PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30951845-10	2019	Moreover, we found that Cs-ME reduced the phosphorylation of NF-kappaB upstream signaling molecules including IkappaBalpha, IKKalpha/beta, Src, and Syk in LPS-stimulated macrophage-like RAW264.7 cells.	cs-me	24-29	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	110-122
30951845-10	2019	Moreover, we found that Cs-ME reduced the phosphorylation of NF-kappaB upstream signaling molecules including IkappaBalpha, IKKalpha/beta, Src, and Syk in LPS-stimulated macrophage-like RAW264.7 cells.	cs-me	24-29	conserved helix-loop-helix ubiquitous kinase	Mus musculus	124-137
30951845-10	2019	Moreover, we found that Cs-ME reduced the phosphorylation of NF-kappaB upstream signaling molecules including IkappaBalpha, IKKalpha/beta, Src, and Syk in LPS-stimulated macrophage-like RAW264.7 cells.	cs-me	24-29	Rous sarcoma oncogene	Mus musculus	139-142
30951845-10	2019	Moreover, we found that Cs-ME reduced the phosphorylation of NF-kappaB upstream signaling molecules including IkappaBalpha, IKKalpha/beta, Src, and Syk in LPS-stimulated macrophage-like RAW264.7 cells.	cs-me	24-29	spleen tyrosine kinase	Mus musculus	148-151
30951845-11	2019	The results of Western blot and CETSA confirmed that Src and Syk are anti-inflammatory targets of Cs-ME.	cs-me	98-103	Rous sarcoma oncogene	Mus musculus	53-56
30951845-11	2019	The results of Western blot and CETSA confirmed that Src and Syk are anti-inflammatory targets of Cs-ME.	cs-me	98-103	spleen tyrosine kinase	Mus musculus	61-64
30951845-14	2019	CONCLUSIONS: Cs-ME exhibits anti-inflammatory effects in vitro and in vivo by targeting Src and Syk in the NF-kappaB signaling pathway.	cs-me	13-18	Rous sarcoma oncogene	Mus musculus	88-91
30951845-14	2019	CONCLUSIONS: Cs-ME exhibits anti-inflammatory effects in vitro and in vivo by targeting Src and Syk in the NF-kappaB signaling pathway.	cs-me	13-18	spleen tyrosine kinase	Mus musculus	96-99
27150139-3	2016	CS-ME concentration-dependently inhibited LPS-induced tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 and IL-1beta production in RAW264.7 macrophages and mouse peritoneal macrophages.	cs-me	0-5	tumor necrosis factor	Mus musculus	54-87
27150139-3	2016	CS-ME concentration-dependently inhibited LPS-induced tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 and IL-1beta production in RAW264.7 macrophages and mouse peritoneal macrophages.	cs-me	0-5	interleukin 6	Mus musculus	92-110
27150139-3	2016	CS-ME concentration-dependently inhibited LPS-induced tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 and IL-1beta production in RAW264.7 macrophages and mouse peritoneal macrophages.	cs-me	0-5	interleukin 1 beta	Mus musculus	115-123
27150139-4	2016	Consistent with these findings, CS-ME suppressed LPS-induced expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 at protein level as well as iNOS, COX-2, TNF-alpha, IL-6, and IL-1beta at mRNA level.	cs-me	32-37	interleukin 1 beta	Mus musculus	193-201
27150139-6	2016	The anti-inflammatory properties of CS-ME might result from suppression of iNOS, COX-2, TNF-alpha, IL-6, and IL-1beta expression through downregulation of NF-kappaB and AP-1 in macrophages.	cs-me	36-41	interleukin 1 beta	Mus musculus	109-117
33777162-7	2021	PCR analysis revealed that Cs-ME diminished the expression of aging-related HYAL-1 and MMP-1 genes in UV-treated HaCaT cells.	cs-me	27-32	hyaluronidase 1	Homo sapiens	76-82
33777162-7	2021	PCR analysis revealed that Cs-ME diminished the expression of aging-related HYAL-1 and MMP-1 genes in UV-treated HaCaT cells.	cs-me	27-32	matrix metallopeptidase 1	Homo sapiens	87-92
33777162-8	2021	Elevated HYAL-1 and MMP-1 mRNA expression in H2O2-stimulated HaCaT cells was also decreased by Cs-ME, suggesting that Cs-ME exerts antiaging activity via the inhibition of ROS.	cs-me	95-100	hyaluronidase 1	Homo sapiens	9-15
33777162-8	2021	Elevated HYAL-1 and MMP-1 mRNA expression in H2O2-stimulated HaCaT cells was also decreased by Cs-ME, suggesting that Cs-ME exerts antiaging activity via the inhibition of ROS.	cs-me	118-123	hyaluronidase 1	Homo sapiens	9-15
33777162-8	2021	Elevated HYAL-1 and MMP-1 mRNA expression in H2O2-stimulated HaCaT cells was also decreased by Cs-ME, suggesting that Cs-ME exerts antiaging activity via the inhibition of ROS.	cs-me	118-123	matrix metallopeptidase 1	Homo sapiens	20-25
33777162-9	2021	Expression of skin barrier components including filaggrin and hyaluronic acid synthase-1 was increased by Cs-ME and was modulated by ERK/p38-AP-1 signaling.	cs-me	106-111	filaggrin	Homo sapiens	48-57
33777162-9	2021	Expression of skin barrier components including filaggrin and hyaluronic acid synthase-1 was increased by Cs-ME and was modulated by ERK/p38-AP-1 signaling.	cs-me	106-111	hyaluronan synthase 1	Homo sapiens	62-88
33777162-11	2021	Furthermore, Cs-ME exerts skin barrier protective ability by regulating the AP-1 signaling pathway.	cs-me	13-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-80