PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31186660-3	2019	Mc-ME exhibited an antioxidative property by decreasing radical levels in HaCaT keratinocytes and a cytoprotective property in H2O2-damaged HaCaT cells, which was mediated by increasing the expression or activation of Kelch-like ECH-associated protein 1 (KEAP1), HO-1, p85/PI3K, and AKT.	mc-me	0-5	kelch like ECH associated protein 1	Homo sapiens	218-253
31186660-3	2019	Mc-ME exhibited an antioxidative property by decreasing radical levels in HaCaT keratinocytes and a cytoprotective property in H2O2-damaged HaCaT cells, which was mediated by increasing the expression or activation of Kelch-like ECH-associated protein 1 (KEAP1), HO-1, p85/PI3K, and AKT.	mc-me	0-5	kelch like ECH associated protein 1	Homo sapiens	255-260
31186660-4	2019	Mc-ME was also active against wrinkle formation by regulating the activity or expression of tissue remodeling factors such as elastase, type 1 collagen, and matrix metalloproteinase (MMP)-1 and -9 and tissue-protecting enzymes such as hemeoxygenase-1 (HO-1) and sirtuin 1 (SIRT1) in NIH3T3 fibroblasts and HaCaT cells, in addition to increasing the proliferation of HaCaT cells.	mc-me	0-5	sirtuin 1	Mus musculus	262-271
31186660-4	2019	Mc-ME was also active against wrinkle formation by regulating the activity or expression of tissue remodeling factors such as elastase, type 1 collagen, and matrix metalloproteinase (MMP)-1 and -9 and tissue-protecting enzymes such as hemeoxygenase-1 (HO-1) and sirtuin 1 (SIRT1) in NIH3T3 fibroblasts and HaCaT cells, in addition to increasing the proliferation of HaCaT cells.	mc-me	0-5	sirtuin 1	Mus musculus	273-278
31186660-3	2019	Mc-ME exhibited an antioxidative property by decreasing radical levels in HaCaT keratinocytes and a cytoprotective property in H2O2-damaged HaCaT cells, which was mediated by increasing the expression or activation of Kelch-like ECH-associated protein 1 (KEAP1), HO-1, p85/PI3K, and AKT.	mc-me	0-5	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	269-272
31186660-5	2019	Mc-ME also showed antidehydration properties by inducing the expression of natural moisturizing factors such as filaggrin (FLG), transglutaminase-1 (TGM-1), and hyaluronic acid synthase (HAS)-1, -2, and -3 in HaCaT cells.	mc-me	0-5	filaggrin	Homo sapiens	112-121
31186660-5	2019	Mc-ME also showed antidehydration properties by inducing the expression of natural moisturizing factors such as filaggrin (FLG), transglutaminase-1 (TGM-1), and hyaluronic acid synthase (HAS)-1, -2, and -3 in HaCaT cells.	mc-me	0-5	filaggrin	Homo sapiens	123-126
31186660-3	2019	Mc-ME exhibited an antioxidative property by decreasing radical levels in HaCaT keratinocytes and a cytoprotective property in H2O2-damaged HaCaT cells, which was mediated by increasing the expression or activation of Kelch-like ECH-associated protein 1 (KEAP1), HO-1, p85/PI3K, and AKT.	mc-me	0-5	AKT serine/threonine kinase 1	Homo sapiens	283-286
31186660-5	2019	Mc-ME also showed antidehydration properties by inducing the expression of natural moisturizing factors such as filaggrin (FLG), transglutaminase-1 (TGM-1), and hyaluronic acid synthase (HAS)-1, -2, and -3 in HaCaT cells.	mc-me	0-5	transglutaminase 1	Homo sapiens	129-147
31186660-5	2019	Mc-ME also showed antidehydration properties by inducing the expression of natural moisturizing factors such as filaggrin (FLG), transglutaminase-1 (TGM-1), and hyaluronic acid synthase (HAS)-1, -2, and -3 in HaCaT cells.	mc-me	0-5	transglutaminase 1	Homo sapiens	149-154
30415059-8	2019	RESULTS: At nontoxic concentrations, Mc-ME downregulated the release of nitric oxide (NO), the mRNA expression of inducible nitric oxide synthase (iNOS), and the mRNA expression of interleukin (IL)-1beta from LPS-activated RAW264.7 cells.	mc-me	37-42	nitric oxide synthase 2, inducible	Mus musculus	114-145
31186660-5	2019	Mc-ME also showed antidehydration properties by inducing the expression of natural moisturizing factors such as filaggrin (FLG), transglutaminase-1 (TGM-1), and hyaluronic acid synthase (HAS)-1, -2, and -3 in HaCaT cells.	mc-me	0-5	hyaluronan synthase 1	Homo sapiens	161-205
31186660-6	2019	Moreover, Mc-ME showed an antimelanogenic property by inhibiting the synthesis and secretion of melanin from B16F10 melanoma cells via suppression of tyrosinase activity.	mc-me	10-15	tyrosinase	Mus musculus	150-160
30415059-8	2019	RESULTS: At nontoxic concentrations, Mc-ME downregulated the release of nitric oxide (NO), the mRNA expression of inducible nitric oxide synthase (iNOS), and the mRNA expression of interleukin (IL)-1beta from LPS-activated RAW264.7 cells.	mc-me	37-42	nitric oxide synthase 2, inducible	Mus musculus	147-151
30415059-8	2019	RESULTS: At nontoxic concentrations, Mc-ME downregulated the release of nitric oxide (NO), the mRNA expression of inducible nitric oxide synthase (iNOS), and the mRNA expression of interleukin (IL)-1beta from LPS-activated RAW264.7 cells.	mc-me	37-42	interleukin 1 beta	Mus musculus	181-203
29463104-9	2018	Whole lysate immunoblotting assays, luciferase assays, and overexpression experiments suggested that transforming growth factor [Formula: see text]-activated kinase 1 (TAK1) is targeted by Mc-ME, thereby suppressing NF-[Formula: see text]B and AP-1 activity via downregulation of extracellular signal-regulated kinases (ERKs) and AKT.	mc-me	189-194	mitogen-activated protein kinase kinase kinase 7	Mus musculus	168-172
29463104-10	2018	These results strongly suggest that Mc-ME exerts its anti-inflammatory activity by reducing the action of TAK1, which also affects the activation of NF-[Formula: see text]B and AP-1.	mc-me	36-41	mitogen-activated protein kinase kinase kinase 7	Mus musculus	106-110