PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2421157-0	1986	The rad2 mutation affects the molecular nature of UV and acridine-mustard-induced mutations in the ADE2 gene of Saccharomyces cerevisiae.	Acridines	57-65	ssDNA endodeoxyribonuclease RAD2	Saccharomyces cerevisiae S288C	4-8
2421157-0	1986	The rad2 mutation affects the molecular nature of UV and acridine-mustard-induced mutations in the ADE2 gene of Saccharomyces cerevisiae.	Acridines	57-65	phosphoribosylaminoimidazole carboxylase ADE2	Saccharomyces cerevisiae S288C	99-103
2421157-1	1986	We have studied the molecular nature of ade2 mutations induced by UV light and bifunctional acridine-mustard (BAM) in wild-type (RAD) and in excision-deficient (rad2) strains of the yeast, Saccharomyces cerevisiae.	Acridines	92-100	phosphoribosylaminoimidazole carboxylase ADE2	Saccharomyces cerevisiae S288C	40-44
6689124-1	1983	An acridine antitumor agent, 4"-(9-acridinylamino)methanesulfon-m-anisidide, has been found to be an extremely potent competitive inhibitor of aldehyde oxidase (EC 1.2.3.1).	Acridines	3-11	aldehyde oxidase 1	Homo sapiens	143-159
6349762-1	1983	Mutants at the ade4 locus of yeast were isolated following mutagenesis of ade+ and ade2 with ultraviolet light (UV), ethylmethane sulphonate, and the acridine half mustard ICR-170.	Acridines	150-158	amidophosphoribosyltransferase	Saccharomyces cerevisiae S288C	15-19
520311-1	1979	The interactions of three groups of probes (berberine alkaloids, tricyclic psychopharmaca and acridine derivatives) with isoenzymes of horse liver alcohol dehydrogenase and with rat liver alcohol dehydrogenase have been examined.	Acridines	94-102	aldo-keto reductase family 1 member A1	Rattus norvegicus	147-168
7057055-4	1982	Among several defined constituents of coal tar tested benzo(a)pyrene (BP), anthracene and acridine were found to have measurable induction effects on neonatal rat skin and liver AHH.	Acridines	90-98	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	178-181
114334-0	1979	[Inhibition of the fluorescence of acridine, 9-aminoacridine, and 9-amino-6-chloroacridine by human serum albumin].	Acridines	35-43	albumin	Homo sapiens	106-113
114334-1	1979	Study of fluorescence quenching of acridine and some 9 amino acridines upon human serum albumin additions reveals a single protein fixation site.	Acridines	35-43	albumin	Homo sapiens	82-95
33749516-5	2021	After extensive screening, we found that acridine derivative 2c and acridine dimer DI26 could selectively interact with TRF1 and telomeric i-motif, respectively.	Acridines	41-49	telomeric repeat binding factor 1	Mus musculus	120-124
25133-0	1978	Induction of limited DNA damage by the antitumor agent Cain"s acridine.	Acridines	62-70	calcineurin binding protein 1	Homo sapiens	55-59
4402537-7	1972	The acridine system has the attractive property that the enzyme, ferredoxin-NADP reductase, is the only component of the system that absorbs appreciably in the visible region of the spectrum.	Acridines	4-12	ferredoxin reductase	Homo sapiens	65-90
1200845-0	1975	Comparison of the ability of small molecular interferon inducers: tilorone and acridine drugs.	Acridines	79-87	interferon	Gallus gallus	45-55
33749516-5	2021	After extensive screening, we found that acridine derivative 2c and acridine dimer DI26 could selectively interact with TRF1 and telomeric i-motif, respectively.	Acridines	68-76	telomeric repeat binding factor 1	Mus musculus	120-124
31717694-7	2019	Acridine orange and monodansylcadaverine staining, immunocytochemistry, and immunoblotting analyses revealed the induction of autophagy in renal cancer cells following PKM2 knockdown.	Acridines	0-8	pyruvate kinase M1/2	Homo sapiens	168-172
33339082-0	2020	Design, synthesis and biological assessment of acridine derivatives containing 1,3,4-thiadiazole moiety as novel selective acetylcholinesterase inhibitors.	Acridines	47-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-143
31917988-4	2020	Recently, we have identified an acridine derivative, AIM4, as an anti-TDP-43 aggregation molecule however, its mechanism is not deciphered.	Acridines	32-40	TAR DNA binding protein	Homo sapiens	70-76
32073280-1	2020	Herein, we reported Lewis acid- or Bronsted acid-promoted intramolecular C(sp2)-C(sp2) bond cleavage and a novel C(sp2)-C(sp2) bond-forming cascade reaction to synthesize the acridine motif.	Acridines	175-183	Sp2 transcription factor	Homo sapiens	73-78
32073280-1	2020	Herein, we reported Lewis acid- or Bronsted acid-promoted intramolecular C(sp2)-C(sp2) bond cleavage and a novel C(sp2)-C(sp2) bond-forming cascade reaction to synthesize the acridine motif.	Acridines	175-183	Sp2 transcription factor	Homo sapiens	80-85
32073280-1	2020	Herein, we reported Lewis acid- or Bronsted acid-promoted intramolecular C(sp2)-C(sp2) bond cleavage and a novel C(sp2)-C(sp2) bond-forming cascade reaction to synthesize the acridine motif.	Acridines	175-183	Sp2 transcription factor	Homo sapiens	80-85
32073280-1	2020	Herein, we reported Lewis acid- or Bronsted acid-promoted intramolecular C(sp2)-C(sp2) bond cleavage and a novel C(sp2)-C(sp2) bond-forming cascade reaction to synthesize the acridine motif.	Acridines	175-183	Sp2 transcription factor	Homo sapiens	80-85
31659628-8	2020	The formation of autolysosomes in response to CCN1 (5 mug/ml; 3 h) treatment was identified by the acridine orange staining.	Acridines	99-107	cellular communication network factor 1	Mus musculus	46-50
31974874-0	2020	A Facile Preparation of a New Water-Soluble Acridine Derivative and Application as a Turn-off Fluorescence Chemosensor for Selective Detection of Hg2.	Acridines	44-52	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	146-149
31974874-1	2020	A new acridine-based chemosensor was prepared, characterized and investigated for quantitative detection of Hg2+ ions in aqueous solutions.	Acridines	6-14	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	108-111
30526469-3	2020	Formerly, acridines, N4-sulfonamido-succinamic, phthalamic, acrylic and benzoyl acetic acid derivatives, and sulfamoyl-phenyl acid esters were designed and developed as new DPP-IV inhibitors.	Acridines	10-19	dipeptidyl peptidase 4	Homo sapiens	173-179
32568540-0	2020	Tert-butyl bromide promoted intramolecular cyclization of 2-arylamino phenyl ketones and its combination with Cu-catalyzed C-N coupling: synthesis of acridines at room temperature.	Acridines	150-159	telomerase reverse transcriptase	Homo sapiens	0-4
32151835-2	2020	In this study, the HDAC inhibitor core is incorporated into the acetylcholine esterase (ACE) inhibitor acridine-derived moiety and resulted in compounds that exhibited higher class IIa HDAC (4, 5, 7, and 9)- and class IIb HDAC6-inhibiting activity when compared to the pan-HDAC inhibitor SAHA in clinical practice.	Acridines	103-111	angiotensin I converting enzyme	Homo sapiens	64-86
32151835-2	2020	In this study, the HDAC inhibitor core is incorporated into the acetylcholine esterase (ACE) inhibitor acridine-derived moiety and resulted in compounds that exhibited higher class IIa HDAC (4, 5, 7, and 9)- and class IIb HDAC6-inhibiting activity when compared to the pan-HDAC inhibitor SAHA in clinical practice.	Acridines	103-111	angiotensin I converting enzyme	Homo sapiens	88-91
32236264-1	2020	In this work, the origin of the singlet and triplet exciton-induced degradation of host materials with C(sp2)-N(sp3) bonds around nitrogen (carbazoles, acridines, etc.	Acridines	152-161	Sp2 transcription factor	Homo sapiens	103-108
31834986-5	2020	Acridine orange was found to be a MAO-A specific inhibitor (IC50 = 0.017 muM), whereas oxazine 170 is a MAO-B specific inhibitor (IC50 = 0.0065 muM).	Acridines	0-8	monoamine oxidase A	Homo sapiens	34-39
31834986-5	2020	Acridine orange was found to be a MAO-A specific inhibitor (IC50 = 0.017 muM), whereas oxazine 170 is a MAO-B specific inhibitor (IC50 = 0.0065 muM).	Acridines	0-8	latexin	Homo sapiens	73-76
31807868-7	2020	Apoptosis induced in the parasite as a consequence of probable inhibition of thymidylate synthase was studied by acridine orange/ethidium bromide fluorescent staining and poly (ADP-ribose) polymerase activity inhibition.	Acridines	113-121	thymidylate synthetase	Homo sapiens	77-97
31558764-2	2019	The photocatalytic performance of the Nd1-xSrxMnO3 nanocomposites for photodegradation of Acridine orange dye (AO) was evaluated over visible light illumination.	Acridines	90-98	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	38-41
30689223-2	2019	In the presence of mono-alcohols, DAB 1 forms borate 2 by boronic ester formation, followed by coordination of the acridine moiety to the boron atom.	Acridines	115-123	DAB adaptor protein 1	Homo sapiens	34-39
30204186-2	2018	We report here the synthesis of seven new cyclometalated Au(iii) complexes with five of them bearing an acridine moiety attached via (N^O) or (N^N) chelates, acyclic amino carbenes (AAC) and N-heterocyclic carbenes (NHC).	Acridines	104-112	glycine-N-acyltransferase	Homo sapiens	182-185
30401647-4	2019	Spectroscopic results reveals that the acridine derivatives interact strongly (Ka   104 - 105 M-1) with the mushroom tyrosinase and the enzyme undergoes small structural modifications due to the interaction with AMTAC-01 compound.	Acridines	39-47	tyrosinase	Homo sapiens	117-127
30863699-3	2019	Flow-cytometry analysis shows Asc-s treatment-induced accumulation of cells at sub-G0/G1 stage of cell cycle and induced apoptosis as confirmed by DAPI, propodium iodide, and acridine staining in HeLa cells.	Acridines	175-183	PYD and CARD domain containing	Homo sapiens	30-33
30059876-11	2018	Long hydrophobic tail containing acridine conjugate (AC-PA) shows more efficient binding interactions with the beta-CD and the calculated binding constants value of AC-PA is 0.51 x 102M-1.	Acridines	33-41	proteinase 3	Homo sapiens	53-58
30059876-11	2018	Long hydrophobic tail containing acridine conjugate (AC-PA) shows more efficient binding interactions with the beta-CD and the calculated binding constants value of AC-PA is 0.51 x 102M-1.	Acridines	33-41	proteinase 3	Homo sapiens	165-170
29980114-1	2018	A novel series of acridine linked to thioacetamides 9a-o were synthesized and evaluated for their alpha-glucosidase inhibitory and cytotoxic activities.	Acridines	18-26	sucrase-isomaltase	Homo sapiens	98-115
30107347-0	2018	Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7.	Acridines	45-53	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	85-123
32002956-0	2018	Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7.	Acridines	45-53	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	85-123
28834568-8	2018	Several PACs, such as acridine and its derivatives, appear to directly activate the ER.	Acridines	22-30	estrogen receptor 1	Homo sapiens	84-86
29635185-1	2018	Two novel acridine-based fluorescence chemosensors (L1 and L2) were prepared and their metal ions sensing properties were investigated.	Acridines	10-18	L1 cell adhesion molecule	Homo sapiens	52-61
30429967-1	2018	"Acridine" along with its functional analogue "Acridone" is the most privileged pharmacophore in medicinal chemistry with diverse applications ranging from DNA intercalators, endonuclease mimics, ratiometric selective ion sensors, and P-glycoprotein inhibitors in countering the multi-drug resistance, enzyme inhibitors, and reversals of neurodegenerative disorders.	Acridines	1-9	ATP binding cassette subfamily B member 1	Homo sapiens	235-249
30109109-5	2018	Moreover, during the synthesis of acridine probes 3a-c nickel fluoride (NiF2), a rarely explored transition metal fluoride salt, was used as the catalyst.	Acridines	34-42	zinc finger protein 335	Homo sapiens	72-76
29487133-5	2018	We found that the most potent BLVRB inhibitors contain a tricyclic hydrocarbon core structure similar to the isoalloxazine ring of flavin mononucleotide and that both xanthene- and acridine-based compounds inhibit BLVRB"s flavin and dichlorophenolindophenol (DCPIP) reductase functions.	Acridines	181-189	biliverdin reductase B	Homo sapiens	30-35
29487133-5	2018	We found that the most potent BLVRB inhibitors contain a tricyclic hydrocarbon core structure similar to the isoalloxazine ring of flavin mononucleotide and that both xanthene- and acridine-based compounds inhibit BLVRB"s flavin and dichlorophenolindophenol (DCPIP) reductase functions.	Acridines	181-189	biliverdin reductase B	Homo sapiens	214-219
29487133-8	2018	Both acridine- and xanthene-based compounds caused selective and concentration-dependent loss of redox coupling in BLVRB-overexpressing promyelocytic HL-60 cells.	Acridines	5-13	biliverdin reductase B	Homo sapiens	115-120
28986116-1	2017	We investigated the inhibitory activity of 4 groups of novel acridine derivatives against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and carboxylesterase (CaE) using the methods of enzyme kinetics and molecular docking.	Acridines	61-69	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-110
28986116-1	2017	We investigated the inhibitory activity of 4 groups of novel acridine derivatives against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and carboxylesterase (CaE) using the methods of enzyme kinetics and molecular docking.	Acridines	61-69	butyrylcholinesterase	Homo sapiens	119-140
28986116-1	2017	We investigated the inhibitory activity of 4 groups of novel acridine derivatives against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and carboxylesterase (CaE) using the methods of enzyme kinetics and molecular docking.	Acridines	61-69	butyrylcholinesterase	Homo sapiens	142-146
28986116-3	2017	Analysis of the esterase profiles and antiradical activities of the acridine derivatives showed that 9-aryl(heteroaryl)-N-methyl-9,10-dihydroacridines have a high radical-scavenging activity but low potency as AChE and BChE inhibitors, whereas 9-aryl(heteroaryl)-N-methyl-acridinium tetrafluoroborates effectively inhibit cholinesterases but do not exhibit antiradical activity.	Acridines	68-76	butyrylcholinesterase	Homo sapiens	219-223
28986116-5	2017	The results of molecular docking well explain the observed features in the efficacy, selectivity, and mechanism of cholinesterase inhibition by the acridine derivatives.	Acridines	148-156	butyrylcholinesterase	Homo sapiens	115-129
28986116-6	2017	Thus, in a series of acridine derivatives we have found compounds possessing dual properties of effective and selective cholinesterase inhibition together with free radical scavenging, which makes promising the use of the acridine scaffold to create multifunctional drugs for the therapy of neurodegenerative diseases.	Acridines	21-29	butyrylcholinesterase	Homo sapiens	120-134
28986116-6	2017	Thus, in a series of acridine derivatives we have found compounds possessing dual properties of effective and selective cholinesterase inhibition together with free radical scavenging, which makes promising the use of the acridine scaffold to create multifunctional drugs for the therapy of neurodegenerative diseases.	Acridines	222-230	butyrylcholinesterase	Homo sapiens	120-134
28881653-7	2017	Furthermore, induction of autophagy was also demonstrated in PC-3 and PC-3a cells treated with some acridine compounds by LC3 conversion immunoblotting and LC3 fluorescence microscopy.	Acridines	100-108	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	122-125
28645477-0	2017	The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748.	Acridines	157-165	cytochrome p450 oxidoreductase	Homo sapiens	22-25
28512780-1	2017	Novel chiral fluorescence sensors L-1 and D-1 incorporating N-Boc-protected alanine and acridine moieties were synthesized.	Acridines	88-96	L1 cell adhesion molecule	Homo sapiens	34-65
28881653-7	2017	Furthermore, induction of autophagy was also demonstrated in PC-3 and PC-3a cells treated with some acridine compounds by LC3 conversion immunoblotting and LC3 fluorescence microscopy.	Acridines	100-108	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	156-159
26687098-1	2016	Novel acridine-based fluorescence sensors containing alaninol ligands, L1 and D1, were designed and synthesized.	Acridines	6-14	immunoglobulin kappa variable 1-16	Homo sapiens	71-80
28000730-6	2016	Among several acridine derivatives examined, AIM4, which contains polar carboxyl groups in the side arms, significantly reduces TDP-43-YFP aggregation in the powerful yeast model cell and also abolishes in vitro amyloid-like aggregation of carboxyl terminal domain of TDP-43, as observed by AFM imaging.	Acridines	14-22	Aim4p	Saccharomyces cerevisiae S288C	45-49
28013041-3	2017	Acridine-orange labeling of the CA3 field reveals an enhancing green fluorescence of glyocites in stress conditions.	Acridines	0-8	carbonic anhydrase 3	Rattus norvegicus	32-35
28413956-4	2017	CONCLUSION: The chemical space of Haspin-targeting low-molecular-weight-compounds has not yet been widely explored, but several scaffolds (e.g., derivatives of acridine, beta-carboline or 5-iodotubercidin) have emerged as promising inhibitors.	Acridines	160-168	histone H3 associated protein kinase	Homo sapiens	34-40
27307600-0	2016	Acridine Derivatives as Inhibitors of the IRE1alpha-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.	Acridines	0-8	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	42-51
27307600-0	2016	Acridine Derivatives as Inhibitors of the IRE1alpha-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.	Acridines	0-8	X-box binding protein 1	Homo sapiens	52-56
26156660-1	2015	The synthesis and biological evaluation of a series of bifunctional acridine-HSP90 inhibitor ligands as telomerase inhibitors is herein described.	Acridines	68-76	heat shock protein 90 alpha family class A member 1	Homo sapiens	77-82
26707846-0	2016	Design, synthesis and evaluation of acridine derivatives as multi-target Src and MEK kinase inhibitors for anti-tumor treatment.	Acridines	36-44	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	73-76
26707846-0	2016	Design, synthesis and evaluation of acridine derivatives as multi-target Src and MEK kinase inhibitors for anti-tumor treatment.	Acridines	36-44	mitogen-activated protein kinase kinase 7	Homo sapiens	81-84
26707846-8	2016	Our study suggested that acridine scaffold, particularly compound 8m, is of potential interest for developing novel multi-target Src and MEK kinase inhibitors.	Acridines	25-33	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	129-132
26707846-8	2016	Our study suggested that acridine scaffold, particularly compound 8m, is of potential interest for developing novel multi-target Src and MEK kinase inhibitors.	Acridines	25-33	mitogen-activated protein kinase kinase 7	Homo sapiens	137-140
26156660-2	2015	Four hybrid acridine-HSP90 inhibitor conjugates were prepared using a click-chemistry approach, and subsequently shown to display comparable results to the established telomerase inhibitor BRACO-19 in the TRAP-LIG telomerase assay.	Acridines	12-20	heat shock protein 90 alpha family class A member 1	Homo sapiens	21-26
23688499-0	2013	Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia.	Acridines	93-101	nuclear receptor subfamily 1 group I member 2	Homo sapiens	0-19
25194318-0	2015	A simple-structured acridine derivative as a fluorescent enhancement chemosensor for the detection of Pd2+ in aqueous media.	Acridines	20-28	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	102-105
24989818-2	2014	Due to the strong fluorescence of the acridine yellow fluorophore, it is not completely quenched when the ligand is coordinated to Co(II) .	Acridines	38-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
25344835-5	2014	We have identified an acridine derivative (PubChem CID-765471) previously known for its capacity to activate p53 independently of DNA damage, although the molecular mechanism underlying p53 activation had remained uncharacterized.	Acridines	22-30	tumor protein p53	Homo sapiens	109-112
25344835-5	2014	We have identified an acridine derivative (PubChem CID-765471) previously known for its capacity to activate p53 independently of DNA damage, although the molecular mechanism underlying p53 activation had remained uncharacterized.	Acridines	22-30	tumor protein p53	Homo sapiens	186-189
24890801-2	2014	We have elucidated the influence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector.	Acridines	104-112	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	36-42
23688499-0	2013	Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia.	Acridines	93-101	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	47-53
23688499-0	2013	Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia.	Acridines	93-101	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	58-64
23516967-8	2013	The trilayer is stabilized by the strong self-aggregation acridine dye group of the DAO molecule.	Acridines	58-66	D-amino acid oxidase	Homo sapiens	84-87
22335895-3	2012	Based on information obtained from a structure-activity relationship study previously conducted for an acridine series of haspin inhibitors in conjunction with in silico docking using a recently disclosed crystal structure of the kinase, harmine analogs were designed that resulted in significantly increased haspin kinase inhibitory potency.	Acridines	103-111	histone H3 associated protein kinase	Mus musculus	122-128
23344363-1	2013	The aim of the present study was to characterize the binding property of quinacrine-based acridine derivatives for Abeta plaques and to evaluate this series of compounds as Abeta imaging probes.	Acridines	90-98	histocompatibility 2, class II antigen A, beta 1	Mus musculus	115-120
23344363-8	2013	It should be noted that the acridines showed much higher binding affinity for Abeta aggregates and greater in vivo blood brain barrier permeability than [(125)I]5.	Acridines	28-37	histocompatibility 2, class II antigen A, beta 1	Mus musculus	78-83
23593653-12	2013	These gene desilencing agents belonged to a class of acridine compounds, intercalated into DNA, and inhibited DNMT1 activity in vitro.	Acridines	53-61	DNA methyltransferase 1	Homo sapiens	110-115
23200222-6	2013	The complex was also found to significantly increase the level of caspase-3 in laboratory animals compared to the acridine ligand and to the control group.	Acridines	114-122	caspase 3	Mus musculus	66-75
22335895-3	2012	Based on information obtained from a structure-activity relationship study previously conducted for an acridine series of haspin inhibitors in conjunction with in silico docking using a recently disclosed crystal structure of the kinase, harmine analogs were designed that resulted in significantly increased haspin kinase inhibitory potency.	Acridines	103-111	histone H3 associated protein kinase	Mus musculus	309-315
22105760-2	2012	Herein, several protocols that can effect the regioselective arylation and alkylation of acridines at the C-4 and C-9 positions are described.	Acridines	89-98	complement C4A (Rodgers blood group)	Homo sapiens	106-109
22105760-2	2012	Herein, several protocols that can effect the regioselective arylation and alkylation of acridines at the C-4 and C-9 positions are described.	Acridines	89-98	complement C9	Homo sapiens	114-117
21895182-8	2011	For the acridine cation our calculated pathway for the loss of C(2)H(2) leads to the 3-ethynylquinoline cation, and the loss of HCN leads to the biphenylene cation.	Acridines	8-16	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	128-131
20942468-3	2010	Laser excitation at 514.5 nm within the red part of the plasmon band leads to intense and reproducible SERS spectra of acridine, used as the probe molecule.	Acridines	119-127	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	103-107
21576023-0	2011	Exploration of acridine scaffold as a potentially interesting scaffold for discovering novel multi-target VEGFR-2 and Src kinase inhibitors.	Acridines	15-23	kinase insert domain receptor	Homo sapiens	106-113
21576023-0	2011	Exploration of acridine scaffold as a potentially interesting scaffold for discovering novel multi-target VEGFR-2 and Src kinase inhibitors.	Acridines	15-23	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	118-121
21576023-4	2011	By using molecular docking and SVM virtual screening methods and based on subsequent synthesis and bioassay studies, we identified 9-aminoacridine derivatives with an acridine scaffold as potentially interesting novel dual VEGFR-2 and Src inhibitors.	Acridines	138-146	kinase insert domain receptor	Homo sapiens	223-230
21576023-4	2011	By using molecular docking and SVM virtual screening methods and based on subsequent synthesis and bioassay studies, we identified 9-aminoacridine derivatives with an acridine scaffold as potentially interesting novel dual VEGFR-2 and Src inhibitors.	Acridines	138-146	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	235-238
21576023-11	2011	Our study suggested that acridine scaffold is a potentially interesting scaffold for developing novel multi-target kinase inhibitors such as VEGFR-2 and Src dual inhibitors.	Acridines	25-33	kinase insert domain receptor	Homo sapiens	141-148
21576023-11	2011	Our study suggested that acridine scaffold is a potentially interesting scaffold for developing novel multi-target kinase inhibitors such as VEGFR-2 and Src dual inhibitors.	Acridines	25-33	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	153-156
20309859-0	2011	Study on the interaction between human serum albumin and a novel bioactive acridine derivative using optical spectroscopy.	Acridines	75-83	albumin	Homo sapiens	39-52
21276838-0	2011	Structure-activity relationship of acridine derivatives to amyloid aggregation of lysozyme.	Acridines	35-43	lysozyme	Homo sapiens	82-90
21276838-2	2011	METHODS: Spectroscopic and atomic force microscopy were used to determine the ability of acridines to affect amyloid aggregation of lysozyme.	Acridines	89-98	lysozyme	Homo sapiens	132-140
21276838-3	2011	RESULTS: We have studied the effect of acridine derivatives on the amyloid aggregation of lysozyme to investigate the acridine structure-activity relationship.	Acridines	39-47	lysozyme	Homo sapiens	90-98
21276838-3	2011	RESULTS: We have studied the effect of acridine derivatives on the amyloid aggregation of lysozyme to investigate the acridine structure-activity relationship.	Acridines	118-126	lysozyme	Homo sapiens	90-98
21141881-2	2011	Preferential binding of the P- or M-helical conformer of bilirubin to dehydrogenases, catalase, alkaline phosphatase, and alpha-chymotrypsin is responsible for the characteristic exciton CD couplet that undergoes remarkable changes upon the addition of enzymatic cofactors (NADH, AMP) and an inhibitor (acridine).	Acridines	303-311	catalase	Homo sapiens	86-94
21441615-11	2011	IL-5 production increased only in blood stimulated with a high level of acridine (33 muM), whereas IL-6 production was less specifically stimulated (p<0.05).	Acridines	72-80	interleukin 5	Homo sapiens	0-4
21441615-12	2011	Because IL-5 is the most potent stimulating factor of the eosinophils, we suggest that the potential helper effect of valproate and acridine can lead to hypersensitive reactions to carbamazepine in the context of the humoral immune response.	Acridines	132-140	interleukin 5	Homo sapiens	8-12
21126029-4	2010	In the study of interaction of the model protein human serum albumin (HSA) with acridine derivatives, acridine yellow (AY) and proflavin (PF(+)), conventional spectroscopic tools along with docking study have been used to decipher the binding mechanism, and laser flash photolysis technique with an associated magnetic field (MF) has been used to explore PET.	Acridines	80-88	albumin	Homo sapiens	55-68
20942468-4	2010	From SERS measurements at different pH values, it was possible to determine the apparent pK(a) of acridine and to obtain specific surface properties of the film.	Acridines	98-106	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	5-9
19601641-3	2009	HEX residue reacts with ammonium hydroxide yielding acridine derivative, which has differed UV-VIS and fluorescent properties compared to HEX.	Acridines	52-60	hematopoietically expressed homeobox	Homo sapiens	0-3
20836251-0	2010	Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors.	Acridines	41-49	histone H3 associated protein kinase	Homo sapiens	61-67
20836251-0	2010	Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors.	Acridines	41-49	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	72-77
20836251-3	2010	A high throughput screen of approximately 140,000 compounds identified an acridine analog as a potent haspin kinase inhibitor.	Acridines	74-82	histone H3 associated protein kinase	Homo sapiens	102-108
20836251-5	2010	An optimization study of the acridine series revealed that the structure-activity relationship (SAR) of the acridine series for haspin and DYRK2 inhibition had many similarities.	Acridines	29-37	histone H3 associated protein kinase	Homo sapiens	128-134
20836251-5	2010	An optimization study of the acridine series revealed that the structure-activity relationship (SAR) of the acridine series for haspin and DYRK2 inhibition had many similarities.	Acridines	29-37	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	139-144
20836251-5	2010	An optimization study of the acridine series revealed that the structure-activity relationship (SAR) of the acridine series for haspin and DYRK2 inhibition had many similarities.	Acridines	108-116	histone H3 associated protein kinase	Homo sapiens	128-134
20836251-5	2010	An optimization study of the acridine series revealed that the structure-activity relationship (SAR) of the acridine series for haspin and DYRK2 inhibition had many similarities.	Acridines	108-116	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	139-144
20175992-1	2010	Selective binding of the wild type tumor suppressor protein p53 to negatively and positively supercoiled (sc) DNA was studied using intercalative drugs chloroquine (CQ), ethidium bromide, acridine derivatives and doxorubicin as a modulators of the level of DNA supercoiling.	Acridines	188-196	tumor protein p53	Homo sapiens	60-63
19968269-2	2010	Polyacridine peptides of the general formula (Acr-X)(n)-Cys were prepared by solid-phase peptide synthesis, where Acr is Lys modified on its epsilon-amine with acridine, X is Arg, Leu, or Lys and n is 2, 3, or 4 repeats.	Acridines	4-12	acrosin	Homo sapiens	46-49
19968269-2	2010	Polyacridine peptides of the general formula (Acr-X)(n)-Cys were prepared by solid-phase peptide synthesis, where Acr is Lys modified on its epsilon-amine with acridine, X is Arg, Leu, or Lys and n is 2, 3, or 4 repeats.	Acridines	4-12	acrosin	Homo sapiens	114-117
20648265-1	2010	New pyrazolyl-diamine ligands with acridine derivatives at the 4-position of the pyrazolyl ring were synthesized and characterized (L1 and L2).	Acridines	35-43	L1 cell adhesion molecule	Mus musculus	132-141
20222700-1	2010	The reaction of 2-aminoaryl ketones and arynes generated by the treatment of various o-(trimethylsilyl)aryl triflates with CsF results in [4 + 2] annulation to afford substituted acridines in good yields.	Acridines	179-188	colony stimulating factor 2	Homo sapiens	123-126
19601641-3	2009	HEX residue reacts with ammonium hydroxide yielding acridine derivative, which has differed UV-VIS and fluorescent properties compared to HEX.	Acridines	52-60	hematopoietically expressed homeobox	Homo sapiens	138-141
16261217-2	2005	METHODS: The ends of TFO were modified with manganese porphyrin and acridine; At 37 degrees C and pH 7.4 condition in vitro, TFO modified with manganese porphyrin and acridine were bound with 32P labeled HBV DNA fragments, the affinity and specificity binding to target sequence were tested by electrophoretic mobility shift and DNase 1 footprinting assays, the ability to cleave HBV DNA fractions was observed with cleavage experiments.	Acridines	68-76	deoxyribonuclease 1	Homo sapiens	329-336
19358883-3	2009	However, acridine, a representative photo-irritant, augmented CD86 and CD54 expression on THP-1 cells, apparently via induction of reactive oxygen species (ROS).	Acridines	9-17	CD86 molecule	Homo sapiens	62-66
19358883-3	2009	However, acridine, a representative photo-irritant, augmented CD86 and CD54 expression on THP-1 cells, apparently via induction of reactive oxygen species (ROS).	Acridines	9-17	intercellular adhesion molecule 1	Homo sapiens	71-75
19358883-3	2009	However, acridine, a representative photo-irritant, augmented CD86 and CD54 expression on THP-1 cells, apparently via induction of reactive oxygen species (ROS).	Acridines	9-17	GLI family zinc finger 2	Homo sapiens	90-95
19198157-4	2008	Specificity of action on MAO, form A, of four irreversible inhibitors--acridine derivative--has been established; the specificity for the mink liver MAO was several times higher than for the rat liver MAO.	Acridines	71-79	monoamine oxidase A	Rattus norvegicus	25-28
19198157-4	2008	Specificity of action on MAO, form A, of four irreversible inhibitors--acridine derivative--has been established; the specificity for the mink liver MAO was several times higher than for the rat liver MAO.	Acridines	71-79	monoamine oxidase A	Rattus norvegicus	149-152
19198157-4	2008	Specificity of action on MAO, form A, of four irreversible inhibitors--acridine derivative--has been established; the specificity for the mink liver MAO was several times higher than for the rat liver MAO.	Acridines	71-79	monoamine oxidase A	Rattus norvegicus	149-152
19251825-3	2009	To identify the IA residues essential for substrate recognition by ABCG2, we here explored the ability of ABCG2 to extrude and confer resistance to a series of 23 IAs differing at defined residue(s) surrounding their common 10-azaanthracene structure.	Acridines	224-240	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	106-111
19251825-9	2009	The possible clinical implications for the future design of novel acridines that overcome ABCG2-dependent multidrug resistance are discussed.	Acridines	66-75	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	90-95
19081949-6	2009	The highest degrees of selectivity were observed towards the N-ras quadruplex by compounds capable of forming simultaneous contacts with their acridine and peptide moieties.	Acridines	143-151	NRAS proto-oncogene, GTPase	Homo sapiens	61-66
18330854-7	2008	This work suggests that assembling multiple copies of acridine moieties to a central scaffold, for multiple interactions, is a promising strategy for the engineering of inhibitors against Abeta fibril formation.	Acridines	54-62	amyloid beta precursor protein	Homo sapiens	188-193
17209120-0	2007	Differential selection of acridine resistance mutations in human DNA topoisomerase IIbeta is dependent on the acridine structure.	Acridines	26-34	DNA topoisomerase II beta	Homo sapiens	65-89
17209120-0	2007	Differential selection of acridine resistance mutations in human DNA topoisomerase IIbeta is dependent on the acridine structure.	Acridines	110-118	DNA topoisomerase II beta	Homo sapiens	65-89
16261217-2	2005	METHODS: The ends of TFO were modified with manganese porphyrin and acridine; At 37 degrees C and pH 7.4 condition in vitro, TFO modified with manganese porphyrin and acridine were bound with 32P labeled HBV DNA fragments, the affinity and specificity binding to target sequence were tested by electrophoretic mobility shift and DNase 1 footprinting assays, the ability to cleave HBV DNA fractions was observed with cleavage experiments.	Acridines	167-175	deoxyribonuclease 1	Homo sapiens	329-336
16177561-0	2005	Acridine derivatives activate p53 and induce tumor cell death through Bax.	Acridines	0-8	tumor protein p53	Homo sapiens	30-33
16177561-0	2005	Acridine derivatives activate p53 and induce tumor cell death through Bax.	Acridines	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	70-73
16177561-4	2005	We also found that several randomly chosen acridine derivatives, including 9-aminoacridine, amsacrine, quinacrine and acridine orange, induced p53 transcriptional activity.	Acridines	43-51	tumor protein p53	Homo sapiens	143-146
16177561-5	2005	All these acridine derivatives stabilized p53 protein by blocking its ubiquitination, without phosphorylation of ser15 or ser20 on p53.	Acridines	10-18	tumor protein p53	Homo sapiens	42-45
16177561-6	2005	Furthermore, acridine derivatives induced p53-dependent cell death.	Acridines	13-21	tumor protein p53	Homo sapiens	42-45
16177561-7	2005	Knockout of Bax, a p53 target and a key cell death inducer in both intrinsic and extrinsic apoptotic pathways, blocked acridine derivatives from inducing cell death.	Acridines	119-127	BCL2 associated X, apoptosis regulator	Homo sapiens	12-15
16177561-7	2005	Knockout of Bax, a p53 target and a key cell death inducer in both intrinsic and extrinsic apoptotic pathways, blocked acridine derivatives from inducing cell death.	Acridines	119-127	tumor protein p53	Homo sapiens	19-22
16177561-9	2005	Our results reveal that DNA-intercalating acridine derivatives can induce p53 stabilization by a manner similar to CP-31398.	Acridines	42-50	tumor protein p53	Homo sapiens	74-77
16120190-0	2005	Inhibition of human CYP1A2 oxidation of 5,6-dimethyl-xanthenone-4-acetic acid by acridines: a molecular modelling study.	Acridines	81-90	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	20-26
16120190-2	2005	The aim of the present study was to investigate the structural requirements for the inhibition of 6-methyl-hydroxylation of the antitumour agent 5,6-dimethyl-xanthenone-4-acetic acid (DMXAA) by acridine analogues and use a CYP1A2 homology model to provide some insight into this interaction.	Acridines	194-202	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	223-229
16120190-5	2005	Some of the acridines were also tested for their ability to inhibit the CYP1A2-mediated 7-ethoxyresorufin O-de-ethylation.	Acridines	12-21	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	72-78
16120190-9	2005	Similar structural trends were observed for the inhibition of O-de-ethylation of 7-ethoxyresorufin by acridines, supporting the involvement of CYP1A2 in DMXAA 6-methyl hydroxylation.	Acridines	102-111	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	143-149
16298943-0	2005	EGF-receptor targeted liposomes with boronated acridine: growth inhibition of cultured glioma cells after neutron irradiation.	Acridines	47-55	epidermal growth factor receptor	Homo sapiens	0-12
15198606-2	2004	Photoinduced electron transfer from a variety of electron donors including alkylbenzenes to the singlet excited state of acridine and pyrene is accelerated significantly by the presence of scandium triflate [Sc(OTf)(3)] in acetonitrile, whereas no photoinduced electron transfer from alkylbenzenes to the singlet excited state of acridine or pyrene takes place in the absence of Sc(OTf)(3).	Acridines	121-129	POU class 5 homeobox 1	Homo sapiens	208-218
16049028-4	2005	In vitro a stable triplex was formed with the TFO-acridine conjugate: by SPR measurements at 37 degrees C and neutral pH, the dissociation equilibrium constant was found in the nanomolar range and the triplex half-life approximately 10 h (50-fold longer compared with the unconjugated TFO/LNA).	Acridines	50-58	sepiapterin reductase	Homo sapiens	73-76
15198606-7	2004	The Sc(OTf)(3)-promoted photoinduced electron transfer from hexamethylbenzene to the singlet excited state of acridine or pyrene leads to efficient oxygenation of hexamethylbenzene to produce pentamethylbenzyl alcohol which is further oxygenated under prolonged photoirradiation of an O(2)-saturated acetonitrile solution of hexamethylbenzene in the presence of acridine or pyrene which acts as a photocatalyst together with Sc(OTf)(3).	Acridines	362-370	POU class 5 homeobox 1	Homo sapiens	4-14
15198606-7	2004	The Sc(OTf)(3)-promoted photoinduced electron transfer from hexamethylbenzene to the singlet excited state of acridine or pyrene leads to efficient oxygenation of hexamethylbenzene to produce pentamethylbenzyl alcohol which is further oxygenated under prolonged photoirradiation of an O(2)-saturated acetonitrile solution of hexamethylbenzene in the presence of acridine or pyrene which acts as a photocatalyst together with Sc(OTf)(3).	Acridines	362-370	POU class 5 homeobox 1	Homo sapiens	425-435
15198606-2	2004	Photoinduced electron transfer from a variety of electron donors including alkylbenzenes to the singlet excited state of acridine and pyrene is accelerated significantly by the presence of scandium triflate [Sc(OTf)(3)] in acetonitrile, whereas no photoinduced electron transfer from alkylbenzenes to the singlet excited state of acridine or pyrene takes place in the absence of Sc(OTf)(3).	Acridines	121-129	POU class 5 homeobox 1	Homo sapiens	208-217
15198606-2	2004	Photoinduced electron transfer from a variety of electron donors including alkylbenzenes to the singlet excited state of acridine and pyrene is accelerated significantly by the presence of scandium triflate [Sc(OTf)(3)] in acetonitrile, whereas no photoinduced electron transfer from alkylbenzenes to the singlet excited state of acridine or pyrene takes place in the absence of Sc(OTf)(3).	Acridines	330-338	POU class 5 homeobox 1	Homo sapiens	208-218
15198606-2	2004	Photoinduced electron transfer from a variety of electron donors including alkylbenzenes to the singlet excited state of acridine and pyrene is accelerated significantly by the presence of scandium triflate [Sc(OTf)(3)] in acetonitrile, whereas no photoinduced electron transfer from alkylbenzenes to the singlet excited state of acridine or pyrene takes place in the absence of Sc(OTf)(3).	Acridines	330-338	POU class 5 homeobox 1	Homo sapiens	208-217
15198606-3	2004	The rate constants of the Sc(OTf)(3)-promoted photoinduced electron-transfer reactions (k(et)) of acridine to afford the complex between acridine radical anion and Sc(OTf)(3) remain constant under the conditions such that all the acridine molecules form the complex with Sc(OTf)(3).	Acridines	98-106	POU class 5 homeobox 1	Homo sapiens	26-35
15198606-3	2004	The rate constants of the Sc(OTf)(3)-promoted photoinduced electron-transfer reactions (k(et)) of acridine to afford the complex between acridine radical anion and Sc(OTf)(3) remain constant under the conditions such that all the acridine molecules form the complex with Sc(OTf)(3).	Acridines	98-106	POU class 5 homeobox 1	Homo sapiens	164-173
15198606-3	2004	The rate constants of the Sc(OTf)(3)-promoted photoinduced electron-transfer reactions (k(et)) of acridine to afford the complex between acridine radical anion and Sc(OTf)(3) remain constant under the conditions such that all the acridine molecules form the complex with Sc(OTf)(3).	Acridines	98-106	POU class 5 homeobox 1	Homo sapiens	26-36
15198606-3	2004	The rate constants of the Sc(OTf)(3)-promoted photoinduced electron-transfer reactions (k(et)) of acridine to afford the complex between acridine radical anion and Sc(OTf)(3) remain constant under the conditions such that all the acridine molecules form the complex with Sc(OTf)(3).	Acridines	137-145	POU class 5 homeobox 1	Homo sapiens	26-35
15198606-3	2004	The rate constants of the Sc(OTf)(3)-promoted photoinduced electron-transfer reactions (k(et)) of acridine to afford the complex between acridine radical anion and Sc(OTf)(3) remain constant under the conditions such that all the acridine molecules form the complex with Sc(OTf)(3).	Acridines	137-145	POU class 5 homeobox 1	Homo sapiens	164-173
15198606-3	2004	The rate constants of the Sc(OTf)(3)-promoted photoinduced electron-transfer reactions (k(et)) of acridine to afford the complex between acridine radical anion and Sc(OTf)(3) remain constant under the conditions such that all the acridine molecules form the complex with Sc(OTf)(3).	Acridines	137-145	POU class 5 homeobox 1	Homo sapiens	26-36
15198606-4	2004	In contrast to the case of acridine, the k(et) value of the Sc(OTf)(3)-promoted photoinduced electron transfer of pyrene increases with an increase in concentration of Sc(OTf)(3) to exhibit first-order dependence on [Sc(OTf)(3)] at low concentrations, changing to second-order dependence at high concentrations.	Acridines	27-35	POU class 5 homeobox 1	Homo sapiens	60-70
15198606-4	2004	In contrast to the case of acridine, the k(et) value of the Sc(OTf)(3)-promoted photoinduced electron transfer of pyrene increases with an increase in concentration of Sc(OTf)(3) to exhibit first-order dependence on [Sc(OTf)(3)] at low concentrations, changing to second-order dependence at high concentrations.	Acridines	27-35	POU class 5 homeobox 1	Homo sapiens	60-69
15198606-4	2004	In contrast to the case of acridine, the k(et) value of the Sc(OTf)(3)-promoted photoinduced electron transfer of pyrene increases with an increase in concentration of Sc(OTf)(3) to exhibit first-order dependence on [Sc(OTf)(3)] at low concentrations, changing to second-order dependence at high concentrations.	Acridines	27-35	POU class 5 homeobox 1	Homo sapiens	168-178
15198606-6	2004	The positive shifts of the one-electron redox potentials for the couple between the singlet excited state and the ground-state radical anion of acridine and pyrene in the presence of Sc(OTf)(3) as compared to those in the absence of Sc(OTf)(3) have been determined by adapting the free energy relationship for the photoinduced electron-transfer reactions.	Acridines	144-152	POU class 5 homeobox 1	Homo sapiens	183-193
15198606-6	2004	The positive shifts of the one-electron redox potentials for the couple between the singlet excited state and the ground-state radical anion of acridine and pyrene in the presence of Sc(OTf)(3) as compared to those in the absence of Sc(OTf)(3) have been determined by adapting the free energy relationship for the photoinduced electron-transfer reactions.	Acridines	144-152	POU class 5 homeobox 1	Homo sapiens	233-243
15198606-7	2004	The Sc(OTf)(3)-promoted photoinduced electron transfer from hexamethylbenzene to the singlet excited state of acridine or pyrene leads to efficient oxygenation of hexamethylbenzene to produce pentamethylbenzyl alcohol which is further oxygenated under prolonged photoirradiation of an O(2)-saturated acetonitrile solution of hexamethylbenzene in the presence of acridine or pyrene which acts as a photocatalyst together with Sc(OTf)(3).	Acridines	110-118	POU class 5 homeobox 1	Homo sapiens	4-14
15198606-7	2004	The Sc(OTf)(3)-promoted photoinduced electron transfer from hexamethylbenzene to the singlet excited state of acridine or pyrene leads to efficient oxygenation of hexamethylbenzene to produce pentamethylbenzyl alcohol which is further oxygenated under prolonged photoirradiation of an O(2)-saturated acetonitrile solution of hexamethylbenzene in the presence of acridine or pyrene which acts as a photocatalyst together with Sc(OTf)(3).	Acridines	110-118	POU class 5 homeobox 1	Homo sapiens	425-435
14677152-3	2003	In radioligand binding studies on human Y(5) receptor expressing HEC-1B cells the substances labelled with acridine (K(i) 311 nM) and NBD (K(i) > 1000 nM) proved to be moderately active or inactive, respectively.	Acridines	107-115	neuropeptide Y receptor Y5	Homo sapiens	40-53
14677152-3	2003	In radioligand binding studies on human Y(5) receptor expressing HEC-1B cells the substances labelled with acridine (K(i) 311 nM) and NBD (K(i) > 1000 nM) proved to be moderately active or inactive, respectively.	Acridines	107-115	NDC80 kinetochore complex component	Homo sapiens	65-70
14516190-0	2003	RNA-ligand interactions: affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element.	Acridines	79-87	Rev	Human immunodeficiency virus 1	112-115
10570059-0	1999	Murine transgenic cells lacking DNA topoisomerase IIbeta are resistant to acridines and mitoxantrone: analysis of cytotoxicity and cleavable complex formation.	Acridines	74-83	ATPase, class II, type 9B	Mus musculus	50-56
12210987-5	2002	Here we investigate the ability of a library of structurally diverse peptide-acridine conjugates (PACs) to target a complex formed between the dsRNA binding domain (dsRBD) of PKR and a viral RNA inhibitor.	Acridines	77-85	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	175-178
12236783-0	2002	Acridine conjugates of 3-clip-phen: influence of the linker on the synthesis and the DNA cleavage activity of their copper complexes.	Acridines	0-8	CAP-Gly domain containing linker protein 1	Homo sapiens	25-29
12236783-3	2002	The results indicated that (i) the coupling of 3-Clip-Phen to an acridine derivative increased the DNA cleavage efficiency of the copper complexes, (ii) the acridine derivatives were more active than 6-chloro-2-methoxyacridine derivatives, (iii) the linker length influenced cleavage efficiency, the highest DNA cleavage activity being obtained for an aminocaproic spacer.	Acridines	65-73	CAP-Gly domain containing linker protein 1	Homo sapiens	49-53
12236783-3	2002	The results indicated that (i) the coupling of 3-Clip-Phen to an acridine derivative increased the DNA cleavage efficiency of the copper complexes, (ii) the acridine derivatives were more active than 6-chloro-2-methoxyacridine derivatives, (iii) the linker length influenced cleavage efficiency, the highest DNA cleavage activity being obtained for an aminocaproic spacer.	Acridines	157-165	CAP-Gly domain containing linker protein 1	Homo sapiens	49-53
11453734-0	2001	trans-3,4-dihydroxy-anti-1,2-epoxy-1,2,3,4-tetrahydrodi- benz[a,j]acridine involvement in dibenz[a,j]acridine DNA adduct formation in mouse skin consistent with Ha-ras mutation patterns in tumors.	Acridines	66-74	Harvey rat sarcoma virus oncogene	Mus musculus	161-167
11453734-0	2001	trans-3,4-dihydroxy-anti-1,2-epoxy-1,2,3,4-tetrahydrodi- benz[a,j]acridine involvement in dibenz[a,j]acridine DNA adduct formation in mouse skin consistent with Ha-ras mutation patterns in tumors.	Acridines	101-109	Harvey rat sarcoma virus oncogene	Mus musculus	161-167
12431079-5	2002	Thus, Mo(PMe3)6 reacts with pyridine to give an eta2-pyridyl derivative [eta2-(C5H4N)]Mo(PMe3)4H as a result of alpha-C-H bond cleavage, whereas quinoline and acridine give products of the type (eta6-ArH)Mo(PMe3)3 in which both ligands coordinate in an eta6-manner.	Acridines	159-167	DNA polymerase iota	Homo sapiens	48-52
12431079-5	2002	Thus, Mo(PMe3)6 reacts with pyridine to give an eta2-pyridyl derivative [eta2-(C5H4N)]Mo(PMe3)4H as a result of alpha-C-H bond cleavage, whereas quinoline and acridine give products of the type (eta6-ArH)Mo(PMe3)3 in which both ligands coordinate in an eta6-manner.	Acridines	159-167	DNA polymerase iota	Homo sapiens	73-77
12121128-3	2002	EGF was conjugated to the distal end of PEG-DSPE lipid molecules in a micellar solution and the EGF-PEG-DSPE lipids were then transferred to preformed liposomes, either empty or containing the DNA-binding compound, water soluble acridine, WSA.	Acridines	229-237	epidermal growth factor	Homo sapiens	0-3
12034846-0	2002	Acridine-modified, clamp-forming antisense oligonucleotides synergize with cisplatin to inhibit c-Myc expression and B16-F0 tumor progression.	Acridines	0-8	myelocytomatosis oncogene	Mus musculus	98-101
12034846-2	2002	We have targeted three polypurine sequences within the mouse myc mRNA with acridine-modified, clamp-forming antisense oligonucleotides (AS ODNs) in an effort to inhibit growth of murine melanoma cells.	Acridines	75-83	myelocytomatosis oncogene	Mus musculus	61-64
11735402-6	2001	Here, we show that trisubstituted acridine ligands are potent inhibitors of the helicase activity of the BLM and WRN proteins on both G-quadruplex and B-form DNA substrates.	Acridines	34-42	helicase for meiosis 1	Homo sapiens	80-88
11735402-6	2001	Here, we show that trisubstituted acridine ligands are potent inhibitors of the helicase activity of the BLM and WRN proteins on both G-quadruplex and B-form DNA substrates.	Acridines	34-42	BLM RecQ like helicase	Homo sapiens	105-108
12375883-3	2001	The acridine-linker moiety occupies the position where different glucoside moieties, dispensable for activity, are normally linked to epiDPT in the well known epipodophyllotoxins VP-16 and VM-26.	Acridines	4-12	host cell factor C1	Homo sapiens	179-184
11249555-4	1999	It is structurally dissimilar from other established cholinesterase inhibitors, namely THA (an acridine compound) and the carbamates, physostigmine and rivastigmine and has a pharmacokinetic and tolerability profile distinct from these agents.	Acridines	95-103	butyrylcholinesterase	Homo sapiens	53-67
10428376-1	1999	We investigated the interaction of a highly potent acridine-based tat-antagonist with the TAR RNA of HIV-1.	Acridines	51-59	RNA binding motif protein 8A	Homo sapiens	90-93
9989475-2	1999	Tetrahydroaminoacridine (tacrine, Cognex), a simple acridine, is a reversible inhibitor of cholinesterase activity available for the symptomatic treatment of Alzheimer"s disease.	Acridines	15-23	butyrylcholinesterase	Homo sapiens	91-105
8060530-0	1994	Differential inhibition of cyclic AMP-dependent protein kinase, myosin light chain kinase and protein kinase C by azaacridine and acridine derivatives.	Acridines	117-125	cyclin dependent kinase 7	Homo sapiens	27-62
9744573-8	1998	All tested acridines protected cells against DNA breakage induced by VP-16, but the extent of protection varied significantly.	Acridines	11-20	host cell factor C1	Homo sapiens	69-74
9398183-2	1997	The Y337 (F330) in mammalian acetylcholinesterase, which is replaced by A328 in human butyrylcholinesterase, is implicated in the binding of ligands such as huperzine A, edrophonium, and acridines and one end of bisquaternary compounds such as BW284C51 and decamethonium.	Acridines	187-196	acetylcholinesterase (Cartwright blood group)	Homo sapiens	29-49
9398183-2	1997	The Y337 (F330) in mammalian acetylcholinesterase, which is replaced by A328 in human butyrylcholinesterase, is implicated in the binding of ligands such as huperzine A, edrophonium, and acridines and one end of bisquaternary compounds such as BW284C51 and decamethonium.	Acridines	187-196	butyrylcholinesterase	Homo sapiens	86-107
9177837-0	1997	A 15-base acridine-conjugated oligodeoxynucleotide forms triplex DNA with its IL-2R alpha promoter target with greatly improved avidity.	Acridines	10-18	interleukin 2 receptor subunit alpha	Homo sapiens	78-89
9125503-5	1997	The principal difference between the major and the minor complexes consists of a 180 degrees rotation of the acridine ring around the Acr-C-N bond within the same intercalation site.	Acridines	109-117	acrosin	Homo sapiens	134-137
8527921-1	1995	Acridine ligand affinity chromatography is an effective means of acetylcholinesterase (AChE) purification.	Acridines	0-8	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-85
8527921-1	1995	Acridine ligand affinity chromatography is an effective means of acetylcholinesterase (AChE) purification.	Acridines	0-8	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-91
8527921-3	1995	We have developed an acridine ligand affinity resin that is easy to produce, inexpensive, and selective for AChE over butyrylcholinesterase.	Acridines	21-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-112
7872693-3	1994	Different acridines were systematically synthesized and their effects were tested on endotoxin and Staphylococcus aureus-induced TNF production by human leukocytes.	Acridines	10-19	tumor necrosis factor	Homo sapiens	129-132
7872693-9	1994	The exact mechanism of the suppression of TNF synthesis by acridines remains to be elucidated, but might be useful in the screening and evaluation of their anticancer properties and antimalarial effects.	Acridines	59-68	tumor necrosis factor	Homo sapiens	42-45
7765360-1	1994	The inhibition of wheat Ca(2+)-dependent protein kinase (CDPK) by substituted acridines and substituted 5-, 6-, 7- and 8-azaacridines (5-AA, 6-AA, 7-AA and 8-AA) was examined.	Acridines	78-87	calcium-dependent protein kinase 19	Triticum aestivum	24-55
7765360-1	1994	The inhibition of wheat Ca(2+)-dependent protein kinase (CDPK) by substituted acridines and substituted 5-, 6-, 7- and 8-azaacridines (5-AA, 6-AA, 7-AA and 8-AA) was examined.	Acridines	78-87	calcium-dependent protein kinase 19	Triticum aestivum	57-61
7765360-2	1994	Of a total of 71 substituted acridines and azaacridines examined, only 20 have IC50 values for wheat CDPK of less than 200 microM.	Acridines	29-38	calcium-dependent protein kinase 19	Triticum aestivum	101-105
8060530-7	1994	All other acridines and azaacridines examined are non-competitive inhibitors of both MLCK and cAK with respect to both ATP and peptide substrate.	Acridines	10-19	myosin light chain kinase	Homo sapiens	85-89
8060530-7	1994	All other acridines and azaacridines examined are non-competitive inhibitors of both MLCK and cAK with respect to both ATP and peptide substrate.	Acridines	10-19	cyclin dependent kinase 7	Homo sapiens	94-97
7479062-7	1995	GA-alpha oligonucleotides covalently conjugated to acridine were similarly unable to demonstrate triplex formation.	Acridines	51-59	alpha glucosidase	Homo sapiens	0-8
8060530-0	1994	Differential inhibition of cyclic AMP-dependent protein kinase, myosin light chain kinase and protein kinase C by azaacridine and acridine derivatives.	Acridines	117-125	myosin light chain kinase	Homo sapiens	64-89
3271463-2	1987	Both are in the free base form and have an intramolecular-hydrogen bond between N10 of the acridine and the nitrogen atom of the carboxamide substituent.	Acridines	91-99	nuclear receptor subfamily 4 group A member 1	Homo sapiens	80-83
8110987-2	1993	The possible mechanism of action of acridine and structurally related tricyclic compounds was studied on the bivalent cation content of bacterial membrane, rat brain acetylcholinesterase and some tissue proteases in model experiments.	Acridines	36-44	acetylcholinesterase	Rattus norvegicus	166-186
1379732-2	1992	The substrate binding capability of RNase A was mimicked by the intercalator, acridine.	Acridines	78-86	ribonuclease A family member 1, pancreatic	Homo sapiens	36-43
1538717-1	1992	This paper examines inhibition of acetylcholinesterase (AchE) and butyrylcholinesterase (BuchE) by tetrahydroaminoacridine (THA), an acridine analog under consideration for palliative treatment of Alzheimer"s dementia.	Acridines	114-122	acetylcholinesterase (Cartwright blood group)	Homo sapiens	34-54
1538717-1	1992	This paper examines inhibition of acetylcholinesterase (AchE) and butyrylcholinesterase (BuchE) by tetrahydroaminoacridine (THA), an acridine analog under consideration for palliative treatment of Alzheimer"s dementia.	Acridines	114-122	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-60
1538717-1	1992	This paper examines inhibition of acetylcholinesterase (AchE) and butyrylcholinesterase (BuchE) by tetrahydroaminoacridine (THA), an acridine analog under consideration for palliative treatment of Alzheimer"s dementia.	Acridines	114-122	butyrylcholinesterase	Homo sapiens	66-87
1538717-1	1992	This paper examines inhibition of acetylcholinesterase (AchE) and butyrylcholinesterase (BuchE) by tetrahydroaminoacridine (THA), an acridine analog under consideration for palliative treatment of Alzheimer"s dementia.	Acridines	114-122	butyrylcholinesterase	Homo sapiens	89-94
8314536-2	1993	Both the triplex-forming oligonucleotide and its acridine conjugate are shown to form triple-stranded DNA at the site of the target sequence by DNase 1 footprinting.	Acridines	49-57	deoxyribonuclease 1	Homo sapiens	144-151
1300633-1	1992	Simple method of continual monitoring of the rat blood cholinesterase activity in vivo was used to demonstrate its inhibition following i. m. administration of acridine and carbamate inhibitors.	Acridines	160-168	butyrylcholinesterase	Rattus norvegicus	55-69
1741968-1	1991	Molecular dynamics simulations have been performed on the dinucleoside monophosphates rGpC and dCpG, the latter in its intercalation complex with the acridine drug proflavine.	Acridines	150-158	glycophorin C	Rattus norvegicus	86-90
34073721-0	2021	8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1.	Acridines	10-18	histone deacetylase 1	Homo sapiens	71-76
34073721-0	2021	8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1.	Acridines	10-18	DNA methyltransferase 1	Homo sapiens	77-82
3778864-0	1986	Nuclear magnetic resonance studies of complex formation between the oligonucleotide d(TATC) covalently linked to an acridine derivative and its complementary sequence d(GATA).	Acridines	116-124	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	169-173