PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24106697-3	2013	Thus, we designed this study with the aim to investigate the effect of sodium selenate, a protein tyrosine phosphatase (PTP) inhibitor, individually and as an adjunct to metformin, on a rat model that simulates the metabolic characteristics of human T2DM.	Selenic Acid	71-86	protein tyrosine phosphatase, non-receptor type 13	Rattus norvegicus	90-118
24106697-3	2013	Thus, we designed this study with the aim to investigate the effect of sodium selenate, a protein tyrosine phosphatase (PTP) inhibitor, individually and as an adjunct to metformin, on a rat model that simulates the metabolic characteristics of human T2DM.	Selenic Acid	71-86	protein tyrosine phosphatase, non-receptor type 13	Rattus norvegicus	120-123
22986308-4	2013	In the second step, selenate (SeO(4)(2-)) sensitivity was introduced by crossing the GSH2-deficient mutant with a strain harboring the met30 mutation.	Selenic Acid	20-28	glutathione synthase	Saccharomyces cerevisiae S288C	85-89
22366233-0	2012	Selenate enhances STAT3 transcriptional activity in endothelial cells: differential actions of selenate and selenite on LIF cytokine signaling and cell viability.	Selenic Acid	0-8	signal transducer and activator of transcription 3	Homo sapiens	18-23
22974981-0	2012	Selenate inhibits adipogenesis through induction of transforming growth factor-beta1 (TGF-beta1) signaling.	Selenic Acid	0-8	transforming growth factor beta 1	Homo sapiens	52-84
22974981-0	2012	Selenate inhibits adipogenesis through induction of transforming growth factor-beta1 (TGF-beta1) signaling.	Selenic Acid	0-8	transforming growth factor beta 1	Homo sapiens	86-95
22974981-6	2012	The effects of selenate on adipogenesis and cell morphology change were blunted by the treatment with SB431542, a specific inhibitor of transforming growth factor-beta1 (TGF-beta1) receptor, neutralization TGF-beta1 by its antibody, and knockdown of TGF-beta1 in preadipocytes, suggesting a requirement of TGF-beta signaling for the anti-adipogenic function of selenate.	Selenic Acid	15-23	transforming growth factor beta 1	Homo sapiens	136-168
22974981-6	2012	The effects of selenate on adipogenesis and cell morphology change were blunted by the treatment with SB431542, a specific inhibitor of transforming growth factor-beta1 (TGF-beta1) receptor, neutralization TGF-beta1 by its antibody, and knockdown of TGF-beta1 in preadipocytes, suggesting a requirement of TGF-beta signaling for the anti-adipogenic function of selenate.	Selenic Acid	15-23	transforming growth factor beta 1	Homo sapiens	170-179
22974981-6	2012	The effects of selenate on adipogenesis and cell morphology change were blunted by the treatment with SB431542, a specific inhibitor of transforming growth factor-beta1 (TGF-beta1) receptor, neutralization TGF-beta1 by its antibody, and knockdown of TGF-beta1 in preadipocytes, suggesting a requirement of TGF-beta signaling for the anti-adipogenic function of selenate.	Selenic Acid	15-23	transforming growth factor beta 1	Homo sapiens	206-215
22974981-6	2012	The effects of selenate on adipogenesis and cell morphology change were blunted by the treatment with SB431542, a specific inhibitor of transforming growth factor-beta1 (TGF-beta1) receptor, neutralization TGF-beta1 by its antibody, and knockdown of TGF-beta1 in preadipocytes, suggesting a requirement of TGF-beta signaling for the anti-adipogenic function of selenate.	Selenic Acid	15-23	transforming growth factor beta 1	Homo sapiens	206-215
22974981-6	2012	The effects of selenate on adipogenesis and cell morphology change were blunted by the treatment with SB431542, a specific inhibitor of transforming growth factor-beta1 (TGF-beta1) receptor, neutralization TGF-beta1 by its antibody, and knockdown of TGF-beta1 in preadipocytes, suggesting a requirement of TGF-beta signaling for the anti-adipogenic function of selenate.	Selenic Acid	15-23	transforming growth factor beta 1	Homo sapiens	170-178
22974981-7	2012	Among tested forms of selenium, selenate appears to be an effective activator of TGF-beta1 expression in preadipocytes.	Selenic Acid	32-40	transforming growth factor beta 1	Homo sapiens	81-90
22974981-8	2012	These results indicate that selenate is a novel dietary micromineral that activates TGF-beta1 signaling in preadipocytes and modulates adipogenesis.	Selenic Acid	28-36	transforming growth factor beta 1	Homo sapiens	84-93
23125459-8	2013	In INS-1 insulinoma cells, Sepp1 expression was stimulated by the selenium compound sodium selenate and diminished in the presence of high glucose (16.7 vs 5  mM) concentrations.	Selenic Acid	84-99	selenoprotein P	Rattus norvegicus	27-32
22565259-3	2012	Inhibition of selenate (SeO4) reduction in the presence of NO3 and the oxidation of reduced Se from shale by autotrophic denitrification were investigated.	Selenic Acid	14-22	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
22366233-0	2012	Selenate enhances STAT3 transcriptional activity in endothelial cells: differential actions of selenate and selenite on LIF cytokine signaling and cell viability.	Selenic Acid	95-103	LIF interleukin 6 family cytokine	Homo sapiens	120-123
22366233-2	2012	We report that treatment of human microvascular endothelial cells with sodium selenate at a pharmacological dose (100 muM) enhanced tyrosine phosphorylation of nuclear STAT3 on Y705 in response to IL-6-type cytokine, leukemia inhibitory factor (LIF), indicative of enhanced STAT3 activity.	Selenic Acid	71-86	latexin	Homo sapiens	118-121
22366233-2	2012	We report that treatment of human microvascular endothelial cells with sodium selenate at a pharmacological dose (100 muM) enhanced tyrosine phosphorylation of nuclear STAT3 on Y705 in response to IL-6-type cytokine, leukemia inhibitory factor (LIF), indicative of enhanced STAT3 activity.	Selenic Acid	71-86	signal transducer and activator of transcription 3	Homo sapiens	168-173
22366233-2	2012	We report that treatment of human microvascular endothelial cells with sodium selenate at a pharmacological dose (100 muM) enhanced tyrosine phosphorylation of nuclear STAT3 on Y705 in response to IL-6-type cytokine, leukemia inhibitory factor (LIF), indicative of enhanced STAT3 activity.	Selenic Acid	71-86	LIF interleukin 6 family cytokine	Homo sapiens	245-248
22366233-2	2012	We report that treatment of human microvascular endothelial cells with sodium selenate at a pharmacological dose (100 muM) enhanced tyrosine phosphorylation of nuclear STAT3 on Y705 in response to IL-6-type cytokine, leukemia inhibitory factor (LIF), indicative of enhanced STAT3 activity.	Selenic Acid	71-86	signal transducer and activator of transcription 3	Homo sapiens	274-279
22366233-5	2012	The enhancing action of selenate on LIF-induced STAT3 Y705 phosphorylation was replicated by vanadate and a specific inhibitor of protein tyrosine phosphatase, non-receptor type 1 (PTP1B).	Selenic Acid	24-32	LIF interleukin 6 family cytokine	Homo sapiens	36-39
22366233-5	2012	The enhancing action of selenate on LIF-induced STAT3 Y705 phosphorylation was replicated by vanadate and a specific inhibitor of protein tyrosine phosphatase, non-receptor type 1 (PTP1B).	Selenic Acid	24-32	signal transducer and activator of transcription 3	Homo sapiens	48-53
22366233-5	2012	The enhancing action of selenate on LIF-induced STAT3 Y705 phosphorylation was replicated by vanadate and a specific inhibitor of protein tyrosine phosphatase, non-receptor type 1 (PTP1B).	Selenic Acid	24-32	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	181-186
22182692-2	2012	Here we investigated whether treatment with sodium selenate, a drug which reduces pathological hyperphosphorylated tau by enhancement of PP2A activity, would inhibit seizures in rodent models.	Selenic Acid	44-59	protein phosphatase 2 phosphatase activator	Homo sapiens	137-141
22366233-6	2012	Moreover, we observed that selenite, the cellular reduction bioproduct of selenate but not selenate itself, inhibited enzymatic activity of human recombinant PTP1B.	Selenic Acid	74-82	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	158-163
22182692-3	2012	In vitro, sodium selenate reduced tau phosphorylation in human neuroblastoma cells and reversed the increase in tau phosphorylation induced by the PP2A inhibitor, okadaic acid.	Selenic Acid	10-25	protein phosphatase 2 phosphatase activator	Homo sapiens	147-151
21585336-0	2011	Adenosine 5"-phosphosulfate reductase (APR2) mutation in Arabidopsis implicates glutathione deficiency in selenate toxicity.	Selenic Acid	106-114	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	0-37
21585336-0	2011	Adenosine 5"-phosphosulfate reductase (APR2) mutation in Arabidopsis implicates glutathione deficiency in selenate toxicity.	Selenic Acid	106-114	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	39-43
21585336-4	2011	Sulfur metabolism was perturbed in apr2-1 plants grown on selenate, as observed by an increase in total sulfur and sulfate, and a 2-fold decrease in glutathione concentration.	Selenic Acid	58-66	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	35-39
21585336-5	2011	The altered sulfur metabolism in apr2-1 grown on selenate did not reflect typical sulfate starvation, as cysteine and methionine levels were increased.	Selenic Acid	49-57	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	33-37
21585336-6	2011	Knockout of APR2 also increased the accumulation of total selenium and selenate.	Selenic Acid	71-79	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	12-16
21585336-9	2011	However, because the apr2-1 mutant exhibited decreased tolerance to selenate, we propose that selenium toxicity can also be caused by selenate"s disruption of glutathione biosynthesis leading to enhanced levels of damaging ROS (reactive oxygen species).	Selenic Acid	68-76	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	21-25
21585336-9	2011	However, because the apr2-1 mutant exhibited decreased tolerance to selenate, we propose that selenium toxicity can also be caused by selenate"s disruption of glutathione biosynthesis leading to enhanced levels of damaging ROS (reactive oxygen species).	Selenic Acid	134-142	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	21-25
20537899-5	2010	We have determined that sodium selenate can act as a specific agonist for PP2A, significantly boosting phosphatase activity.	Selenic Acid	24-39	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	74-78
21246260-7	2011	Both doxycycline and sodium selenate prevented diabetes-induced decrease of TRX-1 levels in skeletal muscle, whereas only doxyxycline was effectively preventing diabetes-induced decrease of TRX-1 in liver.	Selenic Acid	21-36	thioredoxin 1	Rattus norvegicus	76-81
20174975-0	2011	Downregulation of apoptosis and modulation of TGF-beta1 by sodium selenate prevents streptozotocin-induced diabetic rat renal impairment.	Selenic Acid	59-74	transforming growth factor, beta 1	Rattus norvegicus	46-55
20174975-18	2011	Immunopositivity of TGF-beta1 was significantly reduced in both low and high dose of sodium-selenate-treated rats (P < 0.05, P < 0.01).	Selenic Acid	85-100	transforming growth factor, beta 1	Rattus norvegicus	20-29
20174975-20	2011	We conclude herein that sodium selenate has the potential to play a significant role in limiting the renal impairment by altering the apoptosis and TGF-beta1 in experimental diabetic rats.	Selenic Acid	24-39	transforming growth factor, beta 1	Rattus norvegicus	148-157
21246260-0	2011	Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity.	Selenic Acid	16-31	thioredoxin 1	Rattus norvegicus	88-101
21172326-0	2011	An in vitro comparison of a new vinyl chalcogenide and sodium selenate on adenosine deaminase activity of human leukocytes.	Selenic Acid	55-70	adenosine deaminase	Homo sapiens	74-93
20648008-0	2010	Open-label, phase I dose-escalation study of sodium selenate, a novel activator of PP2A, in patients with castration-resistant prostate cancer.	Selenic Acid	45-60	protein phosphatase 2 phosphatase activator	Homo sapiens	83-87
20648008-2	2010	Sodium selenate is a small, water-soluble, orally bioavailable activator of PP2A phosphatase with anti-angiogenic properties.	Selenic Acid	0-15	protein phosphatase 2 phosphatase activator	Homo sapiens	76-80
20537899-8	2010	Sodium selenate is a specific activator of PP2A with excellent oral bioavailability, and favourable central nervous system penetrating properties.	Selenic Acid	0-15	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	43-47
19040637-5	2009	We found that Grx1 and Grx2 are active, and that Grx2 but not Grx1 is crucial to tolerance to hydrogen peroxide and selenate.	Selenic Acid	116-124	glutaredoxin	Homo sapiens	14-18
20643941-8	2010	We found that selenate stabilizes PP2A-tau complexes.	Selenic Acid	14-22	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	34-38
20016929-6	2010	Biochemical data showed that sodium selenate treatment induced a significant regulation of MMP-2 activity and protein loss as well as normalization of increased levels of tissue nitrite and protein thiol oxidation.	Selenic Acid	29-44	matrix metallopeptidase 2	Rattus norvegicus	91-96
20016929-8	2010	Taken together, our data demonstrate that these beneficial effects of sodium selenate treatment in diabetics are related to be not only inhibition of increased oxidative stress but also prevention of both receptor- and smooth muscle-mediated dysfunction of vasculature, in part, via regulation of MMP-2.	Selenic Acid	70-85	matrix metallopeptidase 2	Rattus norvegicus	297-302
19330319-3	2009	Treatment with the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine or vitamin E could prevent the impairment in contractile responses of both ends to EFS and phenylephrine but sodium selenate could restore these impaired contractions at only the epididymal end.	Selenic Acid	192-207	nitric oxide synthase 2	Rattus norvegicus	19-50
19330319-3	2009	Treatment with the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine or vitamin E could prevent the impairment in contractile responses of both ends to EFS and phenylephrine but sodium selenate could restore these impaired contractions at only the epididymal end.	Selenic Acid	192-207	nitric oxide synthase 2	Rattus norvegicus	52-56
19330319-8	2009	The restorative effects of vitamin E and/or sodium selenate on this hypocontractility may depend on their antioxidant properties or their inhibitory action on the iNOS.	Selenic Acid	44-59	nitric oxide synthase 2	Rattus norvegicus	163-167
19656903-6	2009	Bacteria expressing BoCOQ5-2 produced an over 160-fold increase in volatile Se compounds when they were exposed to selenate.	Selenic Acid	115-123	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial	Brassica oleracea	20-28
19656903-7	2009	Consequently, the BoCOQ5-2-transformed bacteria had dramatically enhanced tolerance to selenate and a reduced level of Se accumulation.	Selenic Acid	87-95	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial	Brassica oleracea	18-26
19710230-1	2009	Selenium-Binding Protein1 (SBP1) gene expression was studied in Arabidopsis (Arabidopsis thaliana) seedlings challenged with several stresses, including cadmium (Cd), selenium {selenate [Se(VI)] and selenite [Se(IV)]}, copper (Cu), zinc (Zn), and hydrogen peroxide (H(2)O(2)) using transgenic lines expressing the luciferase (LUC) reporter gene under the control of the SBP1 promoter.	Selenic Acid	177-185	selenium-binding protein 1	Arabidopsis thaliana	27-31
19166293-7	2009	Therefore, the employment of selenate solutions at a concentration of 8 mg/L and germination for 5 days at 20 degrees C may be suggested for the production of Se-enriched lupin sprouts.	Selenic Acid	29-37	5'-nucleotidase, cytosolic IIIA	Homo sapiens	171-176
19040637-5	2009	We found that Grx1 and Grx2 are active, and that Grx2 but not Grx1 is crucial to tolerance to hydrogen peroxide and selenate.	Selenic Acid	116-124	glutaredoxin 2	Homo sapiens	49-53
19040637-6	2009	We also found that Synechocystis has no genuine glutathione reductase and uses NTR as a Grx electron donor, in a novel integrative pathway NADPH-NTR-Grx1-Grx2-Fed7 (ferredoxin 7), which operates in protection against selenate, the predominant form of selenium in the environment.	Selenic Acid	217-225	glutaredoxin	Homo sapiens	149-153
19040637-6	2009	We also found that Synechocystis has no genuine glutathione reductase and uses NTR as a Grx electron donor, in a novel integrative pathway NADPH-NTR-Grx1-Grx2-Fed7 (ferredoxin 7), which operates in protection against selenate, the predominant form of selenium in the environment.	Selenic Acid	217-225	glutaredoxin 2	Homo sapiens	154-158
18357617-7	2008	By the analysis of the embryo proper, actin-binding proteins were identified as proteins with quantitative changes by selenate: increased phosphorylated-cofilin 1, increased phosphorylated-destrin, decreased drebrin E, and decreased myosin light polypeptide 3.	Selenic Acid	118-126	cofilin 1	Rattus norvegicus	153-162
18357617-7	2008	By the analysis of the embryo proper, actin-binding proteins were identified as proteins with quantitative changes by selenate: increased phosphorylated-cofilin 1, increased phosphorylated-destrin, decreased drebrin E, and decreased myosin light polypeptide 3.	Selenic Acid	118-126	myosin light chain 3	Rattus norvegicus	233-259
18357617-8	2008	Many proteins showed similar changes between selenate and selenite, including increased ATP-synthase, decreased acidic ribosomal phosphoprotein P0, and decreased pyrroline-5-carboxylate reductase-like.	Selenic Acid	45-53	ribosomal protein lateral stalk subunit P0	Rattus norvegicus	112-146
18388974-5	2008	The cloned ATP sulphurylase gene (sua1) proved to be an efficient selection marker in an ARS vector, when different isogenic or nonisogenic S. pombe selenate-resistant mutants were used as cloning hosts.	Selenic Acid	149-157	Nmd2p	Saccharomyces cerevisiae S288C	34-38
17208959-2	2007	Screening an Arabidopsis (Arabidopsis thaliana) T-DNA mutant library for selenate resistance enabled us to isolate a selenate-resistant mutant line (sel1-11).	Selenic Acid	73-81	sulfate transporter 1;2	Arabidopsis thaliana	149-153
17208959-2	2007	Screening an Arabidopsis (Arabidopsis thaliana) T-DNA mutant library for selenate resistance enabled us to isolate a selenate-resistant mutant line (sel1-11).	Selenic Acid	117-125	sulfate transporter 1;2	Arabidopsis thaliana	149-153
17208959-5	2007	The selenate resistance phenotype of the sel1-11 mutant was mirrored by an 8-fold increase of root growth in the presence of selenate as shown by the calculated lethal concentration values.	Selenic Acid	4-12	sulfate transporter 1;2	Arabidopsis thaliana	41-48
17208959-5	2007	The selenate resistance phenotype of the sel1-11 mutant was mirrored by an 8-fold increase of root growth in the presence of selenate as shown by the calculated lethal concentration values.	Selenic Acid	125-133	sulfate transporter 1;2	Arabidopsis thaliana	41-48
17208959-8	2007	Roots of the sel1-11 mutant line showed a higher sulfate to selenate ratio than that of wild-type roots, while there were no significant differences in sulfate to selenate ratios in shoots of wild-type and mutant lines.	Selenic Acid	60-68	sulfate transporter 1;2	Arabidopsis thaliana	13-17
17208959-9	2007	These results indicated that the mechanism that confers the selenate resistance phenotype to the sel1-11 line takes place rather in the roots.	Selenic Acid	60-68	sulfate transporter 1;2	Arabidopsis thaliana	97-101
17208959-11	2007	These results revealed in plants a central and specific role of the transporter SULTR1;2 in selenate sensitivity; they further suggested that root growth and potentially the root tip activity might be a specific target of selenate toxicity in Arabidopsis.	Selenic Acid	92-100	sulfate transporter 1;2	Arabidopsis thaliana	80-88
17208959-11	2007	These results revealed in plants a central and specific role of the transporter SULTR1;2 in selenate sensitivity; they further suggested that root growth and potentially the root tip activity might be a specific target of selenate toxicity in Arabidopsis.	Selenic Acid	222-230	sulfate transporter 1;2	Arabidopsis thaliana	80-88
16244144-6	2005	Also, sulfur accumulation was enhanced by approximately 30% in CpNifS overexpressors, both on media with and without selenate.	Selenic Acid	117-125	chloroplastic NIFS-like cysteine desulfurase	Arabidopsis thaliana	63-69
16443359-10	2006	Selenate treatment reduced insulin resistance significantly and reduced the activity of liver cytosolic protein tyrosine phosphatases (PTPs) as negative regulators of insulin signalling by about 50%.	Selenic Acid	0-8	6-pyruvoyl-tetrahydropterin synthase	Mus musculus	135-139
16443359-14	2006	The expression of peroxisome proliferator-activated receptor gamma (PPARgamma), another important factor in the context of insulin resistance and lipid metabolism, was significantly increased by selenate application.	Selenic Acid	195-203	peroxisome proliferator activated receptor gamma	Mus musculus	18-66
16443359-14	2006	The expression of peroxisome proliferator-activated receptor gamma (PPARgamma), another important factor in the context of insulin resistance and lipid metabolism, was significantly increased by selenate application.	Selenic Acid	195-203	peroxisome proliferator activated receptor gamma	Mus musculus	68-77
16443359-16	2006	In conclusion, our results showed that supranutritional selenate doses influenced two important mechanisms involved in insulin-resistant diabetes, namely, PTPs and PPARgamma, which, in turn, can be assumed as being responsible for the changes in intermediary metabolism, e.g., gluconeogenesis and lipid metabolism.	Selenic Acid	56-64	6-pyruvoyl-tetrahydropterin synthase	Mus musculus	155-159
16443359-16	2006	In conclusion, our results showed that supranutritional selenate doses influenced two important mechanisms involved in insulin-resistant diabetes, namely, PTPs and PPARgamma, which, in turn, can be assumed as being responsible for the changes in intermediary metabolism, e.g., gluconeogenesis and lipid metabolism.	Selenic Acid	56-64	peroxisome proliferator activated receptor gamma	Mus musculus	164-173
16211368-3	2006	Two of the transporters, NaS1 and NaS2, carry substrates such as sulfate, selenate and thiosulfate.	Selenic Acid	74-82	solute carrier family 13 member 1	Homo sapiens	25-29
16211368-3	2006	Two of the transporters, NaS1 and NaS2, carry substrates such as sulfate, selenate and thiosulfate.	Selenic Acid	74-82	solute carrier family 13 member 4	Homo sapiens	34-38
16539601-3	2006	The selenate tolerance index (TI(D10) = root growth + 30 microm selenate/root growth control x 100%) was fourfold higher for parental line Col-4 (59%) than for parent Ler-0 (15%).	Selenic Acid	4-12	zinc finger CONSTANS-like protein	Arabidopsis thaliana	139-144
16244144-9	2005	Judged from x-ray analysis of near edge spectrum, both CpNifS overexpressors and wild type accumulated mostly selenate (Se(VI)).	Selenic Acid	110-118	chloroplastic NIFS-like cysteine desulfurase	Arabidopsis thaliana	55-61
15863700-9	2005	Examination of BoSMT gene expression and SeMSC accumulation in response to selenate, selenite, and sulfate treatments showed that the BoSMT transcript and SeMSC synthesis were significantly up-regulated in plants exposed to selenate but were low in plants supplied with selenite.	Selenic Acid	75-83	selenocysteine Se-methyltransferase	Brassica oleracea	15-20
15941393-5	2005	Transgenic Arabidopsis thaliana overexpressing both ATPS and APR had a significant enhancement of selenate reduction as a proportion of total Se, whereas SAT overexpression resulted in only a slight increase in selenate reduction to organic forms.	Selenic Acid	98-106	APS reductase 1	Arabidopsis thaliana	61-64
15941393-7	2005	Root growth was adversely affected by selenate treatment in both ATPS and SAT overexpressors and less so in the PaAPR transgenic plants.	Selenic Acid	38-46	serine acetyltransferase 2;1	Arabidopsis thaliana	74-77
15941393-8	2005	Such observations support our conclusions that ATPS and APR are major contributors of selenate reduction in planta.	Selenic Acid	86-94	APS reductase 1	Arabidopsis thaliana	56-59
15863700-9	2005	Examination of BoSMT gene expression and SeMSC accumulation in response to selenate, selenite, and sulfate treatments showed that the BoSMT transcript and SeMSC synthesis were significantly up-regulated in plants exposed to selenate but were low in plants supplied with selenite.	Selenic Acid	75-83	selenocysteine Se-methyltransferase	Brassica oleracea	134-139
15065880-12	2004	Selenate, chromate, and arsenate produce transient APX intermediates that are sufficiently long-lived to be captured and 3"-phosphorylated by APS kinase.	Selenic Acid	0-8	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	51-54
15607730-3	2005	Expression of hNaS2 protein in Xenopus oocytes led to a Na(+)-dependent transport of sulfate that was inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate, but not by oxalate, citrate, succinate, phenol red or DIDS.	Selenic Acid	150-158	solute carrier family 13 member 4	Homo sapiens	14-19
15787978-5	2005	The activity of cytosolic protein tyrosine phosphatases (PTPs) as important negative regulators of insulin signalling was reduced from 53.8% to 22.5% in the liver and skeletal muscle of selenate-treated mice in comparison with the selenium deficient and selenite-treated controls, suggesting an inhibition of PTPs by intermediary selenate metabolites.	Selenic Acid	186-194	6-pyruvoyl-tetrahydropterin synthase	Mus musculus	57-61
15787978-5	2005	The activity of cytosolic protein tyrosine phosphatases (PTPs) as important negative regulators of insulin signalling was reduced from 53.8% to 22.5% in the liver and skeletal muscle of selenate-treated mice in comparison with the selenium deficient and selenite-treated controls, suggesting an inhibition of PTPs by intermediary selenate metabolites.	Selenic Acid	186-194	6-pyruvoyl-tetrahydropterin synthase	Mus musculus	309-313
15787978-5	2005	The activity of cytosolic protein tyrosine phosphatases (PTPs) as important negative regulators of insulin signalling was reduced from 53.8% to 22.5% in the liver and skeletal muscle of selenate-treated mice in comparison with the selenium deficient and selenite-treated controls, suggesting an inhibition of PTPs by intermediary selenate metabolites.	Selenic Acid	330-338	6-pyruvoyl-tetrahydropterin synthase	Mus musculus	57-61
15787978-8	2005	In conclusion, the results of the present study show that one possible mechanism by which supranutritional selenate doses enhance insulin sensitivity in type II diabetic dbdb mice is based on the inhibition of PTPS as negative regulators of insulin signalling.	Selenic Acid	107-115	6-pyruvoyl-tetrahydropterin synthase	Mus musculus	210-214
12805590-5	2003	This mutant, sel1-10, is allelic with the sel1 mutants identified previously in a screen for increased tolerance to selenate, a toxic analog of sulfate (Shibagaki et al., 2002).	Selenic Acid	116-124	sulfate transporter 1;2	Arabidopsis thaliana	13-20
14629895-6	2003	In contrast selenate treatment (SeVI) repressed the activity of liver pyruvate carboxylase the first enzyme in gluconeogenesis by about 33% in comparison to the selenium deficient (0Se) and selenite treated mice (SeIV).	Selenic Acid	12-20	pyruvate carboxylase	Mus musculus	70-90
12805590-5	2003	This mutant, sel1-10, is allelic with the sel1 mutants identified previously in a screen for increased tolerance to selenate, a toxic analog of sulfate (Shibagaki et al., 2002).	Selenic Acid	116-124	sulfate transporter 1;2	Arabidopsis thaliana	13-17
9546621-6	1998	Rapamycin, a specific inhibitor of the p70s6k isoform of S6 kinase, partially reduced the activation of S6 kinase activity by sodium selenate, indicating a role for this kinase in the overall activity of the S6 kinase in sodium selenate-treated cells.	Selenic Acid	126-141	ribosomal protein S6 kinase B1	Rattus norvegicus	39-45
11846879-7	2002	Addition of selenate to the medium increased the level of Sultr1;1 mRNA in parallel with a decrease in the internal sulfate pool in roots.	Selenic Acid	12-20	sulfate transporter 1;1	Arabidopsis thaliana	58-66
11846879-9	2002	Antisense plants of Sultr1;1 showed reduced accumulation of sulfate in roots, particularly in plants treated with selenate, suggesting that the inducible transporter Sultr1;1 contributes to the uptake of sulfate under stressed conditions.	Selenic Acid	114-122	sulfate transporter 1;1	Arabidopsis thaliana	20-28
11846879-9	2002	Antisense plants of Sultr1;1 showed reduced accumulation of sulfate in roots, particularly in plants treated with selenate, suggesting that the inducible transporter Sultr1;1 contributes to the uptake of sulfate under stressed conditions.	Selenic Acid	114-122	sulfate transporter 1;1	Arabidopsis thaliana	166-174
11846880-0	2002	Selenate-resistant mutants of Arabidopsis thaliana identify Sultr1;2, a sulfate transporter required for efficient transport of sulfate into roots.	Selenic Acid	0-8	sulfate transporter 1;2	Arabidopsis thaliana	60-68
11846880-0	2002	Selenate-resistant mutants of Arabidopsis thaliana identify Sultr1;2, a sulfate transporter required for efficient transport of sulfate into roots.	Selenic Acid	0-8	sulfate transporter 1;2	Arabidopsis thaliana	72-91
11846880-3	2002	They are allelic to each other and to the previously isolated sel1 (selenate-resistant) mutants, and have been designated sel1-8 and sel1-9.	Selenic Acid	68-76	sulfate transporter 1;2	Arabidopsis thaliana	62-66
11846880-3	2002	They are allelic to each other and to the previously isolated sel1 (selenate-resistant) mutants, and have been designated sel1-8 and sel1-9.	Selenic Acid	68-76	sulfate transporter 1;2	Arabidopsis thaliana	122-128
11846880-3	2002	They are allelic to each other and to the previously isolated sel1 (selenate-resistant) mutants, and have been designated sel1-8 and sel1-9.	Selenic Acid	68-76	sulfate transporter 1;2	Arabidopsis thaliana	133-139
11161786-5	2000	Expression of hNaSi-1 protein in Xenopus oocytes demonstrated a high-affinity Na+-sulfate cotransporter that was inhibited by selenate, thiosulfate, molybdate, tungstate, citrate, and succinate.	Selenic Acid	126-134	solute carrier family 13 member 1	Homo sapiens	14-21
11964252-4	2002	PNU145156E binds to the heparin and the selenate-binding sites on bFGF.	Selenic Acid	40-48	fibroblast growth factor 2	Homo sapiens	66-70
12020427-11	2002	FPG incubation produced significantly larger increases in the SSB yield after gamma-irradiation in the additional presence of selenate and/or biselenite.	Selenic Acid	126-134	single-stranded DNA-binding protein	Escherichia coli	62-65
10929111-8	2000	Addition of selenate in the sulphate-sufficient medium increased the sulphate uptake capacity, tissue sulphate content and the abundance of Sultr1;1 and Sultr2;1 mRNA in roots.	Selenic Acid	12-20	sulfate transporter 1;1	Arabidopsis thaliana	140-161
10409492-7	1999	NaSi-1 specificity for the Na(+) cation was determined, and the anions selenate, molybdate, tungstate, oxalate and thiosulphate could all inhibit NaSi-1-induced sulphate transport.	Selenic Acid	71-79	solute carrier family 13 member 1 S homeolog	Xenopus laevis	146-152
9546621-6	1998	Rapamycin, a specific inhibitor of the p70s6k isoform of S6 kinase, partially reduced the activation of S6 kinase activity by sodium selenate, indicating a role for this kinase in the overall activity of the S6 kinase in sodium selenate-treated cells.	Selenic Acid	126-141	ribosomal protein S6 kinase B1	Rattus norvegicus	57-66
9546621-6	1998	Rapamycin, a specific inhibitor of the p70s6k isoform of S6 kinase, partially reduced the activation of S6 kinase activity by sodium selenate, indicating a role for this kinase in the overall activity of the S6 kinase in sodium selenate-treated cells.	Selenic Acid	126-141	ribosomal protein S6 kinase B1	Rattus norvegicus	104-113
9546621-6	1998	Rapamycin, a specific inhibitor of the p70s6k isoform of S6 kinase, partially reduced the activation of S6 kinase activity by sodium selenate, indicating a role for this kinase in the overall activity of the S6 kinase in sodium selenate-treated cells.	Selenic Acid	126-141	ribosomal protein S6 kinase B1	Rattus norvegicus	104-113
9546621-6	1998	Rapamycin, a specific inhibitor of the p70s6k isoform of S6 kinase, partially reduced the activation of S6 kinase activity by sodium selenate, indicating a role for this kinase in the overall activity of the S6 kinase in sodium selenate-treated cells.	Selenic Acid	221-236	ribosomal protein S6 kinase B1	Rattus norvegicus	39-45
9546621-6	1998	Rapamycin, a specific inhibitor of the p70s6k isoform of S6 kinase, partially reduced the activation of S6 kinase activity by sodium selenate, indicating a role for this kinase in the overall activity of the S6 kinase in sodium selenate-treated cells.	Selenic Acid	221-236	ribosomal protein S6 kinase B1	Rattus norvegicus	57-66
9546621-6	1998	Rapamycin, a specific inhibitor of the p70s6k isoform of S6 kinase, partially reduced the activation of S6 kinase activity by sodium selenate, indicating a role for this kinase in the overall activity of the S6 kinase in sodium selenate-treated cells.	Selenic Acid	221-236	ribosomal protein S6 kinase B1	Rattus norvegicus	104-113
9546621-6	1998	Rapamycin, a specific inhibitor of the p70s6k isoform of S6 kinase, partially reduced the activation of S6 kinase activity by sodium selenate, indicating a role for this kinase in the overall activity of the S6 kinase in sodium selenate-treated cells.	Selenic Acid	221-236	ribosomal protein S6 kinase B1	Rattus norvegicus	104-113
9315320-7	1997	Selenate is reduced by Grx and Trx in the presence of GSH.	Selenic Acid	0-8	glutaredoxin	Homo sapiens	23-26
9315320-7	1997	Selenate is reduced by Grx and Trx in the presence of GSH.	Selenic Acid	0-8	thioredoxin	Homo sapiens	31-34
8813134-7	1996	Selenite, in contrast to selenate, is efficiently reduced by the thioredoxin system (thioredoxin, thioredoxin reductase, and NADPH).	Selenic Acid	25-33	thioredoxin	Homo sapiens	65-76
9060997-7	1997	Using an in-gel activity assay for MAP kinase, we demonstrated that both the p42 and p44 MAP kinases are activated when either hepatocytes or adipocytes are incubated in the presence of selenate.	Selenic Acid	186-194	mitogen activated protein kinase 3	Rattus norvegicus	85-88
7690291-1	1993	Sodium selenate (selenate), as well as insulin, increased the lipoprotein lipase (LPL) activity in isolated rat fat pads in a time- and dose-dependent manner.	Selenic Acid	0-15	lipoprotein lipase	Rattus norvegicus	62-80
8834772-0	1995	Insulin-like effects of vanadate and selenate on the expression of glucose-6-phosphate dehydrogenase and fatty acid synthase in diabetic rats.	Selenic Acid	37-45	glucose-6-phosphate dehydrogenase	Rattus norvegicus	67-100
8834772-0	1995	Insulin-like effects of vanadate and selenate on the expression of glucose-6-phosphate dehydrogenase and fatty acid synthase in diabetic rats.	Selenic Acid	37-45	fatty acid synthase	Rattus norvegicus	105-124
8834772-5	1995	In this study we show that administration of vanadate or selenate to streptozotocin-induced diabetic rats not only normalizes blood glucose levels similarly to insulin but also positively affects the expression of two key metabolic enzymes, glucose-6-phosphate dehydrogenase (G6PDH) and fatty acid synthase (FAS).	Selenic Acid	57-65	glucose-6-phosphate dehydrogenase	Rattus norvegicus	241-274
8834772-5	1995	In this study we show that administration of vanadate or selenate to streptozotocin-induced diabetic rats not only normalizes blood glucose levels similarly to insulin but also positively affects the expression of two key metabolic enzymes, glucose-6-phosphate dehydrogenase (G6PDH) and fatty acid synthase (FAS).	Selenic Acid	57-65	glucose-6-phosphate dehydrogenase	Rattus norvegicus	276-281
8834772-5	1995	In this study we show that administration of vanadate or selenate to streptozotocin-induced diabetic rats not only normalizes blood glucose levels similarly to insulin but also positively affects the expression of two key metabolic enzymes, glucose-6-phosphate dehydrogenase (G6PDH) and fatty acid synthase (FAS).	Selenic Acid	57-65	fatty acid synthase	Rattus norvegicus	287-306
8834772-5	1995	In this study we show that administration of vanadate or selenate to streptozotocin-induced diabetic rats not only normalizes blood glucose levels similarly to insulin but also positively affects the expression of two key metabolic enzymes, glucose-6-phosphate dehydrogenase (G6PDH) and fatty acid synthase (FAS).	Selenic Acid	57-65	fatty acid synthase	Rattus norvegicus	308-311
7662504-7	1995	Type II 5"-deiodinase activity in brain was significantly higher in the methionine-deficient rats than in the methionine-sufficient rats fed selenium-sufficient diet as sodium selenate.	Selenic Acid	169-184	iodothyronine deiodinase 2	Rattus norvegicus	0-21
7945243-0	1994	Zinc, vanadate and selenate inhibit the tri-iodothyronine-induced expression of fatty acid synthase and malic enzyme in chick-embryo hepatocytes in culture.	Selenic Acid	19-27	fatty acid synthase	Gallus gallus	80-99
7945243-5	1994	Several recent studies have compared the effects of zinc, vanadate and selenate on insulin-sensitive processes in an attempt to probe the mechanism of insulin action.	Selenic Acid	71-79	insulin	Gallus gallus	83-90
7945243-6	1994	Because zinc, vanadate and selenate mimic the effects of insulin on several processes, they have been termed insulin-mimetics.	Selenic Acid	27-35	insulin	Gallus gallus	57-64
7945243-6	1994	Because zinc, vanadate and selenate mimic the effects of insulin on several processes, they have been termed insulin-mimetics.	Selenic Acid	27-35	insulin	Gallus gallus	109-116
7945243-7	1994	We have studied the effect of zinc, vanadate and selenate on the T3-induced expression of both FAS and ME.	Selenic Acid	49-57	fatty acid synthase	Gallus gallus	95-98
7945243-8	1994	Like insulin, these agents had little or no effect on the basal activities for FAS and ME in chick-embryo hepatocytes in culture for 48 h. Unlike insulin, however, zinc, vanadate and selenate inhibited the T3-induced activities and mRNA levels of both FAS and ME.	Selenic Acid	183-191	fatty acid synthase	Gallus gallus	252-255
7690291-1	1993	Sodium selenate (selenate), as well as insulin, increased the lipoprotein lipase (LPL) activity in isolated rat fat pads in a time- and dose-dependent manner.	Selenic Acid	0-15	lipoprotein lipase	Rattus norvegicus	82-85
7690291-1	1993	Sodium selenate (selenate), as well as insulin, increased the lipoprotein lipase (LPL) activity in isolated rat fat pads in a time- and dose-dependent manner.	Selenic Acid	7-15	lipoprotein lipase	Rattus norvegicus	62-80
7690291-1	1993	Sodium selenate (selenate), as well as insulin, increased the lipoprotein lipase (LPL) activity in isolated rat fat pads in a time- and dose-dependent manner.	Selenic Acid	7-15	lipoprotein lipase	Rattus norvegicus	82-85
7690291-6	1993	Dibutyryl cyclic AMP, 3-isobutyl-1-methylxanthine, carbonyl cyanide m-chlorophenylhydrazone, tunicamycin, and monensin all inhibited the increase effect of selenate on the LPL activity to various extents.	Selenic Acid	156-164	lipoprotein lipase	Rattus norvegicus	172-175
7690291-7	1993	These results suggest that selenate increases the LPL activity via amiloride- and monensin-sensitive processes, involving the Ca2+ mobilization linked to a rapid increase in the IP3 content in fat pads.	Selenic Acid	27-35	lipoprotein lipase	Rattus norvegicus	50-53
34988458-1	2021	Introduction: Sodium selenate is a potential disease-modifying treatment for Alzheimer"s disease (AD) which reduces hyperphosphorylated tau through activation of the protein phosphatase 2A enzyme.	Selenic Acid	14-29	microtubule associated protein tau	Homo sapiens	136-139
2037562-2	1991	In rats maintained on a defined diet containing nutritionally adequate amounts of selenate as the sole selenium source, over half the selenium in plasma is accounted for by selenoprotein P.	Selenic Acid	82-90	selenoprotein P	Rattus norvegicus	173-188
1644202-0	1992	Enhancement of epidermal growth factor (EGF) and insulin-stimulated tyrosine phosphorylation of endogenous substrates by sodium selenate.	Selenic Acid	121-136	epidermal growth factor	Mus musculus	15-38
1644202-0	1992	Enhancement of epidermal growth factor (EGF) and insulin-stimulated tyrosine phosphorylation of endogenous substrates by sodium selenate.	Selenic Acid	121-136	epidermal growth factor	Mus musculus	40-43
1644202-1	1992	Sodium selenate stimulated tyrosine phosphorylation of the epidermal growth factor (EGF) receptor in A431 cells and enhanced the tyrosine phosphorylation of endogenous proteins in response to EGF in A431 cells and insulin in NIH 3T3 HIR3.5 cells.	Selenic Acid	0-15	epidermal growth factor receptor	Mus musculus	59-97
1644202-1	1992	Sodium selenate stimulated tyrosine phosphorylation of the epidermal growth factor (EGF) receptor in A431 cells and enhanced the tyrosine phosphorylation of endogenous proteins in response to EGF in A431 cells and insulin in NIH 3T3 HIR3.5 cells.	Selenic Acid	0-15	epidermal growth factor	Mus musculus	84-87
1702670-0	1990	An interaction between selenate and a sulfate transporter in the lactating rat mammary gland.	Selenic Acid	23-31	solute carrier family 26 member 2	Rattus norvegicus	38-57
2153102-3	1990	In the presence of insulin, selenate enhances insulin receptor kinase activity and phosphorylations of insulin-stimulated tyrosyl phosphoproteins.	Selenic Acid	28-36	insulin receptor	Rattus norvegicus	46-62
33032220-1	2021	It has not been well understood that the influences of pH and accompanying anions on the toxicity of selenate (Se(VI)).	Selenic Acid	101-109	phenylalanine hydroxylase	Homo sapiens	55-57
34628253-6	2022	The introduction of SeO42- or SO42- enriched selenate/sulfate-reducing bacteria (SeRB/SRB) but decreased the abundance of chromate-reducing bacteria (CRB).	Selenic Acid	45-53	chaperonin containing TCP1 subunit 4	Homo sapiens	86-89
34329094-2	2021	The microbial community of the granular sludge was first enriched for 140 days in the presence of Pb(II) only, selenate and selenite only, Pb(II)+selenate, and Pb(II)+selenite.	Selenic Acid	146-154	submaxillary gland androgen regulated protein 3B	Homo sapiens	139-145
34329094-5	2021	Addition of Pb(II) didn"t exert any toxic effect on the Se-reducing microbial community, on the contrary: Pb(II) addition improved the Se removal efficiency for selenate from 85% to 90%, but did not affect selenite removal after 14 d of incubation.	Selenic Acid	161-169	submaxillary gland androgen regulated protein 3B	Homo sapiens	12-18
34329094-5	2021	Addition of Pb(II) didn"t exert any toxic effect on the Se-reducing microbial community, on the contrary: Pb(II) addition improved the Se removal efficiency for selenate from 85% to 90%, but did not affect selenite removal after 14 d of incubation.	Selenic Acid	161-169	submaxillary gland androgen regulated protein 3B	Homo sapiens	106-112
35574563-1	2022	Introduction: Sodium selenate increases tau dephosphorylation through protein phosphatase 2 activation.	Selenic Acid	14-29	microtubule associated protein tau	Homo sapiens	40-43
2852259-3	1988	The equilibrium dissociation constants of the binding of sulfate (Kd = 0.12 microM) and selenate (Kd = 5 microM) were found to be pH independent over the range pH 5 to pH 8.1, whereas chromate binding exhibited a pH dependence that is approximately attributable to the pK2 of the chromic acid.	Selenic Acid	88-96	prokineticin 2	Homo sapiens	269-272
35084469-4	2022	Notably, the application of selenate positively induced the S-starvation transcript markers: low-sulfur-induced1 (LSU1), LSU2 and ChaC like protein.	Selenic Acid	28-36	response to low sulfur 1	Arabidopsis thaliana	114-118
35084469-4	2022	Notably, the application of selenate positively induced the S-starvation transcript markers: low-sulfur-induced1 (LSU1), LSU2 and ChaC like protein.	Selenic Acid	28-36	response to low sulfur 2	Arabidopsis thaliana	121-125
27045899-5	2018	This deficiency was addressed by monitoring selenate-treated Arabidopsis plants with mutations in HRD1 and SeL1L, participants of ERAD.	Selenic Acid	44-52	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase	Homo sapiens	107-112
33962229-8	2021	Foliar Se application at the concentration 50 g ha-1 applied as sodium selenate increases the antioxidant, photosynthetic metabolism, and yield of several crops.	Selenic Acid	64-79	Rho GTPase activating protein 45	Homo sapiens	48-52
31928671-6	2020	In response to abiotic stress, DALL3 was shown to participate in the network of genes regulated by cadmium, selenite and selenate compounds.	Selenic Acid	121-129	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	31-36
30942158-11	2019	Our results findings suggest that the combination of Vit C, Vit E, beta-carotene, sodium selenate and ranitidine has a protective effect on indomethacin-induced gastric mucosal injury of rats.	Selenic Acid	82-97	vitrin	Rattus norvegicus	53-56
30781361-0	2019	The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3betaY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neurons.	Selenic Acid	21-36	protein phosphatase 2 phosphatase activator	Homo sapiens	58-62
30781361-1	2019	Selenium application as sodium selenate was repeatedly shown to have anti-carcinogenic properties by increasing levels of the serine/ threonine protein phosphatase 2A (PP2A) in cancer cells.	Selenic Acid	24-39	protein phosphatase 2 phosphatase activator	Homo sapiens	168-172
30781361-4	2019	In this study we recorded maximum increase in total PP2A at 3 microM sodium selenate in a neuron cell line.	Selenic Acid	69-84	protein phosphatase 2 phosphatase activator	Homo sapiens	52-56
30781361-8	2019	In summary, our data reveal that sodium selenate enhances PP2A levels, but reduces catalytic activity of PP2A in a dose dependent manner, which fails to reduce Tau and GSK3beta phosphorylation under physiological conditions, indicating an alternative route in the rescue of cell pathology in neurological disorders.	Selenic Acid	33-48	protein phosphatase 2 phosphatase activator	Homo sapiens	58-62
30781361-8	2019	In summary, our data reveal that sodium selenate enhances PP2A levels, but reduces catalytic activity of PP2A in a dose dependent manner, which fails to reduce Tau and GSK3beta phosphorylation under physiological conditions, indicating an alternative route in the rescue of cell pathology in neurological disorders.	Selenic Acid	33-48	protein phosphatase 2 phosphatase activator	Homo sapiens	105-109
30400605-0	2018	Selenate Prevents Adipogenesis through Induction of Selenoprotein S and Attenuation of Endoplasmic Reticulum Stress.	Selenic Acid	0-8	selenoprotein S	Homo sapiens	52-67
30400605-8	2018	The expression of the adipogenic genes peroxisome proliferator-activated receptor gamma, CCAAT-enhancer binding protein alpha, and leptin was suppressed by selenate.	Selenic Acid	156-164	CCAAT enhancer binding protein alpha	Homo sapiens	89-125
30400605-11	2018	The expression of the ER stress marker genes was upregulated during the early stage of differentiation, whereas the selenate pretreatment suppressed the mRNA expression of the XBP1 and C/EBP homologous protein.	Selenic Acid	116-124	X-box binding protein 1	Homo sapiens	176-180
3761002-11	1986	Adding sodium selenate to increase the total nonradioactive Se of human milk, bovine milk (endogenous plus the added selenium) did not affect the absorption of either [75Se]selenomethionine or [75Se]selenite.	Selenic Acid	7-22	Weaning weight-maternal milk	Bos taurus	72-76
6589161-0	1984	Differences in the binding of sulfate, selenate and thiosulfate ions to bovine liver rhodanese, and a description of a binding site for ammonium and sodium ions.	Selenic Acid	39-47	thiosulfate sulfurtransferase	Bos taurus	85-94
6589161-2	1984	The binding of sulfate, selenate and thiosulfate by the sulfur-transferase rhodanese (EC 2.8.1.1) in the crystalline state has been studied by X-ray analysis at resolutions between 0.23 nm and 0.4 nm.	Selenic Acid	24-32	thiosulfate sulfurtransferase	Bos taurus	75-84
6846235-4	1983	Platelet glutathione peroxidase (GSH-Px) activities increased rapidly in the wheat and selenate groups for 4 wk and then plateaued.	Selenic Acid	87-95	probable phospholipid hydroperoxide glutathione peroxidase	Triticum aestivum	9-31
79528-0	1978	Activity of lysosomal beta-glucuronidase in leukocytes of rats exposed to benzene and sodium selenate.	Selenic Acid	86-101	glucuronidase, beta	Rattus norvegicus	22-40
79528-2	1978	Administration of selenium (sodium selenate) in dosis of 1.0 microgram/Kg during consecutive 10 days prior the exposure to benzene resulted in prevention of benzene-induced decrease of the BG activity in granulocytes and of a damage to lymphocyte lysosomes.	Selenic Acid	28-43	glucuronidase, beta	Rattus norvegicus	189-191
33199422-2	2020	Previous work by our group has shown sodium selenate upregulates the activity of protein phosphatase 2 in the brain, increasing the rate of tau dephosphorylation.	Selenic Acid	37-52	microtubule associated protein tau	Homo sapiens	140-143
32138548-4	2020	Dissolved selenate was separated from dissolved selenite, carbonate, phosphate, and arsenate by addition of Ce3+ cations that quantitatively removed these oxyanions by precipitation as insoluble Ce2(SeO3)3(s), Ce2(CO3)3(s), CePO4(s), and CeAsO4(s), respectively.	Selenic Acid	10-18	carboxylesterase 2	Homo sapiens	195-198
32138548-4	2020	Dissolved selenate was separated from dissolved selenite, carbonate, phosphate, and arsenate by addition of Ce3+ cations that quantitatively removed these oxyanions by precipitation as insoluble Ce2(SeO3)3(s), Ce2(CO3)3(s), CePO4(s), and CeAsO4(s), respectively.	Selenic Acid	10-18	carboxylesterase 2	Homo sapiens	210-213
31822702-9	2019	We also found selenate treatment significantly down-regulated activity of the Akt pathway, which was activated in response to lipid-overload.	Selenic Acid	14-22	thymoma viral proto-oncogene 1	Mus musculus	78-81
31822702-11	2019	Taken together, selenate offers therapeutic intervention in lipid-related metabolic disorders, and protection against cardiac remodeling, likely through regulation of the activity of autophagic degradation and Akt pathway.	Selenic Acid	16-24	thymoma viral proto-oncogene 1	Mus musculus	210-213
30790121-4	2019	It was found that the administration of selenate reversed the alterations of the differentially expressed serum proteins by up-regulating 13 proteins and down-regulating 2 proteins which were reported to be involved in the key pathogenesis of AD, including regulation of Abeta production, lipid metabolism regulation, and anti-inflammation.	Selenic Acid	40-48	histocompatibility 2, class II antigen A, beta 1	Mus musculus	271-276
30790121-5	2019	These results suggested that a dietary supplement with selenate is effective for prevention and treatment of AD, and the mechanism was maybe related to its role in Abeta regulation, lipid metabolism, and anti-inflammation.	Selenic Acid	55-63	histocompatibility 2, class II antigen A, beta 1	Mus musculus	164-169
30790121-6	2019	Moreover, we also presented that alpha-2 macroglobulin, transthyretin, haptoglobin, alpha-2-HS-glycoprotein, and alpha-1-antitrypsin in the serum can be used to evaluate the effect of selenate on AD pathology.	Selenic Acid	184-192	alpha-2-macroglobulin	Mus musculus	33-54
31109102-7	2019	Selenate and tunicamycin (Tm) treatment were used to induce SELENOF up-regulation.	Selenic Acid	0-8	selenoprotein F	Homo sapiens	60-67
31088374-11	2019	MeJA and BR treatments, conferred the biosynthesis of glucosinolates, and Se and MeJA contributed to sulforaphane in Chinese kale via regulating the expression of CYP83b1, SUR1 and UGT74b1.	Selenic Acid	74-76	ATP binding cassette subfamily C member 8	Homo sapiens	172-176
27045899-6	2018	hrd1a/hrd1b and sel1l mutants treated with selenate demonstrate decreased tolerance and ER stress, as judged by BiP2 accumulation.	Selenic Acid	43-51	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase	Homo sapiens	16-21
28711506-0	2017	Sodium selenate activated Wnt/beta-catenin signaling and repressed amyloid-beta formation in a triple transgenic mouse model of Alzheimer"s disease.	Selenic Acid	0-15	catenin (cadherin associated protein), beta 1	Mus musculus	30-42
29574326-5	2018	In this work, we studied the promoter activity of the Arabidopsis SBP genes, determined their tissue specificity and showed that they are differentially regulated by sodium selenite and sodium selenate.	Selenic Acid	186-201	selenium binding protein	Arabidopsis thaliana	66-69
29116766-2	2017	Smaller [H2SeO4]/[Th(IV)] ratio or lower temperature give rise to the formation of octameric [Th8(mu3-O)4(mu2-OH)8]16+ cores in Th-1/Th-2 and infinite [Th(mu2-OH)2H2O]2+ chains in Th-3, respectively.	Selenic Acid	9-15	negative elongation factor complex member C/D	Homo sapiens	128-132
28711506-2	2017	Sodium selenate has been reported to reduce neurofibrillary tangles (NFT) in the tauopathic mouse models, but its effects on the Wnt/beta-catenin signaling pathway and APP processing remain unknown during AD formation.	Selenic Acid	0-15	catenin (cadherin associated protein), beta 1	Mus musculus	133-145
28711506-6	2017	Treatment with sodium selenate significantly promoted the activity of protein phosphatases of type 2A (PP2A) and repressed the hallmarks of AD.	Selenic Acid	15-30	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	103-107
28711506-7	2017	Activation of PP2A by sodium selenate could increase active beta-catenin level and inhibit GSK3beta activity in the hippocampal tissue and primarily cultured neurons of AD model mouse, leading to activation of Wnt/beta-catenin signaling and transactivation of target genes, including positively-regulated genes c-myc, survivin, TXNRD2 and negatively-regulated gene BACE1.	Selenic Acid	22-37	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	14-18
28711506-7	2017	Activation of PP2A by sodium selenate could increase active beta-catenin level and inhibit GSK3beta activity in the hippocampal tissue and primarily cultured neurons of AD model mouse, leading to activation of Wnt/beta-catenin signaling and transactivation of target genes, including positively-regulated genes c-myc, survivin, TXNRD2 and negatively-regulated gene BACE1.	Selenic Acid	22-37	catenin (cadherin associated protein), beta 1	Mus musculus	60-72
28711506-7	2017	Activation of PP2A by sodium selenate could increase active beta-catenin level and inhibit GSK3beta activity in the hippocampal tissue and primarily cultured neurons of AD model mouse, leading to activation of Wnt/beta-catenin signaling and transactivation of target genes, including positively-regulated genes c-myc, survivin, TXNRD2 and negatively-regulated gene BACE1.	Selenic Acid	22-37	glycogen synthase kinase 3 alpha	Mus musculus	91-99
28711506-7	2017	Activation of PP2A by sodium selenate could increase active beta-catenin level and inhibit GSK3beta activity in the hippocampal tissue and primarily cultured neurons of AD model mouse, leading to activation of Wnt/beta-catenin signaling and transactivation of target genes, including positively-regulated genes c-myc, survivin, TXNRD2 and negatively-regulated gene BACE1.	Selenic Acid	22-37	catenin (cadherin associated protein), beta 1	Mus musculus	214-226
28711506-7	2017	Activation of PP2A by sodium selenate could increase active beta-catenin level and inhibit GSK3beta activity in the hippocampal tissue and primarily cultured neurons of AD model mouse, leading to activation of Wnt/beta-catenin signaling and transactivation of target genes, including positively-regulated genes c-myc, survivin, TXNRD2 and negatively-regulated gene BACE1.	Selenic Acid	22-37	baculoviral IAP repeat-containing 5	Mus musculus	318-326
28711506-7	2017	Activation of PP2A by sodium selenate could increase active beta-catenin level and inhibit GSK3beta activity in the hippocampal tissue and primarily cultured neurons of AD model mouse, leading to activation of Wnt/beta-catenin signaling and transactivation of target genes, including positively-regulated genes c-myc, survivin, TXNRD2 and negatively-regulated gene BACE1.	Selenic Acid	22-37	thioredoxin reductase 2	Mus musculus	328-334
28711506-7	2017	Activation of PP2A by sodium selenate could increase active beta-catenin level and inhibit GSK3beta activity in the hippocampal tissue and primarily cultured neurons of AD model mouse, leading to activation of Wnt/beta-catenin signaling and transactivation of target genes, including positively-regulated genes c-myc, survivin, TXNRD2 and negatively-regulated gene BACE1.	Selenic Acid	22-37	beta-site APP cleaving enzyme 1	Mus musculus	365-370
28711506-9	2017	These findings reveal that the Wnt/beta-catenin signaling is a potential target for prevention of AD and sodium selenate may be developed as a new drug for AD treatment.	Selenic Acid	105-120	catenin (cadherin associated protein), beta 1	Mus musculus	35-47
28131038-1	2017	Microbial reduction of selenium sulfide (SeS2) is a key step in a new treatment process to recover selenium from selenate and selenite streams.	Selenic Acid	113-121	secernin 2	Homo sapiens	41-45
28131038-2	2017	In this process, selenate is first reduced to selenite, and subsequently selenite is reduced by sulfide and precipitates from the solution as SeS2.	Selenic Acid	17-25	secernin 2	Homo sapiens	142-146
28478440-5	2017	RESULTS: In a patient with the tubulin-related TUBA4A mutation, we found highly elevated levels (in mug/L) of glutathione-peroxidase-bound selenium (32.8 vs. 1.0) as well as increased levels of selenoprotein-P-bound selenium (2.4 vs. 0.8), selenite (1.8 vs. 0.1), and selenate (0.9 vs. 0.1).	Selenic Acid	268-276	tubulin alpha 4a	Homo sapiens	47-53
28098937-5	2017	In this study, we investigated whether sodium selenate treatment improved the neurologic alterations and the hyperexcitability present in the Epm2b-/- mouse model.	Selenic Acid	39-54	NHL repeat containing 1	Mus musculus	142-147
28098937-6	2017	RESULTS: Sodium selenate ameliorates some of the motor and memory deficits and the sensitivity observed with pentylenetetrazol (PTZ) treatments in Epm2b-/- mice.	Selenic Acid	9-24	NHL repeat containing 1	Mus musculus	147-152
27802219-5	2017	We therefore proposed that increased SelS expression by selenate would contribute to the beneficial actions of selenate in Alzheimer"s disease.	Selenic Acid	56-64	selenoprotein S	Homo sapiens	37-41
27802219-5	2017	We therefore proposed that increased SelS expression by selenate would contribute to the beneficial actions of selenate in Alzheimer"s disease.	Selenic Acid	111-119	selenoprotein S	Homo sapiens	37-41
27802219-8	2017	Selenate increased SelS expression, which significantly correlated with decreased tau phosphorylation.	Selenic Acid	0-8	selenoprotein S	Homo sapiens	19-23
27802219-11	2017	These results indicate that selenate can alter phosphorylation of tau by increasing expression of SelS in Alzheimer"s disease and potentially other neurodegenerative disorders.	Selenic Acid	28-36	selenoprotein S	Homo sapiens	98-102
28008954-7	2016	Finally, we measured the activities of two important anti-oxidative selenoenzymes, glutathione peroxidase and thioredoxin reductase, and found that they were remarkably increased in the cerebrum of selenate-treated mice, suggesting that selenoenzyme-mediated protection against oxidative stress might also be involved in the therapeutic effect of selenate in AD.	Selenic Acid	198-206	peroxiredoxin 2	Mus musculus	110-131
26894577-8	2016	Conversely, pharmacological activation of PP2A by sodium selenate showed a partial neuroprotection from R1441C-LRRK2-induced cellular degeneration.	Selenic Acid	50-65	protein phosphatase 2 phosphatase activator	Homo sapiens	42-46
27530256-7	2016	Selenate is a potent inhibitor of tau hyperphosphorylation, a critical step in the formation of neurofibrillary tangles.	Selenic Acid	0-8	microtubule associated protein tau	Homo sapiens	34-37
27447428-2	2016	Sodium selenate directly stimulates the activity of PP2A, the main enzyme responsible for h-tau dephosphorylation in the brain.	Selenic Acid	0-15	protein phosphatase 2 phosphatase activator	Homo sapiens	52-56
26894577-8	2016	Conversely, pharmacological activation of PP2A by sodium selenate showed a partial neuroprotection from R1441C-LRRK2-induced cellular degeneration.	Selenic Acid	50-65	leucine rich repeat kinase 2	Homo sapiens	111-116
26146537-7	2015	This sensor set was able to identify two unknown anion samples from ten closely-responding anions and could also function quantitatively, determining unknown concentrations of anions such as cyanide (as low as 1 mM) and selenate (as low as 50 muM).	Selenic Acid	220-228	latexin	Homo sapiens	243-246
26938500-2	2016	When only selenate (50 muM) was fed to the UASB reactors (pH 7.3; hydraulic retention time 8 h) with excess electron donor (lactate at 1.38 mM corresponding to an organic loading rate of 0.5 g COD L(-1) d(-1)), the thermophilic UASB reactor achieved a higher total Se removal efficiency (94.4 +- 2.4%) than the mesophilic UASB reactor (82.0 +- 3.8%).	Selenic Acid	10-18	latexin	Homo sapiens	23-26
25771151-0	2015	Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury.	Selenic Acid	0-15	microtubule associated protein tau	Homo sapiens	44-47
25771151-4	2015	Here we investigated whether traumatic brain injury in rats and humans would induce changes in protein phosphatase 2A and phosphorylated tau, and whether treatment with sodium selenate-a potent PR55 activator-would reduce phosphorylated tau and improve traumatic brain injury outcomes in rats.	Selenic Acid	169-184	microtubule associated protein tau	Homo sapiens	137-140
25771151-4	2015	Here we investigated whether traumatic brain injury in rats and humans would induce changes in protein phosphatase 2A and phosphorylated tau, and whether treatment with sodium selenate-a potent PR55 activator-would reduce phosphorylated tau and improve traumatic brain injury outcomes in rats.	Selenic Acid	169-184	microtubule associated protein tau	Homo sapiens	237-240
25771151-12	2015	Continuous sodium selenate treatment for 12 weeks after sham or fluid percussion injury in rats increased protein phosphatase 2A activity and PR55 expression, and reduced the ratio of phosphorylated tau to total tau, attenuated brain damage, and improved behavioural outcomes in rats given a fluid percussion injury.	Selenic Acid	11-26	microtubule associated protein tau	Homo sapiens	199-202
25771151-12	2015	Continuous sodium selenate treatment for 12 weeks after sham or fluid percussion injury in rats increased protein phosphatase 2A activity and PR55 expression, and reduced the ratio of phosphorylated tau to total tau, attenuated brain damage, and improved behavioural outcomes in rats given a fluid percussion injury.	Selenic Acid	11-26	microtubule associated protein tau	Homo sapiens	212-215
25771151-13	2015	Notably, total tau levels were decreased in rats 12 weeks after fluid percussion injury, and several other factors, including the use of anaesthetic, the length of recovery time, and that some brain injury and behavioural dysfunction still occurred in rats treated with sodium selenate must be considered in the interpretation of this study.	Selenic Acid	270-285	microtubule associated protein tau	Homo sapiens	15-18
25771151-14	2015	However, taken together these data suggest protein phosphatase 2A and hyperphosphorylated tau may be involved in the neurodegenerative cascade of traumatic brain injury, and support the potential use of sodium selenate as a novel traumatic brain injury therapy.	Selenic Acid	203-218	microtubule associated protein tau	Homo sapiens	90-93
23769801-0	2013	Selenate induces epithelial-mesenchymal transition in a colorectal carcinoma cell line by AKT activation.	Selenic Acid	0-8	AKT serine/threonine kinase 1	Homo sapiens	90-93
25245030-6	2014	APR2 is a key enzyme in both sulfate and selenate reduction, and its reduced activity in the loss-of-function allele apr2-1 and the two Arabidopsis accessions Hodonin and Shahdara leads to a lowering of sulfur flux from sulfate into the reduced sulfur compounds, cysteine and glutathione, and into proteins, concomitant with an increase in the accumulation of sulfate in leaves.	Selenic Acid	41-49	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	0-4
25245030-6	2014	APR2 is a key enzyme in both sulfate and selenate reduction, and its reduced activity in the loss-of-function allele apr2-1 and the two Arabidopsis accessions Hodonin and Shahdara leads to a lowering of sulfur flux from sulfate into the reduced sulfur compounds, cysteine and glutathione, and into proteins, concomitant with an increase in the accumulation of sulfate in leaves.	Selenic Acid	41-49	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	117-121
23769801-2	2013	Selenate acts by activating protein phosphatase 2A, which inhibits various signal transduction cascades, including the phosphatidylinositol 3-kinase (PI3K)/AKT pathway.	Selenic Acid	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	119-148
23769801-2	2013	Selenate acts by activating protein phosphatase 2A, which inhibits various signal transduction cascades, including the phosphatidylinositol 3-kinase (PI3K)/AKT pathway.	Selenic Acid	0-8	AKT serine/threonine kinase 1	Homo sapiens	156-159
23769801-7	2013	Moreover, selenate-induced EMT was associated with AKT activation, increased expression of the EMT-inducing transcription factor TWIST1 and the mesenchymal cell-specific intermediate filament vimentin, and decreased expression of the epithelial cell-specific adhesion molecule E-cadherin.	Selenic Acid	10-18	AKT serine/threonine kinase 1	Homo sapiens	51-54
23769801-7	2013	Moreover, selenate-induced EMT was associated with AKT activation, increased expression of the EMT-inducing transcription factor TWIST1 and the mesenchymal cell-specific intermediate filament vimentin, and decreased expression of the epithelial cell-specific adhesion molecule E-cadherin.	Selenic Acid	10-18	twist family bHLH transcription factor 1	Homo sapiens	129-135
23769801-7	2013	Moreover, selenate-induced EMT was associated with AKT activation, increased expression of the EMT-inducing transcription factor TWIST1 and the mesenchymal cell-specific intermediate filament vimentin, and decreased expression of the epithelial cell-specific adhesion molecule E-cadherin.	Selenic Acid	10-18	cadherin 1	Homo sapiens	277-287
23769801-8	2013	The critical role of AKT activation in selenate-induced EMT was identified using the AKT inhibitor Akti-1/2, which suppressed EMT-associated cell motility and invasion.	Selenic Acid	39-47	AKT serine/threonine kinase 1	Homo sapiens	21-24
23769801-8	2013	The critical role of AKT activation in selenate-induced EMT was identified using the AKT inhibitor Akti-1/2, which suppressed EMT-associated cell motility and invasion.	Selenic Acid	39-47	AKT serine/threonine kinase 1	Homo sapiens	85-88
23506872-3	2013	While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate.	Selenic Acid	100-108	solute carrier family 13 member 1	Homo sapiens	35-39
23506872-3	2013	While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate.	Selenic Acid	100-108	solute carrier family 13 member 1	Homo sapiens	41-48
23506872-3	2013	While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate.	Selenic Acid	100-108	solute carrier family 13 member 4	Homo sapiens	54-58
23506872-3	2013	While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate.	Selenic Acid	100-108	solute carrier family 13 member 4	Homo sapiens	60-67