PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18585370-6	2008	Several synthesized TAA derivates of 6-methyluracil reversibly inhibited electric eel and cobra venom AChEs and horse serum BuChE.	6-methyluracil	37-51	butyrylcholinesterase	Homo sapiens	124-129
23652433-0	2013	Specific inhibitory effects of the alkylammonium derivative 6-methyluracil on acetylcholinesterase of smooth and striated muscles in rats.	6-methyluracil	60-74	acetylcholinesterase	Rattus norvegicus	78-98
19331513-1	2009	Derivative of 6-methyluracil, selective cholinesterase inhibitor C-547 potentiates miniature endplate currents (MEPCs) in rat external intercostal muscles (external ICM) more effectively than in internal intercostal muscles (internal ICM).	6-methyluracil	14-28	butyrylcholinesterase	Rattus norvegicus	40-54
21232040-1	2011	BACKGROUND AND PURPOSE: The rat respiratory muscle diaphragm has markedly lower sensitivity than the locomotor muscle extensor digitorum longus (EDL) to the new acetylcholinesterase (AChE) inhibitors, alkylammonium derivatives of 6-methyluracil (ADEMS).	6-methyluracil	230-244	acetylcholinesterase	Rattus norvegicus	183-187
17929660-0	2007	Effect of a tetraalkylammonium derivative of 6-methyluracil from a new class of acetylcholinesterase inhibitors on the endplate potential amplitude in muscles of different function types under high-frequency nerve stimulation.	6-methyluracil	45-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-100
11712130-0	2001	Tetraalkylammonium derivatives of 6-methyluracil, a new class of cholinesterase inhibitors: characteristics of interaction with cholinesterases from different groups of animals.	6-methyluracil	34-48	butyrylcholinesterase	Homo sapiens	65-79
15863308-1	2005	Uracil derivatives were designed and synthesized to avoid atropisomers observed in the 6-methyluracils as antagonists of the human GnRH receptor.	6-methyluracil	87-102	gonadotropin releasing hormone receptor	Homo sapiens	131-144
14971906-2	2004	The synthesis and SAR studies of 6-methyluracils as human GnRH receptor antagonists are discussed herein.	6-methyluracil	33-48	gonadotropin releasing hormone receptor	Homo sapiens	58-71
12951116-1	2003	The novel synthesis and SAR studies of 6-methyluracils as human GnRH receptor antagonists are discussed.	6-methyluracil	39-54	gonadotropin releasing hormone receptor	Homo sapiens	64-77
16196024-1	2005	1-(2,6-Difluorobenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil (6), a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor, exists as a pair of atropisomers in solution, which was detected by NMR spectroscopy, and separable by HPLC.	6-methyluracil	77-93	gonadotropin releasing hormone receptor	Homo sapiens	150-189
4002833-2	1985	The preferential site of attack is the C(5) position (values in brackets) in the case of 6-methyluracil (87%), 1,3-dimethyluracil (71%), uracil (69%) and poly(U) (60%).	6-methyluracil	89-103	complement C5	Homo sapiens	39-43
7914250-1	1994	6-Methyluracil (6MU) has been identified in urine collected during acute illness in two children with beta-ketothiolase deficiency (approximately 1 mmol/L) and in two children with recurrent infection-related ketoacidaemia of unknown aetiology (levels of 6.3 and 7.1 mmol/mmol creatinine).	6-methyluracil	0-14	acetyl-CoA acyltransferase 1	Homo sapiens	102-119
7914250-1	1994	6-Methyluracil (6MU) has been identified in urine collected during acute illness in two children with beta-ketothiolase deficiency (approximately 1 mmol/L) and in two children with recurrent infection-related ketoacidaemia of unknown aetiology (levels of 6.3 and 7.1 mmol/mmol creatinine).	6-methyluracil	16-19	acetyl-CoA acyltransferase 1	Homo sapiens	102-119
8498068-1	1993	Single intraperitoneal administration of 6-methyluracil in a dose of 50 mg/kg was shown to affect some patterns of the physico-chemical system regulating lipid peroxidation in mice liver tissue and erythrocytes: antioxidative activity of lipids (AOA), composition of phospholipids; the drug altered also activities of superoxide dismutase and catalase in liver tissue and blood serum of rats.	6-methyluracil	41-55	catalase	Mus musculus	343-351
1467354-2	1992	During the first 24 hours after injection both carnosine and 4-methyluracil increase the activity of adenosine deaminase and purine nucleoside phosphorylase, the key enzymes of purine catabolism which is the main source of O2-.	6-methyluracil	61-75	adenosine deaminase	Mus musculus	101-120
1467355-1	1992	A comparative study of the hepatoprotective effect of carnosine and 4-methyluracil under CCl4-induced acute toxic hepatitis has been carried out.	6-methyluracil	68-82	C-C motif chemokine ligand 4	Rattus norvegicus	89-93
974125-5	1976	The relative reactivities of 6-methyluracil: uracil: thymine are 1: 23 : 194 and the bimolecular oxidation process is characterized by relatively small deltaH++ values and large negative deltaS++ values.	6-methyluracil	29-43	VPS52 subunit of GARP complex	Homo sapiens	61-66
26639718-31	2015	CONCLUSIONS: Experiments showed that the most potent AChE inhibitor compound 35 (6-methyluracil derivative) permeated the blood-brain barrier, improved working memory in the APP/PS1 transgenic mice and significantly reduced the number and area of Abeta plaques in the brain.	6-methyluracil	81-95	presenilin 1	Mus musculus	178-181
26639720-0	2015	Macrocyclic derivatives of 6-methyluracil: New ligands of the peripheral anionic site of acetylcholinesterase.	6-methyluracil	27-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	89-109
26639720-13	2015	RESULTS: We described previously a new class of selective mammalian AChE vs. butyrylcholinesterase (BChE) inhibitors based on alkylammonium derivatives of 6-methyluracil of acyclic topology [7].	6-methyluracil	155-169	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
31675511-0	2020	6-Methyluracil derivatives as peripheral site ligand-hydroxamic acid conjugates: Reactivation for paraoxon-inhibited acetylcholinesterase.	6-methyluracil	0-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	117-137
31675511-1	2020	New uncharged conjugates of 6-methyluracil derivatives with imidazole-2-aldoxime and 1,2,4-triazole-3-hydroxamic acid units were synthesized and studied as reactivators of organophosphate-inhibited cholinesterase.	6-methyluracil	28-42	butyrylcholinesterase	Homo sapiens	198-212
31675511-2	2020	Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro.	6-methyluracil	67-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	165-185
31675511-2	2020	Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro.	6-methyluracil	67-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	187-191
26929400-0	2016	Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment.	6-methyluracil	82-96	acetylcholinesterase (Cartwright blood group)	Homo sapiens	27-47
26929400-1	2016	Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, C-547, a potential drug for the treatment of MG (myasthenia gravis) was studied.	6-methyluracil	115-129	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-24
26929400-1	2016	Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, C-547, a potential drug for the treatment of MG (myasthenia gravis) was studied.	6-methyluracil	115-129	acetylcholinesterase (Cartwright blood group)	Homo sapiens	26-46
26929400-1	2016	Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, C-547, a potential drug for the treatment of MG (myasthenia gravis) was studied.	6-methyluracil	115-129	butyrylcholinesterase	Homo sapiens	52-56
26929400-1	2016	Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, C-547, a potential drug for the treatment of MG (myasthenia gravis) was studied.	6-methyluracil	115-129	butyrylcholinesterase	Homo sapiens	58-79
26639720-13	2015	RESULTS: We described previously a new class of selective mammalian AChE vs. butyrylcholinesterase (BChE) inhibitors based on alkylammonium derivatives of 6-methyluracil of acyclic topology [7].	6-methyluracil	155-169	butyrylcholinesterase	Homo sapiens	77-98
26639720-13	2015	RESULTS: We described previously a new class of selective mammalian AChE vs. butyrylcholinesterase (BChE) inhibitors based on alkylammonium derivatives of 6-methyluracil of acyclic topology [7].	6-methyluracil	155-169	butyrylcholinesterase	Homo sapiens	100-104
26639720-14	2015	In the present study, taking acyclic derivatives of 6-methyluracil as a model AChE inhibitor, we attempted to develop AChE inhibitors that specifically bind to the PAS with weak binding to the active site of AChE.	6-methyluracil	52-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-82
26639720-14	2015	In the present study, taking acyclic derivatives of 6-methyluracil as a model AChE inhibitor, we attempted to develop AChE inhibitors that specifically bind to the PAS with weak binding to the active site of AChE.	6-methyluracil	52-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-122
26639720-14	2015	In the present study, taking acyclic derivatives of 6-methyluracil as a model AChE inhibitor, we attempted to develop AChE inhibitors that specifically bind to the PAS with weak binding to the active site of AChE.	6-methyluracil	52-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-122