PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12810581-7	2003	Pirenzepine (M1 antagonist; 10-1000 microM) and gallamine (M2 antagonist; 10-1000 microM) completely inhibited bethanechol-induced GLP-1 secretion, whereas 4-diphenylacetoxy-N-methylpiperidine (M3 antagonist) had no effect on bethanechol-stimulated GLP-1 secretion.	Gallamine Triethiodide	48-57	glucagon	Homo sapiens	131-136
18061357-4	2008	methoctramine in the CA1 region of urethane-anesthetized rats was mimicked by gallamine, an M2 receptor antagonist, supporting a role for this receptor subtype.	Gallamine Triethiodide	78-87	carbonic anhydrase 1	Rattus norvegicus	21-24
17944454-1	2007	Gallamine and tacrine are allosteric antagonists at muscarinic M2 acetylcholine receptors and inhibitors of acetylcholinesterase.	Gallamine Triethiodide	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-128
17944454-2	2007	At both acetylcholine-binding proteins, gallamine and tacrine are known to occupy two different binding sites: in M2 receptors within the allosteric binding area and in acetylcholinesterase at its catalytic and its peripheral site.	Gallamine Triethiodide	40-49	acetylcholinesterase (Cartwright blood group)	Homo sapiens	169-189
17588565-4	2007	These data indicate that vecuronium, gallamine and pancuronium interact with an allosteric site on the muscarinic M2 receptor (located on the heart) and this may explain some of their cardiac side effects.	Gallamine Triethiodide	37-46	cholinergic receptor muscarinic 2	Homo sapiens	103-125
17024678-4	2006	In situ microelectrophoretic application of the muscarinic M2 subtype cholinergic receptor agonist cis-dioxolane, DHEAS, and ES markedly reduced PPI in the dentate and CA1 that was blocked by the M2 receptor antagonist gallamine.	Gallamine Triethiodide	219-228	carbonic anhydrase 1	Homo sapiens	168-171
17206516-3	2006	Similar to Shaker K channels, gallamine block of Kv3.1 channels was more sensitive to solution ionic strength than was TEA block, a result consistent with a contribution from an electrostatic potential near the blocking site.	Gallamine Triethiodide	30-39	potassium voltage-gated channel subfamily C member 1	Homo sapiens	49-54
17206516-6	2006	Kv2.1 channels with both lysines neutralized were sensitive to block by gallamine, and the ionic strength dependence of this block was greater than that for TEA.	Gallamine Triethiodide	72-81	potassium voltage-gated channel subfamily B member 1	Homo sapiens	0-5
12021207-8	2002	Pirenzepine and gallamine significantly inhibited bethanechol-stimulated GLP-1 secretion, by 96 +/- 12% and 98 +/- 8%, respectively (P < 0.01).	Gallamine Triethiodide	16-25	glucagon	Rattus norvegicus	73-78
12505979-3	2003	A novel crystal form of mouse AChE, combined with spectrophotometric analyses of the crystals, enabled us to solve unique structures of AChE with a free peripheral site, and as three complexes with peripheral site inhibitors: the phenylphenanthridinium ligands, decidium and propidium, and the pyrogallol ligand, gallamine, at 2.20-2.35 A resolution.	Gallamine Triethiodide	313-322	acetylcholinesterase	Mus musculus	30-34
12505979-3	2003	A novel crystal form of mouse AChE, combined with spectrophotometric analyses of the crystals, enabled us to solve unique structures of AChE with a free peripheral site, and as three complexes with peripheral site inhibitors: the phenylphenanthridinium ligands, decidium and propidium, and the pyrogallol ligand, gallamine, at 2.20-2.35 A resolution.	Gallamine Triethiodide	313-322	acetylcholinesterase	Mus musculus	136-140
11392621-6	2001	A model of the M1 receptor, based on the recently determined structure of rhodopsin, has the residues that have been shown to be important for gallamine binding clustered within and to one side of a cleft in the extracellular face of the receptor.	Gallamine Triethiodide	143-152	rhodopsin	Homo sapiens	74-83
11435054-1	2001	STUDY OBJECTIVE: To determine if pretreatment with either gallamine or mivacurium before succinylcholine in children is associated with reduction in fasciculations; postoperative myalgias; or serum levels of potassium, creatinine phosphokinase (CPK), and myoglobin.	Gallamine Triethiodide	58-67	myoglobin	Homo sapiens	255-264
9020401-0	1997	The inhibitory effect of the neuromuscular blocking agent, gallamine triethiodide, on camel retina acetylcholinesterase activity.	Gallamine Triethiodide	59-81	acetylcholinesterase	Camelus bactrianus	99-119
10619655-4	1999	The action of AChE was not affected by edrophonium and tacrine both active site inhibitors, but it was abolished by propidium and gallamine, two peripheral anionic binding site (PAS) ligands.	Gallamine Triethiodide	130-139	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-18
9020401-1	1997	The present investigation addresses the mode of inhibition of the camel retinal acetylcholinesterase (AChE) activity by gallamine triethiodide, which is known to be a specific non-depolarizing neuromuscular blocking agent and polar cholinergic antagonist.	Gallamine Triethiodide	120-142	acetylcholinesterase	Camelus bactrianus	80-100
9020401-1	1997	The present investigation addresses the mode of inhibition of the camel retinal acetylcholinesterase (AChE) activity by gallamine triethiodide, which is known to be a specific non-depolarizing neuromuscular blocking agent and polar cholinergic antagonist.	Gallamine Triethiodide	120-142	acetylcholinesterase	Camelus bactrianus	102-106
9020401-2	1997	This study gave the following results: it was found that gallamine (GA) reversibly inhibited the AChE activity in a concentration dependent manner, the IC50 being about 0.633 mM.	Gallamine Triethiodide	57-66	acetylcholinesterase	Camelus bactrianus	97-101
9020401-2	1997	This study gave the following results: it was found that gallamine (GA) reversibly inhibited the AChE activity in a concentration dependent manner, the IC50 being about 0.633 mM.	Gallamine Triethiodide	68-70	acetylcholinesterase	Camelus bactrianus	97-101
8114681-1	1994	Comparison of the effect of three "peripheral" site ligands, propidium, d-tubocurarine, and gallamine, on acetylcholinesterase (acetylcholine hydrolase; EC 3.1.1.7) of Torpedo and chicken shows that all three are substantially more effective inhibitors of the Torpedo enzyme than of the chicken enzyme.	Gallamine Triethiodide	92-101	acetylcholinesterase (Cartwright blood group)	Gallus gallus	106-126
7819544-1	1994	The effect of the muscarinic M1 and M2 antagonists (pirenzepine and gallamine) on heterosynaptic short-term depression (HSTD) of the CA1 population spike was studied in rat hippocampal slices.	Gallamine Triethiodide	68-77	carbonic anhydrase 1	Rattus norvegicus	133-136
8825340-8	1996	The same three compounds inhibited angiotensin II-evoked K+ loss from guinea-pig hepatocytes in the order dequalinium > UCL 1530 > gallamine, with an equi-effective molar ratio for gallamine to UCL 1530 of 5.8, 150 fold less than in sympathetic neurones.	Gallamine Triethiodide	137-146	angiotensinogen	Rattus norvegicus	35-49
8825340-8	1996	The same three compounds inhibited angiotensin II-evoked K+ loss from guinea-pig hepatocytes in the order dequalinium > UCL 1530 > gallamine, with an equi-effective molar ratio for gallamine to UCL 1530 of 5.8, 150 fold less than in sympathetic neurones.	Gallamine Triethiodide	187-196	angiotensinogen	Rattus norvegicus	35-49
1761505-5	1991	At high vascular tone, pirenzepine or gallamine attenuated the ACh-induced increase in Rds, whereas Rus was not affected.	Gallamine Triethiodide	38-47	peripherin 2	Canis lupus familiaris	87-90
8099499-1	1993	Influence of inorganic salts on the interaction of cobra venom acetylcholinesterase (EC 3.1.1.7) with hexamethonium and gallamine has been studied.	Gallamine Triethiodide	120-129	acetylcholinesterase (Cartwright blood group)	Homo sapiens	63-83
8099499-3	1993	The ZL psi+Z values for the complex formation between native acetylcholinesterase and hexamethonium (ZL = +2) or gallamine (ZL = +3) were in quantitative agreement with those predicted by the theory making use of psi+1 = 0.50 found earlier from the influence of salts upon the hydrolysis of acetylcholine by the enzyme.	Gallamine Triethiodide	113-122	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-81
1331353-19	1992	Intravenous administration of gallamine triethiodide (Flaxedil), a K+ channel blocker, either induced activity in previously silent fibers or increased the frequency of spontaneous activity in 50% (21/42) of A beta fibers and 19% (3/16) of A delta fibers.	Gallamine Triethiodide	30-52	amyloid beta precursor protein	Rattus norvegicus	208-214
1331353-19	1992	Intravenous administration of gallamine triethiodide (Flaxedil), a K+ channel blocker, either induced activity in previously silent fibers or increased the frequency of spontaneous activity in 50% (21/42) of A beta fibers and 19% (3/16) of A delta fibers.	Gallamine Triethiodide	54-62	amyloid beta precursor protein	Rattus norvegicus	208-214
1761505-7	1991	The pA2 values (i.e., the negative log antagonist concentration requiring a doubling of ACh dose for an equivalent increase in Rds) for gallamine, pirenzepine, secoverine, and atropine were 6.1 +/- 0.1, 7.4 +/- 0.1, 8.3 +/- 0.2, and 10.2 +/- 0.3, respectively.	Gallamine Triethiodide	136-145	peripherin 2	Canis lupus familiaris	127-130
6277402-5	1982	In the case of gallamine, where a dual effect on INa is evident, although both processes were D2O sensitive, only the occlusion phase had a significant temperature dependence.	Gallamine Triethiodide	15-24	internexin neuronal intermediate filament protein alpha	Homo sapiens	49-52
2375989-5	1990	Low concentrations of the M2-selective antagonist gallamine increased phosphoinositide turnover, which is thought to be an M1 postsynaptic response in the forebrain, in brain slices by a Ca2(+)-dependent mechanism.	Gallamine Triethiodide	50-59	carbonic anhydrase 2	Rattus norvegicus	187-190
4083176-1	1985	On the basis of previous findings that histamine-N-methyltransferase (HMT) activity can be significantly enhanced or inhibited by a number of analogues of histamine and drugs containing dialkylaminoalkyl moieties, we investigated whether the neuromuscular blocking drugs alcuronium, d-tubocurarine, decamethonium, succinylcholine, gallamine and pancuronium each of which contain quaternary ammonium groups, influence the activity of HMT.	Gallamine Triethiodide	331-340	histamine N-methyltransferase	Homo sapiens	39-68
4083176-1	1985	On the basis of previous findings that histamine-N-methyltransferase (HMT) activity can be significantly enhanced or inhibited by a number of analogues of histamine and drugs containing dialkylaminoalkyl moieties, we investigated whether the neuromuscular blocking drugs alcuronium, d-tubocurarine, decamethonium, succinylcholine, gallamine and pancuronium each of which contain quaternary ammonium groups, influence the activity of HMT.	Gallamine Triethiodide	331-340	histamine N-methyltransferase	Homo sapiens	70-73
20504464-1	1989	Gallamine and tubocurarine increased the rate of decarbamylation of carbamylated Triton-solubilized rabbit brain acetylcholinesterase and interacted synergistically with 3,3-dimethyl-1-butanol in the acceleration of decarbamylation at low ionic strength.	Gallamine Triethiodide	0-9	ACE-1	Oryctolagus cuniculus	113-133
20504464-6	1989	Gallamine increased the rate of carbamylation of acetylcholinesterase by physostigmine and neostigmine at low ionic strength; however the data were not consistent with a simple model of complexing inhibition by these carbamates.	Gallamine Triethiodide	0-9	ACE-1	Oryctolagus cuniculus	49-69
20504464-7	1989	Overall, the kinetic properties of Triton-solubilized rabbit brain acetylcholinesterase were less sensitive to modification by proposed allosteric effectors than bovine erythrocyte acetylcholinesterase, the allosteric properties of which have been reported previously, and millimolar concentrations of gallamine and tubocurarine were required to produce observable effects at physiological ionic strength.	Gallamine Triethiodide	302-311	ACE-1	Oryctolagus cuniculus	67-87
20487840-0	1981	Gallamine and tubocurarine as possible allosteric modifiers of soluble acetylcholinesterase activity at physiological ionic strength.	Gallamine Triethiodide	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-91
20487840-6	1981	Gallamine, d-tubocurarine and alcuronium accelerated reactivation of dimethylcarbamyl-acetylcholinesterase.	Gallamine Triethiodide	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	86-106
20487840-8	1981	Gallamine and tubocurarine retarded ageing of isopropylmethylphosphonyl-acetylcholinesterase, whereas 3,3-dimethyl-1-butanol had no effect.	Gallamine Triethiodide	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-92
23449734-10	2013	The synergistic effects of methacholine on TGF-beta1-induced proliferation were reduced by the long-acting muscarinic receptor antagonist tiotropium and the M2 receptor subtype-selective antagonist gallamine, but not the M3-selective antagonist DAU5884.	Gallamine Triethiodide	198-207	transforming growth factor beta 1	Homo sapiens	43-52
7398650-6	1980	The reconstitution process impaired the allosteric transition of acetylcholinesterase which is thought to occur when Flaxedil (gallamine triethiodide) is present in a low ionic strength medium.	Gallamine Triethiodide	117-125	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-85
7398650-6	1980	The reconstitution process impaired the allosteric transition of acetylcholinesterase which is thought to occur when Flaxedil (gallamine triethiodide) is present in a low ionic strength medium.	Gallamine Triethiodide	127-149	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-85
24538938-0	1950	Gallamine triethiodide (flaxedil) as an aid to general anaesthesia.	Gallamine Triethiodide	0-22	activation induced cytidine deaminase	Homo sapiens	40-43
24538938-0	1950	Gallamine triethiodide (flaxedil) as an aid to general anaesthesia.	Gallamine Triethiodide	24-32	activation induced cytidine deaminase	Homo sapiens	40-43
4655267-10	1972	Gallamine only slightly reduced the effect of bradykinin.4.	Gallamine Triethiodide	0-9	kininogen 1	Homo sapiens	46-56
19873643-2	1969	AChE strongly binds in vitro effectors of the electroplax: agonists e.g., decamethonium or antagonists, e.g., d-tubocurarine and flaxedil.	Gallamine Triethiodide	129-137	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-4
30213802-1	2018	Muscarinic acetylcholine receptors (mAChRs) are exemplar models for understanding G protein-coupled receptor (GPCR) allostery, possessing a "common" allosteric site in an extracellular vestibule (ECV) for synthetic modulators including gallamine, strychnine, and brucine.	Gallamine Triethiodide	236-245	C-X-C motif chemokine receptor 6	Homo sapiens	82-108
30213802-1	2018	Muscarinic acetylcholine receptors (mAChRs) are exemplar models for understanding G protein-coupled receptor (GPCR) allostery, possessing a "common" allosteric site in an extracellular vestibule (ECV) for synthetic modulators including gallamine, strychnine, and brucine.	Gallamine Triethiodide	236-245	C-X-C motif chemokine receptor 6	Homo sapiens	110-114
28852920-6	2018	Inhibition of esterase activity without altering the AAA activity using gallamine significantly increased the level ALP activity and expression of differentiation-associated genes (p < 0.05), thus favouring mineralization.	Gallamine Triethiodide	72-81	alkaline phosphatase, placental	Homo sapiens	116-119
21971158-9	2011	Pretreatment with the muscarinic (M) 3 receptor antagonist, 1-1-dimethyl-4-diphenylacetoxypiperidinium iodide (500 mug/kg, iv), also decreased the GLP-1 area under curve, by 48 +- 8% (P < 0.05), whereas the antagonists pirenzepine (M1) and gallamine (M2) had no effect.	Gallamine Triethiodide	243-252	glucagon like peptide 1 receptor	Homo sapiens	147-152