PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29197963-0	2018	Synthesis and biological evaluation of imidazo[1,2-[Formula: see text]]pyridazines as inhibitors of TNF-[Formula: see text] production.	Pyridazines	71-82	tumor necrosis factor	Homo sapiens	100-103
31852269-2	2019	In our quest towards the development of novel scaffolds for effective vascular endothelial growth 2 (VEGFR-2) inhibition with antiangiogenic activity, four novel series of pyridazines were designed and synthesised.	Pyridazines	172-183	kinase insert domain receptor	Homo sapiens	101-108
34267872-0	2021	Novel Pyridazines as Autotaxin Inhibitors for Treating Inflammatory Airway or Fibrotic Diseases.	Pyridazines	6-17	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	21-30
2481842-5	1989	The fact that the amount of free bases released from calf thymus DNA corresponded well to the amount of pyridazines indicates this reaction can be used for detection of C-4"-hydroxylated abasic site in DNA.	Pyridazines	104-115	complement C4	Bos taurus	169-172
33859788-0	2021	Novel Pyridazines as Autotaxin Inhibitors for Treating Inflammatory Airway or Fibrotic Diseases.	Pyridazines	6-17	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	21-30
32781872-0	2020	Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights.	Pyridazines	31-42	cyclin dependent kinase 2	Homo sapiens	91-116
32781872-8	2020	Furthermore, an in silico study proposed CDK2 as a probable enzymatic target for pyridazines 11, and explored their binding interactions within the vicinity of CDK2 binding site.	Pyridazines	81-92	cyclin dependent kinase 2	Homo sapiens	41-45
32781872-8	2020	Furthermore, an in silico study proposed CDK2 as a probable enzymatic target for pyridazines 11, and explored their binding interactions within the vicinity of CDK2 binding site.	Pyridazines	81-92	cyclin dependent kinase 2	Homo sapiens	160-164
32781872-9	2020	Subsequently, pyridazines 11e, 11h, 11l, and 11m were selected to be evaluated for their ability to inhibit CDK2, where they exerted good inhibitory activity (IC50 = 151, 43.8, 55.6 and 20.1 nM, respectively).	Pyridazines	14-25	cyclin dependent kinase 2	Homo sapiens	108-112
24107108-9	2013	More recently a number of nonimidazole based p38 inhibitors such as the ureas, pyrazoles, pyrazoloheteroaryls, pyridazines, indoles, amides, pyridines, triazolopyridines, etc containing a variety of functionality have been reported to inhibit cytokine activity.	Pyridazines	111-122	mitogen-activated protein kinase 14	Homo sapiens	45-48
26077492-0	2015	Design, synthesis and evaluation of MCH receptor 1 antagonists--Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition.	Pyridazines	89-100	melanin concentrating hormone receptor 1	Homo sapiens	36-50
26077492-0	2015	Design, synthesis and evaluation of MCH receptor 1 antagonists--Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition.	Pyridazines	89-100	ETS transcription factor ERG	Homo sapiens	137-141
22530929-6	2012	By establishing the need for electron-withdrawing resonant groups in the 3- and 6-positions to stabilize the critical intermediate in the initial stages of the reaction, this work suggests that the scope of the reductive ring contraction of 1,2-pyridazines may be expanded to pyridazines bearing COCH(3) groups, amides or aryls in these positions.	Pyridazines	245-256	cochlin	Homo sapiens	296-300
22913544-0	2012	Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and beta-amyloid plaques in Alzheimer"s disease models.	Pyridazines	43-55	microtubule associated protein tau	Homo sapiens	78-81
21755085-0	2011	Substituted pyridazines as ligands in homoleptic (fac and mer) and heteroleptic Ru(II) complexes.	Pyridazines	12-23	FA complementation group C	Homo sapiens	50-53
16290144-0	2006	Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones.	Pyridazines	0-11	sarcosine dehydrogenase	Homo sapiens	58-61
9748356-0	1998	Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships.	Pyridazines	47-58	monoamine oxidase B	Homo sapiens	14-33
9748356-5	1998	Thus, while most of the condensed pyridazines were reversible inhibitors of MAO-B with little or no MAO-A effects, the pyrimidine derivatives proved to be reversible and selective MAO-A inhibitors.	Pyridazines	34-45	monoamine oxidase B	Homo sapiens	76-81