PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
208537-0	1978	Superinduction of ornithine decarboxylase by actinomycin D and cordycepin.	cordycepin	63-73	ornithine decarboxylase 1	Homo sapiens	18-41
1086769-5	1976	The in vitro increase in G6PD activity is inhibited by the addition of either actinomycin D (5 mug/ml), cycloheximide (5 mug/ml), or cordycepin (150 mug/ml), or by the intrauterine injection of actinomycin D (10 mug/rat).	cordycepin	133-143	glucose-6-phosphate dehydrogenase	Rattus norvegicus	25-29
16660163-4	1977	The increase in the root tip is sensitive to cordycepin, 6-methylpurine, and cycloheximide, which indicates that both RNA and protein synthesis are involved in the formation of asparagine synthetase in the root tip sections.	cordycepin	45-55	LOC100856906	Zea mays	177-198
24420020-2	1977	The increases in PAL and CA4H activity can be inhibited by actinomycin-D, cordycepin and cycloheximide.	cordycepin	74-84	phenylalanine ammonia-lyase	Solanum tuberosum	17-20
24420020-2	1977	The increases in PAL and CA4H activity can be inhibited by actinomycin-D, cordycepin and cycloheximide.	cordycepin	74-84	trans-cinnamate 4-monooxygenase	Solanum tuberosum	25-29
240862-7	1975	These data suggest that cordycepin inhibits TAT synthesis in preinduced cells by its inhibition of protein synthesis, and this inhibitory effect of cordycepin is blocked by actinomycin-D.	cordycepin	24-34	tyrosine aminotransferase	Rattus norvegicus	44-47
988022-16	1976	The presence of camptothecin, or cordycepin, or cycloheximide in the incubation medium completely blocks the increase in number of 125I-insulin-binding sites resulting from serum starvation.	cordycepin	33-43	insulin	Gallus gallus	136-143
13756769-0	1961	Effect of cordycepin on the incorporation of P32-orthophosphate into the nucleic acids of ascites tumor cells in vitro.	cordycepin	10-20	inhibitor of growth family member 2	Homo sapiens	45-48
240862-1	1975	The effects of actinomycin-D and 3"-deoxyadenosine (cordycepin) on the steroid-mediated induction of tyrosine aminotransferase (TAT) synthesis have been reexamined in view of recent reports that the primary inhibitory action of these compounds may affect synthesis of proteins as well as RNA.	cordycepin	33-50	tyrosine aminotransferase	Rattus norvegicus	101-126
240862-1	1975	The effects of actinomycin-D and 3"-deoxyadenosine (cordycepin) on the steroid-mediated induction of tyrosine aminotransferase (TAT) synthesis have been reexamined in view of recent reports that the primary inhibitory action of these compounds may affect synthesis of proteins as well as RNA.	cordycepin	33-50	tyrosine aminotransferase	Rattus norvegicus	128-131
240862-1	1975	The effects of actinomycin-D and 3"-deoxyadenosine (cordycepin) on the steroid-mediated induction of tyrosine aminotransferase (TAT) synthesis have been reexamined in view of recent reports that the primary inhibitory action of these compounds may affect synthesis of proteins as well as RNA.	cordycepin	52-62	tyrosine aminotransferase	Rattus norvegicus	101-126
240862-1	1975	The effects of actinomycin-D and 3"-deoxyadenosine (cordycepin) on the steroid-mediated induction of tyrosine aminotransferase (TAT) synthesis have been reexamined in view of recent reports that the primary inhibitory action of these compounds may affect synthesis of proteins as well as RNA.	cordycepin	52-62	tyrosine aminotransferase	Rattus norvegicus	128-131
236835-4	1975	The effects of cordycepin (3"-deoxyadenosine) on the metabolism of TAT and its mRNA are also complex, but differ in several respects from those of AMD.	cordycepin	15-25	tyrosine aminotransferase	Rattus norvegicus	67-70
236835-4	1975	The effects of cordycepin (3"-deoxyadenosine) on the metabolism of TAT and its mRNA are also complex, but differ in several respects from those of AMD.	cordycepin	27-44	tyrosine aminotransferase	Rattus norvegicus	67-70
33549657-0	2021	Anti-inflammatory and neuroprotective effects of natural cordycepin in rotenone-induced PD models through inhibiting Drp1-mediated mitochondrial fission.	cordycepin	57-67	collapsin response mediator protein 1	Rattus norvegicus	117-121
33549657-7	2021	More importantly, cordycepin administration inhibited the expression of NLRP3 inflammasome components and the release of pro-inflammatory cytokine in rotenone-induced rats and cultured neuronal PC12 cells.	cordycepin	18-28	NLR family, pyrin domain containing 3	Rattus norvegicus	72-77
33549657-9	2021	Collectively, the present study provides evidence that cordycepin exerts neuroprotective effects partially through preventing neural NLRP3 inflammasome activation induced by Drp1-dependent mitochondrial fragmentation in rotenone-injected PD models.	cordycepin	55-65	NLR family, pyrin domain containing 3	Rattus norvegicus	133-138
33549657-9	2021	Collectively, the present study provides evidence that cordycepin exerts neuroprotective effects partially through preventing neural NLRP3 inflammasome activation induced by Drp1-dependent mitochondrial fragmentation in rotenone-injected PD models.	cordycepin	55-65	collapsin response mediator protein 1	Rattus norvegicus	174-178
33948356-8	2021	The administration of naringin and pentostatin, inhibitors for adenosine deaminase (ADA), enzyme responsible for cordycepin degradation, did not show a synergistic effect in MPNST cells treated with cordycepin.	cordycepin	113-123	adenosine deaminase	Homo sapiens	84-87
32163051-3	2020	Cordycepin-induced apoptosis led to increased PUMA, CYTO-C, FAS, DR4/5, and cleaved caspase-3; and decreased BCL-2, XIAP and PDGFR-alpha.	cordycepin	0-10	BCL2 binding component 3	Homo sapiens	46-50
33607106-6	2021	The results showed that cordycepin reduced PS amplitude in hippocampal CA1 with a concentration-dependent relationship, and high frequency stimulation (HFS) failed to induce LTP when cordycepin was intrahippocampally administrated but improved LTP magnitude when cordycepin was pre-treated.	cordycepin	24-34	carbonic anhydrase 1	Rattus norvegicus	71-74
33172093-0	2020	Anti-Cancer Effect of Cordycepin on FGF9-Induced Testicular Tumorigenesis.	cordycepin	22-32	fibroblast growth factor 9	Mus musculus	36-40
33172093-8	2020	In summary, cordycepin inhibited FGF9-induced testicular tumor growth by suppressing the ERK1/2, Rb/E2F1, cell cycle pathways, and the expressions of FGFR1-4 proteins, suggesting that cordycepin can be used as a novel anticancer drug for testicular cancers.	cordycepin	12-22	fibroblast growth factor 9 S homeolog	Xenopus laevis	33-37
33172093-8	2020	In summary, cordycepin inhibited FGF9-induced testicular tumor growth by suppressing the ERK1/2, Rb/E2F1, cell cycle pathways, and the expressions of FGFR1-4 proteins, suggesting that cordycepin can be used as a novel anticancer drug for testicular cancers.	cordycepin	12-22	mitogen-activated protein kinase 1 S homeolog	Xenopus laevis	89-95
33172093-8	2020	In summary, cordycepin inhibited FGF9-induced testicular tumor growth by suppressing the ERK1/2, Rb/E2F1, cell cycle pathways, and the expressions of FGFR1-4 proteins, suggesting that cordycepin can be used as a novel anticancer drug for testicular cancers.	cordycepin	12-22	E2F transcription factor 1 L homeolog	Xenopus laevis	100-104
33172093-8	2020	In summary, cordycepin inhibited FGF9-induced testicular tumor growth by suppressing the ERK1/2, Rb/E2F1, cell cycle pathways, and the expressions of FGFR1-4 proteins, suggesting that cordycepin can be used as a novel anticancer drug for testicular cancers.	cordycepin	12-22	fibroblast growth factor receptor 1 L homeolog	Xenopus laevis	150-157
33172093-8	2020	In summary, cordycepin inhibited FGF9-induced testicular tumor growth by suppressing the ERK1/2, Rb/E2F1, cell cycle pathways, and the expressions of FGFR1-4 proteins, suggesting that cordycepin can be used as a novel anticancer drug for testicular cancers.	cordycepin	184-194	fibroblast growth factor 9 S homeolog	Xenopus laevis	33-37
33014856-0	2020	Combination of Cordycepin and Apatinib Synergistically Inhibits NSCLC Cells by Down-Regulating VEGF/PI3K/Akt Signaling Pathway.	cordycepin	15-25	vascular endothelial growth factor A	Homo sapiens	95-99
33014856-0	2020	Combination of Cordycepin and Apatinib Synergistically Inhibits NSCLC Cells by Down-Regulating VEGF/PI3K/Akt Signaling Pathway.	cordycepin	15-25	AKT serine/threonine kinase 1	Homo sapiens	105-108
33014856-7	2020	The VEGF/PI3K/Akt pathway was inhibited after treatment with cordycepin and apatinib.	cordycepin	61-71	vascular endothelial growth factor A	Homo sapiens	4-8
33014856-7	2020	The VEGF/PI3K/Akt pathway was inhibited after treatment with cordycepin and apatinib.	cordycepin	61-71	AKT serine/threonine kinase 1	Homo sapiens	14-17
33014856-8	2020	Conclusion: Our findings demonstrated that the combination of cordycepin and apatinib has synergistically anticancer effect on NSCLC cells by down-regulating VEGF/PI3K/Akt signaling pathway.	cordycepin	62-72	vascular endothelial growth factor A	Homo sapiens	158-162
33014856-8	2020	Conclusion: Our findings demonstrated that the combination of cordycepin and apatinib has synergistically anticancer effect on NSCLC cells by down-regulating VEGF/PI3K/Akt signaling pathway.	cordycepin	62-72	AKT serine/threonine kinase 1	Homo sapiens	168-171
32376767-3	2020	Pharmacological perturbation of RUVBL2 with the adenosine analog compound cordycepin resulted in a rapid-onset 12-hour clock phase-shift phenotype at human cell, mouse tissue, and whole-animal live imaging levels.	cordycepin	74-84	RuvB like AAA ATPase 2	Homo sapiens	32-38
32376767-5	2020	We solved a crystal structure for human RUVBL2 in complex with a physiological metabolite of cordycepin, and biochemical assays showed that cordycepin treatment caused disassembly of an interaction between RUVBL2 and the core clock component BMAL1.	cordycepin	93-103	RuvB like AAA ATPase 2	Homo sapiens	40-46
32376767-5	2020	We solved a crystal structure for human RUVBL2 in complex with a physiological metabolite of cordycepin, and biochemical assays showed that cordycepin treatment caused disassembly of an interaction between RUVBL2 and the core clock component BMAL1.	cordycepin	93-103	RuvB like AAA ATPase 2	Homo sapiens	206-212
32163051-3	2020	Cordycepin-induced apoptosis led to increased PUMA, CYTO-C, FAS, DR4/5, and cleaved caspase-3; and decreased BCL-2, XIAP and PDGFR-alpha.	cordycepin	0-10	caspase 3	Homo sapiens	84-93
32163051-3	2020	Cordycepin-induced apoptosis led to increased PUMA, CYTO-C, FAS, DR4/5, and cleaved caspase-3; and decreased BCL-2, XIAP and PDGFR-alpha.	cordycepin	0-10	BCL2 apoptosis regulator	Homo sapiens	109-114
32163051-3	2020	Cordycepin-induced apoptosis led to increased PUMA, CYTO-C, FAS, DR4/5, and cleaved caspase-3; and decreased BCL-2, XIAP and PDGFR-alpha.	cordycepin	0-10	X-linked inhibitor of apoptosis	Homo sapiens	116-120
32163051-3	2020	Cordycepin-induced apoptosis led to increased PUMA, CYTO-C, FAS, DR4/5, and cleaved caspase-3; and decreased BCL-2, XIAP and PDGFR-alpha.	cordycepin	0-10	platelet derived growth factor receptor alpha	Homo sapiens	125-136
33520990-0	2020	Cordycepin Reverses Cisplatin Resistance in Non-small Cell Lung Cancer by Activating AMPK and Inhibiting AKT Signaling Pathway.	cordycepin	0-10	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	85-89
33520990-0	2020	Cordycepin Reverses Cisplatin Resistance in Non-small Cell Lung Cancer by Activating AMPK and Inhibiting AKT Signaling Pathway.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	105-108
33520990-6	2020	The cell proliferation and apoptosis were analyzed in NSCLC parental (A549) and DDP-resistant (A549DDP) cells treated with DDP alone or in combination with Cor both in vitro and in vivo.	cordycepin	156-159	translocase of inner mitochondrial membrane 8A	Homo sapiens	80-83
33116402-0	2020	Cordycepin Alleviates Anterior Cruciate Ligament Transection (ACLT)-Induced Knee Osteoarthritis Through Regulating TGF-beta Activity and Autophagy [Retraction].	cordycepin	0-10	transforming growth factor alpha	Homo sapiens	115-123
32764880-0	2020	Cordycepin Alleviates Anterior Cruciate Ligament Transection (ACLT)-Induced Knee Osteoarthritis Through Regulating TGF-beta Activity and Autophagy.	cordycepin	0-10	transforming growth factor alpha	Rattus norvegicus	115-123
32764880-13	2020	However, the increase of serum TGF-beta level in ACLT rats was reversed by COR treatment in a dose-dependent manner.	cordycepin	75-78	transforming growth factor alpha	Rattus norvegicus	31-39
32764880-16	2020	The results showed that TGF-beta overexpression and 3-MA treatment reversed the effect of COR on autophagy.	cordycepin	90-93	transforming growth factor alpha	Rattus norvegicus	24-32
32764880-17	2020	Conclusion: In summary, our findings declared that COR alleviated ACLT-induced osteoarthritis pain and cartilage damage by inhibiting TGF-beta activity and inducing autophagy in rat model with knee osteoarthritis.	cordycepin	51-54	transforming growth factor alpha	Rattus norvegicus	134-142
32714076-10	2020	Cordycepin rescued the protective effects partially by decreasing ROS generation and restoring the expression of the salivary proteins, AMY and AQP5 via anti-oxidant and anti-apoptotic activity.	cordycepin	0-10	aquaporin 5	Homo sapiens	144-148
32268154-0	2020	Cordycepin protects against acute pancreatitis by modulating NF-kappaB and NLRP3 inflammasome activation via AMPK.	cordycepin	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	61-70
32268154-0	2020	Cordycepin protects against acute pancreatitis by modulating NF-kappaB and NLRP3 inflammasome activation via AMPK.	cordycepin	0-10	NLR family, pyrin domain containing 3	Mus musculus	75-80
32102917-14	2020	We reported that cordycepin inhibited the viability of CCA cells, induced apoptosis via extracellular signal-regulated kinase 1/2 deactivation and DEK inhibition, and reduced the angiogenetic capabilities of CCA both in vivo and in vitro.	cordycepin	17-27	mitogen-activated protein kinase 3	Homo sapiens	88-129
32102917-14	2020	We reported that cordycepin inhibited the viability of CCA cells, induced apoptosis via extracellular signal-regulated kinase 1/2 deactivation and DEK inhibition, and reduced the angiogenetic capabilities of CCA both in vivo and in vitro.	cordycepin	17-27	DEK proto-oncogene	Homo sapiens	147-150
31873836-5	2020	In this model, we found that cordycepin prevented against macrophage infiltration in paw tissue and reduced interferon-gamma (IFN-gamma) production in both serum and paw tissue.	cordycepin	29-39	interferon gamma	Mus musculus	108-124
31873836-5	2020	In this model, we found that cordycepin prevented against macrophage infiltration in paw tissue and reduced interferon-gamma (IFN-gamma) production in both serum and paw tissue.	cordycepin	29-39	interferon gamma	Mus musculus	126-135
31873836-6	2020	Using luciferase reporter assay, we found that cordycepin suppressed IFN-gamma-induced activators of transcription-1 (STAT1) transcriptional activity in a dose-dependent manner.	cordycepin	47-57	interferon gamma	Mus musculus	69-78
31873836-6	2020	Using luciferase reporter assay, we found that cordycepin suppressed IFN-gamma-induced activators of transcription-1 (STAT1) transcriptional activity in a dose-dependent manner.	cordycepin	47-57	signal transducer and activator of transcription 1	Mus musculus	118-123
31873836-7	2020	Moreover, western blotting data demonstrated that cordycepin inhibited IFN-gamma-induced STAT1 activation through attenuating STAT1 phosphorylation.	cordycepin	50-60	interferon gamma	Mus musculus	71-80
31873836-7	2020	Moreover, western blotting data demonstrated that cordycepin inhibited IFN-gamma-induced STAT1 activation through attenuating STAT1 phosphorylation.	cordycepin	50-60	signal transducer and activator of transcription 1	Mus musculus	89-94
31873836-7	2020	Moreover, western blotting data demonstrated that cordycepin inhibited IFN-gamma-induced STAT1 activation through attenuating STAT1 phosphorylation.	cordycepin	50-60	signal transducer and activator of transcription 1	Mus musculus	126-131
31873836-8	2020	Further investigations revealed that cordycepin inhibited the expressions of IFN-gamma-inducible protein 10 (IP-10) and monokine induced by IFN-gamma (Mig), which were the effector genes in IFN-gamma-induced STAT1 signaling.	cordycepin	37-47	chemokine (C-X-C motif) ligand 10	Mus musculus	77-107
31873836-8	2020	Further investigations revealed that cordycepin inhibited the expressions of IFN-gamma-inducible protein 10 (IP-10) and monokine induced by IFN-gamma (Mig), which were the effector genes in IFN-gamma-induced STAT1 signaling.	cordycepin	37-47	chemokine (C-X-C motif) ligand 10	Mus musculus	109-114
31873836-8	2020	Further investigations revealed that cordycepin inhibited the expressions of IFN-gamma-inducible protein 10 (IP-10) and monokine induced by IFN-gamma (Mig), which were the effector genes in IFN-gamma-induced STAT1 signaling.	cordycepin	37-47	chemokine (C-X-C motif) ligand 9	Mus musculus	120-149
31873836-8	2020	Further investigations revealed that cordycepin inhibited the expressions of IFN-gamma-inducible protein 10 (IP-10) and monokine induced by IFN-gamma (Mig), which were the effector genes in IFN-gamma-induced STAT1 signaling.	cordycepin	37-47	chemokine (C-X-C motif) ligand 9	Mus musculus	151-154
31873836-8	2020	Further investigations revealed that cordycepin inhibited the expressions of IFN-gamma-inducible protein 10 (IP-10) and monokine induced by IFN-gamma (Mig), which were the effector genes in IFN-gamma-induced STAT1 signaling.	cordycepin	37-47	interferon gamma	Mus musculus	77-86
31873836-8	2020	Further investigations revealed that cordycepin inhibited the expressions of IFN-gamma-inducible protein 10 (IP-10) and monokine induced by IFN-gamma (Mig), which were the effector genes in IFN-gamma-induced STAT1 signaling.	cordycepin	37-47	signal transducer and activator of transcription 1	Mus musculus	208-213
31873836-10	2020	These findings demonstrate that cordycepin alleviates excessive inflammatory cell infiltration through down-regulation of macrophage IP-10 and Mig expressions via suppressing STAT1 phosphorylation.	cordycepin	32-42	chemokine (C-X-C motif) ligand 10	Mus musculus	133-138
31873836-10	2020	These findings demonstrate that cordycepin alleviates excessive inflammatory cell infiltration through down-regulation of macrophage IP-10 and Mig expressions via suppressing STAT1 phosphorylation.	cordycepin	32-42	chemokine (C-X-C motif) ligand 9	Mus musculus	143-146
31873836-10	2020	These findings demonstrate that cordycepin alleviates excessive inflammatory cell infiltration through down-regulation of macrophage IP-10 and Mig expressions via suppressing STAT1 phosphorylation.	cordycepin	32-42	signal transducer and activator of transcription 1	Mus musculus	175-180
32163051-3	2020	Cordycepin-induced apoptosis led to increased PUMA, CYTO-C, FAS, DR4/5, and cleaved caspase-3; and decreased BCL-2, XIAP and PDGFR-alpha.	cordycepin	0-10	major histocompatibility complex, class II, DR beta 4	Homo sapiens	65-70
32131547-3	2020	Treatment with cordycepin or cisplatin (2 mug/mL) alone failed to induce cell death in T24R2 cells, but combination treatment with these drugs significantly induced apoptosis through mitochondrial pathways, including depolarization of mitochondrial membranes, decrease in anti-apoptotic proteins Bcl-2, Bcl-xL, and Mcl-1, and increase in pro-apoptotic proteins Bak and Bax.	cordycepin	15-25	BCL2 apoptosis regulator	Homo sapiens	296-301
32131547-3	2020	Treatment with cordycepin or cisplatin (2 mug/mL) alone failed to induce cell death in T24R2 cells, but combination treatment with these drugs significantly induced apoptosis through mitochondrial pathways, including depolarization of mitochondrial membranes, decrease in anti-apoptotic proteins Bcl-2, Bcl-xL, and Mcl-1, and increase in pro-apoptotic proteins Bak and Bax.	cordycepin	15-25	BCL2 like 1	Homo sapiens	303-309
32131547-3	2020	Treatment with cordycepin or cisplatin (2 mug/mL) alone failed to induce cell death in T24R2 cells, but combination treatment with these drugs significantly induced apoptosis through mitochondrial pathways, including depolarization of mitochondrial membranes, decrease in anti-apoptotic proteins Bcl-2, Bcl-xL, and Mcl-1, and increase in pro-apoptotic proteins Bak and Bax.	cordycepin	15-25	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	315-320
32131547-3	2020	Treatment with cordycepin or cisplatin (2 mug/mL) alone failed to induce cell death in T24R2 cells, but combination treatment with these drugs significantly induced apoptosis through mitochondrial pathways, including depolarization of mitochondrial membranes, decrease in anti-apoptotic proteins Bcl-2, Bcl-xL, and Mcl-1, and increase in pro-apoptotic proteins Bak and Bax.	cordycepin	15-25	BCL2 antagonist/killer 1	Homo sapiens	361-364
32131547-3	2020	Treatment with cordycepin or cisplatin (2 mug/mL) alone failed to induce cell death in T24R2 cells, but combination treatment with these drugs significantly induced apoptosis through mitochondrial pathways, including depolarization of mitochondrial membranes, decrease in anti-apoptotic proteins Bcl-2, Bcl-xL, and Mcl-1, and increase in pro-apoptotic proteins Bak and Bax.	cordycepin	15-25	BCL2 associated X, apoptosis regulator	Homo sapiens	369-372
31814895-3	2019	Immunoblotting showed that cordycepin increased Dickkopf-related protein 1 (Dkk1) levels and inhibited beta-catenin signaling.	cordycepin	27-37	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	48-74
32042022-4	2020	The expression levels of phospho-Jak2, phospho-Stat3, integrin alphaV, and integrin beta5 were increased after cordycepin treatment.	cordycepin	111-121	Janus kinase 2	Mus musculus	33-37
31845520-0	2020	A rapid assay to screen adenosine deaminase inhibitors from Ligustri Lucidi Fructus against metabolism of cordycepin utilizing ultra-high-performance liquid chromatography-tandem mass spectrometry.	cordycepin	106-116	adenosine deaminase	Homo sapiens	24-43
32042022-4	2020	The expression levels of phospho-Jak2, phospho-Stat3, integrin alphaV, and integrin beta5 were increased after cordycepin treatment.	cordycepin	111-121	signal transducer and activator of transcription 3	Mus musculus	47-52
32042022-4	2020	The expression levels of phospho-Jak2, phospho-Stat3, integrin alphaV, and integrin beta5 were increased after cordycepin treatment.	cordycepin	111-121	integrin beta 5	Mus musculus	75-89
32042022-9	2020	Taken together, we demonstrated that cordycepin maintained the pluripotency of stem cells via regulation of extracellular matrix (ECM) and Jak2/Stat3 signaling pathway and improved the generation efficiency of iPSCs.	cordycepin	37-47	Janus kinase 2	Mus musculus	139-143
32042022-9	2020	Taken together, we demonstrated that cordycepin maintained the pluripotency of stem cells via regulation of extracellular matrix (ECM) and Jak2/Stat3 signaling pathway and improved the generation efficiency of iPSCs.	cordycepin	37-47	signal transducer and activator of transcription 3	Mus musculus	144-149
31814895-3	2019	Immunoblotting showed that cordycepin increased Dickkopf-related protein 1 (Dkk1) levels and inhibited beta-catenin signaling.	cordycepin	27-37	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	76-80
31814895-3	2019	Immunoblotting showed that cordycepin increased Dickkopf-related protein 1 (Dkk1) levels and inhibited beta-catenin signaling.	cordycepin	27-37	catenin beta 1	Homo sapiens	103-115
31814895-4	2019	Atg7 knockdown in ovarian cancer cells significantly inhibited cordycepin-induced apoptosis, whereas beta-catenin overexpression abolished the effects of cordycepin on cell death and proliferation.	cordycepin	63-73	autophagy related 7	Homo sapiens	0-4
31814895-4	2019	Atg7 knockdown in ovarian cancer cells significantly inhibited cordycepin-induced apoptosis, whereas beta-catenin overexpression abolished the effects of cordycepin on cell death and proliferation.	cordycepin	154-164	catenin beta 1	Homo sapiens	101-113
31145545-7	2019	In summary, PERK-eIF2alpha signaling pathway is required for pro-apoptotic UPR in MA-10 cell death following cordycepin treatment, suggesting a potential therapeutic application in treating testicular cancer.	cordycepin	109-119	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	12-16
31314908-7	2019	These results suggested that cordycepin improved behavioral-LTP and morphological structure of dendrite in hippocampal CA1 but did not contribute to the improvement of learning and memory.	cordycepin	29-39	carbonic anhydrase 1	Rattus norvegicus	119-122
31314908-8	2019	And cordycepin improved behavioral-LTP may be through reducing the level of A2AR in hippocampus.	cordycepin	4-14	adenosine A2a receptor	Rattus norvegicus	76-80
30963194-0	2019	Interleukin-4 signalling pathway underlies the anxiolytic effect induced by 3-deoxyadenosine.	cordycepin	76-92	interleukin 4	Mus musculus	0-13
31357085-8	2019	Cordycepin also inhibited the CPZ-induced increase in the number of Iba1-positive microglia, GFAP-positive astrocytes and Olig2-positive oligodendroglial precursor cells in the corpus callosum and cerebral cortex.	cordycepin	0-10	induction of brown adipocytes 1	Mus musculus	68-72
31357085-8	2019	Cordycepin also inhibited the CPZ-induced increase in the number of Iba1-positive microglia, GFAP-positive astrocytes and Olig2-positive oligodendroglial precursor cells in the corpus callosum and cerebral cortex.	cordycepin	0-10	oligodendrocyte transcription factor 2	Mus musculus	122-127
31357085-9	2019	Pro-inflammatory cytokine expression (IL-1beta and IL-6) was inhibited while anti-inflammatory cytokine IL-4 and neurotrophic factor BDNF release was elevated in the corpus callosum and hippocampus after cordycepin treatment.	cordycepin	204-214	interleukin 4	Mus musculus	104-108
31357085-9	2019	Pro-inflammatory cytokine expression (IL-1beta and IL-6) was inhibited while anti-inflammatory cytokine IL-4 and neurotrophic factor BDNF release was elevated in the corpus callosum and hippocampus after cordycepin treatment.	cordycepin	204-214	brain derived neurotrophic factor	Mus musculus	133-137
31314908-0	2019	Cordycepin improves behavioral-LTP and dendritic structure in hippocampal CA1 area of rats.	cordycepin	0-10	carbonic anhydrase 1	Rattus norvegicus	74-77
31314908-6	2019	Furthermore, cordycepin obviously reduced A2AR level without altering adenosine A1 receptors level; and the agonist of A2AR (CGS 21680) rather than antagonist (SCH 58261) could reverse the potentiation of behavioral-LTP induced by cordycepin.	cordycepin	13-23	adenosine A2a receptor	Rattus norvegicus	42-46
31314908-6	2019	Furthermore, cordycepin obviously reduced A2AR level without altering adenosine A1 receptors level; and the agonist of A2AR (CGS 21680) rather than antagonist (SCH 58261) could reverse the potentiation of behavioral-LTP induced by cordycepin.	cordycepin	13-23	adenosine A2a receptor	Rattus norvegicus	119-123
31314908-6	2019	Furthermore, cordycepin obviously reduced A2AR level without altering adenosine A1 receptors level; and the agonist of A2AR (CGS 21680) rather than antagonist (SCH 58261) could reverse the potentiation of behavioral-LTP induced by cordycepin.	cordycepin	231-241	adenosine A2a receptor	Rattus norvegicus	119-123
30963194-9	2019	Furthermore, 3"-dA enhanced IL-4 expression after 45 min or 5 days, TNF-alpha and IL-1beta expression decreased significantly after a 5-day treatment with 3"-dA, and IL-10 expression increased after a 5-day treatment with 3"-dA or imipramine in the PFC.	cordycepin	13-18	interleukin 4	Mus musculus	28-32
30963194-9	2019	Furthermore, 3"-dA enhanced IL-4 expression after 45 min or 5 days, TNF-alpha and IL-1beta expression decreased significantly after a 5-day treatment with 3"-dA, and IL-10 expression increased after a 5-day treatment with 3"-dA or imipramine in the PFC.	cordycepin	155-160	tumor necrosis factor	Mus musculus	68-77
30963194-9	2019	Furthermore, 3"-dA enhanced IL-4 expression after 45 min or 5 days, TNF-alpha and IL-1beta expression decreased significantly after a 5-day treatment with 3"-dA, and IL-10 expression increased after a 5-day treatment with 3"-dA or imipramine in the PFC.	cordycepin	155-160	interleukin 1 alpha	Mus musculus	82-90
30963194-9	2019	Furthermore, 3"-dA enhanced IL-4 expression after 45 min or 5 days, TNF-alpha and IL-1beta expression decreased significantly after a 5-day treatment with 3"-dA, and IL-10 expression increased after a 5-day treatment with 3"-dA or imipramine in the PFC.	cordycepin	155-160	tumor necrosis factor	Mus musculus	68-77
30963194-9	2019	Furthermore, 3"-dA enhanced IL-4 expression after 45 min or 5 days, TNF-alpha and IL-1beta expression decreased significantly after a 5-day treatment with 3"-dA, and IL-10 expression increased after a 5-day treatment with 3"-dA or imipramine in the PFC.	cordycepin	155-160	interleukin 1 alpha	Mus musculus	82-90
31242974-0	2019	Cordycepin alleviates hepatic lipid accumulation by inducing protective autophagy via PKA/mTOR pathway.	cordycepin	0-10	mechanistic target of rapamycin kinase	Homo sapiens	90-94
31145545-7	2019	In summary, PERK-eIF2alpha signaling pathway is required for pro-apoptotic UPR in MA-10 cell death following cordycepin treatment, suggesting a potential therapeutic application in treating testicular cancer.	cordycepin	109-119	eukaryotic translation initiation factor 2A	Mus musculus	17-26
31182708-0	2019	Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.	cordycepin	0-10	NFE2 like bZIP transcription factor 2	Rattus norvegicus	70-74
31182708-0	2019	Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.	cordycepin	0-10	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	79-83
31182708-3	2019	Further more, we identify cordycepin, a natural nucleoside analogue, as a potent drug to block radiation ulcer (skin, intestine, tongue) in rats/mice by preventing cell senescence through the increase of NRF2 nuclear expression (the assay used is mainly on skin).	cordycepin	26-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	204-208
30717276-2	2019	3"-deoxyadenosine (cordycepin) is known to suppress FAK expression, cell migration, and the epithelial-mesenchymal transition in hepatocellular carcinoma (HCC).	cordycepin	0-17	PTK2 protein tyrosine kinase 2	Mus musculus	52-55
30878262-9	2019	CONCLUSION: Cordycepin inhibited the proliferation and migration of gastric cancer cells by upregulating CLEC2 via the Akt signaling pathway.	cordycepin	12-22	C-type lectin domain family 1 member B	Homo sapiens	105-110
31049139-11	2019	Cordycepin reduced the levels of TLR4, NF-kappaB, COX2, TNF-alpha, and IL-1beta in HEK293T cells too (P < 0.05).	cordycepin	0-10	toll like receptor 4	Homo sapiens	33-37
31049139-11	2019	Cordycepin reduced the levels of TLR4, NF-kappaB, COX2, TNF-alpha, and IL-1beta in HEK293T cells too (P < 0.05).	cordycepin	0-10	nuclear factor kappa B subunit 1	Homo sapiens	39-48
31049139-11	2019	Cordycepin reduced the levels of TLR4, NF-kappaB, COX2, TNF-alpha, and IL-1beta in HEK293T cells too (P < 0.05).	cordycepin	0-10	cox2	Cordyceps militaris	50-54
31049139-11	2019	Cordycepin reduced the levels of TLR4, NF-kappaB, COX2, TNF-alpha, and IL-1beta in HEK293T cells too (P < 0.05).	cordycepin	0-10	tumor necrosis factor	Homo sapiens	56-65
31049139-11	2019	Cordycepin reduced the levels of TLR4, NF-kappaB, COX2, TNF-alpha, and IL-1beta in HEK293T cells too (P < 0.05).	cordycepin	0-10	interleukin 1 beta	Homo sapiens	71-79
30717276-2	2019	3"-deoxyadenosine (cordycepin) is known to suppress FAK expression, cell migration, and the epithelial-mesenchymal transition in hepatocellular carcinoma (HCC).	cordycepin	19-29	PTK2 protein tyrosine kinase 2	Mus musculus	52-55
30535479-0	2019	Cordycepin induces Bax-dependent apoptosis in colorectal cancer cells.	cordycepin	0-10	BCL2 associated X, apoptosis regulator	Homo sapiens	19-22
30535479-6	2019	Treatment with cordycepin resulted in increased apoptosis in HCT116 cells; however, flow cytometic analysis demonstrated that apoptosis was notably decreased in the Bax-/- HCT116 cell lines, but not in the p53-/- HCT116 cell lines.	cordycepin	15-25	BCL2 associated X, apoptosis regulator	Homo sapiens	165-168
30766785-6	2019	Cpn also increases the expression of uncoupling protein 1 (UCP1) and other thermogenic genes in WAT and 3T3-L1 differentiated adipocytes, in which AMP-activated protein kinase (AMPK) plays an important role.	cordycepin	0-3	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	37-57
30766785-6	2019	Cpn also increases the expression of uncoupling protein 1 (UCP1) and other thermogenic genes in WAT and 3T3-L1 differentiated adipocytes, in which AMP-activated protein kinase (AMPK) plays an important role.	cordycepin	0-3	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	59-63
30182857-11	2019	CONCLUSION: Our study suggests that cordycepin is effective against cervical cancer cells, and regulating cell cycle via cell cycle proteins, especially downregulating Cdk-2, and inducing apoptosis by generating ROS are among the mechanisms of anticancer activities of cordycepin.	cordycepin	36-46	cyclin dependent kinase 2	Homo sapiens	168-173
31527329-0	2019	Cordycepin induces apoptosis in human bladder cancer T24 cells through ROS-dependent inhibition of the PI3K/Akt signaling pathway.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	108-111
31527329-5	2019	Additionally, cordycepin increased the Bax/Bcl-2 ratio and truncation of Bid, and destroyed the integrity of mitochondria, which contributed to the cytosolic release of cytochrome c.	cordycepin	14-24	BCL2 associated X, apoptosis regulator	Homo sapiens	39-42
31527329-5	2019	Additionally, cordycepin increased the Bax/Bcl-2 ratio and truncation of Bid, and destroyed the integrity of mitochondria, which contributed to the cytosolic release of cytochrome c.	cordycepin	14-24	BCL2 apoptosis regulator	Homo sapiens	43-48
31527329-5	2019	Additionally, cordycepin increased the Bax/Bcl-2 ratio and truncation of Bid, and destroyed the integrity of mitochondria, which contributed to the cytosolic release of cytochrome c.	cordycepin	14-24	BH3 interacting domain death agonist	Homo sapiens	73-76
31527329-5	2019	Additionally, cordycepin increased the Bax/Bcl-2 ratio and truncation of Bid, and destroyed the integrity of mitochondria, which contributed to the cytosolic release of cytochrome c.	cordycepin	14-24	cytochrome c, somatic	Homo sapiens	169-181
31527329-6	2019	Moreover, cordycepin effectively inactivated the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, while LY294002, a PI3K/Akt inhibitor, increased the apoptosis-inducing effect of cordycepin.	cordycepin	10-20	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	49-74
31527329-6	2019	Moreover, cordycepin effectively inactivated the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, while LY294002, a PI3K/Akt inhibitor, increased the apoptosis-inducing effect of cordycepin.	cordycepin	10-20	AKT serine/threonine kinase 1	Homo sapiens	82-85
31527329-6	2019	Moreover, cordycepin effectively inactivated the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, while LY294002, a PI3K/Akt inhibitor, increased the apoptosis-inducing effect of cordycepin.	cordycepin	10-20	AKT serine/threonine kinase 1	Homo sapiens	128-131
31527329-7	2019	Cordycepin further enhanced the intracellular levels of reactive oxygen species (ROS), while the addition of N-acetyl cysteine (NAC), a ROS inhibitor, significantly diminished cordycepin-induced mitochondrial dysfunction and growth inhibition, and also blocked the inactivation of PI3K/Akt signaling pathway.	cordycepin	176-186	AKT serine/threonine kinase 1	Homo sapiens	286-289
31527329-9	2019	Collectively, the data indicate that cordycepin induces apoptosis through the activation of extrinsic and intrinsic apoptosis pathways and the ROS-dependent inactivation of PI3K/Akt signaling in human bladder cancer T24 cells.	cordycepin	37-47	AKT serine/threonine kinase 1	Homo sapiens	178-181
30219871-0	2019	Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado-Joseph disease models.	cordycepin	0-10	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	39-43
30219871-6	2019	We found that cordycepin treatment significantly reduced (i) the levels of mutant Atx3, (ii) the neuropathological abnormalities in a lentiviral mouse model, (iii) the motor and neuropathological deficits in a transgenic mouse model and (iv) the number of ubiquitin aggregates in a human neural model.	cordycepin	14-24	ataxin 3	Mus musculus	82-86
30081068-0	2018	beta-catenin contributes to cordycepin-induced MGMT inhibition and reduction of temozolomide resistance in glioma cells by increasing intracellular reactive oxygen species.	cordycepin	28-38	catenin beta 1	Homo sapiens	0-12
30336060-0	2018	Cordycepin Augments the Chemosensitivity of Human Glioma Cells to Temozolomide by Activating AMPK and Inhibiting the AKT Signaling Pathway.	cordycepin	0-10	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	93-97
30336060-0	2018	Cordycepin Augments the Chemosensitivity of Human Glioma Cells to Temozolomide by Activating AMPK and Inhibiting the AKT Signaling Pathway.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	117-120
30336060-13	2018	Moreover, we also demonstrated that cordycepin effectively enhanced the activation of AMPK and suppressed the activity of AKT, whose activation was only induced by TMZ.	cordycepin	36-46	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	86-90
30336060-13	2018	Moreover, we also demonstrated that cordycepin effectively enhanced the activation of AMPK and suppressed the activity of AKT, whose activation was only induced by TMZ.	cordycepin	36-46	AKT serine/threonine kinase 1	Homo sapiens	122-125
30336060-14	2018	Furthermore, there was an apparent reduction in the expression levels of p-mTOR, p-p70S6K, matrix metalloproteinase (MMP)-2, and MMP-9 in the group treated with both cordycepin and TMZ, in comparison with those in the groups treated with either cordycepin or TMZ alone.	cordycepin	166-176	mechanistic target of rapamycin kinase	Homo sapiens	75-79
30336060-14	2018	Furthermore, there was an apparent reduction in the expression levels of p-mTOR, p-p70S6K, matrix metalloproteinase (MMP)-2, and MMP-9 in the group treated with both cordycepin and TMZ, in comparison with those in the groups treated with either cordycepin or TMZ alone.	cordycepin	166-176	matrix metallopeptidase 2	Homo sapiens	91-123
30336060-14	2018	Furthermore, there was an apparent reduction in the expression levels of p-mTOR, p-p70S6K, matrix metalloproteinase (MMP)-2, and MMP-9 in the group treated with both cordycepin and TMZ, in comparison with those in the groups treated with either cordycepin or TMZ alone.	cordycepin	166-176	matrix metallopeptidase 9	Homo sapiens	129-134
30081068-0	2018	beta-catenin contributes to cordycepin-induced MGMT inhibition and reduction of temozolomide resistance in glioma cells by increasing intracellular reactive oxygen species.	cordycepin	28-38	O-6-methylguanine-DNA methyltransferase	Homo sapiens	47-51
30081068-8	2018	However, whether cordycepin inhibits MGMT expression by downregulating the beta catenin pathway and augmenting chemosensitivity to TMZ in glioma cells remains unclear.	cordycepin	17-27	O-6-methylguanine-DNA methyltransferase	Homo sapiens	37-41
30081068-11	2018	We also found that cordycepin inhibited MGMT expression and augmented chemosensitivity to TMZ in glioma cells in vitro and in vivo, accompanied by downregulation of p-GSK-3beta and beta-catenin.	cordycepin	19-29	O-6-methylguanine-DNA methyltransferase	Homo sapiens	40-44
30081068-11	2018	We also found that cordycepin inhibited MGMT expression and augmented chemosensitivity to TMZ in glioma cells in vitro and in vivo, accompanied by downregulation of p-GSK-3beta and beta-catenin.	cordycepin	19-29	glycogen synthase kinase 3 beta	Homo sapiens	167-176
30081068-11	2018	We also found that cordycepin inhibited MGMT expression and augmented chemosensitivity to TMZ in glioma cells in vitro and in vivo, accompanied by downregulation of p-GSK-3beta and beta-catenin.	cordycepin	19-29	catenin beta 1	Homo sapiens	181-193
30081068-13	2018	Pharmacological inhibition of GSK-3beta with CHIR-99021 or overexpression of beta-catenin reversed cordycepin-induced reduction of cell viability, downregulation of beta-catenin and MGMT, increase of apoptosis and reduction of TMZ resistance.	cordycepin	99-109	glycogen synthase kinase 3 beta	Homo sapiens	30-39
30081068-13	2018	Pharmacological inhibition of GSK-3beta with CHIR-99021 or overexpression of beta-catenin reversed cordycepin-induced reduction of cell viability, downregulation of beta-catenin and MGMT, increase of apoptosis and reduction of TMZ resistance.	cordycepin	99-109	catenin beta 1	Homo sapiens	77-89
30081068-13	2018	Pharmacological inhibition of GSK-3beta with CHIR-99021 or overexpression of beta-catenin reversed cordycepin-induced reduction of cell viability, downregulation of beta-catenin and MGMT, increase of apoptosis and reduction of TMZ resistance.	cordycepin	99-109	catenin beta 1	Homo sapiens	165-177
30081068-13	2018	Pharmacological inhibition of GSK-3beta with CHIR-99021 or overexpression of beta-catenin reversed cordycepin-induced reduction of cell viability, downregulation of beta-catenin and MGMT, increase of apoptosis and reduction of TMZ resistance.	cordycepin	99-109	O-6-methylguanine-DNA methyltransferase	Homo sapiens	182-186
30081068-15	2018	Inhibition of ROS production with N-acetyl-l-cysteine (NAC) not only rescued the reduction of cell viability but also eliminated beta-catenin and MGMT inhibition, prevented glioma cells apoptosis and reversed the synergistic effect of cordycepin and TMZ.	cordycepin	235-245	X-linked Kx blood group	Homo sapiens	55-58
29702279-0	2018	Cordycepin alleviates lipopolysaccharide-induced acute lung injury via Nrf2/HO-1 pathway.	cordycepin	0-10	NFE2 like bZIP transcription factor 2	Rattus norvegicus	71-75
30031108-0	2018	Neuroprotective effects of cordycepin inhibit Abeta-induced apoptosis in hippocampal neurons.	cordycepin	27-37	amyloid beta precursor protein	Homo sapiens	46-51
30031108-2	2018	Cordycepin is a derivative of the nucleoside adenosine; also, it is speculated to exert neuroprotective effects against Abeta-induced oxidative toxicity in hippocampal neurons.	cordycepin	0-10	amyloid beta precursor protein	Homo sapiens	120-125
30031108-6	2018	Cordycepin inhibits ROS production, elevated levels of Ca2+ induced by Abeta25-35, and the activation of acetylcholinesterase; all these are involved in oxidative-induced apoptosis.	cordycepin	0-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-125
30269738-0	2018	Cordycepin inhibits lipopolysaccharide-induced cell migration and invasion in human colorectal carcinoma HCT-116 cells through down-regulation of prostaglandin E2 receptor EP4.	cordycepin	0-10	prostaglandin E receptor 4	Homo sapiens	172-175
30269738-4	2018	Our data indicate that cordycepin suppressed lipopolysaccharide (LPS)-enhanced cell migration and invasion through the inactivation of matrix metalloproteinase (MMP)-9 as well as the down-regulation of COX-2 expression and PGE2 production.	cordycepin	23-33	matrix metallopeptidase 9	Homo sapiens	135-167
30269738-4	2018	Our data indicate that cordycepin suppressed lipopolysaccharide (LPS)-enhanced cell migration and invasion through the inactivation of matrix metalloproteinase (MMP)-9 as well as the down-regulation of COX-2 expression and PGE2 production.	cordycepin	23-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	202-207
30269738-7	2018	However, the AMPK inhibitor, compound C, as well as AMPK knockdown via siRNA, attenuated the cordycepin-induced inhibition of EP4 expression.	cordycepin	93-103	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	13-17
30269738-7	2018	However, the AMPK inhibitor, compound C, as well as AMPK knockdown via siRNA, attenuated the cordycepin-induced inhibition of EP4 expression.	cordycepin	93-103	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	52-56
30269738-7	2018	However, the AMPK inhibitor, compound C, as well as AMPK knockdown via siRNA, attenuated the cordycepin-induced inhibition of EP4 expression.	cordycepin	93-103	prostaglandin E receptor 4	Homo sapiens	126-129
29702279-0	2018	Cordycepin alleviates lipopolysaccharide-induced acute lung injury via Nrf2/HO-1 pathway.	cordycepin	0-10	heme oxygenase 1	Rattus norvegicus	76-80
29702279-10	2018	RESULTS: Cordycepin enhanced the expression and enzymatic activity of HO-1 in ALI rats, and activated Nrf2 by inducing the translocation of Nrf2 from cytoplasm to nucleus.	cordycepin	9-19	heme oxygenase 1	Rattus norvegicus	70-74
29702279-10	2018	RESULTS: Cordycepin enhanced the expression and enzymatic activity of HO-1 in ALI rats, and activated Nrf2 by inducing the translocation of Nrf2 from cytoplasm to nucleus.	cordycepin	9-19	NFE2 like bZIP transcription factor 2	Rattus norvegicus	102-106
29702279-10	2018	RESULTS: Cordycepin enhanced the expression and enzymatic activity of HO-1 in ALI rats, and activated Nrf2 by inducing the translocation of Nrf2 from cytoplasm to nucleus.	cordycepin	9-19	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-144
28987792-7	2018	Besides, cordycepin induced the generation of reactive oxygen species (ROS) along with the suppression of antioxidant genes, including GPX, SOD, and Catalase.	cordycepin	9-19	catalase	Homo sapiens	149-157
29844932-0	2018	Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-kappaB signaling pathway.	cordycepin	0-10	C-C motif chemokine ligand 5	Homo sapiens	73-77
29844932-0	2018	Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-kappaB signaling pathway.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	87-90
29844932-6	2018	In addition to activating caspases, we show that, cordycepin prevents TNF-alpha-induced increase in CCL5, Akt, NF-kappaB, and c-FLIPL activation and that CCL5 siRNA could inhibit Akt/NF-kappaB signaling.	cordycepin	50-60	tumor necrosis factor	Homo sapiens	70-79
29844932-6	2018	In addition to activating caspases, we show that, cordycepin prevents TNF-alpha-induced increase in CCL5, Akt, NF-kappaB, and c-FLIPL activation and that CCL5 siRNA could inhibit Akt/NF-kappaB signaling.	cordycepin	50-60	C-C motif chemokine ligand 5	Homo sapiens	100-104
29844932-6	2018	In addition to activating caspases, we show that, cordycepin prevents TNF-alpha-induced increase in CCL5, Akt, NF-kappaB, and c-FLIPL activation and that CCL5 siRNA could inhibit Akt/NF-kappaB signaling.	cordycepin	50-60	AKT serine/threonine kinase 1	Homo sapiens	106-109
29844932-6	2018	In addition to activating caspases, we show that, cordycepin prevents TNF-alpha-induced increase in CCL5, Akt, NF-kappaB, and c-FLIPL activation and that CCL5 siRNA could inhibit Akt/NF-kappaB signaling.	cordycepin	50-60	CASP8 and FADD like apoptosis regulator	Homo sapiens	126-133
29844932-6	2018	In addition to activating caspases, we show that, cordycepin prevents TNF-alpha-induced increase in CCL5, Akt, NF-kappaB, and c-FLIPL activation and that CCL5 siRNA could inhibit Akt/NF-kappaB signaling.	cordycepin	50-60	AKT serine/threonine kinase 1	Homo sapiens	179-182
29844932-10	2018	SP600125, a selective JNK inhibitor, downregulated p-JNK expression in cordycepin-treated SKOV-3 cells, leading to suppression of cordycepin-induced apoptosis.	cordycepin	71-81	mitogen-activated protein kinase 8	Homo sapiens	22-25
29844932-10	2018	SP600125, a selective JNK inhibitor, downregulated p-JNK expression in cordycepin-treated SKOV-3 cells, leading to suppression of cordycepin-induced apoptosis.	cordycepin	71-81	mitogen-activated protein kinase 8	Homo sapiens	53-56
29844932-11	2018	Thus, these results indicate that cordycepin inhibits CCL5-mediated Akt/NF-kappaB signaling, which upregulates caspase-3 activation in SKOV-3 cells, supporting the potential of cordycepin as a therapeutic agent for ovarian cancer.	cordycepin	34-44	C-C motif chemokine ligand 5	Homo sapiens	54-58
29844932-11	2018	Thus, these results indicate that cordycepin inhibits CCL5-mediated Akt/NF-kappaB signaling, which upregulates caspase-3 activation in SKOV-3 cells, supporting the potential of cordycepin as a therapeutic agent for ovarian cancer.	cordycepin	34-44	AKT serine/threonine kinase 1	Homo sapiens	68-71
29844932-11	2018	Thus, these results indicate that cordycepin inhibits CCL5-mediated Akt/NF-kappaB signaling, which upregulates caspase-3 activation in SKOV-3 cells, supporting the potential of cordycepin as a therapeutic agent for ovarian cancer.	cordycepin	34-44	caspase 3	Homo sapiens	111-120
29844932-11	2018	Thus, these results indicate that cordycepin inhibits CCL5-mediated Akt/NF-kappaB signaling, which upregulates caspase-3 activation in SKOV-3 cells, supporting the potential of cordycepin as a therapeutic agent for ovarian cancer.	cordycepin	177-187	C-C motif chemokine ligand 5	Homo sapiens	54-58
29844932-11	2018	Thus, these results indicate that cordycepin inhibits CCL5-mediated Akt/NF-kappaB signaling, which upregulates caspase-3 activation in SKOV-3 cells, supporting the potential of cordycepin as a therapeutic agent for ovarian cancer.	cordycepin	177-187	caspase 3	Homo sapiens	111-120
29382532-0	2018	Cordycepin rescues lidocaine-induced neurotoxicity in dorsal root ganglion by interacting with inflammatory signaling pathway MMP3.	cordycepin	0-10	matrix metallopeptidase 3	Rattus norvegicus	126-130
29735437-8	2018	CONCLUSION: Cordycepin inhibits the proliferation and induces apoptosis of HCT-116 cells through the mitochondrial pathway and induces autophagy via the AMPK/mTOR pathway.	cordycepin	12-22	mechanistic target of rapamycin kinase	Homo sapiens	158-162
29522490-8	2018	Some bioactive compounds from EEAC, such as cordycepin and zhankuic acid A, were demonstrated to reduce the protein expressions of matrix metalloproteinase (MMP)-9 and cyclin D1 in A549 cells.	cordycepin	44-54	matrix metallopeptidase 9	Homo sapiens	131-163
29522490-8	2018	Some bioactive compounds from EEAC, such as cordycepin and zhankuic acid A, were demonstrated to reduce the protein expressions of matrix metalloproteinase (MMP)-9 and cyclin D1 in A549 cells.	cordycepin	44-54	cyclin D1	Homo sapiens	168-177
30124145-0	2018	Cordycepin Modulates Body Weight by Reducing Prolactin Via an Adenosine A1 Receptor.	cordycepin	0-10	adenosine A1 receptor	Rattus norvegicus	62-83
29054740-0	2018	Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress.	cordycepin	0-10	toll-like receptor 4	Mus musculus	20-23
30124145-9	2018	In vitro, cordycepin inhibited prolactin secretion in GH3 cells via upregulating the expression of adenosine A1 receptor, and the inhibition effect was blocked by an antagonist of adenosine receptor A1 DPDPX, demonstrating that cordycepin may work as an adenosine agonist.	cordycepin	10-20	adenosine A1 receptor	Rattus norvegicus	99-120
30124145-9	2018	In vitro, cordycepin inhibited prolactin secretion in GH3 cells via upregulating the expression of adenosine A1 receptor, and the inhibition effect was blocked by an antagonist of adenosine receptor A1 DPDPX, demonstrating that cordycepin may work as an adenosine agonist.	cordycepin	10-20	adenosine A1 receptor	Rattus norvegicus	180-201
30124145-9	2018	In vitro, cordycepin inhibited prolactin secretion in GH3 cells via upregulating the expression of adenosine A1 receptor, and the inhibition effect was blocked by an antagonist of adenosine receptor A1 DPDPX, demonstrating that cordycepin may work as an adenosine agonist.	cordycepin	228-238	adenosine A1 receptor	Rattus norvegicus	180-201
30124145-10	2018	Additionally, cordycepin inhibited the ERK/AKT/PI3K pathway in GH3 cells.	cordycepin	14-24	Eph receptor B1	Rattus norvegicus	39-42
30124145-10	2018	Additionally, cordycepin inhibited the ERK/AKT/PI3K pathway in GH3 cells.	cordycepin	14-24	AKT serine/threonine kinase 1	Rattus norvegicus	43-46
28962083-0	2017	Cordycepin inhibits LPS-induced inflammatory responses by modulating NOD-Like Receptor Protein 3 inflammasome activation.	cordycepin	0-10	NLR family, pyrin domain containing 3	Mus musculus	69-96
29340100-5	2017	After treating with 100 muM of Cd, cell viability, the percentage of cancer stem cells, and the levels of matrix metalloproteinases (MMPs) were decreased in TGF-beta-induced SKOV-3 cells.	cordycepin	31-33	transforming growth factor beta 1	Homo sapiens	157-165
29340100-6	2017	Treatment of Cd recovered E-cadherin levels and inhibited vimentin levels while TGF-beta treatment significantly increased the expression of vimentin and PGC-1alpha, and decreased E-cadherin levels in SKOV-3 cells, indicating that the action of Cd on cancer stemness may contribute to the regulation of epithelial-mesenchymal transition (EMT).	cordycepin	13-15	cadherin 1	Homo sapiens	26-36
29340100-6	2017	Treatment of Cd recovered E-cadherin levels and inhibited vimentin levels while TGF-beta treatment significantly increased the expression of vimentin and PGC-1alpha, and decreased E-cadherin levels in SKOV-3 cells, indicating that the action of Cd on cancer stemness may contribute to the regulation of epithelial-mesenchymal transition (EMT).	cordycepin	13-15	vimentin	Homo sapiens	58-66
29340100-6	2017	Treatment of Cd recovered E-cadherin levels and inhibited vimentin levels while TGF-beta treatment significantly increased the expression of vimentin and PGC-1alpha, and decreased E-cadherin levels in SKOV-3 cells, indicating that the action of Cd on cancer stemness may contribute to the regulation of epithelial-mesenchymal transition (EMT).	cordycepin	245-247	transforming growth factor beta 1	Homo sapiens	80-88
29340100-7	2017	Cd efficiently attenuated chemoresistance caused by TGF-beta in SKOV-3 cancer stem cells to promote the cytotoxicity of cisplatin.	cordycepin	0-2	transforming growth factor beta 1	Homo sapiens	52-60
29051060-7	2017	However, the 5"-nucleotidase activity decreased significantly in infected untreated animals and the same occurred in infected and treated animals with deoxycoformycin and 3"-deoxyadenosine.	cordycepin	171-188	5' nucleotidase, ecto	Mus musculus	13-28
29051060-8	2017	However, treatment with deoxycoformycin associated with 3"-deoxyadenosine preventing them from decreasing the 5"-nucleotidase activity.	cordycepin	56-73	5' nucleotidase, ecto	Mus musculus	110-125
28968944-0	2017	Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-kappaB pathway in mice.	cordycepin	31-41	thymoma viral proto-oncogene 1	Mus musculus	102-105
28401330-0	2017	Cordycepin confers neuroprotection in mice models of intracerebral hemorrhage via suppressing NLRP3 inflammasome activation.	cordycepin	0-10	NLR family, pyrin domain containing 3	Mus musculus	94-99
28968944-0	2017	Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-kappaB pathway in mice.	cordycepin	31-41	mechanistic target of rapamycin kinase	Mus musculus	106-110
28968944-0	2017	Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-kappaB pathway in mice.	cordycepin	31-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119
28968944-0	2017	Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-kappaB pathway in mice.	cordycepin	31-41	heme oxygenase 1	Mus musculus	120-124
28968944-0	2017	Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-kappaB pathway in mice.	cordycepin	31-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-134
29212261-0	2017	Cordycepin stimulates autophagy in macrophages and prevents atherosclerotic plaque formation in ApoE-/- mice.	cordycepin	0-10	apolipoprotein E	Mus musculus	96-100
29212261-2	2017	Here we show that cordycepin (Cpn), a natural derivative of adenosine, markedly reduced atherosclerotic plaque and ameliorated associated symptoms such as dyslipidemia, hyperglycemia and inflammation in ApoE-/- mice.	cordycepin	18-28	apolipoprotein E	Mus musculus	203-207
29212261-2	2017	Here we show that cordycepin (Cpn), a natural derivative of adenosine, markedly reduced atherosclerotic plaque and ameliorated associated symptoms such as dyslipidemia, hyperglycemia and inflammation in ApoE-/- mice.	cordycepin	30-33	apolipoprotein E	Mus musculus	203-207
28912858-0	2017	Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway.	cordycepin	0-10	mitogen-activated protein kinase 1	Homo sapiens	95-98
28912858-0	2017	Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	99-102
28962164-0	2017	Cordycepin inhibits vascular adhesion molecule expression in TNF-alpha-stimulated vascular muscle cells.	cordycepin	0-10	tumor necrosis factor	Homo sapiens	61-70
28962164-5	2017	Cordycepin significantly inhibited the TNF-alpha-induced mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) activation (P<0.05), markedly inhibited the TNF-alpha-induced expression level of nuclear factor (NF)-kappaB p65 and markedly prevented the TNF-alpha-associated degradation of IkappaBalpha in HA-VSMCs.	cordycepin	0-10	tumor necrosis factor	Homo sapiens	39-48
28962164-5	2017	Cordycepin significantly inhibited the TNF-alpha-induced mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) activation (P<0.05), markedly inhibited the TNF-alpha-induced expression level of nuclear factor (NF)-kappaB p65 and markedly prevented the TNF-alpha-associated degradation of IkappaBalpha in HA-VSMCs.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	119-122
28962164-5	2017	Cordycepin significantly inhibited the TNF-alpha-induced mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) activation (P<0.05), markedly inhibited the TNF-alpha-induced expression level of nuclear factor (NF)-kappaB p65 and markedly prevented the TNF-alpha-associated degradation of IkappaBalpha in HA-VSMCs.	cordycepin	0-10	tumor necrosis factor	Homo sapiens	171-180
28962164-5	2017	Cordycepin significantly inhibited the TNF-alpha-induced mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) activation (P<0.05), markedly inhibited the TNF-alpha-induced expression level of nuclear factor (NF)-kappaB p65 and markedly prevented the TNF-alpha-associated degradation of IkappaBalpha in HA-VSMCs.	cordycepin	0-10	tumor necrosis factor	Homo sapiens	171-180
28962164-5	2017	Cordycepin significantly inhibited the TNF-alpha-induced mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) activation (P<0.05), markedly inhibited the TNF-alpha-induced expression level of nuclear factor (NF)-kappaB p65 and markedly prevented the TNF-alpha-associated degradation of IkappaBalpha in HA-VSMCs.	cordycepin	0-10	NFKB inhibitor alpha	Homo sapiens	303-315
29045468-0	2017	Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression.	cordycepin	0-10	mitogen-activated protein kinase kinase 7	Homo sapiens	73-77
29045468-0	2017	Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression.	cordycepin	0-10	mitogen-activated protein kinase 8	Homo sapiens	78-81
29045468-0	2017	Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression.	cordycepin	0-10	CASP8 and FADD like apoptosis regulator	Homo sapiens	122-129
29045468-5	2017	Specifically, cordycepin inhibited TNF-alpha-mediated NF-kappaB activation, which induced renal cancer cell apoptosis.	cordycepin	14-24	tumor necrosis factor	Homo sapiens	35-44
29045468-5	2017	Specifically, cordycepin inhibited TNF-alpha-mediated NF-kappaB activation, which induced renal cancer cell apoptosis.	cordycepin	14-24	nuclear factor kappa B subunit 1	Homo sapiens	54-63
29045468-7	2017	Furthermore, siRNA-mediated knockdown of GADD45B in cordycepin-treated TK-10 cells considerably increased MKK7 compared to cordycepin alone.	cordycepin	52-62	growth arrest and DNA damage inducible beta	Homo sapiens	41-48
29045468-7	2017	Furthermore, siRNA-mediated knockdown of GADD45B in cordycepin-treated TK-10 cells considerably increased MKK7 compared to cordycepin alone.	cordycepin	52-62	mitogen-activated protein kinase kinase 7	Homo sapiens	106-110
29045468-7	2017	Furthermore, siRNA-mediated knockdown of GADD45B in cordycepin-treated TK-10 cells considerably increased MKK7 compared to cordycepin alone.	cordycepin	123-133	growth arrest and DNA damage inducible beta	Homo sapiens	41-48
29045468-11	2017	Taken together, the results indicate that cordycepin inhibits TNF-alpha-mediated NF-kappaB/GADD45B signaling, which activates the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression, thus inducing TK-10 cell apoptosis.	cordycepin	42-52	tumor necrosis factor	Homo sapiens	62-71
29045468-11	2017	Taken together, the results indicate that cordycepin inhibits TNF-alpha-mediated NF-kappaB/GADD45B signaling, which activates the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression, thus inducing TK-10 cell apoptosis.	cordycepin	42-52	nuclear factor kappa B subunit 1	Homo sapiens	81-90
29045468-11	2017	Taken together, the results indicate that cordycepin inhibits TNF-alpha-mediated NF-kappaB/GADD45B signaling, which activates the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression, thus inducing TK-10 cell apoptosis.	cordycepin	42-52	growth arrest and DNA damage inducible beta	Homo sapiens	91-98
29045468-11	2017	Taken together, the results indicate that cordycepin inhibits TNF-alpha-mediated NF-kappaB/GADD45B signaling, which activates the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression, thus inducing TK-10 cell apoptosis.	cordycepin	42-52	mitogen-activated protein kinase kinase 7	Homo sapiens	130-134
29045468-11	2017	Taken together, the results indicate that cordycepin inhibits TNF-alpha-mediated NF-kappaB/GADD45B signaling, which activates the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression, thus inducing TK-10 cell apoptosis.	cordycepin	42-52	mitogen-activated protein kinase 8	Homo sapiens	135-138
29045468-11	2017	Taken together, the results indicate that cordycepin inhibits TNF-alpha-mediated NF-kappaB/GADD45B signaling, which activates the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression, thus inducing TK-10 cell apoptosis.	cordycepin	42-52	CASP8 and FADD like apoptosis regulator	Homo sapiens	179-186
28351780-0	2017	Cordycepin negatively modulates lipopolysaccharide-induced cytokine production by up-regulation of heme oxygenase-1.	cordycepin	0-10	heme oxygenase 1	Mus musculus	99-115
28714368-4	2017	Cordyceps militaris hot water extracts containing cordycepin was used to treat human T24 bladder carcinoma cells, and we found that Cordyceps militaris hot water extracts containing cordycepin decreased T24 cell survival in a dose-dependent manner, which was seemingly mediated by activation of A3 adenosine receptor and the subsequent inactivation of Akt pathways, resulting in increases in cleaved Caspase-3 and apoptosis.	cordycepin	50-60	AKT serine/threonine kinase 1	Homo sapiens	352-355
28351780-7	2017	RESULTS: Cordycepin induced the phosphorylation of c-Src and p47phox subunit of NADPH oxidase in RAW264.7 cells.	cordycepin	9-19	neutrophil cytosolic factor 1	Mus musculus	61-68
28401001-0	2017	Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway.	cordycepin	0-10	mitogen-activated protein kinase 1	Homo sapiens	88-91
28219709-0	2017	Cordycepin diminishes thymic stromal lymphopoietin-induced interleukin-13 production.	cordycepin	0-10	thymic stromal lymphopoietin	Homo sapiens	22-50
28219709-0	2017	Cordycepin diminishes thymic stromal lymphopoietin-induced interleukin-13 production.	cordycepin	0-10	interleukin 13	Homo sapiens	59-73
28401001-8	2017	Cordycepin inhibited LPS-induced stimulation of iNOS, NO, p-ERK, and Slug expression.	cordycepin	0-10	mitogen-activated protein kinase 1	Homo sapiens	60-63
28401001-0	2017	Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway.	cordycepin	0-10	snail family transcriptional repressor 2	Homo sapiens	92-96
28401001-8	2017	Cordycepin inhibited LPS-induced stimulation of iNOS, NO, p-ERK, and Slug expression.	cordycepin	0-10	snail family transcriptional repressor 2	Homo sapiens	69-73
28099944-0	2017	Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma.	cordycepin	0-10	caveolin 1	Homo sapiens	32-42
28401001-12	2017	Cordycepin-mediated inhibition of ERK led to a reduction in phospho-GSK3beta (p-GSK3beta) and Slug levels, whereas LiCl, an inhibitor of GSK3beta, upregulated p-GSK3beta and Slug.	cordycepin	0-10	mitogen-activated protein kinase 1	Homo sapiens	34-37
28401001-12	2017	Cordycepin-mediated inhibition of ERK led to a reduction in phospho-GSK3beta (p-GSK3beta) and Slug levels, whereas LiCl, an inhibitor of GSK3beta, upregulated p-GSK3beta and Slug.	cordycepin	0-10	glycogen synthase kinase 3 beta	Homo sapiens	68-76
28401001-12	2017	Cordycepin-mediated inhibition of ERK led to a reduction in phospho-GSK3beta (p-GSK3beta) and Slug levels, whereas LiCl, an inhibitor of GSK3beta, upregulated p-GSK3beta and Slug.	cordycepin	0-10	glycogen synthase kinase 3 beta	Homo sapiens	80-88
28401001-12	2017	Cordycepin-mediated inhibition of ERK led to a reduction in phospho-GSK3beta (p-GSK3beta) and Slug levels, whereas LiCl, an inhibitor of GSK3beta, upregulated p-GSK3beta and Slug.	cordycepin	0-10	snail family transcriptional repressor 2	Homo sapiens	94-98
28401001-12	2017	Cordycepin-mediated inhibition of ERK led to a reduction in phospho-GSK3beta (p-GSK3beta) and Slug levels, whereas LiCl, an inhibitor of GSK3beta, upregulated p-GSK3beta and Slug.	cordycepin	0-10	glycogen synthase kinase 3 beta	Homo sapiens	80-88
28401001-12	2017	Cordycepin-mediated inhibition of ERK led to a reduction in phospho-GSK3beta (p-GSK3beta) and Slug levels, whereas LiCl, an inhibitor of GSK3beta, upregulated p-GSK3beta and Slug.	cordycepin	0-10	glycogen synthase kinase 3 beta	Homo sapiens	80-88
28401001-12	2017	Cordycepin-mediated inhibition of ERK led to a reduction in phospho-GSK3beta (p-GSK3beta) and Slug levels, whereas LiCl, an inhibitor of GSK3beta, upregulated p-GSK3beta and Slug.	cordycepin	0-10	snail family transcriptional repressor 2	Homo sapiens	174-178
28197639-0	2017	Cordycepin induces apoptosis in SGC-7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	103-106
28197639-4	2017	Cordycepin incorporates mitochondrial-mediated apoptosis in SGC-7901 cells with the help of regulating mitochondrial extrinsic pathways by inhibition of A3AR and drive activation of DR3, which promote the activation of PI3K/Akt protein expression as well as collapse of mitochondrial membrane potential (MMP).	cordycepin	0-10	adenosine A3 receptor	Homo sapiens	153-157
28197639-4	2017	Cordycepin incorporates mitochondrial-mediated apoptosis in SGC-7901 cells with the help of regulating mitochondrial extrinsic pathways by inhibition of A3AR and drive activation of DR3, which promote the activation of PI3K/Akt protein expression as well as collapse of mitochondrial membrane potential (MMP).	cordycepin	0-10	TNF receptor superfamily member 25	Homo sapiens	182-185
28197639-4	2017	Cordycepin incorporates mitochondrial-mediated apoptosis in SGC-7901 cells with the help of regulating mitochondrial extrinsic pathways by inhibition of A3AR and drive activation of DR3, which promote the activation of PI3K/Akt protein expression as well as collapse of mitochondrial membrane potential (MMP).	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	224-227
28068557-6	2017	In addition, the protein phosphatase inhibitors calyculin A and okadaic acid blocked the cordycepin-mediated reduction in p-Akt, p-FAK and migration.	cordycepin	89-99	protein tyrosine kinase 2	Homo sapiens	131-134
28099944-0	2017	Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma.	cordycepin	0-10	mitogen-activated protein kinase 8	Homo sapiens	52-55
28099944-0	2017	Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma.	cordycepin	0-10	forkhead box O3	Homo sapiens	70-76
27988284-0	2017	Anti-effects of cordycepin to hypoxia-induced membrane depolarization on hippocampal CA1 pyramidal neuron.	cordycepin	16-26	carbonic anhydrase 1	Homo sapiens	85-88
27966445-0	2017	Antimetastatic effects of cordycepin mediated by the inhibition of mitochondrial activity and estrogen-related receptor alpha in human ovarian carcinoma cells.	cordycepin	26-36	estrogen related receptor alpha	Homo sapiens	94-125
28035061-0	2017	Cordycepin induces autophagy-mediated c-FLIPL degradation and leads to apoptosis in human non-small cell lung cancer cells.	cordycepin	0-10	CASP8 and FADD like apoptosis regulator	Homo sapiens	38-45
28035061-6	2017	Meanwhile, cordycepin stimulated autophagy through suppressing mTOR signaling pathway in lung cancer cells.	cordycepin	11-21	mechanistic target of rapamycin kinase	Homo sapiens	63-67
28035061-9	2017	Therefore, we conclude that cordycepin induces apoptosis through autophagy-mediated downregulation of c-FLIPL in human NSCLC cells.	cordycepin	28-38	CASP8 and FADD like apoptosis regulator	Homo sapiens	102-109
27966445-6	2017	After 24 h treatment, cordycepin suppresses epithelial-mesenchymal transition and migration in ovarian carcinoma cells through inhibiting estrogen-related receptor (ERR)-alpha.	cordycepin	22-32	estrogen related receptor alpha	Homo sapiens	138-175
27225448-8	2017	Furthermore, cordycepin suppressed the activation of extracellular signaling-regulated kinase (ERKs) and mammalian target of rapamycin (mTOR) in both PLC/PRF/5 and HepG2 cells.	cordycepin	13-23	mechanistic target of rapamycin kinase	Homo sapiens	105-134
27225448-8	2017	Furthermore, cordycepin suppressed the activation of extracellular signaling-regulated kinase (ERKs) and mammalian target of rapamycin (mTOR) in both PLC/PRF/5 and HepG2 cells.	cordycepin	13-23	mechanistic target of rapamycin kinase	Homo sapiens	136-140
27225448-8	2017	Furthermore, cordycepin suppressed the activation of extracellular signaling-regulated kinase (ERKs) and mammalian target of rapamycin (mTOR) in both PLC/PRF/5 and HepG2 cells.	cordycepin	13-23	heparan sulfate proteoglycan 2	Homo sapiens	150-153
28522898-4	2017	Further, cordycepin inhibited hepatic neutrophil and macrophage infiltration and prevented proinflammatory cytokine production possibly through suppressing TLR4 and NF-kappaB signaling transduction.	cordycepin	9-19	toll-like receptor 4	Mus musculus	156-160
29070781-0	2017	Cordycepin induces apoptotic cell death and inhibits cell migration in renal cell carcinoma via regulation of microRNA-21 and PTEN phosphatase.	cordycepin	0-10	microRNA 21	Homo sapiens	110-121
29070781-0	2017	Cordycepin induces apoptotic cell death and inhibits cell migration in renal cell carcinoma via regulation of microRNA-21 and PTEN phosphatase.	cordycepin	0-10	phosphatase and tensin homolog	Homo sapiens	126-130
29070781-6	2017	Block of cordycepin-induced microRNA-21 decrease or PTEN increase in Caki-1 cells by transfection of microRNA-21 mimic or PTEN siRNA significantly attenuated cordycepin-induced cell death and inhibition of cell migration.	cordycepin	9-19	microRNA 21	Homo sapiens	28-39
29070781-6	2017	Block of cordycepin-induced microRNA-21 decrease or PTEN increase in Caki-1 cells by transfection of microRNA-21 mimic or PTEN siRNA significantly attenuated cordycepin-induced cell death and inhibition of cell migration.	cordycepin	9-19	microRNA 21	Homo sapiens	101-112
29070781-6	2017	Block of cordycepin-induced microRNA-21 decrease or PTEN increase in Caki-1 cells by transfection of microRNA-21 mimic or PTEN siRNA significantly attenuated cordycepin-induced cell death and inhibition of cell migration.	cordycepin	9-19	phosphatase and tensin homolog	Homo sapiens	122-126
29070781-6	2017	Block of cordycepin-induced microRNA-21 decrease or PTEN increase in Caki-1 cells by transfection of microRNA-21 mimic or PTEN siRNA significantly attenuated cordycepin-induced cell death and inhibition of cell migration.	cordycepin	158-168	microRNA 21	Homo sapiens	28-39
29070781-6	2017	Block of cordycepin-induced microRNA-21 decrease or PTEN increase in Caki-1 cells by transfection of microRNA-21 mimic or PTEN siRNA significantly attenuated cordycepin-induced cell death and inhibition of cell migration.	cordycepin	158-168	phosphatase and tensin homolog	Homo sapiens	52-56
29070781-6	2017	Block of cordycepin-induced microRNA-21 decrease or PTEN increase in Caki-1 cells by transfection of microRNA-21 mimic or PTEN siRNA significantly attenuated cordycepin-induced cell death and inhibition of cell migration.	cordycepin	158-168	microRNA 21	Homo sapiens	101-112
29070781-6	2017	Block of cordycepin-induced microRNA-21 decrease or PTEN increase in Caki-1 cells by transfection of microRNA-21 mimic or PTEN siRNA significantly attenuated cordycepin-induced cell death and inhibition of cell migration.	cordycepin	158-168	phosphatase and tensin homolog	Homo sapiens	122-126
29070781-7	2017	Taken together, findings in present study suggested that cordycepin induced apoptotic cell death in renal cell carcinoma through regulation of microRNA-21 and PTEN phosphatase.	cordycepin	57-67	microRNA 21	Homo sapiens	143-154
29070781-7	2017	Taken together, findings in present study suggested that cordycepin induced apoptotic cell death in renal cell carcinoma through regulation of microRNA-21 and PTEN phosphatase.	cordycepin	57-67	phosphatase and tensin homolog	Homo sapiens	159-163
28848161-10	2017	However, these inhibitory effects were attenuated by cordycepin co-treatment at concentrations of 1 and 10 microg/mL Moreover, it was revealed that the osteo-protective effect of cordycepin was associated with modulation of the Wnt/beta-catenin pathway.	cordycepin	53-63	catenin beta 1	Homo sapiens	232-244
29225974-0	2017	Modulation Effects of Cordycepin on Voltage-Gated Sodium Channels in Rat Hippocampal CA1 Pyramidal Neurons in the Presence/Absence of Oxygen.	cordycepin	22-32	carbonic anhydrase 1	Rattus norvegicus	85-88
27689974-0	2016	Cordycepin Induces Apoptosis and Inhibits Proliferation of Human Lung Cancer Cell Line H1975 via Inhibiting the Phosphorylation of EGFR.	cordycepin	0-10	epidermal growth factor receptor	Homo sapiens	131-135
27439604-0	2016	Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway.	cordycepin	0-10	NK3 homeobox 2	Mus musculus	83-88
27439604-9	2016	Besides, cordycepin suppressed chondrocyte hypertrophy through PI3K/Bapx1 pathway and Notch signaling.	cordycepin	9-19	NK3 homeobox 2	Mus musculus	68-73
27646481-7	2016	Cordycepin was able to alleviate TBI-induced loss of tight junction proteins zonula occludens protein-1 (ZO-1) and occludin, which are important for BBB integrity.	cordycepin	0-10	occludin	Rattus norvegicus	105-123
27646481-9	2016	Furthermore, cordycepin inhibited NADPH oxidase (NOX) expression and activity following TBI, probably through NOX1, but not NOX2 and NOX4.	cordycepin	13-23	NADPH oxidase 1	Rattus norvegicus	110-114
27648363-0	2016	Cordycepin promotes apoptosis by modulating the ERK-JNK signaling pathway via DUSP5 in renal cancer cells.	cordycepin	0-10	mitogen-activated protein kinase 1	Homo sapiens	48-51
27648363-0	2016	Cordycepin promotes apoptosis by modulating the ERK-JNK signaling pathway via DUSP5 in renal cancer cells.	cordycepin	0-10	mitogen-activated protein kinase 8	Homo sapiens	52-55
27648363-0	2016	Cordycepin promotes apoptosis by modulating the ERK-JNK signaling pathway via DUSP5 in renal cancer cells.	cordycepin	0-10	dual specificity phosphatase 5	Homo sapiens	78-83
26303320-0	2015	Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways.	cordycepin	0-10	mitogen-activated protein kinase 14	Mus musculus	73-76
27446383-8	2016	In conclusion, cordycepin-induced apoptosis in HepG2 cells involved the extrinsic and intrinsic signaling pathway and was primarily regulated by the Bcl-2 family proteins.	cordycepin	15-25	BCL2 apoptosis regulator	Homo sapiens	149-154
27261571-8	2016	Cordycepin also inhibited cell apoptosis induced by 6-OHDA as observed in the reduction of cytochrome c release from the mitochondrial as well as the inhibition of caspase-3.	cordycepin	0-10	caspase 3	Rattus norvegicus	164-173
26443809-9	2016	After 45min or 5 days of treatment, 3"-dA enhanced GluR1 S845 phosphorylation in both the PFC and HIP.	cordycepin	36-41	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	51-56
26443809-10	2016	In addition, after 45min of treatment, 3"-dA significantly up-regulated GluR1 S845 phosphorylation and GluR1, but not GluR2 levels, at the synapses in the PFC.	cordycepin	39-44	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	72-77
26443809-10	2016	In addition, after 45min of treatment, 3"-dA significantly up-regulated GluR1 S845 phosphorylation and GluR1, but not GluR2 levels, at the synapses in the PFC.	cordycepin	39-44	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	103-108
26443809-11	2016	After 5 days of treatment, 3"-dA significantly enhanced GluR1 S845 phosphorylation and GluR1, but not GluR2, at the synapses in the PFC and HIP.	cordycepin	27-32	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	56-61
26443809-11	2016	After 5 days of treatment, 3"-dA significantly enhanced GluR1 S845 phosphorylation and GluR1, but not GluR2, at the synapses in the PFC and HIP.	cordycepin	27-32	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	87-92
26597532-1	2016	We first demonstrated that cordycepin inhibited cell growth and triggered apoptosis in U87MG cells with wild-type p53, but not in T98G cells with mutant-type p53.	cordycepin	27-37	tumor protein p53	Homo sapiens	114-117
26597532-3	2016	Cordycepin-induced apoptosis could be suppressed by only SB203580, a p38 MAPK-specific inhibitor.	cordycepin	0-10	mitogen-activated protein kinase 14	Homo sapiens	69-72
27104563-8	2016	In vitro results revealed that cordycepin inhibited receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclast differentiation, formation, fusion and bone resorption activity.	cordycepin	31-41	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	104-109
26725432-0	2016	Cordycepin Suppresses Thymic Stromal Lymphopoietin Expression via Blocking Caspase-1 and Receptor-Interacting Protein 2 Signaling Pathways in Mast Cells.	cordycepin	0-10	caspase 1	Homo sapiens	75-119
26725432-5	2016	Cordycepin also significantly reduced the phosphorylation of receptor-interacting protein 2 and inhibitory kappa B (IkappaB) kinase beta.	cordycepin	0-10	receptor interacting serine/threonine kinase 2	Homo sapiens	61-91
26725432-5	2016	Cordycepin also significantly reduced the phosphorylation of receptor-interacting protein 2 and inhibitory kappa B (IkappaB) kinase beta.	cordycepin	0-10	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	96-136
27744448-7	2016	3"-da can significantly improve the rate of small oocyte maturation in vitro and inhibits Cdc2 polyadenylation.	cordycepin	0-5	cyclin dependent kinase 1	Homo sapiens	90-94
26366090-7	2015	Moreover, cordycepin plus cisplatin and/or paclitaxel significantly induced cleavage of caspase-8, caspase-9, caspase-3, and poly ADP-ribose polymerase, and phosphorylation of c-Jun NH2-terminal kinase, extracellular signal-regulated kinase, p38, and p53 proteins in MA-10 cells.	cordycepin	10-20	caspase 8	Mus musculus	88-97
26366090-7	2015	Moreover, cordycepin plus cisplatin and/or paclitaxel significantly induced cleavage of caspase-8, caspase-9, caspase-3, and poly ADP-ribose polymerase, and phosphorylation of c-Jun NH2-terminal kinase, extracellular signal-regulated kinase, p38, and p53 proteins in MA-10 cells.	cordycepin	10-20	caspase 9	Mus musculus	99-108
26366090-7	2015	Moreover, cordycepin plus cisplatin and/or paclitaxel significantly induced cleavage of caspase-8, caspase-9, caspase-3, and poly ADP-ribose polymerase, and phosphorylation of c-Jun NH2-terminal kinase, extracellular signal-regulated kinase, p38, and p53 proteins in MA-10 cells.	cordycepin	10-20	caspase 3	Mus musculus	110-119
26366090-7	2015	Moreover, cordycepin plus cisplatin and/or paclitaxel significantly induced cleavage of caspase-8, caspase-9, caspase-3, and poly ADP-ribose polymerase, and phosphorylation of c-Jun NH2-terminal kinase, extracellular signal-regulated kinase, p38, and p53 proteins in MA-10 cells.	cordycepin	10-20	poly (ADP-ribose) polymerase family, member 1	Mus musculus	125-151
26366090-7	2015	Moreover, cordycepin plus cisplatin and/or paclitaxel significantly induced cleavage of caspase-8, caspase-9, caspase-3, and poly ADP-ribose polymerase, and phosphorylation of c-Jun NH2-terminal kinase, extracellular signal-regulated kinase, p38, and p53 proteins in MA-10 cells.	cordycepin	10-20	mitogen-activated protein kinase 14	Mus musculus	242-245
26366090-7	2015	Moreover, cordycepin plus cisplatin and/or paclitaxel significantly induced cleavage of caspase-8, caspase-9, caspase-3, and poly ADP-ribose polymerase, and phosphorylation of c-Jun NH2-terminal kinase, extracellular signal-regulated kinase, p38, and p53 proteins in MA-10 cells.	cordycepin	10-20	transformation related protein 53, pseudogene	Mus musculus	251-254
26366090-8	2015	CONCLUSION: Cordycepin plus cisplatin and/or paclitaxel can have an additive effect on apoptosis in MA-10 cells, with activation of caspase, mitogen-activated protein kinase, and p53 signal pathways.	cordycepin	12-22	transformation related protein 53, pseudogene	Mus musculus	179-182
26303320-3	2015	In the present study, we showed that cordycepin (3"-deoxyadenosine) selectively induced apoptosis in MA-10 mouse Leydig tumor cells through regulating the p38 MAPK and PI3K/AKT signaling pathways.	cordycepin	37-47	mitogen-activated protein kinase 14	Mus musculus	155-163
26303320-3	2015	In the present study, we showed that cordycepin (3"-deoxyadenosine) selectively induced apoptosis in MA-10 mouse Leydig tumor cells through regulating the p38 MAPK and PI3K/AKT signaling pathways.	cordycepin	49-66	mitogen-activated protein kinase 14	Mus musculus	155-163
26303320-5	2015	Cordycepin increased reactive oxygen species (ROS) levels, which is associated with the induction of apoptosis as characterized by positive Annexin V binding, activation of caspase-3, and cleavage of PARP.	cordycepin	0-10	annexin A5	Mus musculus	140-149
26303320-5	2015	Cordycepin increased reactive oxygen species (ROS) levels, which is associated with the induction of apoptosis as characterized by positive Annexin V binding, activation of caspase-3, and cleavage of PARP.	cordycepin	0-10	caspase 3	Mus musculus	173-182
26303320-5	2015	Cordycepin increased reactive oxygen species (ROS) levels, which is associated with the induction of apoptosis as characterized by positive Annexin V binding, activation of caspase-3, and cleavage of PARP.	cordycepin	0-10	poly (ADP-ribose) polymerase family, member 1	Mus musculus	200-204
25789604-5	2015	Also, cordycepin significantly inhibited RANKL-induced phosphorylation of p38 and NF-kappaB, but not that of other members of mitogen-activated protein kinase families.	cordycepin	6-16	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	41-46
25282637-4	2015	Cordycepin also attenuated the activation of phosphoinositide-3-kinase (PI3K)/Akt signaling, thereby reducing phosphorylation and nuclear translocation of hTERT.	cordycepin	0-10	AKT serine/threonine kinase 1	Homo sapiens	78-81
25789604-5	2015	Also, cordycepin significantly inhibited RANKL-induced phosphorylation of p38 and NF-kappaB, but not that of other members of mitogen-activated protein kinase families.	cordycepin	6-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	82-91
26672348-6	2015	The Western blot results showed, Cordycepin dose-dependently inhibited the entry of NF-kappaB p65 to nuclear in A59 cells.	cordycepin	33-43	RELA proto-oncogene, NF-kB subunit	Homo sapiens	84-97
25282637-4	2015	Cordycepin also attenuated the activation of phosphoinositide-3-kinase (PI3K)/Akt signaling, thereby reducing phosphorylation and nuclear translocation of hTERT.	cordycepin	0-10	telomerase reverse transcriptase	Homo sapiens	155-160
25590866-0	2015	Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells.	cordycepin	0-10	tumor protein p53	Homo sapiens	95-98
25595313-7	2015	Moreover, we found that cordycepin, a known inhibitor of VSMC migration, caused significant downregulation of MMP2, 9, and 13 expression in PDGF-treated RAoSMCs.	cordycepin	24-34	matrix metallopeptidase 2	Rattus norvegicus	110-114
25874211-6	2015	The beneficial effects of cordycepin on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, and CTX level.	cordycepin	26-36	acid phosphatase 5, tartrate resistant	Rattus norvegicus	127-131
25590866-6	2015	Cordycepin also blocks MAPK pathway by inhibiting the phosphorylation of ERK1/2, and thus sensitizes the apoptosis.	cordycepin	0-10	mitogen-activated protein kinase 3	Homo sapiens	23-27
25590866-6	2015	Cordycepin also blocks MAPK pathway by inhibiting the phosphorylation of ERK1/2, and thus sensitizes the apoptosis.	cordycepin	0-10	mitogen-activated protein kinase 3	Homo sapiens	73-79
25417131-4	2015	Our study demonstrated that cordycepin inhibited OVA-induced increases in eosinophil count; IL-17A levels were recovered and increased IL-10 levels in bronchoalveolar lavage fluid.	cordycepin	28-38	interleukin 10	Mus musculus	135-140
25342887-4	2014	Our data demonstrated that cordycepin suppressed production of proinflammatory mediators such as nitric oxide (NO) and prostaglandin E2 by inhibiting inducible NO synthase and cyclooxygenase-2 gene expression.	cordycepin	27-37	prostaglandin-endoperoxide synthase 2	Mus musculus	176-192
25775775-7	2014	In vitro, cordycepin induced the high expression of p-elF2alpha, and inhibited the expressions of p-Smad2/3, Col I and Col IV induced by TGF-beta in NRK-52E cells.	cordycepin	10-20	SMAD family member 3	Rattus norvegicus	100-107
25775775-7	2014	In vitro, cordycepin induced the high expression of p-elF2alpha, and inhibited the expressions of p-Smad2/3, Col I and Col IV induced by TGF-beta in NRK-52E cells.	cordycepin	10-20	transforming growth factor, beta 1	Rattus norvegicus	137-145
25868853-0	2015	Cordycepin (3"-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b.	cordycepin	0-10	high mobility group AT-hook 2	Homo sapiens	42-47
25868853-0	2015	Cordycepin (3"-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b.	cordycepin	0-10	twist family bHLH transcription factor 1	Homo sapiens	49-55
25868853-0	2015	Cordycepin (3"-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b.	cordycepin	0-10	zinc finger E-box binding homeobox 1	Homo sapiens	60-64
25868853-0	2015	Cordycepin (3"-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b.	cordycepin	0-10	microRNA 33b	Homo sapiens	121-128
25868853-0	2015	Cordycepin (3"-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b.	cordycepin	12-29	high mobility group AT-hook 2	Homo sapiens	42-47
25868853-0	2015	Cordycepin (3"-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b.	cordycepin	12-29	twist family bHLH transcription factor 1	Homo sapiens	49-55
25868853-0	2015	Cordycepin (3"-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b.	cordycepin	12-29	zinc finger E-box binding homeobox 1	Homo sapiens	60-64
25868853-0	2015	Cordycepin (3"-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b.	cordycepin	12-29	microRNA 33b	Homo sapiens	121-128
25868853-5	2015	Cordycepin-mediated miR-33b expression was dependent on LXR-RXR heterodimer activation.	cordycepin	0-10	microRNA 33b	Homo sapiens	20-27
25868853-5	2015	Cordycepin-mediated miR-33b expression was dependent on LXR-RXR heterodimer activation.	cordycepin	0-10	retinoid X receptor alpha	Homo sapiens	60-63
23543357-5	2014	In cellular mechanism study, co-treatment of cordycepin and cisplatin induced more stress-activated protein kinase/Jun terminal kinase (JNK), the expressions of caspase-7, and the cleavage of poly ADP-ribose polymerase (PARP) as compared to cisplatin or cordycepin alone treatment (P <0.05).	cordycepin	45-55	mitogen-activated protein kinase 8	Homo sapiens	136-139
25400736-0	2014	Cordycepin modulates inflammatory and catabolic gene expression in interleukin-1beta-induced human chondrocytes from advanced-stage osteoarthritis: an in vitro study.	cordycepin	0-10	interleukin 1 beta	Homo sapiens	67-84
25400736-3	2014	In the present study, we examined the inhibitory effects of cordycepin on interleukin-1 beta (IL-1beta)-induced glycosaminoglycan (GAG) release, nitric oxide production as well as gene expressions of inflammatory and catabolic mediators in human cartilage and chondrocytes.	cordycepin	60-70	interleukin 1 beta	Homo sapiens	74-92
25400736-3	2014	In the present study, we examined the inhibitory effects of cordycepin on interleukin-1 beta (IL-1beta)-induced glycosaminoglycan (GAG) release, nitric oxide production as well as gene expressions of inflammatory and catabolic mediators in human cartilage and chondrocytes.	cordycepin	60-70	interleukin 1 beta	Homo sapiens	94-102
25400736-8	2014	We found that cordycepin suppressed IL-1beta-stimulated GAG release.	cordycepin	14-24	interleukin 1 beta	Homo sapiens	36-44
25400736-10	2014	In addition, cordycepin inhibited IL-1beta-induced COX-2 and iNOS expression at the transcript level as well as blocked NO production.	cordycepin	13-23	interleukin 1 beta	Homo sapiens	34-42
25400736-10	2014	In addition, cordycepin inhibited IL-1beta-induced COX-2 and iNOS expression at the transcript level as well as blocked NO production.	cordycepin	13-23	nitric oxide synthase 2	Homo sapiens	61-65
23543357-2	2014	METHODS: The influences of cisplatin (2.5 mug/mL) and/or cordycepin treatment (10 or 100 mumol/L) to human OC3 oral cancer cell line were investigated by morphological observation for cell death appearance, methylthiazoletetrazolium (MTT) assay for cell viability, flow cytometry assay for cell apoptosis, and Western blotting for apoptotic protein expressions.	cordycepin	57-67	one cut homeobox 3	Homo sapiens	107-110
23543357-5	2014	In cellular mechanism study, co-treatment of cordycepin and cisplatin induced more stress-activated protein kinase/Jun terminal kinase (JNK), the expressions of caspase-7, and the cleavage of poly ADP-ribose polymerase (PARP) as compared to cisplatin or cordycepin alone treatment (P <0.05).	cordycepin	45-55	caspase 7	Homo sapiens	161-170
23543357-3	2014	RESULTS: Data demonstrated that co-administration of cisplatin (2.5 mug/mL) and cordycepin (10 or 100 mumol/L) resulted in the enhancement of OC3 cell apoptosis compared to cisplatin or cordycepin alone treatment (24 h), respectively (P <0.05).	cordycepin	80-90	one cut homeobox 3	Homo sapiens	142-145
23543357-3	2014	RESULTS: Data demonstrated that co-administration of cisplatin (2.5 mug/mL) and cordycepin (10 or 100 mumol/L) resulted in the enhancement of OC3 cell apoptosis compared to cisplatin or cordycepin alone treatment (24 h), respectively (P <0.05).	cordycepin	186-196	one cut homeobox 3	Homo sapiens	142-145
23543357-5	2014	In cellular mechanism study, co-treatment of cordycepin and cisplatin induced more stress-activated protein kinase/Jun terminal kinase (JNK), the expressions of caspase-7, and the cleavage of poly ADP-ribose polymerase (PARP) as compared to cisplatin or cordycepin alone treatment (P <0.05).	cordycepin	45-55	poly(ADP-ribose) polymerase 1	Homo sapiens	192-218
23543357-5	2014	In cellular mechanism study, co-treatment of cordycepin and cisplatin induced more stress-activated protein kinase/Jun terminal kinase (JNK), the expressions of caspase-7, and the cleavage of poly ADP-ribose polymerase (PARP) as compared to cisplatin or cordycepin alone treatment (P <0.05).	cordycepin	45-55	poly(ADP-ribose) polymerase 1	Homo sapiens	220-224
23543357-6	2014	CONCLUSION: Cisplatin and cordycepin possess synergistically apoptotic effect through the activation of JNK/caspase-7/PARP pathway in human OC3 oral cancer cell line.	cordycepin	26-36	mitogen-activated protein kinase 8	Homo sapiens	104-107
23543357-6	2014	CONCLUSION: Cisplatin and cordycepin possess synergistically apoptotic effect through the activation of JNK/caspase-7/PARP pathway in human OC3 oral cancer cell line.	cordycepin	26-36	caspase 7	Homo sapiens	108-117
23543357-6	2014	CONCLUSION: Cisplatin and cordycepin possess synergistically apoptotic effect through the activation of JNK/caspase-7/PARP pathway in human OC3 oral cancer cell line.	cordycepin	26-36	poly(ADP-ribose) polymerase 1	Homo sapiens	118-122
23543357-6	2014	CONCLUSION: Cisplatin and cordycepin possess synergistically apoptotic effect through the activation of JNK/caspase-7/PARP pathway in human OC3 oral cancer cell line.	cordycepin	26-36	one cut homeobox 3	Homo sapiens	140-143
25090123-6	2014	Cordycepin-induced apoptosis was observed using an Annexin V/propidium iodide (PI) double-staining assay, and the mitochondrial membrane potential (DeltaPsim) decreased in a dose-dependent manner.	cordycepin	0-10	annexin A5	Homo sapiens	51-60
25046749-4	2014	We found that cordycepin inhibited mTOR complex 1 (mTORC1) activation and down-regulated multiple drug resistant (MDR)/hypoxia-inducible factor 1alpha (HIF-1alpha) expression through activating of AMP-activated protein kinase (AMPK) signaling in gallbladder cancer GBC-SD cells.	cordycepin	14-24	CREB regulated transcription coactivator 1	Mus musculus	51-57
25046749-4	2014	We found that cordycepin inhibited mTOR complex 1 (mTORC1) activation and down-regulated multiple drug resistant (MDR)/hypoxia-inducible factor 1alpha (HIF-1alpha) expression through activating of AMP-activated protein kinase (AMPK) signaling in gallbladder cancer GBC-SD cells.	cordycepin	14-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-150
25046749-4	2014	We found that cordycepin inhibited mTOR complex 1 (mTORC1) activation and down-regulated multiple drug resistant (MDR)/hypoxia-inducible factor 1alpha (HIF-1alpha) expression through activating of AMP-activated protein kinase (AMPK) signaling in gallbladder cancer GBC-SD cells.	cordycepin	14-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-162
25046749-4	2014	We found that cordycepin inhibited mTOR complex 1 (mTORC1) activation and down-regulated multiple drug resistant (MDR)/hypoxia-inducible factor 1alpha (HIF-1alpha) expression through activating of AMP-activated protein kinase (AMPK) signaling in gallbladder cancer GBC-SD cells.	cordycepin	14-24	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	197-225
25046749-4	2014	We found that cordycepin inhibited mTOR complex 1 (mTORC1) activation and down-regulated multiple drug resistant (MDR)/hypoxia-inducible factor 1alpha (HIF-1alpha) expression through activating of AMP-activated protein kinase (AMPK) signaling in gallbladder cancer GBC-SD cells.	cordycepin	14-24	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	227-231
25046749-7	2014	In summary, cordycepin induces growth inhibition and apoptosis in gallbladder cancer cells via activating AMPK signaling.	cordycepin	12-22	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	106-110
24704558-0	2014	Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway.	cordycepin	0-10	caspase 7	Rattus norvegicus	86-95
25007068-0	2014	Cordycepin inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha production via activating amp-activated protein kinase (AMPK) signaling.	cordycepin	0-10	tumor necrosis factor	Homo sapiens	76-86
25007068-4	2014	Meanwhile, cordycepin alleviated TNFalpha production in KD patients" PBMCs.	cordycepin	11-21	tumor necrosis factor	Homo sapiens	33-41
25007068-9	2014	Further, we found that cordycepin inhibited reactive oxygen species (ROS) production and nuclear factor kappa B (NF-kappaB) activation in LPS-stimulate RAW 264.7 cells or healthy controls" PBMCs.	cordycepin	23-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	89-111
25007068-9	2014	Further, we found that cordycepin inhibited reactive oxygen species (ROS) production and nuclear factor kappa B (NF-kappaB) activation in LPS-stimulate RAW 264.7 cells or healthy controls" PBMCs.	cordycepin	23-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
24973666-5	2014	Cordycepin treatment caused a dose-dependent increase of pro-apoptotic Bax and decrease of anti-apoptotic Bcl-2, triggering collapse of the mitochondrial membrane potential and activation of caspase-9 and -3.	cordycepin	0-10	BCL2 associated X, apoptosis regulator	Homo sapiens	71-74
24973666-5	2014	Cordycepin treatment caused a dose-dependent increase of pro-apoptotic Bax and decrease of anti-apoptotic Bcl-2, triggering collapse of the mitochondrial membrane potential and activation of caspase-9 and -3.	cordycepin	0-10	BCL2 apoptosis regulator	Homo sapiens	106-111
24973666-5	2014	Cordycepin treatment caused a dose-dependent increase of pro-apoptotic Bax and decrease of anti-apoptotic Bcl-2, triggering collapse of the mitochondrial membrane potential and activation of caspase-9 and -3.	cordycepin	0-10	caspase 9	Homo sapiens	191-207
24973666-6	2014	Cordycepin-induced cell death was also associated with induction of Fas and death receptor 5, activation of caspase-8, and truncation of Bid (tBid), suggesting that tBid might serve to connect activation of both the mitochondrial-mediated intrinsic and death receptor-mediated extrinsic apoptotic pathways.	cordycepin	0-10	TNF receptor superfamily member 10b	Homo sapiens	76-92
24973666-6	2014	Cordycepin-induced cell death was also associated with induction of Fas and death receptor 5, activation of caspase-8, and truncation of Bid (tBid), suggesting that tBid might serve to connect activation of both the mitochondrial-mediated intrinsic and death receptor-mediated extrinsic apoptotic pathways.	cordycepin	0-10	caspase 8	Homo sapiens	108-117
24973666-6	2014	Cordycepin-induced cell death was also associated with induction of Fas and death receptor 5, activation of caspase-8, and truncation of Bid (tBid), suggesting that tBid might serve to connect activation of both the mitochondrial-mediated intrinsic and death receptor-mediated extrinsic apoptotic pathways.	cordycepin	0-10	BH3 interacting domain death agonist	Homo sapiens	137-140
24973666-7	2014	The general caspase inhibitor, z-VAD-fmk, completely abolished cordycepin-induced cell death, demonstrating that cordycepin-induced apoptosis was dependent on the activation of caspases.	cordycepin	63-73	caspase 8	Homo sapiens	177-185
24973666-7	2014	The general caspase inhibitor, z-VAD-fmk, completely abolished cordycepin-induced cell death, demonstrating that cordycepin-induced apoptosis was dependent on the activation of caspases.	cordycepin	113-123	caspase 8	Homo sapiens	177-185
24973666-8	2014	Cordycepin also stimulated autophagy, which was evidenced by an increase in microtubule-associated protein light chain-3 (LC3) puncta, accumulation of LC3-II, and elevation of autophagic flux; however, blockage of autophagic flux by the autophagic inhibitor bafilomycin A1 promoted cell-switching to apoptotic cell death.	cordycepin	0-10	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	122-125
24973666-8	2014	Cordycepin also stimulated autophagy, which was evidenced by an increase in microtubule-associated protein light chain-3 (LC3) puncta, accumulation of LC3-II, and elevation of autophagic flux; however, blockage of autophagic flux by the autophagic inhibitor bafilomycin A1 promoted cell-switching to apoptotic cell death.	cordycepin	0-10	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	151-154
24346509-11	2014	Pretreatment with cordycepin attenuated IL-1beta-induced activation of NF-kappaB by suppressing degradation of its inhibitory protein nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaB-alpha) in the cytoplasm.	cordycepin	18-28	interleukin 1 beta	Homo sapiens	40-48
24346509-11	2014	Pretreatment with cordycepin attenuated IL-1beta-induced activation of NF-kappaB by suppressing degradation of its inhibitory protein nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaB-alpha) in the cytoplasm.	cordycepin	18-28	nuclear factor kappa B subunit 1	Homo sapiens	71-80
24346509-11	2014	Pretreatment with cordycepin attenuated IL-1beta-induced activation of NF-kappaB by suppressing degradation of its inhibitory protein nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaB-alpha) in the cytoplasm.	cordycepin	18-28	NFKB inhibitor alpha	Homo sapiens	134-217
24346509-11	2014	Pretreatment with cordycepin attenuated IL-1beta-induced activation of NF-kappaB by suppressing degradation of its inhibitory protein nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaB-alpha) in the cytoplasm.	cordycepin	18-28	NFKB inhibitor alpha	Homo sapiens	219-232
24704558-0	2014	Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway.	cordycepin	0-10	adenosine A2a receptor	Rattus norvegicus	60-81
24704558-0	2014	Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway.	cordycepin	0-10	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	82-85
24486958-4	2014	Cordycepin inhibits CHOP and Bax expressions, as well as p-ERK, p-JNK, and p-p38, all of which are involved in oxidative or ER stress-induced apoptosis.	cordycepin	0-10	DNA-damage inducible transcript 3	Mus musculus	20-24
24486958-4	2014	Cordycepin inhibits CHOP and Bax expressions, as well as p-ERK, p-JNK, and p-p38, all of which are involved in oxidative or ER stress-induced apoptosis.	cordycepin	0-10	BCL2-associated X protein	Mus musculus	29-32
23926438-6	2013	Furthermore, cordycepin or cisplatin induced caspase-8, caspase-9, caspase-3, and poly adenosine diphosphate-ribose polymerase protein cleavages, and stimulated c-Jun NH2-terminal kinase, extracellular signal-regulated kinase, and p38 protein phosphorylations.	cordycepin	13-23	mitogen-activated protein kinase 14	Homo sapiens	231-234
24286368-5	2014	Cordycepin-induced AMPK activation was not accompanied by changes in either the intracellular levels of AMP or the AMP/ATP ratio, nor was it influenced by calmodulin-dependent protein kinase kinase (CaMKK) inhibition; however, this activation was significantly suppressed by liver kinase B1 (LKB1) knockdown.	cordycepin	0-10	serine/threonine kinase 11	Homo sapiens	275-290
24286368-5	2014	Cordycepin-induced AMPK activation was not accompanied by changes in either the intracellular levels of AMP or the AMP/ATP ratio, nor was it influenced by calmodulin-dependent protein kinase kinase (CaMKK) inhibition; however, this activation was significantly suppressed by liver kinase B1 (LKB1) knockdown.	cordycepin	0-10	serine/threonine kinase 11	Homo sapiens	292-296
23855336-0	2014	Cordycepin suppresses integrin/FAK signaling and epithelial-mesenchymal transition in hepatocellular carcinoma.	cordycepin	0-10	protein tyrosine kinase 2	Homo sapiens	31-34
24292575-4	2013	Control mice not administered cordycepin exhibited higher serum levels of alanine aminotransferase (ALT) due to damage to the liver by metastasized B16-F0 cells from the spleen, and survival times ranged from 17 to 22 days after tumor inoculation.	cordycepin	30-40	glutamic pyruvic transaminase, soluble	Mus musculus	74-98
24292575-4	2013	Control mice not administered cordycepin exhibited higher serum levels of alanine aminotransferase (ALT) due to damage to the liver by metastasized B16-F0 cells from the spleen, and survival times ranged from 17 to 22 days after tumor inoculation.	cordycepin	30-40	glutamic pyruvic transaminase, soluble	Mus musculus	100-103
24292575-5	2013	Cordycepin was intraperitoneally administered to mice, and resulted in significantly lower serum ALT levels and longer survival times than those observed in control mice.	cordycepin	0-10	glutamic pyruvic transaminase, soluble	Mus musculus	97-100
23941773-2	2013	However, cordycepin induced apoptosis through the DR3 pathway in human colon cancer cells has not been studied.	cordycepin	9-19	TNF receptor superfamily member 25	Homo sapiens	50-53
23941773-6	2013	Cordycepin induced apoptosis in HT-29 cells in a dose-dependent manner as detected by Hoechst and Annexin V-FITC staining.	cordycepin	0-10	annexin A5	Homo sapiens	98-107
23828231-0	2013	Cordycepin increases sensitivity of Hep3B human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by inactivating the JNK signaling pathway.	cordycepin	0-10	TNF superfamily member 10	Homo sapiens	82-87
23828231-0	2013	Cordycepin increases sensitivity of Hep3B human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by inactivating the JNK signaling pathway.	cordycepin	0-10	mitogen-activated protein kinase 8	Homo sapiens	127-130
23828231-3	2013	In the present study, we demonstrated that treatment of cordycepin sensitized TRAIL-resistant Hep3B human hepatocellular carcinoma cells to TRAIL-mediated apoptosis as evidenced by formation of apoptotic bodies, chromatin condensation and accumulation of cells in the sub-G1 phase.	cordycepin	56-66	TNF superfamily member 10	Homo sapiens	78-83
23828231-3	2013	In the present study, we demonstrated that treatment of cordycepin sensitized TRAIL-resistant Hep3B human hepatocellular carcinoma cells to TRAIL-mediated apoptosis as evidenced by formation of apoptotic bodies, chromatin condensation and accumulation of cells in the sub-G1 phase.	cordycepin	56-66	TNF superfamily member 10	Homo sapiens	140-145
23828231-5	2013	In addition, cordycepin treatment also inhibited activation of c-Jun N-terminal kinase (JNK).	cordycepin	13-23	mitogen-activated protein kinase 8	Homo sapiens	63-86
23828231-5	2013	In addition, cordycepin treatment also inhibited activation of c-Jun N-terminal kinase (JNK).	cordycepin	13-23	mitogen-activated protein kinase 8	Homo sapiens	88-91
23828231-7	2013	Taken together, these results indicate that JNK acts as a key regulator of apoptosis in response to combined treatment with cordycepin and TRAIL in human hepatocellular carcinoma Hep3B cells.	cordycepin	124-134	mitogen-activated protein kinase 8	Homo sapiens	44-47
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	29-39	eukaryotic translation initiation factor 2A	Homo sapiens	180-189
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	29-39	eukaryotic translation initiation factor 2A	Homo sapiens	180-189
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	29-39	eukaryotic translation initiation factor 2A	Homo sapiens	180-189
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	142-152	eukaryotic translation initiation factor 2A	Homo sapiens	70-117
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	142-152	eukaryotic translation initiation factor 2A	Homo sapiens	119-128
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	142-152	eukaryotic translation initiation factor 2A	Homo sapiens	180-189
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	142-152	eukaryotic translation initiation factor 2A	Homo sapiens	180-189
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	142-152	eukaryotic translation initiation factor 2A	Homo sapiens	180-189
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	142-152	eukaryotic translation initiation factor 2A	Homo sapiens	70-117
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	142-152	eukaryotic translation initiation factor 2A	Homo sapiens	119-128
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	142-152	eukaryotic translation initiation factor 2A	Homo sapiens	180-189
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	142-152	eukaryotic translation initiation factor 2A	Homo sapiens	180-189
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	142-152	eukaryotic translation initiation factor 2A	Homo sapiens	180-189
23926438-6	2013	Furthermore, cordycepin or cisplatin induced caspase-8, caspase-9, caspase-3, and poly adenosine diphosphate-ribose polymerase protein cleavages, and stimulated c-Jun NH2-terminal kinase, extracellular signal-regulated kinase, and p38 protein phosphorylations.	cordycepin	13-23	caspase 8	Homo sapiens	45-54
23926438-6	2013	Furthermore, cordycepin or cisplatin induced caspase-8, caspase-9, caspase-3, and poly adenosine diphosphate-ribose polymerase protein cleavages, and stimulated c-Jun NH2-terminal kinase, extracellular signal-regulated kinase, and p38 protein phosphorylations.	cordycepin	13-23	caspase 9	Homo sapiens	56-65
23926438-6	2013	Furthermore, cordycepin or cisplatin induced caspase-8, caspase-9, caspase-3, and poly adenosine diphosphate-ribose polymerase protein cleavages, and stimulated c-Jun NH2-terminal kinase, extracellular signal-regulated kinase, and p38 protein phosphorylations.	cordycepin	13-23	caspase 3	Homo sapiens	67-76
23933282-0	2013	Influence of treatment with 3"-deoxyadenosine associated deoxycoformycin on hematological parameters and activity of adenosine deaminase in infected mice with Trypanosoma evansi.	cordycepin	28-45	adenosine deaminase	Mus musculus	117-136
23933282-1	2013	This study aimed to verify the effect of 3"-deoxyadenosine and deoxycoformycin on hematologic parameters and adenosine deaminase (ADA) activity in plasma and brain of mice infected with Trypanosoma evansi.	cordycepin	41-58	adenosine deaminase	Mus musculus	109-128
24086728-9	2013	Cordycepin-reduced beta-catenin stability was restored by the addition of a pharmacological inhibitor of GSK-3beta, indicating that cordycepin-suppressed beta-catenin stability is mediated by the activation of GSK-3beta.	cordycepin	132-142	catenin beta 1	Homo sapiens	19-31
24086728-9	2013	Cordycepin-reduced beta-catenin stability was restored by the addition of a pharmacological inhibitor of GSK-3beta, indicating that cordycepin-suppressed beta-catenin stability is mediated by the activation of GSK-3beta.	cordycepin	132-142	glycogen synthase kinase 3 beta	Homo sapiens	105-114
24086728-9	2013	Cordycepin-reduced beta-catenin stability was restored by the addition of a pharmacological inhibitor of GSK-3beta, indicating that cordycepin-suppressed beta-catenin stability is mediated by the activation of GSK-3beta.	cordycepin	132-142	catenin beta 1	Homo sapiens	154-166
24086728-9	2013	Cordycepin-reduced beta-catenin stability was restored by the addition of a pharmacological inhibitor of GSK-3beta, indicating that cordycepin-suppressed beta-catenin stability is mediated by the activation of GSK-3beta.	cordycepin	132-142	glycogen synthase kinase 3 beta	Homo sapiens	210-219
24086728-10	2013	Furthermore, cordycepin abolished the effect of Wnt3a-induced beta-catenin in leukemia cells.	cordycepin	13-23	Wnt family member 3A	Homo sapiens	48-53
24086728-10	2013	Furthermore, cordycepin abolished the effect of Wnt3a-induced beta-catenin in leukemia cells.	cordycepin	13-23	catenin beta 1	Homo sapiens	62-74
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	29-39	eukaryotic translation initiation factor 2A	Homo sapiens	70-117
23690541-6	2013	The antisenescence effect of cordycepin was mediated by activation of eukaryotic translation initiation factor 2alpha (eIF2alpha) because (1) cordycepin induced phosphorylation of eIF2alpha, (2) selective activation of eIF2alpha mimicked the suppressive effect of cordycepin on senescence, and (3) functional knockdown of eIF2alpha reversed the effect of cordycepin.	cordycepin	29-39	eukaryotic translation initiation factor 2A	Homo sapiens	119-128
23611488-7	2013	Other bioactive compounds, such as cordycepin and zhankuic acid A, have been demonstrated to reduce the expression of MMP-9, cyclin E, cyclin D1 and to increase the expression of p21, p27.	cordycepin	35-45	matrix metallopeptidase 9	Mus musculus	118-123
23611488-7	2013	Other bioactive compounds, such as cordycepin and zhankuic acid A, have been demonstrated to reduce the expression of MMP-9, cyclin E, cyclin D1 and to increase the expression of p21, p27.	cordycepin	35-45	cyclin D1	Mus musculus	135-144
23611488-7	2013	Other bioactive compounds, such as cordycepin and zhankuic acid A, have been demonstrated to reduce the expression of MMP-9, cyclin E, cyclin D1 and to increase the expression of p21, p27.	cordycepin	35-45	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	179-182
23611488-7	2013	Other bioactive compounds, such as cordycepin and zhankuic acid A, have been demonstrated to reduce the expression of MMP-9, cyclin E, cyclin D1 and to increase the expression of p21, p27.	cordycepin	35-45	cyclin-dependent kinase inhibitor 1B	Mus musculus	184-187
23361035-1	2013	The aim of this study was to evaluate the anti-trypanosomal effect of treatment with 3"-deoxyadenosine (cordycepin) combined with deoxycoformycin (pentostatin: inhibitor of the enzyme adenosine deaminase) in vitro by using mice experimentally infected with Trypanosoma evansi.	cordycepin	85-102	adenosine deaminase	Mus musculus	184-203
23361035-1	2013	The aim of this study was to evaluate the anti-trypanosomal effect of treatment with 3"-deoxyadenosine (cordycepin) combined with deoxycoformycin (pentostatin: inhibitor of the enzyme adenosine deaminase) in vitro by using mice experimentally infected with Trypanosoma evansi.	cordycepin	104-114	adenosine deaminase	Mus musculus	184-203
23102662-0	2012	Cordycepin suppresses TNF-alpha-induced NF-kappaB activation by reducing p65 transcriptional activity, inhibiting IkappaBalpha phosphorylation, and blocking IKKgamma ubiquitination.	cordycepin	0-10	tumor necrosis factor	Homo sapiens	22-31
24021789-6	2013	RESULTS: High-concentration (200 mumol/L) treatments of both cordyceps acid and cordycepin significantly inhibited the LPS-induced up-regulation of MCP-1 transcription and secretion (mRNA: 2.07 +/- 0.29 vs. 3.35 +/- 0.26, t = 15.90 and 1.15 +/- 0.23 vs. 4.17 +/- 0.61, t = 8.93; protein: 1.88 +/- 0.06 vs. 2.33 +/- 0.06, t = 10.39 and 1.47 +/- 0.25 vs. 1.97 +/- 0.04, t = 4.60; all P less than 0.05).	cordycepin	80-90	chemokine (C-C motif) ligand 2	Mus musculus	148-153
24021789-7	2013	All concentrations of cordyceps acid and cordycepin inhibited the TGFb1-induced up-regulation of collagen type I and a-SMA protein expression.	cordycepin	41-51	transforming growth factor, beta 1	Mus musculus	66-71
24021789-7	2013	All concentrations of cordyceps acid and cordycepin inhibited the TGFb1-induced up-regulation of collagen type I and a-SMA protein expression.	cordycepin	41-51	actin alpha 2, smooth muscle, aorta	Mus musculus	117-122
24021789-9	2013	CONCLUSION: Cordyceps acid and cordycepin ameliorate the LPS-induced inflammatory phenotype and TGFb1-induced fibrogenic response of cultured HSCs.	cordycepin	31-41	transforming growth factor, beta 1	Mus musculus	96-101
23292300-5	2013	Apoptosis induction of PC-3 cells by cordycepin showed correlation with proteolytic activation of caspase-3 and -9, but not caspase-8, and concomitant degradation of poly (ADP-ribose) polymerases, collapse of the mitochondrial membrane potential (MMP).	cordycepin	37-47	caspase 3	Homo sapiens	98-114
23292300-6	2013	In addition, cordycepin treatment resulted in an increase of the Bax/Bcl-2 (or Bcl-xL) ratio, downregulation of inhibitor of apoptosis protein (IAP) family members, Bax conformational changes, and release of cytochrome c from the mitochondria to the cytosol.	cordycepin	13-23	BCL2 associated X, apoptosis regulator	Homo sapiens	65-68
23292300-6	2013	In addition, cordycepin treatment resulted in an increase of the Bax/Bcl-2 (or Bcl-xL) ratio, downregulation of inhibitor of apoptosis protein (IAP) family members, Bax conformational changes, and release of cytochrome c from the mitochondria to the cytosol.	cordycepin	13-23	BCL2 apoptosis regulator	Homo sapiens	69-74
23292300-6	2013	In addition, cordycepin treatment resulted in an increase of the Bax/Bcl-2 (or Bcl-xL) ratio, downregulation of inhibitor of apoptosis protein (IAP) family members, Bax conformational changes, and release of cytochrome c from the mitochondria to the cytosol.	cordycepin	13-23	BCL2 like 1	Homo sapiens	79-85
23292300-6	2013	In addition, cordycepin treatment resulted in an increase of the Bax/Bcl-2 (or Bcl-xL) ratio, downregulation of inhibitor of apoptosis protein (IAP) family members, Bax conformational changes, and release of cytochrome c from the mitochondria to the cytosol.	cordycepin	13-23	magnesium transporter 1	Homo sapiens	112-142
23292300-6	2013	In addition, cordycepin treatment resulted in an increase of the Bax/Bcl-2 (or Bcl-xL) ratio, downregulation of inhibitor of apoptosis protein (IAP) family members, Bax conformational changes, and release of cytochrome c from the mitochondria to the cytosol.	cordycepin	13-23	magnesium transporter 1	Homo sapiens	144-147
23292300-6	2013	In addition, cordycepin treatment resulted in an increase of the Bax/Bcl-2 (or Bcl-xL) ratio, downregulation of inhibitor of apoptosis protein (IAP) family members, Bax conformational changes, and release of cytochrome c from the mitochondria to the cytosol.	cordycepin	13-23	BCL2 associated X, apoptosis regulator	Homo sapiens	165-168
23292300-6	2013	In addition, cordycepin treatment resulted in an increase of the Bax/Bcl-2 (or Bcl-xL) ratio, downregulation of inhibitor of apoptosis protein (IAP) family members, Bax conformational changes, and release of cytochrome c from the mitochondria to the cytosol.	cordycepin	13-23	cytochrome c, somatic	Homo sapiens	208-220
23000874-7	2012	In addition, the levels of MDA, AST, ALT, urea and creatinine became reduced upon administration of cordycepin to aged rats.	cordycepin	100-110	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	32-35
23102662-0	2012	Cordycepin suppresses TNF-alpha-induced NF-kappaB activation by reducing p65 transcriptional activity, inhibiting IkappaBalpha phosphorylation, and blocking IKKgamma ubiquitination.	cordycepin	0-10	nuclear factor kappa B subunit 1	Homo sapiens	40-49
23102662-0	2012	Cordycepin suppresses TNF-alpha-induced NF-kappaB activation by reducing p65 transcriptional activity, inhibiting IkappaBalpha phosphorylation, and blocking IKKgamma ubiquitination.	cordycepin	0-10	RELA proto-oncogene, NF-kB subunit	Homo sapiens	73-76
23102662-0	2012	Cordycepin suppresses TNF-alpha-induced NF-kappaB activation by reducing p65 transcriptional activity, inhibiting IkappaBalpha phosphorylation, and blocking IKKgamma ubiquitination.	cordycepin	0-10	NFKB inhibitor alpha	Homo sapiens	114-126
23102662-0	2012	Cordycepin suppresses TNF-alpha-induced NF-kappaB activation by reducing p65 transcriptional activity, inhibiting IkappaBalpha phosphorylation, and blocking IKKgamma ubiquitination.	cordycepin	0-10	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	157-165
23102662-7	2012	In conclusion, cordycepin effectively inhibits NF-kappaB signaling through suppressing the activities of NF-kappaB, IkappaB and IKK.	cordycepin	15-25	nuclear factor kappa B subunit 1	Homo sapiens	47-56
23102662-7	2012	In conclusion, cordycepin effectively inhibits NF-kappaB signaling through suppressing the activities of NF-kappaB, IkappaB and IKK.	cordycepin	15-25	nuclear factor kappa B subunit 1	Homo sapiens	105-114
23239437-0	2012	Triacetyl-3-hydroxyphenyladenosine, a derivative of cordycepin, attenuates atherosclerosis in apolipoprotein E-knockout mice.	cordycepin	52-62	apolipoprotein E	Mus musculus	94-110
22512531-10	2012	Moreover, cordycepin could stimulate the phosphorylation of PKC, extracellular signal-regulated kinase 1/2 (ERK1/2), and c-Jun N-terminal kinase (c-JNK), but not p38, in MA-10 cells.	cordycepin	10-20	mitogen-activated protein kinase 3	Mus musculus	65-106
22519596-0	2012	Cordycepin as a sensitizer to tumour necrosis factor (TNF)-alpha-induced apoptosis through eukaryotic translation initiation factor 2alpha (eIF2alpha)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-kappaB.	cordycepin	0-10	tumor necrosis factor	Homo sapiens	30-64
22519596-0	2012	Cordycepin as a sensitizer to tumour necrosis factor (TNF)-alpha-induced apoptosis through eukaryotic translation initiation factor 2alpha (eIF2alpha)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-kappaB.	cordycepin	0-10	eukaryotic translation initiation factor 2A	Homo sapiens	91-138
22519596-0	2012	Cordycepin as a sensitizer to tumour necrosis factor (TNF)-alpha-induced apoptosis through eukaryotic translation initiation factor 2alpha (eIF2alpha)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-kappaB.	cordycepin	0-10	eukaryotic translation initiation factor 2A	Homo sapiens	140-149
22519596-0	2012	Cordycepin as a sensitizer to tumour necrosis factor (TNF)-alpha-induced apoptosis through eukaryotic translation initiation factor 2alpha (eIF2alpha)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-kappaB.	cordycepin	0-10	CREB regulated transcription coactivator 1	Mus musculus	197-203
22519596-0	2012	Cordycepin as a sensitizer to tumour necrosis factor (TNF)-alpha-induced apoptosis through eukaryotic translation initiation factor 2alpha (eIF2alpha)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-kappaB.	cordycepin	0-10	nuclear factor kappa B subunit 1	Homo sapiens	228-254
22519596-7	2012	We found that cordycepin had the potential to phosphorylate eukaryotic translation initiation factor 2alpha (eIF2alpha) and that activation of eIF2alpha mimicked the suppressive effect of cordycepin on the NF-kappaB pathway.	cordycepin	14-24	eukaryotic translation initiation factor 2A	Homo sapiens	60-107
22519596-7	2012	We found that cordycepin had the potential to phosphorylate eukaryotic translation initiation factor 2alpha (eIF2alpha) and that activation of eIF2alpha mimicked the suppressive effect of cordycepin on the NF-kappaB pathway.	cordycepin	14-24	eukaryotic translation initiation factor 2A	Homo sapiens	109-118
22519596-7	2012	We found that cordycepin had the potential to phosphorylate eukaryotic translation initiation factor 2alpha (eIF2alpha) and that activation of eIF2alpha mimicked the suppressive effect of cordycepin on the NF-kappaB pathway.	cordycepin	188-198	eukaryotic translation initiation factor 2A	Homo sapiens	143-152
22512531-10	2012	Moreover, cordycepin could stimulate the phosphorylation of PKC, extracellular signal-regulated kinase 1/2 (ERK1/2), and c-Jun N-terminal kinase (c-JNK), but not p38, in MA-10 cells.	cordycepin	10-20	mitogen-activated protein kinase 3	Mus musculus	108-114
22512531-12	2012	In conclusion, cordycepin stimulated intracellular PLC/PKC and MAPK signal transduction pathways to induce steroidogenesis and cell death in MA-10 mouse Leydig tumor cells.	cordycepin	15-25	mitogen-activated protein kinase 1	Mus musculus	63-67
22246470-6	2012	Furthermore, cordycepin             inhibited the expression and activity of matrix metalloproteinase (MMP)-2 and             MMP-9, and simultaneously increased levels of tissue inhibitor of metalloproteinase             (TIMP)-1 and TIMP-2.	cordycepin	13-23	matrix metallopeptidase 2	Homo sapiens	77-109
22246470-6	2012	Furthermore, cordycepin             inhibited the expression and activity of matrix metalloproteinase (MMP)-2 and             MMP-9, and simultaneously increased levels of tissue inhibitor of metalloproteinase             (TIMP)-1 and TIMP-2.	cordycepin	13-23	matrix metallopeptidase 9	Homo sapiens	126-131
22246470-6	2012	Furthermore, cordycepin             inhibited the expression and activity of matrix metalloproteinase (MMP)-2 and             MMP-9, and simultaneously increased levels of tissue inhibitor of metalloproteinase             (TIMP)-1 and TIMP-2.	cordycepin	13-23	TIMP metallopeptidase inhibitor 1	Homo sapiens	172-230
22246470-6	2012	Furthermore, cordycepin             inhibited the expression and activity of matrix metalloproteinase (MMP)-2 and             MMP-9, and simultaneously increased levels of tissue inhibitor of metalloproteinase             (TIMP)-1 and TIMP-2.	cordycepin	13-23	TIMP metallopeptidase inhibitor 2	Homo sapiens	235-241
22650004-3	2012	Cordycepin treatment at 120 microM and 80 microM, respectively, induced apoptosis in both cells and caused the increase of cell accumulation in a time-dependent manner at the apoptotic sub-G1 phase, as evidenced by the flow cytometry (FCM) and annexin V-fluorescein isothiocyanate (FITC) analyses.	cordycepin	0-10	annexin A5	Homo sapiens	244-253
21972008-3	2012	Cordycepin inhibited melanin synthesis-related             enzymes, such as tyrosinase, tyrosinase-related protein-1 (TRP1) and tyrosinase-related             protein-2 (TRP2).	cordycepin	0-10	tyrosinase-related protein 1	Mus musculus	118-122
22149621-7	2012	In conclusion, cordycepin could ameliorate albumin-induced EMT of HK2 cells by decreasing NADPH oxidase activity and inhibiting ROS production.	cordycepin	15-25	hexokinase 2	Homo sapiens	66-69
22740928-0	2012	MLH1-deficient HCT116 colon tumor cells exhibit resistance to the cytostatic and cytotoxic effect of the poly(A) polymerase inhibitor cordycepin (3"-deoxyadenosine) in vitro.	cordycepin	134-144	poly(A) polymerase alpha	Homo sapiens	105-123
22740928-0	2012	MLH1-deficient HCT116 colon tumor cells exhibit resistance to the cytostatic and cytotoxic effect of the poly(A) polymerase inhibitor cordycepin (3"-deoxyadenosine) in vitro.	cordycepin	146-163	poly(A) polymerase alpha	Homo sapiens	105-123
22740928-1	2012	Cordycepin (3"-deoxyadenosine) is an inhibitor of poly(A) polymerase (PAP), an enzyme crucial to mRNA 3"-end processing, which produces the shortening of poly(A) tails, leading to the destabilization of mRNAs.	cordycepin	0-10	poly(A) polymerase alpha	Homo sapiens	50-68
22740928-1	2012	Cordycepin (3"-deoxyadenosine) is an inhibitor of poly(A) polymerase (PAP), an enzyme crucial to mRNA 3"-end processing, which produces the shortening of poly(A) tails, leading to the destabilization of mRNAs.	cordycepin	0-10	poly(A) polymerase alpha	Homo sapiens	70-73
22740928-1	2012	Cordycepin (3"-deoxyadenosine) is an inhibitor of poly(A) polymerase (PAP), an enzyme crucial to mRNA 3"-end processing, which produces the shortening of poly(A) tails, leading to the destabilization of mRNAs.	cordycepin	12-29	poly(A) polymerase alpha	Homo sapiens	50-68
22740928-1	2012	Cordycepin (3"-deoxyadenosine) is an inhibitor of poly(A) polymerase (PAP), an enzyme crucial to mRNA 3"-end processing, which produces the shortening of poly(A) tails, leading to the destabilization of mRNAs.	cordycepin	12-29	poly(A) polymerase alpha	Homo sapiens	70-73
22740928-9	2012	MLH1-deficient cells also exhibited reduced susceptibility to apoptosis upon treatment with cordycepin, as demonstrated by the reduced PARP-1 cleavage.	cordycepin	92-102	poly(ADP-ribose) polymerase 1	Homo sapiens	135-141
21972008-3	2012	Cordycepin inhibited melanin synthesis-related             enzymes, such as tyrosinase, tyrosinase-related protein-1 (TRP1) and tyrosinase-related             protein-2 (TRP2).	cordycepin	0-10	tyrosinase	Mus musculus	76-86
21972008-3	2012	Cordycepin inhibited melanin synthesis-related             enzymes, such as tyrosinase, tyrosinase-related protein-1 (TRP1) and tyrosinase-related             protein-2 (TRP2).	cordycepin	0-10	tyrosinase-related protein 1	Mus musculus	88-116
21972008-3	2012	Cordycepin inhibited melanin synthesis-related             enzymes, such as tyrosinase, tyrosinase-related protein-1 (TRP1) and tyrosinase-related             protein-2 (TRP2).	cordycepin	0-10	dopachrome tautomerase	Mus musculus	128-168
21972008-3	2012	Cordycepin inhibited melanin synthesis-related             enzymes, such as tyrosinase, tyrosinase-related protein-1 (TRP1) and tyrosinase-related             protein-2 (TRP2).	cordycepin	0-10	tRNA proline 2	Mus musculus	170-174
21972008-8	2012	Accordingly, cordycepin inhibited melanogenesis signaling pathways             by activating ERK and AKT signaling pathways to regulate the suppression of MITF             and its downstream pathways including tyrosinase, TRP1 and TRP2.	cordycepin	13-23	mitogen-activated protein kinase 1	Mus musculus	93-96
21972008-8	2012	Accordingly, cordycepin inhibited melanogenesis signaling pathways             by activating ERK and AKT signaling pathways to regulate the suppression of MITF             and its downstream pathways including tyrosinase, TRP1 and TRP2.	cordycepin	13-23	thymoma viral proto-oncogene 1	Mus musculus	101-104
21972008-8	2012	Accordingly, cordycepin inhibited melanogenesis signaling pathways             by activating ERK and AKT signaling pathways to regulate the suppression of MITF             and its downstream pathways including tyrosinase, TRP1 and TRP2.	cordycepin	13-23	melanogenesis associated transcription factor	Mus musculus	155-159
21972008-8	2012	Accordingly, cordycepin inhibited melanogenesis signaling pathways             by activating ERK and AKT signaling pathways to regulate the suppression of MITF             and its downstream pathways including tyrosinase, TRP1 and TRP2.	cordycepin	13-23	tyrosinase	Mus musculus	210-220
21972008-8	2012	Accordingly, cordycepin inhibited melanogenesis signaling pathways             by activating ERK and AKT signaling pathways to regulate the suppression of MITF             and its downstream pathways including tyrosinase, TRP1 and TRP2.	cordycepin	13-23	tyrosinase-related protein 1	Mus musculus	222-226
21972008-8	2012	Accordingly, cordycepin inhibited melanogenesis signaling pathways             by activating ERK and AKT signaling pathways to regulate the suppression of MITF             and its downstream pathways including tyrosinase, TRP1 and TRP2.	cordycepin	13-23	tRNA proline 2	Mus musculus	231-235
21597460-7	2011	Unexpectedly, although 3"-deoxyadenosine caused activation of eIF2alpha, it inhibited downstream pro-apoptotic events including induction of ATF4 and expression of CHOP.	cordycepin	23-40	activating transcription factor 4	Mus musculus	141-145
21597460-7	2011	Unexpectedly, although 3"-deoxyadenosine caused activation of eIF2alpha, it inhibited downstream pro-apoptotic events including induction of ATF4 and expression of CHOP.	cordycepin	23-40	DNA-damage inducible transcript 3	Mus musculus	164-168
21597460-4	2011	3"-Deoxyadenosine blocked ER stress-induced apoptosis via inhibiting the IRE1-JNK pro-apoptotic pathway.	cordycepin	0-17	endoplasmic reticulum (ER) to nucleus signalling 2	Mus musculus	73-77
21597460-10	2011	The apoptosis was significantly attenuated by administration with 3"-deoxyadenosine, and it was correlated with blunted induction of JNK and CHOP in the kidney.	cordycepin	66-83	mitogen-activated protein kinase 8	Mus musculus	133-136
21597460-4	2011	3"-Deoxyadenosine blocked ER stress-induced apoptosis via inhibiting the IRE1-JNK pro-apoptotic pathway.	cordycepin	0-17	mitogen-activated protein kinase 8	Mus musculus	78-81
21597460-10	2011	The apoptosis was significantly attenuated by administration with 3"-deoxyadenosine, and it was correlated with blunted induction of JNK and CHOP in the kidney.	cordycepin	66-83	DNA-damage inducible transcript 3	Mus musculus	141-145
21597460-5	2011	3"-Deoxyadenosine also inhibited apoptosis through reinforcement of the pro-survival eIF2alpha signaling without affecting PERK activity.	cordycepin	0-17	eukaryotic translation initiation factor 2A	Mus musculus	85-94
20803769-0	2010	Cordycepin induces apoptosis by enhancing JNK and p38 kinase activity and increasing the protein expression of Bcl-2 pro-apoptotic molecules.	cordycepin	0-10	mitogen-activated protein kinase 8	Homo sapiens	42-45
21597460-6	2011	It was associated with depression of GADD34 that dephosphorylates eIF2alpha, and dephosphorylation of eIF2alpha by salubrinal mimicked the anti-apoptotic effect of 3"-deoxyadenosine.	cordycepin	164-181	eukaryotic translation initiation factor 2A	Mus musculus	102-111
21597460-7	2011	Unexpectedly, although 3"-deoxyadenosine caused activation of eIF2alpha, it inhibited downstream pro-apoptotic events including induction of ATF4 and expression of CHOP.	cordycepin	23-40	eukaryotic translation initiation factor 2A	Mus musculus	62-71
21607289-6	2011	The effects of cordycepin on the expression of VCAM-1 and ICAM-1, and of NF-kappaB activation and nuclear translocation upon TNF-alpha stimulation resembled the effects achieved upon poly(ADP-ribose) polymerase (PARP) inhibition, suggesting that cordycepin may function as a PARP inhibitor.	cordycepin	15-25	vascular cell adhesion molecule 1	Homo sapiens	47-53
21607289-6	2011	The effects of cordycepin on the expression of VCAM-1 and ICAM-1, and of NF-kappaB activation and nuclear translocation upon TNF-alpha stimulation resembled the effects achieved upon poly(ADP-ribose) polymerase (PARP) inhibition, suggesting that cordycepin may function as a PARP inhibitor.	cordycepin	15-25	intercellular adhesion molecule 1	Homo sapiens	58-64
21607289-6	2011	The effects of cordycepin on the expression of VCAM-1 and ICAM-1, and of NF-kappaB activation and nuclear translocation upon TNF-alpha stimulation resembled the effects achieved upon poly(ADP-ribose) polymerase (PARP) inhibition, suggesting that cordycepin may function as a PARP inhibitor.	cordycepin	15-25	tumor necrosis factor	Homo sapiens	125-134
21607289-6	2011	The effects of cordycepin on the expression of VCAM-1 and ICAM-1, and of NF-kappaB activation and nuclear translocation upon TNF-alpha stimulation resembled the effects achieved upon poly(ADP-ribose) polymerase (PARP) inhibition, suggesting that cordycepin may function as a PARP inhibitor.	cordycepin	15-25	poly(ADP-ribose) polymerase 1	Homo sapiens	183-210
20961042-0	2010	Cordycepin induces apoptosis of CGTH W-2 thyroid carcinoma cells through the calcium-calpain-caspase 7-PARP pathway.	cordycepin	0-10	caspase 7	Homo sapiens	93-102
21933677-6	2011	Cordycepin also caused a dose-dependent increase in mitochondrial translocation of Bax, triggering cytosolic release of cytochrome c and activation of caspases-9 and -3.	cordycepin	0-10	BCL2 associated X, apoptosis regulator	Homo sapiens	83-86
21933677-6	2011	Cordycepin also caused a dose-dependent increase in mitochondrial translocation of Bax, triggering cytosolic release of cytochrome c and activation of caspases-9 and -3.	cordycepin	0-10	cytochrome c, somatic	Homo sapiens	120-132
21933677-6	2011	Cordycepin also caused a dose-dependent increase in mitochondrial translocation of Bax, triggering cytosolic release of cytochrome c and activation of caspases-9 and -3.	cordycepin	0-10	caspase 9	Homo sapiens	151-168
21896311-0	2011	Cordycepin decreases activity of hippocampal CA1 pyramidal neuron through membrane hyperpolarization.	cordycepin	0-10	carbonic anhydrase 1	Rattus norvegicus	45-48
21607289-6	2011	The effects of cordycepin on the expression of VCAM-1 and ICAM-1, and of NF-kappaB activation and nuclear translocation upon TNF-alpha stimulation resembled the effects achieved upon poly(ADP-ribose) polymerase (PARP) inhibition, suggesting that cordycepin may function as a PARP inhibitor.	cordycepin	15-25	poly(ADP-ribose) polymerase 1	Homo sapiens	212-216
21607289-6	2011	The effects of cordycepin on the expression of VCAM-1 and ICAM-1, and of NF-kappaB activation and nuclear translocation upon TNF-alpha stimulation resembled the effects achieved upon poly(ADP-ribose) polymerase (PARP) inhibition, suggesting that cordycepin may function as a PARP inhibitor.	cordycepin	15-25	poly(ADP-ribose) polymerase 1	Homo sapiens	275-279
21607289-6	2011	The effects of cordycepin on the expression of VCAM-1 and ICAM-1, and of NF-kappaB activation and nuclear translocation upon TNF-alpha stimulation resembled the effects achieved upon poly(ADP-ribose) polymerase (PARP) inhibition, suggesting that cordycepin may function as a PARP inhibitor.	cordycepin	246-256	tumor necrosis factor	Homo sapiens	125-134
21607289-8	2011	In a cell-free system, cordycepin inhibited PARP-1 activity at nanomolar concentrations.	cordycepin	23-33	poly(ADP-ribose) polymerase 1	Homo sapiens	44-50
21607289-9	2011	Similar to PARP inhibitors, cordycepin significantly induced killing of breast cancer susceptibility gene (BRCA1)-deficient MCF-7 cells, supporting its therapeutic use for the treatment of BRCA-deficient breast cancers.	cordycepin	28-38	poly(ADP-ribose) polymerase 1	Homo sapiens	11-15
21607289-9	2011	Similar to PARP inhibitors, cordycepin significantly induced killing of breast cancer susceptibility gene (BRCA1)-deficient MCF-7 cells, supporting its therapeutic use for the treatment of BRCA-deficient breast cancers.	cordycepin	28-38	BRCA1 DNA repair associated	Homo sapiens	107-112
21607289-11	2011	Cordycepin, to the best of our knowledge, represents the first natural product possessing PARP inhibitory traits.	cordycepin	0-10	poly(ADP-ribose) polymerase 1	Homo sapiens	90-94
19131393-0	2011	Cordycepin Induced MA-10 Mouse Leydig Tumor Cell Apoptosis through Caspase-9 Pathway.	cordycepin	0-10	caspase 9	Mus musculus	67-76
19131393-5	2011	In addition, the percentage of G1 and G2/M phase cell significantly declined by cordycepin (100 muM and 1 mM) for 24 h treatment, while the percentages of subG1 phase cell increased by 100 muM and/or 1 mM cordycepin in 6, 12 and 24 h treatments (P < 0.05), respectively, which highly suggested that cordycepin induced MA-10 cell apoptosis.	cordycepin	80-90	allograft inflammatory factor 1	Mus musculus	31-40
19131393-8	2011	In conclusion, cordycepin induced apoptosis in MA-10 mouse Leydig tumor cells through a caspase-9 and -3 and -7 dependent pathway.	cordycepin	15-25	caspase 9	Mus musculus	88-104
20937401-7	2010	In addition, cordycepin suppressed NF-kappaB translocation by blocking IkappaB-alpha (IkappaB-alpha) degradation and inhibited the phosphorylation of Akt, ERK-1/2, JNK, and p38 kinase.	cordycepin	13-23	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	71-84
20937401-7	2010	In addition, cordycepin suppressed NF-kappaB translocation by blocking IkappaB-alpha (IkappaB-alpha) degradation and inhibited the phosphorylation of Akt, ERK-1/2, JNK, and p38 kinase.	cordycepin	13-23	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	86-99
20937401-7	2010	In addition, cordycepin suppressed NF-kappaB translocation by blocking IkappaB-alpha (IkappaB-alpha) degradation and inhibited the phosphorylation of Akt, ERK-1/2, JNK, and p38 kinase.	cordycepin	13-23	thymoma viral proto-oncogene 1	Mus musculus	150-153
20937401-7	2010	In addition, cordycepin suppressed NF-kappaB translocation by blocking IkappaB-alpha (IkappaB-alpha) degradation and inhibited the phosphorylation of Akt, ERK-1/2, JNK, and p38 kinase.	cordycepin	13-23	mitogen-activated protein kinase 3	Mus musculus	155-162
20937401-7	2010	In addition, cordycepin suppressed NF-kappaB translocation by blocking IkappaB-alpha (IkappaB-alpha) degradation and inhibited the phosphorylation of Akt, ERK-1/2, JNK, and p38 kinase.	cordycepin	13-23	mitogen-activated protein kinase 8	Mus musculus	164-167
20564512-0	2010	Cordycepin suppresses TNF-alpha-induced invasion, migration and matrix metalloproteinase-9 expression in human bladder cancer cells.	cordycepin	0-10	tumor necrosis factor	Homo sapiens	22-31
20564512-0	2010	Cordycepin suppresses TNF-alpha-induced invasion, migration and matrix metalloproteinase-9 expression in human bladder cancer cells.	cordycepin	0-10	matrix metallopeptidase 9	Homo sapiens	64-90
20564512-1	2010	Cordycepin (3"-deoxyadenosine), a nucleoside derivative isolated from Cordyceps militaris, reportedly has antitumor effects, but its effect on the regulation of matrix metalloproteinases-9 (MMP-9), which regulates invasion and migration by cancer cells, has not been clearly elucidated.	cordycepin	0-10	matrix metallopeptidase 9	Homo sapiens	190-195
20564512-1	2010	Cordycepin (3"-deoxyadenosine), a nucleoside derivative isolated from Cordyceps militaris, reportedly has antitumor effects, but its effect on the regulation of matrix metalloproteinases-9 (MMP-9), which regulates invasion and migration by cancer cells, has not been clearly elucidated.	cordycepin	12-29	matrix metallopeptidase 9	Homo sapiens	190-195
20564512-4	2010	In addition, cordycepin inhibited TNF-alpha-induced proliferation in cancer cells, independent of the apoptosis pathway.	cordycepin	13-23	tumor necrosis factor	Homo sapiens	34-43
20961042-0	2010	Cordycepin induces apoptosis of CGTH W-2 thyroid carcinoma cells through the calcium-calpain-caspase 7-PARP pathway.	cordycepin	0-10	poly(ADP-ribose) polymerase 1	Homo sapiens	103-107
20803769-0	2010	Cordycepin induces apoptosis by enhancing JNK and p38 kinase activity and increasing the protein expression of Bcl-2 pro-apoptotic molecules.	cordycepin	0-10	mitogen-activated protein kinase 14	Homo sapiens	50-53
20803769-0	2010	Cordycepin induces apoptosis by enhancing JNK and p38 kinase activity and increasing the protein expression of Bcl-2 pro-apoptotic molecules.	cordycepin	0-10	BCL2 apoptosis regulator	Homo sapiens	111-116
20107539-7	2009	RESULTS: Cordycepin inhibited the production of NO and pro-inflammatory cytokines such as IL-1beta, IL-6, and TNF-alpha in LPS-activated macrophages via suppressing protein expression of pro-inflammatory mediators.	cordycepin	9-19	interleukin 1 beta	Mus musculus	90-98
20043135-0	2010	Cordycepin inhibits TPA-induced matrix metalloproteinase-9 expression by suppressing the MAPK/AP-1 pathway in MCF-7 human breast cancer cells.	cordycepin	0-10	matrix metallopeptidase 9	Homo sapiens	32-58
20043135-0	2010	Cordycepin inhibits TPA-induced matrix metalloproteinase-9 expression by suppressing the MAPK/AP-1 pathway in MCF-7 human breast cancer cells.	cordycepin	0-10	mitogen-activated protein kinase 1	Homo sapiens	89-93
20043135-3	2010	We investigated whether cordycepin, an NF-kappaB or AP-1 inhibitor, can modulate MMP-9 expression and cell invasion in MCF-7 cells.	cordycepin	24-34	matrix metallopeptidase 9	Homo sapiens	81-86
20043135-9	2010	Cordycepin inhibits TPA-induced MMP-9 expression and cell invasion by suppressing AP-1 activation.	cordycepin	0-10	matrix metallopeptidase 9	Homo sapiens	32-37
20043135-10	2010	Also, cordycepin suppressed the MAPK signaling pathway.	cordycepin	6-16	mitogen-activated protein kinase 1	Homo sapiens	32-36
20043135-11	2010	Cordycepin is a potent inhibitor of TPA-induced MMP-9 expression and blocks strongly the ability of AP-1 activation via MAPK signaling pathway in MCF-7 cells.	cordycepin	0-10	matrix metallopeptidase 9	Homo sapiens	48-53
20043135-11	2010	Cordycepin is a potent inhibitor of TPA-induced MMP-9 expression and blocks strongly the ability of AP-1 activation via MAPK signaling pathway in MCF-7 cells.	cordycepin	0-10	mitogen-activated protein kinase 1	Homo sapiens	120-124
19940154-9	2010	We conclude that many of the reported biological effects of cordycepin are likely to be due to its effects on mTOR and AMPK signaling.	cordycepin	60-70	mechanistic target of rapamycin kinase	Homo sapiens	110-114
19940154-9	2010	We conclude that many of the reported biological effects of cordycepin are likely to be due to its effects on mTOR and AMPK signaling.	cordycepin	60-70	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	119-123
20724804-5	2010	In HepG2 cells, cordycepin stimulated robust concentration- and time-dependent AMPK activation that correlated with the activation of ACC and the suppression of lipid biosynthesis.	cordycepin	16-26	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	79-83
20724804-6	2010	However, pretreatment with compound C, a specific inhibitor of AMPK, substantially abolished the effects of cordycepin on AMPK activation and lipid biosynthesis inhibition.	cordycepin	108-118	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	63-67
20724804-6	2010	However, pretreatment with compound C, a specific inhibitor of AMPK, substantially abolished the effects of cordycepin on AMPK activation and lipid biosynthesis inhibition.	cordycepin	108-118	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	122-126
20724804-7	2010	These results indicate that cordycepin prevents hyperlipidemia via activation of AMPK.	cordycepin	28-38	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	81-85
19833164-0	2010	c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells.	cordycepin	42-52	mitogen-activated protein kinase 8	Homo sapiens	0-25
19833164-6	2010	Moreover, cordycepin treatment induced activation of JNK (c-Jun N-terminal kinases).	cordycepin	10-20	mitogen-activated protein kinase 8	Homo sapiens	53-56
19833164-6	2010	Moreover, cordycepin treatment induced activation of JNK (c-Jun N-terminal kinases).	cordycepin	10-20	mitogen-activated protein kinase 8	Homo sapiens	58-82
19733546-3	2009	Cordycepin treatment, at a dose of 200 microM (IC(50)) during cell-cycle progression resulted in significant and dose-dependent growth inhibition, which was largely due to G2/M-phase arrest, and resulted in an up-regulation of p21WAF1 expression, independent of the p53 pathway.	cordycepin	0-10	tumor protein p53	Homo sapiens	266-269
19733546-4	2009	Moreover, treatment with cordycepin-induced phosphorylation of JNK (c-Jun N-terminal kinases).	cordycepin	25-35	mitogen-activated protein kinase 8	Homo sapiens	63-66
19733546-4	2009	Moreover, treatment with cordycepin-induced phosphorylation of JNK (c-Jun N-terminal kinases).	cordycepin	25-35	mitogen-activated protein kinase 8	Homo sapiens	68-92
20107539-7	2009	RESULTS: Cordycepin inhibited the production of NO and pro-inflammatory cytokines such as IL-1beta, IL-6, and TNF-alpha in LPS-activated macrophages via suppressing protein expression of pro-inflammatory mediators.	cordycepin	9-19	interleukin 6	Mus musculus	100-104
20107539-7	2009	RESULTS: Cordycepin inhibited the production of NO and pro-inflammatory cytokines such as IL-1beta, IL-6, and TNF-alpha in LPS-activated macrophages via suppressing protein expression of pro-inflammatory mediators.	cordycepin	9-19	tumor necrosis factor	Mus musculus	110-119
19056796-12	2009	CONCLUSIONS: Cordycepin is a potent inhibitor of IL-1beta-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs.	cordycepin	13-23	mitogen-activated protein kinase 8	Homo sapiens	134-137
19324962-4	2009	Unexpectedly, cordycepin treatment modulated 3" end heterogeneity of ACT1 and ASC1 mRNAs and rapidly induced extended transcripts derived from CYH2 and NEL025c loci.	cordycepin	14-24	actin	Saccharomyces cerevisiae S288C	69-73
19324962-4	2009	Unexpectedly, cordycepin treatment modulated 3" end heterogeneity of ACT1 and ASC1 mRNAs and rapidly induced extended transcripts derived from CYH2 and NEL025c loci.	cordycepin	14-24	ribosomal 60S subunit protein L28	Saccharomyces cerevisiae S288C	143-147
19056796-0	2009	Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts.	cordycepin	0-10	interleukin 1 beta	Homo sapiens	20-28
19324962-4	2009	Unexpectedly, cordycepin treatment modulated 3" end heterogeneity of ACT1 and ASC1 mRNAs and rapidly induced extended transcripts derived from CYH2 and NEL025c loci.	cordycepin	14-24	guanine nucleotide-binding protein subunit beta	Saccharomyces cerevisiae S288C	78-82
19305122-4	2009	Cordycepin suppressed the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and heat shock protein 27 (Hsp27), but not that of extracellular signal-regulated kinase (ERK) 1/2 in RASMCs stimulated by PDGF-BB.	cordycepin	0-10	mitogen activated protein kinase 14	Rattus norvegicus	45-81
19305122-4	2009	Cordycepin suppressed the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and heat shock protein 27 (Hsp27), but not that of extracellular signal-regulated kinase (ERK) 1/2 in RASMCs stimulated by PDGF-BB.	cordycepin	0-10	mitogen activated protein kinase 14	Rattus norvegicus	83-91
19305122-4	2009	Cordycepin suppressed the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and heat shock protein 27 (Hsp27), but not that of extracellular signal-regulated kinase (ERK) 1/2 in RASMCs stimulated by PDGF-BB.	cordycepin	0-10	heat shock protein family B (small) member 1	Rattus norvegicus	97-118
19305122-4	2009	Cordycepin suppressed the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and heat shock protein 27 (Hsp27), but not that of extracellular signal-regulated kinase (ERK) 1/2 in RASMCs stimulated by PDGF-BB.	cordycepin	0-10	heat shock protein family B (small) member 1	Rattus norvegicus	120-125
19056796-12	2009	CONCLUSIONS: Cordycepin is a potent inhibitor of IL-1beta-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs.	cordycepin	13-23	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-142
19056796-0	2009	Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts.	cordycepin	0-10	matrix metallopeptidase 1	Homo sapiens	37-42
16899239-0	2006	Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells.	cordycepin	0-10	thymoma viral proto-oncogene 1	Mus musculus	100-103
19056796-0	2009	Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts.	cordycepin	0-10	matrix metallopeptidase 3	Homo sapiens	47-52
19056796-3	2009	In this study, we aimed at the inhibitory effect of cordycepin on IL-1beta-induced MMP-1 and MMP-3 expression as well as the molecular basis using RA synovial fibroblasts (RASFs).	cordycepin	52-62	interleukin 1 beta	Homo sapiens	66-74
19056796-3	2009	In this study, we aimed at the inhibitory effect of cordycepin on IL-1beta-induced MMP-1 and MMP-3 expression as well as the molecular basis using RA synovial fibroblasts (RASFs).	cordycepin	52-62	matrix metallopeptidase 1	Homo sapiens	83-88
19056796-3	2009	In this study, we aimed at the inhibitory effect of cordycepin on IL-1beta-induced MMP-1 and MMP-3 expression as well as the molecular basis using RA synovial fibroblasts (RASFs).	cordycepin	52-62	matrix metallopeptidase 3	Homo sapiens	93-98
19056796-9	2009	RESULTS: Cordycepin inhibited IL-1beta-induced MMP-1 and MMP-3 expressions in RASFs in a dose-dependent manner.	cordycepin	9-19	interleukin 1 beta	Homo sapiens	30-38
19056796-9	2009	RESULTS: Cordycepin inhibited IL-1beta-induced MMP-1 and MMP-3 expressions in RASFs in a dose-dependent manner.	cordycepin	9-19	matrix metallopeptidase 1	Homo sapiens	47-52
19056796-9	2009	RESULTS: Cordycepin inhibited IL-1beta-induced MMP-1 and MMP-3 expressions in RASFs in a dose-dependent manner.	cordycepin	9-19	matrix metallopeptidase 3	Homo sapiens	57-62
19056796-11	2009	Moreover, cordycepin significantly inhibited IL-1beta-induced p38/JNK and AP-1 activation, but not extracellular signal-regulated kinase (ERK) and NF-kappaB activation.	cordycepin	10-20	interleukin 1 beta	Homo sapiens	45-53
19056796-11	2009	Moreover, cordycepin significantly inhibited IL-1beta-induced p38/JNK and AP-1 activation, but not extracellular signal-regulated kinase (ERK) and NF-kappaB activation.	cordycepin	10-20	mitogen-activated protein kinase 14	Homo sapiens	62-65
19056796-11	2009	Moreover, cordycepin significantly inhibited IL-1beta-induced p38/JNK and AP-1 activation, but not extracellular signal-regulated kinase (ERK) and NF-kappaB activation.	cordycepin	10-20	mitogen-activated protein kinase 8	Homo sapiens	66-69
19056796-11	2009	Moreover, cordycepin significantly inhibited IL-1beta-induced p38/JNK and AP-1 activation, but not extracellular signal-regulated kinase (ERK) and NF-kappaB activation.	cordycepin	10-20	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-78
19056796-12	2009	CONCLUSIONS: Cordycepin is a potent inhibitor of IL-1beta-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs.	cordycepin	13-23	interleukin 1 beta	Homo sapiens	49-57
19056796-12	2009	CONCLUSIONS: Cordycepin is a potent inhibitor of IL-1beta-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs.	cordycepin	13-23	mitogen-activated protein kinase 14	Homo sapiens	130-133
18782572-8	2008	To investigate the mechanism by which cordycepin inhibits the remodeling of the vessel wall and/or the accumulation of cells and ECM, we examined the activation of MMP systems in collagen type I-activated RaoSMCs.	cordycepin	38-48	matrix metallopeptidase 2	Rattus norvegicus	164-167
18782572-9	2008	Cordycepin markedly inhibited the activation of MMP-2 and -9 as well as the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in a dose-dependent manner in collagen type I-activated RaoSMCs.	cordycepin	0-10	matrix metallopeptidase 2	Rattus norvegicus	48-60
18782572-9	2008	Cordycepin markedly inhibited the activation of MMP-2 and -9 as well as the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in a dose-dependent manner in collagen type I-activated RaoSMCs.	cordycepin	0-10	basigin (Ok blood group)	Rattus norvegicus	90-136
18782572-9	2008	Cordycepin markedly inhibited the activation of MMP-2 and -9 as well as the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in a dose-dependent manner in collagen type I-activated RaoSMCs.	cordycepin	0-10	basigin (Ok blood group)	Rattus norvegicus	138-145
18716208-10	2008	Cordycepin, an inhibitor of polyadenylation, disrupted LTP induced by either GH application or TBS.	cordycepin	0-10	growth hormone	Mus musculus	77-79
18084742-0	2008	Cordycepin (3"-deoxyadenosine) inhibits the growth of B16-BL6 mouse melanoma cells through the stimulation of adenosine A3 receptor followed by glycogen synthase kinase-3beta activation and cyclin D1 suppression.	cordycepin	0-10	glycogen synthase kinase 3 beta	Mus musculus	144-174
18084742-0	2008	Cordycepin (3"-deoxyadenosine) inhibits the growth of B16-BL6 mouse melanoma cells through the stimulation of adenosine A3 receptor followed by glycogen synthase kinase-3beta activation and cyclin D1 suppression.	cordycepin	0-10	cyclin D1	Mus musculus	190-199
18084742-0	2008	Cordycepin (3"-deoxyadenosine) inhibits the growth of B16-BL6 mouse melanoma cells through the stimulation of adenosine A3 receptor followed by glycogen synthase kinase-3beta activation and cyclin D1 suppression.	cordycepin	12-29	glycogen synthase kinase 3 beta	Mus musculus	144-174
18084742-0	2008	Cordycepin (3"-deoxyadenosine) inhibits the growth of B16-BL6 mouse melanoma cells through the stimulation of adenosine A3 receptor followed by glycogen synthase kinase-3beta activation and cyclin D1 suppression.	cordycepin	12-29	cyclin D1	Mus musculus	190-199
17229422-0	2007	Cordycepin (3"-deoxyadenosine) inhibits human platelet aggregation in a cyclic AMP- and cyclic GMP-dependent manner.	cordycepin	0-10	5'-nucleotidase, cytosolic II	Homo sapiens	95-98
17229422-0	2007	Cordycepin (3"-deoxyadenosine) inhibits human platelet aggregation in a cyclic AMP- and cyclic GMP-dependent manner.	cordycepin	12-29	5'-nucleotidase, cytosolic II	Homo sapiens	95-98
16899239-0	2006	Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells.	cordycepin	0-10	mitogen-activated protein kinase 14	Mus musculus	108-111
16899239-6	2006	To investigate the mechanism by which cordycepin inhibits NO production and inducible nitric oxide synthase (iNOS) expression, we examined the activation of Akt and MAP kinases in LPS-activated macrophage.	cordycepin	38-48	nitric oxide synthase 2, inducible	Mus musculus	76-107
16899239-6	2006	To investigate the mechanism by which cordycepin inhibits NO production and inducible nitric oxide synthase (iNOS) expression, we examined the activation of Akt and MAP kinases in LPS-activated macrophage.	cordycepin	38-48	thymoma viral proto-oncogene 1	Mus musculus	157-160
16899239-7	2006	Cordycepin markedly inhibited the phosphorylation of Akt and p38 in dose-dependent manners in LPS-activated macrophage.	cordycepin	0-10	thymoma viral proto-oncogene 1	Mus musculus	53-56
16899239-7	2006	Cordycepin markedly inhibited the phosphorylation of Akt and p38 in dose-dependent manners in LPS-activated macrophage.	cordycepin	0-10	mitogen-activated protein kinase 14	Mus musculus	61-64
12398919-0	2002	Effect of cordycepin on interleukin-10 production of human peripheral blood mononuclear cells.	cordycepin	10-20	interleukin 10	Homo sapiens	24-38
16137671-5	2005	This cyclin A2 may be generated from maternally recruited cyclin A2 mRNA because its accumulation was inhibited by 3"-deoxyadenosine, which inhibits mRNA polyadenylation.	cordycepin	115-132	cyclin A2	Mus musculus	5-14
16137671-5	2005	This cyclin A2 may be generated from maternally recruited cyclin A2 mRNA because its accumulation was inhibited by 3"-deoxyadenosine, which inhibits mRNA polyadenylation.	cordycepin	115-132	cyclin A2	Mus musculus	58-67
15736128-6	2005	Polyadenylation of cyclin B1 was also completely prevented when 3"-dA was added at 0 hr, and greatly reduced when added at 6 hr.	cordycepin	64-69	cyclin B1	Bos taurus	19-28
14559831-6	2003	The inhibitory effects on cell growth and to some extent on ERalpha were mimicked by 2-chloro-adenosine >3"-deoxyadenosine> adenosine but not by a variety of other ligands.	cordycepin	108-125	estrogen receptor 1	Homo sapiens	60-67
12398919-8	2002	At the same time, cordycepin inhibited phytohaemagglutinin-induced interleukin-2 production and proliferation of peripheral blood mononuclear cells.	cordycepin	18-28	interleukin 2	Homo sapiens	67-80
11181506-5	2001	Moreover, CYP3A1 mRNA levels decreased more rapidly than those of CYP3A2 as determined following inhibition of transcription with actinomycin D or cordycepin.	cordycepin	147-157	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	10-16
11566717-9	2001	This increase, as well as the increase in the amount of cyclin A2 protein, is prevented by 3"-deoxyadenosine (3"-dA), an inhibitor of polyadenylation.	cordycepin	91-108	cyclin A2	Mus musculus	56-65
11566717-9	2001	This increase, as well as the increase in the amount of cyclin A2 protein, is prevented by 3"-deoxyadenosine (3"-dA), an inhibitor of polyadenylation.	cordycepin	110-115	cyclin A2	Mus musculus	56-65
10609556-1	2000	The nucleoside analogue cordycepin (3"-deoxyadenosine, 3"-dA) is substantially more cytotoxic to terminal deoxynucleotidyl transferase positive (TdT+) leukemic cells than to TdT leukemic cells in vitro in the presence of an adenosine deaminase inhibitor, deoxycoformycin (dCF), and has been considered as a therapeutic agent for TdT+ leukemia.	cordycepin	24-34	DNA nucleotidylexotransferase	Homo sapiens	145-148
10609556-1	2000	The nucleoside analogue cordycepin (3"-deoxyadenosine, 3"-dA) is substantially more cytotoxic to terminal deoxynucleotidyl transferase positive (TdT+) leukemic cells than to TdT leukemic cells in vitro in the presence of an adenosine deaminase inhibitor, deoxycoformycin (dCF), and has been considered as a therapeutic agent for TdT+ leukemia.	cordycepin	24-34	DNA nucleotidylexotransferase	Homo sapiens	174-177
10609556-1	2000	The nucleoside analogue cordycepin (3"-deoxyadenosine, 3"-dA) is substantially more cytotoxic to terminal deoxynucleotidyl transferase positive (TdT+) leukemic cells than to TdT leukemic cells in vitro in the presence of an adenosine deaminase inhibitor, deoxycoformycin (dCF), and has been considered as a therapeutic agent for TdT+ leukemia.	cordycepin	36-53	DNA nucleotidylexotransferase	Homo sapiens	145-148
10718633-11	2000	Relative ADA activity towards 3"-deoxyadenosine and 6-chloropurine riboside was lower by 30% and 40%, respectively.	cordycepin	30-47	adenosine deaminase	Mus musculus	9-12
8667637-2	1996	Cordycepin-treated, ADA-inhibited, TdT-positive cells undergo the classic changes associated with drug-induced apoptosis: reduction in cell volume, chromatin clumping, membrane blebbing, and 180-bp multimer DNA laddering on agarose gels.	cordycepin	0-10	DNA nucleotidylexotransferase	Homo sapiens	35-38
10563371-0	1999	Exploration of the effect of sterically demanding 3"-amido substitution of 3"-deoxyadenosines towards inhibition of cyclin-dependent kinase 1.	cordycepin	75-93	cyclin dependent kinase 1	Homo sapiens	116-141
8667637-8	1996	A role for TdT as an apoptotic endonuclease in TdT-positive leukemia cells following cordycepin exposure is now the subject of on-going work.	cordycepin	85-95	DNA nucleotidylexotransferase	Homo sapiens	11-14
8667637-8	1996	A role for TdT as an apoptotic endonuclease in TdT-positive leukemia cells following cordycepin exposure is now the subject of on-going work.	cordycepin	85-95	DNA nucleotidylexotransferase	Homo sapiens	47-50
34497073-9	2021	RESULTS: We show that NUC-7738 overcomes the cancer resistance mechanisms that limit the activity of 3"-dA and that its activation is dependent on ProTide cleavage by the enzyme histidine triad nucleotide binding protein 1.	cordycepin	101-106	histidine triad nucleotide binding protein 1	Homo sapiens	178-222
1934297-5	1991	However, if cells were treated with either actinomycin D, alpha-amanitin or cordycepin, which are inhibitors of RNA synthesis, after exposure to cycloheximide, prominent induction of AHH activity was observed, the levels being almost equal to those for hepatocytes treated with benz[a]anthracene, a potent AHH inducer.	cordycepin	76-86	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	183-186
1934297-5	1991	However, if cells were treated with either actinomycin D, alpha-amanitin or cordycepin, which are inhibitors of RNA synthesis, after exposure to cycloheximide, prominent induction of AHH activity was observed, the levels being almost equal to those for hepatocytes treated with benz[a]anthracene, a potent AHH inducer.	cordycepin	76-86	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	306-309
1701014-6	1990	Second, c-myc messengers which carry a short poly(A) tail, as a result of prolonged actinomycin D or 3"-deoxyadenosine treatment, were not stabilized by the inhibition of translation.	cordycepin	101-118	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	8-13
7845029-13	1995	Cordycepin in the co-presence of an ADA inhibitor may be effective in the treatment of TdT-positive hematological malignancies.	cordycepin	0-10	adenosine deaminase	Homo sapiens	36-39
7894891-5	1994	The stimulated increase in TAT activity elicited by the hormone or cyclic nucleotide was prevented by injection of cycloheximide or cordycepin.	cordycepin	132-142	tyrosine aminotransferase	Gallus gallus	27-30
34953496-14	2021	CONCLUSIONS: In brief, this study provides comprehensive evidence that cordycepin inhibits osteosarcoma cell growth and invasion and induces osteosarcoma cell apoptosis by activating AMPK and inhibiting the AKT/mTOR signaling pathway and enhances the sensitivity of osteosarcoma cells to cisplatin, suggesting that cordycepin is a promising treatment for osteosarcoma.	cordycepin	71-81	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	183-187
34953496-14	2021	CONCLUSIONS: In brief, this study provides comprehensive evidence that cordycepin inhibits osteosarcoma cell growth and invasion and induces osteosarcoma cell apoptosis by activating AMPK and inhibiting the AKT/mTOR signaling pathway and enhances the sensitivity of osteosarcoma cells to cisplatin, suggesting that cordycepin is a promising treatment for osteosarcoma.	cordycepin	71-81	AKT serine/threonine kinase 1	Homo sapiens	207-210
34953496-14	2021	CONCLUSIONS: In brief, this study provides comprehensive evidence that cordycepin inhibits osteosarcoma cell growth and invasion and induces osteosarcoma cell apoptosis by activating AMPK and inhibiting the AKT/mTOR signaling pathway and enhances the sensitivity of osteosarcoma cells to cisplatin, suggesting that cordycepin is a promising treatment for osteosarcoma.	cordycepin	71-81	mechanistic target of rapamycin kinase	Homo sapiens	211-215
34744731-6	2021	Our in vitro results showed that cordycepin enhanced Mfn2-medicated mitochondrial fusion, improved mitochondrial function, and reduced cardiomyocyte apoptosis in high-glucose/high-fat cultured simulated ischemia/reperfusion cardiomyocytes.	cordycepin	33-43	mitofusin 2	Mus musculus	53-57
34157317-3	2021	In the model of LPS-induced inflammation, cordycepin was found to significantly inhibited the expression of pro-inflammatory cytokines such as tnf-alpha, il-1beta, il-6, and il-8.	cordycepin	42-52	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	143-152
34157317-3	2021	In the model of LPS-induced inflammation, cordycepin was found to significantly inhibited the expression of pro-inflammatory cytokines such as tnf-alpha, il-1beta, il-6, and il-8.	cordycepin	42-52	interleukin 6 (interferon, beta 2)	Danio rerio	164-168
34157317-3	2021	In the model of LPS-induced inflammation, cordycepin was found to significantly inhibited the expression of pro-inflammatory cytokines such as tnf-alpha, il-1beta, il-6, and il-8.	cordycepin	42-52	chemokine (C-X-C motif) ligand 8a	Danio rerio	174-178
34744731-7	2021	Furthermore, we found that knockout of Mfn2 significantly blocked the cardioprotective effects of cordycepin in diabetic mice.	cordycepin	98-108	mitofusin 2	Mus musculus	39-43
35414771-4	2022	We also performed immunohistochemistry (IHC) to test CTSL expression and western blot to monitor its regulation by cordycepin (CD), and N6, N6-dimethyladenosine (m6 2A), respectively.	cordycepin	115-125	cathepsin L	Homo sapiens	53-57
34641429-8	2021	In contrast, the effects of cordycepin on the p38 and Jun kinases were variable, as were the effects on cell cycle arrest (53 papers), suggesting these are cell-specific responses.	cordycepin	28-38	mitogen-activated protein kinase 14	Homo sapiens	46-49
34671211-12	2021	Moreover, Cordycepin (CD) inhibited furin expression in a dosage dependent manner.	cordycepin	10-20	furin, paired basic amino acid cleaving enzyme	Homo sapiens	36-41
34671211-12	2021	Moreover, Cordycepin (CD) inhibited furin expression in a dosage dependent manner.	cordycepin	22-24	furin, paired basic amino acid cleaving enzyme	Homo sapiens	36-41
34671211-14	2021	CD might have a potential to develop an anti-SARS-CoV-2 drug through inhibiting furin expression.	cordycepin	0-2	furin, paired basic amino acid cleaving enzyme	Homo sapiens	80-85
34070360-0	2021	Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/beta-Catenin Pathway Stimulation by Regulating GSK3b Activity.	cordycepin	14-24	catenin beta 1	Homo sapiens	102-114
34070360-0	2021	Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/beta-Catenin Pathway Stimulation by Regulating GSK3b Activity.	cordycepin	14-24	glycogen synthase kinase 3 beta	Homo sapiens	149-154
34070360-6	2021	The enhanced gene expression by adenosine and cordycepin was abrogated by adenosine A2A and A2B receptor inhibitors, ZM241385 and PSH603, and protein kinase A (PKA) inhibitor H89, indicating the involvement of adenosine receptor A2A, A2B and PKA.	cordycepin	46-56	adenosine A2a receptor	Homo sapiens	210-232
34070360-9	2021	In conclusion, our data strongly demonstrate that adenosine and cordycepin stimulate the Wnt/beta-catenin signaling through the activation of adenosine receptor, possibly promoting the tissue remodeling process and suggest their therapeutic potential for treating skin wounds.	cordycepin	64-74	catenin beta 1	Homo sapiens	93-105
35427564-0	2022	Cordycepin ameliorates acute hypobaric hypoxia induced blood-brain barrier disruption, and cognitive impairment partly by suppressing the TLR4/NF-kappaB/MMP-9 pathway in the adult rats.	cordycepin	0-10	toll-like receptor 4	Rattus norvegicus	138-142
35427564-0	2022	Cordycepin ameliorates acute hypobaric hypoxia induced blood-brain barrier disruption, and cognitive impairment partly by suppressing the TLR4/NF-kappaB/MMP-9 pathway in the adult rats.	cordycepin	0-10	matrix metallopeptidase 9	Rattus norvegicus	153-158
35427564-15	2022	CONCLUSIONS: Cordycepin could ameliorate HH-induced neuroinflammation, BBB disruption, and cognitive damage partly by inhibiting the TLR-4/NF-kappaB/MMP-9 pathway.	cordycepin	13-23	toll-like receptor 4	Rattus norvegicus	133-138
35427564-15	2022	CONCLUSIONS: Cordycepin could ameliorate HH-induced neuroinflammation, BBB disruption, and cognitive damage partly by inhibiting the TLR-4/NF-kappaB/MMP-9 pathway.	cordycepin	13-23	matrix metallopeptidase 9	Rattus norvegicus	149-154
35352454-14	2022	Mechanistically, reduced expression of the Klotho protein SOD1 caused by d-galactose was recovered in rats co-treated with cordycepin.	cordycepin	123-133	Klotho	Rattus norvegicus	43-49
35352454-14	2022	Mechanistically, reduced expression of the Klotho protein SOD1 caused by d-galactose was recovered in rats co-treated with cordycepin.	cordycepin	123-133	superoxide dismutase 1	Rattus norvegicus	58-62
35191475-9	2022	Cordycepin treatment resulted in around 50% inflammatory cytokine production (e.g., IL-6 and IL-1beta) and about 60% immune cell infiltration (e.g., Th17 cells) when compared to vehicle control group.	cordycepin	0-10	interleukin 6	Homo sapiens	84-88
35191475-9	2022	Cordycepin treatment resulted in around 50% inflammatory cytokine production (e.g., IL-6 and IL-1beta) and about 60% immune cell infiltration (e.g., Th17 cells) when compared to vehicle control group.	cordycepin	0-10	interleukin 1 alpha	Homo sapiens	93-101
34297967-9	2021	Cordycepin mitigates LPS-mediated toll-like receptor activation by activating adenosine receptor A1, thereby improving antioxidant enzymes (superoxide dismutase, glutathione peroxidase) levels.	cordycepin	0-10	adenosine A1 receptor	Homo sapiens	78-99
35414771-14	2022	Furthermore, CD or m6 2A inhibited CTSL expression in the cancer cell lines A549, MDA-MB-231, and/or PC3 in a dose dependent manner.	cordycepin	13-15	cathepsin L	Homo sapiens	35-39
35414771-14	2022	Furthermore, CD or m6 2A inhibited CTSL expression in the cancer cell lines A549, MDA-MB-231, and/or PC3 in a dose dependent manner.	cordycepin	13-15	proprotein convertase subtilisin/kexin type 1	Homo sapiens	101-104
35120580-10	2022	Additional miR-26a transfection in MYC over-expressing cells could reverse MYC over-expression-promoted proliferation, which could be further potentiated by cordycepin treatment.	cordycepin	157-167	microRNA 26a-1	Homo sapiens	11-18
35230668-0	2022	Cordycepin alleviates myocardial ischemia/reperfusion injury by enhancing autophagy via AMPK-mTOR pathway.	cordycepin	0-10	mechanistic target of rapamycin kinase	Mus musculus	93-97
35120580-10	2022	Additional miR-26a transfection in MYC over-expressing cells could reverse MYC over-expression-promoted proliferation, which could be further potentiated by cordycepin treatment.	cordycepin	157-167	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	35-38
35120580-10	2022	Additional miR-26a transfection in MYC over-expressing cells could reverse MYC over-expression-promoted proliferation, which could be further potentiated by cordycepin treatment.	cordycepin	157-167	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	75-78
34850068-0	2022	Cordycepin induces M1/M2 macrophage polarization to attenuate the liver and lung damage and immunodeficiency in immature mice with sepsis via NF-kappaB/p65 inhibition.	cordycepin	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-155
3257721-3	1988	In vitro studies showed that the 3"-dANO resistant Ehrlich cells initiate the metabolism of 3"-dANO by a reduction to 3"-deoxyadenosine, which is converted primarily to 3"-deoxyinosine by adenosine deaminase and, to a small extent, phosphorylated to the cell toxic agent 3"-dATP.	cordycepin	118-135	adenosine deaminase	Mus musculus	188-207
3263372-0	1988	Intracellular inhibition of chromatin binding and transformation of androgen receptor by 3"-deoxyadenosine.	cordycepin	89-106	androgen receptor	Rattus norvegicus	68-85
3263372-1	1988	Incubation of minced rat ventral prostate with 3"-deoxyadenosine (3"-dA) prior to labeling with the androgen, tritiated 7 alpha, 17 alpha-dimethyl-19-nortestosterone, reduced the level of androgen receptor bound to chromatin and increased the level of cytosolic androgen receptor and the fraction of cytosolic androgen receptor that did not bind to DNA.	cordycepin	47-64	androgen receptor	Rattus norvegicus	188-205
3263372-1	1988	Incubation of minced rat ventral prostate with 3"-deoxyadenosine (3"-dA) prior to labeling with the androgen, tritiated 7 alpha, 17 alpha-dimethyl-19-nortestosterone, reduced the level of androgen receptor bound to chromatin and increased the level of cytosolic androgen receptor and the fraction of cytosolic androgen receptor that did not bind to DNA.	cordycepin	47-64	androgen receptor	Rattus norvegicus	262-279
3263372-1	1988	Incubation of minced rat ventral prostate with 3"-deoxyadenosine (3"-dA) prior to labeling with the androgen, tritiated 7 alpha, 17 alpha-dimethyl-19-nortestosterone, reduced the level of androgen receptor bound to chromatin and increased the level of cytosolic androgen receptor and the fraction of cytosolic androgen receptor that did not bind to DNA.	cordycepin	47-64	androgen receptor	Rattus norvegicus	262-279
3263372-1	1988	Incubation of minced rat ventral prostate with 3"-deoxyadenosine (3"-dA) prior to labeling with the androgen, tritiated 7 alpha, 17 alpha-dimethyl-19-nortestosterone, reduced the level of androgen receptor bound to chromatin and increased the level of cytosolic androgen receptor and the fraction of cytosolic androgen receptor that did not bind to DNA.	cordycepin	66-71	androgen receptor	Rattus norvegicus	188-205
3263372-1	1988	Incubation of minced rat ventral prostate with 3"-deoxyadenosine (3"-dA) prior to labeling with the androgen, tritiated 7 alpha, 17 alpha-dimethyl-19-nortestosterone, reduced the level of androgen receptor bound to chromatin and increased the level of cytosolic androgen receptor and the fraction of cytosolic androgen receptor that did not bind to DNA.	cordycepin	66-71	androgen receptor	Rattus norvegicus	262-279
3263372-1	1988	Incubation of minced rat ventral prostate with 3"-deoxyadenosine (3"-dA) prior to labeling with the androgen, tritiated 7 alpha, 17 alpha-dimethyl-19-nortestosterone, reduced the level of androgen receptor bound to chromatin and increased the level of cytosolic androgen receptor and the fraction of cytosolic androgen receptor that did not bind to DNA.	cordycepin	66-71	androgen receptor	Rattus norvegicus	262-279
3263372-4	1988	Labeled cytosolic androgen receptor from 3"-dA-treated prostate had properties that were similar to those exhibited by untransformed androgen receptor from prostate cytosol prepared in the presence of Na2MoO4, an inhibitor of receptor transformation in cell-free systems.	cordycepin	41-46	androgen receptor	Rattus norvegicus	18-35
3263372-7	1988	These findings show that androgen receptor transformation does take place in intact prostate cells and suggest that 3"-dA inhibits chromatin binding of androgen receptor by interfering with androgen receptor transformation.	cordycepin	116-121	androgen receptor	Rattus norvegicus	25-42
3263372-7	1988	These findings show that androgen receptor transformation does take place in intact prostate cells and suggest that 3"-dA inhibits chromatin binding of androgen receptor by interfering with androgen receptor transformation.	cordycepin	116-121	androgen receptor	Rattus norvegicus	152-169
3263372-7	1988	These findings show that androgen receptor transformation does take place in intact prostate cells and suggest that 3"-dA inhibits chromatin binding of androgen receptor by interfering with androgen receptor transformation.	cordycepin	116-121	androgen receptor	Rattus norvegicus	152-169
3125430-3	1988	The substrate specificity of trypanosomal MeSAdo/Ado phosphorylase differed from that of a mammalian MeSAdo phosphorylase (derived from murine Sarcoma 180 cells) in that it was able to phosphorolyze 2"-deoxyadenosine, 3"-deoxyadenosine and 2",3"-dideoxyadenosine.	cordycepin	218-235	methylthioadenosine phosphorylase	Homo sapiens	101-121
6603904-8	1983	Resistance to ara-A, and cross-resistance to tubercidin, methylmercaptopurine ribonucleoside, and cordycepin is attributed to loss of adenosine kinase activity.	cordycepin	98-108	adenosine kinase	Mus musculus	134-150
3031058-2	1987	The hormone-mediated increase in tyrosinase activity is dependent upon continued transcription since the enzyme induction is suppressed by either cordycepin (1 microgram/ml) or alpha-amanitin (10 micrograms/ml).	cordycepin	146-156	tyrosinase	Mus musculus	33-43
3486942-6	1986	The Ki for adenosine inhibition of the CaM-sensitive adenylate cyclase was approximately 2.6 X 10(-4) M. 5"-Guanylylimidodiphosphate and CaM did not affect the Ki of 3"-deoxyadenosine for the enzyme, but the presence of Ca2+ in the millimolar range raised the Ki by a factor of 5.	cordycepin	166-183	calmodulin	Bos taurus	39-42
3087388-9	1986	Effects of cordycepin upon development of NAT activity were similar to those of 3-aminobenzamide but less marked.	cordycepin	11-21	arylamine N-acetyltransferase, liver isozyme	Gallus gallus	42-45
6323405-5	1984	The half-life of glucokinase mRNA, determined after the administration of cordycepin to glucose-fed animals, was approximately 40 min.	cordycepin	74-84	glucokinase	Rattus norvegicus	17-28
6410926-8	1983	Cordycepin (0.1 mg/ml) or alpha-amanitin (10 micrograms/ml) partially inhibited insulin effects on ribosomes and protein synthesis but not on lipoprotein lipase.	cordycepin	0-10	insulin	Homo sapiens	80-87
226155-1	1979	The effect of cordycepin (3"-deoxyadenosine), an inhibitor of messenger RNA synthesis, on the induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase mediated by lipid-depleted serum was studied in isolated human lymphocytes.	cordycepin	14-24	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	107-154
6973358-0	1981	Density labelling characterisation of the effects of cordycepin and cycloheximide on the turnover of phenylalanine ammonia-lyase.	cordycepin	53-63	phenylalanine ammonia-lyase	Solanum tuberosum	101-128
6973358-4	1981	The effect of delayed treatment with cycloheximide or cordycepin on the turnover of phenylalanine ammonia-lyase has been analysed by density labelling with 2H from 2H2O.	cordycepin	54-64	phenylalanine ammonia-lyase	Solanum tuberosum	84-111
6973358-5	1981	Delayed introduction of cycloheximide or cordycepin reduces the rate of labelling of phenylalanine ammonia-lyase whilst preventing the decay in enzyme activity observed in controls not treated with inhibitor, and this labelling pattern cannot be accounted for by effects of cycloheximide or cordecypin on the labelling of amino acid pools.	cordycepin	41-51	phenylalanine ammonia-lyase	Solanum tuberosum	85-112
6973358-6	1981	It is concluded that delayed treatment with cycloheximide or cordycepin leads to the maintenance of high levels of phenylalanine ammonia-lyase by inhibition of the removal of active enzyme rather than by maintenance of high rates of enzyme synthesis.	cordycepin	61-71	phenylalanine ammonia-lyase	Solanum tuberosum	115-142
7193216-4	1980	Cordycepin and alpha-amanitin also prevent dexamethasone-mediated inhibition of PA in HuEL cells, indicating that the RNA whose synthesis must be prevented is of the mRNA class.	cordycepin	0-10	solute carrier family 30 member 9	Homo sapiens	86-90
226155-1	1979	The effect of cordycepin (3"-deoxyadenosine), an inhibitor of messenger RNA synthesis, on the induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase mediated by lipid-depleted serum was studied in isolated human lymphocytes.	cordycepin	26-43	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	107-154