PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17102905-4	2007	Eniporide (3 muM) and/or lidocaine (200 muM) were administered during 5 min prior to 40 min of global ischemia and 40 min of drug free reperfusion to block the NHE and the Na(+) channel, respectively.	eniporide	0-9	sodium voltage-gated channel alpha subunit 8	Rattus norvegicus	172-185
15901744-1	2005	Eniporide (EMD 96 875) is a novel and selective inhibitor of the Na+-H+ exchange (NHE-1) inhibitor.	eniporide	0-9	solute carrier family 9 member A1	Homo sapiens	82-87
11412833-2	2001	Using this assay system, we demonstrated that the acylguanidine derivatives, cariporide and eniporide, cause selective inhibition of hNHE1 (IC50 value of 30 nM for cariporide, IC50 value of 4.5 nM for eniporide).	eniporide	92-101	solute carrier family 9 member A1	Homo sapiens	133-138
11412833-2	2001	Using this assay system, we demonstrated that the acylguanidine derivatives, cariporide and eniporide, cause selective inhibition of hNHE1 (IC50 value of 30 nM for cariporide, IC50 value of 4.5 nM for eniporide).	eniporide	201-210	solute carrier family 9 member A1	Homo sapiens	133-138
11060730-10	2000	Another NHE1 inhibitor, eniporide, is currently in Phase II clinical trial (ESCAMI) in patients with acute myocardial infarction (MI) who are given angioplasty or thrombolysis.	eniporide	24-33	solute carrier family 9 member A1	Homo sapiens	8-12
12970112-3	2003	Nhe1-/- and wild-type hearts were perfused in a Langendorff apparatus in both the absence and presence of the NHE1 inhibitor eniporide, subjected to 40 minutes of ischemia and 30 minutes of reperfusion, and the effects of genetic ablation or inhibition of NHE1 on hemodynamic, biochemical, and pathological changes were assessed.	eniporide	125-134	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	110-114
12832126-9	2003	The simultaneous replacement of the pyrazine ring by a phenyl, of the 6-chloro by a sulfomethyl led to drugs such as HOE-694, cariporide, eniporide and BIIB-513 which also selectively inhibited NHE1.	eniporide	138-147	solute carrier family 9 member A1	Homo sapiens	194-198
11959803-13	2002	These results indicate that the new structural NHE-1 inhibitor T-162559 is more potent than cariporide and eniporide and possesses a cardioprotective effect against ischaemia and reperfusion injury in rat and rabbit models.	eniporide	107-116	solute carrier family 9 member A1	Rattus norvegicus	47-52
11869836-2	2002	In contrast, recent clinical studies with the NHE inhibitors cariporide and eniporide in patients with evolving myocardial infarction (MI) and those at risk of MI have provided mixed and somewhat contradictory data.	eniporide	76-85	solute carrier family 9 member C1	Homo sapiens	46-49
11704395-4	2001	Eniporide specifically inhibits the NHE-1 isoform and has been shown to limit infarct size in experimental models.	eniporide	0-9	solute carrier family 9 member A1	Homo sapiens	36-41
11704395-11	2001	CONCLUSIONS: In this large study administration of the NHE-1 inhibitor eniporide, before reperfusion therapy in patients with acute ST elevation MI, did not limit infarct size or improve clinical outcome.	eniporide	71-80	solute carrier family 9 member A1	Homo sapiens	55-60
11514295-6	2001	Whereas neither control nor IPC-treated animals exhibited a significant reduction in IS/AAR or preservation of endothelial cell function, animals treated with the NHE inhibitor eniporide showed a marked reduction in IS/AAR and a significantly preserved endothelial cell function (P < 0.05).	eniporide	177-186	solute carrier family 9 member A1	Canis lupus familiaris	163-166
11210393-0	2001	Pharmacokinetic/pharmacodynamic evaluation of the NHE inhibitor eniporide.	eniporide	64-73	solute carrier family 9 member C1	Homo sapiens	50-53
11210393-1	2001	The aim of this study was to investigate the pharmacokinetics and pharmacodynamics of the new cardioprotective sodium/proton exchange (NHE-1) inhibitor eniporide in humans.	eniporide	152-161	solute carrier family 9 member A1	Homo sapiens	135-140
18222727-2	2008	By contrast, clinical studies with the NHE inhibitors cariporide, eniporide and zoniporide, in patients with evolving myocardial infarction and those at risk of myocardial infarction, have provided largely disappointing data.	eniporide	66-75	solute carrier family 9 member C1	Homo sapiens	39-42