PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16141212-10	2005	The other genes isolated (PBP1, UFD4, TPS1, and WHI2) may be involved in LCBP signaling.	lcbp	73-77	Pbp1p	Saccharomyces cerevisiae S288C	26-30
21910031-5	2012	The level of dihydrosphingosine 1-phosphate was increased in loss-of-function mutants (spp1) compared with wild-type (WT) plants, suggesting a role of AtSPP1 in regulating LCBP levels.	lcbp	172-176	sucrose-phosphatase 1	Arabidopsis thaliana	87-91
21910031-5	2012	The level of dihydrosphingosine 1-phosphate was increased in loss-of-function mutants (spp1) compared with wild-type (WT) plants, suggesting a role of AtSPP1 in regulating LCBP levels.	lcbp	172-176	sucrose-phosphatase 1	Arabidopsis thaliana	151-157
21910031-11	2012	We conclude that AtSPP1 is a functional LCBP phosphatase that may play a role in stomatal responses through LCBP-mediated ABA signaling.	lcbp	40-44	sucrose-phosphatase 1	Arabidopsis thaliana	17-23
18558101-1	2008	Sphingosine-1-phosphate lyase (SPL) is a highly conserved enzyme that catalyses the final step of sphingolipid degradation, namely the irreversible cleavage of the carbon chain at positions 2-3 of a long-chain base phosphate (LCBP), thereby yielding a long-chain aldehyde and phosphoethanolamine.	lcbp	226-230	sphingosine-1-phosphate lyase 1	Homo sapiens	0-29
18558101-1	2008	Sphingosine-1-phosphate lyase (SPL) is a highly conserved enzyme that catalyses the final step of sphingolipid degradation, namely the irreversible cleavage of the carbon chain at positions 2-3 of a long-chain base phosphate (LCBP), thereby yielding a long-chain aldehyde and phosphoethanolamine.	lcbp	226-230	sphingosine-1-phosphate lyase 1	Homo sapiens	31-34
16141212-10	2005	The other genes isolated (PBP1, UFD4, TPS1, and WHI2) may be involved in LCBP signaling.	lcbp	73-77	putative ubiquitin-protein ligase UFD4	Saccharomyces cerevisiae S288C	32-36
16141212-10	2005	The other genes isolated (PBP1, UFD4, TPS1, and WHI2) may be involved in LCBP signaling.	lcbp	73-77	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	38-42
16141212-10	2005	The other genes isolated (PBP1, UFD4, TPS1, and WHI2) may be involved in LCBP signaling.	lcbp	73-77	Whi2p	Saccharomyces cerevisiae S288C	48-52
12786943-10	2003	CONCLUSION: Our results suggest that the active site of Lcb3p is located in the ER lumen and, thus, the phosphate group of the LCBP is hydrolysed on the lumenal side.	lcbp	127-131	sphinganine kinase LCB3	Saccharomyces cerevisiae S288C	56-61
12459470-2	2002	To learn more about LCBPs in Saccharomyces cerevisiae, we determined the cellular location of Lcb4p, the major enzyme catalyzing LCBP synthesis.	lcbp	20-24	sphinganine kinase LCB4	Saccharomyces cerevisiae S288C	94-99
35356725-7	2022	LCBP significantly regulated the expression of antioxidant and inflammatory proteins, Bcl-2 /Bax apoptosis proteins, and the PKCalpha -NOx2 / Nox4 pathway proteins, and activated the expression of AMPK-PGC1alpha -NRF1-TFAM proteins in skeletal muscle mitochondria.	lcbp	0-4	B cell leukemia/lymphoma 2	Mus musculus	86-91
35356725-7	2022	LCBP significantly regulated the expression of antioxidant and inflammatory proteins, Bcl-2 /Bax apoptosis proteins, and the PKCalpha -NOx2 / Nox4 pathway proteins, and activated the expression of AMPK-PGC1alpha -NRF1-TFAM proteins in skeletal muscle mitochondria.	lcbp	0-4	BCL2-associated X protein	Mus musculus	93-96
35356725-7	2022	LCBP significantly regulated the expression of antioxidant and inflammatory proteins, Bcl-2 /Bax apoptosis proteins, and the PKCalpha -NOx2 / Nox4 pathway proteins, and activated the expression of AMPK-PGC1alpha -NRF1-TFAM proteins in skeletal muscle mitochondria.	lcbp	0-4	protein kinase C, alpha	Mus musculus	125-133
35356725-7	2022	LCBP significantly regulated the expression of antioxidant and inflammatory proteins, Bcl-2 /Bax apoptosis proteins, and the PKCalpha -NOx2 / Nox4 pathway proteins, and activated the expression of AMPK-PGC1alpha -NRF1-TFAM proteins in skeletal muscle mitochondria.	lcbp	0-4	cytochrome b-245, beta polypeptide	Mus musculus	135-139
35356725-7	2022	LCBP significantly regulated the expression of antioxidant and inflammatory proteins, Bcl-2 /Bax apoptosis proteins, and the PKCalpha -NOx2 / Nox4 pathway proteins, and activated the expression of AMPK-PGC1alpha -NRF1-TFAM proteins in skeletal muscle mitochondria.	lcbp	0-4	NADPH oxidase 4	Mus musculus	142-146
35356725-7	2022	LCBP significantly regulated the expression of antioxidant and inflammatory proteins, Bcl-2 /Bax apoptosis proteins, and the PKCalpha -NOx2 / Nox4 pathway proteins, and activated the expression of AMPK-PGC1alpha -NRF1-TFAM proteins in skeletal muscle mitochondria.	lcbp	0-4	nuclear respiratory factor 1	Mus musculus	213-217
35356725-7	2022	LCBP significantly regulated the expression of antioxidant and inflammatory proteins, Bcl-2 /Bax apoptosis proteins, and the PKCalpha -NOx2 / Nox4 pathway proteins, and activated the expression of AMPK-PGC1alpha -NRF1-TFAM proteins in skeletal muscle mitochondria.	lcbp	0-4	transcription factor A, mitochondrial	Mus musculus	218-222
31146527-2	2019	Currently, it is unknown whether LCBP can activate Sirtuin 1 (SIRT1) to regulate the formation of RAW264.7 macrophage foam cells.	lcbp	33-37	sirtuin 1	Mus musculus	62-67
31146527-6	2019	The results showed that treatment with 80 mug/mL LCBP significantly inhibited the accumulation of lipids in RAW264.7 macrophages induced by ox-LDL and reduced intracellular cholesterol levels by activating SIRT1 to enhance the expression of ABCA1, a cholesterol efflux gene, but not independent effect.	lcbp	49-53	sirtuin 1	Mus musculus	206-211
31146527-6	2019	The results showed that treatment with 80 mug/mL LCBP significantly inhibited the accumulation of lipids in RAW264.7 macrophages induced by ox-LDL and reduced intracellular cholesterol levels by activating SIRT1 to enhance the expression of ABCA1, a cholesterol efflux gene, but not independent effect.	lcbp	49-53	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	241-246
30563142-4	2018	The results revealed that supplementation with LCBP decreased significantly the levels of IL-2, IL-6, MCP-1, and TNF-alpha in serum, as well as endotoxin levels in both serum and liver in HFD-fed mice.	lcbp	47-51	interleukin 2	Mus musculus	90-94
30563142-4	2018	The results revealed that supplementation with LCBP decreased significantly the levels of IL-2, IL-6, MCP-1, and TNF-alpha in serum, as well as endotoxin levels in both serum and liver in HFD-fed mice.	lcbp	47-51	interleukin 6	Mus musculus	96-100
30563142-4	2018	The results revealed that supplementation with LCBP decreased significantly the levels of IL-2, IL-6, MCP-1, and TNF-alpha in serum, as well as endotoxin levels in both serum and liver in HFD-fed mice.	lcbp	47-51	mast cell protease 1	Mus musculus	102-107
30563142-4	2018	The results revealed that supplementation with LCBP decreased significantly the levels of IL-2, IL-6, MCP-1, and TNF-alpha in serum, as well as endotoxin levels in both serum and liver in HFD-fed mice.	lcbp	47-51	tumor necrosis factor	Mus musculus	113-122
12493772-8	2003	These results raise the conceptually attractive possibility that membrane-associated and cytosolic Lcb4p play distinct roles to differentially generate biosynthetic and signaling pools of LCBP.	lcbp	188-192	sphinganine kinase LCB4	Saccharomyces cerevisiae S288C	99-104
11795842-3	2001	Elimination of both the Dpll lyase and the Lcb3 phosphatase pathways by gene deletion was lethal, indicating that these enzymes regulate LCBP levels to prevent accumulation.	lcbp	137-141	sphinganine kinase LCB3	Saccharomyces cerevisiae S288C	43-47
11795842-7	2001	By regulating Lcb4 kinase activity, we found that cell death correlates with LCBP accumulation and that C18 dihydrosphingosine-l-P (DHS-P) and C20 DHS-P are most likely the killing molecules.	lcbp	77-81	sphinganine kinase LCB4	Saccharomyces cerevisiae S288C	14-18
28303405-7	2017	In comparison of WT and spp1 plants, the LCBP/LCB ratio is likely to be correlated with the degree of FB1-induced cell death determined by trypan blue staining.	lcbp	41-45	sucrose-phosphatase 1	Arabidopsis thaliana	24-28