PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23543107-15	2013	Maintenance of PCO2 level and CO2 responsiveness, especially with lowered 5-HT2 activity, may be important for preventing repetitive OSA.	pco2	15-19	hypothermia due to alcohol sensitivity 2	Mus musculus	76-79
24005470-9	2013	NBCn1, which expresses in different kidney cell types, was upregulated by 24-h high-Pco2 exposure of HEK cells, and this upregulation was accompanied by increased NBCn1-mediated HCO3(-) transport.	pco2	84-88	solute carrier family 4 member 7	Homo sapiens	0-5
24032393-5	2013	Decreases in arterial pH and increases in arterial pCO2 stimulate AVP release by the Supraoptic and Paraventricular Nuclei.	pco2	51-55	arginine vasopressin	Homo sapiens	66-69
24220509-5	2013	Introducing the carbamylation motif into Cx31 created a mutant hemichannel (mCx31) that was opened by increases in PCO2.	pco2	115-119	gap junction protein beta 3	Homo sapiens	41-45
23302768-8	2013	The Ang-2: Ang-1 ratio was significantly associated with early death (OR, 2.602; 95% CI, 1.106-6.117; p=0.028) after adjusting for plasma levels of paraquat, age, PCO2, and creatinine.	pco2	163-167	angiopoietin 2	Homo sapiens	4-9
23375560-7	2013	Hot water bathing induced a significant reduction in the partial pressure of CO2 (pCO2) and respiratory alkalosis in the WT and Scn1a mutant rats.	pco2	82-86	sodium voltage-gated channel alpha subunit 1	Rattus norvegicus	128-133
23626849-9	2013	The observed variations of pCO2 were explained through a statistical model considering wind direction and speed together with PAR irradiance.	pco2	27-31	jumping translocation breakpoint	Homo sapiens	126-129
23347056-0	2013	Lowering of elevated tissue PCO2 in a hemorrhagic shock rat model after reinfusion of a novel nanobiotechnological polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase that is an oxygen and a carbon dioxide carrier with enhanced antioxidant properties.	pco2	28-32	catalase	Rattus norvegicus	151-159
23302768-8	2013	The Ang-2: Ang-1 ratio was significantly associated with early death (OR, 2.602; 95% CI, 1.106-6.117; p=0.028) after adjusting for plasma levels of paraquat, age, PCO2, and creatinine.	pco2	163-167	angiopoietin 1	Homo sapiens	11-16
23762985-2	2013	Simvastatin at a concentration of 100 ng/ml increases p50 (the blood pO2 corresponding to its 50% oxygen saturation) at real values of pH and pCO2 from 39.53 + 2.41 (p <0.05) to 36.60 (36, 40, 37, 60) (p <0.05) mm Hg.	pco2	142-146	nuclear factor kappa B subunit 1	Homo sapiens	54-57
23128844-11	2013	Capillary pCO2 decreased in patients with IPF and COPD.	pco2	10-14	COPD	Homo sapiens	50-54
24089653-13	2013	Compared to PC1, PC2 exhibited lower pH, pO2, and Na(+) levels, a higher PLT count, and increased pCO2, K(+), Lac, and CD62P expression levels.	pco2	98-102	polycystin 2, transient receptor potential cation channel	Homo sapiens	17-20
21097994-4	2011	Blockade of the AT1 receptor decreased arterial blood oxygenation and pH and increased blood pCO2, haemoglobin and lactate, and plasma cortisol and IGF-II.	pco2	93-97	type-1 angiotensin II receptor	Ovis aries	16-19
20736419-2	2010	Given the localization of connexin 26 (Cx26) to the chemosensing areas of the medulla, we have tested in a heterologous expression system (HeLa cells) whether Cx26 may be sensitive to changes in PCO2.	pco2	195-199	gap junction protein beta 2	Homo sapiens	159-163
21047793-0	2011	Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity.	pco2	89-93	potassium inwardly-rectifying channel, subfamily J, member 16	Mus musculus	24-30
21047793-0	2011	Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity.	pco2	89-93	potassium inwardly-rectifying channel, subfamily J, member 16	Mus musculus	42-48
20736419-3	2010	Cx26 responded to an increase in PCO2 at constant extracellular pH by opening and to a decrease in PCO2 by closing.	pco2	33-37	gap junction protein beta 2	Homo sapiens	0-4
20736419-3	2010	Cx26 responded to an increase in PCO2 at constant extracellular pH by opening and to a decrease in PCO2 by closing.	pco2	99-103	gap junction protein beta 2	Homo sapiens	0-4
20736419-4	2010	Furthermore, Cx26 was partially activated at a physiological PCO2 of around 40 mmHg.	pco2	61-65	gap junction protein beta 2	Homo sapiens	13-17
20736419-5	2010	Cx26 in isolated patches responded to changes in PCO2, suggesting direct CO(2) sensitivity of the hemichannel to CO(2).	pco2	49-53	gap junction protein beta 2	Homo sapiens	0-4
20736419-8	2010	The closely related beta connexins Cx30 and Cx32 also displayed sensitivity to changes in PCO2, but with slightly different characteristics from Cx26.	pco2	90-94	gap junction protein beta 6	Homo sapiens	35-39
20736419-8	2010	The closely related beta connexins Cx30 and Cx32 also displayed sensitivity to changes in PCO2, but with slightly different characteristics from Cx26.	pco2	90-94	gap junction protein beta 1	Homo sapiens	44-48
20736421-11	2010	We therefore propose that Cx26-mediated release of ATP in response to changes in PCO2 is an important mechanism contributing to central respiratory chemosensitivity.	pco2	81-85	gap junction protein beta 2	Homo sapiens	26-30
16920100-3	2006	Hypercapnia (arterial pCO2 50-60 mm Hg) increased rCBF by 2.8+/-1.0%/mm Hg (n = 34).	pco2	22-26	CCAAT/enhancer binding protein zeta	Rattus norvegicus	50-54
18004228-1	2008	Mucosal pH (pHi) is influenced by local perfusion and metabolism (mucosal-arterial pCO2 gradient, DeltapCO2), systemic metabolic acidosis (arterial bicarbonate), and respiration (arterial pCO2).	pco2	83-87	glucose-6-phosphate isomerase	Homo sapiens	12-15
18004228-1	2008	Mucosal pH (pHi) is influenced by local perfusion and metabolism (mucosal-arterial pCO2 gradient, DeltapCO2), systemic metabolic acidosis (arterial bicarbonate), and respiration (arterial pCO2).	pco2	103-107	glucose-6-phosphate isomerase	Homo sapiens	12-15
24150010-13	2009	There were also significant differences between SB and B10 in PCO2 immediately after exercise.	pco2	62-66	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	55-58
16516565-6	2006	Arterial PCO2 decreased by 4 +/- 2 mmHg (P < 0.05) between sets 1 and 2, which did not reduce further in set 3.	pco2	9-13	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	62-74
14736638-6	2004	pH, PCO2, BE, and HCO3 were all significantly correlated in ABG, VBG, and CBG.	pco2	4-8	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	74-77
17187018-8	2006	Cord blood IGFBP-3 levels were positively correlated with first and 5th minutes Apgar scores, cord blood arterial pH, pCO2, ABE, HCO3, sO2, and also negatively correlated with cord CO2 and cord lactate levels.	pco2	118-122	insulin like growth factor binding protein 3	Homo sapiens	11-18
16235474-13	2005	We found a relationship between erythropoietin concentration and biological markers of tissue hypoperfusion i.e. lactate levels or PCO2 gap.	pco2	131-135	erythropoietin	Homo sapiens	32-46
16594477-2	2005	The technique utilizes the PCO2 of the gastric fluid to calculate intramucosal pH (pHi).	pco2	27-31	glucose-6-phosphate isomerase	Homo sapiens	83-86
12973171-13	2003	A positive relationship was demonstrated between plasma levels of tumor necrosis factor-alpha and interleukin-6 and the PCO2 gap throughout the study.	pco2	120-124	tumor necrosis factor	Homo sapiens	66-93
14718755-4	2004	Cord serum CRP correlated positively with amniotic fluid erythropoietin and umbilical artery pCO2.	pco2	93-97	C-reactive protein	Homo sapiens	11-14
12973171-13	2003	A positive relationship was demonstrated between plasma levels of tumor necrosis factor-alpha and interleukin-6 and the PCO2 gap throughout the study.	pco2	120-124	interleukin 6	Homo sapiens	98-111
11673226-15	2001	Moreover, rhythmogenesis is supported through NHE3 inhibition by lowering the threshold PCO2 for central apnea.	pco2	88-92	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	46-50
11927646-0	2002	Ambient pCO2 modulates intracellular pH, intracellular oxidant generation, and interleukin-8 secretion in human neutrophils.	pco2	8-12	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
11199364-9	2000	Acidified peptone buffered with NaHCO3 to neutrality (pH 6.9, PCO2 approximately 600 mmHg) increased serum gastrin by 166% +/- 29%.	pco2	62-66	gastrin	Homo sapiens	107-114
11316651-1	2001	To determine the influence of changes in gastric juice pH due to intravenous administration of pentagastrin and omeprazole on intramucosal regional PCO2 (Pr(CO2)), we investigated 17 healthy human volunteers.	pco2	148-152	complement C2	Homo sapiens	154-161
11380523-8	2001	Increasing PCO2 from 5 to 20% resulted in a rapid decrease in pHi.	pco2	11-15	glucose-6-phosphate isomerase	Rattus norvegicus	62-65
11380523-11	2001	Increasing PCO2 under sodium-free conditions also resulted in a drop of pHi that was, however, not fully reversible, suggesting involvement of the Na+/H+ exchanger in the regulation of pHi in the intact organ.	pco2	11-15	glucose-6-phosphate isomerase	Rattus norvegicus	72-75
11380523-11	2001	Increasing PCO2 under sodium-free conditions also resulted in a drop of pHi that was, however, not fully reversible, suggesting involvement of the Na+/H+ exchanger in the regulation of pHi in the intact organ.	pco2	11-15	glucose-6-phosphate isomerase	Rattus norvegicus	185-188
10790154-17	2000	These results therefore indicate that the Kir4.1 channel is inhibited during hypercapnia by a decrease in intracellular pH, and the coexpression of Kir4.1 with Kir5.1 greatly enhances channel sensitivity to CO2/pH and may enable cells to detect both increases and decreases in PCO2 and intracellular pH at physiological levels.	pco2	277-281	potassium inwardly rectifying channel subfamily J member 10 S homeolog	Xenopus laevis	42-48
10981577-6	2000	RESULTS: Regional PCO2 (Pr CO2) increased significantly in the intestinal region, in the small intestine, only during the SMA clamping.	pco2	18-22	PCO2	Sus scrofa	24-30
10966271-12	2000	CONCLUSIONS: During hypothermia, intraosseous P(CO2) values were predictable for mixed venous Pco2 and arterial P(CO2).	pco2	94-98	complement C2	Homo sapiens	46-51
10790154-17	2000	These results therefore indicate that the Kir4.1 channel is inhibited during hypercapnia by a decrease in intracellular pH, and the coexpression of Kir4.1 with Kir5.1 greatly enhances channel sensitivity to CO2/pH and may enable cells to detect both increases and decreases in PCO2 and intracellular pH at physiological levels.	pco2	277-281	potassium inwardly rectifying channel subfamily J member 10 S homeolog	Xenopus laevis	148-154
10790154-17	2000	These results therefore indicate that the Kir4.1 channel is inhibited during hypercapnia by a decrease in intracellular pH, and the coexpression of Kir4.1 with Kir5.1 greatly enhances channel sensitivity to CO2/pH and may enable cells to detect both increases and decreases in PCO2 and intracellular pH at physiological levels.	pco2	277-281	potassium inwardly rectifying channel subfamily J member 16 S homeolog	Xenopus laevis	160-166
10793443-10	2000	Ascent to 4,000 m above sea level induced a significant decrease in arterial pO2 (10.7 +/- 1.1 vs 5.5 +/- 0.3 kPa), pCO2 (5.3 +/- 0.3 vs 4.7 +/- 0.4 kPa), oxygen saturation measured by arterial blood gas analysis (95.5% +/- 1.2% vs 79.1% +/- 2.5%), and increase in pH (7.39 +/- 0.02 vs 7.45 +/- 0.04) (P < 0.0001).	pco2	116-120	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	24-27
10381605-3	1999	During ACMV, end-tidal PCO2 (PET,CO2) was either held at normocapnic levels (PET,CO2, 0.6-1.1 mmHg > control) by adding CO2 to the inspirate, or it was allowed to fall (hypocapnia).	pco2	23-27	complement C2	Homo sapiens	29-36
10626068-12	1999	In ET-1+/- mice, PCO2 tended to be higher and PO2 was significantly lower than corresponding values in ET-1+/+ mice.	pco2	17-21	endothelin 1	Mus musculus	3-7
10458575-2	1999	The incidence of cardiac arrhythmias was assessed in broiler chickens with either a relatively high carbon dioxide tension (PCO2) or a low PCO2 in their venous blood.	pco2	124-128	olfactory receptor	Gallus gallus	130-134
9852690-16	1998	When cardiac output increased, blood pH decreased due to increased Pco2 and decreased BE.	pco2	67-71	glucose-6-phosphate isomerase	Homo sapiens	37-39
9860472-11	1998	Jejunal intramucosal pH (pHi) was calculated every hour by the luminal PCO2, obtained with a balloon tonometer, and arterial bicarbonate concentration.	pco2	71-75	glucose-6-phosphate isomerase	Homo sapiens	25-28
9592070-2	1998	Hypercapnia (pCO2 80-100 mmHg) reduced pHi by 0.15 +/- 0.06 units and stimulated neuronal discharges.	pco2	13-17	glucose-6-phosphate isomerase	Rattus norvegicus	39-42
9792581-10	1998	Multiple regression analyses showed that arterial PCO2 was significantly correlated with SOT, LECT, and CI (r=0.51; r2=0.26; p<0.000001); the correlation became stronger considering only CSR patients (r=0.64; r2=0.4; p<0.001).	pco2	50-54	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
9488250-11	1998	In examining the determinants of pHi, the intramucosal-arterial PCO2 difference was improved after enalaprilat administration (27 +/- 6 to 17 +/- 3 mmHg, p = .04) while no difference was observed in arterial bicarbonate (19.5 +/- .7 to 19.7 +/- .8, p = .90).	pco2	64-68	glucose-6-phosphate isomerase	Homo sapiens	33-36
9488250-12	1998	Additionally, the change in pHi observed with enalaprilat correlated with predrug intramucosal-arterial PCO2 difference (r = .74, r2 = .55, p = .0005).	pco2	104-108	glucose-6-phosphate isomerase	Homo sapiens	28-31
8941519-6	1996	At peak of exercise, end-tidal PCO2 was much lower in Dan+ (35.9 +/- 1.6 Torr) than in Dan- (42.1 +/- 1.7 Torr; P < 0.02) and control (42.1 +/- 0.9 Torr; P < 0.005) subjects.	pco2	31-35	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
9316422-4	1997	Similarly, varying pHo by changing PCO2 at constant [HCO3-]o or changing [HCO3-]o at constant PCO2 led to rapid, monotonic changes in pHi.	pco2	35-39	glucose-6-phosphate isomerase	Rattus norvegicus	134-137
9071218-3	1997	RESULTS: Raising the partial pressure of CO2 (PCO2) from 5% to 10% or 20% acidified the medium, decreased the pHi, and relaxed the pericytes.	pco2	46-50	glucose-6-phosphate isomerase	Bos taurus	110-113
9071218-4	1997	Lowering the PCO2 from 5% to 0% or 2% alkalized the medium, raised the pHi, and contracted the pericytes.	pco2	13-17	glucose-6-phosphate isomerase	Bos taurus	71-74
9269415-4	1997	Using a computer simulation, the hypothesis was tested that [SID] = [SID Excess] ([SIDEx]), where [SIDEx] is the change in [SID] needed to restore pH to normal at normal PCO2.	pco2	170-174	N-acylsphingosine amidohydrolase 1	Homo sapiens	147-149
9120119-9	1996	Intramucosal pH (pHi) calculated from PCO2 air was significantly lower than that calculated from PCO2ss (7.26 +/- 0.23 vs 7.28 +/- 0.24, p = 0.0001).	pco2	38-42	glucose-6-phosphate isomerase	Homo sapiens	17-20
9120119-12	1996	CONCLUSION: We conclude that intraluminal PCO2 can be accurately determined in postoperative cardiac surgery patients by instilling air into the stomach and analyzing samples of gastric air on a standard blood gas machine, In comparison with saline tonometry, air tonometry consistently yields lower pHi values.	pco2	42-46	glucose-6-phosphate isomerase	Homo sapiens	300-303
9595536-1	1998	Endothelin-1 (ET-1) is produced by some tumor cells, but the dependence of this production on pO2 and pCO2, conditions relevant within the tumor microenvironment, has not been described.	pco2	102-106	endothelin 1	Homo sapiens	0-12
9441471-7	1997	It has been customary to calculate so-called interstitial pH (pHi) by incorporating the measured pCO2 in the tonometer and the HCO3- in an arterial blood gas in the Henderson-Hasselbalch equation.	pco2	97-101	glucose-6-phosphate isomerase	Homo sapiens	62-65
9316422-4	1997	Similarly, varying pHo by changing PCO2 at constant [HCO3-]o or changing [HCO3-]o at constant PCO2 led to rapid, monotonic changes in pHi.	pco2	94-98	glucose-6-phosphate isomerase	Rattus norvegicus	134-137
8661188-8	1996	For the same level of extracellular acidification, increases in PCO2 were more effective than acute decreases in HCO3- in acidifying pHi and eliciting disturbances in voltage-generating and ion permeability properties of the cell membranes.	pco2	64-68	glucose-6-phosphate isomerase	Homo sapiens	133-136
8674338-11	1996	CONCLUSIONS: This calibration procedure allows accurate measurement of Pco2 in aqueous samples using the Radiometer ABL2 electrode system, and should be applicable to other blood gas analyzers.	pco2	71-75	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	116-120
8764164-4	1996	In 21 mM HCO3-Ringer, increasing PCO2 from 20 to 70 mmHg decreased pHi from 7.51 to 7.03 and increased net Na flux (JnetNa) from 4.2 +/- 0.4 to 6.8 +/- 0.6 mu eq.cm-2.h-1.	pco2	33-37	glucose-6-phosphate isomerase	Rattus norvegicus	67-70
8984701-7	1996	There was an inverse correlation between PCO2 values and SP-A concentrations.	pco2	41-45	surfactant protein A1	Homo sapiens	57-61
8677271-12	1996	pHi recovery during elevated PCO2 was blocked by amiloride, H2DIDS, or Na+-free media.	pco2	29-33	glucose-6-phosphate isomerase	Homo sapiens	0-3
8848910-10	1996	IL-1 beta moderately decreased PCO2 in awake animals.	pco2	31-35	interleukin 1 beta	Rattus norvegicus	0-9
8693442-3	1996	Gastric pHi was calculated from the equation: pHi= 6.1 + log HCO3/(gastric PCO2 X 0.03).	pco2	75-79	glucose-6-phosphate isomerase	Homo sapiens	8-11
8680875-1	1996	Since high PCO in the dark works like hypoxia in the carotid body chemoreceptors and since hypoxia shows a stimulus interaction with CO2, it is hypothesized that high PCO will show a similar interaction with PCO2 in the chemosensory excitation in the dark.	pco2	208-212	PCOS1	Homo sapiens	167-170
8680875-8	1996	With high PCO, bright light promptly reduced the activity to baseline at all PCO2 levels.	pco2	77-81	PCOS1	Homo sapiens	10-13
8652331-2	1996	pHi was calculated from measurement of PCO2 in tonometered saline (TCO2).	pco2	39-43	glucose-6-phosphate isomerase	Homo sapiens	0-3
8625643-9	1996	Intrainstrumental comparison of the PCO2 determinations demonstrated an increase of 12.3 +/- 9.9% for ABL 2, 3.10 +/- 12.9% for Ciba Corning 288, and 101.2 +/- 31.5% for StatProfile 9 Plus with the phosphate buffered solution.	pco2	36-40	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	102-107
7861215-6	1995	Given the assumption that the PVI remained constant during alteration of PaCO2, the estimated blood volume change per torr change of PCO2 was calculated by the following equation: BVR = PVI x delta log(ICP)/delta PCO2, where BVR = blood volume reactivity.	pco2	133-137	biliverdin reductase A	Homo sapiens	180-183
8738394-9	1996	Changes in 1/AVDO2 after inducing pCO2 changes give a good estimate of changes in global CBF.	pco2	34-38	CCAAT enhancer binding protein zeta	Homo sapiens	89-92
7658458-11	1995	The NHE-3 abundance remained unchanged in high, normal, and low pCO2 tubules.	pco2	64-68	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	4-9
8683478-6	1996	End-tidal Pco2 (PET,CO2) was increased by altering the level of inspired CO2.	pco2	10-14	complement C2	Homo sapiens	16-23
7587811-1	1995	The finding of a high PCO2 in basally secreted pancreatic juice of man and dog raises the hypothesis of proton secretion from ductal epithelial cells presumably through a Na+/H+ exchanger.	pco2	22-26	solute carrier family 9 member A1	Canis lupus familiaris	171-187
7861215-6	1995	Given the assumption that the PVI remained constant during alteration of PaCO2, the estimated blood volume change per torr change of PCO2 was calculated by the following equation: BVR = PVI x delta log(ICP)/delta PCO2, where BVR = blood volume reactivity.	pco2	133-137	biliverdin reductase A	Homo sapiens	225-228
7861215-6	1995	Given the assumption that the PVI remained constant during alteration of PaCO2, the estimated blood volume change per torr change of PCO2 was calculated by the following equation: BVR = PVI x delta log(ICP)/delta PCO2, where BVR = blood volume reactivity.	pco2	213-217	biliverdin reductase A	Homo sapiens	180-183
8145170-6	1993	The PET,CO2 at which activation first occurred was defined as the CO2 recruitment threshold (PCO2,RT).	pco2	93-97	complement C2	Homo sapiens	4-11
8020795-1	1994	A high intragastric PCO2 (iPCO2), determined tonometrically, is the main factor participating in a low gastric intramucosal pH (pHi) and may point to gastric mucosal ischaemia.	pco2	20-24	glucose-6-phosphate isomerase	Homo sapiens	128-131
7872361-3	1995	pHi was measured, using the fluorescent probe BCECF (2",7"-bis-carboxyethyl-5,6-carboxyfluorescein), both in nominal absence of bicarbonate (Hepes solution, pH 7.4; n = 10) and in the presence of HCO3-/CO2 buffer system (pH 7.4, [HCO3-] 25 mM, pCO2 40 mm Hg; n = 6).	pco2	244-248	glucose-6-phosphate isomerase	Homo sapiens	0-3
8203605-3	1994	During hypercarbia (arterial PCO2 = 70 +/- 5 mmHg), rCBF to collateral-dependent cerebrum, measured with microspheres and identified using the shadow flow technique, decreased from 95 +/- 6 (mean +/- SE) to 71 +/- 9 ml.100 g-1.min-1 (P < 0.05), while flow to normal brain increased from 105 +/- 9 to 281 +/- 15 ml.100 g-1.min-1 (P < 0.05).	pco2	29-33	CCAAT/enhancer binding protein zeta	Rattus norvegicus	52-56
8178010-0	1993	The effects of nasal CPAP on transcutaneous PCO2 during non-REM sleep and REM sleep in patients with obstructive sleep apnea syndrome.	pco2	44-48	centromere protein J	Homo sapiens	21-25
8166793-7	1993	The predictor variable, pHi, was calculated using the following equation: 6.1 + log HCO3/(gastric PCO2 x 0.0307).	pco2	98-102	glucose-6-phosphate isomerase	Homo sapiens	24-27
8120819-15	1993	As PCO2 rose, the increase in rCBF to grey matter was approximately three times greater than that to white matter.	pco2	3-7	CCAAT/enhancer binding protein zeta	Rattus norvegicus	30-34
8120819-18	1993	Over the whole gCBF range a significant (P = 0.028) effect of increasing rCBF in the visual cortex ROI was found in response to opening the eyes; the effect of this activation on rCBF was not significantly dependent (P = 0.34) on the PCO2 (and hence gCBF) level.	pco2	234-238	CCAAT/enhancer binding protein zeta	Rattus norvegicus	73-77
8120819-19	1993	The effect of the activation on the rCBF was apparently "additive" to the rise of rCBF associated with PCO2-related gCBF increase.	pco2	103-107	CCAAT/enhancer binding protein zeta	Rattus norvegicus	36-40
8120819-19	1993	The effect of the activation on the rCBF was apparently "additive" to the rise of rCBF associated with PCO2-related gCBF increase.	pco2	103-107	CCAAT/enhancer binding protein zeta	Rattus norvegicus	82-86
8226519-0	1993	Sea-level PCO2 relates to ventilatory acclimatization at 4,300 m. There is considerable variation among individuals in the extent of, and the time required for, ventilatory acclimatization to altitude.	pco2	10-14	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
8117975-5	1993	Thus, P50 in preterm babies is varying during a day, it varies periodically, in some cases the variations are due to the changes in pCO2.	pco2	132-136	nuclear factor kappa B subunit 1	Homo sapiens	6-9
8226519-3	1993	Measurements in 37 healthy resting male subjects at sea level indicated a wide range (34-48 Torr) of end-tidal PCO2 values.	pco2	111-115	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	52-55
8226519-4	1993	When these subjects were taken to Pikes Peak, CO (4,300 m, barometric pressure 462 mmHg), the end-tidal PCO2 values measured on arrival and repeatedly over 19 days were correlated with the sea-level end-tidal PCO2.	pco2	104-108	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	189-192
8226519-4	1993	When these subjects were taken to Pikes Peak, CO (4,300 m, barometric pressure 462 mmHg), the end-tidal PCO2 values measured on arrival and repeatedly over 19 days were correlated with the sea-level end-tidal PCO2.	pco2	209-213	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	189-192
8226519-6	1993	Also, sea-level end-tidal PCO2 related to SaO2 after 19 days at 4,300 m. Twenty-six of the subjects had measurements of isocapnic hypoxic ventilatory response (HVR) at sea level.	pco2	26-30	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	6-9
8226519-8	1993	Thus both the PCO2 and the HVR as measured at sea level related to the extent of subsequent ventilatory acclimatization (decrease in end-tidal PCO2) and the level of oxygenation at altitude.	pco2	14-18	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	46-49
8226519-9	1993	The finding in our cohort of subjects that sea-level end-tidal PCO2 was inversely related to HVR raised the possibility that among individuals the magnitude of the hypoxic drive to breathe influenced the amount of ventilation at all altitudes, including sea level.	pco2	63-67	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	43-46
8226519-9	1993	The finding in our cohort of subjects that sea-level end-tidal PCO2 was inversely related to HVR raised the possibility that among individuals the magnitude of the hypoxic drive to breathe influenced the amount of ventilation at all altitudes, including sea level.	pco2	63-67	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	254-257
8229846-5	1993	The slopes of the relationship between minute ventilation (VI) and the increase of end tidal PCO2 (delta P(ET), CO2) were 3.27 +/- 0.23 and 2.76 +/- 0.24 1 min-1 mmHg-1 supine and upright, respectively.	pco2	93-97	CD59 molecule (CD59 blood group)	Homo sapiens	156-161
8330374-5	1993	Changes in pHi, with a constant pHo, were induced with NH4Cl or by changing PCO2.	pco2	76-80	glucose-6-phosphate isomerase	Rattus norvegicus	11-14
8131445-5	1993	Both before and after bypass, PVR increased significantly as PCO2 rose from 30 mm Hg to 50 mm Hg (p < 0.05).	pco2	61-65	PVR cell adhesion molecule	Homo sapiens	30-33
8391679-3	1993	Recordings made in the pyramidal layer of area CA1 in rat hippocampal slices showed that the deviation in the acid direction of the basal interstitial pH (pH0) from that of the perfusion solution was attributable to a higher PCO2 level within the tissue.	pco2	225-229	carbonic anhydrase 1	Rattus norvegicus	47-50
8131445-6	1993	The PVR returned to baseline as PCO2 was returned to 30 mm Hg.	pco2	32-36	PVR cell adhesion molecule	Homo sapiens	4-7
8384799-6	1993	When the Ringer PCO2 was increased from 20 to 34 mmHg, pHi decreased from 7.50 +/- 0.04 to 7.35 +/- 0.04 and net Na absorption increased from 2.4 +/- 0.7 to 3.7 +/- 0.7 mu eq.cm-2 x h-1.	pco2	16-20	glucose-6-phosphate isomerase	Rattus norvegicus	55-58
1628400-9	1992	Simulation of CO2 accumulation (increase of PCO2 in the surrounding atmosphere), as encountered in midmural ventricular layers during in vivo ischemia, produced a significant decrease of pHo (6.30 versus 6.64) and pHi (6.65 versus 6.93) at 14 minutes of ischemia.	pco2	44-48	glucose-6-phosphate isomerase	Oryctolagus cuniculus	214-217
8443857-2	1993	The minimum concentration of ET-1 (10(-10) M) needed to induce contractions was lower than that of acetylcholine (10(-7) M) and histamine (10(-7) M) at normal PCO2.	pco2	159-163	endothelin-1	Cavia porcellus	29-33
8443857-4	1993	In contrast, very low and moderately low PCO2 attenuated the contractions induced by ET-1, but high PCO2 potentiated those induced by a high concentration of ET-1.	pco2	41-45	endothelin-1	Cavia porcellus	85-89
8443857-4	1993	In contrast, very low and moderately low PCO2 attenuated the contractions induced by ET-1, but high PCO2 potentiated those induced by a high concentration of ET-1.	pco2	100-104	endothelin-1	Cavia porcellus	158-162
8443857-5	1993	Very low PCO2 with normal pH and with high pH attenuated the contractions caused by ET-1, whereas normal PCO2 with high pH did not.	pco2	9-13	endothelin-1	Cavia porcellus	84-88
8443857-6	1993	These results suggest that ET-1-induced airway smooth muscle contraction can be modified by PCO2 per se.	pco2	92-96	endothelin-1	Cavia porcellus	27-31
8443857-7	1993	Aspirin and indomethacin potentiated the responses to ET-1 at very low PCO2 more than at normal PCO2, but attenuated the responses to low concentration of ET-1 at high PCO2.	pco2	71-75	endothelin-1	Cavia porcellus	54-58
8443857-7	1993	Aspirin and indomethacin potentiated the responses to ET-1 at very low PCO2 more than at normal PCO2, but attenuated the responses to low concentration of ET-1 at high PCO2.	pco2	96-100	endothelin-1	Cavia porcellus	54-58
8443857-7	1993	Aspirin and indomethacin potentiated the responses to ET-1 at very low PCO2 more than at normal PCO2, but attenuated the responses to low concentration of ET-1 at high PCO2.	pco2	96-100	endothelin-1	Cavia porcellus	54-58
8443857-8	1993	These results also suggest that cyclooxygenase-related eicosanoids are involved in the effects of PCO2 on ET-1-induced contractions.	pco2	98-102	endothelin-1	Cavia porcellus	106-110
1400642-6	1992	The increased velocities during CBF measurements cannot be fully explained by the moderate but significant PCO2 increase.	pco2	107-111	CCAAT/enhancer binding protein zeta	Rattus norvegicus	32-35
1400642-8	1992	The effect of mental activation and PCO2 differences should therefore be considered when comparing the results of repeated velocity and CBF measurements.	pco2	36-40	CCAAT/enhancer binding protein zeta	Rattus norvegicus	136-139
1421777-4	1992	In humans, solutions enriched with BCAA have decreased PCO2 and stimulated the ventilatory response to hypercapnia, thereby corresponding to an enhanced ventilatory sensitivity with the administration of BCAA.	pco2	55-59	AT-rich interaction domain 4B	Homo sapiens	35-39
1812405-3	1991	bolus injection of protirelin tartrate (TRH-T, 4 mg/kg), which produces a prompt and sustained reversal of the shock condition, caused a rapid increase in venous pO2, pCO2 and SO2; on the other hand, arterial and venous pH, bicarbonate and BE continued to decrease--and venous lactate to increase during the first few minutes after treatment.	pco2	167-171	thyrotropin releasing hormone	Rattus norvegicus	40-43
1562381-9	1992	The P300 latency was well correlated with the PCO2, PO2, pH.	pco2	46-50	E1A binding protein p300	Homo sapiens	4-8
1822566-4	1991	Simulated respiratory acidosis and alkalosis (i.e. changes in PCO2 at constant HCO3-) led to rapid (half-time t0.5 = 3 s) monotonic changes in pHi.	pco2	62-66	glucose-6-phosphate isomerase	Rattus norvegicus	143-146
1822566-10	1991	Changes in PCO2 at constant pHo (i.e. simultaneously changing HCO3-) caused rapid transient changes in pHi but did not significantly affect steady-state pHi over the range 1-10% CO2.	pco2	11-15	glucose-6-phosphate isomerase	Rattus norvegicus	103-106
1822566-12	1991	When PCO2 was held constant (5%), changing HCO3- and thus pHo (i.e. a simulated metabolic acidosis/alkalosis) led to much slower changes in pHi (t0.5 approximately 1 min).	pco2	5-9	glucose-6-phosphate isomerase	Rattus norvegicus	140-143
1822566-14	1991	Therefore, over the range of pHo, PCO2 and [HCO3-]o tested, steady-state pHi appeared to be a unique function of pHo and independent of PCO2 and [HCO3-]o.	pco2	34-38	glucose-6-phosphate isomerase	Rattus norvegicus	73-76
1822566-14	1991	Therefore, over the range of pHo, PCO2 and [HCO3-]o tested, steady-state pHi appeared to be a unique function of pHo and independent of PCO2 and [HCO3-]o.	pco2	136-140	glucose-6-phosphate isomerase	Rattus norvegicus	73-76
1822566-19	1991	The close correlation between the effects of changing pHo, PCO2 and [HCO3-]o on pHi and on CSN discharge suggests that a change in type-I cell pHi is the first step in the chemoreception of blood pH by the carotid body.	pco2	59-63	glucose-6-phosphate isomerase	Rattus norvegicus	80-83
1822566-19	1991	The close correlation between the effects of changing pHo, PCO2 and [HCO3-]o on pHi and on CSN discharge suggests that a change in type-I cell pHi is the first step in the chemoreception of blood pH by the carotid body.	pco2	59-63	glucose-6-phosphate isomerase	Rattus norvegicus	143-146
1903268-5	1991	A reduced urinary PCO2 is commonly found in dRTA but is not specific for the syndrome and may be accounted for by tubular defects other than those involving reduced distal hydrogen ion secretion.	pco2	18-22	rta	Drosophila melanogaster	44-48
1764140-7	1991	Marked regional variability in the CBF/PCO2 response was observed, ranging from 0.5-5.5 ml/min/100 gm/torr PCO2.	pco2	107-111	CCAAT enhancer binding protein zeta	Homo sapiens	35-38
1764140-8	1991	In the 2 patients who died, the CBF/PCO2 was decreased (1.2 ml/min/100 gm/torr PCO2) compared to the 2 patients who survived (2.1 ml/min/100 gm/torr PCO2).	pco2	36-40	CCAAT enhancer binding protein zeta	Homo sapiens	32-35
1764140-8	1991	In the 2 patients who died, the CBF/PCO2 was decreased (1.2 ml/min/100 gm/torr PCO2) compared to the 2 patients who survived (2.1 ml/min/100 gm/torr PCO2).	pco2	79-83	CCAAT enhancer binding protein zeta	Homo sapiens	32-35
1764140-8	1991	In the 2 patients who died, the CBF/PCO2 was decreased (1.2 ml/min/100 gm/torr PCO2) compared to the 2 patients who survived (2.1 ml/min/100 gm/torr PCO2).	pco2	79-83	CCAAT enhancer binding protein zeta	Homo sapiens	32-35
2022727-5	1991	Decreased PCO2 results in increased pHi associated with activation of Cl-/HCO3- exchange and partial recovery of pHi.	pco2	10-14	glucose-6-phosphate isomerase	Oryctolagus cuniculus	36-39
2022727-5	1991	Decreased PCO2 results in increased pHi associated with activation of Cl-/HCO3- exchange and partial recovery of pHi.	pco2	10-14	glucose-6-phosphate isomerase	Oryctolagus cuniculus	113-116
1989762-7	1991	MEASUREMENTS AND MAIN RESULTS: Gastric pHi was calculated from the arterial (HCO3-) and the tonometrically determined intraluminal PCO2 using the Henderson-Hasselbalch equation.	pco2	131-135	glucose-6-phosphate isomerase	Homo sapiens	39-42
1910074-4	1991	A highly significant negative correlation was found between cCa2+ and base excess (BE) (r = -0.81, P less than 0.0001), and between cCa2+ and carbon dioxide tension (PCO2) (r = 0.71, P less than 0.002).	pco2	166-170	crystallin beta B2	Homo sapiens	132-136
1908259-2	1991	As arterial PCO2 was elevated, PI was decreased and color imaging of CBF from basilar artery to anterior cerebral artery were improved in sagittal view.	pco2	12-16	CCAAT enhancer binding protein zeta	Homo sapiens	69-72
1909316-11	1991	During hyperventilation, which lowered arterial PCO2 and increased pH of the blood, the average PO2 decreased in proportion to the decrease in arterial PCO2.	pco2	48-52	PO2	Sus scrofa	96-99
1909316-11	1991	During hyperventilation, which lowered arterial PCO2 and increased pH of the blood, the average PO2 decreased in proportion to the decrease in arterial PCO2.	pco2	152-156	PO2	Sus scrofa	96-99
1909316-12	1991	For example, hyperventilation, which decreased arterial PCO2 from its normal value of 40 Torr to 10 Torr, caused a rapid (within 5 min) decrease in PO2 in the blood of capillaries and veins to approximately one-third of normal.	pco2	56-60	PO2	Sus scrofa	148-151
2114660-0	1990	Acute changes in osmolality and renin and respiratory control of arterial PCO2 and [H+].	pco2	74-78	renin	Canis lupus familiaris	32-37
2077961-4	1990	It has been shown that the main factors responsible for P50 changes in patients with uncomplicated postoperative period are Bohr"s effect (i. e. the impact of pH and pCO2) and the body temperature.	pco2	166-170	nuclear factor kappa B subunit 1	Homo sapiens	56-59
2155541-4	1990	pHi fell by approximately 0.17 when luminal [HCO3-] was lowered to 5 mM at fixed PCO2 (i.e., reducing pH to 6.8) but by approximately 0.42 when [HCO3-] in the bath (i.e., basolateral solution) was lowered to 5 mM.	pco2	81-85	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-3
2316714-5	1990	The results indicate that acidosis inhibits hypoxia-induced triggering of EPO formation independently of PCO2 and HCO3 levels.	pco2	105-109	erythropoietin	Mus musculus	74-77
2109496-6	1990	Even moderate CPAP induced alveolar hyperventilation with marked reduction in arterial PCO2 (PaCO2) when breathing air.	pco2	87-91	centromere protein J	Homo sapiens	14-18
35276081-3	2022	An increase in the partial pressure of carbon dioxide (PCO2) has been shown to cause connexin26 (Cx26) gap junctions to close.	pco2	55-59	gap junction protein beta 2	Homo sapiens	85-95
2106718-1	1990	We studied the relationship between contractile function and intracellular pH (pHi) in the isolated rat diaphragm when superfusate PCO2 was changed during hyperoxia or hypoxia.	pco2	131-135	glucose-6-phosphate isomerase	Rattus norvegicus	75-77
2106718-1	1990	We studied the relationship between contractile function and intracellular pH (pHi) in the isolated rat diaphragm when superfusate PCO2 was changed during hyperoxia or hypoxia.	pco2	131-135	glucose-6-phosphate isomerase	Rattus norvegicus	79-82
35276081-3	2022	An increase in the partial pressure of carbon dioxide (PCO2) has been shown to cause connexin26 (Cx26) gap junctions to close.	pco2	55-59	gap junction protein beta 2	Homo sapiens	97-101
2595242-3	1989	When pCO2 was used to alter pH, cCa2+ varied from 0.16 mmol l-1 per pH unit to 0.52 mmol l-1.	pco2	5-9	crystallin beta B2	Homo sapiens	32-36
2970232-2	1988	Base-line plasma ANF (range from 29.8 to 219 pg/ml; mean +/- SE = 87.0 +/- 14.1 pg/ml; n = 16 rabbits) was negatively correlated with base-line arterial PO2 (r = -0.759; P less than 0.01) but not with PCO2, pH, mean arterial blood pressure, central venous pressure (CVP), minute ventilation, heart rate, or type of anesthetics used.	pco2	201-205	natriuretic peptides A	Oryctolagus cuniculus	17-20
2503269-2	1989	A small but statistically significant dependence was found, averaging about 2.3% per 100 mmHg (1.7% per 10 kPa) for pO2 and 1.0% per 100 mmHg (0.75% per 10 kPa) for pCO2.	pco2	165-169	crystallin gamma F, pseudogene	Homo sapiens	116-125
3144183-3	1988	We tested this hypothesis by acutely changing systemic PCO2 in rats chronically fed ACD or ALK.	pco2	55-59	ALK receptor tyrosine kinase	Rattus norvegicus	91-94
2790155-5	1989	But after the recalculation of P50 to the standard conditions (t = 37 degrees C, pH 7.4, PCO2 = 40 Torr) it"s value was below the initial one by 4.0 +/- 0.68 Torr.	pco2	89-93	Y-box-binding protein 1	Oryctolagus cuniculus	31-34
3169488-7	1988	Increased PCO2 (10% vol/vol in the gas) in a slightly acidic milieu (mimicking mucosal ischemia) likewise acidified pHi to 6.73 +/- 0.05.	pco2	10-14	glucose-6-phosphate isomerase	Homo sapiens	116-119
2970232-4	1988	The increase in arterial pH and minute ventilation and the decrease of arterial PCO2 paralleled the changes in plasma ANF.	pco2	80-84	natriuretic peptides A	Oryctolagus cuniculus	118-121
3260620-5	1988	IL-2 therapy produced a syndrome similar to endotoxemia with the development of respiratory alkalosis (pH = 7.44 +/- .2, pCO2 = 30 +/- 2) and hypotension (mean BP, 71.3 mm Hg).	pco2	121-125	interleukin 2	Homo sapiens	0-4
3145321-15	1988	The swelling of red cells under hypoxic and/or acidotic conditions (induced by either added HCl or increased PCO2) was associated with an increase in the intracellular K+, Na+ and Cl- levels, together with an increase in the Donnan distribution ratio of Cl-, rCl.	pco2	109-113	2'-deoxynucleoside 5'-phosphate N-hydrolase 1	Rattus norvegicus	180-182
3123519-2	1988	For the same changes in external pH, changes in [HCO3] and PCO2 affected cell pH similarly ([HCO3]: pHi/pHe = 0.67, PCO2: pHi/pHe = 0.64, NS).	pco2	116-120	glucose-6-phosphate isomerase	Homo sapiens	122-125
2835077-8	1988	The effective stability constant for the binding of Gd(III) to this site of transferrin at pH 7.4 and ambient pCO2 is 6.8 X 10(6) M-1.	pco2	110-114	transferrin	Homo sapiens	76-87
3425345-6	1987	Furthermore, the ventilatory equivalent for O2 at a given work load was markedly higher in the LPP than in the control condition, while exercise-induced decreases in end-tidal PCO2 were considerably exaggerated by LPP.	pco2	176-180	LIM domain containing preferred translocation partner in lipoma	Homo sapiens	214-217
3032886-6	1987	The results suggest that correlations between Pco2 and/or pH and whole-lung ACE activity that might occur in diseased lungs do not imply causalty.	pco2	46-50	angiotensin-converting enzyme	Oryctolagus cuniculus	76-79
3662082-5	1987	Saturation ScO2, computed on-line from mass spectrometer end-tidal PO2 and PCO2, was used to manually adjust FIO2 breath by breath to obtain a rapid fall to a hypoxic plateau lasting 30-45s, followed by rapid resaturation.	pco2	75-79	synthesis of cytochrome C oxidase 2	Homo sapiens	11-15
3115132-3	1987	Due to the high arterio-venous gradient in pH and pCO2 during CPR, arterial blood gas analysis is only useful for evaluation for ventilatory efficiency and oxygenation.	pco2	50-54	cytochrome p450 oxidoreductase	Homo sapiens	62-65
2823533-0	1987	Effect of arterial pH and PCO2 on biliary HCO3- secretion in the pig.	pco2	26-30	HCO3	Sus scrofa	42-46
2823533-1	1987	The purpose of the present study was to examine the effect of changes in arterial pH and PCO2 on biliary HCO3- secretion.	pco2	89-93	HCO3	Sus scrofa	105-109
2823533-7	1987	In group I, biliary HCO3- secretion exhibited PCO2-dependent, positive straight line relationships to arterial pH.	pco2	46-50	HCO3	Sus scrofa	20-24
2823533-8	1987	An increment in biliary HCO3- secretion of 17 (11-24)% was seen during high PCO2 at pH 7.40.	pco2	76-80	HCO3	Sus scrofa	24-28
2823533-9	1987	In group II, biliary HCO3- secretion exhibited PCO2-dependent, positive curvilinear relationships to arterial pH.	pco2	47-51	HCO3	Sus scrofa	21-25
2823533-10	1987	A median increment in HCO3- secretion of 37 (20-62)% was seen during elevated PCO2 at arterial pH 7.40.	pco2	78-82	HCO3	Sus scrofa	22-26
2823533-11	1987	The linear dependence of ductular HCO3- secretion on arterial pH and the effect of elevated PCO2 on HCO3- secretion fit well with findings in other epithelia, where proton transport is thought be driven by a proton pump.	pco2	92-96	HCO3	Sus scrofa	100-104
3091840-6	1986	Specifically, there was a monotonic decrease in pHi comparable to that observed when PCO2 is increased from 5% to 10% (delta OD = -0.018 +/- 0.002 CO2; delta OD = -0.020 +/- 0.002 PYR, respectively).	pco2	85-89	glucose-6-phosphate isomerase	Homo sapiens	48-51
3567048-4	1987	Adenosine infusion at rates of 6.1 mg min-1 and above caused a significant increase in minute ventilation, principally due to an increase in tidal volume, with an associated significant fall in end-tidal Pco2.	pco2	204-208	CD59 molecule (CD59 blood group)	Homo sapiens	38-43
3017962-11	1986	When HCO3- was lowered from 46 to 10 mM at constant pCO2 (5%), pHi dropped by a DIDS-sensitive mechanism.	pco2	52-56	glucose-6-phosphate isomerase	Homo sapiens	63-66
3103248-6	1987	However, over the entire spectrum of PCO2 change, both indexes of CO2 chemosensitivity correlated strongly with the postoperative change in PCO2 (r = -0.86 for delta VE/delta PCO2 and r = -0.66 for delta P100/delta PCO2).	pco2	140-144	2'-5'-oligoadenylate synthetase 3	Homo sapiens	204-214
3802459-6	1987	At any given [HCO3]p, pK1" values were higher at high than at low values of pco2.	pco2	76-80	pyruvate kinase L/R	Homo sapiens	22-25
3096150-4	1986	When PTH was infused in TPTX rats to maintain constant the plasma PTH level, subsequent phosphate infusion increased [Pi]u and elevated U-B PCO2 for any value of [HCO3]u.	pco2	140-144	parathyroid hormone	Rattus norvegicus	5-8
3081349-3	1986	The CSF pressure in control dogs increased moderately in response to PCO2; in dogs with hydrocephalus, an increase in PCO2 produced a pronounced increase in CSF pressure accompanied by a simultaneous decrease in cerebral perfusion pressure.	pco2	69-73	colony stimulating factor 2	Canis lupus familiaris	4-7
3081349-3	1986	The CSF pressure in control dogs increased moderately in response to PCO2; in dogs with hydrocephalus, an increase in PCO2 produced a pronounced increase in CSF pressure accompanied by a simultaneous decrease in cerebral perfusion pressure.	pco2	118-122	colony stimulating factor 2	Canis lupus familiaris	4-7
3081349-3	1986	The CSF pressure in control dogs increased moderately in response to PCO2; in dogs with hydrocephalus, an increase in PCO2 produced a pronounced increase in CSF pressure accompanied by a simultaneous decrease in cerebral perfusion pressure.	pco2	118-122	colony stimulating factor 2	Canis lupus familiaris	157-160
3001738-8	1986	Reducing [HCO3-]o from 25 to 5 mM at constant pCO2 (lowering pHo from 7.4 to 6.7) caused pHi to reversibly fall by approximately equal to 0.2.	pco2	46-50	vasoactive intestinal peptide	Sus scrofa	89-92
3599550-2	1986	Reductions of the blood P50 (pH 7.40, PCO2 40 Torr, 37 degrees C) and 2,3-diphosphoglycerate (DPG) during storage was much slower than in human blood.	pco2	38-42	nuclear factor kappa B subunit 1	Homo sapiens	24-27
3931976-1	1985	During experimental CPR, a marked venoarterial gradient in PCO2 has been reported.	pco2	59-63	cytochrome p450 oxidoreductase	Homo sapiens	20-23
3925792-11	1985	These findings suggest that the systemic acid-base disorders cause changes in colonic mucosal pHi and [HCO3]i as a consequence of altered arterial PCO2 and HCO3 concentration.	pco2	147-151	glucose-6-phosphate isomerase	Rattus norvegicus	94-97
3928721-3	1985	Therefore, we set up a procedure which allows for measurement of the pH of GCF samples from single inflamed sites at controlled PCO2.	pco2	128-132	GC-rich sequence DNA-binding factor 2	Homo sapiens	75-78
3983482-5	1985	Changes in CSF PCO2 and pH were made by infusing 100% CO2 or an acid buffer into the CSF.	pco2	15-19	granulocyte-macrophage colony-stimulating factor	Felis catus	11-14
4010872-10	1985	Oral nimodipine therapy resulted in a significant (14%) increased of the CBF (taking account of the arterial pCO2), the improvement of blood flow being even more pronounced in the hypoperfused regions.	pco2	109-113	CCAAT/enhancer binding protein zeta	Rattus norvegicus	73-76
3925792-4	1985	When animals in all groups were considered, there were strong correlations between mucosal pHi and both arterial PCO2 (r = -0.76) and pH (r = 0.82) and between mucosal [HCO3]i and both arterial PCO2 (r = 0.98) and HCO3 concentration (r = 0.77).	pco2	113-117	glucose-6-phosphate isomerase	Rattus norvegicus	91-94
3925792-4	1985	When animals in all groups were considered, there were strong correlations between mucosal pHi and both arterial PCO2 (r = -0.76) and pH (r = 0.82) and between mucosal [HCO3]i and both arterial PCO2 (r = 0.98) and HCO3 concentration (r = 0.77).	pco2	113-117	glucose-6-phosphate isomerase	Rattus norvegicus	91-93
3925792-4	1985	When animals in all groups were considered, there were strong correlations between mucosal pHi and both arterial PCO2 (r = -0.76) and pH (r = 0.82) and between mucosal [HCO3]i and both arterial PCO2 (r = 0.98) and HCO3 concentration (r = 0.77).	pco2	194-198	glucose-6-phosphate isomerase	Rattus norvegicus	91-93
6419623-6	1983	With exposure to increasing extracellular PCO2, there is a polynomial decrease in pHi.	pco2	42-46	glucose-6-phosphate isomerase	Homo sapiens	82-85
6469779-7	1984	Arterial PCO2 increased sharply at the time when dPdi decreased.	pco2	9-13	Protein disulfide isomerase	Drosophila melanogaster	49-53
6442511-0	1984	Tissue pO2 and pCO2 in the gastrointestinal tract and liver during intravenous vasopressin infusion.	pco2	15-19	vasopressin	Sus scrofa	79-90
6442511-7	1984	Vasopressin infusion caused significant fall in the tissue pO2 and increase in the pCO2 throughout the gastrointestinal tract.	pco2	83-87	vasopressin	Sus scrofa	0-11
6794946-5	1981	Empirical equations and a nomogram were derived, which allow the calculation of p50 from known values of pCO2, pH, and [2,3-DPG]/[Hb4] molar ratio with a SD of 97 and 114 Pa (0.73 and 0.86 mmHg), respectively.	pco2	105-109	nuclear factor kappa B subunit 1	Homo sapiens	80-83
6848245-3	1983	Assuming that the effect of pco2 on the p50 value is the same at 19, 30, and 43 degrees C as at 37 degrees C, one can use the reported coefficients to calculate the p50 value for normal human blood under conditions of temperature, pH, pco2, and 2,3-diphosphoglycerate concentrations prevailing under physiological and pathological conditions.	pco2	28-32	nuclear factor kappa B subunit 1	Homo sapiens	40-43
6848245-3	1983	Assuming that the effect of pco2 on the p50 value is the same at 19, 30, and 43 degrees C as at 37 degrees C, one can use the reported coefficients to calculate the p50 value for normal human blood under conditions of temperature, pH, pco2, and 2,3-diphosphoglycerate concentrations prevailing under physiological and pathological conditions.	pco2	28-32	nuclear factor kappa B subunit 1	Homo sapiens	165-168
6848245-3	1983	Assuming that the effect of pco2 on the p50 value is the same at 19, 30, and 43 degrees C as at 37 degrees C, one can use the reported coefficients to calculate the p50 value for normal human blood under conditions of temperature, pH, pco2, and 2,3-diphosphoglycerate concentrations prevailing under physiological and pathological conditions.	pco2	235-239	nuclear factor kappa B subunit 1	Homo sapiens	165-168
6816922-6	1982	Over the range studied, hepatic pHi was negatively and linearly related to the logarithm of perfusate PCO2.	pco2	102-106	glucose-6-phosphate isomerase	Rattus norvegicus	32-35
7319892-6	1981	Increasing PCO2 at constant perfusate HCO-3 resulted in changes in pHi and cell HCO-3 (HCO-3i) that were similar in both Cl--free and Cl--containing hearts.	pco2	11-15	glucose-6-phosphate isomerase	Homo sapiens	67-70
6816650-1	1982	The pO2 at which haemoglobin is half-saturated with oxygen (p50) was determined at fixed pCO2 (45 mmHg) and without altering the resulting pH and the level of organic phosphates in heparinized whole blood samples from 26 diabetic patients and 24 normal subjects of both sexes.	pco2	89-93	nuclear factor kappa B subunit 1	Homo sapiens	60-63
6813948-2	1982	The influence of pH on P50 expressed as the H+ factor (delta log P50/delta pH)PCO2 was measured under conditions of varying PCO2, temperature and concentration of 2,3-diphosphoglycerate (2,3-DPG), resulting in a set of data expressing second-order inter-ligand interactions.	pco2	78-82	granzyme A	Homo sapiens	44-53
6813948-2	1982	The influence of pH on P50 expressed as the H+ factor (delta log P50/delta pH)PCO2 was measured under conditions of varying PCO2, temperature and concentration of 2,3-diphosphoglycerate (2,3-DPG), resulting in a set of data expressing second-order inter-ligand interactions.	pco2	78-82	nuclear factor kappa B subunit 1	Homo sapiens	65-74
6813948-3	1982	The H+ factor appeared to be only slightly dependent on PCO2.	pco2	56-60	granzyme A	Homo sapiens	4-13
6813948-4	1982	Similarly, the CO2 factor (delta log P50/delta log PCO2)pH shows only a minor dependence on pH.	pco2	51-55	nuclear factor kappa B subunit 1	Homo sapiens	37-46
6795980-3	1981	In all subjects studied, the increase in EMGdi, quantified as the average rate of rise of inspiratory moving average activity, and transdiaphragmatic pressure (Pdi) were linearly related to the increase in end-tidal PCO2 during CO2 rebreathing (range of r, 0.88 to 0.99 and 0.85 to 0.99, respectively).	pco2	216-220	peptidyl arginine deiminase 1	Homo sapiens	160-163
391160-4	1979	Discontinuation of CPAP at 6 cmH2O resulted in a mean change in PO2 from 66 to 64 mmHg (8.8 to 8.5 kPa) and a mean change in PCO2 from 41 to 40 mmHg (5.4 to 5.3 kPa).	pco2	125-129	centromere protein J	Homo sapiens	19-23
6782233-7	1980	Elevation of blood pCO2 also attenuates the hypophosphatemic response to calcitonin.	pco2	19-23	calcitonin-related polypeptide alpha	Rattus norvegicus	73-83
6800006-4	1981	pHi exceeded pHe if either PCO2 and/or the concentration of lactic acid was raised above a critical level.	pco2	27-31	glucose-6-phosphate isomerase	Rattus norvegicus	0-3
7245731-5	1981	Reproducibility of the results as regards time, presented by variation coefficient (VC), followed up for a period of 9 months by the control materials Acidbasol with ABL 2 apparatus proved to be very good in the three ranges tested for pH and pCO2.	pco2	243-247	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	166-171
441571-0	1979	Role of PCO2 as determinant of CSF [HCO-3] in metabolic acidosis.	pco2	8-12	colony stimulating factor 2	Canis lupus familiaris	31-34
441571-6	1979	There was a gradual drop in PaCO2 accompanied by a similar drop in CSF PCO2 of 14.5 torr.	pco2	71-75	colony stimulating factor 2	Canis lupus familiaris	67-70
441571-7	1979	CSF [HCO-3] fell significantly by 6.1 meq/L at 6 hours and in parallel with the fall in CSF PCO2.	pco2	92-96	colony stimulating factor 2	Canis lupus familiaris	0-3
441571-7	1979	CSF [HCO-3] fell significantly by 6.1 meq/L at 6 hours and in parallel with the fall in CSF PCO2.	pco2	92-96	colony stimulating factor 2	Canis lupus familiaris	88-91
441571-9	1979	CSF PCO2 followed PaCO.	pco2	4-8	colony stimulating factor 2	Canis lupus familiaris	0-3
441571-12	1979	Therefore, in metabolic acidosis the rate of the fall in cisternal bicarbonate appears to be a function of the rate of fall in CSF PCO2.	pco2	131-135	colony stimulating factor 2	Canis lupus familiaris	127-130
441571-13	1979	It is speculated that the coupling of CSF [HCO-3] reduction in metabolic acidosis to CSF PCO2 fall is primarily for the benefit of CNS H+ homeostasis.	pco2	89-93	colony stimulating factor 2	Canis lupus familiaris	38-41
441571-13	1979	It is speculated that the coupling of CSF [HCO-3] reduction in metabolic acidosis to CSF PCO2 fall is primarily for the benefit of CNS H+ homeostasis.	pco2	89-93	colony stimulating factor 2	Canis lupus familiaris	85-88
28197-4	1978	In general, pHi and lactate uptake are inversely related to PCO2, and pHi and lactate uptake are directly related to each other, but the quantitative aspects and significance of these relationships vary with the availability of lactate.	pco2	60-64	glucose-6-phosphate isomerase	Rattus norvegicus	12-15
32935-1	1978	The two equilibrium constants that define the extent of carbamino adduct formation with amines for all values of pH and PCO2 are determined for the alpha-amino groups of the peptide hormones angiotensin II(AII) and bradykinin (BK) by nuclear magnetic resonance techniques.	pco2	120-124	NLR family pyrin domain containing 3	Homo sapiens	191-210
32935-1	1978	The two equilibrium constants that define the extent of carbamino adduct formation with amines for all values of pH and PCO2 are determined for the alpha-amino groups of the peptide hormones angiotensin II(AII) and bradykinin (BK) by nuclear magnetic resonance techniques.	pco2	120-124	kininogen 1	Homo sapiens	215-225
33357-2	1979	The most striking alterations of the parameters investigated were found in infants treated with nasal-CPAP and controlled ventilation where especially a decrease of pH and increase of pCO2 was observed.	pco2	184-188	centromere protein J	Homo sapiens	102-106
28198-6	1978	In general there were significant positive correlations between intracellular pH (pHi) and hepatocyte phosphoenolpyruvate, 2-phosphoglycerate and 3-phosphoglycerate concentrations, and negative correlations between pHi and lactate and pyruvate concentrations; there were usually significant correlations in the opposite  sense between these metabolites and log PCO2.	pco2	361-365	glucose-6-phosphate isomerase	Rattus norvegicus	82-85
4176-7	1976	A simple device for maintaining PRP pH constant by control of the ambient pCO2 was designed and found effective in keeping both pH and quantitative ristocetin aggregation constant over a prolonged period of time.	pco2	74-78	complement component 4 binding protein alpha	Homo sapiens	32-35
24868-2	1977	Under physiological conditions (41 C, pH 7.5, PCO2 approximately 35 Torr) the oxygen half saturation pressure P50 are 50 Torr for the chickens, 38 Torr for the pigeon, 43 Torr for the Japanese quail and 44 Torr for the sparrow.	pco2	46-50	dynactin subunit 2	Gallus gallus	110-113
15306-2	1977	We observed cerebral blood flow-related steady-state differences in PCO2 between CSF and arterial venous blood from the brain.	pco2	68-72	colony stimulating factor 2	Canis lupus familiaris	81-84
15306-3	1977	The steady-state values of CSF-blood PCO2 differences and blood H+ activity were intermediate to those observed by us previously during uncompensated acidosis and alkalosis (J. Appl.	pco2	37-41	colony stimulating factor 2	Canis lupus familiaris	27-30
14366-3	1976	HC1 infusion, CSF [HCO3] increased 8.5 mM/L after 2 hours of hypercapnia (delta PCO2 40) in the rats with intraventricular "mock" CSF injections, and only 6 mM/L in the animals with acetazolamide injections.	pco2	80-84	Hypercalciuria QTL 1	Rattus norvegicus	0-3
945553-2	1976	The tip diameter of the electrode is only a few microns, the tip is specially designed for measuring PCO2 in small tissue compartements.	pco2	101-105	TOR signaling pathway regulator	Homo sapiens	4-7
945553-2	1976	The tip diameter of the electrode is only a few microns, the tip is specially designed for measuring PCO2 in small tissue compartements.	pco2	101-105	TOR signaling pathway regulator	Homo sapiens	61-64
29457-0	1978	Interaction between PCO2 and plasma [HCO-3] in regulation of CSF [HCO-3] in respiratory alkalosis and metabolic acidosis.	pco2	20-24	colony stimulating factor 2	Homo sapiens	61-64
21153-0	1977	Effects of hypocapnia PCO2 gradients between CSF and cerebral capillary blood.	pco2	22-26	colony stimulating factor 2	Homo sapiens	45-48
16010-3	1977	Similar measurements were done on Hb A and the fraction of oxygen-linked carbamate calculated from the effect of pCO2 (at constant pH) on the oxygen half-saturation pressure (p50).	pco2	113-117	nuclear factor kappa B subunit 1	Homo sapiens	175-178
8997-5	1976	When CSF [HCO3-] is shown as a function of CSF PCO2 the data of K-depleted rats are no longer displaced when compared to controls but still have a significantly greater slope (1.21 +/- 0.23 vs. 0.89 +/- 0.08).	pco2	47-51	colony stimulating factor 2	Rattus norvegicus	43-46
8997-7	1976	Analysis of our data and observations from the literature in conditions of mixed acid-base disturbances suggest that CSF [HCO3-] is determined by a) CSF PCO2 and b) the level of arterial [HCO3-] when the latter is greater than the normal CSF [HCO3-].	pco2	153-157	colony stimulating factor 2	Rattus norvegicus	117-120
8997-7	1976	Analysis of our data and observations from the literature in conditions of mixed acid-base disturbances suggest that CSF [HCO3-] is determined by a) CSF PCO2 and b) the level of arterial [HCO3-] when the latter is greater than the normal CSF [HCO3-].	pco2	153-157	colony stimulating factor 2	Rattus norvegicus	149-152
8997-7	1976	Analysis of our data and observations from the literature in conditions of mixed acid-base disturbances suggest that CSF [HCO3-] is determined by a) CSF PCO2 and b) the level of arterial [HCO3-] when the latter is greater than the normal CSF [HCO3-].	pco2	153-157	colony stimulating factor 2	Rattus norvegicus	149-152
13893-4	1976	When haemoglobin passed from the reduced to the completely oxygenated state, a significant decrease of both pHe and pHi was observed for a given PCO2 (respectively about 0.05 and 0.08 pH unit), and of pHi for a given pHe (about 0.04 pH unit).	pco2	145-149	glucose-6-phosphate isomerase	Homo sapiens	116-119
943273-12	1976	The resting arterial PCO2 (Pa,CO2) ranged from 5-0 to 5-8 kPa.	pco2	21-25	complement C2	Homo sapiens	27-33
911-3	1975	When pHe was varied by altering PCO2, the slope of the line relating pHi to the extracellular pH (pHe) was greater (P less than 0.05--0.001) than that obtained during metabolic changes of pHe in right and left ventricles, atria, diaphragm, and quadriceps.	pco2	32-36	glucose-6-phosphate isomerase	Oryctolagus cuniculus	69-72
5765-6	1976	This dependence of changes in CSF on plasma [HCO3] required a concurrent decrease in CSF PCO2, but was largely independent of variations in plasma pH.	pco2	89-93	colony stimulating factor 2	Homo sapiens	30-33
5765-6	1976	This dependence of changes in CSF on plasma [HCO3] required a concurrent decrease in CSF PCO2, but was largely independent of variations in plasma pH.	pco2	89-93	colony stimulating factor 2	Homo sapiens	85-88
4084-1	1976	The measurement of pH, PO2, PCO2 and SO2 in a single venous blood sample can be used to determine the P50 at standard or at in vivo conditions.	pco2	28-32	nuclear factor kappa B subunit 1	Homo sapiens	102-105
1273510-3	1976	The direct effects of changes in pO2, pCO2, pH and various cell nutrients on cells producing erythropoietin is now possible.	pco2	38-42	erythropoietin	Ovis aries	93-107
4950-2	1975	The different values of PCO2, PO2, pH and alcaline reserve measured on samples of CSF in comatose patients prove the central acidosis related to metabolic and vascular disorders in the damaged areas.	pco2	24-28	colony stimulating factor 2	Homo sapiens	82-85
241651-3	1975	Under the intragastric instillation of 100 ml/h 0.1 N HCl the rise of gastrin concentration in response to CO2 rebreathing (pCO2 68 torr, pH 7.20) was not significant.	pco2	124-128	gastrin	Homo sapiens	70-77
31473201-8	2019	S100B protein concentration correlate directly with pCO2 levels (Rho: 0.286, p = .0321) and lactate concentration (Rho: 0.278, p = .0315); and indirectly with pH (Rho: -0.332, p = .01).	pco2	52-56	S100 calcium binding protein B	Homo sapiens	0-5
4440759-0	1974	PCO2 gradients between blood and CSF in the rat during alterations of acid-base balance.	pco2	0-4	colony stimulating factor 2	Rattus norvegicus	33-36
5980541-0	1966	Influence of pH, pCO2 and pO2 on erythrocytic adsorption of fibrinogen.	pco2	17-21	fibrinogen beta chain	Homo sapiens	60-70
31426219-0	2019	Sea surface pCO2 in an urbanized coastal system (Jiaozhou Bay, China) during summer.	pco2	12-16	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
29600897-2	2018	We hypothesized that the coronary vascular response to Po2 and Pco2 would be attenuated in healthy men when [Formula: see text] was attenuated with beta1-adrenergic receptor blockade.	pco2	63-67	adrenoceptor beta 1	Homo sapiens	148-173
30777401-4	2019	The hemogasanalysis and spectrophotometric test on blood for Methemoglobin (MetHb), Carboxyhemoglobin (HbCO) and Sulfhemoglobin (SHb) showed pCO2, SHb and MetHb above the physiological levels.	pco2	141-145	hemoglobin subunit gamma 2	Homo sapiens	61-74
30777401-4	2019	The hemogasanalysis and spectrophotometric test on blood for Methemoglobin (MetHb), Carboxyhemoglobin (HbCO) and Sulfhemoglobin (SHb) showed pCO2, SHb and MetHb above the physiological levels.	pco2	141-145	hemoglobin subunit gamma 2	Homo sapiens	155-160
29209598-4	2017	We aimed to determine if a higher PCO2 target range results in less lung injury compared to the control target range and possibly reduces pro-inflammatory cytokines and acid sphingomyelinase (ASM) in tracheal aspirates (TA), which has not been addressed before.	pco2	34-38	sphingomyelin phosphodiesterase 1	Homo sapiens	169-190
29551475-13	2018	Studies to evaluate PCO2 level to discriminate HFNC versus CPAP indication could be useful.	pco2	20-24	centromere protein J	Homo sapiens	59-63
29066557-11	2017	In sum, Nmb is a selective marker of the RTN in rodents; Nmb-low neurons, the vast majority, are central respiratory chemoreceptors, whereas Nmb-high neurons likely have other functions.SIGNIFICANCE STATEMENT Central respiratory chemoreceptors regulate arterial PCO2 by adjusting lung ventilation.	pco2	262-266	neuromedin B	Mus musculus	8-11
29575641-6	2018	Patients who died were more likely to have underlying congenital heart disease; have a higher increase in the concentration of carbon dioxide in the blood (pCO2 ) with a corresponding greater mean percentage decrease in pH and percentage rise in NT-pro BNP during PH exacerbations; more likely to have been on medications for pulmonary hypertension; and have a higher RVSP/SBP (%) ratio and S/D ratio.	pco2	156-160	natriuretic peptide B	Homo sapiens	253-256
29575641-6	2018	Patients who died were more likely to have underlying congenital heart disease; have a higher increase in the concentration of carbon dioxide in the blood (pCO2 ) with a corresponding greater mean percentage decrease in pH and percentage rise in NT-pro BNP during PH exacerbations; more likely to have been on medications for pulmonary hypertension; and have a higher RVSP/SBP (%) ratio and S/D ratio.	pco2	156-160	selenium binding protein 1	Homo sapiens	373-376
29411336-4	2018	Risk factors for CSB are older age, male gender, high BMI, atrial fibrillation and hypocapnia.The pathophysiology of CSB has been explained by the loop gain theory, where a controller (the respiratory center) and a plant (the lungs) are operating in a reciprocal relationship (negative feedback) to regulate a key parameter (partial pressure of carbon dioxide (pCO2)).	pco2	361-365	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	17-20
29411336-4	2018	Risk factors for CSB are older age, male gender, high BMI, atrial fibrillation and hypocapnia.The pathophysiology of CSB has been explained by the loop gain theory, where a controller (the respiratory center) and a plant (the lungs) are operating in a reciprocal relationship (negative feedback) to regulate a key parameter (partial pressure of carbon dioxide (pCO2)).	pco2	361-365	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	117-120
28966145-3	2018	This "CO2 chemoreflex" has been interpreted to dominate control of resting arterial PCO2/pH (PaCO2/pHa) by monitoring PaCO2/pHa and altering ventilation through negative feedback.	pco2	84-88	lamin B receptor	Homo sapiens	93-102
28966145-3	2018	This "CO2 chemoreflex" has been interpreted to dominate control of resting arterial PCO2/pH (PaCO2/pHa) by monitoring PaCO2/pHa and altering ventilation through negative feedback.	pco2	84-88	lamin B receptor	Homo sapiens	118-127
29209598-4	2017	We aimed to determine if a higher PCO2 target range results in less lung injury compared to the control target range and possibly reduces pro-inflammatory cytokines and acid sphingomyelinase (ASM) in tracheal aspirates (TA), which has not been addressed before.	pco2	34-38	sphingomyelin phosphodiesterase 1	Homo sapiens	192-195
25297052-7	2015	PolyHb-SOD-CAT-CA reduced tissue pCO2 from 98 +- 4.5 mmHg to 68.6 +- 3 mmHg.	pco2	33-37	catalase	Rattus norvegicus	11-14
28319329-10	2017	NBCn1 is equivalently inhibited when pCO2 is raised or [HCO3-]o decreased.	pco2	37-41	solute carrier family 4, sodium bicarbonate cotransporter, member 7	Mus musculus	0-5
27122565-9	2016	pCO2 is the best explanatory variable in the Arabian Sea, but explains little of the variance in diversity in the eastern Pacific Ocean.	pco2	0-4	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	53-56
25609423-2	2015	Presently, a drastic discrepancy exists between the answers to these two questions obtained from mass-spectrometric (18)O-exchange measurements (Chol reduces Pco2 100-fold, AQP1 increases Pco2 10-fold) vs. from stopped-flow approaches observing CO2 uptake (no effects of either Chol or AQP1).	pco2	188-192	aquaporin 1 (Colton blood group)	Homo sapiens	173-177
25609423-3	2015	A novel theory of CO2 uptake by vesicles predicts that in a stopped-flow apparatus this fast process can only be resolved temporally and interpreted quantitatively, if 1) a very low CO2 partial pressure (pCO2) is used (e.g., 18 mmHg), and 2) intravesicular carbonic anhydrase (CA) activity is precisely known.	pco2	204-208	ATP synthase inhibitory factor subunit 1	Homo sapiens	165-169
25609423-4	2015	With these prerequisites fulfilled, we find by stopped-flow that 1) Chol-containing vesicles possess a Pco2 = 0.01cm/s, and Chol-free vesicles exhibit ~1 cm/s, and 2) the Pco2 of 0.01 cm/s is increased >= 10-fold by AQP1.	pco2	171-175	aquaporin 1 (Colton blood group)	Homo sapiens	219-223
25609423-6	2015	We confirm that biologic membranes have an intrinsically low Pco2 that can be raised when functionally necessary by incorporating protein-gas channels such as AQP1.	pco2	61-65	aquaporin 1 (Colton blood group)	Homo sapiens	159-163
28619629-0	2017	Scales and drivers of seasonal pCO2 dynamics and net ecosystem exchange along the coastal waters of southeastern Arabian Sea.	pco2	31-35	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	121-124
27980124-4	2017	Conversely, arterial PCO2  can also be elevated by lowering ventilation relative to metabolism (i.e. reducing the air convection requirement, ACR).	pco2	21-25	acrosin	Homo sapiens	142-145
27701904-8	2016	Weak correlation was found regarding pCO2 and MEA as well as regarding glucose concentration and MEA.	pco2	37-41	male-enhanced antigen 1	Homo sapiens	46-49
27657726-5	2016	In WT mice, neocortical application of the EP1 receptor antagonist SC-51089 attenuated the increase in CBF elicited by systemic hypercapnia (pCO2 = 50-60 mmHg).	pco2	141-145	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	43-46
27882073-11	2016	The posttreatment PCO2 was significantly lower in ALP-CPR group than in STD-CPR group (52.33 versus 58.81, P = 0.009).	pco2	18-22	cytochrome p450 oxidoreductase	Homo sapiens	54-57
27882073-11	2016	The posttreatment PCO2 was significantly lower in ALP-CPR group than in STD-CPR group (52.33 versus 58.81, P = 0.009).	pco2	18-22	cytochrome p450 oxidoreductase	Homo sapiens	76-79
26442471-4	2015	This study was conducted to determine whether the elevated partial pressure of CO2 (pCO2) would have an effect on growth, otolith (ear bone) condition, survival, or the skeleton of juvenile scup, Stenotomus chrysops, a species that supports both important commercial and recreational fisheries.	pco2	84-88	complement C2	Homo sapiens	79-82
25982047-10	2015	Myeloperoxidase levels were found to be 8-fold higher in lungs of ACS rats relative to control (P < 0.05), as well as statistically significant increase in the pCO2 and decrease in pH of ACS rats.	pco2	163-167	myeloperoxidase	Rattus norvegicus	0-15
25559488-3	2015	Analysis of metabolome and proteome revealed that elevated pCO2 could affect energy metabolism in oyster C. gigas, marked by differentially altered ATP, succinate, MDH, PEPCK and ALDH levels.	pco2	59-63	Phosphoenolpyruvate carboxykinase [GTP]-like	Crassostrea gigas	169-174
25559488-4	2015	Moreover, the up-regulated calponin-2, tropomyosins and myosin light chains indicated that elevated pCO2 probably caused disturbances in cytoskeleton structure in mantle tissue of oyster C. gigas.	pco2	100-104	calponin-2	Crassostrea gigas	27-37
25898645-2	2015	The results were listed as follows, when Xiaolangdi Reservoir operated normally, pCO2 in surface water of Xiaolangdi station and Huayuankou station varied from 82 to 195 Pa and from 99 to 228 Pa, moreover, pCO2 in surface water from July to September were distinctly higher than those in other months; meanwhile, pCO, in surface water from Huayuankou station were higher than that from Xiaolangdi station.	pco2	206-210	PCOS1	Homo sapiens	81-84
25219137-2	2014	Additionally the effect of pH and pCO2 on the number of cord blood CD34+ cells and their vitality was analyzed.	pco2	34-38	CD34 molecule	Homo sapiens	67-71
25219137-13	2014	However when pCO2 was > or = 38 mmHg, the number of CD34+ ranged between 0.1-0.2.	pco2	13-17	CD34 molecule	Homo sapiens	55-59
24706552-6	2014	These findings suggest that, while CA is not limiting for C4 photosynthesis in maize at current pCO2, it likely maintains high rates of photosynthesis when CO2 availability is reduced.	pco2	96-100	carbonic anhydrase	Zea mays	35-37
25059669-9	2014	In cancer cells with high CAi activity, extracellular pCO2 fluctuations evoked faster and larger pHi oscillations.	pco2	54-58	carbonic anhydrase 1	Homo sapiens	26-29
25059669-11	2014	In contrast, the pHi of cells with low CAi activity was less responsive to pCO2 fluctuations.	pco2	75-79	carbonic anhydrase 1	Homo sapiens	39-42
25059669-13	2014	Thus, CAi activity determines the coupling between pCO2 (a function of tumor perfusion) and pHi (a potent modulator of cancer cell physiology).	pco2	51-55	carbonic anhydrase 1	Homo sapiens	6-9
24941307-11	2014	Simultaneously, the efficiency of the protein-degrading enzyme leucine aminopeptidase increased with decreasing pH resulting in up to three times higher values in the highest pCO2/lowest pH mesocosm compared to the controls.	pco2	175-179	carboxypeptidase Q	Homo sapiens	71-85