PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
14725-0	1976	[Influence of dinitrophenol, octanol and toluene upon pH-dependence of ca-ATPase activity of heavy meromyosin].	Octanols	29-36	dynein axonemal heavy chain 8	Homo sapiens	74-80
14725-1	1976	It is found that dinitrophenol, octanol and toluene produce similar effects on pH-dependence of ATPase of myosin and heavy meromyosin (HMM), i.e. they decrease or remove the neutral suppression of ATPase activity.	Octanols	32-39	dynein axonemal heavy chain 8	Homo sapiens	96-102
14725-1	1976	It is found that dinitrophenol, octanol and toluene produce similar effects on pH-dependence of ATPase of myosin and heavy meromyosin (HMM), i.e. they decrease or remove the neutral suppression of ATPase activity.	Octanols	32-39	myosin heavy chain 14	Homo sapiens	106-133
14725-1	1976	It is found that dinitrophenol, octanol and toluene produce similar effects on pH-dependence of ATPase of myosin and heavy meromyosin (HMM), i.e. they decrease or remove the neutral suppression of ATPase activity.	Octanols	32-39	dynein axonemal heavy chain 8	Homo sapiens	197-203
4501117-1	1972	Conditional heterosis associated with two isoallelic forms of octanol dehydrogenase in Drosophila pseudoobscura has been detected in flies that have been (a) inbred for several generations to make the background genotype as homozygous as practicable, and (b) grown on a medium containing a small amount of octanol.	Octanols	62-69	Glycerol-3-phosphate dehydrogenase 1	Drosophila melanogaster	70-83
33218730-0	2021	Slopes and intercepts from log-log correlations of gas/particle quotient and octanol-air partition coefficient (vapor-pressure) for semi-volatile organic compounds: II.	Octanols	77-84	gastrin	Homo sapiens	51-54
4257781-0	1972	Biochemical studies of olfactory tissue: responses of ATPase activities to octanol and ascorbic acid.	Octanols	75-82	dynein axonemal heavy chain 8	Homo sapiens	54-60
14225257-3	1964	Octyl alcohol differs from the others (C(2) through C(5)) in that it has less tendency to depolarize the axon.	Octanols	0-13	complement C2	Homo sapiens	39-43
14225257-3	1964	Octyl alcohol differs from the others (C(2) through C(5)) in that it has less tendency to depolarize the axon.	Octanols	0-13	complement C5	Homo sapiens	52-56
33218730-2	2021	The logarithm of gas/particle (G/P) partition quotient (logKP) has been found to have a linear relationship with logKOA (octanol-air partition coefficient) with slope mo and intercept bo and logPL (subcooled liquid vapor pressure) with slope mp and intercept bp.	Octanols	121-128	gastrin	Homo sapiens	17-20
32512434-6	2020	Evaluation of KSS data for the 4 h extractions showed that soil type and selected HMW-PAH properties (literature based molecular weight and octanol-carbon partition coefficients) affect the amount of HMW-PAH released from soil into sebum.	Octanols	140-147	cilia and flagella associated protein 97	Homo sapiens	82-85
32512434-6	2020	Evaluation of KSS data for the 4 h extractions showed that soil type and selected HMW-PAH properties (literature based molecular weight and octanol-carbon partition coefficients) affect the amount of HMW-PAH released from soil into sebum.	Octanols	140-147	cilia and flagella associated protein 97	Homo sapiens	200-203
29478644-2	2018	Major regulations in different countries and regions identify chemicals according to their bioconcentration factor (BCF) and octanol-water partition coefficient (Kow), which frequently displays a substantial correlation with the sediment sorption coefficient (Koc).	Octanols	125-132	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	260-263
30553262-0	2018	Calculation of the water-octanol partition coefficient of cholesterol for SPC, TIP3P, and TIP4P water.	Octanols	25-32	proline rich protein gene cluster	Homo sapiens	74-77
30401619-9	2018	Overexpression of both cel-acc-1 and hco-acc-1 in both C. elegans N2 and acc-1 null mutants decreased the time for worms to initiate reversal avoidance to octanol.	Octanols	155-162	Acetylcholine-gated chloride channel subunit acc-1	Caenorhabditis elegans	41-46
29920519-18	2018	The Pdc estimated by the multi-drop method is ~ 11-fold higher than previously reported but closer to the value reported for other drugs with equivalent octanol/water partition coefficient.	Octanols	153-160	phosducin	Homo sapiens	4-7
29627972-7	2018	We found that BFRs with lower octanol and air partition coefficients tended to increase during haze and fog episodes, be removed from PM2.5 during clear episodes, or both.	Octanols	30-37	zinc finger protein, FOG family member 1	Homo sapiens	104-107
32126844-3	2020	Several methods were used to validate the formation of RHPC and RHPC-MD, such as differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, infrared spectroscopy, particle size, and zeta potential, meanwhile, their octanol-water partition coefficient, solubility, and dissolution in vitro were also evaluated.	Octanols	274-281	Rh blood group, D antigen	Rattus norvegicus	55-59
30401619-9	2018	Overexpression of both cel-acc-1 and hco-acc-1 in both C. elegans N2 and acc-1 null mutants decreased the time for worms to initiate reversal avoidance to octanol.	Octanols	155-162	Acetylcholine-gated chloride channel subunit acc-1	Caenorhabditis elegans	27-32
30401619-9	2018	Overexpression of both cel-acc-1 and hco-acc-1 in both C. elegans N2 and acc-1 null mutants decreased the time for worms to initiate reversal avoidance to octanol.	Octanols	155-162	Acetylcholine-gated chloride channel subunit acc-1	Caenorhabditis elegans	41-46
28212986-6	2017	The extent of conformational destabilization and protein aggregation of mAb-4 induced by APs followed their calculated octanol-water partition coefficients.	Octanols	119-126	immunoglobulin kappa variable 4-62	Mus musculus	72-77
29281280-0	2018	Extraction of Gd3+ and UO22+ Ions Using Polystyrene Grafted Dibenzo Crown Ether (DB18C6) with Octanol and Nitrobenzene: A Molecular Dynamics Study.	Octanols	94-101	GRDX	Homo sapiens	14-17
29312496-8	2017	The phosphorylation of Akt was enhanced by cerebral I/R and octanol but inhibited by ZP123.	Octanols	60-67	AKT serine/threonine kinase 1	Rattus norvegicus	23-26
28592157-6	2017	Protein tyrosine phosphatase 1B inhibitors with calculated log octanol >3.0 were the most toxic.	Octanols	63-70	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	0-31
24676712-5	2014	Consistently, octanol attenuated the number of transferase dUTP nick-end labeling (TUNEL) positive neurons in the hippocampal CA1 region following 2 h of occlusion, while opposite effects were observed for 30 min of occlusion.	Octanols	14-21	carbonic anhydrase 1	Rattus norvegicus	126-129
27977141-9	2017	This is a significant advancement in understanding the global transport process and the pathways entering the Arctic for chemicals with low volatility and high octanol-air partition coefficients, such as BDE-209.	Octanols	160-167	homeobox D13	Homo sapiens	204-207
26044641-6	2015	The oxaliplatin effect and neuroprotection by octanol partially persisted in Cx29 better than in Cx32 KO nerves, suggesting that oxaliplatin affects both, but Cx32 GJ channels more than Cx29 hemichannels.	Octanols	46-53	gap junction protein gamma 3	Homo sapiens	77-81
26044641-6	2015	The oxaliplatin effect and neuroprotection by octanol partially persisted in Cx29 better than in Cx32 KO nerves, suggesting that oxaliplatin affects both, but Cx32 GJ channels more than Cx29 hemichannels.	Octanols	46-53	gap junction protein beta 1	Homo sapiens	97-101
26044641-7	2015	Oxaliplatin also accelerated neurobiotin uptake in HeLa cells expressing the human ortholog of Cx29, Cx31.3, as well as dye transfer between cells expressing the human Cx32, and this effect was blocked by octanol.	Octanols	205-212	gap junction protein gamma 3	Homo sapiens	95-99
26044641-7	2015	Oxaliplatin also accelerated neurobiotin uptake in HeLa cells expressing the human ortholog of Cx29, Cx31.3, as well as dye transfer between cells expressing the human Cx32, and this effect was blocked by octanol.	Octanols	205-212	gap junction protein gamma 3	Homo sapiens	101-107
26044641-7	2015	Oxaliplatin also accelerated neurobiotin uptake in HeLa cells expressing the human ortholog of Cx29, Cx31.3, as well as dye transfer between cells expressing the human Cx32, and this effect was blocked by octanol.	Octanols	205-212	gap junction protein beta 1	Homo sapiens	168-172
25089710-3	2014	cat-2 mutant animals that are deficient in dopamine biosynthesis have an increased response latency to octanol compared to wild type animals, and this defect can be fully restored with the application of exogenous dopamine.	Octanols	103-110	BH4_AAA_HYDROXYL_2 domain-containing protein;Tyrosine 3-hydroxylase;Tyrosine 3-monooxygenase	Caenorhabditis elegans	0-5
25089710-5	2014	cat-2 mutant animals lacking either the GLR-1 or GLR-2 AMPA/kainate receptors displayed an increased response latency to octanol, which could be restored via exogenous dopamine.	Octanols	121-128	BH4_AAA_HYDROXYL_2 domain-containing protein;Tyrosine 3-hydroxylase;Tyrosine 3-monooxygenase	Caenorhabditis elegans	0-5
25089710-5	2014	cat-2 mutant animals lacking either the GLR-1 or GLR-2 AMPA/kainate receptors displayed an increased response latency to octanol, which could be restored via exogenous dopamine.	Octanols	121-128	Glutamate receptor 1	Caenorhabditis elegans	40-45
25089710-5	2014	cat-2 mutant animals lacking either the GLR-1 or GLR-2 AMPA/kainate receptors displayed an increased response latency to octanol, which could be restored via exogenous dopamine.	Octanols	121-128	Glutamate receptor 2	Caenorhabditis elegans	49-54
25089710-6	2014	However, whereas cat-2 mutant animals lacking the NMR-1 NMDA receptor had increased response latency to octanol they were insensitive to exogenous dopamine.	Octanols	104-111	BH4_AAA_HYDROXYL_2 domain-containing protein;Tyrosine 3-hydroxylase;Tyrosine 3-monooxygenase	Caenorhabditis elegans	17-22
25089710-6	2014	However, whereas cat-2 mutant animals lacking the NMR-1 NMDA receptor had increased response latency to octanol they were insensitive to exogenous dopamine.	Octanols	104-111	LITAF domain-containing protein	Caenorhabditis elegans	50-55
25089710-8	2014	Our results indicate that dopamine modulation of octanol avoidance requires NMR-1, consistent with NMR-1 as a potential downstream signaling target for dopamine.	Octanols	49-56	LITAF domain-containing protein	Caenorhabditis elegans	76-81
27294337-3	2016	The chloro ligand hydrolysis slowly and the octanol and water partition coefficient of Ru2-Ru4 were between 0.6 and 1.2.	Octanols	44-51	doublecortin domain containing 2	Homo sapiens	87-90
26428356-9	2015	The optimal log D7.4 (octanol/water distribution coefficient at pH 7.4) value for inhibition of CYP2E1 was approximately 2.4.	Octanols	22-29	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	96-102
26210018-4	2015	The GC-RT was used in this work with the aim of determining the vapor pressure, enthalpies of vaporization and octanol-air partition coefficient, for the BBP, DOP, E- and Z-EHMC esters.	Octanols	111-118	transmembrane protein 158	Homo sapiens	154-157
25901942-0	2015	Confocal Raman Microscopy for in Situ Measurement of Octanol-Water Partitioning within the Pores of Individual C18-Functionalized Chromatographic Particles.	Octanols	53-60	Bardet-Biedl syndrome 9	Homo sapiens	111-114
25901942-6	2015	In this work, we reduce the receiver volume of octanol-water partitioning measurements from current practice by six-orders-of-magnitude, to the femtoliter scale, by using a single octanol-filled reversed-phase, octadecylsilane-modified (C18-silica) chromatographic particle as a collector.	Octanols	47-54	Bardet-Biedl syndrome 9	Homo sapiens	237-240
25901942-6	2015	In this work, we reduce the receiver volume of octanol-water partitioning measurements from current practice by six-orders-of-magnitude, to the femtoliter scale, by using a single octanol-filled reversed-phase, octadecylsilane-modified (C18-silica) chromatographic particle as a collector.	Octanols	180-187	Bardet-Biedl syndrome 9	Homo sapiens	237-240
25582782-7	2015	The empirical relationships between the organic-carbon normalized sorption coefficient (Koc) and water solubility and between Koc and the octanol-water partition coefficient (Kow) were established.	Octanols	138-145	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	126-129
24753074-6	2014	Gap junction blockade by two distinct GJIC inhibitors, 18alpha-glycyrrhetinic acid (AGA) and octanol (OcOH), suppressed proliferation and induced apoptosis in endometrial stromal cells, as manifested by reduced biomarkers of cell viability, increased TUNEL staining, caspase-3 activation, sub-G1 chromosomal DNA complement, as well as shortened telomere length.	Octanols	93-100	caspase 3	Homo sapiens	267-276
24676712-6	2014	Further immunohistochemical studies demonstrated that the expression of B-cell leukemia-2 (Bcl-2, anti-apoptotic protein) was upregulated and that Bcl-2-associated X (Bax, proapoptotic protein) was downregulated following 2 h of occlusion in the octanol group compared with the ischemic group.	Octanols	246-253	BCL2, apoptosis regulator	Rattus norvegicus	72-89
24676712-6	2014	Further immunohistochemical studies demonstrated that the expression of B-cell leukemia-2 (Bcl-2, anti-apoptotic protein) was upregulated and that Bcl-2-associated X (Bax, proapoptotic protein) was downregulated following 2 h of occlusion in the octanol group compared with the ischemic group.	Octanols	246-253	BCL2, apoptosis regulator	Rattus norvegicus	91-96
24676712-6	2014	Further immunohistochemical studies demonstrated that the expression of B-cell leukemia-2 (Bcl-2, anti-apoptotic protein) was upregulated and that Bcl-2-associated X (Bax, proapoptotic protein) was downregulated following 2 h of occlusion in the octanol group compared with the ischemic group.	Octanols	246-253	BCL2 associated X, apoptosis regulator	Rattus norvegicus	147-165
24676712-7	2014	Conversely, octanol downregulated the expression of the Bcl-2 protein concomitant with increased Bax protein following 30 min of occlusion.	Octanols	12-19	BCL2, apoptosis regulator	Rattus norvegicus	56-61
24676712-7	2014	Conversely, octanol downregulated the expression of the Bcl-2 protein concomitant with increased Bax protein following 30 min of occlusion.	Octanols	12-19	BCL2 associated X, apoptosis regulator	Rattus norvegicus	97-100
24865489-5	2014	In this article, we evaluated the PBT properties of compounds reported to possess anti-fouling properties using QSAR (quantitative structure-activity relationship) prediction programs such as BIOWIN  (a biodegradation probability program), KOWWIN  (log octanol-water partition coefficient calculation program) and ECOSAR  (Ecological Structure Activity Relationship Programme).	Octanols	253-260	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	34-37
23870498-5	2014	This is consistent with the high consumption of deca-BDE in Korea and the very high octanol-water partition coefficient of deca-BDE.	Octanols	84-91	homeobox D13	Homo sapiens	128-131
24644297-2	2014	The passive permeability across the blood-brain barrier (BBB), PS1, was predicted by two methods using log(D/molecular weight(0.5)) for PS1(1) or the partition coefficient in octanol/water at pH 7.4 (LogD), topologic van der Waals polar surface area, and van der Waals surface area of the basic atoms for PS1(2).	Octanols	175-182	presenilin 1	Rattus norvegicus	63-66
25756669-6	2014	We establish that the physicochemical parameters critical for DPP4 inhibitory activity are: hydrophobicity described by the logarithm of the octanol/water partition coefficient, counts of rotatable bonds, hydrogen bond donor and acceptor atoms, and topological polar surface area.	Octanols	141-148	dipeptidyl peptidase 4	Homo sapiens	62-66
23692447-2	2013	Ethanol, butanol, and octanol quenched the intrinsic fluorescence of the C1 domain of Munc13-1 with EC50 s of 52 mM, 26 mM, and 0.7 mM, respectively.	Octanols	22-29	unc-13 homolog A	Rattus norvegicus	86-94
23454167-8	2013	Finally, pharmacological blockade of connexin hemichannels with 18beta-glycyrrhetinic acid, octanol and carbenoxolone inhibited the NAD(+)-mediated cell rescue of PARP-triggered cell death.	Octanols	92-99	poly(ADP-ribose) polymerase 1	Homo sapiens	163-167
23141842-8	2013	The bioavailable fraction of PAH was inversely correlated to the number of benzene rings and the octanol-water partition coefficient.	Octanols	97-104	phenylalanine hydroxylase	Homo sapiens	29-32
23407022-6	2013	Inhibition of intercellular communication using carbenoxolone or octanol fully blocked the propagation of ACh-induced Ca(2+) transients toward adjacent cells in WT and Cx40-/- mice.	Octanols	65-72	gap junction protein, alpha 5	Mus musculus	168-172
23192000-7	2012	In addition, 1,8-cineole inhibited human TRPA1 currents activated by allyl isothiocyanate, menthol, fulfenamic acid or octanol in a dose-dependent manner.	Octanols	119-126	transient receptor potential cation channel subfamily A member 1	Homo sapiens	41-46
23192000-8	2012	Furthermore, in vivo sensory irritation tests showed that 1,8-cineole conferred an analgesic effect on sensory irritation produced by TRPA1 agonists octanol and menthol.	Octanols	149-156	transient receptor potential cation channel subfamily A member 1	Homo sapiens	134-139
23076175-8	2012	CONCLUSION: Connexin 43-formed hemichannels are involved in the regulation of cardiomyocyte volumes induced by SI/R challenge, and octanol can alleviate the cell swelling to enhance the viability of the cardiomyocytes following SI/R.	Octanols	131-138	gap junction protein, alpha 1	Mus musculus	12-23
21832186-5	2011	We analyzed one C. elegans food-regulated behavior in depth; AGS-3 activates Galpha(o) in the ASH chemosensory neurons to allow food-deprived animals to delay response to the aversive stimulus octanol.	Octanols	193-200	Activator of G protein signaling	Caenorhabditis elegans	61-66
22222967-9	2012	Furthermore, straight-chain secondary alcohols increased intracellular Ca(2+) concentrations in HEK293 cells expressing hTRPA1, and both primary and secondary alcohols showed hTRPA1 activation activities that correlated highly with their octanol/water partition coefficients.	Octanols	238-245	transient receptor potential cation channel subfamily A member 1	Homo sapiens	175-181
24353899-5	2011	n-alkanols (ethanol, butanol, pentanol, hexanol, heptanol, octanol and nonanol) showed differential effects on guanine nucleotide exchange by Galphai1, Galphai2 and Galphao.	Octanols	59-66	G protein subunit alpha o1	Homo sapiens	165-172
21606109-6	2011	In cells expressing Cx45, IC50 for octanol was 0.1, 0.25 and 2.68 mm at pH(i) values of 6.9, 7.2 and 8.1, respectively.	Octanols	35-42	gap junction protein gamma 1	Homo sapiens	20-24
21606109-7	2011	Histidine modification of Cx45 protein by N-bromosuccinimide reduced the coupling-promoting effect of NH4Cl as well as the uncoupling effect of octanol.	Octanols	144-151	gap junction protein gamma 1	Homo sapiens	26-30
21832186-6	2011	Genetic epistasis experiments show the following: (1) AGS-3 and the guanine nucleotide exchange factor RIC-8 act in ASH in a mutually dependent fashion to activate Galpha(o); (2) this activation requires interaction of the GPR domains of AGS-3 with Galpha(o); and (3) Galpha(o)-GTP is ultimately the signaling molecule that acts in ASH to delay octanol response.	Octanols	345-352	Activator of G protein signaling	Caenorhabditis elegans	54-59
21832186-6	2011	Genetic epistasis experiments show the following: (1) AGS-3 and the guanine nucleotide exchange factor RIC-8 act in ASH in a mutually dependent fashion to activate Galpha(o); (2) this activation requires interaction of the GPR domains of AGS-3 with Galpha(o); and (3) Galpha(o)-GTP is ultimately the signaling molecule that acts in ASH to delay octanol response.	Octanols	345-352	Synembryn	Caenorhabditis elegans	103-108
21708071-8	2011	The distance of GFAP immunoreactive astrocytes from the wound margin was decreased by 32 and 18% when octanol was administrated prior to or post injury respectively.	Octanols	102-109	glial fibrillary acidic protein	Rattus norvegicus	16-20
21708071-9	2011	Treatment with octanol also decreased the number of reactive microglia by 55% and, when administrated prior to injury, octanol reduced the distance of NG2 expression from the wound by 48%.	Octanols	119-126	chondroitin sulfate proteoglycan 4	Rattus norvegicus	151-154
20601149-9	2010	Using that platform, we designed and validated a peptidomimetic compound (ZP2519; molecular weight 619 Da) that prevented octanol-induced uncoupling of Cx43 channels and pH gating of cardiac gap junctions.	Octanols	122-129	gap junction protein alpha 1	Homo sapiens	152-156
21549604-2	2011	We report here that Notch ligands, coligands, and the receptors LIN-12 and GLP-1 regulate two C. elegans behaviors: chemosensory avoidance of octanol and quiescence during molting lethargus.	Octanols	142-149	lin-12/Notch intracellular domain	Caenorhabditis elegans	20-25
21549604-2	2011	We report here that Notch ligands, coligands, and the receptors LIN-12 and GLP-1 regulate two C. elegans behaviors: chemosensory avoidance of octanol and quiescence during molting lethargus.	Octanols	142-149	lin-12/Notch intracellular domain	Caenorhabditis elegans	64-70
21549604-2	2011	We report here that Notch ligands, coligands, and the receptors LIN-12 and GLP-1 regulate two C. elegans behaviors: chemosensory avoidance of octanol and quiescence during molting lethargus.	Octanols	142-149	glp-1/Notch intracellular domain	Caenorhabditis elegans	75-80
21549604-3	2011	RESULTS: C. elegans lacking osm-7 or osm-11 are defective in their response to octanol.	Octanols	79-86	Uncharacterized protein	Caenorhabditis elegans	28-33
21549604-3	2011	RESULTS: C. elegans lacking osm-7 or osm-11 are defective in their response to octanol.	Octanols	79-86	Notch ligand osm-11	Caenorhabditis elegans	37-43
21549604-5	2011	OSM-11 acts with the DSL ligand LAG-2 to activate LIN-12 and GLP-1 Notch receptors in the neurons of adult animals, thereby regulating octanol avoidance response.	Octanols	135-142	Notch ligand osm-11	Caenorhabditis elegans	0-6
21549604-5	2011	OSM-11 acts with the DSL ligand LAG-2 to activate LIN-12 and GLP-1 Notch receptors in the neurons of adult animals, thereby regulating octanol avoidance response.	Octanols	135-142	Protein lag-2	Caenorhabditis elegans	32-37
21549604-5	2011	OSM-11 acts with the DSL ligand LAG-2 to activate LIN-12 and GLP-1 Notch receptors in the neurons of adult animals, thereby regulating octanol avoidance response.	Octanols	135-142	lin-12/Notch intracellular domain	Caenorhabditis elegans	50-56
21549604-5	2011	OSM-11 acts with the DSL ligand LAG-2 to activate LIN-12 and GLP-1 Notch receptors in the neurons of adult animals, thereby regulating octanol avoidance response.	Octanols	135-142	glp-1/Notch intracellular domain	Caenorhabditis elegans	61-66
21549604-5	2011	OSM-11 acts with the DSL ligand LAG-2 to activate LIN-12 and GLP-1 Notch receptors in the neurons of adult animals, thereby regulating octanol avoidance response.	Octanols	135-142	lin-12/Notch intracellular domain	Caenorhabditis elegans	67-72
20153476-1	2010	A rapid throughput octanol-water lipophilicity measurement based on 96-well shake-flask and LC/UV/APPI/MS is described.	Octanols	19-26	amyloid beta precursor protein	Homo sapiens	98-102
20821618-9	2010	For example, the interaction of PFOA with L-FABP is almost identical to that of the acidic ionizing drugs ketolac, ibuprofen, and warfarin that show specificity to protein partitioning with a magnitude that is proportional to the K(OW) (octanol-water partitioning) of the neutral species.	Octanols	237-244	fatty acid binding protein 1	Rattus norvegicus	42-48
20363234-4	2010	Octanol, 1-heptanol (heptanol) and 1-hexanol (hexanol) inhibited the recombinant Ca(V)3.1 currents in concentration-dependent manner yielding IC(50) values of 362 microM, 1063 microM and 3167 microM, respectively.	Octanols	0-7	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	81-89
20363234-5	2010	Octanol similarly inhibited native thalamic Ca(V)3.1 T-currents with an IC(50) of 287 microM and diminished burst firing without significant effect on passive membrane properties of these neurons.	Octanols	0-7	caveolin 3	Homo sapiens	44-50
20106679-4	2010	Consideration of octanol/water partition coefficients (K(ow)) of the 43 analytes in the light of their DESI results reveals the importance of the solubility of analyte in the spray solvent in producing high quality mass spectra.	Octanols	17-24	desumoylating isopeptidase 2	Homo sapiens	103-107
20209143-2	2010	C. elegans lacking the CAT-2 tyrosine hydroxylase enzyme, which is required for dopamine biosynthesis, are hypersensitive in their behavioral avoidance of dilute concentrations of octanol.	Octanols	180-187	BH4_AAA_HYDROXYL_2 domain-containing protein;Tyrosine 3-hydroxylase;Tyrosine 3-monooxygenase	Caenorhabditis elegans	23-28
20209143-4	2010	rgs-3 mutant animals are defective in their avoidance of 100% octanol when they are assayed in the absence of food (E. coli bacterial lawn), but their response is restored when they are assayed in the presence of food or exogenous dopamine.	Octanols	62-69	Regulator of G-protein signaling rgs-3	Caenorhabditis elegans	0-5
20209143-7	2010	We show that DOP-3 is required for the ability of food and exogenous dopamine to rescue the octanol avoidance defect of rgs-3 mutant animals.	Octanols	92-99	Dopamine receptor 3	Caenorhabditis elegans	13-18
20209143-7	2010	We show that DOP-3 is required for the ability of food and exogenous dopamine to rescue the octanol avoidance defect of rgs-3 mutant animals.	Octanols	92-99	Regulator of G-protein signaling rgs-3	Caenorhabditis elegans	120-125
20209143-8	2010	In addition, otherwise wild-type animals lacking DOP-3 function are hypersensitive to dilute octanol, reminiscent of cat-2 mutants.	Octanols	93-100	Dopamine receptor 3	Caenorhabditis elegans	49-54
20209143-9	2010	Furthermore, we demonstrate that DOP-3 function in the ASH sensory neurons is sufficient to rescue the hypersensitivity of dop-3 mutant animals, while dop-3 RNAi knockdown in ASH results in octanol hypersensitivity.	Octanols	190-197	Dopamine receptor 3	Caenorhabditis elegans	151-156
20209143-10	2010	Taken together, our data suggest that dopaminergic signaling through DOP-3 normally acts to dampen ASH signaling and behavioral sensitivity to octanol.	Octanols	143-150	Dopamine receptor 3	Caenorhabditis elegans	69-74
19432558-5	2009	Ethanol, butanol and octanol increased the binding affinity of a fluorescent phorbol ester SAPD (sapintoxin-D) to PKC epsilon C1B in a concentration-dependent manner with EC50 values of 78 mM, 8 mM and 340 microM respectively, suggesting the presence of an allosteric alcohol-binding site in this subdomain.	Octanols	21-28	protein kinase C, epsilon	Mus musculus	114-125
19652506-3	2009	By observing relationship between the compounds" physicochemical properties and APPI response, compounds with higher lipophilicity and less polar surface area were considered to be advantageous for APPI-MS. To provide information for applying APPI-MS to the analysis of hydrophilic drugs, approximate lower limit of calculated octanol-water partition coefficient and the higher limit of the number of oxygen and nitrogen atoms were determined to be -0.95 and 6, respectively.	Octanols	327-334	amyloid beta precursor protein	Homo sapiens	80-84
19652506-3	2009	By observing relationship between the compounds" physicochemical properties and APPI response, compounds with higher lipophilicity and less polar surface area were considered to be advantageous for APPI-MS. To provide information for applying APPI-MS to the analysis of hydrophilic drugs, approximate lower limit of calculated octanol-water partition coefficient and the higher limit of the number of oxygen and nitrogen atoms were determined to be -0.95 and 6, respectively.	Octanols	327-334	amyloid beta precursor protein	Homo sapiens	198-202
19652506-3	2009	By observing relationship between the compounds" physicochemical properties and APPI response, compounds with higher lipophilicity and less polar surface area were considered to be advantageous for APPI-MS. To provide information for applying APPI-MS to the analysis of hydrophilic drugs, approximate lower limit of calculated octanol-water partition coefficient and the higher limit of the number of oxygen and nitrogen atoms were determined to be -0.95 and 6, respectively.	Octanols	327-334	amyloid beta precursor protein	Homo sapiens	198-202
20060312-3	2010	The more lipophilic nature of triphenylphosphonium ion over triethylammonium ion renders P1 and P2 higher octanol/water partition coefficients than P3 and P4.	Octanols	106-113	crystallin gamma F, pseudogene	Homo sapiens	89-98
19893262-8	2009	The rCBF value obtained by the input function, the factor of which is a time-dependent brain count of 5 minutes from administration, and the objective variable is artery octanol value, had a high correlation with the MS method (y=0.899x+4.653, r=0.842).	Octanols	170-177	CCAAT/enhancer binding protein zeta	Rattus norvegicus	4-8
19275147-3	2009	Multivariate calibration was used to derive a quantitative relationship between the measured relative response factor (RRF) of polar metabolites with respect to four physicochemical properties associated with ion evaporation in ESI-MS, namely, molecular volume (MV), octanol-water distribution coefficient (log D), absolute mobility (mu(o)), and effective charge (z(eff)).	Octanols	267-274	mitochondrial ribosome recycling factor	Homo sapiens	119-122
19375083-2	2009	The values of log K(doc) determined with equilibrium SPME were linearly correlated with the logarithm of the octanol-water partition coefficients (K(ow)) for PCB congeners at logK(ow)< approximately 7.2, but the trends were disrupted for logK(ow) from approximately 7.2 to 8.18.	Octanols	109-116	pyruvate carboxylase	Homo sapiens	158-161
19601870-4	2009	The analysis of P450-catalyzed reaction rates is elaborated to encompass a treatment of metabolic clearance, and satisfactory correlations are obtained with literature values for both intrinsic clearance and whole body clearance in terms of compound lipophilicity derived from log P data, where P is the octanol/water partition coefficient.	Octanols	304-311	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	16-20
19452923-4	2009	The dietary absorption efficiency decreased with increasing octanol-water partition coefficient of the BDE congener.	Octanols	60-67	homeobox D13	Homo sapiens	103-106
19193891-5	2009	Because none of these 5-HT receptors appear to be expressed in the ASH sensory neurons mediating octanol sensitivity, we identified a 5-HT(6)-like receptor, F16D3.7(SER-5), that was required for food/5-HT-dependent increases in octanol sensitivity.	Octanols	97-104	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	165-170
19193891-5	2009	Because none of these 5-HT receptors appear to be expressed in the ASH sensory neurons mediating octanol sensitivity, we identified a 5-HT(6)-like receptor, F16D3.7(SER-5), that was required for food/5-HT-dependent increases in octanol sensitivity.	Octanols	228-235	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	165-170
19193891-7	2009	Similarly, the RNAi knockdown of ser-5 expression in the ASHs of wild-type animals also abolished 5-HT-dependent increases in octanol sensitivity, suggesting that SER-5 modulates the octanol responsiveness of the ASHs directly.	Octanols	126-133	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	33-38
19193891-7	2009	Similarly, the RNAi knockdown of ser-5 expression in the ASHs of wild-type animals also abolished 5-HT-dependent increases in octanol sensitivity, suggesting that SER-5 modulates the octanol responsiveness of the ASHs directly.	Octanols	183-190	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	33-38
19193891-7	2009	Similarly, the RNAi knockdown of ser-5 expression in the ASHs of wild-type animals also abolished 5-HT-dependent increases in octanol sensitivity, suggesting that SER-5 modulates the octanol responsiveness of the ASHs directly.	Octanols	183-190	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	163-168
18984566-4	2008	This delayed avoidance is due to an increased attraction rather than a decreased avoidance to benzaldehyde because (1) aged odr-3 mutants that are defective in odor attraction showed no delayed benzaldehyde avoidance, and (2) the delay in avoidance was also observed with another attractant diacetyl, but not the repellent octanol.	Octanols	323-330	Guanine nucleotide-binding protein alpha-17 subunit	Caenorhabditis elegans	124-129
20408502-3	2009	Both substrate binding to CYP2F2 and metabolic clearance by CYP2F enzymes correlate with the lipophilicity, parameter, log P (where P is the octanol/water partition coefficient of the substrate).	Octanols	141-148	cytochrome P450, family 2, subfamily f, polypeptide 2	Mus musculus	26-32
20408502-3	2009	Both substrate binding to CYP2F2 and metabolic clearance by CYP2F enzymes correlate with the lipophilicity, parameter, log P (where P is the octanol/water partition coefficient of the substrate).	Octanols	141-148	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	26-31
17945372-2	2008	A detailed study of the effects of solvent choice and substrate concentrations on the acrylation of octanol by Candida antarctica lipase B (Novozym 435) is presented.	Octanols	100-107	PAN0_003d1715	Moesziomyces antarcticus	130-136
17226782-9	2007	However, after treatment with keratinocyte-conditioned medium or cytokine mixtures containing at least TNF-alpha and IL-1beta, they became transiently coupled through a pathway sensitive to octanol, a gap junction blocker.	Octanols	190-197	tumor necrosis factor	Mus musculus	103-112
17595315-9	2007	Similar effects were obtained at low/high (5.5/8.5) pH, but using octanol to limit the flux of electrons from POR to CYP19A1 inhibited activity supported by all variants.	Octanols	66-73	cytochrome p450 oxidoreductase	Homo sapiens	110-113
17595315-9	2007	Similar effects were obtained at low/high (5.5/8.5) pH, but using octanol to limit the flux of electrons from POR to CYP19A1 inhibited activity supported by all variants.	Octanols	66-73	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	117-124
17727915-2	2007	Concentrations of substances in these livestock products are often estimated using log-log regressions that relate the biotransfer factor BTF to the octanol-water partition ratio K(ow).	Octanols	149-156	BCL2 associated transcription factor 1	Homo sapiens	138-141
17226782-9	2007	However, after treatment with keratinocyte-conditioned medium or cytokine mixtures containing at least TNF-alpha and IL-1beta, they became transiently coupled through a pathway sensitive to octanol, a gap junction blocker.	Octanols	190-197	interleukin 1 beta	Mus musculus	117-125
16884298-4	2006	According to the d parameter, good correlations should be obtained between chromatographic systems (both IAM and C18) and octanol-water partition coefficient (log P), and thus both types of columns could be used to obtain log P values.	Octanols	122-129	Bardet-Biedl syndrome 9	Homo sapiens	113-116
17633179-5	2007	Significant positive correlations between partition coefficients (Koc), which was defined as the ratio of PAH isomers concentrations in surface sediment to those in seawater, and their octanol/water partition coefficients (Kow) were observed, i. e., the sorption constant Koc of PAHs in the bay may be predictd by the Kow for the compounds analyzed.	Octanols	185-192	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	66-69
16943444-4	2006	Octanol and butanol both quenched the intrinsic fluorescence of PKCdelta C1A in a saturable manner, suggesting the presence of a binding site.	Octanols	0-7	protein kinase C, delta	Mus musculus	64-72
19127741-6	2006	With the increase of IgK(ow) (octanol-water partition coefficient) of the PAHs, both root concentration factors and leaf concentration factors increased exponentially, while translocation factors from roots to leaves decreased exponentially.	Octanols	30-37	immunoglobulin kappa locus	Homo sapiens	21-24
16789425-4	2006	This is evidenced by linear correlations between inhibition of CYP3A4 and the octanol-water partition coefficient (P value) when expressed logarithmically (ie., log P).	Octanols	78-85	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	63-69
15961560-6	2005	The TGFbeta3-neutralizing antibody and the gap junction inhibitor octanol reduced the effect of TGFbeta3 on the transfer of dye.	Octanols	66-73	transforming growth factor beta 3	Homo sapiens	96-104
16154329-3	2005	2D-QSAR modeling using simulated annealing partial least squares (SA-PLS) method identified octanol/water partition coefficient, hydrophobicity, and negative charge as three important factors for MTX and MTX analogue affinity to rMrp2.	Octanols	92-99	ATP binding cassette subfamily C member 2	Rattus norvegicus	229-234
15961560-11	2005	The gap-junction inhibitor octanol reduced TGFbeta3-increased levels of bFGF in FS cells.	Octanols	27-34	fibroblast growth factor 2	Homo sapiens	72-76
15961560-11	2005	The gap-junction inhibitor octanol reduced TGFbeta3-increased levels of bFGF in FS cells.	Octanols	27-34	transforming growth factor beta 3	Homo sapiens	43-51
15713013-1	2005	The ability of immobilized lipase Candida antarctica (Novozyme 435) to catalyze the direct esterification of hydroxyphenylpropionic acid and octanol in a solvent-free system was investigated in this study.	Octanols	141-148	PAN0_003d1715	Moesziomyces antarcticus	27-33
15794568-15	2005	The present study also obtained a bell-shaped relationship between log Kf and log Kow (octanol-water partition coefficient) for PCB congeners with the maximum log Kf corresponding to log Kow approximately 6.5.	Octanols	87-94	pyruvate carboxylase	Homo sapiens	128-131
13129833-6	2003	n-Alcohols (ethanol through octanol) were applied to alpha2(L262A)beta4 nAChRs.	Octanols	28-35	MGC75582, possible similarity to act2 S homeolog	Xenopus laevis	53-59
15150578-6	2004	[(18)F]FETA, with an octanol-water partition coefficient of 0.16+/-0.01, was selectively retained by RIF-1 cells under hypoxia compared to air (3.4- to 4.3-fold at 60-120 min).	Octanols	21-28	ATPase, class I, type 8B, member 5	Mus musculus	7-11
15150578-6	2004	[(18)F]FETA, with an octanol-water partition coefficient of 0.16+/-0.01, was selectively retained by RIF-1 cells under hypoxia compared to air (3.4- to 4.3-fold at 60-120 min).	Octanols	21-28	replication timing regulatory factor 1	Mus musculus	101-106
14967738-12	2004	Octanol stimulated (125)I efflux in a dose-dependent manner in CFTR-expressing cells (wild-type and delF508) but not in cell lines lacking CFTR.	Octanols	0-7	CF transmembrane conductance regulator	Homo sapiens	63-67
14967738-13	2004	(125)I efflux and Cl(-) currents induced by octanol were blocked by glibenclamide but insensitive to 4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid, as expected for a CFTR Cl(-) current.	Octanols	44-51	CF transmembrane conductance regulator	Homo sapiens	171-175
14967738-15	2004	CFTR activation by octanol was neither due to cell-to-cell uncoupling properties of octanol nor to an intracellular cAMP increase.	Octanols	19-26	CF transmembrane conductance regulator	Homo sapiens	0-4
14967738-15	2004	CFTR activation by octanol was neither due to cell-to-cell uncoupling properties of octanol nor to an intracellular cAMP increase.	Octanols	84-91	CF transmembrane conductance regulator	Homo sapiens	0-4
14967738-16	2004	CFTR activation by octanol requires phosphorylation by protein kinase-A (PKA) since it was prevented by H-89, a PKA inhibitor.	Octanols	19-26	CF transmembrane conductance regulator	Homo sapiens	0-4
14500778-7	2003	The same modifications on ACh responses were obtained with ethanol on alpha2(L263C)beta4 and octanol on alpha2(L262C)beta4.	Octanols	93-100	MGC75582, possible similarity to act2 S homeolog	Xenopus laevis	104-110
14500778-7	2003	The same modifications on ACh responses were obtained with ethanol on alpha2(L263C)beta4 and octanol on alpha2(L262C)beta4.	Octanols	93-100	basic helix-loop-helix family member e23 L homeolog	Xenopus laevis	117-122
14637340-4	2004	Aspen wood-water sorption coefficients, Kww, were linearly correlated to octanol-water partition coefficients and the molecular weight of the studied PAH compounds.	Octanols	73-80	phenylalanine hydroxylase	Homo sapiens	150-153
14753679-6	2004	The aqueous solubility of CL-20 was poor (3.6 mg l(-1) at 25 degrees C) and increased with temperature to reach 18.5 mg l(-1) at 60 degrees C. The octanol-water partition coefficient of CL-20 (log KOW = 1.92) was higher than that of RDX (log KOW = 0.90) and HMX (log KOW = 0.16), indicating its higher affinity to organic matter.	Octanols	147-154	epithelial membrane protein 1	Homo sapiens	26-31
12924577-4	2003	In turn, KOC values have been estimated by quantitative structure-activity relationships (QSARs) developed by correlation with a variety of physical or chemical properties and structural descriptors related to the hydrophobicity of the chemical such as octanol-water partition coefficients, aqueous solubilities, molecularconnectivity indices, molecular weight, molecular surface area, and reverse-phase high-performance liquid chromatography retention times.	Octanols	253-260	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	9-12
14570646-9	2003	The dissociation of octanol was too quick to be distinguished from normal current repriming kinetics of 2.2 ms. Lidocaine and octanol acted noncompetitively in the Na(+) channel.	Octanols	20-27	sodium voltage-gated channel alpha subunit 8	Rattus norvegicus	164-177
14570646-9	2003	The dissociation of octanol was too quick to be distinguished from normal current repriming kinetics of 2.2 ms. Lidocaine and octanol acted noncompetitively in the Na(+) channel.	Octanols	126-133	sodium voltage-gated channel alpha subunit 8	Rattus norvegicus	164-177
12927115-5	2003	The lower the E(LUMO), the greater the intermolecular interactions between octanol and PCB molecules, and thus the greater the logK(OA) values.	Octanols	75-82	pyruvate carboxylase	Homo sapiens	87-90
12615112-7	2003	The lower the E(LUMO) (the energy of the lowest unoccupied molecular orbital), the greater the intermolecular interactions between octanol and PCB molecules, and thus the greater the logK(OA) values.	Octanols	131-138	pyruvate carboxylase	Homo sapiens	143-146
12854704-6	2003	The octanol-air partition coefficient (K(OA)) derived model provides a good description of PAH soil-air partitioning coefficients (K(P)) below the inversion layer but underpredicts them in the area dominated by deposition of long-range transported aerosols without inputs of organic matter from local vegetation.	Octanols	4-11	phenylalanine hydroxylase	Homo sapiens	91-94
12543383-2	2003	This acylation method gave rise to a different enzyme entity (Ac-SOD) as evidenced by different physicochemical properties such as octanol/water partition coefficient and isoelectric point (pI) as compared to SOD.	Octanols	131-138	superoxide dismutase 1	Homo sapiens	65-68
11077069-8	2001	Both the degree of 5-HT(1A) receptor activation by 8-OH-DPAT and (-)-pindolol, and its inhibition by spiperone, strongly correlate (r(2): 0.78-0.81) with the octanol/water partition coefficients of the mutated amino acid at position 351 of the G(alphai3) protein.	Octanols	158-165	5-hydroxytryptamine receptor 1A	Homo sapiens	19-36
12521113-8	2003	The organic carbon normalised distribution coefficient (K(oc)) also increased with the compounds" octanol/water partition coefficient (K(ow)), confirming the potential applicability of the linear free energy relationships in the modelling and prediction of PAH behaviour in marine environments.	Octanols	98-105	phenylalanine hydroxylase	Homo sapiens	257-260
11997239-4	2002	IL-1beta produced a dose-dependent increase in MMP activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min.	Octanols	152-159	interleukin 1 beta	Homo sapiens	0-8
11734643-6	2001	This effect was significantly eliminated in cells pretreated with a 1 mM dose of octanol, which inhibits gap junction-mediated intercellular communication, or in cells carrying a dominant negative connexin 43 vector.	Octanols	81-88	gap junction protein alpha 1	Homo sapiens	197-208
11472245-0	2001	Rapid method for the estimation of octanol/water partition coefficient (log P(oct)) from gradient RP-HPLC retention and a hydrogen bond acidity term (zetaalpha(2)(H)).	Octanols	35-42	plexin A2	Homo sapiens	72-82
11280710-9	2001	The low lipophilicity of ADM determined by the octanol/buffer partition coefficient was also consistent with the prominent reversible association of ADM with the vasculature of the BBB.	Octanols	47-54	adrenomedullin	Homo sapiens	25-28
11280710-9	2001	The low lipophilicity of ADM determined by the octanol/buffer partition coefficient was also consistent with the prominent reversible association of ADM with the vasculature of the BBB.	Octanols	47-54	adrenomedullin	Homo sapiens	149-152
12146632-5	2002	Increasing ELUMO (the energy of the lowest unoccupied molecular orbital) values of the PCBs leads to decreasing logK(OA) values, indicating possible interactions between PCB and octanol molecules.	Octanols	178-185	pyruvate carboxylase	Homo sapiens	87-90
12146632-6	2002	Increasing Q(Cl)+, (the most positive net atomic charges on a chlorine atom) and Q(C)- (the largest negative net atomic charge on a carbon atom) values of PCBs results in decreasing lg K(OA) values, implying possible intermolecular electrostatic interactions between octanol and PCB molecules.	Octanols	267-274	pyruvate carboxylase	Homo sapiens	155-158
11891568-8	2002	In excised membrane patches, application of flufenamic acid or octanol to the extracellular surface of Cx50 hemichannels reduced single channel-open probability without altering the single-channel conductance, but application to the cytoplasmic surface had no effect on the channels.	Octanols	63-70	gap junction protein, alpha 8	Rattus norvegicus	103-107
12751910-4	2002	Quantitative Structure-Activity Relationships (QSARs) for substrates binding to CYP2B6 indicate a key role for hydrogen bonding, and lipophilic character, as determined by the log P parameter (where P is the octanol/water partition coefficient), is also of importance for explaining the variation in experimental binding affinity for CYP2B6 substrates.	Octanols	208-215	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	80-86
11712605-5	2001	Seventy percent of the variation of the PCB particulate-dissolved phase coefficient (Kd) was correlated with temperature and log octanol-water (Kow)).	Octanols	129-136	pyruvate carboxylase	Homo sapiens	40-43
11811064-2	2001	Octyl beta-D-galactopyranoside and octyl beta-D-glucopyranoside were synthesized from the corresponding sugars (lactose or glucose) and octyl alcohol under catalysis with glycolytic enzymes, beta-galactosidase and beta-glucosidase, respectively.	Octanols	136-149	galactosidase beta 1	Homo sapiens	191-209
12545455-1	2001	A new silane coupling agent, beta-(3,4-epoxycyclohexyl)ethyltrimethoxy silane, was for the firsty time used to react with octanol, then the intermediate product was coupled onto porous silica to obtain a novel bonded phase for reversed-phase high performance liquid chromatography (RP-HPLC).	Octanols	122-129	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	29-38
11476596-6	2001	We found that the vulnerable CA1/CA2 subfields have a higher density of gap junctions than the resistant CA3/CA4 areas, that changes in the distribution of connexin43 immunoreactivity may correlate with the phenomenon of selective vulnerability, and that inhibition of astrocytic gap junction permeability by octanol restricts the flow of undesirable neurotoxins that could potentially exacerbate neuronal damage.	Octanols	309-316	carbonic anhydrase 1	Homo sapiens	29-32
11476596-6	2001	We found that the vulnerable CA1/CA2 subfields have a higher density of gap junctions than the resistant CA3/CA4 areas, that changes in the distribution of connexin43 immunoreactivity may correlate with the phenomenon of selective vulnerability, and that inhibition of astrocytic gap junction permeability by octanol restricts the flow of undesirable neurotoxins that could potentially exacerbate neuronal damage.	Octanols	309-316	gap junction protein alpha 1	Homo sapiens	156-166
11708139-4	2001	A quantitative structure-activity relationship was obtained to describe the AA of flavonoids: IC50(microM) = 30.36 + 151.50 E1/2 (V) -12.63 log P (r = 0.852), where IC50 represents the concentration for 50% inhibition of LPO, and P represents the octanol/water partition coefficient.	Octanols	247-254	small nucleolar RNA, H/ACA box 73A	Homo sapiens	124-132
10771139-7	2000	The potency to induce hsp70 was significantly correlated to the octanol-water partition coefficient (log K(ow)) of the inducing chemicals, except for 1-chloro-2,4-dinitrobenzene and ethyl parathion.	Octanols	64-71	heat shock protein family A (Hsp70) member 4	Homo sapiens	22-27
10997577-2	2000	Circadian rhythms in AVP and VIP release maintained when the SCN culture was treated with octanol for 42 h. However, the release of AVP and VIP showed no circadian rhythms after 7 days incubation with octanol or halothane.	Octanols	90-97	arginine vasopressin	Rattus norvegicus	21-24
10997577-2	2000	Circadian rhythms in AVP and VIP release maintained when the SCN culture was treated with octanol for 42 h. However, the release of AVP and VIP showed no circadian rhythms after 7 days incubation with octanol or halothane.	Octanols	90-97	vasoactive intestinal peptide	Rattus norvegicus	29-32
7491971-7	1995	Halothane inhibited inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] production in response to both 1 and 10 nM CCK (31 and 40% inhibition, respectively), possibly explaining its effects on [Ca2+]i oscillations, whereas octanol showed no significant inhibition.	Octanols	215-222	cholecystokinin	Homo sapiens	107-110
10701943-3	1999	The binding of phenoxazine derivatives to bovine serum albumin is correlated with their octanol-water partition coefficient, log10P.	Octanols	88-95	albumin	Homo sapiens	49-62
9815015-7	1998	Intragastric perfusion with octanol caused a significant reduction in immunoreactive connexin-32 spots, which was completely reversed by irsogladine.	Octanols	28-35	gap junction protein, beta 1	Rattus norvegicus	85-96
9825706-0	1998	The effects of octanol on the late photointermediates of rhodopsin.	Octanols	15-22	rhodopsin	Homo sapiens	57-66
9744955-7	1998	Microinjection into CA1 stratum radiatum of octanol (1 mM), which when bath applied arrests the spread of normoxic SD, created a small focus that appeared to be protected from hypoxic depolarization.	Octanols	44-51	carbonic anhydrase 1	Rattus norvegicus	20-23
9531510-4	1998	The isolated enzyme has, as well, several characteristics that are unique to alcohol dehydrogenase (ADH) class III isoenzyme: it is capable of catalysing the NAD+-dependent oxidations of octanol (insensitive to inhibition by 4-methylpyrazole), methylcrotyl alcohol (stimulated by added pentanoate) and 12-hydroxydodecanoic acid, and also the NADH/NADPH-dependent reduction of octanal.	Octanols	187-194	alcohol dehydrogenase 5 (class III), chi polypeptide	Rattus norvegicus	100-103
9105729-8	1997	Pretreatment of the cells with octanol to block gap junctions, or with EGTA or La3+ to inhibit Ca2+ influx, abolished the synchronization induced by bradykinin or thrombin.	Octanols	31-38	kininogen 1	Canis lupus familiaris	149-159
8998290-6	1996	Catalase dissociation to monomers is significantly decreased in mixed micelles composed of AOT, Triton X-45, Triton X-100, or Tween-85 and octanol.	Octanols	139-146	catalase	Homo sapiens	0-8
8735641-11	1996	Furthermore, butanol, hexanol, octanol, and decanol produce similar potentiation of GABAA receptor function at concentrations required to cause loss of righting reflex in tadpoles, an in vivo model where alcohol distribution is not a compromising factor.	Octanols	31-38	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	84-89
8741017-3	1996	Octanol-water partition coefficients (P(ow)) are correlated with these four surface-MEP descriptors: log P(ow) = c0 + c1B+F + c2B-F + c3B+R + c4B-R.	Octanols	0-7	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	142-147
8901074-4	1996	The obtained order of the solubilities in pure octanol was 5-MOP approximately TMP > P > 8-MOP, while in water-saturated octanol it was expressed as follows: TMP approximately 5-MOP > P > 8-MOP.	Octanols	47-54	opioid receptor mu 1	Homo sapiens	61-64
8901074-4	1996	The obtained order of the solubilities in pure octanol was 5-MOP approximately TMP > P > 8-MOP, while in water-saturated octanol it was expressed as follows: TMP approximately 5-MOP > P > 8-MOP.	Octanols	47-54	opioid receptor mu 1	Homo sapiens	97-100
8901074-4	1996	The obtained order of the solubilities in pure octanol was 5-MOP approximately TMP > P > 8-MOP, while in water-saturated octanol it was expressed as follows: TMP approximately 5-MOP > P > 8-MOP.	Octanols	47-54	opioid receptor mu 1	Homo sapiens	97-100
8901074-4	1996	The obtained order of the solubilities in pure octanol was 5-MOP approximately TMP > P > 8-MOP, while in water-saturated octanol it was expressed as follows: TMP approximately 5-MOP > P > 8-MOP.	Octanols	47-54	opioid receptor mu 1	Homo sapiens	97-100
10606766-4	2000	Moreover, rat ADHII-catalyzed rates of ethanol dehydrogenation are markedly lower than octanol or retinoid dehydrogenation rates.	Octanols	87-94	alcohol dehydrogenase 4 (class II), pi polypeptide	Rattus norvegicus	14-19
10669039-4	1999	All diacid forms of ACE inhibitors are dissociated at a pH of 7.4 and scarcely extractable into octanol (extraction coefficient < 10%).	Octanols	96-103	angiotensin I converting enzyme	Bos taurus	20-23
10586545-8	1999	This improved method is a simple technique for determination of the rCBF by 123I-IMP microsphere model and one-point arterial blood sampling which no longer shows a time limitation and does not require any octanol extraction step.	Octanols	206-213	CCAAT/enhancer binding protein zeta	Rattus norvegicus	68-72
10087007-9	1999	The octanol/buffer partition coefficient of 0.232 showed that orexin A was highly lipophilic, whereas the value for orexin B was only 0.030.	Octanols	4-11	hypocretin	Mus musculus	62-70
9705994-8	1998	Halothane, heptanol and octanol, which are commonly used as gap junction inhibitors, drastically reduced the amplitude of Et1-induced calcium responses.	Octanols	24-31	endothelin 1	Rattus norvegicus	122-125
9375354-1	1997	Sorption partition coefficients between water and organic carbon (Koc) for deuterated benzene, toluene, and ethylbenzene have been estimated by measuring values of the octanol-water partition coefficient (Kow) and HPLC retention factors (k1), which correlate closely to values of Koc.	Octanols	168-175	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	66-69
8702573-3	1996	When rhodopsin was photolyzed in the presence of several n-alcohols, increased MII formation was observed in the order ethanol > butanol > hexanol, whereas longer chain n-alcohols inhibited MII formation with decanol > octanol.	Octanols	228-235	rhodopsin	Homo sapiens	5-14
7812185-3	1994	For DCCD, AI, NBD-Cl and TNM there is a good correlation between the phase partition in octanol/water and the ability to cross or not the inner mitochondrial membrane.	Octanols	88-95	teneurin transmembrane protein 1	Homo sapiens	25-28
8655189-6	1995	A linear relationship was obtained between log K (the partitioning of the beta-blocker in DMPC and also in octanol/water) and the potencies of these beta1-antagonists.	Octanols	107-114	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	149-154
7884677-4	1994	The slopes of plots of log PRX vs log KRX were 0.85, 0.91, 0.99, and 2.4, respectively, for hexadecane/water, hexadecene/water, 1,9-decadiene/water, and octanol/water with the best model solvent being that which yielded a slope closest to unity.	Octanols	153-160	periaxin	Homo sapiens	27-30
8643385-5	1995	Octanol-H2O partitioning free energies of peptides which (i) straddle the proteolysis site, and (ii) form the "side" and "bottom" of the proposed "lid" were found to only slightly favor H2O, suggesting that the peptide is poised to detach from the less polar surface surrounding the RIP active site.	Octanols	0-7	ribosome-inactivating protein	Zea mays	283-286
8405904-8	1993	However, both heptanol and octanol at 1 mM blocked the hCG and progesterone induction of maturation in follicle-enclosed Xenopus oocytes.	Octanols	27-34	hypertrichosis 2 (generalised, congenital)	Homo sapiens	55-58
8027781-5	1994	Under conditions that reduce gap junctional conductance (intracellular acidification, octanol, halothane), seizure-like activity was suppressed in the CA1 area in this epilepsy model, whereas increasing gap junctional conductance by intracellular alkalinization increased the frequency and duration of field burst events.	Octanols	86-93	carbonic anhydrase 1	Homo sapiens	151-154
8010482-6	1994	The effects of halothane, isoflurane, and octanol on TRH-induced Ca2+ mobilization were assessed as a function of time and anesthetic concentration.	Octanols	42-49	thyrotropin releasing hormone	Rattus norvegicus	53-56
8010482-11	1994	Isoflurane and octanol also produced concentration-dependent inhibition of the [Ca2+]i response to TRH.	Octanols	15-22	thyrotropin releasing hormone	Rattus norvegicus	99-102
8366115-6	1993	Octanol inhibited ongoing oscillations evoked by focal or global bombesin stimulation.	Octanols	0-7	gastrin releasing peptide	Homo sapiens	65-73
1735699-2	1992	The in vivo tumor/plasma partition coefficient (PTP) of sensitizers increased with increase in the octanol/water partition coefficient (Pow) up to approximately 0.3 and was almost unity (maximum) for sensitizers with their Pow values larger than approximately 0.3.	Octanols	99-106	protein tyrosine phosphatase receptor type U	Homo sapiens	48-51
1331136-14	1992	Consistent with the observed Cx43 immunostaining, octanol-sensitive in situ dye-coupling was observed between Leydig cells, between peritubular cells and between Sertoli cells, suggesting the occurrence of functional gap junctions in these cell types.	Octanols	50-57	gap junction protein, beta 1	Mus musculus	29-33
1327187-2	1992	The solubility of myeloperoxidase in 1-octanol and octanol was determined.	Octanols	39-46	myeloperoxidase	Rattus norvegicus	18-33
15092109-5	1991	The losses of PAH compounds in these field experiments can be related, in part, to their physico-chemical properties, notably the octanol: water partition coefficient.	Octanols	130-137	phenylalanine hydroxylase	Homo sapiens	14-17
1782213-8	1991	The PAF response was also inhibited by ruthenium red or octanol and potentiated by caffeine, suggesting that CICR plays a physiological role in these cells.	Octanols	56-63	PCNA clamp associated factor	Homo sapiens	4-7
2260984-5	1990	These trifluoromethyl ketones were found to be rapidly reversible, competitive inhibitors of NTE with I50 values 1.3 x 10(-4) M to 4.9 x 10(-8) M. Correlation of I50 values with octanol/water partition coefficients (P), in the range of log P = 1.5 to 5.9. indicated that the optimal lipophilicity for NTE substrates and inhibitors is in the range of log P = 3.0 to 3.4.	Octanols	178-185	patatin like phospholipase domain containing 6	Gallus gallus	93-96
2632084-4	1989	In order to predict how changes in the secretin molecule would affect its absorption through the nasal mucosa independently of structural changes in the epithelial membrane, an artificial membrane permeation test was conducted, and the apparent partition coefficient between octanol and a test solution was determined.	Octanols	275-282	secretin	Rattus norvegicus	39-47
2258008-10	1990	t-Butanol, pentanol, hexanol, and octanol significantly decreased the LD50 of CCl4.	Octanols	34-41	C-C motif chemokine ligand 4	Rattus norvegicus	78-82
34847430-7	2022	A suitable water-octanol partition coefficient (logP, 0.521 +- 0.003) and low cytotoxicity displayed that NCR is very favorable to image living cells.	Octanols	17-24	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	106-109
34995697-3	2022	While the size and zeta-potential of polyplexes were comparable among various PAsp(DET/R)s, the transfection efficiencies of polyplexes were considerably varied due to difference in the R moieties of PAsp(DET/R)s and were described by an octanol-water (or buffer at pH 7.3) distribution coefficient (logD7.3).	Octanols	238-245	carboxypeptidase B1	Homo sapiens	200-204
2374929-4	1990	Also, the calcium responses to activation of the amphibian AII receptor, but not the expressed mammalian AII receptor, were blocked reversibly by octanol and intracellular acidification, treatments that inhibit cell coupling through gap junctions.	Octanols	146-153	angiotensinogen	Homo sapiens	59-62
34673427-7	2021	The log BAF values of SCCP homologues (1.33-4.75) increased significantly with the increase of their logarithm octanol-water partition coefficients (log KOW) values, indicating that hydrophobicity is the major factor controlling the bioaccumulation of SCCPs.	Octanols	111-118	BAF nuclear assembly factor 1	Homo sapiens	8-11
2819035-5	1989	The comparison of substrate specificity among beta beta isoenzymes for primary straight-chain alcohols indicates that there is a positive correlation between Vmax/KM and the log octanol/water partition coefficient for alcohols with beta 2 beta 2 and beta 3 beta 3 but not with beta 1 beta 1.	Octanols	178-185	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	232-238
2819035-5	1989	The comparison of substrate specificity among beta beta isoenzymes for primary straight-chain alcohols indicates that there is a positive correlation between Vmax/KM and the log octanol/water partition coefficient for alcohols with beta 2 beta 2 and beta 3 beta 3 but not with beta 1 beta 1.	Octanols	178-185	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	239-245
2563651-3	1989	There was a positive correlation between the octanol/water partition coefficients of these agents and their inhibition of lipoprotein lipase, suggesting that hydrophobicity may be one of the major determinants for PHLpL inhibition.	Octanols	45-52	lipoprotein lipase	Homo sapiens	122-140
16662797-6	1983	Among those compounds possessing an o-dihydroxy function, the K(i)" for inhibition of lipoxygenase is directly related to the lipophilicity of the inhibitor as measured by the octanol-water partition coefficient.	Octanols	176-183	linoleate 9S-lipoxygenase-4	Glycine max	86-98
3675616-3	1987	The serum cholinesterase was inhibited by all those compounds, their relative potencies being proportional to their octanol/water partition coefficients.	Octanols	116-123	cholinesterase	Oryctolagus cuniculus	10-24
2939242-1	1986	An analysis of the inhibition constants of pyrazoles, phenylacetamides, formylbenzylamines, and acetamides acting on liver alcohol dehydrogenase (ADH) yields quantitative structure-activity relationships (QSAR) having a linear dependency on octanol-water partition coefficients (log P).	Octanols	241-248	aldo-keto reductase family 1 member A1	Homo sapiens	123-144
2939242-1	1986	An analysis of the inhibition constants of pyrazoles, phenylacetamides, formylbenzylamines, and acetamides acting on liver alcohol dehydrogenase (ADH) yields quantitative structure-activity relationships (QSAR) having a linear dependency on octanol-water partition coefficients (log P).	Octanols	241-248	aldo-keto reductase family 1 member A1	Homo sapiens	146-149
4066687-6	1985	The octanol/saline partition coefficients of radioactive iron in solution with transferrin, nitrilotriacetic acid, or chloride were all less than 0.06.	Octanols	4-11	transferrin	Homo sapiens	79-90
6747992-0	1984	The preferred solution conformation of warfarin at the active site of cytochrome P-450 based on the CD spectra in octanol/water model system.	Octanols	114-121	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-86
6132789-5	1983	A correlation was observed between the octanol-buffer or heptane-buffer distribution ratios of the compounds and the negative logarithm of the Michaelis constant (pKm) for the enzyme in control microsomes and for each of the enzyme systems in microsomes from phenobarbital-pretreated animals.	Octanols	39-46	pyruvate kinase M1/2	Rattus norvegicus	163-166
7199109-3	1981	When octanol is oxidized in aerobic conditions, cytochrome b is reduced, with the absorption maxima in alpha, beta and gamma bands being at 555, 526 and 425 nm, respectively.	Octanols	5-12	mitochondrially encoded cytochrome b	Homo sapiens	48-60