eIF4F) complexes required for the initiation of cap-dependent mRNA translation. cap 195-198 neuroguidin Homo sapiens 37-59 11513750-1 2001 The eukaryotic initiation factor 4E (eIF4E) binding protein (4E-BP1) interacts directly with eIF4E and prevents it from forming initiation factor (eIF4F) complexes required for the initiation of cap-dependent mRNA translation. cap 195-198 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 61-67 11513750-1 2001 The eukaryotic initiation factor 4E (eIF4E) binding protein (4E-BP1) interacts directly with eIF4E and prevents it from forming initiation factor (eIF4F) complexes required for the initiation of cap-dependent mRNA translation. cap 195-198 eukaryotic translation initiation factor 4E Homo sapiens 37-42 11513750-1 2001 The eukaryotic initiation factor 4E (eIF4E) binding protein (4E-BP1) interacts directly with eIF4E and prevents it from forming initiation factor (eIF4F) complexes required for the initiation of cap-dependent mRNA translation. cap 195-198 eukaryotic translation initiation factor 4E Homo sapiens 147-152 12536625-9 2001 In CAP group, HSP70 expression was higher than that in control group. cap 3-6 heat shock protein family A (Hsp70) member 4 Homo sapiens 14-19 11463832-9 2001 Instead, we propose that the kinase activity of MNKs, eventually through phosphorylation of eIF4E, may serve to limit cap-dependent translation under physiological conditions. cap 118-121 eukaryotic translation initiation factor 4E Homo sapiens 92-97 11337316-8 2001 RESULTS: Thirty-two of 95 patients with CaP (35%) had at least one positive molecular margin indicating an expression for PSA; 19 of 48 (39%) of these had an organ-confined tumor stage according to conventional histology and 13 of 47 (28%) had tumor growth beyond the prostate. cap 40-43 kallikrein related peptidase 3 Homo sapiens 122-125 11483729-5 2001 Thus, initiation on the HAV IRES requires that eIF4E be associated with eIF4G and that the cap-binding pocket of eIF4E be empty and unoccupied. cap 91-94 eukaryotic translation initiation factor 4E Homo sapiens 113-118 11309621-0 2001 Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. cap 52-55 insulin Homo sapiens 0-7 11309621-0 2001 Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. cap 52-55 solute carrier family 2 member 4 Homo sapiens 19-24 11309621-0 2001 Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. cap 52-55 ras homolog family member Q Homo sapiens 80-84 10765078-6 2000 RESULTS: Percent free PSA was more effective than total PSA in differential diagnosis between CaP and BPH in every evaluated dose range of total PSA. cap 94-97 kallikrein related peptidase 3 Homo sapiens 22-25 10823828-0 2000 7The yeast mRNA-binding protein Npl3p interacts with the cap-binding complex. cap 57-60 mRNA-binding protein NPL3 Saccharomyces cerevisiae S288C 32-37 10823828-4 2000 In this report, we define a genetic relationship between NPL3 and the nonessential genes encoding the subunits of the cap-binding complex (CBP80 and CBP20). cap 118-121 mRNA-binding protein NPL3 Saccharomyces cerevisiae S288C 57-61 10823828-4 2000 In this report, we define a genetic relationship between NPL3 and the nonessential genes encoding the subunits of the cap-binding complex (CBP80 and CBP20). cap 118-121 Sto1p Saccharomyces cerevisiae S288C 139-144 10823828-4 2000 In this report, we define a genetic relationship between NPL3 and the nonessential genes encoding the subunits of the cap-binding complex (CBP80 and CBP20). cap 118-121 nuclear cap-binding protein subunit CBC2 Saccharomyces cerevisiae S288C 149-154 11175261-2 2000 Disruption of this complex in enterovirus-infected cells through eIF4G cleavage is known to block this step of translation initiation, thus leading to a drastic inhibition of cap-dependent translation. cap 175-178 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 65-70 10882133-6 2000 Third, the addition of cap binding protein eIF4E inhibits deadenylation in vitro. cap 23-26 eukaryotic translation initiation factor 4E Homo sapiens 43-48 10702798-6 2000 We propose that the Apaf-1 IRES ensures that a constant cellular level of Apaf-1 protein is maintained even under conditions where cap-dependent translation is compromised. cap 131-134 apoptotic peptidase activating factor 1 Homo sapiens 20-26 10702798-6 2000 We propose that the Apaf-1 IRES ensures that a constant cellular level of Apaf-1 protein is maintained even under conditions where cap-dependent translation is compromised. cap 131-134 apoptotic peptidase activating factor 1 Homo sapiens 74-80 10394359-0 1999 Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. cap 0-3 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 88-93 10611225-0 2000 Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. cap 131-134 eukaryotic translation initiation factor 4E Homo sapiens 0-43 10611225-0 2000 Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. cap 131-134 eukaryotic translation initiation factor 4E Homo sapiens 45-50 10611225-0 2000 Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. cap 131-134 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 93-99 10611228-5 2000 Interestingly, while the overall translation rate in apoptotic cells was reduced by 60 to 70%, in accordance with the simultaneous degradation of the two major mediators of cap-dependent translation, eIF4GI and eIF4GII, the translation rate of DAP5 protein was selectively maintained. cap 173-176 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 200-206 10611228-5 2000 Interestingly, while the overall translation rate in apoptotic cells was reduced by 60 to 70%, in accordance with the simultaneous degradation of the two major mediators of cap-dependent translation, eIF4GI and eIF4GII, the translation rate of DAP5 protein was selectively maintained. cap 173-176 eukaryotic translation initiation factor 4 gamma 3 Homo sapiens 211-218 10611228-5 2000 Interestingly, while the overall translation rate in apoptotic cells was reduced by 60 to 70%, in accordance with the simultaneous degradation of the two major mediators of cap-dependent translation, eIF4GI and eIF4GII, the translation rate of DAP5 protein was selectively maintained. cap 173-176 eukaryotic translation initiation factor 4 gamma 2 Homo sapiens 244-248 10207003-4 1999 Brain-specific protein kinase C substrate, CAP-23/NAP-22, which is involved in the synaptogenesis and neuronal plasticity, binds calmodulin, but the protein lacks any canonical calmodulin-binding domain. cap 43-46 brain abundant, membrane attached signal protein 1 Rattus norvegicus 50-56 10207003-4 1999 Brain-specific protein kinase C substrate, CAP-23/NAP-22, which is involved in the synaptogenesis and neuronal plasticity, binds calmodulin, but the protein lacks any canonical calmodulin-binding domain. cap 43-46 calmodulin 1 Rattus norvegicus 129-139 10207003-4 1999 Brain-specific protein kinase C substrate, CAP-23/NAP-22, which is involved in the synaptogenesis and neuronal plasticity, binds calmodulin, but the protein lacks any canonical calmodulin-binding domain. cap 43-46 calmodulin 1 Rattus norvegicus 177-187 10207003-5 1999 In the present report, we show that CAP-23/NAP-22 isolated from rat brain is myristoylated and that the modification is directly involved in its interaction with calmodulin. cap 36-39 brain abundant, membrane attached signal protein 1 Rattus norvegicus 43-49 10207003-5 1999 In the present report, we show that CAP-23/NAP-22 isolated from rat brain is myristoylated and that the modification is directly involved in its interaction with calmodulin. cap 36-39 calmodulin 1 Rattus norvegicus 162-172 10207003-11 1999 Furthermore, phosphorylation of CAP-23/NAP-22 by protein kinase C was also found myristoylation-dependent, suggesting the importance of myristoylation in protein-protein interactions. cap 32-35 brain abundant, membrane attached signal protein 1 Rattus norvegicus 39-45 9841553-4 1998 Furo/Cap treatment significantly increased Fos-ir density above baseline levels both in structures of the lamina terminalis and hypothalamus known to mediate the actions of ANG II and in hindbrain regions associated with blood volume and pressure regulation. cap 5-8 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 43-46 10207629-4 1999 The probability of having CaP was increased in men who had nondeleted (functional) genotypes at GSTT1 (odds ratio, 1.83; 95% confidence interval, 1.19-2.80) but not GSTM1 (odds ratio, 1.07; 95% confidence interval, 0.74-1.55). cap 26-29 glutathione S-transferase theta 1 Homo sapiens 96-101 9485317-11 1998 Similarly, the eIF-4F/PABP or eIF-(iso)4F/PABP complexes show a 40-fold enhancement of cap analogue binding as compared to eIF-4F or eIF-(iso)4F alone. cap 87-90 polyadenylate-binding protein 8 Triticum aestivum 22-26 9485317-11 1998 Similarly, the eIF-4F/PABP or eIF-(iso)4F/PABP complexes show a 40-fold enhancement of cap analogue binding as compared to eIF-4F or eIF-(iso)4F alone. cap 87-90 polyadenylate-binding protein 8 Triticum aestivum 42-46 9582349-6 1998 The three-dimensional structure of 4EHP, as predicted by homology modeling, closely resembles that of eIF4E and site-directed mutagenesis analysis of 4EHP strongly suggests that it shares with eIF4E a common mechanism for cap binding. cap 222-225 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 35-39 9582349-6 1998 The three-dimensional structure of 4EHP, as predicted by homology modeling, closely resembles that of eIF4E and site-directed mutagenesis analysis of 4EHP strongly suggests that it shares with eIF4E a common mechanism for cap binding. cap 222-225 eukaryotic translation initiation factor 4E Homo sapiens 102-107 9582349-6 1998 The three-dimensional structure of 4EHP, as predicted by homology modeling, closely resembles that of eIF4E and site-directed mutagenesis analysis of 4EHP strongly suggests that it shares with eIF4E a common mechanism for cap binding. cap 222-225 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 150-154 9582349-6 1998 The three-dimensional structure of 4EHP, as predicted by homology modeling, closely resembles that of eIF4E and site-directed mutagenesis analysis of 4EHP strongly suggests that it shares with eIF4E a common mechanism for cap binding. cap 222-225 eukaryotic translation initiation factor 4E Homo sapiens 193-198 9841553-4 1998 Furo/Cap treatment significantly increased Fos-ir density above baseline levels both in structures of the lamina terminalis and hypothalamus known to mediate the actions of ANG II and in hindbrain regions associated with blood volume and pressure regulation. cap 5-8 angiotensinogen Rattus norvegicus 173-179 9841553-5 1998 Furo/Cap treatment also typically increased Fos-ir density in these structures above levels observed after administration of furosemide or captopril separately. cap 5-8 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 44-47 8971030-3 1996 This inhibition is causally related to reduced phosphorylation and consequent activation of 4E-BP1, a repressor of the function of the cap-binding protein, eIF4E. cap 135-138 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 92-98 9260870-7 1997 These results indicate that BQ is the ultimate toxic metabolite produced by tyrosinase oxidation of 4-S-CAP/4-S-CAC. cap 104-107 tyrosinase Mus musculus 76-86 9418880-9 1998 eIF4GII restores cap-dependent translation in a reticulocyte lysate which had been pretreated with rhinovirus 2A to cleave endogenous eIF4G. cap 17-20 eukaryotic translation initiation factor 4 gamma 3 Homo sapiens 0-7 9418880-9 1998 eIF4GII restores cap-dependent translation in a reticulocyte lysate which had been pretreated with rhinovirus 2A to cleave endogenous eIF4G. cap 17-20 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 0-5 9195926-2 1997 We report here that the cap-associated eukaryotic initiation factors (eIFs), i. e. the two isoforms of the cap-binding complex (eIF-4F and eIF-iso4F) and eIF-4B, bind to the poly(A)-binding protein (PABP) both in the presence and absence of poly(A) RNA. cap 24-27 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 128-134 9195926-2 1997 We report here that the cap-associated eukaryotic initiation factors (eIFs), i. e. the two isoforms of the cap-binding complex (eIF-4F and eIF-iso4F) and eIF-4B, bind to the poly(A)-binding protein (PABP) both in the presence and absence of poly(A) RNA. cap 24-27 eukaryotic translation initiation factor 4B Homo sapiens 154-160 9195926-2 1997 We report here that the cap-associated eukaryotic initiation factors (eIFs), i. e. the two isoforms of the cap-binding complex (eIF-4F and eIF-iso4F) and eIF-4B, bind to the poly(A)-binding protein (PABP) both in the presence and absence of poly(A) RNA. cap 24-27 poly(A) binding protein cytoplasmic 1 Homo sapiens 174-197 9195926-2 1997 We report here that the cap-associated eukaryotic initiation factors (eIFs), i. e. the two isoforms of the cap-binding complex (eIF-4F and eIF-iso4F) and eIF-4B, bind to the poly(A)-binding protein (PABP) both in the presence and absence of poly(A) RNA. cap 24-27 poly(A) binding protein cytoplasmic 1 Homo sapiens 199-203 9016570-2 1997 Cap-dependent initiation requires intact initiation factor eIF4G (formerly eIF-4gamma, eIF-4Fgamma or p220), whereas internal initiation can proceed with eIF4G cleaved by picornaviral 2A or L proteases. cap 0-3 eukaryotic translation initiation factor 4 gamma, 1 S homeolog Xenopus laevis 59-64 9016570-2 1997 Cap-dependent initiation requires intact initiation factor eIF4G (formerly eIF-4gamma, eIF-4Fgamma or p220), whereas internal initiation can proceed with eIF4G cleaved by picornaviral 2A or L proteases. cap 0-3 eukaryotic translation initiation factor 4 gamma, 1 S homeolog Xenopus laevis 75-85 8955119-6 1996 Cross-linking experiments identified S. pombe eIF4E as the major cap-binding protein while a further protein, p36, also showed cap-dependent binding. cap 65-68 eukaryotic translation initiation factor 4E Oryctolagus cuniculus 46-51 8971030-3 1996 This inhibition is causally related to reduced phosphorylation and consequent activation of 4E-BP1, a repressor of the function of the cap-binding protein, eIF4E. cap 135-138 eukaryotic translation initiation factor 4E Homo sapiens 156-161 8978778-0 1996 Cloning, expression, and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-GLY domain. cap 113-116 tubulin folding cofactor B Homo sapiens 36-41 8610440-9 1996 We conclude that eIF4E is dephosphorylated by entry of EMCV, and the effect is strengthened by the decrease in cap-dependent translation. cap 111-114 eukaryotic translation initiation factor 4E Homo sapiens 17-22 8534883-2 1995 In the positive-ion spectra of the peptides containing two tyrosine-O-sulfates, Cionin and CCK-associated C-terminal nonapeptide (CAP-9), the completely desulfated [M+H-2SO3]+ ions formed the base peaks, accompanying the significantly less-intense [M+H]+ and [M+H-SO3]+ ions. cap 130-133 cholecystokinin Homo sapiens 91-94 7534845-5 1995 In the cases with PSA ranging from 4.1 to 10.0 ng/ml, gamma-Sm levels in the patient with CaP were significantly lower than in those with NC (3.744 +/- 2.481 (mean +/- SD, n = 27) VS. 7.573 +/- 4.182 (n = 41), p < 0.0001) though PSA levels in both groups were not significantly different, and consequently, PSA/gamma-Sm ratio in the patients with CaP were significantly higher than in those with NC (2.181 +/- 0.802 VS. 1.095 +/- 0.804, p < 0.0001). cap 90-93 kallikrein related peptidase 3 Homo sapiens 18-21 7534845-5 1995 In the cases with PSA ranging from 4.1 to 10.0 ng/ml, gamma-Sm levels in the patient with CaP were significantly lower than in those with NC (3.744 +/- 2.481 (mean +/- SD, n = 27) VS. 7.573 +/- 4.182 (n = 41), p < 0.0001) though PSA levels in both groups were not significantly different, and consequently, PSA/gamma-Sm ratio in the patients with CaP were significantly higher than in those with NC (2.181 +/- 0.802 VS. 1.095 +/- 0.804, p < 0.0001). cap 90-93 kallikrein related peptidase 3 Homo sapiens 54-62 7665619-2 1995 Cap-dependent binding of mRNA to the 40 S ribosomal subunit during translational initiation requires the association of eukaryotic initiation factor 4G (eIF4G; formerly eIF-4 gamma and p220) with other initiation factors, notably eIF4E, eIF4A, and eIF3. cap 0-3 eukaryotic translation initiation factor 4 gamma 1 Oryctolagus cuniculus 185-189 7665619-2 1995 Cap-dependent binding of mRNA to the 40 S ribosomal subunit during translational initiation requires the association of eukaryotic initiation factor 4G (eIF4G; formerly eIF-4 gamma and p220) with other initiation factors, notably eIF4E, eIF4A, and eIF3. cap 0-3 eukaryotic translation initiation factor 4E Oryctolagus cuniculus 230-235 7665619-2 1995 Cap-dependent binding of mRNA to the 40 S ribosomal subunit during translational initiation requires the association of eukaryotic initiation factor 4G (eIF4G; formerly eIF-4 gamma and p220) with other initiation factors, notably eIF4E, eIF4A, and eIF3. cap 0-3 eukaryotic initiation factor 4A-I Oryctolagus cuniculus 237-242 7599606-6 1995 High performance liquid chromatography analysis revealed that big endothelin-1 was cleaved into several amino acid sites by CAP, but endothelin-1 was not converted from big endothelin-1. cap 124-127 endothelin 1 Homo sapiens 66-78 8063698-4 1994 Cap sites in human and rabbit BCHE genes were found in strictly homologous positions. cap 0-3 cholinesterase Oryctolagus cuniculus 30-34 8391632-8 1993 These results suggest that the association with CAP, although not involved in the in vivo response to the wild-type RAS2 protein, is somehow required for the exaggerated response of adenylyl cyclase to activated RAS2. cap 48-51 Ras family GTPase RAS2 Saccharomyces cerevisiae S288C 212-216 1536574-1 1992 Covalent modification of the active site Glu165 of triosephosphate isomerase (TPI) (EC 5.3.1.1) with the substrate analogue 3-chloroacetol phosphate (CAP) induces conformational changes similar to those observed during catalysis. cap 150-153 triosephosphate isomerase Oryctolagus cuniculus 51-76 8505316-1 1993 Eukaryotic translation initiation factor 4E (eIF-4E) is one component of the m7G-cap-binding protein complex eIF-4F and is required for cap-dependent translation initiation. cap 81-84 eukaryotic translation initiation factor 4E Homo sapiens 0-43 8505316-1 1993 Eukaryotic translation initiation factor 4E (eIF-4E) is one component of the m7G-cap-binding protein complex eIF-4F and is required for cap-dependent translation initiation. cap 81-84 eukaryotic translation initiation factor 4E Homo sapiens 45-51 8505316-1 1993 Eukaryotic translation initiation factor 4E (eIF-4E) is one component of the m7G-cap-binding protein complex eIF-4F and is required for cap-dependent translation initiation. cap 81-84 eukaryotic translation initiation factor 4E Homo sapiens 109-115 1400336-5 1992 Covalent reaction of the active site Glu165 with the substrate analogue 3-chloroacetol phosphate (CAP) results in dimers with increased susceptibility to unfolding and inactivation by denaturants (i.e. the rates of inactivation and unfolding are (TPICAP)2 greater than (TPI-TPICAP) greater than (TPI)2). cap 98-101 triosephosphate isomerase 1 Homo sapiens 247-250 1400336-5 1992 Covalent reaction of the active site Glu165 with the substrate analogue 3-chloroacetol phosphate (CAP) results in dimers with increased susceptibility to unfolding and inactivation by denaturants (i.e. the rates of inactivation and unfolding are (TPICAP)2 greater than (TPI-TPICAP) greater than (TPI)2). cap 98-101 triosephosphate isomerase 1 Homo sapiens 270-273 1439067-16 1992 CAP + HCTZ controlled (DBP < 90 mHg) 85% and CAP + NIF 81.25% of patients. cap 0-3 D-box binding PAR bZIP transcription factor Homo sapiens 23-26 1536574-1 1992 Covalent modification of the active site Glu165 of triosephosphate isomerase (TPI) (EC 5.3.1.1) with the substrate analogue 3-chloroacetol phosphate (CAP) induces conformational changes similar to those observed during catalysis. cap 150-153 triosephosphate isomerase Oryctolagus cuniculus 78-81 1536574-3 1992 CAP binding accelerated the specific deamidation of Asn71 in mammalian TPI. cap 0-3 triosephosphate isomerase 1 Homo sapiens 71-74 34943253-8 2021 Exposure to low doses of CAP enhanced the proliferation rate of cells and stimulated the expression of key genes (KGF, MMP2, GMCSF, IL-6, and IL-8) in fibroblasts, indicating the activation and initiation of the skin repair process. cap 25-28 fibroblast growth factor 7 Homo sapiens 114-117 1672854-3 1991 Cap binding abilities of two mutants, W102L (Trp-102----Leu) and E105A (Glu-105----Ala), were significantly decreased in comparison with the wild-type hCBP. cap 0-3 CREB binding protein Homo sapiens 151-155 2386781-11 1990 Tryptic and CNBr cleavage suggested that eIF-4E* consists of a protease-resistant core of eIF-4E that retains the cap-binding site and consists of approximately residues 47-182. cap 114-117 eukaryotic translation initiation factor 4E Homo sapiens 41-47 2386781-11 1990 Tryptic and CNBr cleavage suggested that eIF-4E* consists of a protease-resistant core of eIF-4E that retains the cap-binding site and consists of approximately residues 47-182. cap 114-117 eukaryotic translation initiation factor 4E Homo sapiens 90-96 2065677-10 1991 Bound PGA exhibited a pH-independent 31P-NMR resonance which was readily distinguishable from resonances of CAP-TPI and free PGA. cap 108-111 triosephosphate isomerase Oryctolagus cuniculus 112-115 34943253-8 2021 Exposure to low doses of CAP enhanced the proliferation rate of cells and stimulated the expression of key genes (KGF, MMP2, GMCSF, IL-6, and IL-8) in fibroblasts, indicating the activation and initiation of the skin repair process. cap 25-28 matrix metallopeptidase 2 Homo sapiens 119-123 34943253-8 2021 Exposure to low doses of CAP enhanced the proliferation rate of cells and stimulated the expression of key genes (KGF, MMP2, GMCSF, IL-6, and IL-8) in fibroblasts, indicating the activation and initiation of the skin repair process. cap 25-28 colony stimulating factor 2 Homo sapiens 125-130 34943253-8 2021 Exposure to low doses of CAP enhanced the proliferation rate of cells and stimulated the expression of key genes (KGF, MMP2, GMCSF, IL-6, and IL-8) in fibroblasts, indicating the activation and initiation of the skin repair process. cap 25-28 interleukin 6 Homo sapiens 132-136 34943253-8 2021 Exposure to low doses of CAP enhanced the proliferation rate of cells and stimulated the expression of key genes (KGF, MMP2, GMCSF, IL-6, and IL-8) in fibroblasts, indicating the activation and initiation of the skin repair process. cap 25-28 C-X-C motif chemokine ligand 8 Homo sapiens 142-146 34479596-7 2021 Finally, the effects of CAP on caspase-3 activity were examined using a caspase-3 assay. cap 24-27 caspase 3 Homo sapiens 31-40 34740724-2 2021 Herein, a serum-stable polymer-calcium phosphate (CaP) hybrid nanocapsule carrying siRNA against ADP-ribosylation factor 6 (Arf6) overexpressed in cancer cells and parent drug camptothecin (CPT), designated as PTkCPT/siRNA, was developed for the RNAi-induced oxidative catastrophe and cascaded chemotherapy. cap 50-53 ADP-ribosylation factor 6 Mus musculus 97-122 34740724-2 2021 Herein, a serum-stable polymer-calcium phosphate (CaP) hybrid nanocapsule carrying siRNA against ADP-ribosylation factor 6 (Arf6) overexpressed in cancer cells and parent drug camptothecin (CPT), designated as PTkCPT/siRNA, was developed for the RNAi-induced oxidative catastrophe and cascaded chemotherapy. cap 50-53 ADP-ribosylation factor 6 Mus musculus 124-128 34829774-7 2021 In this model, CAP-treated mice showed significantly reduced dermal thickness and collagen deposition as well as a decrease in both alpha smooth muscle actin-positive myofibroblasts and CD68-positive macrophages in the affected skin in comparison to untreated fibrotic tissue. cap 15-18 CD68 antigen Mus musculus 186-190 34825002-4 2021 Here, we investigated the combined effects of CAP and CUR on cytotoxicity and apoptosis in B16-F10 melanoma cancer cells compared to L929 normal cells using MTT method, acridine orange/ethidium bromide fluorescence microscopic assay, and Annexin V/PI flow cytometry. cap 46-49 annexin A5 Mus musculus 238-247 34479596-8 2021 RESULTS: CAP treatment resulted in a significant downregulation of p53 and apoptotic protease activating factor (APAF)-1, caspase (CASP)9, CASP3, BCL2 Antagonist/Killer (BAK)1, and B-Cell Lymphoma (BCL)2 mRNA expression at 1 d. An inhibitory effect of CAP on apoptotic genes was also shown under inflammatory and apoptotic conditions. cap 9-12 tumor protein p53 Homo sapiens 67-70 34479596-8 2021 RESULTS: CAP treatment resulted in a significant downregulation of p53 and apoptotic protease activating factor (APAF)-1, caspase (CASP)9, CASP3, BCL2 Antagonist/Killer (BAK)1, and B-Cell Lymphoma (BCL)2 mRNA expression at 1 d. An inhibitory effect of CAP on apoptotic genes was also shown under inflammatory and apoptotic conditions. cap 9-12 apoptotic peptidase activating factor 1 Homo sapiens 75-120 34479596-8 2021 RESULTS: CAP treatment resulted in a significant downregulation of p53 and apoptotic protease activating factor (APAF)-1, caspase (CASP)9, CASP3, BCL2 Antagonist/Killer (BAK)1, and B-Cell Lymphoma (BCL)2 mRNA expression at 1 d. An inhibitory effect of CAP on apoptotic genes was also shown under inflammatory and apoptotic conditions. cap 9-12 caspase 9 Homo sapiens 122-129 34479596-8 2021 RESULTS: CAP treatment resulted in a significant downregulation of p53 and apoptotic protease activating factor (APAF)-1, caspase (CASP)9, CASP3, BCL2 Antagonist/Killer (BAK)1, and B-Cell Lymphoma (BCL)2 mRNA expression at 1 d. An inhibitory effect of CAP on apoptotic genes was also shown under inflammatory and apoptotic conditions. cap 9-12 caspase 9 Homo sapiens 131-137 34479596-8 2021 RESULTS: CAP treatment resulted in a significant downregulation of p53 and apoptotic protease activating factor (APAF)-1, caspase (CASP)9, CASP3, BCL2 Antagonist/Killer (BAK)1, and B-Cell Lymphoma (BCL)2 mRNA expression at 1 d. An inhibitory effect of CAP on apoptotic genes was also shown under inflammatory and apoptotic conditions. cap 9-12 caspase 3 Homo sapiens 139-144 34479596-8 2021 RESULTS: CAP treatment resulted in a significant downregulation of p53 and apoptotic protease activating factor (APAF)-1, caspase (CASP)9, CASP3, BCL2 Antagonist/Killer (BAK)1, and B-Cell Lymphoma (BCL)2 mRNA expression at 1 d. An inhibitory effect of CAP on apoptotic genes was also shown under inflammatory and apoptotic conditions. cap 9-12 BCL2 antagonist/killer 1 Homo sapiens 146-175 34479596-8 2021 RESULTS: CAP treatment resulted in a significant downregulation of p53 and apoptotic protease activating factor (APAF)-1, caspase (CASP)9, CASP3, BCL2 Antagonist/Killer (BAK)1, and B-Cell Lymphoma (BCL)2 mRNA expression at 1 d. An inhibitory effect of CAP on apoptotic genes was also shown under inflammatory and apoptotic conditions. cap 9-12 BCL2 apoptosis regulator Homo sapiens 181-203 34327871-5 2021 Exposure to CAP significantly increased the urinary excretion of acrolein metabolite (3HPMA) as well as the abundance of protein-acrolein adducts (a marker of oxidative stress) in PVAT and aorta, upregulated PVAT leptin mRNA expression without changing mRNA levels of several proinflammatory genes, and induced PVAT insulin resistance. cap 12-15 leptin Mus musculus 213-219 34067898-12 2021 Moreover, CAP treatment resulted in an upregulation of KI67, higher cell viability, and improved cell migration. cap 10-13 antigen identified by monoclonal antibody Ki 67 Mus musculus 55-59 35181947-10 2022 Interestingly, there was an overall greater increase of Lc3 and Atg5 in the tumor tissue compared to CAP exposure alone, while starvation-induced autophagy-related gene expression was similar to in the combination group. cap 101-104 microtubule-associated protein 1 light chain 3 alpha Mus musculus 56-59 34459761-7 2021 CONCLUSION: Conclusions: Pioglitazone and PPARG rs1801282 polymorphism could influence on dynamics of CAP reduction during treatment. cap 102-105 peroxisome proliferator activated receptor gamma Homo sapiens 42-47 35181947-10 2022 Interestingly, there was an overall greater increase of Lc3 and Atg5 in the tumor tissue compared to CAP exposure alone, while starvation-induced autophagy-related gene expression was similar to in the combination group. cap 101-104 autophagy related 5 Mus musculus 64-68 35111687-5 2021 CAP treatment induced intense phenotypic changes and apoptosis in both ER+ and ER- cells, which is associated with the mitochondrial pathway as evidenced by the increased Bax/Bcl-2 ratio and cleavage of PARP-1. cap 0-3 estrogen receptor 1 Homo sapiens 71-73 35111687-5 2021 CAP treatment induced intense phenotypic changes and apoptosis in both ER+ and ER- cells, which is associated with the mitochondrial pathway as evidenced by the increased Bax/Bcl-2 ratio and cleavage of PARP-1. cap 0-3 estrogen receptor 1 Homo sapiens 79-81 35111687-5 2021 CAP treatment induced intense phenotypic changes and apoptosis in both ER+ and ER- cells, which is associated with the mitochondrial pathway as evidenced by the increased Bax/Bcl-2 ratio and cleavage of PARP-1. cap 0-3 BCL2 associated X, apoptosis regulator Homo sapiens 171-174 35111687-5 2021 CAP treatment induced intense phenotypic changes and apoptosis in both ER+ and ER- cells, which is associated with the mitochondrial pathway as evidenced by the increased Bax/Bcl-2 ratio and cleavage of PARP-1. cap 0-3 BCL2 apoptosis regulator Homo sapiens 175-180 35111687-5 2021 CAP treatment induced intense phenotypic changes and apoptosis in both ER+ and ER- cells, which is associated with the mitochondrial pathway as evidenced by the increased Bax/Bcl-2 ratio and cleavage of PARP-1. cap 0-3 poly(ADP-ribose) polymerase 1 Homo sapiens 203-209 3701067-8 1986 The amino acid required for binding of Cap-4, Cap-5, and Rh-4 could arise by a single base change in the beta globin gene, whereas the amino acid required for Rh-2 binding would only occur if two base changes occurred. cap 39-42 Rh associated glycoprotein Homo sapiens 159-163 35242647-3 2022 The clinical data of 256 children with grade I-V VUR receiving CAP were analysed. cap 63-66 VUR Homo sapiens 49-52 35242647-6 2022 Results: BT-UTI occurred in 81 out of 256 children with grade I-V VUR who received CAP, an incidence of 31.64%. cap 83-86 VUR Homo sapiens 66-69 2607648-3 1989 At first, more specific and adequate inhibitor for other serum peptidases, such as membrane-bound aminopeptidase (EC 3.4.11.2; arylamidase, AA) and cystyl aminopeptidase (EC 3.4.11.3; CAP) was selected from 1,10-phenanthroline derivatives. cap 184-187 carboxypeptidase Q Homo sapiens 98-112 34029575-5 2021 In addition, CAP treatment reduced the infiltration of CD11c+ dendritic cells, CD3+ T cells, and CD8+ T cells; inhibited the release of chemokine (C-X-C motif) ligand 10 and cytokine interferon-gamma; and enhanced cellular resistance to oxidative stress and excessive immune response by enhancing the expression of the transcription factor Nrf2 and attenuating the activity of inducible nitric oxide synthase. cap 13-16 integrin subunit alpha X Homo sapiens 55-60 6864283-3 1983 The relationship between CAP and SP was expressed by the best-fit equation CAP = 1.02 SP -9.27 in the normotensive patients and by CAP = 1.54 SP -65.60 in the hypertensive patients. cap 25-28 cyclase associated actin cytoskeleton regulatory protein 1 Homo sapiens 75-82 6864283-3 1983 The relationship between CAP and SP was expressed by the best-fit equation CAP = 1.02 SP -9.27 in the normotensive patients and by CAP = 1.54 SP -65.60 in the hypertensive patients. cap 25-28 cyclase associated actin cytoskeleton regulatory protein 1 Homo sapiens 131-138 34029575-5 2021 In addition, CAP treatment reduced the infiltration of CD11c+ dendritic cells, CD3+ T cells, and CD8+ T cells; inhibited the release of chemokine (C-X-C motif) ligand 10 and cytokine interferon-gamma; and enhanced cellular resistance to oxidative stress and excessive immune response by enhancing the expression of the transcription factor Nrf2 and attenuating the activity of inducible nitric oxide synthase. cap 13-16 NFE2 like bZIP transcription factor 2 Homo sapiens 340-344 34029575-5 2021 In addition, CAP treatment reduced the infiltration of CD11c+ dendritic cells, CD3+ T cells, and CD8+ T cells; inhibited the release of chemokine (C-X-C motif) ligand 10 and cytokine interferon-gamma; and enhanced cellular resistance to oxidative stress and excessive immune response by enhancing the expression of the transcription factor Nrf2 and attenuating the activity of inducible nitric oxide synthase. cap 13-16 CD8a molecule Homo sapiens 97-100 34029575-5 2021 In addition, CAP treatment reduced the infiltration of CD11c+ dendritic cells, CD3+ T cells, and CD8+ T cells; inhibited the release of chemokine (C-X-C motif) ligand 10 and cytokine interferon-gamma; and enhanced cellular resistance to oxidative stress and excessive immune response by enhancing the expression of the transcription factor Nrf2 and attenuating the activity of inducible nitric oxide synthase. cap 13-16 C-X-C motif chemokine ligand 10 Homo sapiens 136-169 34029575-5 2021 In addition, CAP treatment reduced the infiltration of CD11c+ dendritic cells, CD3+ T cells, and CD8+ T cells; inhibited the release of chemokine (C-X-C motif) ligand 10 and cytokine interferon-gamma; and enhanced cellular resistance to oxidative stress and excessive immune response by enhancing the expression of the transcription factor Nrf2 and attenuating the activity of inducible nitric oxide synthase. cap 13-16 interferon gamma Homo sapiens 183-199 33712123-8 2021 Under the synergistic effect of HA and CAP treatment, scaffolds achieved 277.6 % cell viability compared with pure CS scaffold. cap 39-42 citrate synthase Homo sapiens 115-117 32880467-9 2021 In addition, the transcript and protein levels of c-FOS were robustly increased after co-treated with metformin and CAP. cap 116-119 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 50-55 32993057-15 2020 The caspase 3/7 assay and TUNEL assay showed a significant increase in apoptotic processes in the HDMEC after CAP treatment. cap 110-113 caspase 3 Homo sapiens 4-13 33096638-3 2020 Here, the key concept is a reactivation of two specific apoptotic cell signaling pathways through catalase inactivation caused by CAP. cap 130-133 catalase Homo sapiens 98-106 33096638-6 2020 In the present study, we develop a mathematical model to analyze the proposed catalase-dependent anti-cancer effect of CAP. cap 119-122 catalase Homo sapiens 78-86 32178401-9 2020 CONCLUSION: CAP and SN together activate autophagy in G-361 cells by activating PI3K/mTOR and EGFR pathways, expressing autophagy-related transcription factors and genes. cap 12-15 mechanistic target of rapamycin kinase Homo sapiens 85-89 32062076-6 2020 Besides, Cap attenuated APAP-induced overproduction and release of proinflammatory mediators like TNF-alpha, IL-1beta, IL-17A, IL-6, and MCP-1. cap 9-12 tumor necrosis factor Homo sapiens 98-107 32062076-6 2020 Besides, Cap attenuated APAP-induced overproduction and release of proinflammatory mediators like TNF-alpha, IL-1beta, IL-17A, IL-6, and MCP-1. cap 9-12 interleukin 1 alpha Homo sapiens 109-117 32062076-6 2020 Besides, Cap attenuated APAP-induced overproduction and release of proinflammatory mediators like TNF-alpha, IL-1beta, IL-17A, IL-6, and MCP-1. cap 9-12 interleukin 6 Homo sapiens 127-131 32062076-6 2020 Besides, Cap attenuated APAP-induced overproduction and release of proinflammatory mediators like TNF-alpha, IL-1beta, IL-17A, IL-6, and MCP-1. cap 9-12 C-C motif chemokine ligand 2 Homo sapiens 137-142 32062076-7 2020 Cap treatment also led to avoidance of APAP-subsequent repair by abating APAP-induced elevation of hepatic IL-22 and PCNA expressions. cap 0-3 interleukin 22 Homo sapiens 107-112 32062076-7 2020 Cap treatment also led to avoidance of APAP-subsequent repair by abating APAP-induced elevation of hepatic IL-22 and PCNA expressions. cap 0-3 proliferating cell nuclear antigen Homo sapiens 117-121 32178401-9 2020 CONCLUSION: CAP and SN together activate autophagy in G-361 cells by activating PI3K/mTOR and EGFR pathways, expressing autophagy-related transcription factors and genes. cap 12-15 epidermal growth factor receptor Homo sapiens 94-98 29871559-3 2019 The eukaryotic translation initiation factor 3 subunit e (eIF3e) protein is a component of the multisubunit eIF3 complex essential for cap-dependent translation initiation. cap 135-138 eukaryotic translation initiation factor 3 subunit E Homo sapiens 4-56 32079108-5 2020 Our results showed that CAP and AuQDs induced dual cytotoxicity in brain cancer cells via Fas/TRAIL-mediated cell death receptor pathways. cap 24-27 TNF superfamily member 10 Homo sapiens 94-99 30420719-6 2019 Suppression of cap-dependent translation by 4EGI-1 resulted in diminished expression of oncogenic proteins c-Myc, Bcl-2, cyclin D1, and survivin, whereas beta-actin expression was left unchanged. cap 15-18 MYC proto-oncogene, bHLH transcription factor Homo sapiens 107-112 30420719-6 2019 Suppression of cap-dependent translation by 4EGI-1 resulted in diminished expression of oncogenic proteins c-Myc, Bcl-2, cyclin D1, and survivin, whereas beta-actin expression was left unchanged. cap 15-18 BCL2 apoptosis regulator Homo sapiens 114-119 30420719-6 2019 Suppression of cap-dependent translation by 4EGI-1 resulted in diminished expression of oncogenic proteins c-Myc, Bcl-2, cyclin D1, and survivin, whereas beta-actin expression was left unchanged. cap 15-18 cyclin D1 Homo sapiens 121-130 31894670-12 2019 HPE and Cap could improve or decrease the MF level and CVF of the MFEAM model mice, and down-regulated the expression of TGF-beta1 protein in different degrees. cap 8-11 transforming growth factor, beta 1 Mus musculus 121-130 31118010-9 2019 CONCLUSIONS: We show that 4EBP1 is a critical regulator of the mitogen responsive RAS/ERK and PI3K/AKT pathways and a key transducer of resistance mechanisms that affect small molecule inhibition of these pathways, principally by attenuating their effects on cap-dependent translation. cap 259-262 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 26-31 31118010-9 2019 CONCLUSIONS: We show that 4EBP1 is a critical regulator of the mitogen responsive RAS/ERK and PI3K/AKT pathways and a key transducer of resistance mechanisms that affect small molecule inhibition of these pathways, principally by attenuating their effects on cap-dependent translation. cap 259-262 mitogen-activated protein kinase 1 Homo sapiens 86-89 31223425-7 2019 Thus, the induction of Nrf2-mediated oxidative and endoplasmic reticulum stress response, PPAR-alpha/RXR activation as well as production of peroxisomes, and prevention of apoptosis already during the first hour after CAP treatment are important cell strategies to overcome oxidative stress and to protect and maintain cell integrity and especially microtubule dynamics. cap 218-221 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 31114251-10 2019 Finally, it was demonstrated that increased AKT and serum and glucocorticoid-inducible kinase 1 activity contributed to the activation of cap-dependent translation induced by INPP4B. cap 138-141 AKT serine/threonine kinase 1 Homo sapiens 44-47 31114251-10 2019 Finally, it was demonstrated that increased AKT and serum and glucocorticoid-inducible kinase 1 activity contributed to the activation of cap-dependent translation induced by INPP4B. cap 138-141 inositol polyphosphate-4-phosphatase type II B Homo sapiens 175-181 29871559-3 2019 The eukaryotic translation initiation factor 3 subunit e (eIF3e) protein is a component of the multisubunit eIF3 complex essential for cap-dependent translation initiation. cap 135-138 eukaryotic translation initiation factor 3 subunit E Homo sapiens 58-63 29871559-3 2019 The eukaryotic translation initiation factor 3 subunit e (eIF3e) protein is a component of the multisubunit eIF3 complex essential for cap-dependent translation initiation. cap 135-138 eukaryotic translation initiation factor 3 subunit A Homo sapiens 58-62 30691003-6 2019 In this study, we showed that the DLL4 5"-UTR harbors an Internal Ribosomal Entry Site (IRES) that, in contrast to cap-dependent translation, was efficiently utilized in cells subjected to several stresses including hypoxia and endoplasmic reticulum stress (ER stress). cap 115-118 delta like canonical Notch ligand 4 Homo sapiens 34-38 30514892-8 2018 Osteogenic differentiation results indicated that conjugating of biomimetic ASP templated peptides sharply increased alkaline phosphatase (ALP) activity, calcium content, and expression of key osteogenic markers of collagen type I (Col-I), osteocalcin (OC), and osteopontin (OP) compared to GLU conjugated (GLU-pNF) and CAP treated NF (pNF). cap 320-323 assembly factor for spindle microtubules Homo sapiens 76-79 30455356-3 2019 CLIP-170 contains two N-terminal cytoskeleton-associated protein glycine-rich (CAP-Gly) domains flanked by serine-rich regions. cap 79-82 CAP-Gly domain containing linker protein 1 Homo sapiens 0-8 30403859-3 2018 Here, a chlorantraniliprole-glycine conjugate (CAP-Gly-1) was tested for its affinity to AtLHT1 both in planta and in vitro. cap 47-50 lysine histidine transporter 1 Arabidopsis thaliana 89-95 30403859-4 2018 Seedlings deficient in AtLHT1 exhibited a reduction with respect to both the uptake and root-to-shoot transfer of CAP-Gly-1; plants in which AtLHT1 was constitutively expressed were more effective than wild type in term of their root uptake of CAP-Gly-1. cap 114-117 lysine histidine transporter 1 Arabidopsis thaliana 23-29 30403859-4 2018 Seedlings deficient in AtLHT1 exhibited a reduction with respect to both the uptake and root-to-shoot transfer of CAP-Gly-1; plants in which AtLHT1 was constitutively expressed were more effective than wild type in term of their root uptake of CAP-Gly-1. cap 244-247 lysine histidine transporter 1 Arabidopsis thaliana 23-29 30403859-4 2018 Seedlings deficient in AtLHT1 exhibited a reduction with respect to both the uptake and root-to-shoot transfer of CAP-Gly-1; plants in which AtLHT1 was constitutively expressed were more effective than wild type in term of their root uptake of CAP-Gly-1. cap 244-247 lysine histidine transporter 1 Arabidopsis thaliana 141-147 30403859-5 2018 Protoplast patch clamping showed that the presence in the external medium of CAP-Gly-1 was able to induce AtLHT1 genotype-dependent inward currents. cap 77-80 lysine histidine transporter 1 Arabidopsis thaliana 106-112 30403859-6 2018 An electrophysiology-based experiment carried out in Xenopus laevis oocytes expressing AtLHT1 showed that AtLHT1 had a high in vitro affinity for CAP-Gly-1. cap 146-149 lysine histidine transporter 1 Arabidopsis thaliana 87-93 30403859-6 2018 An electrophysiology-based experiment carried out in Xenopus laevis oocytes expressing AtLHT1 showed that AtLHT1 had a high in vitro affinity for CAP-Gly-1. cap 146-149 lysine histidine transporter 1 Arabidopsis thaliana 106-112 30400326-4 2018 Exposing monocytes to CaP-CHI-HA resulted in a secretion of pro-healing VEGF and TGF-beta growth factors, TNF-alpha, MCP-1, IL-6 and IL-8 pro-inflammatory mediators but also IL-10 anti-inflammatory cytokine along with an inflammatory index below 1.5 (versus 2.5 and 7.5 following CaP and LPS stimulation, respectively). cap 22-25 C-C motif chemokine ligand 2 Homo sapiens 117-122 30400326-4 2018 Exposing monocytes to CaP-CHI-HA resulted in a secretion of pro-healing VEGF and TGF-beta growth factors, TNF-alpha, MCP-1, IL-6 and IL-8 pro-inflammatory mediators but also IL-10 anti-inflammatory cytokine along with an inflammatory index below 1.5 (versus 2.5 and 7.5 following CaP and LPS stimulation, respectively). cap 22-25 interleukin 6 Homo sapiens 124-128 30400326-4 2018 Exposing monocytes to CaP-CHI-HA resulted in a secretion of pro-healing VEGF and TGF-beta growth factors, TNF-alpha, MCP-1, IL-6 and IL-8 pro-inflammatory mediators but also IL-10 anti-inflammatory cytokine along with an inflammatory index below 1.5 (versus 2.5 and 7.5 following CaP and LPS stimulation, respectively). cap 22-25 vascular endothelial growth factor A Homo sapiens 72-76 30400326-4 2018 Exposing monocytes to CaP-CHI-HA resulted in a secretion of pro-healing VEGF and TGF-beta growth factors, TNF-alpha, MCP-1, IL-6 and IL-8 pro-inflammatory mediators but also IL-10 anti-inflammatory cytokine along with an inflammatory index below 1.5 (versus 2.5 and 7.5 following CaP and LPS stimulation, respectively). cap 22-25 tumor necrosis factor Homo sapiens 106-115 30400326-4 2018 Exposing monocytes to CaP-CHI-HA resulted in a secretion of pro-healing VEGF and TGF-beta growth factors, TNF-alpha, MCP-1, IL-6 and IL-8 pro-inflammatory mediators but also IL-10 anti-inflammatory cytokine along with an inflammatory index below 1.5 (versus 2.5 and 7.5 following CaP and LPS stimulation, respectively). cap 22-25 C-X-C motif chemokine ligand 8 Homo sapiens 133-137 30400326-4 2018 Exposing monocytes to CaP-CHI-HA resulted in a secretion of pro-healing VEGF and TGF-beta growth factors, TNF-alpha, MCP-1, IL-6 and IL-8 pro-inflammatory mediators but also IL-10 anti-inflammatory cytokine along with an inflammatory index below 1.5 (versus 2.5 and 7.5 following CaP and LPS stimulation, respectively). cap 22-25 interleukin 10 Homo sapiens 174-179 30070768-4 2018 The high endogenous ROS content in cancer cells triggers rapid removal of the 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl carbonyl (OBP) cap to release active SAHA. cap 147-150 odorant binding protein 2A Homo sapiens 142-145 30084355-4 2018 Cells lacking Scs2/Scs22 performed spindle positioning via MT end capture-shrinkage mechanism, requiring dynein anchorage to an ER- and mitochondria-independent population of Num1, dynein motor activity, and CAP-Gly domain of dynactin Nip100/p150Glued subunit. cap 208-211 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 14-18 29761560-5 2018 4E-BP1 is an inhibitor of cap-dependent translation those functions are inhibited by mTORC1 mediated phosphorylation. cap 26-29 CREB regulated transcription coactivator 1 Mus musculus 85-91 29761560-5 2018 4E-BP1 is an inhibitor of cap-dependent translation those functions are inhibited by mTORC1 mediated phosphorylation. cap 26-29 eukaryotic translation initiation factor 4E binding protein 1 Rattus norvegicus 0-6 30012863-0 2018 Ribosomal RACK1:Protein Kinase C betaII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation. cap 109-112 receptor for activated C kinase 1 Homo sapiens 10-15 30012863-0 2018 Ribosomal RACK1:Protein Kinase C betaII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation. cap 109-112 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 55-87 30084355-4 2018 Cells lacking Scs2/Scs22 performed spindle positioning via MT end capture-shrinkage mechanism, requiring dynein anchorage to an ER- and mitochondria-independent population of Num1, dynein motor activity, and CAP-Gly domain of dynactin Nip100/p150Glued subunit. cap 208-211 phospholipid metabolism-regulating protein SCS22 Saccharomyces cerevisiae S288C 19-24 29901187-2 2018 In the current study, comprehensive bioinformatic analyses were performed to develop a novel scoring system for GC risk assessment based on CAP-Gly domain containing linker protein family member 4 (CLIP4) DNA methylation status. cap 140-143 CAP-Gly domain containing linker protein family member 4 Homo sapiens 198-203 29576319-3 2018 The crystal structures of the CAP-Gly domain of Bik1 (Bik1CG) alone and in complex with an ETF peptide revealed unique, functionally relevant CAP-Gly elements, establishing Bik1CG as a specific C-terminal phenylalanine recognition domain. cap 30-33 Bik1p Saccharomyces cerevisiae S288C 48-52 29576319-3 2018 The crystal structures of the CAP-Gly domain of Bik1 (Bik1CG) alone and in complex with an ETF peptide revealed unique, functionally relevant CAP-Gly elements, establishing Bik1CG as a specific C-terminal phenylalanine recognition domain. cap 30-33 TEA domain transcription factor 2 Homo sapiens 91-94 28322282-9 2018 The cap-dependent translation initiation gene, EIF4E, is one of the most MIA-dysregulated of all ASD-associated genes and targeted network analyses demonstrate prominent MIA-induced transcriptional dysregulation of mTOR and EIF4E-dependent signaling. cap 4-7 eukaryotic translation initiation factor 4E Homo sapiens 47-52 28322282-9 2018 The cap-dependent translation initiation gene, EIF4E, is one of the most MIA-dysregulated of all ASD-associated genes and targeted network analyses demonstrate prominent MIA-induced transcriptional dysregulation of mTOR and EIF4E-dependent signaling. cap 4-7 mechanistic target of rapamycin kinase Homo sapiens 215-219 28322282-9 2018 The cap-dependent translation initiation gene, EIF4E, is one of the most MIA-dysregulated of all ASD-associated genes and targeted network analyses demonstrate prominent MIA-induced transcriptional dysregulation of mTOR and EIF4E-dependent signaling. cap 4-7 eukaryotic translation initiation factor 4E Homo sapiens 224-229 29410383-6 2018 RESULTS: CAP exposure was associated with significantly higher tumor necrosis factor-alpha (TNFalpha) and interleukin (IL)-6 mRNA in the hypothalamus of control mice, but not IKK2Neu-KO mice. cap 9-12 tumor necrosis factor Mus musculus 63-90 29410383-6 2018 RESULTS: CAP exposure was associated with significantly higher tumor necrosis factor-alpha (TNFalpha) and interleukin (IL)-6 mRNA in the hypothalamus of control mice, but not IKK2Neu-KO mice. cap 9-12 tumor necrosis factor Mus musculus 92-100 29410383-6 2018 RESULTS: CAP exposure was associated with significantly higher tumor necrosis factor-alpha (TNFalpha) and interleukin (IL)-6 mRNA in the hypothalamus of control mice, but not IKK2Neu-KO mice. cap 9-12 interleukin 6 Mus musculus 106-124 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 epidermal growth factor Homo sapiens 79-82 30205404-0 2018 Chinese Angelica Polysaccharide (CAP) Alleviates LPS-Induced Inflammation and Apoptosis by Down-Regulating COX-1 in PC12 Cells. cap 33-36 cytochrome c oxidase I, mitochondrial Rattus norvegicus 107-112 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 prokineticin 1 Homo sapiens 84-91 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 prokineticin 1 Homo sapiens 93-96 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 endothelin 1 Homo sapiens 99-111 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 fibroblast growth factor 2 Homo sapiens 120-125 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 C-X-C motif chemokine ligand 8 Homo sapiens 139-143 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 C-X-C motif chemokine ligand 8 Homo sapiens 145-150 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 proline rich acidic protein 1 Homo sapiens 156-159 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 angiogenin Homo sapiens 181-191 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 angiogenin Homo sapiens 193-196 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 collagen type XVIII alpha 1 chain Homo sapiens 199-209 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 collagen type XVIII alpha 1 chain Homo sapiens 211-218 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 C-C motif chemokine ligand 2 Homo sapiens 221-226 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 C-C motif chemokine ligand 2 Homo sapiens 228-232 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 matrix metallopeptidase 9 Homo sapiens 235-240 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 TIMP metallopeptidase inhibitor 1 Homo sapiens 242-248 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 proline rich acidic protein 1 Homo sapiens 250-253 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 vascular endothelial growth factor A Homo sapiens 87-91 28064055-4 2017 In hepatic injury model mice, sCAP could significantly reduce ALT, AST and ALP contents and raised TP content in serum, significantly reduce MDA and ROS contents and raised SOD and T-AOC activities in liver homogenate in comparison with CAP; obviously relieve the pathological changes of liver and significantly inhibit the expressions of p-ERK, p-JNK and p-p38 protein as compared with those in model control group. cap 31-34 glutamic pyruvic transaminase, soluble Mus musculus 62-65 28940421-10 2018 CONCLUSIONS: Changes in PASP strongly correlated with radiological severity of CAP and PaO2 . cap 79-82 carboxypeptidase B1 Homo sapiens 24-28 28917655-8 2017 Consistent with glucose homeostasis assessments, CAP exposure significantly increased the body weight and adiposity of TNF/LT KO but not WT mice. cap 49-52 tumor necrosis factor Mus musculus 119-128 28917655-10 2017 On the other hand, CAP exposure induced marked fat droplet accumulation in brown adipose tissues of WT mice and significantly decreased their uncoupling protein 1 (UCP1) expression, and these effects were markedly exacerbated in TNF/LT KO mice. cap 19-22 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 142-162 28917655-10 2017 On the other hand, CAP exposure induced marked fat droplet accumulation in brown adipose tissues of WT mice and significantly decreased their uncoupling protein 1 (UCP1) expression, and these effects were markedly exacerbated in TNF/LT KO mice. cap 19-22 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 164-168 28917655-10 2017 On the other hand, CAP exposure induced marked fat droplet accumulation in brown adipose tissues of WT mice and significantly decreased their uncoupling protein 1 (UCP1) expression, and these effects were markedly exacerbated in TNF/LT KO mice. cap 19-22 tumor necrosis factor Mus musculus 229-232 28645299-10 2017 Pyrosequencing demonstrated that the leptin promoter methylation of adipocytes was significantly increased in CAP-exposed male but not female offspring. cap 110-113 leptin Mus musculus 37-43 28539821-1 2017 Objectives: 4E-BP1 is a family member of eIF4E binding proteins (4E-BPs) which act as the suppressors of cap-dependent translation of RNA via competitively associating with cap-bound eIF4E. cap 105-108 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 12-18 28539821-1 2017 Objectives: 4E-BP1 is a family member of eIF4E binding proteins (4E-BPs) which act as the suppressors of cap-dependent translation of RNA via competitively associating with cap-bound eIF4E. cap 105-108 eukaryotic translation initiation factor 4E Homo sapiens 41-46 28539821-1 2017 Objectives: 4E-BP1 is a family member of eIF4E binding proteins (4E-BPs) which act as the suppressors of cap-dependent translation of RNA via competitively associating with cap-bound eIF4E. cap 105-108 eukaryotic translation initiation factor 4E Homo sapiens 183-188 28438065-3 2018 The eukaryotic translation initiation factor 3 subunit e (eIF3e) protein is a component of the multisubunit eIF3 complex essential for cap-dependent translation initiation. cap 135-138 eukaryotic translation initiation factor 3 subunit E Homo sapiens 4-56 28438065-3 2018 The eukaryotic translation initiation factor 3 subunit e (eIF3e) protein is a component of the multisubunit eIF3 complex essential for cap-dependent translation initiation. cap 135-138 eukaryotic translation initiation factor 3 subunit E Homo sapiens 58-63 28438065-3 2018 The eukaryotic translation initiation factor 3 subunit e (eIF3e) protein is a component of the multisubunit eIF3 complex essential for cap-dependent translation initiation. cap 135-138 eukaryotic translation initiation factor 3 subunit A Homo sapiens 58-62 29166596-2 2017 Here, we use a Drosophila model to demonstrate that antimicrobial peptide (AMP) production during infection is paradoxically stimulated by the inhibitor of cap-dependent translation, 4E-BP (eIF4E-binding protein; encoded by the Thor gene). cap 156-159 thor Drosophila melanogaster 183-188 29166596-2 2017 Here, we use a Drosophila model to demonstrate that antimicrobial peptide (AMP) production during infection is paradoxically stimulated by the inhibitor of cap-dependent translation, 4E-BP (eIF4E-binding protein; encoded by the Thor gene). cap 156-159 thor Drosophila melanogaster 190-211 29049213-7 2017 HCAP was associated with not only an increased rate of CAP-DRPs (HCAP, 19.8%; CAP, 4.0%; P < .001) but also an increased rate of inappropriate initial antibiotic therapy (IIAT) (HCAP, 16.8%; CAP, 4.6%; P < .001). cap 1-4 structural maintenance of chromosomes 3 Homo sapiens 65-69 29049213-7 2017 HCAP was associated with not only an increased rate of CAP-DRPs (HCAP, 19.8%; CAP, 4.0%; P < .001) but also an increased rate of inappropriate initial antibiotic therapy (IIAT) (HCAP, 16.8%; CAP, 4.6%; P < .001). cap 1-4 structural maintenance of chromosomes 3 Homo sapiens 65-69 29049213-7 2017 HCAP was associated with not only an increased rate of CAP-DRPs (HCAP, 19.8%; CAP, 4.0%; P < .001) but also an increased rate of inappropriate initial antibiotic therapy (IIAT) (HCAP, 16.8%; CAP, 4.6%; P < .001). cap 55-58 structural maintenance of chromosomes 3 Homo sapiens 0-4 29049213-7 2017 HCAP was associated with not only an increased rate of CAP-DRPs (HCAP, 19.8%; CAP, 4.0%; P < .001) but also an increased rate of inappropriate initial antibiotic therapy (IIAT) (HCAP, 16.8%; CAP, 4.6%; P < .001). cap 55-58 structural maintenance of chromosomes 3 Homo sapiens 65-69 29049213-7 2017 HCAP was associated with not only an increased rate of CAP-DRPs (HCAP, 19.8%; CAP, 4.0%; P < .001) but also an increased rate of inappropriate initial antibiotic therapy (IIAT) (HCAP, 16.8%; CAP, 4.6%; P < .001). cap 55-58 structural maintenance of chromosomes 3 Homo sapiens 65-69 29049213-8 2017 HCAP was also associated with an increased 28-day mortality rate compared with CAP (HCAP, 14.5%; CAP, 6.3%; P < .001). cap 1-4 structural maintenance of chromosomes 3 Homo sapiens 84-88 28468879-9 2017 The low dependence on eIF4E suggests that viral mRNAs may engage yet-unknown noncanonical host factors for a cap-dependent initiation mechanism.IMPORTANCE Several members of the Arenaviridae family cause serious hemorrhagic fevers in humans. cap 109-112 eukaryotic translation initiation factor 4E Homo sapiens 22-27 28487484-3 2017 Here we show that the cap-binding eIF4E-homologous protein 4EHP is an integral component of the miRNA-mediated silencing machinery. cap 22-25 eukaryotic translation initiation factor 4E Homo sapiens 34-39 28487484-3 2017 Here we show that the cap-binding eIF4E-homologous protein 4EHP is an integral component of the miRNA-mediated silencing machinery. cap 22-25 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 59-63 28064055-4 2017 In hepatic injury model mice, sCAP could significantly reduce ALT, AST and ALP contents and raised TP content in serum, significantly reduce MDA and ROS contents and raised SOD and T-AOC activities in liver homogenate in comparison with CAP; obviously relieve the pathological changes of liver and significantly inhibit the expressions of p-ERK, p-JNK and p-p38 protein as compared with those in model control group. cap 31-34 solute carrier family 17 (anion/sugar transporter), member 5 Mus musculus 67-70 28064055-4 2017 In hepatic injury model mice, sCAP could significantly reduce ALT, AST and ALP contents and raised TP content in serum, significantly reduce MDA and ROS contents and raised SOD and T-AOC activities in liver homogenate in comparison with CAP; obviously relieve the pathological changes of liver and significantly inhibit the expressions of p-ERK, p-JNK and p-p38 protein as compared with those in model control group. cap 31-34 alopecia, recessive Mus musculus 75-78 28064055-4 2017 In hepatic injury model mice, sCAP could significantly reduce ALT, AST and ALP contents and raised TP content in serum, significantly reduce MDA and ROS contents and raised SOD and T-AOC activities in liver homogenate in comparison with CAP; obviously relieve the pathological changes of liver and significantly inhibit the expressions of p-ERK, p-JNK and p-p38 protein as compared with those in model control group. cap 31-34 eukaryotic translation initiation factor 2 alpha kinase 3 Mus musculus 339-344 28064055-4 2017 In hepatic injury model mice, sCAP could significantly reduce ALT, AST and ALP contents and raised TP content in serum, significantly reduce MDA and ROS contents and raised SOD and T-AOC activities in liver homogenate in comparison with CAP; obviously relieve the pathological changes of liver and significantly inhibit the expressions of p-ERK, p-JNK and p-p38 protein as compared with those in model control group. cap 31-34 mitogen-activated protein kinase 14 Mus musculus 358-361 27647922-4 2016 Importantly, we found that decreasing cap-dependent translation by expressing a constitutively active mutant of the translational repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) prevents neuronal misplacement and soma enlargement, while partially rescuing dendritic hypertrophy induced by hyperactive mTORC1. cap 38-41 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 169-189 27696794-9 2017 RESULTS: Several novel traits of OA chondrocytes were identified, including up-regulation of the serine/threonine kinases Akt-2 and Akt-3 at the posttranscriptional level and an increased rate of total protein synthesis, likely attributable to inactivation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1), a known repressor of cap-dependent translation. cap 341-344 AKT serine/threonine kinase 2 Homo sapiens 122-127 27749759-6 2017 The sepsis-induced increase in 4E-BP1 was associated with enhanced formation of the eIF4E-eIF4G active cap-dependent complex, while the increased S6K1 was associated with increased phosphorylation of downstream targets S6 and eIF4B. cap 103-106 eukaryotic translation initiation factor 4E binding protein 1 Mus musculus 31-37 27749759-6 2017 The sepsis-induced increase in 4E-BP1 was associated with enhanced formation of the eIF4E-eIF4G active cap-dependent complex, while the increased S6K1 was associated with increased phosphorylation of downstream targets S6 and eIF4B. cap 103-106 eukaryotic translation initiation factor 4E Mus musculus 84-89 28314261-8 2017 CAP-treated cells exhibited an increase of PRX 1 and 2 10 sec after treatment. cap 0-3 peroxiredoxin 1 Homo sapiens 43-54 27729194-4 2016 Results from our studies suggest that quinazoline-based VCP inhibitors initiate G1 cell cycle arrest, attenuate cap-dependent translation and induce programmed cell death via the intrinsic and the extrinsic modes of apoptosis. cap 112-115 valosin containing protein Homo sapiens 56-59 27647922-4 2016 Importantly, we found that decreasing cap-dependent translation by expressing a constitutively active mutant of the translational repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) prevents neuronal misplacement and soma enlargement, while partially rescuing dendritic hypertrophy induced by hyperactive mTORC1. cap 38-41 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 191-197 27647922-4 2016 Importantly, we found that decreasing cap-dependent translation by expressing a constitutively active mutant of the translational repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) prevents neuronal misplacement and soma enlargement, while partially rescuing dendritic hypertrophy induced by hyperactive mTORC1. cap 38-41 CREB regulated transcription coactivator 1 Mus musculus 322-328 27002144-2 2016 Under conditions of extreme oxygen depletion (hypoxia), human cells repress eIF4E and switch to an alternative cap-dependent translation mediated by a homolog of eIF4E, eIF4E2. cap 111-114 eukaryotic translation initiation factor 4E Homo sapiens 162-167 27016579-5 2016 CAP exposure also suppressed circulating levels of EPCs (Flk-1(+)/Sca-1(+) cells), while enhancing the bone marrow abundance of these cells. cap 0-3 kinase insert domain protein receptor Mus musculus 57-62 27016579-5 2016 CAP exposure also suppressed circulating levels of EPCs (Flk-1(+)/Sca-1(+) cells), while enhancing the bone marrow abundance of these cells. cap 0-3 ataxin 1 Mus musculus 66-71 27002144-2 2016 Under conditions of extreme oxygen depletion (hypoxia), human cells repress eIF4E and switch to an alternative cap-dependent translation mediated by a homolog of eIF4E, eIF4E2. cap 111-114 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 169-175 27141928-2 2016 Although cap-dependent translation is globally inhibited during ischemia, the mRNAs encoding two important proangiogenic growth factors, vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2), are translated at early time points in ischemic muscle. cap 9-12 fibroblast growth factor 2 Mus musculus 211-216 27114554-12 2016 Cap-dependent changes to the structure of eIF4E underpin this selectivity. cap 0-3 eukaryotic translation initiation factor 4E Homo sapiens 42-47 27056897-8 2016 Furthermore, IS inhibits the cap-dependent translation of c-myc through mTORC1-4E-BP1 axis which links the relationship between mRNA translation and glycolysis. cap 29-32 MYC proto-oncogene, bHLH transcription factor Homo sapiens 58-63 27056897-8 2016 Furthermore, IS inhibits the cap-dependent translation of c-myc through mTORC1-4E-BP1 axis which links the relationship between mRNA translation and glycolysis. cap 29-32 CREB regulated transcription coactivator 1 Mus musculus 72-78 27056897-8 2016 Furthermore, IS inhibits the cap-dependent translation of c-myc through mTORC1-4E-BP1 axis which links the relationship between mRNA translation and glycolysis. cap 29-32 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 79-85 26942679-6 2016 P97/DAP5, a homolog of canonical translation factor, eIF4G, which lacks PABP- and cap binding complex-interacting domains, is required for activation, and thereby for the oocyte immature state. cap 82-85 eukaryotic translation initiation factor 4 gamma 2 Homo sapiens 0-3 26762571-9 2016 For patients discharged from the ED with CAP, diagnostic utilization rates for blood culture, CBC, CRP, and CXR were higher after guideline publication compared with expected utilization rates without guidelines. cap 41-44 C-reactive protein Homo sapiens 99-102 26942679-6 2016 P97/DAP5, a homolog of canonical translation factor, eIF4G, which lacks PABP- and cap binding complex-interacting domains, is required for activation, and thereby for the oocyte immature state. cap 82-85 eukaryotic translation initiation factor 4 gamma 2 Homo sapiens 4-8 26942679-6 2016 P97/DAP5, a homolog of canonical translation factor, eIF4G, which lacks PABP- and cap binding complex-interacting domains, is required for activation, and thereby for the oocyte immature state. cap 82-85 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 53-58 26648341-5 2016 RESULTS: In T2DM and T2DM+CAP groups, levels of both TLR2/4 protein and mRNA in PBMC were decreased compared with controls (P <0.05), with lower levels observed in the T2DM+CAP group in comparison with T2DM patients (P <0.05). cap 26-29 toll like receptor 2 Homo sapiens 53-59 27735909-7 2016 The presence of CAP in a patient with CDHF resulted in an increase in mortality rates (OR 13.5; p < 0.001); moreover, the highest risk of a fatal outcome was noted on day 1 of hospitalization (12.7%). cap 16-19 olfactory receptor family 10 subfamily T member 2 Homo sapiens 87-92 25839159-2 2015 We demonstrate here that the cap bound fraction from lymphoma cells was enriched with eIF4G and eIF4E indicating that lymphoma cells exist in an activated translational state. cap 29-32 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 86-91 25839159-2 2015 We demonstrate here that the cap bound fraction from lymphoma cells was enriched with eIF4G and eIF4E indicating that lymphoma cells exist in an activated translational state. cap 29-32 eukaryotic translation initiation factor 4E Homo sapiens 96-101 26370510-6 2015 Overexpression of an eIF4E2 mutant that lost the cap-binding activity also impaired TTP"s activity, suggesting that the cap-binding activity of eIF4E2 is important in TTP-mediated translational repression. cap 49-52 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 21-27 26370510-6 2015 Overexpression of an eIF4E2 mutant that lost the cap-binding activity also impaired TTP"s activity, suggesting that the cap-binding activity of eIF4E2 is important in TTP-mediated translational repression. cap 49-52 ZFP36 ring finger protein Homo sapiens 84-87 26370510-6 2015 Overexpression of an eIF4E2 mutant that lost the cap-binding activity also impaired TTP"s activity, suggesting that the cap-binding activity of eIF4E2 is important in TTP-mediated translational repression. cap 49-52 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 144-150 26370510-6 2015 Overexpression of an eIF4E2 mutant that lost the cap-binding activity also impaired TTP"s activity, suggesting that the cap-binding activity of eIF4E2 is important in TTP-mediated translational repression. cap 49-52 ZFP36 ring finger protein Homo sapiens 167-170 26370510-6 2015 Overexpression of an eIF4E2 mutant that lost the cap-binding activity also impaired TTP"s activity, suggesting that the cap-binding activity of eIF4E2 is important in TTP-mediated translational repression. cap 120-123 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 21-27 26370510-6 2015 Overexpression of an eIF4E2 mutant that lost the cap-binding activity also impaired TTP"s activity, suggesting that the cap-binding activity of eIF4E2 is important in TTP-mediated translational repression. cap 120-123 ZFP36 ring finger protein Homo sapiens 84-87 26370510-6 2015 Overexpression of an eIF4E2 mutant that lost the cap-binding activity also impaired TTP"s activity, suggesting that the cap-binding activity of eIF4E2 is important in TTP-mediated translational repression. cap 120-123 eukaryotic translation initiation factor 4E family member 2 Homo sapiens 144-150 26370510-6 2015 Overexpression of an eIF4E2 mutant that lost the cap-binding activity also impaired TTP"s activity, suggesting that the cap-binding activity of eIF4E2 is important in TTP-mediated translational repression. cap 120-123 ZFP36 ring finger protein Homo sapiens 167-170 26108756-5 2015 Consistent with its BP effect, chronic exposure to CAP significantly decreased cardiac stroke volume and output in SHR, accompanied by increased heart weight and increased cardiac expression of hypertrophic markers ACTA1 and MYH7. cap 51-54 actin, alpha 1, skeletal muscle Rattus norvegicus 215-220 26108756-5 2015 Consistent with its BP effect, chronic exposure to CAP significantly decreased cardiac stroke volume and output in SHR, accompanied by increased heart weight and increased cardiac expression of hypertrophic markers ACTA1 and MYH7. cap 51-54 myosin heavy chain 7 Rattus norvegicus 225-229