PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31072017-9	2019	The configuration inversion at C-13 results in weaker binding of 13alpha-estrone derivatives to the aromatase enzyme.	13alpha-estrone	65-80	homeobox C13	Homo sapiens	31-35
30498534-2	2018	Bromo regioisomers (2- or 4-) of 13alpha-estrone and its 3-benzyl or 3-methyl ether were reacted with diethyl phosphite or diphenylphosphine oxide using Pd(PPh3)4 as catalyst under microwave irradiation.	13alpha-estrone	33-48	caveolin 1	Homo sapiens	156-160
28694873-0	2017	Synthesis of novel 13alpha-estrone derivatives by Sonogashira coupling as potential 17beta-HSD1 inhibitors.	13alpha-estrone	19-34	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	84-95
27263437-1	2016	13alpha-Estrone derivatives containing various substituents on C-3 and C-17 were synthesized, and evaluated by means of MTT assays for in vitro antiproliferative activity against a panel of human adherent cancer cell lines (HeLa, MCF-7, A2780 and A431).	13alpha-estrone	0-15	complement C3	Homo sapiens	63-66
27263437-1	2016	13alpha-Estrone derivatives containing various substituents on C-3 and C-17 were synthesized, and evaluated by means of MTT assays for in vitro antiproliferative activity against a panel of human adherent cancer cell lines (HeLa, MCF-7, A2780 and A431).	13alpha-estrone	0-15	cytokine like 1	Homo sapiens	71-75
27424610-3	2016	13alpha-Estrone inhibited the enzyme activity effectively with an IC50 value of 1.2 muM, which indicates that enzyme affinity is similar to that of the natural estrone substrate.	13alpha-estrone	0-15	latexin	Homo sapiens	84-87
26476182-0	2015	Synthesis of A-ring halogenated 13alpha-estrone derivatives as potential 17beta-HSD1 inhibitors.	13alpha-estrone	32-47	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	73-84
25845933-1	2015	Novel 16-triazoles in the 13alpha-estrone series were synthesized via Cu(I)-catalyzed azide-alkyne cycloaddition of the two diastereomeric (on C-16 and on C-17) 16-azido-13alpha-estra-1,3,5(10)-trien-17-ol 3-benzyl ethers with substituted phenylacetylenes.	13alpha-estrone	26-41	cytokine like 1	Homo sapiens	155-159