PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35208951-5	2022	Further in vitro studies confirmed that mannose-, trehalose- and raffinose-treated LBP completely inhibited the hemagglutination ability towards rat red blood cells.	Trehalose	50-59	lipopolysaccharide binding protein	Rattus norvegicus	83-86
35508907-7	2022	According to the dynamic light scattering data, trehalose affects the nucleation stage of Phb thermal aggregation at 48 C, and an increase in the alphaB-Cr adsorption capacity (AC0) is the main effect of trehalose on the aggregation process in the presence of the protein chaperone (AC0 increases 1.5-fold in the presence of 66 mM trehalose).	Trehalose	48-57	prohibitin 1	Homo sapiens	90-93
35508907-7	2022	According to the dynamic light scattering data, trehalose affects the nucleation stage of Phb thermal aggregation at 48 C, and an increase in the alphaB-Cr adsorption capacity (AC0) is the main effect of trehalose on the aggregation process in the presence of the protein chaperone (AC0 increases 1.5-fold in the presence of 66 mM trehalose).	Trehalose	48-57	ATP binding cassette subfamily A member 4	Homo sapiens	146-155
35508907-6	2022	We have studied the trehalose effect on the quaternary structure and anti-aggregation activity of alphaB-Cr using muscle glycogen phosphorylase b (Phb) as a target protein.	Trehalose	20-29	ATP binding cassette subfamily A member 4	Homo sapiens	98-107
35508907-7	2022	According to the dynamic light scattering data, trehalose affects the nucleation stage of Phb thermal aggregation at 48 C, and an increase in the alphaB-Cr adsorption capacity (AC0) is the main effect of trehalose on the aggregation process in the presence of the protein chaperone (AC0 increases 1.5-fold in the presence of 66 mM trehalose).	Trehalose	204-213	prohibitin 1	Homo sapiens	90-93
35508907-7	2022	According to the dynamic light scattering data, trehalose affects the nucleation stage of Phb thermal aggregation at 48 C, and an increase in the alphaB-Cr adsorption capacity (AC0) is the main effect of trehalose on the aggregation process in the presence of the protein chaperone (AC0 increases 1.5-fold in the presence of 66 mM trehalose).	Trehalose	204-213	ATP binding cassette subfamily A member 4	Homo sapiens	146-155
35508907-7	2022	According to the dynamic light scattering data, trehalose affects the nucleation stage of Phb thermal aggregation at 48 C, and an increase in the alphaB-Cr adsorption capacity (AC0) is the main effect of trehalose on the aggregation process in the presence of the protein chaperone (AC0 increases 1.5-fold in the presence of 66 mM trehalose).	Trehalose	331-340	prohibitin 1	Homo sapiens	90-93
35508907-7	2022	According to the dynamic light scattering data, trehalose affects the nucleation stage of Phb thermal aggregation at 48 C, and an increase in the alphaB-Cr adsorption capacity (AC0) is the main effect of trehalose on the aggregation process in the presence of the protein chaperone (AC0 increases 1.5-fold in the presence of 66 mM trehalose).	Trehalose	331-340	ATP binding cassette subfamily A member 4	Homo sapiens	146-155
35508907-8	2022	According to the sedimentation analysis data, trehalose stabilizes the dimeric form of Phb at the stages of denaturation and dissociation and enhances the interaction of alphaB-Cr with the target protein.	Trehalose	46-55	prohibitin 1	Homo sapiens	87-90
35508907-8	2022	According to the sedimentation analysis data, trehalose stabilizes the dimeric form of Phb at the stages of denaturation and dissociation and enhances the interaction of alphaB-Cr with the target protein.	Trehalose	46-55	ATP binding cassette subfamily A member 4	Homo sapiens	170-179
35508907-9	2022	Moreover, trehalose shifts the equilibrium between the alphaB-Cr oligomers towards the smaller forms.	Trehalose	10-19	ATP binding cassette subfamily A member 4	Homo sapiens	55-64
35508907-10	2022	Thus, trehalose affects the quaternary structure of alphaB-Cr and increases its anti-aggregation activity at the nucleation stage.	Trehalose	6-15	ATP binding cassette subfamily A member 4	Homo sapiens	52-61
35279962-1	2022	At cold temperatures, trehalose can be used to substitute water, inhibit the solid-liquid transition phase of the PLT membrane, and stop Glycoprotein Ibalpha (GPIbalpha) polymerization.	Trehalose	22-31	glycoprotein Ib platelet subunit alpha	Homo sapiens	137-157
35279962-1	2022	At cold temperatures, trehalose can be used to substitute water, inhibit the solid-liquid transition phase of the PLT membrane, and stop Glycoprotein Ibalpha (GPIbalpha) polymerization.	Trehalose	22-31	glycoprotein Ib platelet subunit alpha	Homo sapiens	159-168
35279962-10	2022	The highest increase in the amount of caspase-3 levels in the PLTs was observed at 4 C. However, trehalose-treated and 4 C PLTs had a lower amount of active caspase-3 in comparison with 4 C PLTs.	Trehalose	97-106	caspase 3	Homo sapiens	38-47
35279962-10	2022	The highest increase in the amount of caspase-3 levels in the PLTs was observed at 4 C. However, trehalose-treated and 4 C PLTs had a lower amount of active caspase-3 in comparison with 4 C PLTs.	Trehalose	97-106	caspase 3	Homo sapiens	157-166
2619709-1	1989	Trehalase is an enzyme which hydrolyzes the disaccharide trehalose, yielding glucose.	Trehalose	57-66	trehalase	Homo sapiens	0-9
35053361-4	2022	Furthermore, daf-2 mutants show increased abundance of the group 3 late embryogenesis abundant protein LEA-1, which has been found to act in synergy with trehalose to exert its protective role against desiccation and heat stress in vitro, and to be essential for desiccation tolerance in C. elegans dauer larvae.	Trehalose	154-163	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	13-18
35053361-4	2022	Furthermore, daf-2 mutants show increased abundance of the group 3 late embryogenesis abundant protein LEA-1, which has been found to act in synergy with trehalose to exert its protective role against desiccation and heat stress in vitro, and to be essential for desiccation tolerance in C. elegans dauer larvae.	Trehalose	154-163	plant Late Embryo Abundant (LEA) related	Caenorhabditis elegans	103-108
35129134-5	2022	Lilli knockdown adult females had significantly higher haemolymph trehalose and glucose levels, while dilp2, which plays a major role in sugar metabolism, was downregulated.	Trehalose	66-75	lilliputian	Drosophila melanogaster	0-5
35011993-12	2022	CONCLUSIONS: Positive trends in health-related quality of life (HRQoL), serum biomarkers, and organomegaly were observed after 3 months of treatment with trehalose in patients with NPA and NPB.	Trehalose	154-163	neuropeptide B	Homo sapiens	189-192
2620297-0	1989	Steric course of the hydrolysis of alpha,alpha-trehalose and alpha-D-glucosyl fluoride catalyzed by pig kidney trehalase.	Trehalose	35-56	trehalase	Sus scrofa	111-120
2620297-1	1989	We are unable to confirm the report of Labat et al.3 that pig kidney trehalase hydrolyzes alpha,alpha-trehalose to form solely alpha-D-glucose.	Trehalose	90-111	trehalase	Sus scrofa	69-78
2620297-5	1989	Present results show the stereochemical behavior of pig kidney trehalase in hydrolyzing alpha,alpha-trehalose to be indistinguishable from that reported by ourselves and others for trehalase preparations from a range of biological sources including rabbit renal cortex.	Trehalose	88-109	trehalase	Sus scrofa	63-72
3227291-2	1988	Trehalose tolerance tests performed in three individuals with low trehalase activity (6 IU/g protein) showed no increase in the blood glucose concentration.	Trehalose	0-9	trehalase	Homo sapiens	66-75
2526652-2	1989	Freeze-drying of trehalose, lactose, and myo-inositol with lysozyme resulted in substantial alterations of the infrared spectra of the dried carbohydrates.	Trehalose	17-26	lysozyme C-like	Oryctolagus cuniculus	59-67
2526652-6	1989	In complementary experiments, it was found that dehydration-induced shifts in the positions of amide I and amide II bands for lysozyme could be partially and fully reversed, respectively, when the protein was freeze-dried in the presence of either trehalose or lactose.	Trehalose	248-257	lysozyme C-like	Oryctolagus cuniculus	126-134
2946263-10	1986	The addition of ionic copper, cadmium, nickel, and cobalt to trehalose-PFK solutions prior to freezing also increases the percentage of activity recovered after thawing.	Trehalose	61-70	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	71-74
17246428-1	1988	The taste sensitivity to the disaccharide trehalose of Drosophila melanogaster is under the genetic control by the Tre gene on the X chromosome.	Trehalose	42-51	tre	Drosophila melanogaster	115-118
17246428-3	1988	We have determined the cytological localization of the Tre gene to be between 5A10 and 5B1-3 by analyzing the sensitivity to trehalose in flies which are segmentally aneuploid bearing either deficiencies or duplicated fragments of T(X;Y) translocations.	Trehalose	125-134	tre	Drosophila melanogaster	55-58
17246428-5	1988	Trehalose sensitivity decreased in females carrying half the normal dosage of a given Tre allele, but a proportional increase in sensitivity was not observed in flies bearing a duplication of the Tre alleles.	Trehalose	0-9	tre	Drosophila melanogaster	86-89
2958239-7	1987	The addition of ionic copper, cobalt, or nickel to trehalose-PFK solution prior to rapid drying results in a large increase in the activity recovered, and the presence of cadmium or manganese leads to a minor increase.	Trehalose	51-60	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	61-64
3159619-4	1985	We suggest that the mutant subunits act as inhibitors by entering into the multimeric forms of the enzyme and altering the ability of the normal wild-type subunits to catalyze the cleavage of trehalose.--Wild type trehalase has been purified to near homogeneity, and its characteristics have been studied.	Trehalose	192-201	trehalase	Homo sapiens	214-223
6296049-1	1983	Mutation at the GLC1 locus in Saccharomyces cerevisiae resulted in simultaneous deficiencies in glycogen and trehalose accumulation.	Trehalose	109-118	GTPase-activating protein IRA1	Saccharomyces cerevisiae S288C	16-20
2942205-0	1985	Investigation of the relationship between sst1 and fdp mutations in yeast and their effect on trehalose synthesis.	Trehalose	94-103	aspartyl protease BAR1	Saccharomyces cerevisiae S288C	42-46
18620141-8	1985	These results suggest that midgut trehalase plays a physiological role in utilization of haemolymph trehalose not in nutrient absorption.	Trehalose	100-109	trehalase	Bombyx mori	34-43
6498204-1	1984	Phlorizin, phloretin, Tris and beta-methylglucoside are competitive inhibitors, with respect to the substrate trehalose, of purified renal trehalase.	Trehalose	110-119	trehalase	Homo sapiens	139-148
7104311-1	1982	A new understanding has been obtained of the catalytic capabilities of trehalase, an enzyme heretofore held to be strictly specific for hydrolyzing alpha, alpha-trehalose and devoid of transglycosylative ability.	Trehalose	155-170	trehalase	Oryctolagus cuniculus	71-80
7104311-5	1982	In addition, digests of beta-D-glucosyl fluoride plus alpha-D-[14C]-glucopyranose with either trehalase (but not controls of enzyme with alpha-D-[14C]glucopyranose alone) yielded small amounts of radioactive trehalose (alpha-D-glucopyranosyl alpha-D-[14C]glucopyranoside) which does not accumulate since it is rapidly hydrolyzed.	Trehalose	208-217	trehalase	Oryctolagus cuniculus	94-103
7104311-6	1982	Trehalase thus catalyzes two stereocomplementary types of glycosylation reactions: (I) alpha-D-glucosyl fluoride (or alpha, alpha-trehalose) + H2O leads to beta-D-glucose + HF (or alpha-D-glucose); (II) beta-D-glucosyl fluoride + alpha-D-glucopyranose leads to alpha, alpha-trehalose + HF.	Trehalose	122-139	trehalase	Oryctolagus cuniculus	0-9
7104311-6	1982	Trehalase thus catalyzes two stereocomplementary types of glycosylation reactions: (I) alpha-D-glucosyl fluoride (or alpha, alpha-trehalose) + H2O leads to beta-D-glucose + HF (or alpha-D-glucose); (II) beta-D-glucosyl fluoride + alpha-D-glucopyranose leads to alpha, alpha-trehalose + HF.	Trehalose	266-283	trehalase	Oryctolagus cuniculus	0-9
7137952-4	1982	The single-cell proteins may contain trehalose, the absorption of which by the human intestine necessitates prior hydrolysis by trehalase, a specific brush-border disaccharidase.	Trehalose	37-46	trehalase	Homo sapiens	128-137
24186091-4	1982	However, sst1 strains still exhibited trehalose accumulation during growth on maltose medium, provided they contained a gene for maltose fermentation (MAL gene).	Trehalose	38-47	aspartyl protease BAR1	Saccharomyces cerevisiae S288C	9-13
24186091-5	1982	Introduction of a constitutive MAL (c) gene into an sst1 strain rendered the strain capable of accumulating trehalose during growth on glucose medium, but did not restore the normal capacity to convert glucose to trehalose in nonproliferating conditions.	Trehalose	108-117	aspartyl protease BAR1	Saccharomyces cerevisiae S288C	52-56
24186091-8	1982	It is unlikely that system II produces trehalose by trans-glucosylation, since it converted glucose to trehalose in MAL (c) sst1 strains.	Trehalose	103-112	aspartyl protease BAR1	Saccharomyces cerevisiae S288C	124-128
6176218-6	1982	The hydrolysis of maltose, trehalose and melezitose confirmed the presence of alpha-glucosidase activity.	Trehalose	27-36	sucrase-isomaltase	Homo sapiens	78-95
7137952-5	1982	The enzymatic analysis of 100 intestinal biopsies discovered 2 cases of very low trehalase level, with an expected clinical intolerance to even small doses of trehalose.	Trehalose	159-168	trehalase	Homo sapiens	81-90
6973543-1	1981	Cord factor--a mixture of 6,6"-diesters of alpha, alpha-D-trehalose with natural mycolic acids--which is purified from mycobacteria and other microorganisms, is known to have adjuvant activity as well as to enhance nonspecific resistance to infections and tumor development.	Trehalose	43-67	general transcription factor III A	Rattus norvegicus	5-14
24185867-2	1981	Three independent glc1 mutations were shown to have the same pleiotropic phenotype: catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation.	Trehalose	150-159	GTPase-activating protein IRA1	Saccharomyces cerevisiae S288C	18-22
7045582-7	1982	Constructed strains containing both glc1 and the constitutive maltose fermentation gene MAL4c can accumulate trehalose but not glycogen during growth on glucose.	Trehalose	109-118	GTPase-activating protein IRA1	Saccharomyces cerevisiae S288C	36-40
7341233-0	1980	Stereochemistry of the hydrolysis of trehalose by the enzyme trehalase prepared from the flesh fly Sarcophaga barbata.	Trehalose	37-46	Trehalase	Drosophila melanogaster	61-70
7341233-10	1980	It was found that an equimolar mixture of alpha-D-glucose and beta-D-glucose is formed on hydrolysis of trehalose by trehalase and 18O is incorporated into beta-D-glucose.	Trehalose	104-113	Trehalase	Drosophila melanogaster	117-126
299770-0	1977	Trehalose covalently conjugated to bovine serum albumin.	Trehalose	0-9	albumin	Homo sapiens	42-55
7435208-1	1980	Total sugar content with a higher level than glucose and trehalose presents a sharp increase in the late days of embryonic development in the eri-silkworm, whereas glucose and trehalose levels correspond to trehalase activity which increase in the early and late days associated with an intensive synthetic activity.	Trehalose	176-185	trehalase	Bombyx mori	207-216
352926-4	1978	Two lower synthetic 6,6"-diesters of trehalose with C22 acids, which are described here for the first time, as well as dipalmitate and a dioleate of sucrose, were found inactive.	Trehalose	37-46	Sp7 transcription factor 7	Mus musculus	52-55
896090-3	1977	Maltose, trehalose, sucrose, and turanose refeeding resulted in G6PD and ME responses which were higher than the responses to their component monosaccharides (disaccharide effect).	Trehalose	9-18	glucose-6-phosphate dehydrogenase	Rattus norvegicus	64-68
615463-1	1977	Trehalase (an enzyme decomposing the disaccharide trehalose) activity was studied in 29 healthy subjects, 25 patients with cirrhosis and 112 diabetics.	Trehalose	50-59	trehalase	Homo sapiens	0-9
809164-0	1975	[Influence of parenteral injection of trehalose on mammals with different trehalase levels].	Trehalose	38-47	trehalase	Oryctolagus cuniculus	74-83
1211677-0	1975	[Influence of parenterally injected trehalose in mammals having trehalase activity at different sites].	Trehalose	36-45	trehalase	Oryctolagus cuniculus	64-73
32428381-0	2021	Inhibition of trehalase affects the trehalose and chitin metabolism pathways in Diaphorina citri (Hemiptera: Psyllidae).	Trehalose	36-45	trehalase	Diaphorina citri	14-23
4269377-5	1973	Therefore, it is most probable that in dormant ascospores of Neurospora, trehalase, and its substrate, trehalose, are physically separated.	Trehalose	103-112	trehalase	Homo sapiens	73-82
5663295-2	1968	The specific localization of the enzyme supports the hypothesis that trehalase, in concert with a series of other enzymes which synthesize trehalose from glucose, functions in a mechanism for the reabsorption of glucose from the glomerular filtrate.	Trehalose	139-148	trehalase	Homo sapiens	69-78
33960273-8	2021	In addition, exogenous trehalose decreased the transcriptional levels of CycD2 and CDC2 (two genes regulating cell cycle progression) under heat stress, and reduced the activity of vacuolar invertase after recovery from heat stress, thereby shortening the cell length.	Trehalose	23-32	cyclin dependent kinase 1	Homo sapiens	83-87
33960273-9	2021	These results indicate that trehalose inhibits wheat growth at high temperature by affecting plant hormone levels and the cell cycle process.AbbreviationsABA, abscisic acid; CDK, cyclin-dependent kinase; CycD, D-type cyclins; GA3, gibberellin; IAA, auxin; KRP, KIP-related protein; T6P, trehalsoe-6-phosphate; VIN, vacuolar invertase.	Trehalose	28-37	myosin light chain kinase	Homo sapiens	256-259
33960273-9	2021	These results indicate that trehalose inhibits wheat growth at high temperature by affecting plant hormone levels and the cell cycle process.AbbreviationsABA, abscisic acid; CDK, cyclin-dependent kinase; CycD, D-type cyclins; GA3, gibberellin; IAA, auxin; KRP, KIP-related protein; T6P, trehalsoe-6-phosphate; VIN, vacuolar invertase.	Trehalose	28-37	long intergenic non-protein coding RNA 1191	Homo sapiens	310-313
32428381-2	2021	Trehalase is a key enzyme involved in trehalose hydrolysis and plays an important role in insect growth and development.	Trehalose	38-47	trehalase	Diaphorina citri	0-9
33417959-6	2021	Trehalose possessing an antioxidant activity also has effect on cancer, which is explained through targeting cell progression, angiogenesis and metastasis pathways at molecular level targeting EGFR, PI3K, Akt, VEGF and MMP 9 proteins inside the cell.	Trehalose	0-9	epidermal growth factor receptor	Homo sapiens	193-197
33881737-4	2021	RESULTS: The sugars mannitol, sucrose and trehalose, and the amino acids Arg, Lys, and His significantly promote the oxidation of peptide Met to peptide Met sulfoxide.	Trehalose	42-51	SAFB like transcription modulator	Homo sapiens	138-141
33881737-4	2021	RESULTS: The sugars mannitol, sucrose and trehalose, and the amino acids Arg, Lys, and His significantly promote the oxidation of peptide Met to peptide Met sulfoxide.	Trehalose	42-51	SAFB like transcription modulator	Homo sapiens	153-156
33417959-6	2021	Trehalose possessing an antioxidant activity also has effect on cancer, which is explained through targeting cell progression, angiogenesis and metastasis pathways at molecular level targeting EGFR, PI3K, Akt, VEGF and MMP 9 proteins inside the cell.	Trehalose	0-9	AKT serine/threonine kinase 1	Homo sapiens	205-208
33417959-6	2021	Trehalose possessing an antioxidant activity also has effect on cancer, which is explained through targeting cell progression, angiogenesis and metastasis pathways at molecular level targeting EGFR, PI3K, Akt, VEGF and MMP 9 proteins inside the cell.	Trehalose	0-9	vascular endothelial growth factor A	Homo sapiens	210-214
33417959-6	2021	Trehalose possessing an antioxidant activity also has effect on cancer, which is explained through targeting cell progression, angiogenesis and metastasis pathways at molecular level targeting EGFR, PI3K, Akt, VEGF and MMP 9 proteins inside the cell.	Trehalose	0-9	matrix metallopeptidase 9	Homo sapiens	219-224
33478058-6	2021	As expected, AMPK overexpression in homozygous transgenic mosquitoes was associated with changes in nutrient storage and metabolism, decreasing glycogen levels at 24 h post-blood feeding when transgene expression was maximal, and concurrently increasing circulating trehalose at the same time point.	Trehalose	266-275	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	13-17
33706671-0	2021	Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response.	Trehalose	0-9	transcription factor EB	Homo sapiens	56-60
33706671-11	2021	Taken together, our data show the trehalose can act as a weak inhibitor of the lysosome which serves as a trigger for TFEB activation.	Trehalose	34-43	transcription factor EB	Homo sapiens	118-122
33197516-0	2021	Trehalose protects motorneuron after brachial plexus root avulsion by activating autophagy and inhibiting apoptosis mediated by the AMPK signaling pathway.	Trehalose	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	132-136
33197516-7	2021	Moreover, in TBHP-treated NSC34 cells, trehalose promoted the expression of autophage-related markers (LC3 and Beclin-1), concomitant with decreased levels of apoptosis.	Trehalose	39-48	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	103-106
33197516-7	2021	Moreover, in TBHP-treated NSC34 cells, trehalose promoted the expression of autophage-related markers (LC3 and Beclin-1), concomitant with decreased levels of apoptosis.	Trehalose	39-48	beclin 1, autophagy related	Mus musculus	111-119
33197516-8	2021	In vitro mechanism study indicated that the regulations of trehalose on autophage and apoptosis were via the AMPK-ULK1 pathway.Trehalose protects injured MNs by enhancing autophage and inhibiting apoptosis, which demonstrating the essential role of trehalose in the prevention and treatment of BPRA.	Trehalose	59-68	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	109-113
33197516-8	2021	In vitro mechanism study indicated that the regulations of trehalose on autophage and apoptosis were via the AMPK-ULK1 pathway.Trehalose protects injured MNs by enhancing autophage and inhibiting apoptosis, which demonstrating the essential role of trehalose in the prevention and treatment of BPRA.	Trehalose	59-68	unc-51 like autophagy activating kinase 1	Rattus norvegicus	114-118
33197516-8	2021	In vitro mechanism study indicated that the regulations of trehalose on autophage and apoptosis were via the AMPK-ULK1 pathway.Trehalose protects injured MNs by enhancing autophage and inhibiting apoptosis, which demonstrating the essential role of trehalose in the prevention and treatment of BPRA.	Trehalose	127-136	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	109-113
33197516-8	2021	In vitro mechanism study indicated that the regulations of trehalose on autophage and apoptosis were via the AMPK-ULK1 pathway.Trehalose protects injured MNs by enhancing autophage and inhibiting apoptosis, which demonstrating the essential role of trehalose in the prevention and treatment of BPRA.	Trehalose	127-136	unc-51 like autophagy activating kinase 1	Rattus norvegicus	114-118
33197516-8	2021	In vitro mechanism study indicated that the regulations of trehalose on autophage and apoptosis were via the AMPK-ULK1 pathway.Trehalose protects injured MNs by enhancing autophage and inhibiting apoptosis, which demonstrating the essential role of trehalose in the prevention and treatment of BPRA.	Trehalose	249-258	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	109-113
33632046-6	2021	Oxidant-antioxidant markers were assessed using ELISA and colorimetric procedures.Results: The results revealed that trehalose significantly mitigated the effect of LPS on the phosphorylation of JNK and NF-kappaB-P65 (p < .00).	Trehalose	117-126	mitogen-activated protein kinase 8	Homo sapiens	195-198
33632046-6	2021	Oxidant-antioxidant markers were assessed using ELISA and colorimetric procedures.Results: The results revealed that trehalose significantly mitigated the effect of LPS on the phosphorylation of JNK and NF-kappaB-P65 (p < .00).	Trehalose	117-126	RELA proto-oncogene, NF-kB subunit	Homo sapiens	203-216
33632046-9	2021	Furthermore, trehalose alleviated oxidative stress in LPS-stimulated PBMCs as it reversed the altered levels of malondialdehyde and total thiols (p <= .05) and restored the activity of antioxidant enzymes glutathione peroxidase and manganese superoxide dismutase (p < .001).Conclusion: The results of this study indicated that trehalose prevented inflammation and oxidative stress in the LPS-stimulated PBMCs, providing evidence for the benefits of trehalose as a potential therapeutic agent in inflammatory conditions.Abbreviations: LPS: Lipopolysaccharide; NAC: N-Acetyl cysteine; ROS: Reactive oxygen species; IL-6: Interleukin-6; TNF-alpha: Tumor necrosis factor-alpha; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; MDA: Malondialdehyde; MAPK: Mitogen-activated protein kinases; JNK: c-Jun N-terminal kinase; NF-kappaB: Nuclear factor kappa-light-chain-enhancer of activated B cells.	Trehalose	13-22	superoxide dismutase 2	Homo sapiens	232-262
33632046-9	2021	Furthermore, trehalose alleviated oxidative stress in LPS-stimulated PBMCs as it reversed the altered levels of malondialdehyde and total thiols (p <= .05) and restored the activity of antioxidant enzymes glutathione peroxidase and manganese superoxide dismutase (p < .001).Conclusion: The results of this study indicated that trehalose prevented inflammation and oxidative stress in the LPS-stimulated PBMCs, providing evidence for the benefits of trehalose as a potential therapeutic agent in inflammatory conditions.Abbreviations: LPS: Lipopolysaccharide; NAC: N-Acetyl cysteine; ROS: Reactive oxygen species; IL-6: Interleukin-6; TNF-alpha: Tumor necrosis factor-alpha; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; MDA: Malondialdehyde; MAPK: Mitogen-activated protein kinases; JNK: c-Jun N-terminal kinase; NF-kappaB: Nuclear factor kappa-light-chain-enhancer of activated B cells.	Trehalose	13-22	interleukin 6	Homo sapiens	613-617
33632046-9	2021	Furthermore, trehalose alleviated oxidative stress in LPS-stimulated PBMCs as it reversed the altered levels of malondialdehyde and total thiols (p <= .05) and restored the activity of antioxidant enzymes glutathione peroxidase and manganese superoxide dismutase (p < .001).Conclusion: The results of this study indicated that trehalose prevented inflammation and oxidative stress in the LPS-stimulated PBMCs, providing evidence for the benefits of trehalose as a potential therapeutic agent in inflammatory conditions.Abbreviations: LPS: Lipopolysaccharide; NAC: N-Acetyl cysteine; ROS: Reactive oxygen species; IL-6: Interleukin-6; TNF-alpha: Tumor necrosis factor-alpha; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; MDA: Malondialdehyde; MAPK: Mitogen-activated protein kinases; JNK: c-Jun N-terminal kinase; NF-kappaB: Nuclear factor kappa-light-chain-enhancer of activated B cells.	Trehalose	13-22	interleukin 6	Homo sapiens	619-632
33632046-9	2021	Furthermore, trehalose alleviated oxidative stress in LPS-stimulated PBMCs as it reversed the altered levels of malondialdehyde and total thiols (p <= .05) and restored the activity of antioxidant enzymes glutathione peroxidase and manganese superoxide dismutase (p < .001).Conclusion: The results of this study indicated that trehalose prevented inflammation and oxidative stress in the LPS-stimulated PBMCs, providing evidence for the benefits of trehalose as a potential therapeutic agent in inflammatory conditions.Abbreviations: LPS: Lipopolysaccharide; NAC: N-Acetyl cysteine; ROS: Reactive oxygen species; IL-6: Interleukin-6; TNF-alpha: Tumor necrosis factor-alpha; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; MDA: Malondialdehyde; MAPK: Mitogen-activated protein kinases; JNK: c-Jun N-terminal kinase; NF-kappaB: Nuclear factor kappa-light-chain-enhancer of activated B cells.	Trehalose	13-22	tumor necrosis factor	Homo sapiens	634-643
33632046-9	2021	Furthermore, trehalose alleviated oxidative stress in LPS-stimulated PBMCs as it reversed the altered levels of malondialdehyde and total thiols (p <= .05) and restored the activity of antioxidant enzymes glutathione peroxidase and manganese superoxide dismutase (p < .001).Conclusion: The results of this study indicated that trehalose prevented inflammation and oxidative stress in the LPS-stimulated PBMCs, providing evidence for the benefits of trehalose as a potential therapeutic agent in inflammatory conditions.Abbreviations: LPS: Lipopolysaccharide; NAC: N-Acetyl cysteine; ROS: Reactive oxygen species; IL-6: Interleukin-6; TNF-alpha: Tumor necrosis factor-alpha; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; MDA: Malondialdehyde; MAPK: Mitogen-activated protein kinases; JNK: c-Jun N-terminal kinase; NF-kappaB: Nuclear factor kappa-light-chain-enhancer of activated B cells.	Trehalose	13-22	tumor necrosis factor	Homo sapiens	645-672
33632046-9	2021	Furthermore, trehalose alleviated oxidative stress in LPS-stimulated PBMCs as it reversed the altered levels of malondialdehyde and total thiols (p <= .05) and restored the activity of antioxidant enzymes glutathione peroxidase and manganese superoxide dismutase (p < .001).Conclusion: The results of this study indicated that trehalose prevented inflammation and oxidative stress in the LPS-stimulated PBMCs, providing evidence for the benefits of trehalose as a potential therapeutic agent in inflammatory conditions.Abbreviations: LPS: Lipopolysaccharide; NAC: N-Acetyl cysteine; ROS: Reactive oxygen species; IL-6: Interleukin-6; TNF-alpha: Tumor necrosis factor-alpha; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; MDA: Malondialdehyde; MAPK: Mitogen-activated protein kinases; JNK: c-Jun N-terminal kinase; NF-kappaB: Nuclear factor kappa-light-chain-enhancer of activated B cells.	Trehalose	13-22	superoxide dismutase 1	Homo sapiens	674-677
33632046-9	2021	Furthermore, trehalose alleviated oxidative stress in LPS-stimulated PBMCs as it reversed the altered levels of malondialdehyde and total thiols (p <= .05) and restored the activity of antioxidant enzymes glutathione peroxidase and manganese superoxide dismutase (p < .001).Conclusion: The results of this study indicated that trehalose prevented inflammation and oxidative stress in the LPS-stimulated PBMCs, providing evidence for the benefits of trehalose as a potential therapeutic agent in inflammatory conditions.Abbreviations: LPS: Lipopolysaccharide; NAC: N-Acetyl cysteine; ROS: Reactive oxygen species; IL-6: Interleukin-6; TNF-alpha: Tumor necrosis factor-alpha; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; MDA: Malondialdehyde; MAPK: Mitogen-activated protein kinases; JNK: c-Jun N-terminal kinase; NF-kappaB: Nuclear factor kappa-light-chain-enhancer of activated B cells.	Trehalose	13-22	mitogen-activated protein kinase 8	Homo sapiens	793-796
33632046-9	2021	Furthermore, trehalose alleviated oxidative stress in LPS-stimulated PBMCs as it reversed the altered levels of malondialdehyde and total thiols (p <= .05) and restored the activity of antioxidant enzymes glutathione peroxidase and manganese superoxide dismutase (p < .001).Conclusion: The results of this study indicated that trehalose prevented inflammation and oxidative stress in the LPS-stimulated PBMCs, providing evidence for the benefits of trehalose as a potential therapeutic agent in inflammatory conditions.Abbreviations: LPS: Lipopolysaccharide; NAC: N-Acetyl cysteine; ROS: Reactive oxygen species; IL-6: Interleukin-6; TNF-alpha: Tumor necrosis factor-alpha; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; MDA: Malondialdehyde; MAPK: Mitogen-activated protein kinases; JNK: c-Jun N-terminal kinase; NF-kappaB: Nuclear factor kappa-light-chain-enhancer of activated B cells.	Trehalose	13-22	mitogen-activated protein kinase 8	Homo sapiens	798-821
33632046-9	2021	Furthermore, trehalose alleviated oxidative stress in LPS-stimulated PBMCs as it reversed the altered levels of malondialdehyde and total thiols (p <= .05) and restored the activity of antioxidant enzymes glutathione peroxidase and manganese superoxide dismutase (p < .001).Conclusion: The results of this study indicated that trehalose prevented inflammation and oxidative stress in the LPS-stimulated PBMCs, providing evidence for the benefits of trehalose as a potential therapeutic agent in inflammatory conditions.Abbreviations: LPS: Lipopolysaccharide; NAC: N-Acetyl cysteine; ROS: Reactive oxygen species; IL-6: Interleukin-6; TNF-alpha: Tumor necrosis factor-alpha; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; MDA: Malondialdehyde; MAPK: Mitogen-activated protein kinases; JNK: c-Jun N-terminal kinase; NF-kappaB: Nuclear factor kappa-light-chain-enhancer of activated B cells.	Trehalose	13-22	nuclear factor kappa B subunit 1	Homo sapiens	823-832
33673074-0	2021	Elevated Trehalose Levels in C. elegans daf-2 Mutants Increase Stress Resistance, Not Lifespan.	Trehalose	9-18	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	40-45
33673074-2	2021	Trehalose, a disaccharide of glucose, is highly upregulated in daf-2 mutants and it has been linked to proteome stabilization and protection against heat, cold, desiccation, and hypoxia.	Trehalose	0-9	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	63-68
33673074-3	2021	Earlier studies suggested that elevated trehalose levels can explain up to 43% of the lifespan extension observed in daf-2 mutants.	Trehalose	40-49	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	117-122
33227703-8	2021	Moreover, a pathogenic role of TFEB in adenine-induced CKD was speculated because the pharmacological activation of TFEB by trehalose failed to protect mice from tubulointerstitial injuries.	Trehalose	124-133	transcription factor EB	Mus musculus	116-120
33441844-1	2021	Trehalose-6-phosphate synthase (TPS) and trehalase (TRE) directly regulate trehalose metabolism and indirectly regulate chitin metabolism in insects.	Trehalose	75-84	trehalase	Acyrthosiphon pisum	41-50
33441844-1	2021	Trehalose-6-phosphate synthase (TPS) and trehalase (TRE) directly regulate trehalose metabolism and indirectly regulate chitin metabolism in insects.	Trehalose	75-84	trehalase	Acyrthosiphon pisum	52-55
33227703-9	2021	In the epithelioid clone of normal rat kidney cells (NRK-52E), the activation of TFEB by trehalose increased autophagy induction, cell death and inflammatory cytokine (Interleukin-6, IL-6) release.	Trehalose	89-98	transcription factor EB	Rattus norvegicus	81-85
33227703-9	2021	In the epithelioid clone of normal rat kidney cells (NRK-52E), the activation of TFEB by trehalose increased autophagy induction, cell death and inflammatory cytokine (Interleukin-6, IL-6) release.	Trehalose	89-98	interleukin 6	Rattus norvegicus	168-181
33227703-9	2021	In the epithelioid clone of normal rat kidney cells (NRK-52E), the activation of TFEB by trehalose increased autophagy induction, cell death and inflammatory cytokine (Interleukin-6, IL-6) release.	Trehalose	89-98	interleukin 6	Rattus norvegicus	183-187
33084317-4	2020	Here we report the synthesis and characterization of star polymers consisting of functional trehalose-based macrocyclic cores (cyclotrehalans, CTs) and aminothiourea dendron arms, which can be efficiently synthesized from sequential click reactions of orthogonal monomers, display no cytotoxicity, and efficiently complex and deliver plasmid DNA in vitro and in vivo.	Trehalose	92-101	steroidogenic acute regulatory protein	Homo sapiens	53-57
33226392-0	2020	Involvement of Nrf2 and mitochondrial apoptotic signaling in trehalose protection against cadmium-induced kidney injury.	Trehalose	61-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	15-19
33317300-1	2020	We study, with molecular dynamics simulations, a lysozyme protein immersed in a water-trehalose solution upon cooling.	Trehalose	86-95	lysozyme	Homo sapiens	49-57
33319329-8	2020	The process was further translated to produce powders of glucagon and glucagon-trehalose formulations with yields of >83.24%.	Trehalose	79-88	glucagon	Homo sapiens	70-78
33277792-0	2021	Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes.	Trehalose	0-9	sequestosome 1	Homo sapiens	18-24
33277792-0	2021	Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes.	Trehalose	0-9	sequestosome 1	Homo sapiens	25-28
33277792-4	2021	We recently revealed that trehalose increases SQSTM1 levels and enhances antioxidative capacity in hepatocytes.	Trehalose	26-35	sequestosome 1	Homo sapiens	46-52
33277792-6	2021	We initially confirmed that trehalose increases SQSTM1 transcription and protein levels without affecting autophagy in adipocytes.	Trehalose	28-37	sequestosome 1	Homo sapiens	48-54
33277792-7	2021	Trehalose also elevated transcription of several lysosomal genes and the activity of cathepsin L, a lysosomal enzyme, independently of the transcription factor EB.	Trehalose	0-9	cathepsin L	Homo sapiens	85-96
33277792-8	2021	In agreement with our data from hepatocytes, trehalose induced the nuclear translocation of NRF2 and the transcription of its downstream antioxidative genes, resulting in reduced cellular reactive oxygen species levels.	Trehalose	45-54	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
33364490-4	2020	In addition, we previously demonstrated that recombinant RpL10a from Fenneropenaeus merguiensis (Fm-RpL10a) could stimulate cell proliferation and trehalose metabolism in RpL10a-over-expressing flies by inducing insulin receptor (InR) expression and some insulin signaling mediators phosphorylation.	Trehalose	147-156	ribosomal protein L10a	Homo sapiens	57-63
33364490-4	2020	In addition, we previously demonstrated that recombinant RpL10a from Fenneropenaeus merguiensis (Fm-RpL10a) could stimulate cell proliferation and trehalose metabolism in RpL10a-over-expressing flies by inducing insulin receptor (InR) expression and some insulin signaling mediators phosphorylation.	Trehalose	147-156	ribosomal protein L10a	Homo sapiens	100-106
33364490-4	2020	In addition, we previously demonstrated that recombinant RpL10a from Fenneropenaeus merguiensis (Fm-RpL10a) could stimulate cell proliferation and trehalose metabolism in RpL10a-over-expressing flies by inducing insulin receptor (InR) expression and some insulin signaling mediators phosphorylation.	Trehalose	147-156	ribosomal protein L10a	Homo sapiens	100-106
33199076-3	2020	The freeze-dried heat-stable formulation ST16, containing excipient combinations of trehalose, glycine, thiourea and phosphate buffer shows the superior thermostability.	Trehalose	84-93	interleukin 24	Homo sapiens	41-45
32876841-6	2020	Trehalose can also increase progranulin expression and rescue abnormalities in lysosomal structure in PHEV-infected cells.	Trehalose	0-9	granulin precursor	Homo sapiens	28-39
32590093-8	2020	Alongwith the fat various biochemical parameters like glucose, trehalose, protein and triglyceride level found to be altered.	Trehalose	63-72	fat	Drosophila melanogaster	14-17
33262593-9	2020	In vitro evaluation and aqueous humor pharmacokinetics further revealed that 2-HP-beta-CD/PLGA NPs had greater trans-ocular permeation and retention compared to chitosan oligosaccharide/PLGA and trehalose/PLGA NPs.	Trehalose	195-204	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	82-89
33138306-6	2020	Similarly, the overexpression of grape sister of ramose 3 (VvSRA), which encodes trehalose 6-phosphate phosphatase that catalyzes the conversion of trehalose-6-phosphate into trehalose, upregulated AtCKX7 expression in Arabidopsis plants, leading to a decrease in the number of flower buds per Arabidopsis inflorescence.	Trehalose	81-90	cytokinin oxidase 7	Arabidopsis thaliana	198-204
33240886-10	2020	In an effort to find the nature of these compounds, we investigated the disaccharide trehalose as putative signaling molecule, since its production is enhanced during L1 arrest and it is able to activate DAF-16.	Trehalose	85-94	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	204-210
33240886-12	2020	The addition of this concentration of trehalose to animals arrested at low density was enough to rescue DAF-28 production and DAF-16 activation to the levels of animals arrested at high density.	Trehalose	38-47	Uncharacterized protein	Caenorhabditis elegans	104-110
33240886-12	2020	The addition of this concentration of trehalose to animals arrested at low density was enough to rescue DAF-28 production and DAF-16 activation to the levels of animals arrested at high density.	Trehalose	38-47	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	126-132
32730893-1	2020	Neuropeptides belonging to the adipokinetic hormone (AKH) family elicit metabolic effects as their main function in insects, by mobilizing trehalose, diacylgycerol, or proline, which are released from the fat body into the hemolymph as energy sources for muscle contraction required for energy-intensive processes, such as locomotion.	Trehalose	139-148	hypertrehalosaemic prohormone	Apis mellifera	53-56
33036195-0	2020	Wine yeast peroxiredoxin TSA1 plays a role in growth, stress response and trehalose metabolism in biomass propagation.	Trehalose	74-83	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	25-29
32666184-6	2020	The improved biofilm formation shown by the rim15  strain could be attributed to an increase in the expression level of the adhesion protein FLO11 and synthesis of trehalose.	Trehalose	164-173	protein kinase RIM15	Saccharomyces cerevisiae S288C	44-49
32167237-1	2020	Trehalose plays important roles in plant growth and stress responses and is synthesized from trehalose-6-phosphate (T6P) by trehalose-6-phosphate phosphatase (TPP).	Trehalose	0-9	trehalose-6-phosphate phosphatase	Arabidopsis thaliana	124-157
32167237-1	2020	Trehalose plays important roles in plant growth and stress responses and is synthesized from trehalose-6-phosphate (T6P) by trehalose-6-phosphate phosphatase (TPP).	Trehalose	0-9	trehalose-6-phosphate phosphatase	Arabidopsis thaliana	159-162
32167237-5	2020	Genetic analysis revealed that TPPE acts downstream of ABF2, which is supported by the findings that TPPE expression and trehalose content are reduced in the abf2 mutant and that a mutation in TPPE abolished the ABA-sensitive root elongation phenotype of 35S:ABF2 plants.	Trehalose	121-130	Haloacid dehalogenase-like hydrolase (HAD) superfamily protein	Arabidopsis thaliana	31-35
32167237-5	2020	Genetic analysis revealed that TPPE acts downstream of ABF2, which is supported by the findings that TPPE expression and trehalose content are reduced in the abf2 mutant and that a mutation in TPPE abolished the ABA-sensitive root elongation phenotype of 35S:ABF2 plants.	Trehalose	121-130	abscisic acid responsive elements-binding factor 2	Arabidopsis thaliana	55-59
32167237-5	2020	Genetic analysis revealed that TPPE acts downstream of ABF2, which is supported by the findings that TPPE expression and trehalose content are reduced in the abf2 mutant and that a mutation in TPPE abolished the ABA-sensitive root elongation phenotype of 35S:ABF2 plants.	Trehalose	121-130	abscisic acid responsive elements-binding factor 2	Arabidopsis thaliana	158-162
33046910-4	2020	Specifically, the ecdysteroid-inducible protein ImpL2 protects against hydrolysis of circulating trehalose following pupal commitment in larvae.	Trehalose	97-106	Ecdysone-inducible gene L2	Drosophila melanogaster	48-53
32930314-5	2020	For the trehalose containing samples with less than 50 wt% myoglobin a fourth relaxation process was observed due to a beta-relaxation of trehalose below Tg.	Trehalose	8-17	myoglobin	Homo sapiens	59-68
32930314-5	2020	For the trehalose containing samples with less than 50 wt% myoglobin a fourth relaxation process was observed due to a beta-relaxation of trehalose below Tg.	Trehalose	8-17	amyloid beta precursor protein	Homo sapiens	117-123
32930314-5	2020	For the trehalose containing samples with less than 50 wt% myoglobin a fourth relaxation process was observed due to a beta-relaxation of trehalose below Tg.	Trehalose	138-147	myoglobin	Homo sapiens	59-68
32930314-5	2020	For the trehalose containing samples with less than 50 wt% myoglobin a fourth relaxation process was observed due to a beta-relaxation of trehalose below Tg.	Trehalose	138-147	amyloid beta precursor protein	Homo sapiens	117-123
32679096-9	2020	Mechanistically, after pupariation, ecdysteroid signaling and the competence factor Ftz-F1 regulates the systematic degradation of circulating trehalose via the transient induction of trehalose transporters and trehalase (Treh) in a timely manner.	Trehalose	143-152	ftz transcription factor 1	Drosophila melanogaster	84-90
32679096-9	2020	Mechanistically, after pupariation, ecdysteroid signaling and the competence factor Ftz-F1 regulates the systematic degradation of circulating trehalose via the transient induction of trehalose transporters and trehalase (Treh) in a timely manner.	Trehalose	143-152	Trehalase	Drosophila melanogaster	211-220
32679096-9	2020	Mechanistically, after pupariation, ecdysteroid signaling and the competence factor Ftz-F1 regulates the systematic degradation of circulating trehalose via the transient induction of trehalose transporters and trehalase (Treh) in a timely manner.	Trehalose	143-152	Trehalase	Drosophila melanogaster	222-226
32621922-3	2020	Trehalose (Tre), a transcription factor EB (TFEB) activator, may impact the autophagy-lysosomal system in AMs during silicosis.	Trehalose	0-9	transcription factor EB	Homo sapiens	19-42
32621922-3	2020	Trehalose (Tre), a transcription factor EB (TFEB) activator, may impact the autophagy-lysosomal system in AMs during silicosis.	Trehalose	0-9	transcription factor EB	Homo sapiens	44-48
32621922-3	2020	Trehalose (Tre), a transcription factor EB (TFEB) activator, may impact the autophagy-lysosomal system in AMs during silicosis.	Trehalose	0-3	transcription factor EB	Homo sapiens	19-42
32621922-3	2020	Trehalose (Tre), a transcription factor EB (TFEB) activator, may impact the autophagy-lysosomal system in AMs during silicosis.	Trehalose	0-3	transcription factor EB	Homo sapiens	44-48
32669036-3	2020	In comparison with wild-type, under dehydration conditions, the expression levels of genes related to photosynthesis and the metabolism of glucosinolates and trehalose were significantly changed in both d14-1 and kai2-2 mutant plants, whereas the transcript levels of genes related to the metabolism of cytokinins and brassinosteroids were significantly altered in the d14-1 mutant plants only.	Trehalose	158-167	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	213-217
32669036-4	2020	These results suggest that cytokinin and brassinosteroid metabolism might be specifically regulated by the D14 pathway, whereas photosynthesis and metabolism of glucosinolates and trehalose are potentially regulated by both D14 and KAI2 pathways in plant response to water scarcity.	Trehalose	180-189	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	232-236
32423188-7	2020	Furthermore, we revealed that about 50% of the AFB1 metabolic activity can be maintained for 3 months when E. coli expressing human CYP3A4 is freeze-dried in the presence of trehalose.	Trehalose	174-183	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	132-138
32868830-0	2020	Trehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells.	Trehalose	0-9	snail family transcriptional repressor 1	Homo sapiens	55-60
32868830-10	2020	Additionally, trehalose attenuated the increase of alpha-SMA and ColIalpha1 mRNA expression induced by TGF-beta1 through Snail protein degradation, which was dependent on autophagy in PMCs.	Trehalose	14-23	actin alpha 1, skeletal muscle	Homo sapiens	51-60
32868830-10	2020	Additionally, trehalose attenuated the increase of alpha-SMA and ColIalpha1 mRNA expression induced by TGF-beta1 through Snail protein degradation, which was dependent on autophagy in PMCs.	Trehalose	14-23	transforming growth factor beta 1	Homo sapiens	103-112
32868830-10	2020	Additionally, trehalose attenuated the increase of alpha-SMA and ColIalpha1 mRNA expression induced by TGF-beta1 through Snail protein degradation, which was dependent on autophagy in PMCs.	Trehalose	14-23	snail family transcriptional repressor 1	Homo sapiens	121-126
32554696-7	2020	Moreover, the inhibition of HIV by trehalose was significantly reduced by knockdown of ATG5 Additionally, trehalose down-regulated the expression of CCR5 in T cells, and CD4 in both T cells and macrophages which reduced HIV entry in these cells.	Trehalose	35-44	CD4 molecule	Homo sapiens	170-173
32554696-7	2020	Moreover, the inhibition of HIV by trehalose was significantly reduced by knockdown of ATG5 Additionally, trehalose down-regulated the expression of CCR5 in T cells, and CD4 in both T cells and macrophages which reduced HIV entry in these cells.	Trehalose	106-115	autophagy related 5	Homo sapiens	87-91
32747529-4	2020	In the presence of sufficient NaCl or osmolytes, trehalose and sorbitol, the NFAT5 NTD undergoes a disorder-to-order shift, adopting higher average secondary and tertiary structure.	Trehalose	49-58	nuclear factor of activated T cells 5	Homo sapiens	77-82
32554696-0	2020	Trehalose Inhibits Human Immunodeficiency Virus type-1 Infection in Primary Human Macrophages and CD4+ T lymphocytes through Two Distinct Mechanisms.	Trehalose	0-9	CD4 molecule	Homo sapiens	98-101
32785678-0	2020	Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress.	Trehalose	0-9	transcription factor EB	Homo sapiens	63-67
32554696-4	2020	Here, we examined the effect on HIV replication of trehalose, a non-toxic, non-reducing disaccharide that induces autophagy through an MTOR independent mechanism.	Trehalose	51-60	mechanistic target of rapamycin kinase	Homo sapiens	135-139
32554696-6	2020	Uninfected and HIV-infected macrophages and T cells treated with trehalose exhibited increased markers of autophagy including LC3B lipidation with further accumulation following bafilomycin A1 treatment, and increased levels of LAMP1, LAMP2 and RAB7 proteins required for lysosomal biogenesis and fusion.	Trehalose	65-74	microtubule associated protein 1 light chain 3 beta	Homo sapiens	126-130
32554696-6	2020	Uninfected and HIV-infected macrophages and T cells treated with trehalose exhibited increased markers of autophagy including LC3B lipidation with further accumulation following bafilomycin A1 treatment, and increased levels of LAMP1, LAMP2 and RAB7 proteins required for lysosomal biogenesis and fusion.	Trehalose	65-74	lysosomal associated membrane protein 1	Homo sapiens	228-233
32554696-6	2020	Uninfected and HIV-infected macrophages and T cells treated with trehalose exhibited increased markers of autophagy including LC3B lipidation with further accumulation following bafilomycin A1 treatment, and increased levels of LAMP1, LAMP2 and RAB7 proteins required for lysosomal biogenesis and fusion.	Trehalose	65-74	lysosomal associated membrane protein 2	Homo sapiens	235-240
32554696-6	2020	Uninfected and HIV-infected macrophages and T cells treated with trehalose exhibited increased markers of autophagy including LC3B lipidation with further accumulation following bafilomycin A1 treatment, and increased levels of LAMP1, LAMP2 and RAB7 proteins required for lysosomal biogenesis and fusion.	Trehalose	65-74	RAB7B, member RAS oncogene family	Homo sapiens	245-249
32554696-7	2020	Moreover, the inhibition of HIV by trehalose was significantly reduced by knockdown of ATG5 Additionally, trehalose down-regulated the expression of CCR5 in T cells, and CD4 in both T cells and macrophages which reduced HIV entry in these cells.	Trehalose	35-44	autophagy related 5	Homo sapiens	87-91
32554696-7	2020	Moreover, the inhibition of HIV by trehalose was significantly reduced by knockdown of ATG5 Additionally, trehalose down-regulated the expression of CCR5 in T cells, and CD4 in both T cells and macrophages which reduced HIV entry in these cells.	Trehalose	35-44	C-C motif chemokine receptor 5	Homo sapiens	149-153
32554696-7	2020	Moreover, the inhibition of HIV by trehalose was significantly reduced by knockdown of ATG5 Additionally, trehalose down-regulated the expression of CCR5 in T cells, and CD4 in both T cells and macrophages which reduced HIV entry in these cells.	Trehalose	106-115	C-C motif chemokine receptor 5	Homo sapiens	149-153
32554696-8	2020	Our data demonstrate that the naturally occurring sugar, trehalose, at doses safely achieved in humans inhibits HIV through two mechanisms: 1) decreased entry through the down-regulation of CCR5 in T-cells, and decreased CD4 expression in both T-cells and macrophages; and 2) degradation of intracellular HIV through the induction of MTOR independent autophagy.	Trehalose	57-66	C-C motif chemokine receptor 5	Homo sapiens	190-194
32554696-8	2020	Our data demonstrate that the naturally occurring sugar, trehalose, at doses safely achieved in humans inhibits HIV through two mechanisms: 1) decreased entry through the down-regulation of CCR5 in T-cells, and decreased CD4 expression in both T-cells and macrophages; and 2) degradation of intracellular HIV through the induction of MTOR independent autophagy.	Trehalose	57-66	CD4 molecule	Homo sapiens	221-224
32554696-8	2020	Our data demonstrate that the naturally occurring sugar, trehalose, at doses safely achieved in humans inhibits HIV through two mechanisms: 1) decreased entry through the down-regulation of CCR5 in T-cells, and decreased CD4 expression in both T-cells and macrophages; and 2) degradation of intracellular HIV through the induction of MTOR independent autophagy.	Trehalose	57-66	mechanistic target of rapamycin kinase	Homo sapiens	334-338
32554696-11	2020	Here, we examined the HIV inhibitory effects of the MTOR independent inducer of autophagy, trehalose.	Trehalose	91-100	mechanistic target of rapamycin kinase	Homo sapiens	52-56
32554696-12	2020	Of note, we identified that in addition to the inhibition of the intracellular replication of HIV by autophagy, trehalose decreased viral entry in human primary macrophages and CD4+ T-cells through the down-regulation of CCR5 in T cells, and CD4 in both T cells and macrophages.	Trehalose	112-121	CD4 molecule	Homo sapiens	177-180
32554696-12	2020	Of note, we identified that in addition to the inhibition of the intracellular replication of HIV by autophagy, trehalose decreased viral entry in human primary macrophages and CD4+ T-cells through the down-regulation of CCR5 in T cells, and CD4 in both T cells and macrophages.	Trehalose	112-121	C-C motif chemokine receptor 5	Homo sapiens	221-225
32554696-12	2020	Of note, we identified that in addition to the inhibition of the intracellular replication of HIV by autophagy, trehalose decreased viral entry in human primary macrophages and CD4+ T-cells through the down-regulation of CCR5 in T cells, and CD4 in both T cells and macrophages.	Trehalose	112-121	CD4 molecule	Homo sapiens	242-245
32649191-3	2020	Here we report hyperbranched polyglycerol dendrimer terminated with anti-amyloidogenic small molecules such as gallate, tyrosine and trehalose and their potential in inhibiting lysozyme/huntingtin protein aggregation under intra/extracellular space.	Trehalose	133-142	lysozyme	Homo sapiens	177-185
32649191-3	2020	Here we report hyperbranched polyglycerol dendrimer terminated with anti-amyloidogenic small molecules such as gallate, tyrosine and trehalose and their potential in inhibiting lysozyme/huntingtin protein aggregation under intra/extracellular space.	Trehalose	133-142	huntingtin	Homo sapiens	186-196
32785678-8	2020	Results: Trehalose reduced the proinflammatory mediators TNF-alpha, IL-1beta, IL-6, and IL-8 in primary HCECs at 450 mOsM.	Trehalose	9-18	tumor necrosis factor	Homo sapiens	57-66
32785678-8	2020	Results: Trehalose reduced the proinflammatory mediators TNF-alpha, IL-1beta, IL-6, and IL-8 in primary HCECs at 450 mOsM.	Trehalose	9-18	interleukin 1 alpha	Homo sapiens	68-76
32785678-8	2020	Results: Trehalose reduced the proinflammatory mediators TNF-alpha, IL-1beta, IL-6, and IL-8 in primary HCECs at 450 mOsM.	Trehalose	9-18	interleukin 6	Homo sapiens	78-82
32785678-8	2020	Results: Trehalose reduced the proinflammatory mediators TNF-alpha, IL-1beta, IL-6, and IL-8 in primary HCECs at 450 mOsM.	Trehalose	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
32785678-10	2020	Trehalose promoted autophagosome formation and autophagic flux, as evidenced by increased production of Beclin1, Atg5, and Atg7, as well as higher LC3B I protein turnover to LC3B II, with decreased protein levels of P62/SQSTM1.	Trehalose	0-9	beclin 1	Homo sapiens	104-111
32785678-10	2020	Trehalose promoted autophagosome formation and autophagic flux, as evidenced by increased production of Beclin1, Atg5, and Atg7, as well as higher LC3B I protein turnover to LC3B II, with decreased protein levels of P62/SQSTM1.	Trehalose	0-9	autophagy related 5	Homo sapiens	113-117
32785678-10	2020	Trehalose promoted autophagosome formation and autophagic flux, as evidenced by increased production of Beclin1, Atg5, and Atg7, as well as higher LC3B I protein turnover to LC3B II, with decreased protein levels of P62/SQSTM1.	Trehalose	0-9	autophagy related 7	Homo sapiens	123-127
32785678-10	2020	Trehalose promoted autophagosome formation and autophagic flux, as evidenced by increased production of Beclin1, Atg5, and Atg7, as well as higher LC3B I protein turnover to LC3B II, with decreased protein levels of P62/SQSTM1.	Trehalose	0-9	microtubule associated protein 1 light chain 3 beta	Homo sapiens	147-151
32785678-10	2020	Trehalose promoted autophagosome formation and autophagic flux, as evidenced by increased production of Beclin1, Atg5, and Atg7, as well as higher LC3B I protein turnover to LC3B II, with decreased protein levels of P62/SQSTM1.	Trehalose	0-9	microtubule associated protein 1 light chain 3 beta	Homo sapiens	174-178
32785678-10	2020	Trehalose promoted autophagosome formation and autophagic flux, as evidenced by increased production of Beclin1, Atg5, and Atg7, as well as higher LC3B I protein turnover to LC3B II, with decreased protein levels of P62/SQSTM1.	Trehalose	0-9	sequestosome 1	Homo sapiens	216-219
32785678-10	2020	Trehalose promoted autophagosome formation and autophagic flux, as evidenced by increased production of Beclin1, Atg5, and Atg7, as well as higher LC3B I protein turnover to LC3B II, with decreased protein levels of P62/SQSTM1.	Trehalose	0-9	sequestosome 1	Homo sapiens	220-226
32785678-12	2020	Trehalose further activated TFEB, with translocation from cytoplasm to the nucleus, but diminished Akt activity.	Trehalose	0-9	transcription factor EB	Homo sapiens	28-32
32785678-12	2020	Trehalose further activated TFEB, with translocation from cytoplasm to the nucleus, but diminished Akt activity.	Trehalose	0-9	AKT serine/threonine kinase 1	Homo sapiens	99-102
32785678-13	2020	Conclusions: Our findings demonstrate that trehalose, functioning as an autophagy enhancer, suppresses the inflammatory response by promoting autophagic flux via TFEB activation in primary HCECs exposed to hyperosmotic stress, a process that is beneficial to dry eye.	Trehalose	43-52	transcription factor EB	Homo sapiens	162-166
32447719-5	2020	We further verified that trehalose, a safe clinical drug, could alleviate TGF-beta1-induced fibrosis of hSCFs by activating autophagy and that these effects could be blocked by autophagy inhibition.	Trehalose	25-34	transforming growth factor beta 1	Homo sapiens	74-83
32333458-8	2020	It is intriguing that trehalose, a natural disaccharide, could rescue ambra1a-MO knockdown in a dose-dependent manner independently or together with AMBRA1 mRNA.	Trehalose	22-31	autophagy/beclin-1 regulator 1a	Danio rerio	149-155
32774677-6	2020	In addition, the mRNA levels of key molecular targets implicated in RPE damage and AMD, such as vascular endothelial growth factor- (VEGF-) A and heat shock protein 27 (HSP27), were downregulated, whereas NRF2 was upregulated by trehalose.	Trehalose	229-238	heat shock protein family B (small) member 2	Homo sapiens	169-174
32774677-9	2020	The cytoprotection by trehalose was dependent on autophagy but not NRF2 activation, since autophagy inhibition by shRNA knockdown of ATG5 led to a loss of the protective effect.	Trehalose	22-31	autophagy related 5	Homo sapiens	133-137
32774677-10	2020	The results support the transcriptional upregulation of TFEB and autophagy by trehalose and its protection against HQ-induced oxidative damage in RPE cells.	Trehalose	78-87	transcription factor EB	Homo sapiens	56-60
32774677-11	2020	Further investigation is, therefore, warranted into the therapeutic value of trehalose in alleviating AMD and retinal diseases associated with impaired NRF2 antioxidant defense.	Trehalose	77-86	NFE2 like bZIP transcription factor 2	Homo sapiens	152-156
32488697-0	2020	Trehalose Inhibits Abeta Generation and Plaque Formation in Alzheimer"s Disease.	Trehalose	0-9	amyloid beta (A4) precursor protein	Mus musculus	19-24
32488697-6	2020	Trehalose treatment significantly decreased Abeta generation in HAW and 20E2 cells.	Trehalose	0-9	amyloid beta (A4) precursor protein	Mus musculus	44-49
32488697-7	2020	Furthermore, trehalose treatment increased the levels of APP and its CTFs, and significantly reduced Abeta generation and neuritic plaque formation in APP23 mice.	Trehalose	13-22	amyloid beta (A4) precursor protein	Mus musculus	101-106
32488697-8	2020	Our study showed that trehalose affected the APP processing both in vitro and in vivo and suggests that trehalose treatment may offer as a therapeutic strategy to ameliorate AD pathology by inhibiting Abeta generation and neuritic plaque formation.	Trehalose	22-31	amyloid beta (A4) precursor protein	Mus musculus	201-206
32774677-0	2020	Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells.	Trehalose	43-52	transcription factor EB	Homo sapiens	30-34
32774677-0	2020	Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells.	Trehalose	43-52	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
32774677-2	2020	The role of trehalose in the management of age-related macular degeneration (AMD) is yet to be investigated and whether trehalose could be a remedy for the treatment of diseases linked to oxidative stress and NRF2 dysregulation.	Trehalose	120-129	NFE2 like bZIP transcription factor 2	Homo sapiens	209-213
32774677-3	2020	Here, we showed that incubation of human retinal pigment epithelial (RPE) cells with trehalose enhanced the mRNA and protein expressions of TFEB, autophagy genes ATG5 and ATG7, as well as protein expressions of macroautophagy markers, LC3B and p62/SQTM1, and the chaperone-mediated autophagy (CMA) receptor LAMP2.	Trehalose	85-94	transcription factor EB	Homo sapiens	140-144
32774677-3	2020	Here, we showed that incubation of human retinal pigment epithelial (RPE) cells with trehalose enhanced the mRNA and protein expressions of TFEB, autophagy genes ATG5 and ATG7, as well as protein expressions of macroautophagy markers, LC3B and p62/SQTM1, and the chaperone-mediated autophagy (CMA) receptor LAMP2.	Trehalose	85-94	autophagy related 5	Homo sapiens	162-166
32774677-3	2020	Here, we showed that incubation of human retinal pigment epithelial (RPE) cells with trehalose enhanced the mRNA and protein expressions of TFEB, autophagy genes ATG5 and ATG7, as well as protein expressions of macroautophagy markers, LC3B and p62/SQTM1, and the chaperone-mediated autophagy (CMA) receptor LAMP2.	Trehalose	85-94	autophagy related 7	Homo sapiens	171-175
32774677-3	2020	Here, we showed that incubation of human retinal pigment epithelial (RPE) cells with trehalose enhanced the mRNA and protein expressions of TFEB, autophagy genes ATG5 and ATG7, as well as protein expressions of macroautophagy markers, LC3B and p62/SQTM1, and the chaperone-mediated autophagy (CMA) receptor LAMP2.	Trehalose	85-94	microtubule associated protein 1 light chain 3 beta	Homo sapiens	235-239
32774677-3	2020	Here, we showed that incubation of human retinal pigment epithelial (RPE) cells with trehalose enhanced the mRNA and protein expressions of TFEB, autophagy genes ATG5 and ATG7, as well as protein expressions of macroautophagy markers, LC3B and p62/SQTM1, and the chaperone-mediated autophagy (CMA) receptor LAMP2.	Trehalose	85-94	nucleoporin 62	Homo sapiens	244-247
32774677-3	2020	Here, we showed that incubation of human retinal pigment epithelial (RPE) cells with trehalose enhanced the mRNA and protein expressions of TFEB, autophagy genes ATG5 and ATG7, as well as protein expressions of macroautophagy markers, LC3B and p62/SQTM1, and the chaperone-mediated autophagy (CMA) receptor LAMP2.	Trehalose	85-94	lysosomal associated membrane protein 2	Homo sapiens	307-312
32774677-4	2020	Cathepsin D, a hydrolytic lysosomal enzyme, was also increased by trehalose, indicating higher proteolytic activity.	Trehalose	66-75	cathepsin D	Homo sapiens	0-11
32774677-5	2020	Moreover, trehalose upregulated autophagy flux evident by an increase in the endogenous LC3B level, and accumulation of GFP-LC3B puncta and free GFP fragments in GFP-LC3 - expressing cells in the presence of chloroquine.	Trehalose	10-19	microtubule associated protein 1 light chain 3 beta	Homo sapiens	88-92
32774677-5	2020	Moreover, trehalose upregulated autophagy flux evident by an increase in the endogenous LC3B level, and accumulation of GFP-LC3B puncta and free GFP fragments in GFP-LC3 - expressing cells in the presence of chloroquine.	Trehalose	10-19	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	88-91
32447719-0	2020	Trehalose attenuates TGF-beta1-induced fibrosis of hSCFs by activating autophagy.	Trehalose	0-9	transforming growth factor beta 1	Homo sapiens	21-30
32488697-8	2020	Our study showed that trehalose affected the APP processing both in vitro and in vivo and suggests that trehalose treatment may offer as a therapeutic strategy to ameliorate AD pathology by inhibiting Abeta generation and neuritic plaque formation.	Trehalose	104-113	amyloid beta (A4) precursor protein	Mus musculus	201-206
32447719-7	2020	More importantly, the protective effects of trehalose on TGF-beta1-induced fibrosis of hSCFs were mediated by the activation of autophagy and could provide possible new approaches for the clinical treatment of conjunctival fibrosis.	Trehalose	44-53	transforming growth factor beta 1	Homo sapiens	57-66
32369347-0	2020	Synthesis of Zwitterionic and Trehalose Polymers with Variable Degradation Rates and Stabilization of Insulin.	Trehalose	30-39	insulin	Homo sapiens	102-109
32369347-3	2020	Specifically, zwitterion- and trehalose-substituted polycaprolactone, polyvalerolactone, polycarbonate, and polylactide were prepared and characterized with regards to their hydrolytic degradation and ability to stabilize insulin to mechanical agitation during heat.	Trehalose	30-39	insulin	Homo sapiens	222-229
32367591-10	2020	Thus, trehalose could decrease osteoblast-mediated osteoclastogenesis and reduce PBC-related bone loss by regulating ERK phosphorylation via autophagosome formation.	Trehalose	6-15	mitogen-activated protein kinase 1	Mus musculus	117-120
32272938-7	2020	Trehalose-mediated improvements in motor behaviour were associated with a reduction of the MJD-associated neuropathology, as MJD transgenic mice treated with trehalose presented preservation of cerebellar layers thickness and a decrease in the size of ataxin-3 aggregates in Purkinje cells.	Trehalose	0-9	ataxin 3	Mus musculus	252-260
32367591-0	2020	Trehalose reduces bone loss in experimental biliary cirrhosis rats via ERK phosphorylation regulation by enhancing autophagosome formation.	Trehalose	0-9	Eph receptor B1	Rattus norvegicus	71-74
32367591-5	2020	The results demonstrated that trehalose reduced osteoporosis of BDL rats and decreased osteoblast-mediated osteoclast differentiation by enhancing osteoblast autophagy to regulate osteoprotegerin (OPG) secretion.	Trehalose	30-39	TNF receptor superfamily member 11B	Rattus norvegicus	180-195
32367591-5	2020	The results demonstrated that trehalose reduced osteoporosis of BDL rats and decreased osteoblast-mediated osteoclast differentiation by enhancing osteoblast autophagy to regulate osteoprotegerin (OPG) secretion.	Trehalose	30-39	TNF receptor superfamily member 11B	Rattus norvegicus	197-200
32367591-7	2020	Furthermore, trehalose increased the phosphorylation of ERK1/2 in MC3T3-E1 cells, and the ERK inhibitor PD98059 reversed the upregulation of OPG gene and reduction of trehalose-induced osteoclastogeneis.	Trehalose	13-22	mitogen-activated protein kinase 3	Mus musculus	56-62
32367591-7	2020	Furthermore, trehalose increased the phosphorylation of ERK1/2 in MC3T3-E1 cells, and the ERK inhibitor PD98059 reversed the upregulation of OPG gene and reduction of trehalose-induced osteoclastogeneis.	Trehalose	13-22	mitogen-activated protein kinase 1	Mus musculus	56-59
32188623-2	2020	Our previous study demonstrated a toll-like receptor (TLR) and C-type lectin receptor (CLR) agonist pairing of monophosphoryl lipid A (MPL) and trehalose-6,6"-dicorynomycolate (TDCM) effectively inhibits tumor growth and ascites development following TA3-Ha and EL4 challenge through a mechanism dependent upon B-1a cell-produced natural IgM and complement.	Trehalose	144-153	calcitonin receptor	Mus musculus	63-85
32188623-2	2020	Our previous study demonstrated a toll-like receptor (TLR) and C-type lectin receptor (CLR) agonist pairing of monophosphoryl lipid A (MPL) and trehalose-6,6"-dicorynomycolate (TDCM) effectively inhibits tumor growth and ascites development following TA3-Ha and EL4 challenge through a mechanism dependent upon B-1a cell-produced natural IgM and complement.	Trehalose	144-153	calcitonin receptor	Mus musculus	87-90
32188623-2	2020	Our previous study demonstrated a toll-like receptor (TLR) and C-type lectin receptor (CLR) agonist pairing of monophosphoryl lipid A (MPL) and trehalose-6,6"-dicorynomycolate (TDCM) effectively inhibits tumor growth and ascites development following TA3-Ha and EL4 challenge through a mechanism dependent upon B-1a cell-produced natural IgM and complement.	Trehalose	144-153	RIKEN cDNA 2700049A03 gene	Mus musculus	251-254
32188623-2	2020	Our previous study demonstrated a toll-like receptor (TLR) and C-type lectin receptor (CLR) agonist pairing of monophosphoryl lipid A (MPL) and trehalose-6,6"-dicorynomycolate (TDCM) effectively inhibits tumor growth and ascites development following TA3-Ha and EL4 challenge through a mechanism dependent upon B-1a cell-produced natural IgM and complement.	Trehalose	144-153	epilepsy 4	Mus musculus	262-265
32414105-4	2020	In this work we studied the influence exerted by the osmolyte trehalose on fibrillation of two model proteins, that is, lysozyme and insulin, investigated during concomitant variation of the solution ionic strength due to NaCl.	Trehalose	62-71	lysozyme	Homo sapiens	120-128
32414105-4	2020	In this work we studied the influence exerted by the osmolyte trehalose on fibrillation of two model proteins, that is, lysozyme and insulin, investigated during concomitant variation of the solution ionic strength due to NaCl.	Trehalose	62-71	insulin	Homo sapiens	133-140
32319521-1	2020	Trehalose is a non-reducing disaccharide composed of two alpha-glucose molecules and synthesized by an enzyme complex containing four subunits TPS1 (EC 2.4.1.15), TPS2 (EC 3.1.3.12), TPS3, and TSL1.	Trehalose	0-9	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	143-147
32319521-1	2020	Trehalose is a non-reducing disaccharide composed of two alpha-glucose molecules and synthesized by an enzyme complex containing four subunits TPS1 (EC 2.4.1.15), TPS2 (EC 3.1.3.12), TPS3, and TSL1.	Trehalose	0-9	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	163-167
32319521-1	2020	Trehalose is a non-reducing disaccharide composed of two alpha-glucose molecules and synthesized by an enzyme complex containing four subunits TPS1 (EC 2.4.1.15), TPS2 (EC 3.1.3.12), TPS3, and TSL1.	Trehalose	0-9	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	183-187
32319521-1	2020	Trehalose is a non-reducing disaccharide composed of two alpha-glucose molecules and synthesized by an enzyme complex containing four subunits TPS1 (EC 2.4.1.15), TPS2 (EC 3.1.3.12), TPS3, and TSL1.	Trehalose	0-9	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	193-197
32483422-0	2020	Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury.	Trehalose	41-50	transcription factor EB	Mus musculus	14-18
32483422-5	2020	Based on the transcriptional regulation role of transcription factor EB (TFEB) in autophagy and lysosome, we characterized trehalose-induced nuclear translocation of TFEB.	Trehalose	123-132	transcription factor EB	Mus musculus	48-71
32483422-5	2020	Based on the transcriptional regulation role of transcription factor EB (TFEB) in autophagy and lysosome, we characterized trehalose-induced nuclear translocation of TFEB.	Trehalose	123-132	transcription factor EB	Mus musculus	73-77
32483422-5	2020	Based on the transcriptional regulation role of transcription factor EB (TFEB) in autophagy and lysosome, we characterized trehalose-induced nuclear translocation of TFEB.	Trehalose	123-132	transcription factor EB	Mus musculus	166-170
32483422-6	2020	Furthermore, consistent with trehalose treatment, overexpression of TFEB inhibited cell injury induced by cisplatin.	Trehalose	29-38	transcription factor EB	Mus musculus	68-72
32483422-7	2020	However, the protective effects of trehalose were largely abrogated in tfeb-knockdown cells.	Trehalose	35-44	transcription factor EB	Mus musculus	71-75
32483422-9	2020	Trehalose administration activated TFEB-mediated autophagy, alleviated mitochondrial dysfunction and kidney injury in AKI mice.	Trehalose	0-9	transcription factor EB	Mus musculus	35-39
32483422-10	2020	Innovation and conclusion: Our data suggest that trehalose treatment preserves mitochondria function via activation of TFEB-mediated autophagy and attenuates cisplatin-induced kidney injury.	Trehalose	49-58	transcription factor EB	Mus musculus	119-123
32321922-5	2020	Trehalose derived from nematodes affects the intestinal microbiota and increases the abundance of Ruminococcus spp., resulting in the induction of CD8+ Treg cells.	Trehalose	0-9	CD8a molecule	Homo sapiens	147-150
32275682-8	2020	AKT inhibitors MK-2206 and trehalose significantly inhibited AKT phosphorylation and stimulated nuclear translocation of TFEB.	Trehalose	27-36	thymoma viral proto-oncogene 1	Mus musculus	0-3
32275682-8	2020	AKT inhibitors MK-2206 and trehalose significantly inhibited AKT phosphorylation and stimulated nuclear translocation of TFEB.	Trehalose	27-36	thymoma viral proto-oncogene 1	Mus musculus	61-64
32275682-8	2020	AKT inhibitors MK-2206 and trehalose significantly inhibited AKT phosphorylation and stimulated nuclear translocation of TFEB.	Trehalose	27-36	transcription factor EB	Mus musculus	121-125
32319521-0	2020	Deletion of the trehalose tps1 gene in Kluyveromyces lactis does not impair growth in glucose.	Trehalose	16-25	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	26-30
32272938-7	2020	Trehalose-mediated improvements in motor behaviour were associated with a reduction of the MJD-associated neuropathology, as MJD transgenic mice treated with trehalose presented preservation of cerebellar layers thickness and a decrease in the size of ataxin-3 aggregates in Purkinje cells.	Trehalose	158-167	ataxin 3	Mus musculus	252-260
31925485-6	2020	In this review, I focus on diverse and common features of trehalases within different GH families and their contributions to microbial trehalose metabolism.	Trehalose	135-144	gamma-glutamyl hydrolase	Homo sapiens	86-88
31838076-4	2020	We investigated whether a trehalase-resistant analogue of trehalose (lactotrehalose) has the same metabolic effects of trehalose without expanding C difficile.	Trehalose	58-67	trehalase (brush-border membrane glycoprotein)	Mus musculus	26-35
31838076-4	2020	We investigated whether a trehalase-resistant analogue of trehalose (lactotrehalose) has the same metabolic effects of trehalose without expanding C difficile.	Trehalose	74-83	trehalase (brush-border membrane glycoprotein)	Mus musculus	26-35
31838076-21	2020	CONCLUSIONS: Lactotrehalose is a trehalase-resistant analogue that increases metabolic parameters, compared with trehalose, without increasing the abundance or virulence of C difficile strain CD027.	Trehalose	18-27	trehalase (brush-border membrane glycoprotein)	Mus musculus	33-42
31838076-22	2020	Trehalase-resistant trehalose analogues might be developed as next-generation fasting-mimetics for treatment of diabetes and nonalcoholic fatty liver disease.	Trehalose	20-29	trehalase (brush-border membrane glycoprotein)	Mus musculus	0-9
32206077-0	2020	Trehalose itself plays a critical role on lipid metabolism: Trehalose increases jejunum cytoplasmic lipid droplets which negatively correlated with mesenteric adipocyte size in both HFD-fed trehalase KO and WT mice.	Trehalose	0-9	trehalase (brush-border membrane glycoprotein)	Mus musculus	190-199
32206077-0	2020	Trehalose itself plays a critical role on lipid metabolism: Trehalose increases jejunum cytoplasmic lipid droplets which negatively correlated with mesenteric adipocyte size in both HFD-fed trehalase KO and WT mice.	Trehalose	60-69	trehalase (brush-border membrane glycoprotein)	Mus musculus	190-199
32206077-2	2020	Trehalase hydrolyzes trehalose in the small intestine into two glucose molecules.	Trehalose	21-30	trehalase	Homo sapiens	0-9
32206077-6	2020	Results: Trehalose treatment was associated with suppressed adipocyte hypertrophy in both trehalase KO and WT mice.	Trehalose	9-18	trehalase (brush-border membrane glycoprotein)	Mus musculus	90-99
32206077-7	2020	The rate of CLDs in the jejunal epithelium was increased in both trehalase KO and WT mice given water containing trehalose relative to untreated control mice.	Trehalose	113-122	trehalase (brush-border membrane glycoprotein)	Mus musculus	65-74
32206077-9	2020	Chylomicron-TG tended to be decreased in both trehalose-treated trehalase KO and WT mice.	Trehalose	46-55	trehalase (brush-border membrane glycoprotein)	Mus musculus	64-73
32206077-10	2020	Addition of trehalose to differentiated Caco-2 cells in vitro increased intracytoplasmic lipid droplets and decreased secretion of the chylomicron marker ApoB-48.	Trehalose	12-21	apolipoprotein B	Homo sapiens	154-161
32206077-13	2020	Conclusions: The suppression of adipocyte hypertrophy in the presence and absence of trehalase indicates that trehalose mediates effects prior to being hydrolyzed into glucose.	Trehalose	110-119	trehalase	Homo sapiens	85-94
32206077-14	2020	In both trehalase KO and WT mice, trehalose treatment increased the rate of CLDs in jejunal epithelium, reduced chylomicron migration from the intestinal epithelium to the periphery, and suppressed adipocyte hypertrophy.	Trehalose	34-43	trehalase (brush-border membrane glycoprotein)	Mus musculus	8-17
32265497-6	2020	Furthermore, mutations in trehalose synthesis enzyme (Tps1) increased the among-individual and within-individual variations in wing size.	Trehalose	26-35	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	54-58
32068461-8	2020	The in vivo results showed that the renal damage induced by IR was ameliorated by Tre treatment, as the renal histology and renal function were improved and the enhanced protein levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were blocked.	Trehalose	82-85	hepatitis A virus cellular receptor 1	Mus musculus	188-212
32068461-8	2020	The in vivo results showed that the renal damage induced by IR was ameliorated by Tre treatment, as the renal histology and renal function were improved and the enhanced protein levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were blocked.	Trehalose	82-85	hepatitis A virus cellular receptor 1	Mus musculus	214-219
32068461-8	2020	The in vivo results showed that the renal damage induced by IR was ameliorated by Tre treatment, as the renal histology and renal function were improved and the enhanced protein levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were blocked.	Trehalose	82-85	lipocalin 2	Mus musculus	225-267
32068461-8	2020	The in vivo results showed that the renal damage induced by IR was ameliorated by Tre treatment, as the renal histology and renal function were improved and the enhanced protein levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were blocked.	Trehalose	82-85	lipocalin 2	Mus musculus	269-273
32035996-0	2020	SILAC-based proteomic profiling of the suppression of TGF-beta1-induced lung fibroblast-to-myofibroblast differentiation by trehalose.	Trehalose	124-133	transforming growth factor beta 1	Homo sapiens	54-63
32035996-4	2020	In this work, we found that trehalose decreased the expression levels of alpha-smooth muscle actin (alpha-SMA) following the induction of transforming growth factor beta1 (TGF-beta1) in pretreatment, co-treatment, and post-treatment groups.	Trehalose	28-37	actin alpha 1, skeletal muscle	Homo sapiens	100-109
32035996-4	2020	In this work, we found that trehalose decreased the expression levels of alpha-smooth muscle actin (alpha-SMA) following the induction of transforming growth factor beta1 (TGF-beta1) in pretreatment, co-treatment, and post-treatment groups.	Trehalose	28-37	transforming growth factor beta 1	Homo sapiens	138-170
32035996-4	2020	In this work, we found that trehalose decreased the expression levels of alpha-smooth muscle actin (alpha-SMA) following the induction of transforming growth factor beta1 (TGF-beta1) in pretreatment, co-treatment, and post-treatment groups.	Trehalose	28-37	transforming growth factor beta 1	Homo sapiens	172-181
32035996-5	2020	Trehalose also reduced the production of type I collagen, lung fibroblast-containing gel contractility and cell filament formation in TGF-beta1-stimulated MRC-5 cells.	Trehalose	0-9	transforming growth factor beta 1	Homo sapiens	134-143
32035996-8	2020	By applying proteomic profiling technology, we demonstrated that the downregulation of beta-catenin was involved in the trehalose-repressive action on fibroblast differentiation.	Trehalose	120-129	catenin beta 1	Homo sapiens	87-99
32035996-9	2020	The beta-catenin agonist, SKL2001, reversed the suppressive effect of trehalose on fibroblast differentiation.	Trehalose	70-79	catenin beta 1	Homo sapiens	4-16
32035996-10	2020	Overall, these experiments demonstrated that trehalose suppressed fibroblast differentiation via the downregulation of beta-catenin, but not through canonical autophagy and TGFbeta/Smad2/3 pathway, which is not only a novel understanding of trehalose, but also quite helpful for in vivo research of trehalose on pulmonary fibrosis in future.	Trehalose	45-54	catenin beta 1	Homo sapiens	119-131
31800305-9	2020	The presence of trehalose upregulates the expression of both the antiapoptotic gene BCL-2 and proapoptotic genes BAX and BAD.	Trehalose	16-25	BCL2 apoptosis regulator	Homo sapiens	84-89
31800305-9	2020	The presence of trehalose upregulates the expression of both the antiapoptotic gene BCL-2 and proapoptotic genes BAX and BAD.	Trehalose	16-25	BCL2 associated X, apoptosis regulator	Homo sapiens	113-116
31800305-0	2020	Effects of Me2SO and Trehalose on the Cell Viability, Proliferation, and Bcl-2 Family Gene (BCL-2, BAX, and BAD) Expression in Cryopreserved Human Breast Cancer Cells.	Trehalose	21-30	BCL2 apoptosis regulator	Homo sapiens	73-78
31800305-5	2020	The use of Me2SO and trehalose has affected cell survival, proliferation, apoptotic state, as well as BCL-2 family gene expression.	Trehalose	21-30	BCL2 apoptosis regulator	Homo sapiens	102-107
31630800-0	2020	Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability.	Trehalose	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
31947943-0	2020	Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.	Trehalose	0-9	transcription factor EB	Homo sapiens	89-93
31947943-7	2020	However, TFEB overexpression or treatment with the TFEB activator trehalose (Tre) alleviated lysosomal dysfunction and enhanced autophagic flux.	Trehalose	66-75	transcription factor EB	Homo sapiens	51-55
31947943-7	2020	However, TFEB overexpression or treatment with the TFEB activator trehalose (Tre) alleviated lysosomal dysfunction and enhanced autophagic flux.	Trehalose	77-80	transcription factor EB	Homo sapiens	9-13
31947943-7	2020	However, TFEB overexpression or treatment with the TFEB activator trehalose (Tre) alleviated lysosomal dysfunction and enhanced autophagic flux.	Trehalose	77-80	transcription factor EB	Homo sapiens	51-55
31947943-9	2020	Both pharmacologically inhibition of autophagy and TFEB knockdown in macrophages significantly abolished the antiapoptotic and anti-inflammatory effects elicited by either TFEB overexpression or Tre treatment.	Trehalose	195-198	transcription factor EB	Homo sapiens	51-55
31947943-11	2020	Our study suggests that restoration of autophagy-lysosomal function by Tre-induced TFEB activation may be a novel strategy for the treatment of silicosis.	Trehalose	71-74	transcription factor EB	Homo sapiens	83-87
31630800-7	2020	In conclusion, trehalose play an anti-aging role by activating genes related to Nrf2 pathway.	Trehalose	15-24	nuclear factor, erythroid derived 2, like 2	Mus musculus	80-84
31478225-3	2020	The trehalose-6-phosphate synthase (TPS1) is an enzyme responsible for the biosynthesis of trehalose-6-phosphate (T6P) in the TPS1/TPS2 pathway, which results in the formation of trehalose.	Trehalose	4-13	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	36-40
31478225-3	2020	The trehalose-6-phosphate synthase (TPS1) is an enzyme responsible for the biosynthesis of trehalose-6-phosphate (T6P) in the TPS1/TPS2 pathway, which results in the formation of trehalose.	Trehalose	4-13	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	126-130
31478225-3	2020	The trehalose-6-phosphate synthase (TPS1) is an enzyme responsible for the biosynthesis of trehalose-6-phosphate (T6P) in the TPS1/TPS2 pathway, which results in the formation of trehalose.	Trehalose	4-13	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	131-135
31478225-4	2020	Studies carried out by our group demonstrated the inhibitory capacity of T6P in the TPS1 enzyme from Saccharomyces cerevisiae, preventing the synthesis of trehalose.	Trehalose	155-164	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	84-88
31906434-5	2020	The longevity of daf-2 mutants seems to be partially supported by endogenous trehalose, a nonreducing disaccharide that mammals cannot synthesize, which points toward considerable differences in downstream mechanisms by which IIS regulates aging in distinct groups.	Trehalose	77-86	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	17-22
31630800-5	2020	Further studies have shown that trehalose activates the expressions of downstream target genes HO-1, NQO1, SOD, GSH and CAT by promoting the nuclear translocation of Nrf2 in the liver.	Trehalose	32-41	heme oxygenase 1	Mus musculus	95-99
31630800-5	2020	Further studies have shown that trehalose activates the expressions of downstream target genes HO-1, NQO1, SOD, GSH and CAT by promoting the nuclear translocation of Nrf2 in the liver.	Trehalose	32-41	NAD(P)H dehydrogenase, quinone 1	Mus musculus	101-105
31630800-5	2020	Further studies have shown that trehalose activates the expressions of downstream target genes HO-1, NQO1, SOD, GSH and CAT by promoting the nuclear translocation of Nrf2 in the liver.	Trehalose	32-41	catalase	Mus musculus	120-123
31630800-5	2020	Further studies have shown that trehalose activates the expressions of downstream target genes HO-1, NQO1, SOD, GSH and CAT by promoting the nuclear translocation of Nrf2 in the liver.	Trehalose	32-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	166-170
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Trehalose	4-13	trehalose-6-phosphate synthase	Medicago truncatula	95-125
32418522-6	2020	Betaine, sucrose and trehalose supplementation has been seen to induce autophagy thereby inhibiting the accumulation of Abeta.	Trehalose	21-30	amyloid beta precursor protein	Homo sapiens	120-125
31678247-3	2020	In-situ Raman investigations, performed during the FD process have revealed that sucrose was more efficient than trehalose for preserving the secondary structure of lysozyme during FD, especially during the primary drying stage.	Trehalose	113-122	lysozyme	Homo sapiens	165-173
31521883-9	2020	Trehalose treatment led to the increased expression of LC3, an autophagy marker, in metaphase II oocytes and 4-cell stage embryos.	Trehalose	0-9	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	55-58
31521883-10	2020	Gene expression analysis revealed that the expression of several autophagy related genes (LAMP2, pATG5, and LC3) increased, while the Bax/Bcl2 ratio and pro-apoptotic Bak transcript levels were decreased in the trehalose-treated group.	Trehalose	211-220	lysosomal associated membrane protein 2	Homo sapiens	90-95
31521883-10	2020	Gene expression analysis revealed that the expression of several autophagy related genes (LAMP2, pATG5, and LC3) increased, while the Bax/Bcl2 ratio and pro-apoptotic Bak transcript levels were decreased in the trehalose-treated group.	Trehalose	211-220	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	108-111
31521883-10	2020	Gene expression analysis revealed that the expression of several autophagy related genes (LAMP2, pATG5, and LC3) increased, while the Bax/Bcl2 ratio and pro-apoptotic Bak transcript levels were decreased in the trehalose-treated group.	Trehalose	211-220	BCL2 associated X, apoptosis regulator	Homo sapiens	134-137
31521883-10	2020	Gene expression analysis revealed that the expression of several autophagy related genes (LAMP2, pATG5, and LC3) increased, while the Bax/Bcl2 ratio and pro-apoptotic Bak transcript levels were decreased in the trehalose-treated group.	Trehalose	211-220	BCL2 apoptosis regulator	Homo sapiens	138-142
31497924-0	2020	Protective effects of trehalose against Mn-induced alpha-synuclein oligomerization in mice: Involvement of oxidative stress and autophagy.	Trehalose	22-31	synuclein, alpha	Mus musculus	51-66
31497924-3	2020	In this study, we investigate whether trehalose can effectively interfere with Mn-induced alpha-Syn oligomerization, using different concentrations of trehalose (2% and 4% (g/vol [mL])) in a mouse model of manganism.	Trehalose	38-47	synuclein, alpha	Mus musculus	90-99
31497924-5	2020	Our results also revealed that pretreatment with trehalose significantly reduced the oxidative damage to alpha-Syn protein and increased autophagy activation.	Trehalose	49-58	synuclein, alpha	Mus musculus	105-114
31497924-6	2020	These findings clearly demonstrated that trehalose can relieve Mn-induced alpha-Syn oligomerization and neuronal cell damage through its anti-oxidative and autophagy-inducing effects.	Trehalose	41-50	joined toes	Mus musculus	80-83
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Trehalose	95-104	probable trehalase	Medicago truncatula	322-331
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Trehalose	95-104	probable trehalase	Medicago truncatula	333-336
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Trehalose	4-13	trehalose-6-phosphate synthase	Medicago truncatula	127-130
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Trehalose	4-13	probable trehalase	Medicago truncatula	322-331
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Trehalose	4-13	probable trehalase	Medicago truncatula	333-336
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Trehalose	95-106	trehalose-6-phosphate synthase	Medicago truncatula	127-130
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Trehalose	95-106	probable trehalase	Medicago truncatula	322-331
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Trehalose	95-106	probable trehalase	Medicago truncatula	333-336
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Trehalose	95-104	trehalose-6-phosphate synthase	Medicago truncatula	127-130
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Trehalose	95-104	probable trehalase	Medicago truncatula	322-331
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Trehalose	95-104	probable trehalase	Medicago truncatula	333-336
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Trehalose	95-104	trehalose-6-phosphate synthase	Medicago truncatula	127-130
31817132-3	2019	Exogenous Tre in the stress treatments increased all of the growth parameters as well as decreased the salinity, low P, and combined stress-mediated Na+/K+, reactive oxygen species (ROS), malondialdehyde (MDA), lipoxygenase (LOX) activity, and methylglyoxal (MG) in both genotypes.	Trehalose	10-13	linoleate 9S-lipoxygenase4	Zea mays	211-223
31817132-3	2019	Exogenous Tre in the stress treatments increased all of the growth parameters as well as decreased the salinity, low P, and combined stress-mediated Na+/K+, reactive oxygen species (ROS), malondialdehyde (MDA), lipoxygenase (LOX) activity, and methylglyoxal (MG) in both genotypes.	Trehalose	10-13	linoleate 9S-lipoxygenase4	Zea mays	225-228
31817132-6	2019	Interestingly, Tre application enhanced the SOD activity in all the stress treatments but inhibited the POD activity.	Trehalose	15-18	peroxidase 1	Zea mays	104-107
31817132-10	2019	Interestingly, Tre enhanced CAT, APX, GPX, GR, MDHAR, and DHAR activities suggesting the amelioration of ROS scavenging in maize under all the stresses.	Trehalose	15-18	APx1-Cytosolic Ascorbate Peroxidase	Zea mays	33-36
31817132-10	2019	Interestingly, Tre enhanced CAT, APX, GPX, GR, MDHAR, and DHAR activities suggesting the amelioration of ROS scavenging in maize under all the stresses.	Trehalose	15-18	glutathione peroxidase	Zea mays	38-41
31817132-10	2019	Interestingly, Tre enhanced CAT, APX, GPX, GR, MDHAR, and DHAR activities suggesting the amelioration of ROS scavenging in maize under all the stresses.	Trehalose	15-18	glutathione dehydroascorbate reductase2	Zea mays	48-52
31397537-7	2019	To determine why lin-53 and sin-3 mutants die early, we performed transcriptome and metabolomic analysis revealing that levels of the disaccharide trehalose are significantly decreased in both mutants.	Trehalose	147-156	putative histone-binding protein lin-53	Caenorhabditis elegans	17-23
31397537-8	2019	As trehalose is required for normal lifespan in C. elegans, lin-53 and sin-3 mutants could be rescued by either feeding with trehalose or increasing trehalose levels via the insulin/IGF1 signaling pathway.	Trehalose	125-134	Paired amphipathic helix protein sin-3	Caenorhabditis elegans	71-76
31397537-7	2019	To determine why lin-53 and sin-3 mutants die early, we performed transcriptome and metabolomic analysis revealing that levels of the disaccharide trehalose are significantly decreased in both mutants.	Trehalose	147-156	Paired amphipathic helix protein sin-3	Caenorhabditis elegans	28-33
31397537-8	2019	As trehalose is required for normal lifespan in C. elegans, lin-53 and sin-3 mutants could be rescued by either feeding with trehalose or increasing trehalose levels via the insulin/IGF1 signaling pathway.	Trehalose	3-12	putative histone-binding protein lin-53	Caenorhabditis elegans	60-66
31397537-8	2019	As trehalose is required for normal lifespan in C. elegans, lin-53 and sin-3 mutants could be rescued by either feeding with trehalose or increasing trehalose levels via the insulin/IGF1 signaling pathway.	Trehalose	3-12	Paired amphipathic helix protein sin-3	Caenorhabditis elegans	71-76
31397537-8	2019	As trehalose is required for normal lifespan in C. elegans, lin-53 and sin-3 mutants could be rescued by either feeding with trehalose or increasing trehalose levels via the insulin/IGF1 signaling pathway.	Trehalose	125-134	putative histone-binding protein lin-53	Caenorhabditis elegans	60-66
31397537-8	2019	As trehalose is required for normal lifespan in C. elegans, lin-53 and sin-3 mutants could be rescued by either feeding with trehalose or increasing trehalose levels via the insulin/IGF1 signaling pathway.	Trehalose	125-134	Paired amphipathic helix protein sin-3	Caenorhabditis elegans	71-76
31397537-8	2019	As trehalose is required for normal lifespan in C. elegans, lin-53 and sin-3 mutants could be rescued by either feeding with trehalose or increasing trehalose levels via the insulin/IGF1 signaling pathway.	Trehalose	125-134	putative histone-binding protein lin-53	Caenorhabditis elegans	60-66
31659590-0	2019	Human Serum Albumin, a Suitable Candidate to Stabilize Freeze-Dried IgG in Combination with Trehalose: Central Composite Design.	Trehalose	92-101	albumin	Homo sapiens	6-19
31408673-5	2019	It was shown that both trehalose and HP-beta-CD increased the duration of the nucleation phase and slowed down the rate of structural reorganization of the UV-Phb molecule.	Trehalose	23-32	prohibitin 1	Homo sapiens	159-162
31195231-0	2019	Trehalose suppresses cadmium-activated Nrf2 signaling pathway to protect against spleen injury.	Trehalose	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	39-43
31586966-0	2019	Trehalose protects against spinal cord injury through regulating heat shock proteins 27 and 70 and caspase-3 genes expression.	Trehalose	0-9	caspase 3	Rattus norvegicus	99-108
31586966-3	2019	Accordingly, the present study was conducted to investigate the effect of trehalose on spinal expression of HSP27, HSP70 and caspase-3 genes following traumatic spinal cord injury (SCI) in rats.	Trehalose	74-83	heat shock protein family B (small) member 1	Rattus norvegicus	108-113
31586966-3	2019	Accordingly, the present study was conducted to investigate the effect of trehalose on spinal expression of HSP27, HSP70 and caspase-3 genes following traumatic spinal cord injury (SCI) in rats.	Trehalose	74-83	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	115-120
31586966-3	2019	Accordingly, the present study was conducted to investigate the effect of trehalose on spinal expression of HSP27, HSP70 and caspase-3 genes following traumatic spinal cord injury (SCI) in rats.	Trehalose	74-83	caspase 3	Rattus norvegicus	125-134
31586966-8	2019	Trehalose treatment upregulated HSP27, HSP70 genes expression at 1 day after SCI.	Trehalose	0-9	heat shock protein family B (small) member 1	Rattus norvegicus	32-37
31586966-8	2019	Trehalose treatment upregulated HSP27, HSP70 genes expression at 1 day after SCI.	Trehalose	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	39-44
31586966-10	2019	Caspase-3 gene showed a decrease in expression in the trehalose-treated group at all times.	Trehalose	54-63	caspase 3	Rattus norvegicus	0-9
31586966-12	2019	Conclusion This study suggests that the neuroprotective effect of trehalose is mediated via regulation of HSP27 and HSP70, which are involved in cytoprotection and functional recovery following SCI.	Trehalose	66-75	heat shock protein family B (small) member 1	Rattus norvegicus	106-111
31586966-12	2019	Conclusion This study suggests that the neuroprotective effect of trehalose is mediated via regulation of HSP27 and HSP70, which are involved in cytoprotection and functional recovery following SCI.	Trehalose	66-75	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	116-121
31408673-9	2019	Analysis of the combined effect of trehalose and HP-beta-CD on UV-Phb aggregation showed that protein aggregation was independently affected by trehalose and HP-beta-CD.	Trehalose	35-44	prohibitin 1	Homo sapiens	66-69
31408673-9	2019	Analysis of the combined effect of trehalose and HP-beta-CD on UV-Phb aggregation showed that protein aggregation was independently affected by trehalose and HP-beta-CD.	Trehalose	144-153	prohibitin 1	Homo sapiens	66-69
31311032-3	2019	To test whether living mammals preserve molecular evidence of dietary shifts, we examined the trehalase gene (Treh), which encodes an enzyme capable of digesting trehalose from insect blood, in bats and other mammals with diverse diets.	Trehalose	162-171	trehalase	Homo sapiens	94-103
31311032-3	2019	To test whether living mammals preserve molecular evidence of dietary shifts, we examined the trehalase gene (Treh), which encodes an enzyme capable of digesting trehalose from insect blood, in bats and other mammals with diverse diets.	Trehalose	162-171	trehalase	Homo sapiens	110-114
31515484-5	2019	In primary cultured SMCs, TFEB activator trehalose induced nuclear translocation of TFEB and upregulation of TFEB-controlled autophagy genes leading to enhanced autophagy signaling.	Trehalose	41-50	transcription factor EB	Mus musculus	26-30
31519250-9	2019	Sang impaired trehalose hydrolysis, reduced THL activity and transcription, and led to the inhibition of energy metabolism, consequent antigrowth and high lethality in larvae of B. mori.	Trehalose	14-23	trehalase	Bombyx mori	44-47
31522191-0	2019	Trehalose promotes the survival of random-pattern skin flaps by TFEB mediated autophagy enhancement.	Trehalose	0-9	transcription factor EB	Homo sapiens	64-68
31522191-7	2019	Mechanistically, we showed that trehalose"s autophagy augmentation is mediated by activation and nuclear translocation of TFEB, which may be due to inhibition of Akt and activation of the AMPK-SKP2-CARM1 signaling pathway.	Trehalose	32-41	transcription factor EB	Homo sapiens	122-126
31522191-7	2019	Mechanistically, we showed that trehalose"s autophagy augmentation is mediated by activation and nuclear translocation of TFEB, which may be due to inhibition of Akt and activation of the AMPK-SKP2-CARM1 signaling pathway.	Trehalose	32-41	AKT serine/threonine kinase 1	Homo sapiens	162-165
31522191-7	2019	Mechanistically, we showed that trehalose"s autophagy augmentation is mediated by activation and nuclear translocation of TFEB, which may be due to inhibition of Akt and activation of the AMPK-SKP2-CARM1 signaling pathway.	Trehalose	32-41	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	188-192
31522191-7	2019	Mechanistically, we showed that trehalose"s autophagy augmentation is mediated by activation and nuclear translocation of TFEB, which may be due to inhibition of Akt and activation of the AMPK-SKP2-CARM1 signaling pathway.	Trehalose	32-41	S-phase kinase associated protein 2	Homo sapiens	193-197
31522191-7	2019	Mechanistically, we showed that trehalose"s autophagy augmentation is mediated by activation and nuclear translocation of TFEB, which may be due to inhibition of Akt and activation of the AMPK-SKP2-CARM1 signaling pathway.	Trehalose	32-41	coactivator associated arginine methyltransferase 1	Homo sapiens	198-203
31412290-8	2019	RESULTS: Cells treated with trehalose exhibits increased levels of autophagy markers LC3II and LAMP1 compared to untreated cells.	Trehalose	28-37	lysosomal associated membrane protein 1	Homo sapiens	95-100
31412290-9	2019	Trehalose reduced the mRNA and secreted cytokines levels of IL-6, IL-8 and MCP-1 in corneal cells under TNF-alpha and desiccation stress mediated inflammation compared to controls.	Trehalose	0-9	interleukin 6	Mus musculus	60-64
31412290-9	2019	Trehalose reduced the mRNA and secreted cytokines levels of IL-6, IL-8 and MCP-1 in corneal cells under TNF-alpha and desiccation stress mediated inflammation compared to controls.	Trehalose	0-9	chemokine (C-X-C motif) ligand 15	Mus musculus	66-70
31412290-9	2019	Trehalose reduced the mRNA and secreted cytokines levels of IL-6, IL-8 and MCP-1 in corneal cells under TNF-alpha and desiccation stress mediated inflammation compared to controls.	Trehalose	0-9	mast cell protease 1	Mus musculus	75-80
31412290-9	2019	Trehalose reduced the mRNA and secreted cytokines levels of IL-6, IL-8 and MCP-1 in corneal cells under TNF-alpha and desiccation stress mediated inflammation compared to controls.	Trehalose	0-9	tumor necrosis factor	Mus musculus	104-113
31412290-10	2019	Further, trehalose reduced stress driven p38 phosphorylation in corneal cells.	Trehalose	9-18	mitogen-activated protein kinase 14	Homo sapiens	41-44
31515484-5	2019	In primary cultured SMCs, TFEB activator trehalose induced nuclear translocation of TFEB and upregulation of TFEB-controlled autophagy genes leading to enhanced autophagy signaling.	Trehalose	41-50	transcription factor EB	Mus musculus	84-88
31515484-5	2019	In primary cultured SMCs, TFEB activator trehalose induced nuclear translocation of TFEB and upregulation of TFEB-controlled autophagy genes leading to enhanced autophagy signaling.	Trehalose	41-50	transcription factor EB	Mus musculus	84-88
31515484-7	2019	These effects of trehalose were mimicked by ectopic upregulation of TFEB and inhibited by TFEB gene silencing.	Trehalose	17-26	transcription factor EB	Mus musculus	68-72
31515484-7	2019	These effects of trehalose were mimicked by ectopic upregulation of TFEB and inhibited by TFEB gene silencing.	Trehalose	17-26	transcription factor EB	Mus musculus	90-94
31515484-10	2019	Treatment of mice with trehalose reversed this TFEB pathway suppression, and prevented SMC dedifferentiation and HFD-induced neointima formation.	Trehalose	23-32	transcription factor EB	Mus musculus	47-51
31144110-11	2019	In contrast, exogenous trehalose upregulated transcript levels of ABA signaling-related genes, including SlPYL1/3/4/5/6/7/9, SlSnRK2.3/4, SlAREB1/2, and SlDREB1.	Trehalose	23-32	dehydration responsive element binding 1	Solanum lycopersicum	153-160
31477017-4	2019	RESULTS: The loss-of-function mutation of Arabidopsis thaliana TPPF, a member of the TPP gene family, resulted in a drought-sensitive phenotype, while a line overexpressing TPPF showed significantly increased drought tolerance and trehalose accumulation.	Trehalose	231-240	Haloacid dehalogenase-like hydrolase (HAD) superfamily protein	Arabidopsis thaliana	63-67
31477017-4	2019	RESULTS: The loss-of-function mutation of Arabidopsis thaliana TPPF, a member of the TPP gene family, resulted in a drought-sensitive phenotype, while a line overexpressing TPPF showed significantly increased drought tolerance and trehalose accumulation.	Trehalose	231-240	thylakoid processing peptide	Arabidopsis thaliana	63-66
31477017-4	2019	RESULTS: The loss-of-function mutation of Arabidopsis thaliana TPPF, a member of the TPP gene family, resulted in a drought-sensitive phenotype, while a line overexpressing TPPF showed significantly increased drought tolerance and trehalose accumulation.	Trehalose	231-240	Haloacid dehalogenase-like hydrolase (HAD) superfamily protein	Arabidopsis thaliana	173-177
31477017-6	2019	Overexpression of AtTPPF led to increased contents of trehalose, sucrose, and total soluble sugars under drought conditions; these compounds may play a role in scavenging reactive oxygen species.	Trehalose	54-63	Haloacid dehalogenase-like hydrolase (HAD) superfamily protein	Arabidopsis thaliana	18-24
31481932-8	2019	Overexpression of two components of the chaperone assisted selective autophagy (CASA) complex (BAG3 and HSPB8), enhanced ARpolyQ clearance, while the treatment with the mTOR independent autophagy activator trehalose induced complete ARpolyQ degradation.	Trehalose	206-215	mechanistic target of rapamycin kinase	Homo sapiens	169-173
31481932-9	2019	Thus, trehalose has beneficial effects in SBMA skeletal muscle models even when autophagy is impaired, possibly by stimulating CASA to assist the removal of ARpolyQ misfolded species/aggregates.	Trehalose	6-15	androgen receptor	Homo sapiens	42-46
31151997-7	2019	Our results revealed that specific pathways like trehalose-related glycogen metabolism and enzymes such as wax ester synthase/acyl-CoA:diacylglycerol acyltransferase (WS/DGAT) are mainly restricted within specific types of bacterial groups, which provides evolutionary insights into the understanding of their origins and functions.	Trehalose	49-58	diacylglycerol O-acyltransferase 1	Homo sapiens	170-174
31477017-9	2019	These results indicate that, as well as its involvement in regulating trehalose and soluble sugars, AtTPPF is involved in regulating the transcription of stress-responsive genes.	Trehalose	70-79	Haloacid dehalogenase-like hydrolase (HAD) superfamily protein	Arabidopsis thaliana	100-106
31477017-10	2019	CONCLUSION: AtTPPF functions in regulating levels of trehalose, reactive oxygen species, and sucrose levels during drought stress, and the expression of AtTPPF is activated by DREB1A in Arabidopsis.	Trehalose	53-62	Haloacid dehalogenase-like hydrolase (HAD) superfamily protein	Arabidopsis thaliana	12-18
31477017-10	2019	CONCLUSION: AtTPPF functions in regulating levels of trehalose, reactive oxygen species, and sucrose levels during drought stress, and the expression of AtTPPF is activated by DREB1A in Arabidopsis.	Trehalose	53-62	Haloacid dehalogenase-like hydrolase (HAD) superfamily protein	Arabidopsis thaliana	153-159
31477017-10	2019	CONCLUSION: AtTPPF functions in regulating levels of trehalose, reactive oxygen species, and sucrose levels during drought stress, and the expression of AtTPPF is activated by DREB1A in Arabidopsis.	Trehalose	53-62	dehydration response element B1A	Arabidopsis thaliana	176-182
30963238-9	2019	Further, TPS5 knockout reduced the amounts of trehalose and other soluble carbohydrates as well as nitrate reductase (NR) activity.	Trehalose	46-55	trehalose phosphatase/synthase 5	Arabidopsis thaliana	9-13
30963238-10	2019	In vitro, trehalose and other soluble carbohydrates promoted NR activity, which was blocked by the tricarboxylic acid cycle inhibitor iodoacetic acid.	Trehalose	10-19	nitrate reductase 1	Arabidopsis thaliana	61-63
30963238-11	2019	Thus, this study identified that TPS5 functions as a negative regulator of ABA signaling and is involved in altering the trehalose content and NR activity.	Trehalose	121-130	trehalose phosphatase/synthase 5	Arabidopsis thaliana	33-37
31272172-0	2019	Trehalose-induced slowdown of lysozyme hydration dynamics probed by EDLS spectroscopy.	Trehalose	0-9	lysozyme	Homo sapiens	30-38
31346340-10	2019	Furthermore, real-time PCR showed that the expression of Cidea and Ucp1 mRNAs, which are markers for beige adipocytes in the inguinal adipose tissue, increased in the trehalose group.	Trehalose	167-176	cell death-inducing DNA fragmentation factor, alpha subunit-like effector A	Mus musculus	57-62
31346340-10	2019	Furthermore, real-time PCR showed that the expression of Cidea and Ucp1 mRNAs, which are markers for beige adipocytes in the inguinal adipose tissue, increased in the trehalose group.	Trehalose	167-176	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	67-71
31272172-1	2019	We use extended depolarized light scattering spectroscopy to study the dynamics of water in a lysozyme-trehalose aqueous solution over a broad time scale, from hundreds to fractions of picoseconds.	Trehalose	103-112	lysozyme	Homo sapiens	94-102
31272172-3	2019	By comparing aqueous solutions of lysozyme with and without trehalose, we show that the combined action of sugar and protein produces an exceptional dynamic slowdown of a fraction of water molecules around the protein, which become more than twice slower than in the absence of trehalose.	Trehalose	278-287	lysozyme	Homo sapiens	34-42
31475167-12	2019	In vitro study showed that 100 mM trehalose enhanced the expression of M2 macrophage markers (Arg-1 and IL-10), and decreased M1 macrophage polarization through the decreasing expression of IL-6.	Trehalose	34-43	arginase 1	Rattus norvegicus	94-99
31475167-12	2019	In vitro study showed that 100 mM trehalose enhanced the expression of M2 macrophage markers (Arg-1 and IL-10), and decreased M1 macrophage polarization through the decreasing expression of IL-6.	Trehalose	34-43	interleukin 6	Rattus norvegicus	190-194
31475167-12	2019	In vitro study showed that 100 mM trehalose enhanced the expression of M2 macrophage markers (Arg-1 and IL-10), and decreased M1 macrophage polarization through the decreasing expression of IL-6.	Trehalose	34-43	interleukin 10	Rattus norvegicus	104-109
31078265-0	2019	Trehalose intake and exercise upregulate a glucose transporter, GLUT8, in the brain.	Trehalose	0-9	solute carrier family 2, (facilitated glucose transporter), member 8	Mus musculus	64-69
31033580-8	2019	Host and microbial trehalase activity is likely to influence trehalose efficacy in a tissue-dependent manner.	Trehalose	61-70	trehalase	Homo sapiens	19-28
30052167-1	2019	Trehalase catalyses the breakdown of trehalose into two glucose moieties and is ubiquitous in all organisms.	Trehalose	37-46	trehalase	Homo sapiens	0-9
32641951-0	2019	Trehalose Neuroprotective Effects on the Substantia Nigra Dopaminergic Cells by Activating Autophagy and Non-canonical Nrf2 Pathways.	Trehalose	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	119-123
32641951-6	2019	In addition, the antioxidant effects of trehalose were assessed by analyzing the levels of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and also glutathione reductase (GR), glutathione peroxidase (GPx) and Catalase (CAT) enzymes.	Trehalose	40-49	NFE2 like bZIP transcription factor 2	Rattus norvegicus	91-134
32641951-9	2019	Trehalose treatments increased autophagy (high LC3II/LC3I ratio) and the expression of the p62 protein as well.	Trehalose	0-9	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	91-94
32641951-11	2019	In the current study, trehalose simultaneously protects substantia nigra dopaminergic cells by activating both non-canonical p62/SQSTM1-Keap1-Nrf2 and autophagy pathways.	Trehalose	22-31	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	125-128
32641951-11	2019	In the current study, trehalose simultaneously protects substantia nigra dopaminergic cells by activating both non-canonical p62/SQSTM1-Keap1-Nrf2 and autophagy pathways.	Trehalose	22-31	sequestosome 1	Rattus norvegicus	129-135
32641951-11	2019	In the current study, trehalose simultaneously protects substantia nigra dopaminergic cells by activating both non-canonical p62/SQSTM1-Keap1-Nrf2 and autophagy pathways.	Trehalose	22-31	Kelch-like ECH-associated protein 1	Rattus norvegicus	136-141
32641951-11	2019	In the current study, trehalose simultaneously protects substantia nigra dopaminergic cells by activating both non-canonical p62/SQSTM1-Keap1-Nrf2 and autophagy pathways.	Trehalose	22-31	NFE2 like bZIP transcription factor 2	Rattus norvegicus	142-146
31078265-5	2019	Consistent with the results of previous studies, our biochemical analyses demonstrated that trehalose increased the level of lipidated LC3 (LC3II) in the brain and liver of adult mice.	Trehalose	92-101	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	135-138
31078265-5	2019	Consistent with the results of previous studies, our biochemical analyses demonstrated that trehalose increased the level of lipidated LC3 (LC3II) in the brain and liver of adult mice.	Trehalose	92-101	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	140-145
31078265-8	2019	Moreover, the trehalose transporter GLUT8 was increased in the liver by trehalose or in the brain by trehalose together with exercise.	Trehalose	14-23	solute carrier family 2, (facilitated glucose transporter), member 8	Mus musculus	36-41
31078265-8	2019	Moreover, the trehalose transporter GLUT8 was increased in the liver by trehalose or in the brain by trehalose together with exercise.	Trehalose	72-81	solute carrier family 2, (facilitated glucose transporter), member 8	Mus musculus	36-41
30513271-0	2019	Trehalose attenuates spinal cord injury through the regulation of oxidative stress, inflammation and GFAP expression in rats.	Trehalose	0-9	glial fibrillary acidic protein	Rattus norvegicus	101-105
31147454-0	2019	Trehalose: is it a potential inhibitor of antithrombin polymerization?	Trehalose	0-9	serpin family C member 1	Homo sapiens	42-54
31147454-7	2019	Rep (2019) 5, 39] studies the role of trehalose in the prevention of the polymerization of antithrombin, which belongs to the serpin superfamily.	Trehalose	38-47	serpin family C member 1	Homo sapiens	91-103
31147454-9	2019	The authors demonstrate that trehalose is able to prevent the in vitro polymerization of antithrombin, under conditions in which it usually tends to polymerize, and demonstrate it by using different techniques.	Trehalose	29-38	serpin family C member 1	Homo sapiens	89-101
31147454-10	2019	However, the binding site of trehalose in antithrombin should be defined by site-directed mutagenesis.	Trehalose	29-38	serpin family C member 1	Homo sapiens	42-54
30864262-9	2019	In addition, long-term exercise showed more significant effects on activation of lysosomes biogenesis compared with the short-term exercise and trehalose, a classical autophagy activator in the mTOR-independent pathway.	Trehalose	144-153	mechanistic target of rapamycin kinase	Mus musculus	194-198
31068436-0	2019	An Ssd1 Homolog Impacts Trehalose and Chitin Biosynthesis and Contributes to Virulence in Aspergillus fumigatus.	Trehalose	24-33	mRNA-binding translational repressor SSD1	Saccharomyces cerevisiae S288C	3-7
31068436-3	2019	In this study, we observed that a yeast ssd1 homolog, ssdA, in the filamentous fungus Aspergillus fumigatus is involved in trehalose and cell wall homeostasis.	Trehalose	123-132	mRNA-binding translational repressor SSD1	Saccharomyces cerevisiae S288C	40-44
30513271-9	2019	Moreover, trehalose reduced GFAP expression as soon as 1-day post-trauma.	Trehalose	10-19	glial fibrillary acidic protein	Rattus norvegicus	28-32
30628830-1	2019	Neutral trehalase 1 (Nth1) from Saccharomyces cerevisiae catalyzes disaccharide trehalose hydrolysis and helps yeast to survive adverse conditions, such as heat shock, starvation or oxidative stress.	Trehalose	80-89	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	0-19
30690513-5	2019	The ChIP-qPCR and transient dual-luciferase reporter assays indicated that ANAC032 regulates trehalose metabolism via the direct regulation of TRE1 expression.	Trehalose	93-102	NAC domain containing protein 32	Arabidopsis thaliana	75-82
30690513-5	2019	The ChIP-qPCR and transient dual-luciferase reporter assays indicated that ANAC032 regulates trehalose metabolism via the direct regulation of TRE1 expression.	Trehalose	93-102	trehalase 1	Arabidopsis thaliana	143-147
30628830-1	2019	Neutral trehalase 1 (Nth1) from Saccharomyces cerevisiae catalyzes disaccharide trehalose hydrolysis and helps yeast to survive adverse conditions, such as heat shock, starvation or oxidative stress.	Trehalose	80-89	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	21-25
30979854-0	2019	Withdrawal: Yeast tolerance to various stresses relies on the trehalose-6P synthase (Tps1) protein, not on trehalose.	Trehalose	62-71	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	85-89
31035710-1	2019	Trehalose (TRE), a disaccharide, is absorbed slowly and gradually increases the blood glucose (GLU) level along with reducing insulin secretion.	Trehalose	0-9	trehalase	Homo sapiens	11-14
31061988-4	2019	When IL-4 was coloaded with BSA for stabilization, we saw increased IL-4 bioactivity compared to no added stabilization, trehalose stabilization, or murine serum albumin stabilization.	Trehalose	121-130	interleukin 4	Homo sapiens	5-9
31013754-4	2019	Considering these premises, in this study we have analyzed different mTOR-independent inducers, reporting that the disaccharide trehalose, a mTOR-independent autophagy activator, rescued the autophagy flux in Caco-2 cells treated with digested gliadin, as well as improved cell viability.	Trehalose	128-137	mechanistic target of rapamycin kinase	Homo sapiens	69-73
31013754-4	2019	Considering these premises, in this study we have analyzed different mTOR-independent inducers, reporting that the disaccharide trehalose, a mTOR-independent autophagy activator, rescued the autophagy flux in Caco-2 cells treated with digested gliadin, as well as improved cell viability.	Trehalose	128-137	mechanistic target of rapamycin kinase	Homo sapiens	141-145
30923567-9	2019	Strikingly, physiological impacts of the superior parent alleles of VPS34, VID24 and DAP1 converged on cell membrane by increasing trehalose accumulation or reducing membrane fluidity.	Trehalose	131-140	phosphatidylinositol 3-kinase VPS34	Saccharomyces cerevisiae S288C	68-73
30886063-0	2019	Deciphering the role of trehalose in hindering antithrombin polymerization.	Trehalose	24-33	serpin family C member 1	Homo sapiens	47-59
30886063-6	2019	Of these, trehalose proved to be most promising as it showed a marked decrease in the bead like polymeric structures of AT shown by electron microscopic analysis.	Trehalose	10-19	serpin family C member 1	Homo sapiens	120-122
30886063-7	2019	A circular dichroism (CD) analysis indicated alteration in the secondary structure profile and an increased thermal stability of AT in the presence of trehalose.	Trehalose	151-160	serpin family C member 1	Homo sapiens	129-131
30886063-8	2019	Guanidine hydrochloride (GdnHCl)-based unfolding studies of AT show the formation of a different intermediate in the presence of trehalose.	Trehalose	129-138	serpin family C member 1	Homo sapiens	60-62
30886063-9	2019	A time-dependent fluorescence study using 1,1"-bi(4-anilino)naphthalene-5,5"-disulfonic acid (Bis-ANS) shows that trehalose affects the initial conformational change step in transition from native to polymer state through its binding to exposed hydrophobic residues on AT thus making AT less polymerogenic.	Trehalose	114-123	serpin family C member 1	Homo sapiens	269-271
30886063-9	2019	A time-dependent fluorescence study using 1,1"-bi(4-anilino)naphthalene-5,5"-disulfonic acid (Bis-ANS) shows that trehalose affects the initial conformational change step in transition from native to polymer state through its binding to exposed hydrophobic residues on AT thus making AT less polymerogenic.	Trehalose	114-123	serpin family C member 1	Homo sapiens	284-286
30335591-0	2019	Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.	Trehalose	0-9	transcription factor EB	Homo sapiens	51-55
30335591-3	2019	The natural compound trehalose promotes autophagy via TFEB (transcription factor EB), ameliorating disease phenotype in multiple ND models, but its mechanism is still obscure.	Trehalose	21-30	transcription factor EB	Homo sapiens	54-58
30335591-3	2019	The natural compound trehalose promotes autophagy via TFEB (transcription factor EB), ameliorating disease phenotype in multiple ND models, but its mechanism is still obscure.	Trehalose	21-30	transcription factor EB	Homo sapiens	60-83
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	transcription factor EB	Homo sapiens	36-40
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	PPARG coactivator 1 alpha	Homo sapiens	62-70
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	cathepsin B	Homo sapiens	116-120
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	galactosidase alpha	Homo sapiens	122-125
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	mucolipin TRP cation channel 1	Homo sapiens	135-141
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	tripeptidyl peptidase 1	Homo sapiens	143-147
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	beclin 1	Homo sapiens	191-196
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	autophagy related 10	Homo sapiens	198-203
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	autophagy related 12	Homo sapiens	205-210
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	sequestosome 1	Homo sapiens	212-218
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	sequestosome 1	Homo sapiens	219-222
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	microtubule associated protein 1 light chain 3 beta	Homo sapiens	224-232
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	heat shock protein family B (small) member 8	Homo sapiens	234-239
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	BAG cochaperone 3	Homo sapiens	244-248
30335591-6	2019	Trehalose upregulated genes for the TFEB target and regulator Ppargc1a, lysosomal hydrolases and membrane proteins (Ctsb, Gla, Lamp2a, Mcoln1, Tpp1) and several autophagy-related components (Becn1, Atg10, Atg12, Sqstm1/p62, Map1lc3b, Hspb8 and Bag3) mostly in a PPP3- and TFEB-dependent manner.	Trehalose	0-9	transcription factor EB	Homo sapiens	272-276
30335591-7	2019	TFEB silencing counteracted the trehalose pro-degradative activity on misfolded protein causative of motoneuron diseases.	Trehalose	32-41	transcription factor EB	Homo sapiens	0-4
30335591-8	2019	Similar effects were exerted by trehalase-resistant trehalose analogs, melibiose and lactulose.	Trehalose	52-61	trehalase	Homo sapiens	32-41
30058771-0	2019	Trehalose phosphate synthase 5-dependent trehalose metabolism modulates basal defense responses in Arabidopsis thaliana.	Trehalose	41-50	trehalose phosphatase/synthase 5	Arabidopsis thaliana	0-30
30058771-2	2019	In this study, we demonstrate that TREHALOSE PHOSPHATE SYNTHASE 5 (TPS5)-dependent trehalose metabolism regulates Arabidopsis thaliana defenses against pathogens (necrotrophic Botrytis cinerea and biotrophic Pseudomonas syringae).	Trehalose	83-92	trehalose phosphatase/synthase 5	Arabidopsis thaliana	35-65
30058771-2	2019	In this study, we demonstrate that TREHALOSE PHOSPHATE SYNTHASE 5 (TPS5)-dependent trehalose metabolism regulates Arabidopsis thaliana defenses against pathogens (necrotrophic Botrytis cinerea and biotrophic Pseudomonas syringae).	Trehalose	83-92	trehalose phosphatase/synthase 5	Arabidopsis thaliana	67-71
30058771-5	2019	We demonstrate that elevated trehalose biosynthesis, in transgenic plants over-expressing TPS5, also increased the susceptibility to P. syringae, but decreased the disease symptoms caused by B. cinerea.	Trehalose	29-38	trehalose phosphatase/synthase 5	Arabidopsis thaliana	90-94
30058771-6	2019	The knockout of TPS5 prevented the accumulation of trehalose and enhanced defense responses against P. syringae.	Trehalose	51-60	trehalose phosphatase/synthase 5	Arabidopsis thaliana	16-20
30058771-9	2019	These findings provide insight into the function of TPS5-dependent trehalose metabolism in plant basal defense responses.	Trehalose	67-76	trehalose phosphatase/synthase 5	Arabidopsis thaliana	52-56
30704318-0	2019	Inhibition of inhaled halloysite nanotube toxicity by trehalose through enhanced autophagic clearance of p62.	Trehalose	54-63	sequestosome 1	Mus musculus	105-108
30704318-6	2019	We found that p62 can be eliminated by trehalose and the application of trehalose in vitro and in vivo successfully inhibits toxicity by accelerating the clearance of p62.	Trehalose	39-48	sequestosome 1	Mus musculus	14-17
30704318-6	2019	We found that p62 can be eliminated by trehalose and the application of trehalose in vitro and in vivo successfully inhibits toxicity by accelerating the clearance of p62.	Trehalose	72-81	sequestosome 1	Mus musculus	14-17
30704318-6	2019	We found that p62 can be eliminated by trehalose and the application of trehalose in vitro and in vivo successfully inhibits toxicity by accelerating the clearance of p62.	Trehalose	72-81	sequestosome 1	Mus musculus	167-170
30925684-0	2019	The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice.	Trehalose	17-26	apolipoprotein E	Mus musculus	71-87
30925684-5	2019	The aim of our study was to comprehensively describe the influence of a prolonged treatment with orally administered trehalose on the development of atherosclerotic lesions and hepatic steatosis in apolipoprotein E knockout (apoE-/-) mice in an experimental set up reflecting both moderate and severe proatherogenic conditions: male apoE-/- mice on a chow diet (CD) and female apoE-/- mice fed with a high-fat diet (HFD).	Trehalose	117-126	apolipoprotein E	Mus musculus	198-214
30925684-5	2019	The aim of our study was to comprehensively describe the influence of a prolonged treatment with orally administered trehalose on the development of atherosclerotic lesions and hepatic steatosis in apolipoprotein E knockout (apoE-/-) mice in an experimental set up reflecting both moderate and severe proatherogenic conditions: male apoE-/- mice on a chow diet (CD) and female apoE-/- mice fed with a high-fat diet (HFD).	Trehalose	117-126	apolipoprotein E	Mus musculus	225-233
30925684-5	2019	The aim of our study was to comprehensively describe the influence of a prolonged treatment with orally administered trehalose on the development of atherosclerotic lesions and hepatic steatosis in apolipoprotein E knockout (apoE-/-) mice in an experimental set up reflecting both moderate and severe proatherogenic conditions: male apoE-/- mice on a chow diet (CD) and female apoE-/- mice fed with a high-fat diet (HFD).	Trehalose	117-126	apolipoprotein E	Mus musculus	225-229
30925684-5	2019	The aim of our study was to comprehensively describe the influence of a prolonged treatment with orally administered trehalose on the development of atherosclerotic lesions and hepatic steatosis in apolipoprotein E knockout (apoE-/-) mice in an experimental set up reflecting both moderate and severe proatherogenic conditions: male apoE-/- mice on a chow diet (CD) and female apoE-/- mice fed with a high-fat diet (HFD).	Trehalose	117-126	apolipoprotein E	Mus musculus	333-337
30925684-6	2019	We found that exogenous trehalose inhibited atherosclerosis and attenuated hepatic steatosis in apoE-/- mice.	Trehalose	24-33	apolipoprotein E	Mus musculus	96-100
30962478-4	2019	Arg2 is upregulated in fasting conditions and upon treatment with the hepatocyte glucose transporter inhibitor trehalose.	Trehalose	111-120	arginase type II	Mus musculus	0-4
30769031-4	2019	Trehalose effectively reversed high glucose-suppressed autophagy and reduced p62 protein expression.	Trehalose	0-9	nucleoporin 62	Mus musculus	77-80
30941102-1	2019	Bombyxin-II, an insulin-like peptide of the silkmoth Bombyx mori, has been shown to reduce both the trehalose concentration in the hemolymph and the glycogen content in some tissues of B. mori larvae.	Trehalose	100-109	bombyxin A-6	Bombyx mori	0-11
30941102-1	2019	Bombyxin-II, an insulin-like peptide of the silkmoth Bombyx mori, has been shown to reduce both the trehalose concentration in the hemolymph and the glycogen content in some tissues of B. mori larvae.	Trehalose	100-109	insulin-like peptide	Bombyx mori	16-36
30923567-9	2019	Strikingly, physiological impacts of the superior parent alleles of VPS34, VID24 and DAP1 converged on cell membrane by increasing trehalose accumulation or reducing membrane fluidity.	Trehalose	131-140	glucose-induced degradation complex subunit VID24	Saccharomyces cerevisiae S288C	75-80
30923567-9	2019	Strikingly, physiological impacts of the superior parent alleles of VPS34, VID24 and DAP1 converged on cell membrane by increasing trehalose accumulation or reducing membrane fluidity.	Trehalose	131-140	Dap1p	Saccharomyces cerevisiae S288C	85-89
30523449-1	2019	Maltooligosyl trehalose trehalohydrolase (MTHase, EC 3.2.1.141) catalyzes the release of trehalose, a novel food ingredient, by splitting the alpha-1,4-glucosidic linkage adjacent to the alpha-1,1-glucosidic linkage of maltooligosyl trehalose.	Trehalose	89-98	ATZ20_RS02385	Sulfolobus acidocaldarius	0-40
30385314-1	2019	Trehalose-6-phosphate synthase (TPS) is responsible for synthesizing trehalose, which is prevalent in crustaceans and insects as blood-sugar.	Trehalose	69-78	alpha,alpha-trehalose-phosphate synthase	Musca domestica	0-30
30599315-0	2019	Trehalose prevents cadmium-induced hepatotoxicity by blocking Nrf2 pathway, restoring autophagy and inhibiting apoptosis.	Trehalose	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	62-66
30385314-1	2019	Trehalose-6-phosphate synthase (TPS) is responsible for synthesizing trehalose, which is prevalent in crustaceans and insects as blood-sugar.	Trehalose	69-78	alpha,alpha-trehalose-phosphate synthase	Musca domestica	32-35
30582934-8	2019	The results revealed the additive effect of the combined treatment with rapamycin and trehalose on dopaminergic deficits (according to the levels of TH expression in the nigrostriatal system) but not on the behavioral performance in the mouse PD model.	Trehalose	86-95	tyrosine hydroxylase	Mus musculus	149-151
30617946-0	2019	The effects of trehalose glycolipid presentation on cytokine production by GM-CSF macrophages.	Trehalose	15-24	colony stimulating factor 2	Homo sapiens	75-81
30828477-4	2019	Trehalase is an intrinsic glycoprotein of the small intestine and kidney that transports trehalose and hydrolyses it to two glucose molecules.	Trehalose	89-98	trehalase	Homo sapiens	0-9
30679445-0	2019	Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose.	Trehalose	111-120	synuclein alpha	Homo sapiens	25-40
31538882-10	2019	CONCLUSION: These data suggest that the autophagy inducer trehalose rescued against insulin resistance-induced kidney and skeletal muscle injury, apoptosis and excessive autophagy, possibly in association with restored mTOR phosphorylation without affecting Akt.	Trehalose	58-67	mechanistic target of rapamycin kinase	Mus musculus	219-223
30472065-7	2019	The relative abundance of the CYP19 mRNA in frozen-thawed bGCs was greater in the groups containing 0.2, 0.4 and 0.6 mol/L trehalose, and relative abundances of FSHR and BCL2 mRNA were greater in the group of bGCs treated with 0.2 mol/L trehalose (P&lt;0.05).	Trehalose	123-132	aromatase	Bos taurus	30-35
30472065-7	2019	The relative abundance of the CYP19 mRNA in frozen-thawed bGCs was greater in the groups containing 0.2, 0.4 and 0.6 mol/L trehalose, and relative abundances of FSHR and BCL2 mRNA were greater in the group of bGCs treated with 0.2 mol/L trehalose (P&lt;0.05).	Trehalose	237-246	aromatase	Bos taurus	30-35
30472065-8	2019	Trehalose treatment at 0.4, 0.6 and 0.8 mol/L had an inhibitory effect on BAX gene transcription in frozen-thawed bGCs (P&lt;0.05).	Trehalose	0-9	BCL2 associated X, apoptosis regulator	Bos taurus	74-77
31538882-4	2019	Akt2 knockout (Akt2-/-) and adult WT mice were treated with trehalose (1 mg/g/d) intraperitoneally for 2 days, followed by providing 2% trehalose in drinking water for 2 months.	Trehalose	60-69	thymoma viral proto-oncogene 2	Mus musculus	0-4
31538882-10	2019	CONCLUSION: These data suggest that the autophagy inducer trehalose rescued against insulin resistance-induced kidney and skeletal muscle injury, apoptosis and excessive autophagy, possibly in association with restored mTOR phosphorylation without affecting Akt.	Trehalose	58-67	thymoma viral proto-oncogene 2	Mus musculus	258-261
31538882-7	2019	RESULTS: Akt2 ablation impaired glucose tolerance, promoted protein carbonyl formation and decreased aconitase activity in kidney and skeletal muscles, associated with pronounced apoptosis and overt autophagy, the effects of which, with the exception of IPGTT, were greatly ameliorated or negated by trehalose treatment.	Trehalose	300-309	thymoma viral proto-oncogene 2	Mus musculus	9-13
31538882-8	2019	Moreover, phosphorylation of mTOR was downregulated in both kidney and skeletal muscles from Akt2-/- mice, the effect of which was attenuated by trehalose.	Trehalose	145-154	mechanistic target of rapamycin kinase	Mus musculus	29-33
31538882-8	2019	Moreover, phosphorylation of mTOR was downregulated in both kidney and skeletal muscles from Akt2-/- mice, the effect of which was attenuated by trehalose.	Trehalose	145-154	thymoma viral proto-oncogene 2	Mus musculus	93-97
30461273-0	2018	Restoration of Myoglobin Native Fold from Its Initial State of Amyloid Formation by Trehalose.	Trehalose	84-93	myoglobin	Homo sapiens	15-24
31235159-6	2019	Studies have shown that trehalose can significantly modulate insulin sensitivity via at least 7 molecular pathways leading to better control of hyperglycemia.	Trehalose	24-33	insulin	Homo sapiens	61-68
30811129-15	2019	The occurrence of A allele in the rs2276064 locus of TREH gene (trehalose intolerance; 31.3-58.9% in northerners, 1.9% in Europeans) increases the probability of the onset of type 2 diabetes mellitus.	Trehalose	64-73	trehalase	Homo sapiens	53-57
30990119-6	2019	Dramatically increase in EPO expression in conjugated linoleic acid, spermidine, trehalose, and maltose (19, 20, 16, and 19-fold, respectively) did not increase erythropoietin productivity, but betaine which did not caused ER expansion, with minor increase in EPO gene expression increase EPO productivity.	Trehalose	81-90	erythropoietin	Cricetulus griseus	25-28
30461273-4	2018	This study focuses on the restoration of acid-denatured amyloid transition of myoglobin by trehalose.	Trehalose	91-100	myoglobin	Homo sapiens	78-87
30461273-6	2018	We found that acid-denatured myoglobin at an initial process of amyloidogenic reaction (helix-to-sheet transition followed by oligomerization) at 25  C was substantially restored to its native structure by trehalose.	Trehalose	206-215	myoglobin	Homo sapiens	29-38
30461273-9	2018	Therefore, the present results suggest that trehalose will restore the tightly bound water molecules around the hotspot (G-helix) of myoglobin on the amyloid transition by its intrinsic preservative action of the native hydration shell against denaturation.	Trehalose	44-53	myoglobin	Homo sapiens	133-142
30036838-7	2018	The abundant expression of heat shock protein genes (HSP12, HSP10 and SSC1) and genes related to trehalose synthesis (TPS1 and TSL1) induced by salt stress protected yeast cells against complex stress conditions, contributing to the improved cadmium tolerance.	Trehalose	97-106	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	118-122
30463673-6	2018	The ~10 mus and ~150 mus components in both liquid and trehalose-embedded PS I were assigned to recombination between A1B- and P700+ and between A1A- and P700+, respectively.	Trehalose	55-64	alpha-1-B glycoprotein	Homo sapiens	118-121
30463673-7	2018	The kinetics and amplitudes of these resolved kinetic phases in liquid and trehalose-embedded PS I samples could be well-fitted by a kinetic model that allowed us to calculate the asymmetrical contribution of the A1A- and A1B- quinones to the electrochromic signal at 480 nm.	Trehalose	75-84	alpha-1-B glycoprotein	Homo sapiens	222-225
30619489-10	2018	On the contrary, NDT1 overexpression brings about on the one hand, a decrease in the respiratory efficiency generating harmful superoxide anions, and on the other, a decrease in gluconeogenesis and trehalose stores: all this is reflected into a time-dependent loss of mitochondrial functionality during chronological aging.	Trehalose	198-207	NAD+ transporter	Saccharomyces cerevisiae S288C	17-21
30315929-0	2018	Microglial overexpression of fALS-linked mutant SOD1 induces SOD1 processing impairment, activation and neurotoxicity and is counteracted by the autophagy inducer trehalose.	Trehalose	163-172	superoxide dismutase 1	Rattus norvegicus	48-52
30315929-6	2018	Treatment with the autophagy-inducer trehalose reduced mutant SOD1 accumulation in microglial cells, decreased microglial activation and abrogated neurotoxicity in the co-culture model.	Trehalose	37-46	superoxide dismutase 1	Rattus norvegicus	62-66
30315929-7	2018	These data suggest that i) the alteration of the autophagic pathway due to mutant SOD1 overexpression is involved in microglial activation and neurotoxicity; ii) the induction of autophagy with trehalose reduces microglial SOD1 accumulation through proteasome degradation and activation, leading to neuroprotection.	Trehalose	194-203	superoxide dismutase 1	Rattus norvegicus	82-86
30315929-7	2018	These data suggest that i) the alteration of the autophagic pathway due to mutant SOD1 overexpression is involved in microglial activation and neurotoxicity; ii) the induction of autophagy with trehalose reduces microglial SOD1 accumulation through proteasome degradation and activation, leading to neuroprotection.	Trehalose	194-203	superoxide dismutase 1	Rattus norvegicus	223-227
30273665-10	2018	The trehalose/pullulan ratio had no impact on the stability of lysozyme, while the stability of beta-galactosidase increased with increasing trehalose/pullulan ratios.	Trehalose	141-150	galactosidase beta 1	Homo sapiens	96-114
30267881-7	2018	Interestingly, v6 Fab-PLGA NPs cryopreserved in 10% trehalose and stored maintained specific cell binding.	Trehalose	52-61	FA complementation group B	Homo sapiens	18-21
30036838-7	2018	The abundant expression of heat shock protein genes (HSP12, HSP10 and SSC1) and genes related to trehalose synthesis (TPS1 and TSL1) induced by salt stress protected yeast cells against complex stress conditions, contributing to the improved cadmium tolerance.	Trehalose	97-106	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	127-131
30386789-1	2018	The yeast trehalose-6-phosphate synthase (Tps1) catalyzes the formation of trehalose-6-phosphate (T6P) in trehalose synthesis.	Trehalose	10-19	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	42-46
30140075-6	2018	While the treatment of control cells with either compound C or trehalose induces activation of autophagosomes as well as autolysosomes, the treatment of AMPK alpha1 knockout cells with compound C or trehalose induces mainly activation of autophagosomes, but not autolysosomes.	Trehalose	199-208	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	153-164
30266908-6	2018	We demonstrate that the three chemical chaperones 4-phenylbutyrate, sorbitol, and trehalose reverse the deficits caused by mutations in Munc18-1 in vitro and in vivo in multiple models, offering a novel strategy for the treatment of varied encephalopathies.	Trehalose	82-91	syntaxin binding protein 1	Mus musculus	136-144
30184196-4	2018	The inactivation of gadC gene in L. acidophilus NCFM significantly reduced bacterial viability at pH 2.0, and diminished the protective effect of trehalose against acid stress.	Trehalose	146-155	amino acid permease	Lactobacillus acidophilus NCFM	20-24
30007297-0	2018	The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1.	Trehalose	4-13	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	99-103
30007297-0	2018	The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1.	Trehalose	4-13	alpha-glucoside permease	Saccharomyces cerevisiae S288C	108-112
30007297-2	2018	It was not known yet how trehalose, synthesized in the cytosol when dividing Saccharomyces cerevisiae cells are shifted from 28 C to 40 C, is transported to the outside and degraded when cells return to 28 C. According to our results, the lack of Agt1, a trehalose transporter, although had not affected trehalose synthesis, reduced cell tolerance to 51 C and increased lipid peroxidation.	Trehalose	25-34	alpha-glucoside permease	Saccharomyces cerevisiae S288C	247-251
30007297-5	2018	This suggests that Agt1 containing vesicles would fuse with the membrane under 40 C to transport part of the cytosolic trehalose to the outside.	Trehalose	119-128	alpha-glucoside permease	Saccharomyces cerevisiae S288C	19-23
30007297-6	2018	By a similar mechanism, Ath1 would reach the cell surface to hydrolyze the external trehalose but only when the stress would be over.	Trehalose	84-93	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	24-28
30007297-7	2018	Corroborating this conclusion, Ath1 activity in soluble cell-free extracts increased after 40 C adaptation but decreased when cells returned to 28 C. During 40 C, Ath1 is confined into vesicles, avoiding the cleavage of the outside trehalose.	Trehalose	232-241	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	31-35
30197596-8	2018	We have revealed that the dilp2 mutation led to a drop in glycogen levels independently on diet, lack of dilp3 led to dramatic increase in circulating trehalose and glycogen levels, especially at low protein consumption.	Trehalose	151-160	Insulin-like peptide 3	Drosophila melanogaster	105-110
30135298-4	2018	We show that Aloxe3 is activated during fasting, glucose withdrawal, or trehalose/trehalose analogue treatment.	Trehalose	72-81	arachidonate lipoxygenase 3	Mus musculus	13-19
30135298-4	2018	We show that Aloxe3 is activated during fasting, glucose withdrawal, or trehalose/trehalose analogue treatment.	Trehalose	82-91	arachidonate lipoxygenase 3	Mus musculus	13-19
29860440-6	2018	Under in vitro conditions, trehalose is able to restore the GdHCl-induced loss of ATPase activity of recombinant Hsp104 to almost its original level.	Trehalose	27-36	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	113-119
30166521-6	2018	We selected the mTOR-independent disaccharide trehalose and the mTOR-dependent macrolide lactone rapamycin autophagy inducers.	Trehalose	46-55	mechanistic target of rapamycin kinase	Homo sapiens	16-20
30166521-7	2018	In castration-resistant PC (CRPC) PC3 cells, trehalose specifically prevented intrinsic apoptosis in docetaxel-treated cells.	Trehalose	45-54	keratin 6A	Homo sapiens	34-37
30166521-8	2018	Trehalose reduced the release of cytochrome c triggered by docetaxel and the formation of aberrant mitochondria, possibly by enhancing the turnover of damaged mitochondria via autophagy (mitophagy).	Trehalose	0-9	cytochrome c, somatic	Homo sapiens	33-45
30166521-9	2018	In fact, trehalose increased LC3 and p62 expression, LC3-II and p62 (p62 bodies) accumulation and the induction of LC3 puncta.	Trehalose	9-18	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	29-32
30166521-9	2018	In fact, trehalose increased LC3 and p62 expression, LC3-II and p62 (p62 bodies) accumulation and the induction of LC3 puncta.	Trehalose	9-18	nucleoporin 62	Homo sapiens	37-40
30166521-9	2018	In fact, trehalose increased LC3 and p62 expression, LC3-II and p62 (p62 bodies) accumulation and the induction of LC3 puncta.	Trehalose	9-18	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	53-56
30166521-9	2018	In fact, trehalose increased LC3 and p62 expression, LC3-II and p62 (p62 bodies) accumulation and the induction of LC3 puncta.	Trehalose	9-18	nucleoporin 62	Homo sapiens	64-67
30166521-9	2018	In fact, trehalose increased LC3 and p62 expression, LC3-II and p62 (p62 bodies) accumulation and the induction of LC3 puncta.	Trehalose	9-18	nucleoporin 62	Homo sapiens	64-67
30166521-9	2018	In fact, trehalose increased LC3 and p62 expression, LC3-II and p62 (p62 bodies) accumulation and the induction of LC3 puncta.	Trehalose	9-18	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	53-56
30166521-10	2018	In docetaxel-treated cells, trehalose, but not rapamycin, determined a perinuclear mitochondrial aggregation (mito-aggresomes), and mitochondria specifically colocalized with LC3 and p62-positive autophagosomes.	Trehalose	28-37	nucleoporin 62	Homo sapiens	183-186
30138481-11	2018	Furthermore, trehalose, which has no effect on the ASR1 structure by itself, showed a synergistic effect on the ASR1-driven heat shock protection towards the reporter enzyme citrate synthase (CS).	Trehalose	13-22	abscisic stress-ripening protein 1	Solanum lycopersicum	51-55
30138481-11	2018	Furthermore, trehalose, which has no effect on the ASR1 structure by itself, showed a synergistic effect on the ASR1-driven heat shock protection towards the reporter enzyme citrate synthase (CS).	Trehalose	13-22	abscisic stress-ripening protein 1	Solanum lycopersicum	112-116
30050282-0	2018	Trehalose/hyaluronate eyedrop effects on ocular surface inflammatory markers and mucin expression in dry eye patients.	Trehalose	0-9	LOC100508689	Homo sapiens	81-86
29781274-1	2018	The macrophage inducible C-type lectin (Mincle) is a pattern recognition receptor that recognizes trehalose dimycolate (TDM), and trehalose dibehenate (TDB) and related trehalose diesters, and thus represents a promising target for the development of vaccine adjuvants based on the trehalose glycolipid scaffold.	Trehalose	98-107	C-type lectin domain family 4 member E	Homo sapiens	4-38
29781274-1	2018	The macrophage inducible C-type lectin (Mincle) is a pattern recognition receptor that recognizes trehalose dimycolate (TDM), and trehalose dibehenate (TDB) and related trehalose diesters, and thus represents a promising target for the development of vaccine adjuvants based on the trehalose glycolipid scaffold.	Trehalose	98-107	C-type lectin domain family 4 member E	Homo sapiens	40-46
30050282-1	2018	Aim: To assess the ocular surface parameters, inflammatory marker level in tears, and mucin expression in conjunctival epithelium before and after treatment with trehalose/hyaluronate tear substitute in dry eye (DE) patients.	Trehalose	162-171	LOC100508689	Homo sapiens	86-91
29555437-3	2018	Trehalose, mannitol and xylitol were used as drug carriers with the aim to preserve insulin integrity and stability but also to facilitate rapid release rates.	Trehalose	0-9	insulin	Homo sapiens	84-91
30016968-10	2018	Moreover, both rapamycin and trehalose attenuated the enhanced Ube2v1-mediated lung metastasis by inducing the autophagy pathway in an orthotropic mouse xenograft model of lung metastasis.	Trehalose	29-38	ubiquitin-conjugating enzyme E2 variant 1	Mus musculus	63-69
30127837-12	2018	The levels of p62 protein, were increased in the cells under H2O2 treatment, while the levels of p62 protein in the cytoplasm, as autophagy inclusions, reduced for the group with trehalose pre-treatment.	Trehalose	179-188	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	14-17
30127837-12	2018	The levels of p62 protein, were increased in the cells under H2O2 treatment, while the levels of p62 protein in the cytoplasm, as autophagy inclusions, reduced for the group with trehalose pre-treatment.	Trehalose	179-188	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	97-100
29383655-0	2018	Autophagic Modulation by Trehalose Reduces Accumulation of TDP-43 in a Cell Model of Amyotrophic Lateral Sclerosis via TFEB Activation.	Trehalose	25-34	TAR DNA binding protein	Homo sapiens	59-65
29383655-0	2018	Autophagic Modulation by Trehalose Reduces Accumulation of TDP-43 in a Cell Model of Amyotrophic Lateral Sclerosis via TFEB Activation.	Trehalose	25-34	transcription factor EB	Homo sapiens	119-123
29383655-6	2018	Here we examined the effect of trehalose on TDP-43 clearance in a cell culture model and identified that trehalose treatment significantly reduced TDP-43 accumulation in vitro through modulation of the autophagic degradation pathway.	Trehalose	105-114	TAR DNA binding protein	Homo sapiens	44-50
29383655-6	2018	Here we examined the effect of trehalose on TDP-43 clearance in a cell culture model and identified that trehalose treatment significantly reduced TDP-43 accumulation in vitro through modulation of the autophagic degradation pathway.	Trehalose	105-114	TAR DNA binding protein	Homo sapiens	147-153
29383655-7	2018	Further studies revealed that activation of TFEB induced by trehalose was responsible for the enhancement of autophagy and clearance of TDP-43 level.	Trehalose	60-69	transcription factor EB	Homo sapiens	44-48
29383655-7	2018	Further studies revealed that activation of TFEB induced by trehalose was responsible for the enhancement of autophagy and clearance of TDP-43 level.	Trehalose	60-69	TAR DNA binding protein	Homo sapiens	136-142
29383655-8	2018	These results gave us the notion that TFEB is a central regular in trehalose-mediated autophagic clearance of TDP-43 aggregates, representing an important step forward in the treatment of TDP-43 related ALS diseases.	Trehalose	67-76	transcription factor EB	Homo sapiens	38-42
29383655-8	2018	These results gave us the notion that TFEB is a central regular in trehalose-mediated autophagic clearance of TDP-43 aggregates, representing an important step forward in the treatment of TDP-43 related ALS diseases.	Trehalose	67-76	TAR DNA binding protein	Homo sapiens	110-116
29383655-8	2018	These results gave us the notion that TFEB is a central regular in trehalose-mediated autophagic clearance of TDP-43 aggregates, representing an important step forward in the treatment of TDP-43 related ALS diseases.	Trehalose	67-76	TAR DNA binding protein	Homo sapiens	188-194
29601727-0	2018	Paradoxical Effect of Trehalose on the Aggregation of alpha-Synuclein: Expedites Onset of Aggregation yet Reduces Fibril Load.	Trehalose	22-31	synuclein alpha	Homo sapiens	54-69
30013443-4	2018	We found pretreatment with trehalose not only prevented H2O2-induced death in SH-SY5Y cells, but also reversed H2O2-induced upregulation of LC3II, Beclin1 and ATG5 and downregulation of p62.	Trehalose	27-36	beclin 1	Homo sapiens	147-154
30013443-4	2018	We found pretreatment with trehalose not only prevented H2O2-induced death in SH-SY5Y cells, but also reversed H2O2-induced upregulation of LC3II, Beclin1 and ATG5 and downregulation of p62.	Trehalose	27-36	autophagy related 5	Homo sapiens	159-163
30013443-4	2018	We found pretreatment with trehalose not only prevented H2O2-induced death in SH-SY5Y cells, but also reversed H2O2-induced upregulation of LC3II, Beclin1 and ATG5 and downregulation of p62.	Trehalose	27-36	nucleoporin 62	Homo sapiens	186-189
29724354-9	2018	Trehalose administration to mice overexpressing GFP-tagged LC3 significantly increased the number of GFP-LC3 dots, both in the presence and absence of chloroquine administration.	Trehalose	0-9	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	59-62
29660529-10	2018	Together with a clear decrease in both glycogen and trehalose in the fat body, we conclude that BmSUC1 acts as an essential sucrase by directly modulating the degree of sucrose hydrolysis in the silkworm larval midgut, and insufficient sugar storage in the fat body may be responsible for larval malnutrition and abnormal petite phenotypes.	Trehalose	52-61	beta-fructofuranosidase	Bombyx mori	96-102
29724354-9	2018	Trehalose administration to mice overexpressing GFP-tagged LC3 significantly increased the number of GFP-LC3 dots, both in the presence and absence of chloroquine administration.	Trehalose	0-9	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	105-108
29700627-3	2018	METHODS: Molecular Dynamics simulations of human growth hormone (hGH) in the presence of sucrose and trehalose were performed, and the impact of phosphate and citrate buffers on their protective action was analyzed.	Trehalose	101-110	growth hormone 1	Homo sapiens	49-63
29717994-4	2018	In this study, the three-dimensional crystal structure of GAPDH treated with trehalose is reported at 2.0 A resolution.	Trehalose	77-86	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	58-63
29717994-5	2018	Trehalose was used as a cryoprotectant for the GAPDH crystals.	Trehalose	0-9	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	47-52
29717994-7	2018	At the S-loop, the bound trehalose in the GAPDH structure induces a 2.4  rotation compared with the NAD+-free ecGAPDH structure and a 3.1  rotation compared with the NAD+-bound ecGAPDH structure.	Trehalose	25-34	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-47
29665232-0	2018	Glucose-Responsive Trehalose Hydrogel for Insulin Stabilization and Delivery.	Trehalose	19-28	insulin	Homo sapiens	42-49
29665232-3	2018	Herein, a trehalose-based hydrogel is reported that stabilizes insulin to elevated temperatures prior to glucose-triggered release.	Trehalose	10-19	insulin	Homo sapiens	63-70
29665232-6	2018	Dissolution of the hydrogel is triggered upon addition of glucose as a stronger binder to boronic acid (Kb = 2.57 vs 0.48 m-1 for trehalose), allowing the insulin that is entrapped during gelation to be released in a glucose-responsive manner.	Trehalose	130-139	insulin	Homo sapiens	155-162
29665232-7	2018	Moreover, the trehalose hydrogel stabilizes the insulin as determined by immunobinding after heating up to 90  C. After 30 min heating, 74% of insulin is detected by enzyme-linked immunosorbent assay in the presence of the trehalose hydrogel, whereas only 2% is detected without any additives.	Trehalose	14-23	insulin	Homo sapiens	48-55
29665232-7	2018	Moreover, the trehalose hydrogel stabilizes the insulin as determined by immunobinding after heating up to 90  C. After 30 min heating, 74% of insulin is detected by enzyme-linked immunosorbent assay in the presence of the trehalose hydrogel, whereas only 2% is detected without any additives.	Trehalose	14-23	insulin	Homo sapiens	143-150
29665232-7	2018	Moreover, the trehalose hydrogel stabilizes the insulin as determined by immunobinding after heating up to 90  C. After 30 min heating, 74% of insulin is detected by enzyme-linked immunosorbent assay in the presence of the trehalose hydrogel, whereas only 2% is detected without any additives.	Trehalose	223-232	insulin	Homo sapiens	48-55
29665232-7	2018	Moreover, the trehalose hydrogel stabilizes the insulin as determined by immunobinding after heating up to 90  C. After 30 min heating, 74% of insulin is detected by enzyme-linked immunosorbent assay in the presence of the trehalose hydrogel, whereas only 2% is detected without any additives.	Trehalose	223-232	insulin	Homo sapiens	143-150
29241092-0	2018	Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways.	Trehalose	0-9	kelch like ECH associated protein 1	Homo sapiens	62-67
29241092-0	2018	Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways.	Trehalose	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
29241092-2	2018	Trehalose, a naturally occurring nontoxic disaccharide found in plants, insects, microorganisms and invertebrates, but not in mammals, was reported to function as a mechanistic target of the rapamycin (mTOR)-independent inducer of autophagy.	Trehalose	0-9	mechanistic target of rapamycin kinase	Homo sapiens	202-206
29241092-4	2018	In this study, we showed that trehalose not only promoted autophagy, but also increased p62 protein expression, in an autophagy-independent manner.	Trehalose	30-39	nucleoporin 62	Homo sapiens	88-91
29241092-5	2018	In addition, trehalose increased nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in a p62-dependent manner and enhance expression of its downstream antioxidant factors, heme oxygenase-1 (Ho-1) and nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 (Nqo1).	Trehalose	13-22	NFE2 like bZIP transcription factor 2	Homo sapiens	58-101
29241092-5	2018	In addition, trehalose increased nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in a p62-dependent manner and enhance expression of its downstream antioxidant factors, heme oxygenase-1 (Ho-1) and nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 (Nqo1).	Trehalose	13-22	NFE2 like bZIP transcription factor 2	Homo sapiens	103-107
29241092-5	2018	In addition, trehalose increased nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in a p62-dependent manner and enhance expression of its downstream antioxidant factors, heme oxygenase-1 (Ho-1) and nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 (Nqo1).	Trehalose	13-22	nucleoporin 62	Homo sapiens	114-117
29241092-5	2018	In addition, trehalose increased nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in a p62-dependent manner and enhance expression of its downstream antioxidant factors, heme oxygenase-1 (Ho-1) and nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 (Nqo1).	Trehalose	13-22	heme oxygenase 1	Homo sapiens	197-213
29241092-5	2018	In addition, trehalose increased nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in a p62-dependent manner and enhance expression of its downstream antioxidant factors, heme oxygenase-1 (Ho-1) and nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 (Nqo1).	Trehalose	13-22	NAD(P)H quinone dehydrogenase 1	Homo sapiens	294-298
29241092-7	2018	Collectively, these results suggested that trehalose can function as a novel activator of the p62-Keap1/Nrf2 pathway, in addition to inducing autophagy.	Trehalose	43-52	nucleoporin 62	Homo sapiens	94-97
29241092-7	2018	Collectively, these results suggested that trehalose can function as a novel activator of the p62-Keap1/Nrf2 pathway, in addition to inducing autophagy.	Trehalose	43-52	kelch like ECH associated protein 1	Homo sapiens	98-103
29241092-7	2018	Collectively, these results suggested that trehalose can function as a novel activator of the p62-Keap1/Nrf2 pathway, in addition to inducing autophagy.	Trehalose	43-52	NFE2 like bZIP transcription factor 2	Homo sapiens	104-108
29511104-8	2018	Increased trehalose is entirely dependent on a functional FOXO transcription factor DAF-16 and autophagy to promote lifespan and healthspan extension.	Trehalose	10-19	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	84-90
29425761-4	2018	These copolymers form non-covalent nanocomplexes with a model protein (lysozyme) which can be formulated into dry powders by spray-drying using common aerosol excipients (mannitol, trehalose and leucine).	Trehalose	181-190	lysozyme	Homo sapiens	71-79
29511104-9	2018	Our results reveal that when glucose is stored as glycogen, it is detrimental, whereas, when stored as trehalose, animals live a longer, healthier life if DAF-16 is functional.	Trehalose	103-112	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	155-161
29237845-5	2018	Trehalose treatment increased the levels of Rab7, a protein required for lysosomal biogenesis and fusion, and slightly decreased the levels of Rab11, which is associated with recycling endosomes.	Trehalose	0-9	RAB7B, member RAS oncogene family	Homo sapiens	44-48
29522567-7	2018	In addition, treatment with trehalose also decreased Glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP), the key proteins in the endoplasmic reticulum stress (ERS) process.	Trehalose	28-37	DNA-damage inducible transcript 3	Rattus norvegicus	94-143
29522567-7	2018	In addition, treatment with trehalose also decreased Glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP), the key proteins in the endoplasmic reticulum stress (ERS) process.	Trehalose	28-37	DNA-damage inducible transcript 3	Rattus norvegicus	145-149
29522567-8	2018	Intriguingly, we observed that trehalose promotes cryoprotected rat valve cell autophagy via an mTOR-independent but p38 MAPK-dependent signaling pathway.	Trehalose	31-40	mechanistic target of rapamycin kinase	Rattus norvegicus	96-100
29522567-7	2018	In addition, treatment with trehalose also decreased Glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP), the key proteins in the endoplasmic reticulum stress (ERS) process.	Trehalose	28-37	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	53-81
29522567-7	2018	In addition, treatment with trehalose also decreased Glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP), the key proteins in the endoplasmic reticulum stress (ERS) process.	Trehalose	28-37	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	83-88
29463761-5	2018	We showed that Hsf knockdown suppresses trehalose-induced activation of multiple predicted Hsf targets (including P. vanderplanki-specific LEA protein genes) and reduces the desiccation survival rate of Pv11 cells fivefold.	Trehalose	40-49	Heat shock factor	Drosophila melanogaster	15-18
29463761-5	2018	We showed that Hsf knockdown suppresses trehalose-induced activation of multiple predicted Hsf targets (including P. vanderplanki-specific LEA protein genes) and reduces the desiccation survival rate of Pv11 cells fivefold.	Trehalose	40-49	Heat shock factor	Drosophila melanogaster	91-94
29237845-5	2018	Trehalose treatment increased the levels of Rab7, a protein required for lysosomal biogenesis and fusion, and slightly decreased the levels of Rab11, which is associated with recycling endosomes.	Trehalose	0-9	RAB11A, member RAS oncogene family	Homo sapiens	143-148
29237845-9	2018	We propose a model in which the reciprocal effects on Rab7 and Rab11 induced by trehalose contribute to the redirection of enveloped virions from the plasma membrane to acidified compartments and subsequent degradation, and SMER28 treatment results in decreased expression levels of early and late proteins, reducing the number of virions produced without the widespread vacuolation characteristic of trehalose treatment.IMPORTANCE There is a need for less toxic HCMV antiviral drugs, and modulation of autophagy to control viral infection is a new strategy that takes advantage of virus dependence on autophagy inhibition.	Trehalose	80-89	RAB7B, member RAS oncogene family	Homo sapiens	54-58
29237845-9	2018	We propose a model in which the reciprocal effects on Rab7 and Rab11 induced by trehalose contribute to the redirection of enveloped virions from the plasma membrane to acidified compartments and subsequent degradation, and SMER28 treatment results in decreased expression levels of early and late proteins, reducing the number of virions produced without the widespread vacuolation characteristic of trehalose treatment.IMPORTANCE There is a need for less toxic HCMV antiviral drugs, and modulation of autophagy to control viral infection is a new strategy that takes advantage of virus dependence on autophagy inhibition.	Trehalose	80-89	RAB11A, member RAS oncogene family	Homo sapiens	63-68
29237845-9	2018	We propose a model in which the reciprocal effects on Rab7 and Rab11 induced by trehalose contribute to the redirection of enveloped virions from the plasma membrane to acidified compartments and subsequent degradation, and SMER28 treatment results in decreased expression levels of early and late proteins, reducing the number of virions produced without the widespread vacuolation characteristic of trehalose treatment.IMPORTANCE There is a need for less toxic HCMV antiviral drugs, and modulation of autophagy to control viral infection is a new strategy that takes advantage of virus dependence on autophagy inhibition.	Trehalose	401-410	RAB7B, member RAS oncogene family	Homo sapiens	54-58
29237845-9	2018	We propose a model in which the reciprocal effects on Rab7 and Rab11 induced by trehalose contribute to the redirection of enveloped virions from the plasma membrane to acidified compartments and subsequent degradation, and SMER28 treatment results in decreased expression levels of early and late proteins, reducing the number of virions produced without the widespread vacuolation characteristic of trehalose treatment.IMPORTANCE There is a need for less toxic HCMV antiviral drugs, and modulation of autophagy to control viral infection is a new strategy that takes advantage of virus dependence on autophagy inhibition.	Trehalose	401-410	RAB11A, member RAS oncogene family	Homo sapiens	63-68
29391797-0	2018	Dose reduction of bone morphogenetic protein-2 for bone regeneration using a delivery system based on lyophilization with trehalose.	Trehalose	122-131	bone morphogenetic protein 2	Rattus norvegicus	18-46
29278321-1	2018	This study investigated the effect of the excipients, including glycine, mannitol, arginine, trehalose, sorbitol, and poloxamer188, on the stability of recombinant human fibroblast growth factor 21(FGF21) during the process of lyophilization and storage.	Trehalose	93-102	fibroblast growth factor 21	Homo sapiens	170-197
29378963-5	2018	Despite rapid starvation, Sirt4 knockout flies paradoxically maintain elevated levels of energy reserves, including lipids, glycogen, and trehalose, while fasting, suggesting an inability to properly catabolize stored energy.	Trehalose	138-147	Sirtuin 4	Drosophila melanogaster	26-31
29391797-3	2018	Here, we investigate whether the delivery of BMP-2 lyophilized in the presence of trehalose reduced the dose of BMP-2 required for bone regeneration.	Trehalose	82-91	bone morphogenetic protein 2	Rattus norvegicus	45-50
29391797-3	2018	Here, we investigate whether the delivery of BMP-2 lyophilized in the presence of trehalose reduced the dose of BMP-2 required for bone regeneration.	Trehalose	82-91	bone morphogenetic protein 2	Rattus norvegicus	112-117
29391797-4	2018	Materials and methods: A new growth factor delivery system was fabricated using BMP-2-loaded TiO2 nanotubes by lyophilization with trehalose (TiO2-Lyo-Tre-BMP-2).	Trehalose	131-140	bone morphogenetic protein 2	Rattus norvegicus	80-85
29391797-9	2018	Conclusion: Our findings indicate that delivery of BMP-2 lyophilized with trehalose may be a promising method to reduce the dose of BMP-2 and avoid the associated side effects.	Trehalose	74-83	bone morphogenetic protein 2	Rattus norvegicus	51-56
29391797-9	2018	Conclusion: Our findings indicate that delivery of BMP-2 lyophilized with trehalose may be a promising method to reduce the dose of BMP-2 and avoid the associated side effects.	Trehalose	74-83	bone morphogenetic protein 2	Rattus norvegicus	132-137
30234068-0	2018	Downregulation of Matrix Metalloproteinases 2 and 9 is Involved in the Protective Effect of Trehalose on Spinal Cord Injury.	Trehalose	92-101	matrix metallopeptidase 2	Rattus norvegicus	18-51
29394113-7	2018	Further, we characterized the disaccharide trehalose as a novel inducer of TFEB with similar atheroprotective effects.	Trehalose	43-52	transcription factor EB	Homo sapiens	75-79
29996716-0	2018	TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose.	Trehalose	76-85	transcription factor EB	Mus musculus	0-4
29996716-4	2018	Here, we demonstrate that trehalose induces hepatocyte TFEB (transcription factor EB)-dependent thermogenesis in vivo, concomitant with upregulation of hepatic and white adipose expression of UCP1 (uncoupling protein 1 [mitochondrial, protein carrier]).	Trehalose	26-35	transcription factor EB	Mus musculus	55-59
29996716-4	2018	Here, we demonstrate that trehalose induces hepatocyte TFEB (transcription factor EB)-dependent thermogenesis in vivo, concomitant with upregulation of hepatic and white adipose expression of UCP1 (uncoupling protein 1 [mitochondrial, protein carrier]).	Trehalose	26-35	transcription factor EB	Mus musculus	61-84
29996716-4	2018	Here, we demonstrate that trehalose induces hepatocyte TFEB (transcription factor EB)-dependent thermogenesis in vivo, concomitant with upregulation of hepatic and white adipose expression of UCP1 (uncoupling protein 1 [mitochondrial, protein carrier]).	Trehalose	26-35	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	192-196
29996716-6	2018	Strikingly, hepatocyte-selective TFEB knockdown abrogated trehalose induction of thermogenesis and white adipose tissue UCP1 upregulation in vivo.	Trehalose	58-67	transcription factor EB	Mus musculus	33-37
29996716-7	2018	In contrast, we found that trehalose action on thermogenesis was independent of LEP (leptin) and the autophagy pathway, as there was robust thermogenic induction in trehalose-treated ob/ob, Becn1, Atg16l1, and Epg5 mutant mice.	Trehalose	27-36	leptin	Mus musculus	85-91
29996716-7	2018	In contrast, we found that trehalose action on thermogenesis was independent of LEP (leptin) and the autophagy pathway, as there was robust thermogenic induction in trehalose-treated ob/ob, Becn1, Atg16l1, and Epg5 mutant mice.	Trehalose	27-36	beclin 1, autophagy related	Mus musculus	190-195
29996716-7	2018	In contrast, we found that trehalose action on thermogenesis was independent of LEP (leptin) and the autophagy pathway, as there was robust thermogenic induction in trehalose-treated ob/ob, Becn1, Atg16l1, and Epg5 mutant mice.	Trehalose	27-36	autophagy related 16-like 1 (S. cerevisiae)	Mus musculus	197-204
29996716-7	2018	In contrast, we found that trehalose action on thermogenesis was independent of LEP (leptin) and the autophagy pathway, as there was robust thermogenic induction in trehalose-treated ob/ob, Becn1, Atg16l1, and Epg5 mutant mice.	Trehalose	27-36	ectopic P-granules autophagy protein 5 homolog (C. elegans)	Mus musculus	210-214
29996716-7	2018	In contrast, we found that trehalose action on thermogenesis was independent of LEP (leptin) and the autophagy pathway, as there was robust thermogenic induction in trehalose-treated ob/ob, Becn1, Atg16l1, and Epg5 mutant mice.	Trehalose	165-174	autophagy related 16-like 1 (S. cerevisiae)	Mus musculus	197-204
29996716-7	2018	In contrast, we found that trehalose action on thermogenesis was independent of LEP (leptin) and the autophagy pathway, as there was robust thermogenic induction in trehalose-treated ob/ob, Becn1, Atg16l1, and Epg5 mutant mice.	Trehalose	165-174	ectopic P-granules autophagy protein 5 homolog (C. elegans)	Mus musculus	210-214
29045036-9	2018	Mitigation of ER stress with chemical chaperone 4-PBA or trehalose suppressed significantly OGD-induced overproduction of ROS, PARP-1 upregulation, PAR polymer accumulation, and nuclear accumulation of AIF, and cell death in SH-SY5Y cells.	Trehalose	57-66	poly(ADP-ribose) polymerase 1	Homo sapiens	127-133
30234068-3	2018	Therefore, we investigated the effect of trehalose on MMP-2 and MMP-9 expression in SCI.	Trehalose	41-50	matrix metallopeptidase 2	Rattus norvegicus	54-59
30234068-3	2018	Therefore, we investigated the effect of trehalose on MMP-2 and MMP-9 expression in SCI.	Trehalose	41-50	matrix metallopeptidase 9	Rattus norvegicus	64-69
30234068-10	2018	Treatment with 10 mM trehalose significantly reduced MMP-2 expression in 3 and 7 days (P&lt; 0.01) and MMP-9 expression in 1, 3, and 7 days (P&lt; 0.05) post-damage compared with vehicle.	Trehalose	21-30	matrix metallopeptidase 2	Rattus norvegicus	53-58
30234068-10	2018	Treatment with 10 mM trehalose significantly reduced MMP-2 expression in 3 and 7 days (P&lt; 0.01) and MMP-9 expression in 1, 3, and 7 days (P&lt; 0.05) post-damage compared with vehicle.	Trehalose	21-30	matrix metallopeptidase 9	Rattus norvegicus	103-108
30234068-13	2018	We propose that the neuroprotective effect of low dose trehalose is mediated by attenuation of MMP-2 and MMP-9 expression.	Trehalose	55-64	matrix metallopeptidase 2	Rattus norvegicus	95-100
30234068-13	2018	We propose that the neuroprotective effect of low dose trehalose is mediated by attenuation of MMP-2 and MMP-9 expression.	Trehalose	55-64	matrix metallopeptidase 9	Rattus norvegicus	105-110
29175859-10	2017	In this study, the expression of tps-2 and other genes associated with trehalose metabolism, as well as lea-1, hsp-70 and gpx-1, in cold-acclimated and non-acclimated nematodes was analyzed using qPCR.	Trehalose	71-80	tryptase beta 2	Homo sapiens	33-38
29627353-5	2018	Furthermore trehalose levels increased in both w1118 and Akh1 larvae post-EPN infection, but the latter group exhibited a lower increase and total trehalose levels.	Trehalose	12-21	Adipokinetic hormone	Drosophila melanogaster	57-61
29627353-6	2018	Interestingly, baseline trehalose was relatively high in untreated AdoR1 and Akh1 AdoR1 mutants, with levels remaining unaffected by infection.	Trehalose	24-33	Adipokinetic hormone	Drosophila melanogaster	77-81
29048873-7	2017	Receptors with signaling capability interact with two distinct sets of mycobacterial glycans: targets for dectin-2 overlap with ligands for the mannose-binding endocytic receptors, while mincle binds exclusively to trehalose-containing structures such as trehalose dimycolate.	Trehalose	215-224	C-type lectin domain containing 6A	Homo sapiens	106-114
29140578-0	2018	Alleviation of cadmium-induced oxidative stress by trehalose via inhibiting the Nrf2-Keap1 signaling pathway in primary rat proximal tubular cells.	Trehalose	51-60	NFE2 like bZIP transcription factor 2	Rattus norvegicus	80-84
29140578-0	2018	Alleviation of cadmium-induced oxidative stress by trehalose via inhibiting the Nrf2-Keap1 signaling pathway in primary rat proximal tubular cells.	Trehalose	51-60	Kelch-like ECH-associated protein 1	Rattus norvegicus	85-90
29140578-2	2018	Here, we aimed to investigate whether trehalose (Tre) protects primary rat proximal tubular (rPT) cells against cadmium (Cd)-induced oxidative stress via Nrf2 antioxidant pathway.	Trehalose	38-47	NFE2 like bZIP transcription factor 2	Rattus norvegicus	154-158
29258443-5	2017	Spraying foliage of tobacco (Nicotiana tabacum) with trehalose partially alleviated symptoms of nitrogen deficiency through upregulation of nitrate and ammonia assimilation and increasing activities of nitrate reductase (NR), glycolate oxidase (GO), glutamine synthetase (GS) and glutamine oxoglutarate aminotransferase (GOGAT) with concomitant changes in ammonium (NH4+) and nitrate (NO3-) concentrations, glutamine and amino acids.	Trehalose	53-62	peroxisomal (S)-2-hydroxy-acid oxidase-like	Nicotiana tabacum	226-243
29258443-5	2017	Spraying foliage of tobacco (Nicotiana tabacum) with trehalose partially alleviated symptoms of nitrogen deficiency through upregulation of nitrate and ammonia assimilation and increasing activities of nitrate reductase (NR), glycolate oxidase (GO), glutamine synthetase (GS) and glutamine oxoglutarate aminotransferase (GOGAT) with concomitant changes in ammonium (NH4+) and nitrate (NO3-) concentrations, glutamine and amino acids.	Trehalose	53-62	peroxisomal (S)-2-hydroxy-acid oxidase-like	Nicotiana tabacum	245-247
29258443-5	2017	Spraying foliage of tobacco (Nicotiana tabacum) with trehalose partially alleviated symptoms of nitrogen deficiency through upregulation of nitrate and ammonia assimilation and increasing activities of nitrate reductase (NR), glycolate oxidase (GO), glutamine synthetase (GS) and glutamine oxoglutarate aminotransferase (GOGAT) with concomitant changes in ammonium (NH4+) and nitrate (NO3-) concentrations, glutamine and amino acids.	Trehalose	53-62	glutamine synthetase	Nicotiana tabacum	250-270
28986135-6	2017	The results showed that supplementation of semen extender with 150 mM trehalose or with 200 muM zinc sulphate significantly (P &lt; 0.05) improved motility, viability, sperm membrane integrity and acrosome status in Arabian stallion spermatozoa after cooling or after freezing and thawing compared with controls (non-supplemented media) or with those supplemented with other concentrations of trehalose or zinc sulphate.	Trehalose	393-402	latexin	Homo sapiens	92-95
28981090-8	2017	In differentiated human neuroblastoma and primary rat cortical neuron culture models, treatment with trehalose and other disaccharides resulted in accumulation of lipidated LC3 (LC3-II), p62, and autophagosomes, whereas it decreased autolysosomes.	Trehalose	101-110	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	173-176
28927620-5	2017	Storage stability testing up to 4 weeks of the model protein beta-galactosidase incorporated in pullulan/trehalose blends showed superior behavior of pure trehalose at 30 C/0% RH, while pullulan/trehalose blends yielded the best stability at 30 C/56% RH.	Trehalose	105-114	galactosidase beta 1	Homo sapiens	61-79
28927620-5	2017	Storage stability testing up to 4 weeks of the model protein beta-galactosidase incorporated in pullulan/trehalose blends showed superior behavior of pure trehalose at 30 C/0% RH, while pullulan/trehalose blends yielded the best stability at 30 C/56% RH.	Trehalose	155-164	galactosidase beta 1	Homo sapiens	61-79
28927620-5	2017	Storage stability testing up to 4 weeks of the model protein beta-galactosidase incorporated in pullulan/trehalose blends showed superior behavior of pure trehalose at 30 C/0% RH, while pullulan/trehalose blends yielded the best stability at 30 C/56% RH.	Trehalose	155-164	galactosidase beta 1	Homo sapiens	61-79
28551219-1	2017	Temperature sensitivity of bovine milk beta-lactoglobulin (BLG) was assessed in the presence/absence of non-reducing sugars (sucrose and trehalose) and polyols (glycerol and sorbitol).	Trehalose	137-146	beta-lactoglobulin	Bos taurus	39-57
27771898-4	2017	We found that pretreatment with trehalose inhibited transient global ischemia-induced neuronal death in the hippocampus CA1 neurons and OGD-induced death in SH-SY5Y cells, which was associated with inhibition of the formation of ubiquitin-labeled protein aggregates and preservation of proteasome activity.	Trehalose	32-41	carbonic anhydrase 1	Homo sapiens	120-123
29090909-2	2017	Stabilization treatments of immunoassays for matrix metalloproteinases (MMP)-8 and -9, biomarkers of periodontal disease, were conducted and compared, revealing that anti-MMP-8 and -9 capture antibodies could be stabilized with the addition of a 5% trehalose solution to the test zones, followed by drying in a vacuum oven.	Trehalose	249-258	matrix metallopeptidase 8	Homo sapiens	171-183
29063832-0	2017	daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival.	Trehalose	41-50	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	0-6
29063832-2	2017	We show that daf-16/FoxO restructures carbohydrate metabolism by driving carbon flux through the glyoxylate shunt and gluconeogenesis and into synthesis of trehalose, a disaccharide of glucose.	Trehalose	156-165	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	13-19
29063832-6	2017	This work demonstrates that daf-16/FoxO promotes starvation resistance by shifting carbon metabolism to drive trehalose synthesis, which in turn supports survival by providing an energy source and acting as a stress protectant.	Trehalose	110-119	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	28-34
28925260-4	2017	Molecular simulation experiments indicated that CoA transferase maintained its native folded state when protected by the trehalose system.	Trehalose	121-130	CoA transferase	Clostridium tyrobutyricum	48-63
28981117-3	2017	In addition, we explored the potential protective effects of trehalose, a novel Mammalian Target of Rapamycin (mTOR)-independent autophagic inducer, in TBHP-treated mouse chondrocytes and a destabilized medial meniscus (DMM) mouse OA model.	Trehalose	61-70	mechanistic target of rapamycin kinase	Homo sapiens	111-115
28981090-8	2017	In differentiated human neuroblastoma and primary rat cortical neuron culture models, treatment with trehalose and other disaccharides resulted in accumulation of lipidated LC3 (LC3-II), p62, and autophagosomes, whereas it decreased autolysosomes.	Trehalose	101-110	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	178-184
28981117-6	2017	Furthermore, trehalose restored oxidative stress-induced autophagic flux disruption and targeted autophagy selectively by activating BCL2 interacting protein 3 (BNIP3) and Phosphoglycerate mutase family member 5 (PGAM5).	Trehalose	13-22	BCL2/adenovirus E1B interacting protein 3	Mus musculus	133-159
28981117-6	2017	Furthermore, trehalose restored oxidative stress-induced autophagic flux disruption and targeted autophagy selectively by activating BCL2 interacting protein 3 (BNIP3) and Phosphoglycerate mutase family member 5 (PGAM5).	Trehalose	13-22	BCL2/adenovirus E1B interacting protein 3	Mus musculus	161-166
28981117-6	2017	Furthermore, trehalose restored oxidative stress-induced autophagic flux disruption and targeted autophagy selectively by activating BCL2 interacting protein 3 (BNIP3) and Phosphoglycerate mutase family member 5 (PGAM5).	Trehalose	13-22	phosphoglycerate mutase family member 5	Mus musculus	172-211
28981117-6	2017	Furthermore, trehalose restored oxidative stress-induced autophagic flux disruption and targeted autophagy selectively by activating BCL2 interacting protein 3 (BNIP3) and Phosphoglycerate mutase family member 5 (PGAM5).	Trehalose	13-22	phosphoglycerate mutase family member 5	Mus musculus	213-218
28981117-7	2017	Trehalose could ameliorate oxidative stress-mediated mitochondrial membrane potential collapse, ATP level decrease, dynamin-related protein 1 (drp-1) translocation into the mitochondria, and the upregulation of proteins involved in mitochondria and endoplasmic reticulum (ER) stress-related apoptosis pathway.	Trehalose	0-9	dynamin 1-like	Mus musculus	116-141
28981117-7	2017	Trehalose could ameliorate oxidative stress-mediated mitochondrial membrane potential collapse, ATP level decrease, dynamin-related protein 1 (drp-1) translocation into the mitochondria, and the upregulation of proteins involved in mitochondria and endoplasmic reticulum (ER) stress-related apoptosis pathway.	Trehalose	0-9	dynamin 1-like	Mus musculus	143-148
28981117-8	2017	In addition, trehalose suppressed the cleavage of caspase 3 and poly(ADP-ribose) polymerase (PARP) and prevented DNA damage under oxidative stress.	Trehalose	13-22	caspase 3	Mus musculus	50-59
28981117-8	2017	In addition, trehalose suppressed the cleavage of caspase 3 and poly(ADP-ribose) polymerase (PARP) and prevented DNA damage under oxidative stress.	Trehalose	13-22	poly (ADP-ribose) polymerase family, member 1	Mus musculus	64-91
28981117-8	2017	In addition, trehalose suppressed the cleavage of caspase 3 and poly(ADP-ribose) polymerase (PARP) and prevented DNA damage under oxidative stress.	Trehalose	13-22	poly (ADP-ribose) polymerase family, member 1	Mus musculus	93-97
28981117-9	2017	However, the anti-apoptotic effects of trehalose in TBHP-treated chondrocytes were partially abolished by autophagic flux inhibitor chloroquine and BNIP3- siRNA.	Trehalose	39-48	BCL2/adenovirus E1B interacting protein 3	Mus musculus	148-153
28955640-5	2017	NJ7 was generated from which we identified the gene coding for trehalose phosphate synthase (TPS1) and trehalose phosphate phosphatase (TPS2), the two enzymes most critical for trehalose production.	Trehalose	63-72	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	93-97
28955640-5	2017	NJ7 was generated from which we identified the gene coding for trehalose phosphate synthase (TPS1) and trehalose phosphate phosphatase (TPS2), the two enzymes most critical for trehalose production.	Trehalose	63-72	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	136-140
30965787-6	2017	Double-walled microspheres prepared together with excipients (PVA and trehalose) showed a better control release of lysozyme.	Trehalose	70-79	lysozyme	Homo sapiens	116-124
30965787-8	2017	Therefore, double-walled microspheres made of Glu-PLGA and PLGA together with excipients (PVA and trehalose) provide a controlled and sustained release for lysozyme.	Trehalose	98-107	lysozyme	Homo sapiens	156-164
28981090-8	2017	In differentiated human neuroblastoma and primary rat cortical neuron culture models, treatment with trehalose and other disaccharides resulted in accumulation of lipidated LC3 (LC3-II), p62, and autophagosomes, whereas it decreased autolysosomes.	Trehalose	101-110	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	187-190
28981090-10	2017	In concordance with these results, the cells treated with trehalose exhibited an incremental tendency in alpha-synuclein aggregation.	Trehalose	58-67	synuclein alpha	Homo sapiens	105-120
28981090-11	2017	Secretion of alpha-synuclein was also elevated in the culture medium upon trehalose treatment, thereby significantly increasing intercellular transmission of this protein.	Trehalose	74-83	synuclein alpha	Homo sapiens	13-28
28692243-3	2017	In contrast, trehalase (TreH), which is an enzyme required for the cleavage of trehalose, is known to be conserved and expressed.	Trehalose	79-88	trehalase	Homo sapiens	13-22
28624416-2	2017	This opportunity was used for determining how a small amount of glycerol enhances the bioprotective efficiency of trehalose during FD of lysozyme formulations.	Trehalose	114-123	lysozyme	Homo sapiens	137-145
28692243-3	2017	In contrast, trehalase (TreH), which is an enzyme required for the cleavage of trehalose, is known to be conserved and expressed.	Trehalose	79-88	trehalase	Homo sapiens	24-28
27937123-4	2017	Trehalose-6-phosphate synthase gene (tps1) and aldehyde reductase gene (ari1) were co-overexpressed in nth1 (coded for neutral trehalase gene, trehalose degrading enzyme) deleted S. cerevisiae.	Trehalose	143-152	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	37-41
27937123-4	2017	Trehalose-6-phosphate synthase gene (tps1) and aldehyde reductase gene (ari1) were co-overexpressed in nth1 (coded for neutral trehalase gene, trehalose degrading enzyme) deleted S. cerevisiae.	Trehalose	143-152	carbonyl reductase (NADPH-dependent) ARI1	Saccharomyces cerevisiae S288C	72-76
27937123-4	2017	Trehalose-6-phosphate synthase gene (tps1) and aldehyde reductase gene (ari1) were co-overexpressed in nth1 (coded for neutral trehalase gene, trehalose degrading enzyme) deleted S. cerevisiae.	Trehalose	143-152	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	103-107
28779125-7	2017	The results obtained indicated that dG9a plays an important role in maintaining energy reservoirs including amino acid, trehalose, glycogen, and triacylglycerol levels during starvation.	Trehalose	120-129	G9a	Drosophila melanogaster	36-40
28837626-9	2017	Western blot analysis, however, revealed an upregulation of synaptophysin, doublecortin and brain derived neurotrophic factor protein in trehalose treated mice in the contralateral cortex.	Trehalose	137-146	synaptophysin	Mus musculus	60-73
28837626-9	2017	Western blot analysis, however, revealed an upregulation of synaptophysin, doublecortin and brain derived neurotrophic factor protein in trehalose treated mice in the contralateral cortex.	Trehalose	137-146	doublecortin	Mus musculus	75-87
28837626-9	2017	Western blot analysis, however, revealed an upregulation of synaptophysin, doublecortin and brain derived neurotrophic factor protein in trehalose treated mice in the contralateral cortex.	Trehalose	137-146	brain derived neurotrophic factor	Mus musculus	92-125
28771200-9	2017	To test the function of the novel petunia TPS1 allele, we cloned and showed that TPS1 is a functional plant gene capable of complementing the trehalose biosynthesis pathway in a yeast tps1 mutant.	Trehalose	142-151	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	42-46
28771200-9	2017	To test the function of the novel petunia TPS1 allele, we cloned and showed that TPS1 is a functional plant gene capable of complementing the trehalose biosynthesis pathway in a yeast tps1 mutant.	Trehalose	142-151	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	81-85
28771200-9	2017	To test the function of the novel petunia TPS1 allele, we cloned and showed that TPS1 is a functional plant gene capable of complementing the trehalose biosynthesis pathway in a yeast tps1 mutant.	Trehalose	142-151	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	184-188
28500644-10	2017	Administration of trehalose, rapamycin or betanin prevented the impaired autophagic flux induced by TNBS and decreased mucosal protein levels of BCL10, p-IkappaBalpha and NFkappaB-p65 and the expression of pro-inflammatory cytokines and M1 macrophage markers.	Trehalose	18-27	B cell leukemia/lymphoma 10	Mus musculus	145-150
28786917-0	2017	Trehalose Inhibits A53T Mutant alpha-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells.	Trehalose	0-9	synuclein alpha	Rattus norvegicus	31-46
28500644-10	2017	Administration of trehalose, rapamycin or betanin prevented the impaired autophagic flux induced by TNBS and decreased mucosal protein levels of BCL10, p-IkappaBalpha and NFkappaB-p65 and the expression of pro-inflammatory cytokines and M1 macrophage markers.	Trehalose	18-27	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	154-166
28500644-10	2017	Administration of trehalose, rapamycin or betanin prevented the impaired autophagic flux induced by TNBS and decreased mucosal protein levels of BCL10, p-IkappaBalpha and NFkappaB-p65 and the expression of pro-inflammatory cytokines and M1 macrophage markers.	Trehalose	18-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	171-179
28276784-9	2017	Both sucrose and trehalose showed the lowest increase in PS and PDI of the reconstituted lyophilized NLCs.	Trehalose	17-26	peptidyl arginine deiminase 1	Homo sapiens	64-67
28632387-4	2017	The designed poly(trehalose) nanoparticles are 1000-10000 times more efficient than molecular trehalose in inhibiting protein fibrillation in extra-cellular space, in blocking aggregation of polyglutamine-containing mutant huntingtin protein in model neuronal cells, and in suppressing mutant huntingtin aggregates in HD mouse brain.	Trehalose	18-27	huntingtin	Mus musculus	223-233
28632387-4	2017	The designed poly(trehalose) nanoparticles are 1000-10000 times more efficient than molecular trehalose in inhibiting protein fibrillation in extra-cellular space, in blocking aggregation of polyglutamine-containing mutant huntingtin protein in model neuronal cells, and in suppressing mutant huntingtin aggregates in HD mouse brain.	Trehalose	18-27	huntingtin	Mus musculus	293-303
28632387-5	2017	We show that the nanoparticle form of trehalose with zwitterionic surface charge and a trehalose multivalency (i.e., number of trehalose molecules per nanoparticle) of ~80-200 are crucial for efficient brain targeting, entry into neuronal cells, and suppression of mutant huntingtin aggregation.	Trehalose	38-47	huntingtin	Mus musculus	272-282
27425791-0	2017	Trehalose induces functionally active conformation in the intrinsically disordered N-terminal domain of glucocorticoid receptor.	Trehalose	0-9	nuclear receptor subfamily 3 group C member 1	Homo sapiens	104-127
28743811-2	2017	Trehalose-6-phosphate synthase (Tps1) catalyzes the first step of trehalose biosynthesis in fungi.	Trehalose	66-75	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	32-36
28743811-13	2017	Critically, this biosynthetic pathway is absent in mammals, and thus, the two enzymes that carry out trehalose biosynthesis, namely, trehalose-6-phosphate synthase (Tps1) and trehalose-6-phosphate phosphatase (Tps2), are prominent targets for antifungal intervention.	Trehalose	101-110	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	165-169
28450107-5	2017	Activation of autophagy by Rapamycin or Trehalose could reduce the expression of Snail, demonstrating a role of autophagy in regulating Snail production both by transcriptional and post-transcriptional mechanism.	Trehalose	40-49	snail family transcriptional repressor 1	Homo sapiens	81-86
28599643-3	2017	Recently, in yeast, pH stress response genes were identified as targets of Crz1 including genes involved in glycogen and trehalose metabolism.	Trehalose	121-130	DNA-binding transcription factor CRZ1	Saccharomyces cerevisiae S288C	75-79
28589926-5	2017	In order to harness this degradative response therapeutically, we also describe a natural sugar called trehalose as an inducer of macrophage autophagy-lysosomal biogenesis and show trehalose"s ability to recapitulate the atheroprotective properties of macrophage TFEB overexpression.	Trehalose	103-112	transcription factor EB	Homo sapiens	263-267
28589926-5	2017	In order to harness this degradative response therapeutically, we also describe a natural sugar called trehalose as an inducer of macrophage autophagy-lysosomal biogenesis and show trehalose"s ability to recapitulate the atheroprotective properties of macrophage TFEB overexpression.	Trehalose	181-190	transcription factor EB	Homo sapiens	263-267
28450107-5	2017	Activation of autophagy by Rapamycin or Trehalose could reduce the expression of Snail, demonstrating a role of autophagy in regulating Snail production both by transcriptional and post-transcriptional mechanism.	Trehalose	40-49	snail family transcriptional repressor 1	Homo sapiens	136-141
28450107-6	2017	Co-immunoprecipitation (CoIP) demonstrated that LC3 co-immunoprecipitated with Smad3 and western blot showed that autophagy inducers, Rapamycin and Trehalose, could decrease the phosphorylation level of Smad3.	Trehalose	148-157	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	48-51
28450107-6	2017	Co-immunoprecipitation (CoIP) demonstrated that LC3 co-immunoprecipitated with Smad3 and western blot showed that autophagy inducers, Rapamycin and Trehalose, could decrease the phosphorylation level of Smad3.	Trehalose	148-157	SMAD family member 3	Homo sapiens	79-84
28450107-6	2017	Co-immunoprecipitation (CoIP) demonstrated that LC3 co-immunoprecipitated with Smad3 and western blot showed that autophagy inducers, Rapamycin and Trehalose, could decrease the phosphorylation level of Smad3.	Trehalose	148-157	SMAD family member 3	Homo sapiens	203-208
28180997-9	2017	The use of a putative lobster SCRT by both maltose and trehalose is nutritionally appropriate for lobsters as they commonly digest glycogen and chitin, polymers of maltose and trehalose, respectively.	Trehalose	55-64	Solute carrier family 45 member 1	Drosophila melanogaster	30-34
28552536-5	2017	In the present study, using circular dichroism- and fluorescence emission- spectroscopies, we demonstrated that in the presence of trehalose, Abeta peptide adopts more helical content and undergoes a disorder/order conformational transition.	Trehalose	131-140	amyloid beta (A4) precursor protein	Mus musculus	142-147
28552536-6	2017	Based on our findings, we conclude that trehalose affects the conformation of Abeta peptide to form alpha-helical structure, which may inhibit the formation of beta-sheets and thereby aggregation.	Trehalose	40-49	amyloid beta (A4) precursor protein	Mus musculus	78-83
28487555-2	2017	Trehalose hydrolysis enzyme, called trehalase, is highly conserved from bacteria to humans.	Trehalose	0-9	Trehalase	Drosophila melanogaster	36-45
28487555-8	2017	A reduction in adaptation ability under poor food conditions in Treh mutants is mainly caused by the overaccumulation of trehalose rather than the loss of Treh, because the additional loss of Tps1 mitigates the lethal effect of Treh mutants.	Trehalose	121-130	Trehalase	Drosophila melanogaster	64-68
28487555-8	2017	A reduction in adaptation ability under poor food conditions in Treh mutants is mainly caused by the overaccumulation of trehalose rather than the loss of Treh, because the additional loss of Tps1 mitigates the lethal effect of Treh mutants.	Trehalose	121-130	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	192-196
28180997-9	2017	The use of a putative lobster SCRT by both maltose and trehalose is nutritionally appropriate for lobsters as they commonly digest glycogen and chitin, polymers of maltose and trehalose, respectively.	Trehalose	176-185	Solute carrier family 45 member 1	Drosophila melanogaster	30-34
28068606-11	2017	These data provide essential information regarding effects of trehalose on alphaSyn accumulation and neuronal survival on exposure to PFF.	Trehalose	62-71	synuclein, alpha	Mus musculus	75-83
28276506-0	2017	Modulation of p-eIF2alpha cellular levels and stress granule assembly/disassembly by trehalose.	Trehalose	85-94	eukaryotic translation initiation factor 2A	Homo sapiens	16-25
28358370-7	2017	Moreover, incubation with autophagy inducer trehalose restored the capacity of phagocytosis, IL-6 and TNF-alpha secretion, and MHC-II expression in macrophages.	Trehalose	44-53	interleukin 6	Homo sapiens	93-97
28358370-7	2017	Moreover, incubation with autophagy inducer trehalose restored the capacity of phagocytosis, IL-6 and TNF-alpha secretion, and MHC-II expression in macrophages.	Trehalose	44-53	tumor necrosis factor	Homo sapiens	102-111
28356891-2	2017	Trehalose induces abundant autophagy in cultured cells and also reduces the rate of aggregation of the huntingtin protein in the animal model of Huntington disease, a chronic neurological disease in humans.	Trehalose	0-9	huntingtin	Homo sapiens	103-113
28192710-1	2017	In some organisms, environmental stress triggers trehalose biosynthesis that is catalyzed collectively by trehalose 6-phosphate synthase, and trehalose 6-phosphate phosphatase (T6PP).	Trehalose	49-58	trehalose-6-phosphate synthase, putative	Brugia malayi	106-136
28276506-5	2017	Mechanistically, the effect of trehalose on SGs is mediated via the p-eIF2alpha rather than autophagosome pathway.	Trehalose	31-40	eukaryotic translation initiation factor 2A	Homo sapiens	70-79
28276506-6	2017	Trehalose increases pre-stress levels of p-eIF2alpha and its phosphatase subunits and promotes post-stress translational recovery.	Trehalose	0-9	eukaryotic translation initiation factor 2A	Homo sapiens	43-52
28166771-8	2017	RESULTS: Trehalose ingestion did not evoke rapid increases in blood glucose levels, and had a lower stimulatory potency of insulin and active GIP secretion compared with glucose ingestion.	Trehalose	9-18	gastric inhibitory polypeptide	Homo sapiens	142-145
27796871-0	2017	Trehalose-6-Phosphate as a Potential Lead Candidate for the Development of Tps1 Inhibitors: Insights from the Trehalose Biosynthesis Pathway in Diverse Yeast Species.	Trehalose	0-9	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	75-79
27796871-10	2017	Based on the similarities found in sequence and function between Tps1 of S. cerevisiae and some pathogens and on the inhibitory effect of T6P on Tps1 activity observed in vitro, novel drugs can be developed for the treatment of infectious diseases caused by organisms whose infectivity and survival on the host depend on trehalose.	Trehalose	321-330	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	65-69
27796871-10	2017	Based on the similarities found in sequence and function between Tps1 of S. cerevisiae and some pathogens and on the inhibitory effect of T6P on Tps1 activity observed in vitro, novel drugs can be developed for the treatment of infectious diseases caused by organisms whose infectivity and survival on the host depend on trehalose.	Trehalose	321-330	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	145-149
28165011-4	2017	The autophagy enhancer trehalose activates TFEB by diminishing Akt activity.	Trehalose	23-32	transcription factor EB	Mus musculus	43-47
28165011-4	2017	The autophagy enhancer trehalose activates TFEB by diminishing Akt activity.	Trehalose	23-32	thymoma viral proto-oncogene 1	Mus musculus	63-66
28256519-5	2017	We observed that both trehalose and rapamycin activate autophagy in BV2 microglial cells and down-regulate the production of pro-inflammatory cytokines and nitric oxide (NO), in response to LPS and alpha-synuclein.	Trehalose	22-31	synuclein, alpha	Mus musculus	198-213
28166771-9	2017	Conversely, active GLP-1 showed higher levels from 45 to 180 min after trehalose ingestion as compared with glucose ingestion.	Trehalose	71-80	glucagon	Homo sapiens	19-24
28166771-10	2017	Specifically, active GIP secretion, which induces fat accumulation, was markedly lower after trehalose ingestion.	Trehalose	93-102	gastric inhibitory polypeptide	Homo sapiens	21-24
28079370-7	2017	These degradable polymers were then employed as excipients for the stabilization of the therapeutic protein granulocyte colony-stimulating factor (G-CSF) against storage at 4  C and shipping temperatures of 60  C. The best stabilization was observed using the trehalose- and zwitterion- substituted polyesters.	Trehalose	260-269	colony stimulating factor 3	Homo sapiens	108-145
28079370-7	2017	These degradable polymers were then employed as excipients for the stabilization of the therapeutic protein granulocyte colony-stimulating factor (G-CSF) against storage at 4  C and shipping temperatures of 60  C. The best stabilization was observed using the trehalose- and zwitterion- substituted polyesters.	Trehalose	260-269	colony stimulating factor 3	Homo sapiens	147-152
27367830-5	2017	The enzyme trehalase forms part of a pathway that converts trehalose into glucose.	Trehalose	59-68	alpha,alpha-trehalase TreA	Burkholderia pseudomallei K96243	11-20
28112221-7	2017	Transcriptome analyses revealed that trehalose dimycolate, a Mincle ligand, reduced the expression of G protein-coupled receptor kinase 2 (GRK2) in neutrophils.	Trehalose	37-46	C-type lectin domain family 4, member e	Mus musculus	61-67
28112221-7	2017	Transcriptome analyses revealed that trehalose dimycolate, a Mincle ligand, reduced the expression of G protein-coupled receptor kinase 2 (GRK2) in neutrophils.	Trehalose	37-46	G protein-coupled receptor kinase 2	Mus musculus	102-137
28112221-7	2017	Transcriptome analyses revealed that trehalose dimycolate, a Mincle ligand, reduced the expression of G protein-coupled receptor kinase 2 (GRK2) in neutrophils.	Trehalose	37-46	G protein-coupled receptor kinase 2	Mus musculus	139-143
27871371-5	2017	In addition, DM1 synthesized much higher amounts of mannose-containing disaccharide trehalose analog (Man-TA) than did the WT and DM2.	Trehalose	84-93	immunoglobulin heavy diversity 1-7	Homo sapiens	13-16
27155356-6	2017	The coupling of the NCL to density is further demonstrated by another step change at the secondary glass temperature Tg_beta in two bio-protectants, trehalose and sucrose.	Trehalose	149-158	pro-platelet basic protein	Homo sapiens	117-124
27922102-0	2016	SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.	Trehalose	30-39	solute carrier family 2 member 8	Homo sapiens	0-6
27922102-6	2016	Moreover, GLUT8-deficient hepatocytes and GLUT8-deficient mice exposed to trehalose resisted trehalose-induced AMP-activated protein kinase (AMPK) phosphorylation and autophagic induction in vitro and in vivo.	Trehalose	93-102	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	141-145
27871371-2	2017	Compared with the wild-type (WT) enzyme, the two truncated enzymes (DM1 and DM2) showed lower maltose- and trehalose-converting activities and a different transglycosylation reaction mechanism.	Trehalose	107-116	immunoglobulin heavy diversity 1-7	Homo sapiens	68-71
27871371-2	2017	Compared with the wild-type (WT) enzyme, the two truncated enzymes (DM1 and DM2) showed lower maltose- and trehalose-converting activities and a different transglycosylation reaction mechanism.	Trehalose	107-116	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	76-79
27507670-2	2017	Using a catalytically dead variant of the trehalose-6-phosphate synthase (Tps1) protein, (the first enzyme in the trehalose biosynthetic pathway), and by manipulating intracellular trehalose independently of this pathway, we demonstrated that trehalose has no role in CLS or in the inhibition of acetic acid or H202-triggered cell death.	Trehalose	42-51	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	74-78
27507670-2	2017	Using a catalytically dead variant of the trehalose-6-phosphate synthase (Tps1) protein, (the first enzyme in the trehalose biosynthetic pathway), and by manipulating intracellular trehalose independently of this pathway, we demonstrated that trehalose has no role in CLS or in the inhibition of acetic acid or H202-triggered cell death.	Trehalose	114-123	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	74-78
27507670-2	2017	Using a catalytically dead variant of the trehalose-6-phosphate synthase (Tps1) protein, (the first enzyme in the trehalose biosynthetic pathway), and by manipulating intracellular trehalose independently of this pathway, we demonstrated that trehalose has no role in CLS or in the inhibition of acetic acid or H202-triggered cell death.	Trehalose	114-123	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	74-78
27923067-6	2016	Combined removal of the glycogen and trehalose biosynthetic genes, especially GSY2 and TPS1, nearly abolishes the accumulation of storage carbohydrates and severely reduces CLS.	Trehalose	37-46	glycogen (starch) synthase GSY2	Saccharomyces cerevisiae S288C	78-82
27923067-6	2016	Combined removal of the glycogen and trehalose biosynthetic genes, especially GSY2 and TPS1, nearly abolishes the accumulation of storage carbohydrates and severely reduces CLS.	Trehalose	37-46	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	87-91
27922102-7	2016	Although trehalose profoundly attenuated mTORC1 signaling, trehalose-induced mTORC1 suppression was insufficient to activate autophagy in the absence of AMPK or GLUT8.	Trehalose	59-68	CREB regulated transcription coactivator 1	Mus musculus	77-83
27922102-9	2016	Together, these data suggest that cytoplasmic trehalose access is carrier-mediated, and that GLUT8 is a mammalian trehalose transporter required for hepatocyte trehalose-induced autophagy and signal transduction.	Trehalose	114-123	solute carrier family 2 member 8	Homo sapiens	93-98
27922102-0	2016	SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.	Trehalose	30-39	solute carrier family 2 member 8	Homo sapiens	8-13
27922102-2	2016	We recently revealed that trehalose rapidly induces hepatic autophagy and abrogates hepatic steatosis by inhibiting hexose transport via the SLC2A family of facilitative transporters.	Trehalose	26-35	solute carrier family 2 member 8	Homo sapiens	141-146
27922102-5	2016	We provide gas chromatographic/mass spectrometric, fluorescence microscopic and radiolabeled uptake evidence that trehalose traverses the plasma membrane via SLC2A8 (GLUT8), a homolog of the trehalose transporter-1 (Tret1).	Trehalose	114-123	solute carrier family 2 member 8	Homo sapiens	158-164
27922102-5	2016	We provide gas chromatographic/mass spectrometric, fluorescence microscopic and radiolabeled uptake evidence that trehalose traverses the plasma membrane via SLC2A8 (GLUT8), a homolog of the trehalose transporter-1 (Tret1).	Trehalose	114-123	solute carrier family 2 member 8	Homo sapiens	166-171
27922102-6	2016	Moreover, GLUT8-deficient hepatocytes and GLUT8-deficient mice exposed to trehalose resisted trehalose-induced AMP-activated protein kinase (AMPK) phosphorylation and autophagic induction in vitro and in vivo.	Trehalose	74-83	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	141-145
26865495-8	2016	We observed that proteins isolated from daf-2 mutants are more soluble in acidic conditions due to increased levels of trehalose.	Trehalose	119-128	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	40-45
26865495-9	2016	This suggests that trehalose may decrease the potential for protein aggregation and increases proteostasis in the daf-2 mutants.	Trehalose	19-28	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	114-119
26865495-10	2016	We postulate that daf-2 mutants save energy by decreasing protein turnover rates and instead stabilize their proteome by trehalose.	Trehalose	121-130	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	18-23
27824088-8	2016	In macrophage immune assays, beta-cell extracellular vesicles in trehalose show consistently higher TNF-alpha cytokine secretion stimulation indexes suggesting improved preservation of biological activity.	Trehalose	65-74	tumor necrosis factor	Homo sapiens	100-109
26951193-2	2016	Our previous studies on the effects of inhibiting BBX-B8 expression found that BBX-B8 is important for the development of organ, reproduction and trehalose metabolism in the silkworms.	Trehalose	146-155	bombyxin B-8	Bombyx mori	79-85
27444681-8	2016	Trehalose co-encapsulated insulin-loaded PLGA nanoparticles demonstrated enhanced hypoglycemic effect, comparatively to nanoparticles without cryoprotectant and added with trehalose, due to a superior insulin stabilization and bioactivity.	Trehalose	0-9	insulin	Homo sapiens	26-33
27444681-8	2016	Trehalose co-encapsulated insulin-loaded PLGA nanoparticles demonstrated enhanced hypoglycemic effect, comparatively to nanoparticles without cryoprotectant and added with trehalose, due to a superior insulin stabilization and bioactivity.	Trehalose	0-9	insulin	Homo sapiens	201-208
27444681-8	2016	Trehalose co-encapsulated insulin-loaded PLGA nanoparticles demonstrated enhanced hypoglycemic effect, comparatively to nanoparticles without cryoprotectant and added with trehalose, due to a superior insulin stabilization and bioactivity.	Trehalose	172-181	insulin	Homo sapiens	26-33
27510429-4	2016	Moreover, expression of the trehalose degradation-related genes NTH1 and NTH2 decreased at exponential phase in comparison with that at lag phase; compared with cells at lag phase, cells at stationary phase had higher expression of TPS1, ATH1, NTH1, and NTH2 but lower expression of TPS2.	Trehalose	28-37	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	64-68
27510429-4	2016	Moreover, expression of the trehalose degradation-related genes NTH1 and NTH2 decreased at exponential phase in comparison with that at lag phase; compared with cells at lag phase, cells at stationary phase had higher expression of TPS1, ATH1, NTH1, and NTH2 but lower expression of TPS2.	Trehalose	28-37	alpha,alpha-trehalase NTH2	Saccharomyces cerevisiae S288C	73-77
27510429-4	2016	Moreover, expression of the trehalose degradation-related genes NTH1 and NTH2 decreased at exponential phase in comparison with that at lag phase; compared with cells at lag phase, cells at stationary phase had higher expression of TPS1, ATH1, NTH1, and NTH2 but lower expression of TPS2.	Trehalose	28-37	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	232-236
27510429-4	2016	Moreover, expression of the trehalose degradation-related genes NTH1 and NTH2 decreased at exponential phase in comparison with that at lag phase; compared with cells at lag phase, cells at stationary phase had higher expression of TPS1, ATH1, NTH1, and NTH2 but lower expression of TPS2.	Trehalose	28-37	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	238-242
27510429-4	2016	Moreover, expression of the trehalose degradation-related genes NTH1 and NTH2 decreased at exponential phase in comparison with that at lag phase; compared with cells at lag phase, cells at stationary phase had higher expression of TPS1, ATH1, NTH1, and NTH2 but lower expression of TPS2.	Trehalose	28-37	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	244-248
27510429-4	2016	Moreover, expression of the trehalose degradation-related genes NTH1 and NTH2 decreased at exponential phase in comparison with that at lag phase; compared with cells at lag phase, cells at stationary phase had higher expression of TPS1, ATH1, NTH1, and NTH2 but lower expression of TPS2.	Trehalose	28-37	alpha,alpha-trehalase NTH2	Saccharomyces cerevisiae S288C	254-258
27510429-4	2016	Moreover, expression of the trehalose degradation-related genes NTH1 and NTH2 decreased at exponential phase in comparison with that at lag phase; compared with cells at lag phase, cells at stationary phase had higher expression of TPS1, ATH1, NTH1, and NTH2 but lower expression of TPS2.	Trehalose	28-37	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	283-287
27510429-5	2016	During the lag-exponential phase transition, downregulation of NTH1 and NTH2 promoted accumulation of trehalose, and to some extent, trehalose might confer ethanol tolerance to S. cerevisiae before stationary phase.	Trehalose	102-111	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	63-67
27510429-5	2016	During the lag-exponential phase transition, downregulation of NTH1 and NTH2 promoted accumulation of trehalose, and to some extent, trehalose might confer ethanol tolerance to S. cerevisiae before stationary phase.	Trehalose	102-111	alpha,alpha-trehalase NTH2	Saccharomyces cerevisiae S288C	72-76
27510429-5	2016	During the lag-exponential phase transition, downregulation of NTH1 and NTH2 promoted accumulation of trehalose, and to some extent, trehalose might confer ethanol tolerance to S. cerevisiae before stationary phase.	Trehalose	133-142	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	63-67
27510429-5	2016	During the lag-exponential phase transition, downregulation of NTH1 and NTH2 promoted accumulation of trehalose, and to some extent, trehalose might confer ethanol tolerance to S. cerevisiae before stationary phase.	Trehalose	133-142	alpha,alpha-trehalase NTH2	Saccharomyces cerevisiae S288C	72-76
27510429-6	2016	During the exponential-stationary phase transition, upregulation of TPS1 contributed to accumulation of trehalose, and Tps1 protein might be indispensable in yeast cells to withstand ethanol stress at the stationary phase.	Trehalose	104-113	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	68-72
28116420-14	2016	CONCLUSIONS: Lyophilized lenti-BMP-2 with trehalose can maintain high activity for a long time as an effective and reliable storage method.	Trehalose	42-51	bone morphogenetic protein 2	Rattus norvegicus	31-36
27595314-1	2016	Trehalose is widely used as a sweetener, humectant, and stabilizer, but is ubiquitously degraded by the enzyme trehalase expressed in a broad variety of organisms.	Trehalose	0-9	trehalase (brush-border membrane glycoprotein)	Mus musculus	111-120
27363949-9	2016	Akt2 ablation impaired glucose tolerance, myocardial geometry and function accompanied with pronounced apoptosis, ER stress and dampened autophagy, the effects of which were ameliorated by trehalose treatment.	Trehalose	189-198	thymoma viral proto-oncogene 2	Mus musculus	0-4
27363949-10	2016	Inhibition of lysosomal activity using bafilomycin A1 negated trehalose-induced induction of autophagy (LC3B-II and p62).	Trehalose	62-71	nucleoporin 62	Mus musculus	116-119
27363949-11	2016	Moreover, phosphorylation of p38 MAPK and Foxo1 were upregulated in Akt2(-/-) mice, the effect of which was attenuated by trehalose.	Trehalose	122-131	mitogen-activated protein kinase 14	Mus musculus	29-37
27363949-11	2016	Moreover, phosphorylation of p38 MAPK and Foxo1 were upregulated in Akt2(-/-) mice, the effect of which was attenuated by trehalose.	Trehalose	122-131	forkhead box O1	Mus musculus	42-47
27363949-11	2016	Moreover, phosphorylation of p38 MAPK and Foxo1 were upregulated in Akt2(-/-) mice, the effect of which was attenuated by trehalose.	Trehalose	122-131	thymoma viral proto-oncogene 2	Mus musculus	68-72
27363949-13	2016	In vitro findings revealed that the p38 MAPK activator anisomycin and the Foxo1 inhibitor (through phosphorylation) AS1842856 effectively masked trehalose-offered beneficial cardiomyocyte contractile response against Akt2 ablation.	Trehalose	145-154	mitogen-activated protein kinase 14	Mus musculus	36-44
27363949-13	2016	In vitro findings revealed that the p38 MAPK activator anisomycin and the Foxo1 inhibitor (through phosphorylation) AS1842856 effectively masked trehalose-offered beneficial cardiomyocyte contractile response against Akt2 ablation.	Trehalose	145-154	forkhead box O1	Mus musculus	74-79
27363949-13	2016	In vitro findings revealed that the p38 MAPK activator anisomycin and the Foxo1 inhibitor (through phosphorylation) AS1842856 effectively masked trehalose-offered beneficial cardiomyocyte contractile response against Akt2 ablation.	Trehalose	145-154	thymoma viral proto-oncogene 2	Mus musculus	217-221
27363949-14	2016	These data suggest that trehalose may rescue against insulin resistance-induced myocardial contractile defect and apoptosis, via autophagy associated with dephosphorylation of p38 MAPK and Foxo1 without affecting phosphorylation of Akt.	Trehalose	24-33	mitogen-activated protein kinase 14	Mus musculus	176-184
27363949-14	2016	These data suggest that trehalose may rescue against insulin resistance-induced myocardial contractile defect and apoptosis, via autophagy associated with dephosphorylation of p38 MAPK and Foxo1 without affecting phosphorylation of Akt.	Trehalose	24-33	forkhead box O1	Mus musculus	189-194
27363949-14	2016	These data suggest that trehalose may rescue against insulin resistance-induced myocardial contractile defect and apoptosis, via autophagy associated with dephosphorylation of p38 MAPK and Foxo1 without affecting phosphorylation of Akt.	Trehalose	24-33	thymoma viral proto-oncogene 1	Mus musculus	232-235
27484300-2	2016	In this study, the gene of trehalose-6-phosphate synthase (encoded by tps1), which catalyzes the first step in trehalose synthesis, was cloned and overexpressed in S. cerevisiae.	Trehalose	27-36	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	70-74
27484300-3	2016	Moreover, the gene of neutral trehalase (encoded by nth1, trehalose degrading enzyme) was deleted by using a disruption cassette, which contained long flanking homology regions of nth1 gene (the upstream 0.26 kb and downstream 0.4 kb).	Trehalose	58-67	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	52-56
27484300-8	2016	Higher intracellular trehalose accumulation by overexpression of tps1 and deletion of nth1 might provide the ability for yeast to protect against environmental stress.	Trehalose	21-30	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	65-69
27484300-8	2016	Higher intracellular trehalose accumulation by overexpression of tps1 and deletion of nth1 might provide the ability for yeast to protect against environmental stress.	Trehalose	21-30	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	86-90
27714279-2	2016	Mincle can recognize mycolic and/or corynomycolic acid esters of trehalose, glycerol and glucose from mycobacteria and corynebacteria.	Trehalose	65-74	C-type lectin domain family 4 member E	Homo sapiens	0-6
27488901-2	2016	Here, we characterize particle formation and aggregation of recombinant human interleukin-1 receptor antagonist (rhIL-1ra) in reconstituted formulations of lyophilized trehalose.	Trehalose	168-177	interleukin 1 receptor antagonist	Homo sapiens	78-111
27363949-0	2016	mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1.	Trehalose	35-44	mechanistic target of rapamycin kinase	Mus musculus	0-4
27363949-0	2016	mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1.	Trehalose	35-44	mitogen-activated protein kinase 14	Mus musculus	130-138
27363949-0	2016	mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1.	Trehalose	35-44	forkhead box O1	Mus musculus	143-148
27363949-3	2016	This study was designed to examine the effect of trehalose, an mTOR-independent autophagy inducer, on myocardial function in an Akt2 knockout-induced insulin resistance model.	Trehalose	49-58	mechanistic target of rapamycin kinase	Mus musculus	63-67
27540389-4	2016	In the present study, genome-wide characterization of putative trehalose-related genes identified 11 SlTPSs for trehalose-6-phosphate synthase, 8 SlTPPs for trehalose-6-phosphate phosphatase and one SlTRE1 for trehalase in tomato genome.	Trehalose	63-72	trehalose-6-phosphate synthase	Solanum lycopersicum	112-142
27540389-10	2016	Silencing of SlTPS3, SlTPS4, SlTPS5, SlTPS7, or SlTPP2 affected trehalose level in tomato plants with or without infection of B. cinerea or Pst DC3000.	Trehalose	64-73	(-)-camphene/tricyclene synthase, chloroplastic	Solanum lycopersicum	13-19
27540389-10	2016	Silencing of SlTPS3, SlTPS4, SlTPS5, SlTPS7, or SlTPP2 affected trehalose level in tomato plants with or without infection of B. cinerea or Pst DC3000.	Trehalose	64-73	beta-phellandrene/beta-myrcene/sabinene synthase	Solanum lycopersicum	21-27
27540389-10	2016	Silencing of SlTPS3, SlTPS4, SlTPS5, SlTPS7, or SlTPP2 affected trehalose level in tomato plants with or without infection of B. cinerea or Pst DC3000.	Trehalose	64-73	linalool synthase	Solanum lycopersicum	29-35
27540389-10	2016	Silencing of SlTPS3, SlTPS4, SlTPS5, SlTPS7, or SlTPP2 affected trehalose level in tomato plants with or without infection of B. cinerea or Pst DC3000.	Trehalose	64-73	(E)-beta-ocimene synthase	Solanum lycopersicum	37-43
27540389-11	2016	These results demonstrate that SlTPS3, SlTPS4, SlTPS5, SlTPS7, and SlTPP2 play roles in resistance against B. cinerea and Pst DC3000, implying the importance of trehalose and tis metabolism in regulation of defense response against pathogens in tomato.	Trehalose	161-170	(-)-camphene/tricyclene synthase, chloroplastic	Solanum lycopersicum	31-37
27540389-11	2016	These results demonstrate that SlTPS3, SlTPS4, SlTPS5, SlTPS7, and SlTPP2 play roles in resistance against B. cinerea and Pst DC3000, implying the importance of trehalose and tis metabolism in regulation of defense response against pathogens in tomato.	Trehalose	161-170	linalool synthase	Solanum lycopersicum	47-53
27540389-11	2016	These results demonstrate that SlTPS3, SlTPS4, SlTPS5, SlTPS7, and SlTPP2 play roles in resistance against B. cinerea and Pst DC3000, implying the importance of trehalose and tis metabolism in regulation of defense response against pathogens in tomato.	Trehalose	161-170	(E)-beta-ocimene synthase	Solanum lycopersicum	55-61
27252171-0	2016	Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo.	Trehalose	0-9	C-type lectin domain family 4, member e	Mus musculus	75-81
27420056-8	2016	Phylogenetic analysis indicated that there were four cassava TPS genes (MeTPS1-4) that were orthologous to the solely active TPS gene (AtTPS1 and OsTPS1) in Arabidopsis and rice, and a new TPP subfamily was identified in cassava, suggesting that the trehalose biosynthesis activities in cassava had potentially been enhanced in evolutionary history.	Trehalose	250-259	trehalose-6-phosphate synthase	Arabidopsis thaliana	135-141
27469628-4	2016	We here show on the basis of genetic and biochemical evidence that the trehalose synthesis enzyme Tps1 is solely responsible for the de novo synthesis of trehalose in Drosophila.	Trehalose	71-80	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	98-102
27469628-4	2016	We here show on the basis of genetic and biochemical evidence that the trehalose synthesis enzyme Tps1 is solely responsible for the de novo synthesis of trehalose in Drosophila.	Trehalose	154-163	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	98-102
27469628-5	2016	Conversely, a lack of the gene for the trehalose hydrolyzing enzyme Treh causes an accumulation of trehalose that is lethal during the pupal period, as is observed with Tps1 mutants.	Trehalose	39-48	Trehalase	Drosophila melanogaster	68-72
27469628-5	2016	Conversely, a lack of the gene for the trehalose hydrolyzing enzyme Treh causes an accumulation of trehalose that is lethal during the pupal period, as is observed with Tps1 mutants.	Trehalose	39-48	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	169-173
27469628-5	2016	Conversely, a lack of the gene for the trehalose hydrolyzing enzyme Treh causes an accumulation of trehalose that is lethal during the pupal period, as is observed with Tps1 mutants.	Trehalose	99-108	Trehalase	Drosophila melanogaster	68-72
27469628-5	2016	Conversely, a lack of the gene for the trehalose hydrolyzing enzyme Treh causes an accumulation of trehalose that is lethal during the pupal period, as is observed with Tps1 mutants.	Trehalose	99-108	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	169-173
27328819-0	2016	Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway.	Trehalose	0-9	mechanistic target of rapamycin kinase	Homo sapiens	101-105
27341800-0	2016	Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.	Trehalose	0-9	granulin precursor	Homo sapiens	22-33
27341800-8	2016	RESULTS: Here, we performed a cell-based screen of a library of known autophagy-lysosome modulators and identified multiple novel activators of a human GRN promoter reporter including several common mTOR inhibitors and an mTOR-independent activator of autophagy, trehalose.	Trehalose	263-272	granulin	Mus musculus	152-155
27341800-9	2016	Secondary cellular screens identified trehalose, a natural disaccharide, as the most promising lead compound because it increased endogenous PGRN in all cell lines tested and has multiple reported neuroprotective properties.	Trehalose	38-47	granulin precursor	Homo sapiens	141-145
27341800-10	2016	Trehalose dose-dependently increased GRN mRNA as well as intracellular and secreted PGRN in both mouse and human cell lines and this effect was independent of the transcription factor EB (TFEB).	Trehalose	0-9	granulin	Mus musculus	37-40
27341800-10	2016	Trehalose dose-dependently increased GRN mRNA as well as intracellular and secreted PGRN in both mouse and human cell lines and this effect was independent of the transcription factor EB (TFEB).	Trehalose	0-9	granulin	Mus musculus	84-88
27341800-11	2016	Moreover, trehalose rescued PGRN deficiency in human fibroblasts and neurons derived from induced pluripotent stem cells (iPSCs) generated from GRN mutation carriers.	Trehalose	10-19	granulin precursor	Homo sapiens	29-32
27341800-12	2016	Finally, oral administration of trehalose to Grn haploinsufficient mice significantly increased PGRN expression in the brain.	Trehalose	32-41	granulin	Mus musculus	45-48
27067354-5	2016	Comparative transcription and physiological analyses revealed higher long chain fatty acid, trehalose, and catalase contents might be critical factors responsible for the acetic acid resistance of JJJ1 knockout strains.	Trehalose	92-101	Jjj1p	Saccharomyces cerevisiae S288C	197-201
27236019-11	2016	Interestingly, we show that trehalose, through its capacity to induce autophagy, inhibited p62/SQSTM1 accumulation and facilitated the degradation of cytoplasmic aggregates from mHTT and alpha-synuclein proteins.	Trehalose	28-37	sequestosome 1	Mus musculus	91-94
27236019-11	2016	Interestingly, we show that trehalose, through its capacity to induce autophagy, inhibited p62/SQSTM1 accumulation and facilitated the degradation of cytoplasmic aggregates from mHTT and alpha-synuclein proteins.	Trehalose	28-37	sequestosome 1	Mus musculus	95-101
27236019-11	2016	Interestingly, we show that trehalose, through its capacity to induce autophagy, inhibited p62/SQSTM1 accumulation and facilitated the degradation of cytoplasmic aggregates from mHTT and alpha-synuclein proteins.	Trehalose	28-37	synuclein, alpha	Mus musculus	187-202
27236019-13	2016	In addition, trehalose up-regulated mature-BDNF neurotrophic factor expression and secretion, probably mediating cytoskeletal organization and helping in vesicular BDNF transport.	Trehalose	13-22	brain derived neurotrophic factor	Mus musculus	43-47
27341800-12	2016	Finally, oral administration of trehalose to Grn haploinsufficient mice significantly increased PGRN expression in the brain.	Trehalose	32-41	granulin	Mus musculus	96-100
27341800-13	2016	CONCLUSIONS: This work reports several novel autophagy-lysosome modulators that enhance PGRN expression and identifies trehalose as a promising therapeutic for raising PGRN levels to treat multiple neurodegenerative diseases.	Trehalose	119-128	granulin	Mus musculus	168-172
27328819-5	2016	Here, we found that trehalose treatment increased the LC3-I to LC3-II conversion, acridine orange-stained vacuoles and GFP-LC3B (LC3B protein tagged with green fluorescent protein) puncta in the HaCaT human keratinocyte cell line, indicating autophagy induction.	Trehalose	20-29	microtubule associated protein 1 light chain 3 beta	Homo sapiens	123-127
27328819-5	2016	Here, we found that trehalose treatment increased the LC3-I to LC3-II conversion, acridine orange-stained vacuoles and GFP-LC3B (LC3B protein tagged with green fluorescent protein) puncta in the HaCaT human keratinocyte cell line, indicating autophagy induction.	Trehalose	20-29	microtubule associated protein 1 light chain 3 beta	Homo sapiens	129-133
27328819-7	2016	mTOR signalling was not affected by trehalose treatment, suggesting that trehalose induced autophagy through an mTOR-independent pathway.	Trehalose	73-82	mechanistic target of rapamycin kinase	Homo sapiens	0-4
27328819-7	2016	mTOR signalling was not affected by trehalose treatment, suggesting that trehalose induced autophagy through an mTOR-independent pathway.	Trehalose	73-82	mechanistic target of rapamycin kinase	Homo sapiens	112-116
27080205-2	2016	Myoglobin was used as a model protein (5mg/ml with 50mg/ml trehalose in 10mM phosphate buffer, pH 6.2).	Trehalose	59-68	myoglobin	Homo sapiens	0-9
26986698-5	2016	The mRNA levels of interferon-gamma, tumour necrosis factor-like ligand 1A, interleukin-10, NADPH oxidase 4 and inducible NO synthase were significantly reduced by the trehalose supplementation.	Trehalose	168-177	interferon gamma	Homo sapiens	19-74
26986698-5	2016	The mRNA levels of interferon-gamma, tumour necrosis factor-like ligand 1A, interleukin-10, NADPH oxidase 4 and inducible NO synthase were significantly reduced by the trehalose supplementation.	Trehalose	168-177	interleukin 10	Homo sapiens	76-90
26986698-5	2016	The mRNA levels of interferon-gamma, tumour necrosis factor-like ligand 1A, interleukin-10, NADPH oxidase 4 and inducible NO synthase were significantly reduced by the trehalose supplementation.	Trehalose	168-177	NADPH oxidase 4	Homo sapiens	92-107
26986698-5	2016	The mRNA levels of interferon-gamma, tumour necrosis factor-like ligand 1A, interleukin-10, NADPH oxidase 4 and inducible NO synthase were significantly reduced by the trehalose supplementation.	Trehalose	168-177	nitric oxide synthase 2	Homo sapiens	112-133
26965428-7	2016	Moreover, mutant with simultaneous deletion of NTH1 and PUT1 exhibits the highest relative dough-leavening ability after freezing compared to mutants with single-gene deletion perhaps due to elevated levels of both trehalose and proline.	Trehalose	215-224	proline dehydrogenase	Saccharomyces cerevisiae S288C	56-60
26965428-7	2016	Moreover, mutant with simultaneous deletion of NTH1 and PUT1 exhibits the highest relative dough-leavening ability after freezing compared to mutants with single-gene deletion perhaps due to elevated levels of both trehalose and proline.	Trehalose	215-224	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	47-51
27203178-5	2016	At the G1/S transition, Cdk1 phosphorylates and activates the enzyme Nth1, which funnels the storage carbohydrate trehalose into central carbon metabolism.	Trehalose	114-123	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	24-28
27074622-5	2016	The microcapillary tip is immersed into a reservoir of negative stain or trehalose, where the sample becomes conditioned by diffusive exchange of salt and heavy metal ions or sugar molecules, respectively, before it is deposited as a small spot onto an EM grid.	Trehalose	73-82	TOR signaling pathway regulator	Homo sapiens	19-22
27027300-3	2016	In most of the fungi studied, two enzymes are involved in the synthesis of trehalose: trehalose-6-phosphate synthase (Tps1) and trehalose-6-phosphate phosphatase (Tps2).	Trehalose	75-84	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	163-167
27120679-0	2016	Trehalose-Based Glassy Matrices as an Effective Tool to Trap Short-Lived Intermediates in the Nitric Oxide Dioxygenation (NOD) Reaction of Hemoglobin.	Trehalose	0-9	TRAP	Homo sapiens	56-60
27203178-5	2016	At the G1/S transition, Cdk1 phosphorylates and activates the enzyme Nth1, which funnels the storage carbohydrate trehalose into central carbon metabolism.	Trehalose	114-123	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	69-73
25972237-4	2016	Our study highlighted the ability of an autophagy enhancer, trehalose (at concentrations of 5 and 2% in drinking water), to protect against A53T alpha-synuclein-mediated DA degeneration in an adeno-associated virus serotype 1/2 (AAV1/2)-based rat model of PD.	Trehalose	60-69	synuclein alpha	Homo sapiens	145-160
26957541-2	2016	Cell treatment with trehalose could decrease cytosolic aggregates of potentially pathogenic proteins, including mutant huntingtin, alpha-synuclein, and phosphorylated tau that are associated with neurodegenerative diseases.	Trehalose	20-29	huntingtin	Homo sapiens	119-129
26957541-2	2016	Cell treatment with trehalose could decrease cytosolic aggregates of potentially pathogenic proteins, including mutant huntingtin, alpha-synuclein, and phosphorylated tau that are associated with neurodegenerative diseases.	Trehalose	20-29	synuclein alpha	Homo sapiens	131-146
26957541-2	2016	Cell treatment with trehalose could decrease cytosolic aggregates of potentially pathogenic proteins, including mutant huntingtin, alpha-synuclein, and phosphorylated tau that are associated with neurodegenerative diseases.	Trehalose	20-29	microtubule associated protein tau	Homo sapiens	167-170
26957541-3	2016	Here, we demonstrate that trehalose also alters the metabolism of the Alzheimer disease-related amyloid precursor protein (APP).	Trehalose	26-35	amyloid beta precursor protein	Homo sapiens	96-121
26957541-7	2016	Trehalose also led to strong accumulation of the autophagic marker proteins LC3-II and p62, and decreased the proteolytic activation of the lysosomal hydrolase cathepsin D.	Trehalose	0-9	nucleoporin 62	Homo sapiens	87-90
26957541-7	2016	Trehalose also led to strong accumulation of the autophagic marker proteins LC3-II and p62, and decreased the proteolytic activation of the lysosomal hydrolase cathepsin D.	Trehalose	0-9	cathepsin D	Homo sapiens	160-171
27242146-7	2016	Our results show that Ecm27p and Ca(2+) play roles in maintaining a high level of trehalose in quiescent cells, which in turn is important in the ability of cells to rapidly return to proliferation.	Trehalose	82-91	Ecm27p	Saccharomyces cerevisiae S288C	22-28
25972237-4	2016	Our study highlighted the ability of an autophagy enhancer, trehalose (at concentrations of 5 and 2% in drinking water), to protect against A53T alpha-synuclein-mediated DA degeneration in an adeno-associated virus serotype 1/2 (AAV1/2)-based rat model of PD.	Trehalose	60-69	adeno-associated virus serotype 1/2	None	192-227
25972237-5	2016	Behavioral tests and neurochemical analysis demonstrated a significant attenuation in alpha-synuclein-mediated deficits in motor asymmetry and DA neurodegeneration including impaired DA neuronal survival and DA turnover, as well as alpha-synuclein accumulation and aggregation in the nigrostriatal system by commencing 5 and 2% trehalose at the same time as delivery of AAV.	Trehalose	328-337	synuclein alpha	Rattus norvegicus	86-101
25972237-0	2016	Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV alpha-Synuclein Rat Model of Parkinson"s Disease.	Trehalose	15-24	synuclein alpha	Rattus norvegicus	91-106
25972237-8	2016	This study supports the concept of using trehalose as a novel therapeutic strategy that might prevent/reverse alpha-synuclein aggregation for the treatment of PD.	Trehalose	41-50	synuclein alpha	Rattus norvegicus	110-125
26972381-8	2016	Fourier-transform infrared spectroscopy showed that the trehalose-containing nanoparticles presented higher insulin structural maintenance, compared to nanoparticles without cryoprotectant, presenting an insulin structural maintenance of 85.3 +- 0.7% and 86.0 +- 1.0% for annealing and no annealing, respectively.	Trehalose	56-65	insulin	Homo sapiens	108-115
26972381-8	2016	Fourier-transform infrared spectroscopy showed that the trehalose-containing nanoparticles presented higher insulin structural maintenance, compared to nanoparticles without cryoprotectant, presenting an insulin structural maintenance of 85.3 +- 0.7% and 86.0 +- 1.0% for annealing and no annealing, respectively.	Trehalose	56-65	insulin	Homo sapiens	204-211
26655178-2	2016	The BFC generates electric power from trehalose in insect hemolymph by the trehalase and glucose dehydrogenase (GDH) reaction systems which dehydrogenate beta-glucose obtained by hydrolyzing trehalose.	Trehalose	38-47	trehalase	Homo sapiens	75-84
26655178-2	2016	The BFC generates electric power from trehalose in insect hemolymph by the trehalase and glucose dehydrogenase (GDH) reaction systems which dehydrogenate beta-glucose obtained by hydrolyzing trehalose.	Trehalose	38-47	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	89-110
26655178-2	2016	The BFC generates electric power from trehalose in insect hemolymph by the trehalase and glucose dehydrogenase (GDH) reaction systems which dehydrogenate beta-glucose obtained by hydrolyzing trehalose.	Trehalose	38-47	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	112-115
26655178-2	2016	The BFC generates electric power from trehalose in insect hemolymph by the trehalase and glucose dehydrogenase (GDH) reaction systems which dehydrogenate beta-glucose obtained by hydrolyzing trehalose.	Trehalose	191-200	trehalase	Homo sapiens	75-84
26655178-2	2016	The BFC generates electric power from trehalose in insect hemolymph by the trehalase and glucose dehydrogenase (GDH) reaction systems which dehydrogenate beta-glucose obtained by hydrolyzing trehalose.	Trehalose	191-200	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	89-110
26655178-2	2016	The BFC generates electric power from trehalose in insect hemolymph by the trehalase and glucose dehydrogenase (GDH) reaction systems which dehydrogenate beta-glucose obtained by hydrolyzing trehalose.	Trehalose	191-200	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	112-115
26921190-0	2016	Trehalose-Induced Structural Transition Accelerates Aggregation of alpha-Synuclein.	Trehalose	0-9	synuclein alpha	Homo sapiens	67-82
26614086-9	2016	Depletion of trehalose by deletion of TPS2 does not affect the vital characteristics of L cells, but it improves some of these characteristics in XS cells.	Trehalose	13-22	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	38-42
26921190-3	2016	Trehalose, a non-reducing disaccharide which is conventionally used as a stabilizer, was found to order alpha-synuclein, a natively disordered protein, into a non-native conformation such that the protein folding pathway is driven towards aggregation.	Trehalose	0-9	synuclein alpha	Homo sapiens	104-119
26325072-8	2016	Trehalose-6-phosphate (T6P) and trehalose contents were evidently higher in GhTPS11 overexpressing lines 3, 5, and 22 than in WT under normal germination condition as well as chilling stress.	Trehalose	32-41	probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 11	Gossypium hirsutum	76-83
27023784-11	2016	The upregulation of autophagic flux by trehalose treatment attenuated the cardiac phenotypes such as cardiac dysfunction and structural abnormalities of mitochondria in TSC2-/- hearts.	Trehalose	39-48	TSC complex subunit 2	Mus musculus	169-173
26577464-0	2016	Downregulation of dTps1 in Drosophila melanogaster larvae confirms involvement of trehalose in redox regulation following desiccation.	Trehalose	82-91	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	18-23
26577464-6	2016	Insect trehalose synthesis is governed by the enzyme trehalose 6-phosphate synthase 1 (TPS1).	Trehalose	7-16	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	53-85
26577464-6	2016	Insect trehalose synthesis is governed by the enzyme trehalose 6-phosphate synthase 1 (TPS1).	Trehalose	7-16	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	87-91
26577464-9	2016	Furthermore, the results from molecular genetics studies, biochemical assays, electron spin resonance analyses and a simple, non-invasive method of whole larval live imaging suggested that trehalose in collaboration with superoxide dismutase (SOD) is involved in the maintenance of redox state in D. melanogaster.	Trehalose	189-198	Superoxide dismutase 1	Drosophila melanogaster	221-241
26577464-9	2016	Furthermore, the results from molecular genetics studies, biochemical assays, electron spin resonance analyses and a simple, non-invasive method of whole larval live imaging suggested that trehalose in collaboration with superoxide dismutase (SOD) is involved in the maintenance of redox state in D. melanogaster.	Trehalose	189-198	Superoxide dismutase 1	Drosophila melanogaster	243-246
26905424-3	2016	show that trehalose may also be useful in treating nonalcoholic fatty liver disease and identify inhibition of cellular glucose import through SLC2A (also known as GLUT) transporters as a mechanism by which trehalose stimulates autophagy through the adenosine monophosphate-activated protein kinase (AMPK).	Trehalose	10-19	solute carrier family 2 member 1	Homo sapiens	164-168
26905424-3	2016	show that trehalose may also be useful in treating nonalcoholic fatty liver disease and identify inhibition of cellular glucose import through SLC2A (also known as GLUT) transporters as a mechanism by which trehalose stimulates autophagy through the adenosine monophosphate-activated protein kinase (AMPK).	Trehalose	207-216	solute carrier family 2 member 1	Homo sapiens	164-168
26905426-3	2016	We showed that trehalose inhibited members of the SLC2A (also known as GLUT) family of glucose transporters.	Trehalose	15-24	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	71-75
26869786-0	2016	Enhanced osteogenic activity and anti-inflammatory properties of Lenti-BMP-2-loaded TiO2 nanotube layers fabricated by lyophilization following trehalose addition.	Trehalose	144-153	bone morphogenetic protein 2	Homo sapiens	71-76
26869786-2	2016	In this paper, Lenti-BMP-2-loaded TiO2 nanotube coatings were fabricated by lyophilization in the presence of trehalose to functionalize the surface.	Trehalose	110-119	bone morphogenetic protein 2	Homo sapiens	21-26
26869786-6	2016	Results from real-time quantitative polymerase chain reaction studies demonstrated that lyophilized Lenti-BMP-2/TiO2 nanotubes constructed with trehalose (Lyo-Tre-Lenti-BMP-2) significantly promoted osteogenic differentiation of bone marrow stromal cells but not their proliferation.	Trehalose	144-153	bone morphogenetic protein 2	Homo sapiens	106-111
26869786-6	2016	Results from real-time quantitative polymerase chain reaction studies demonstrated that lyophilized Lenti-BMP-2/TiO2 nanotubes constructed with trehalose (Lyo-Tre-Lenti-BMP-2) significantly promoted osteogenic differentiation of bone marrow stromal cells but not their proliferation.	Trehalose	144-153	bone morphogenetic protein 2	Homo sapiens	169-174
26295831-1	2016	Trehalose, a chemical chaperone and mTOR-independent autophagy enhancer, has shown promise in models of Huntington"s disease, Parkinson"s disease and tauopathies.	Trehalose	0-9	mechanistic target of rapamycin kinase	Homo sapiens	36-40
27667523-2	2016	Intracellular trehalose was elevated but the survival rate after H2O2 treatment remained low in mutants with deletion of the Catalase T gene.	Trehalose	14-23	catalase T	Saccharomyces cerevisiae S288C	125-135
26788001-3	2016	After spray-drying the modified whey protein concentrate with trehalose excipient (MWPC-TH), it was found that the alpha-lactalbumin (alpha-La) was the major protein that was further hydrolyzed the most.	Trehalose	62-71	lactalbumin alpha	Homo sapiens	115-132
26788001-3	2016	After spray-drying the modified whey protein concentrate with trehalose excipient (MWPC-TH), it was found that the alpha-lactalbumin (alpha-La) was the major protein that was further hydrolyzed the most.	Trehalose	62-71	lactalbumin alpha	Homo sapiens	134-142
26720731-6	2015	Both rapamycin and trehalose significantly reduced TAU aggregation levels suggesting that iPSC-derived neurons allow for the generation of a biologically relevant human Tauopathy model, highly suitable to screen for compounds that modulate TAU aggregation.	Trehalose	19-28	microtubule associated protein tau	Homo sapiens	51-54
28202842-2	2016	To evaluate this possibility, we examined whether trehalose suppressed the progression of insulin resistance in a placebo-controlled, double-blind trial in 34 subjects with a body mass index (BMI) &gt;=23.	Trehalose	50-59	insulin	Homo sapiens	90-97
28202842-8	2016	Our data indicated that a daily intake of 10 g of trehalose improved glucose tolerance and progress to insulin resistance.	Trehalose	50-59	insulin	Homo sapiens	103-110
27487514-6	2016	Furthermore, glucose and maltose induced the highest postprandial glucose and insulin AUC values, whereas trehalose induced the lowest postprandial glucose and insulin AUC value amongst all carbohydrate sources, respectively, in obese cats.	Trehalose	106-115	insulin	Felis catus	160-167
26474964-10	2015	The insulin in vitro release studies demonstrated that formulations with co-encapsulated trehalose, glucose, sucrose, fructose and sorbitol achieved 83%, 69%, 70%, 77% and 74%, respectively after 48h.	Trehalose	89-98	insulin	Homo sapiens	4-11
26720731-6	2015	Both rapamycin and trehalose significantly reduced TAU aggregation levels suggesting that iPSC-derived neurons allow for the generation of a biologically relevant human Tauopathy model, highly suitable to screen for compounds that modulate TAU aggregation.	Trehalose	19-28	microtubule associated protein tau	Homo sapiens	240-243
26497456-3	2016	Although Rim15p is required for the synthesis of trehalose and glycogen from UDPG upon entry of cells into the quiescent state, we found that Rim15p is also essential for the accumulation of cell wall beta-glucans, which are also anabolic products of UDPG.	Trehalose	49-58	protein kinase RIM15	Saccharomyces cerevisiae S288C	9-15
26409001-0	2015	Differential ERK activation during autophagy induced by europium hydroxide nanorods and trehalose: Maximum clearance of huntingtin aggregates through combined treatment.	Trehalose	88-97	mitogen-activated protein kinase 1	Homo sapiens	13-16
26409001-0	2015	Differential ERK activation during autophagy induced by europium hydroxide nanorods and trehalose: Maximum clearance of huntingtin aggregates through combined treatment.	Trehalose	88-97	huntingtin	Homo sapiens	120-130
26409001-5	2015	In contrast, another mTOR-independent autophagy inducer trehalose has been found to induce autophagy without activating ERK1/2 signaling pathway.	Trehalose	56-65	mechanistic target of rapamycin kinase	Homo sapiens	21-25
26409001-5	2015	In contrast, another mTOR-independent autophagy inducer trehalose has been found to induce autophagy without activating ERK1/2 signaling pathway.	Trehalose	56-65	mitogen-activated protein kinase 3	Homo sapiens	120-126
26409001-6	2015	Interestingly, the combined treatment of EHNs and trehalose leads to more degradation of mutant huntingtin protein aggregates than that obtained with single treatment of either nanorods or trehalose.	Trehalose	50-59	huntingtin	Homo sapiens	96-106
26498530-4	2015	Furthermore, the modulation of Ugp1 level readjusted glycogen and trehalose accumulation in the protein kinase A (PKA)-related gene mutants.	Trehalose	66-75	UTP glucose-1-phosphate uridylyltransferase	Saccharomyces cerevisiae S288C	31-35
26559848-0	2016	Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types.	Trehalose	0-9	mechanistic target of rapamycin kinase	Homo sapiens	14-18
26559848-6	2016	We chose to use trehalose, a nontoxic naturally occurring disaccharide that is found in plants, insects, microorganisms, and invertebrates but not in mammals and that induces autophagy by an mTOR-independent mechanism.	Trehalose	16-25	mechanistic target of rapamycin kinase	Homo sapiens	191-195
27169289-5	2015	Freeze drying with protective agent (FDP) (Trehalose) can improve the content of significantly different proteins (P &lt;= 0.001) including Collagen alpha-1 (XII) chain (COL12A1) and Collagen alpha-1 (II) chain (COL2A1).	Trehalose	43-52	collagen type XII alpha 1 chain	Homo sapiens	140-168
27169289-5	2015	Freeze drying with protective agent (FDP) (Trehalose) can improve the content of significantly different proteins (P &lt;= 0.001) including Collagen alpha-1 (XII) chain (COL12A1) and Collagen alpha-1 (II) chain (COL2A1).	Trehalose	43-52	collagen type XII alpha 1 chain	Homo sapiens	170-177
27169289-5	2015	Freeze drying with protective agent (FDP) (Trehalose) can improve the content of significantly different proteins (P &lt;= 0.001) including Collagen alpha-1 (XII) chain (COL12A1) and Collagen alpha-1 (II) chain (COL2A1).	Trehalose	43-52	collagen type II alpha 1 chain	Homo sapiens	183-210
27169289-5	2015	Freeze drying with protective agent (FDP) (Trehalose) can improve the content of significantly different proteins (P &lt;= 0.001) including Collagen alpha-1 (XII) chain (COL12A1) and Collagen alpha-1 (II) chain (COL2A1).	Trehalose	43-52	collagen type II alpha 1 chain	Homo sapiens	212-218
26498530-2	2015	In this study, we show that a considerable reduction of glycogen and trehalose content in ugp1 knockdown cells is rescued by complementing the expression of Ugp1, indicating that Ugp1 is required for the production of storage carbohydrates.	Trehalose	69-78	UTP glucose-1-phosphate uridylyltransferase	Saccharomyces cerevisiae S288C	90-94
26498530-2	2015	In this study, we show that a considerable reduction of glycogen and trehalose content in ugp1 knockdown cells is rescued by complementing the expression of Ugp1, indicating that Ugp1 is required for the production of storage carbohydrates.	Trehalose	69-78	UTP glucose-1-phosphate uridylyltransferase	Saccharomyces cerevisiae S288C	157-161
26498530-2	2015	In this study, we show that a considerable reduction of glycogen and trehalose content in ugp1 knockdown cells is rescued by complementing the expression of Ugp1, indicating that Ugp1 is required for the production of storage carbohydrates.	Trehalose	69-78	UTP glucose-1-phosphate uridylyltransferase	Saccharomyces cerevisiae S288C	179-183
26498530-3	2015	Because of the specific function of trehalose as a stress protectant, Ugp1 expression contributed to oxidative stress response and long-term cell survival during stationary phase.	Trehalose	36-45	UTP glucose-1-phosphate uridylyltransferase	Saccharomyces cerevisiae S288C	70-74
26497456-7	2016	Consistent with this, sake yeast strains with defective Rim15p exhibited impaired expression of PGM2 and UGP1 and decreased levels of beta-glucans, trehalose, and glycogen during sake fermentation.	Trehalose	148-157	protein kinase RIM15	Saccharomyces cerevisiae S288C	56-62
26598182-7	2015	10% trehalose, 1% bovine serum albumin, 3%mannitol and 0.5% gelatin in group B showed good protection on BMP-2 gene lentiviral vector.	Trehalose	4-13	bone morphogenetic protein 2	Homo sapiens	105-110
26299928-4	2015	To test the possibility that activated autophagy can degrade abnormal molecules, we investigated the effect of trehalose on abnormal aggregation of alpha-synuclein in a model of LBD.	Trehalose	111-120	synuclein, alpha	Mus musculus	148-163
26299928-6	2015	Consistent with previous studies, trehalose increased level of the autophagosomal protein LC3, especially a lipidated form LC3-II in cultured cells and mice brain.	Trehalose	34-43	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	90-93
26299928-6	2015	Consistent with previous studies, trehalose increased level of the autophagosomal protein LC3, especially a lipidated form LC3-II in cultured cells and mice brain.	Trehalose	34-43	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	123-126
26299928-7	2015	Also, trehalose increased levels of several chaperon molecules, such as HSP90 and SigmaR1, in the brains of LBD model mice.	Trehalose	6-15	heat shock protein 86, pseudogene 2	Mus musculus	72-77
26299928-7	2015	Also, trehalose increased levels of several chaperon molecules, such as HSP90 and SigmaR1, in the brains of LBD model mice.	Trehalose	6-15	sigma non-opioid intracellular receptor 1	Mus musculus	82-89
26299928-8	2015	Further studies revealed that level of detergent-insoluble alpha-synuclein was suppressed in mice following oral administration of trehalose, despite an apparent alteration was not observed regarding abnormal aggregation of alpha-synuclein.	Trehalose	131-140	synuclein, alpha	Mus musculus	59-74
25878032-5	2015	Trehalose is a major circulating carbohydrate in the fly that is recognized by the gustatory receptor Gr5a.	Trehalose	0-9	Gustatory receptor 5a	Drosophila melanogaster	102-106
25878032-6	2015	Gr5a mutant flies are short lived, and we found that they specifically increased whole-body and circulating levels of trehalose, but not other carbohydrates, likely through upregulation of de novo synthesis.	Trehalose	118-127	Gustatory receptor 5a	Drosophila melanogaster	0-4
26193345-0	2015	On-Demand Formation of Supported Lipid Membrane Arrays by Trehalose-Assisted Vesicle Delivery for SPR Imaging.	Trehalose	58-67	sepiapterin reductase	Homo sapiens	98-101
26290173-7	2015	Moreover, DAF-12, in cooperation with DAF-16/FoxO, induces negative feedback of DA synthesis via activation of the trehalose-producing enzymes TPS-1/2 and inhibition of the NADPH-producing enzyme IDH-1.	Trehalose	115-124	Nuclear hormone receptor family member daf-12	Caenorhabditis elegans	10-16
26290173-7	2015	Moreover, DAF-12, in cooperation with DAF-16/FoxO, induces negative feedback of DA synthesis via activation of the trehalose-producing enzymes TPS-1/2 and inhibition of the NADPH-producing enzyme IDH-1.	Trehalose	115-124	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	38-44
26290173-7	2015	Moreover, DAF-12, in cooperation with DAF-16/FoxO, induces negative feedback of DA synthesis via activation of the trehalose-producing enzymes TPS-1/2 and inhibition of the NADPH-producing enzyme IDH-1.	Trehalose	115-124	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1	Caenorhabditis elegans	143-150
26193345-2	2015	In this work, we demonstrate the use of trehalose vitrified phospholipid vesicles that facilitate on-demand generation of microarrays, allowing each element a unique composition, for the label-free and high-throughput analysis of biomolecular interactions by SPR imaging (SPRi).	Trehalose	40-49	sepiapterin reductase	Homo sapiens	259-262
26242687-4	2015	Circular discroism (CD) analysis of rehydrated films showed that insulin"s alpha helices and beta-sheet were well preserved for THL and SOL.	Trehalose	128-131	insulin	Homo sapiens	65-72
25757606-1	2015	However, the bioavailability of trehalose is low because it is digested by the hydrolyzing enzyme trehalase, expressed in the intestine and kidney.	Trehalose	32-41	trehalase	Homo sapiens	98-107
26062547-1	2015	In this study, an attempt has been made to understand the organization and association of fibrinogen (Fg) in solvent environment induced by viscogens such as 1-ethyl 3-methyl imidazolium ethyl sulfate (IL-emes), Ficoll, and Trehalose.	Trehalose	224-233	fibrinogen beta chain	Homo sapiens	90-100
25841320-0	2015	Trehalose decreases mutant SOD1 expression and alleviates motor deficiency in early but not end-stage amyotrophic lateral sclerosis in a SOD1-G93A mouse model.	Trehalose	0-9	superoxide dismutase 1, soluble	Mus musculus	27-31
25841320-7	2015	Trehalose significantly reduced the levels of mutant SOD1 and p62 and increased LC3-II in the spinal cords of 90-day-old SOD1-G93A transgenic mice.	Trehalose	0-9	superoxide dismutase 1, soluble	Mus musculus	53-57
25841320-7	2015	Trehalose significantly reduced the levels of mutant SOD1 and p62 and increased LC3-II in the spinal cords of 90-day-old SOD1-G93A transgenic mice.	Trehalose	0-9	nucleoporin 62	Mus musculus	62-65
25841320-7	2015	Trehalose significantly reduced the levels of mutant SOD1 and p62 and increased LC3-II in the spinal cords of 90-day-old SOD1-G93A transgenic mice.	Trehalose	0-9	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	80-83
25841320-7	2015	Trehalose significantly reduced the levels of mutant SOD1 and p62 and increased LC3-II in the spinal cords of 90-day-old SOD1-G93A transgenic mice.	Trehalose	0-9	superoxide dismutase 1, soluble	Mus musculus	121-125
25841320-8	2015	Furthermore, trehalose treatment significantly postponed disease onset, lengthened the time it took to reach a neurological score of 2 and preserved motor function; however, trehalose became less effective at delaying further disease progression as the disease progressed beyond a neurological score of 2 and it failed to extend the survival of SOD1-G93A transgenic mice.	Trehalose	13-22	superoxide dismutase 1, soluble	Mus musculus	345-349
25934390-0	2015	Yeast Tolerance to Various Stresses Relies on the Trehalose-6P Synthase (Tps1) Protein, Not on Trehalose.	Trehalose	50-59	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	73-77
25934390-2	2015	For the model yeast Saccharomyces cerevisiae, claims that trehalose is a stress protectant were based indirectly either on correlation between accumulation of trehalose and high resistance to various stresses or on stress hypersensitivity of mutants deleted for TPS1, which encodes the first enzyme in trehalose biosynthetic pathway.	Trehalose	58-67	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	262-266
26000826-1	2015	The reversible thermal denaturation of apo alpha-lactalbumin and lysozyme was monitored via measurement of changes in absorbance and ellipticity in the presence of varying concentrations of seven mono- and oligosaccharides: glucose, galactose, fructose, sucrose, trehalose, raffinose, and stachyose.	Trehalose	263-272	lysozyme	Homo sapiens	65-73
25940040-7	2015	Calculation of the Arrhenius activation energy also showed how the stabilizing efficacy of trehalose and mannitol on the catalase varies in strength across the range of drying gas inlet and outlet temperatures examined.	Trehalose	91-100	catalase	Homo sapiens	121-129
25934390-4	2015	By employing an original strategy that combined the use of mutant strains expressing catalytically inactive variants of Tps1, with MAL(+) yeast strains able to accumulate trehalose from an exogenous supply, we bring for the first time unbiased proof that trehalose does not protect yeast cells from dying and that the stress-protecting role of trehalose in this eukaryotic model was largely overestimated.	Trehalose	171-180	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	120-124
25934390-4	2015	By employing an original strategy that combined the use of mutant strains expressing catalytically inactive variants of Tps1, with MAL(+) yeast strains able to accumulate trehalose from an exogenous supply, we bring for the first time unbiased proof that trehalose does not protect yeast cells from dying and that the stress-protecting role of trehalose in this eukaryotic model was largely overestimated.	Trehalose	255-264	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	120-124
25934390-4	2015	By employing an original strategy that combined the use of mutant strains expressing catalytically inactive variants of Tps1, with MAL(+) yeast strains able to accumulate trehalose from an exogenous supply, we bring for the first time unbiased proof that trehalose does not protect yeast cells from dying and that the stress-protecting role of trehalose in this eukaryotic model was largely overestimated.	Trehalose	255-264	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	120-124
26062547-1	2015	In this study, an attempt has been made to understand the organization and association of fibrinogen (Fg) in solvent environment induced by viscogens such as 1-ethyl 3-methyl imidazolium ethyl sulfate (IL-emes), Ficoll, and Trehalose.	Trehalose	224-233	fibrinogen beta chain	Homo sapiens	102-104
26062547-6	2015	Scanning electron microscopy images show Fg in trehalose forms elongated bead like structures implying organization of the protein at the interface.	Trehalose	47-56	fibrinogen beta chain	Homo sapiens	41-43
25723473-8	2015	The SnRK1 activity was inhibited by T6P in an in vitro kinase assay, and the mRNA level of CsAGA1 in cucumber calli was up-regulated by exogenous trehalose treatment, confirming that the SnRK1 activity and CsAGA1 expression can be regulated by T6P levels.	Trehalose	146-155	probable galactinol--sucrose galactosyltransferase 1	Cucumis sativus	91-97
25818604-8	2015	The cryomedia added 15% trehalose exhibited the greatest percentage of cell viability and antioxidant enzyme activity (SOD and CAT) among frozen-thawed groups (P&lt;0.05).	Trehalose	24-33	catalase	Bos taurus	127-130
26436117-1	2015	This study shows the thermo-stability of lyophilized and purified recombinant VP7 bluetongue virus (BTV) protein in the presence of two sugar stabilizers (trehalose and mannitol) at different temperature.	Trehalose	155-164	VP7	Bluetongue virus	78-81
26436117-2	2015	Truncated VP7 protein purified by nickel affinity column was lyophilized in the presence of trehalose and mannitol at 60 mM final concentration and then exposed to different temperature like 4, 25, 37 and 45  C for various periods like 5 months, 7 weeks, 7 days and 48 h, respectively.	Trehalose	92-101	VP7	Bluetongue virus	10-13
26436117-9	2015	Trehalose could be used as stabilizer for freeze-drying the recombinant VP7 protein if an indirect ELISA kit based on the purified rVP7 protein is supplied to different laboratories of the country for detection of BTV antibody in sheep.	Trehalose	0-9	VP7	Bluetongue virus	72-75
25918382-0	2015	Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter.	Trehalose	35-44	alpha-glucoside permease	Saccharomyces cerevisiae S288C	83-87
25946077-0	2015	Effects of Trehalose on Thermodynamic Properties of Alpha-synuclein Revealed through Synchrotron Radiation Circular Dichroism.	Trehalose	11-20	synuclein alpha	Homo sapiens	52-67
25946077-3	2015	In the present work, we studied, by means of synchrotron radiation circular dichroism (SRCD) spectroscopy, the dose-effect of trehalose on alpha-synuclein conformation and/or stability to probe the capability of this osmolyte to interfere with alpha-synuclein"s aggregation.	Trehalose	126-135	synuclein alpha	Homo sapiens	139-154
25946077-4	2015	Our study indicated that a low trehalose concentration stabilized alpha-synuclein folding much better than at high concentration by blocking in vitro alpha-synuclein"s polymerisation.	Trehalose	31-40	synuclein alpha	Homo sapiens	66-81
25946077-4	2015	Our study indicated that a low trehalose concentration stabilized alpha-synuclein folding much better than at high concentration by blocking in vitro alpha-synuclein"s polymerisation.	Trehalose	31-40	synuclein alpha	Homo sapiens	150-165
25800379-2	2015	However, trehalose is digested into glucose by trehalase and which reduced its efficacy in the disease target tissues.	Trehalose	9-18	trehalase	Homo sapiens	47-56
25800379-3	2015	Therefore, searching trehalase-indigestible analogs of trehalose is a potential strategy to enhance therapeutic effect.	Trehalose	55-64	trehalase	Homo sapiens	21-30
25800379-4	2015	In this study, two trehalase-indigestible trehalose analogs, lactulose and melibiose, were selected through compound topology and functional group analyses.	Trehalose	42-51	trehalase	Homo sapiens	19-28
25800379-6	2015	Using polyQ-mediated spinocerebellar ataxia type 17 (SCA17) cell and slice cultures, we found the aggregation was significantly prohibited by trehalose, lactulose, and melibiose, which may through up-regulating of autophagy.	Trehalose	142-151	ataxin 7	Homo sapiens	21-51
25800379-6	2015	Using polyQ-mediated spinocerebellar ataxia type 17 (SCA17) cell and slice cultures, we found the aggregation was significantly prohibited by trehalose, lactulose, and melibiose, which may through up-regulating of autophagy.	Trehalose	142-151	ataxin 7	Homo sapiens	53-58
25800379-7	2015	These findings suggest the therapeutic applications of trehalase-indigestible trehalose analogs in aggregation-associated neurodegenerative diseases.	Trehalose	78-87	trehalase	Homo sapiens	55-64
25879848-6	2015	We found that trehalose-induced autophagy significantly impaired IFN-lambda1 expression and increased HRV-16 load.	Trehalose	14-23	interferon lambda 1	Homo sapiens	65-76
25879848-7	2015	Inhibition of autophagy via knockdown of autophagy-related gene 5 (ATG5) effectively rescued the impaired IFN-lambda1 expression by trehalose and subsequently reduced HRV-16 load.	Trehalose	132-141	interferon lambda 1	Homo sapiens	106-117
25884549-3	2015	Experimental support for this assumption has been obtained by expression of the carbohydrate-recognition domain of mouse mincle and characterization of its interaction with small molecule analogs of trehalose dimycolate.	Trehalose	199-208	C-type lectin domain family 4, member e	Mus musculus	121-127
25429048-3	2015	The hydrolysis of trehalose is under the enzymatic control of trehalase.	Trehalose	18-27	trehalase	Homo sapiens	62-71
25429048-4	2015	The enzyme trehalase is gaining interest in insect physiology as it regulates energy metabolism and glucose generation via trehalose catabolism.	Trehalose	123-132	trehalase	Homo sapiens	11-20
25723473-8	2015	The SnRK1 activity was inhibited by T6P in an in vitro kinase assay, and the mRNA level of CsAGA1 in cucumber calli was up-regulated by exogenous trehalose treatment, confirming that the SnRK1 activity and CsAGA1 expression can be regulated by T6P levels.	Trehalose	146-155	probable galactinol--sucrose galactosyltransferase 1	Cucumis sativus	206-212
25714733-5	2015	The developed biosensor relies on the overexpression of sugar sensitive gustatory receptors (Gr5a) in Drosophila cells to detect the salivary trehalose.	Trehalose	142-151	Gustatory receptor 5a	Drosophila melanogaster	93-97
25846877-2	2015	Trehalose contents are potentially modulated by trehalose-6-phosphate synthase (TPS), which is a key enzyme in the trehalose biosynthetic pathway.	Trehalose	0-9	alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1	Triticum aestivum	48-78
25846877-2	2015	Trehalose contents are potentially modulated by trehalose-6-phosphate synthase (TPS), which is a key enzyme in the trehalose biosynthetic pathway.	Trehalose	0-9	alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1	Triticum aestivum	80-83
25846877-2	2015	Trehalose contents are potentially modulated by trehalose-6-phosphate synthase (TPS), which is a key enzyme in the trehalose biosynthetic pathway.	Trehalose	48-57	alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1	Triticum aestivum	80-83
25434876-6	2015	It was revealed that MG132 increased the expression of A53T alpha-syn and trehalose counteracted the increase of A53T alpha-syn induced by MG132.	Trehalose	74-83	synuclein alpha	Rattus norvegicus	118-127
25617326-9	2015	Gene expression analysis showed that trehalose accumulation was, at least, partially linked to a significantly lower expression of the trehalase gene in mature galls.	Trehalose	37-46	probable trehalase	Medicago truncatula	135-144
25495218-6	2015	In the present study, we show that expression of AtTPS2 or AtTPS4 enables the yeast tps1  tps2  mutant to grow on glucose and accumulate Tre6P (trehalose 6-phosphate) and trehalose.	Trehalose	144-153	trehalose-6-phosphate synthase	Arabidopsis thaliana	49-55
25495218-6	2015	In the present study, we show that expression of AtTPS2 or AtTPS4 enables the yeast tps1  tps2  mutant to grow on glucose and accumulate Tre6P (trehalose 6-phosphate) and trehalose.	Trehalose	144-153	trehalose-6-phosphatase synthase S4	Arabidopsis thaliana	59-65
25495218-6	2015	In the present study, we show that expression of AtTPS2 or AtTPS4 enables the yeast tps1  tps2  mutant to grow on glucose and accumulate Tre6P (trehalose 6-phosphate) and trehalose.	Trehalose	144-153	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	84-88
25495218-6	2015	In the present study, we show that expression of AtTPS2 or AtTPS4 enables the yeast tps1  tps2  mutant to grow on glucose and accumulate Tre6P (trehalose 6-phosphate) and trehalose.	Trehalose	144-153	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	90-94
25462813-6	2015	We show that the refolding of recombinant CES1 was successful in Tris-HCl at pH 7.5 containing a combination of 1% glycerol and 2 mM beta-mercaptoethanol, whereas a mixture of other additives (trehalose, sorbitol and sucrose) and beta-mercaptoethanol failed to recover a functional protein.	Trehalose	193-202	carboxylesterase 1	Homo sapiens	42-46
25446361-8	2015	Autophagy inducer trehalose enhanced the nuclear translocation of transcription factor EB, accelerated the clearance of autophagosomes and alpha-synuclein and attenuated rotenone-induced cell death of PC12 cells.	Trehalose	18-27	synuclein alpha	Rattus norvegicus	139-154
25122660-0	2015	Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy.	Trehalose	53-62	androgen receptor	Homo sapiens	77-94
25451929-8	2015	Here, we demonstrate that mutants of the trehalose-synthesizing enzyme Tps1 failed to produce trehalose as expected but survived into the late pupal period and died before eclosion.	Trehalose	41-50	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	71-75
25451929-8	2015	Here, we demonstrate that mutants of the trehalose-synthesizing enzyme Tps1 failed to produce trehalose as expected but survived into the late pupal period and died before eclosion.	Trehalose	94-103	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	71-75
25451929-12	2015	These diet-dependent phenotypes of Tps1 mutants demonstrate the critical role of trehalose during development in Drosophila and reveal how animals adapt to changes in nutrient availability.	Trehalose	81-90	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	35-39
25277548-3	2015	RESULTS: In this work we show the production, purification and characterization of recombinant enzymes involved in the partitioning of glucose-1-phosphate between glycogen and trehalose in M. tuberculosis H37Rv, namely: ADP-glucose pyrophosphorylase, glycogen synthase, UDP-glucose pyrophosphorylase and trehalose-6-phosphate synthase.	Trehalose	176-185	glycogen synthase	Mycobacterium tuberculosis H37Rv	251-268
25122660-9	2015	Collectively, these data suggest that the combinatory use of Bicalutamide and trehalose is a novel approach to facilitate ARpolyQ clearance that has to be tested in other cell types target of SBMA (i.e. muscle cells) and in vivo in animal models of SBMA.	Trehalose	78-87	androgen receptor	Homo sapiens	249-253
25028392-4	2014	The results support a mechanism of binding acylated trehalose derivatives to human mincle that is very similar to the mechanism of binding to bovine mincle, in which one glucose residue in the trehalose headgroup of the glycolipid is ligated to the principle Ca(2+)-binding site in the carbohydrate-recognition domain, with specificity for the disaccharide resulting from interactions with the second glucose residue.	Trehalose	193-202	C-type lectin domain family 4 member E	Homo sapiens	83-89
25456447-7	2014	Interestingly, the protein chaperone Hsp104 compensates for loss of trehalose during short-term, but not long-term, desiccation.	Trehalose	68-77	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	37-43
25028392-4	2014	The results support a mechanism of binding acylated trehalose derivatives to human mincle that is very similar to the mechanism of binding to bovine mincle, in which one glucose residue in the trehalose headgroup of the glycolipid is ligated to the principle Ca(2+)-binding site in the carbohydrate-recognition domain, with specificity for the disaccharide resulting from interactions with the second glucose residue.	Trehalose	193-202	C-type lectin domain family 4 member E	Bos taurus	149-155
25028392-4	2014	The results support a mechanism of binding acylated trehalose derivatives to human mincle that is very similar to the mechanism of binding to bovine mincle, in which one glucose residue in the trehalose headgroup of the glycolipid is ligated to the principle Ca(2+)-binding site in the carbohydrate-recognition domain, with specificity for the disaccharide resulting from interactions with the second glucose residue.	Trehalose	52-61	C-type lectin domain family 4 member E	Homo sapiens	83-89
25028392-4	2014	The results support a mechanism of binding acylated trehalose derivatives to human mincle that is very similar to the mechanism of binding to bovine mincle, in which one glucose residue in the trehalose headgroup of the glycolipid is ligated to the principle Ca(2+)-binding site in the carbohydrate-recognition domain, with specificity for the disaccharide resulting from interactions with the second glucose residue.	Trehalose	52-61	C-type lectin domain family 4 member E	Bos taurus	149-155
25028392-7	2014	Instead, the ligand-binding conformation probably resembles closely the structure observed for bovine mincle in complex with trehalose.	Trehalose	125-134	C-type lectin domain family 4 member E	Bos taurus	102-108
24099511-4	2014	RESULTS: SLN could be freeze-dried using 10% sucrose, trehalose or maltose.	Trehalose	54-63	sarcolipin	Homo sapiens	9-12
24099511-7	2014	CONCLUSION: We confirmed that trehalose is among the most suitable cryoprotectant for SLN, however it did not improve shelf-life of the most stable formulation.	Trehalose	30-39	sarcolipin	Homo sapiens	86-89
25505447-5	2014	Transcripts of genes encoding for key members in the HBP (gfat-2, gna-2, C36A4.4) and trehalose metabolism (tre-1, tre-2, tps-2) were elevated in ogt-1 null animals.	Trehalose	86-95	Trehalase	Caenorhabditis elegans	108-113
25505447-5	2014	Transcripts of genes encoding for key members in the HBP (gfat-2, gna-2, C36A4.4) and trehalose metabolism (tre-1, tre-2, tps-2) were elevated in ogt-1 null animals.	Trehalose	86-95	Trehalase	Caenorhabditis elegans	115-120
25505447-5	2014	Transcripts of genes encoding for key members in the HBP (gfat-2, gna-2, C36A4.4) and trehalose metabolism (tre-1, tre-2, tps-2) were elevated in ogt-1 null animals.	Trehalose	86-95	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2	Caenorhabditis elegans	122-127
25505447-5	2014	Transcripts of genes encoding for key members in the HBP (gfat-2, gna-2, C36A4.4) and trehalose metabolism (tre-1, tre-2, tps-2) were elevated in ogt-1 null animals.	Trehalose	86-95	Protein O-GlcNAc transferase;UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase	Caenorhabditis elegans	146-151
25001408-5	2014	Specifically, we found that genes involved in trehalose metabolism, including a previously uncharacterized secreted trehalase (NTH2), are highly overrepresented in dormant spores.	Trehalose	46-55	trehalase (brush-border membrane glycoprotein)	Mus musculus	116-125
25268544-0	2014	Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators.	Trehalose	0-9	toll like receptor 4	Homo sapiens	81-101
25268544-0	2014	Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators.	Trehalose	0-9	toll like receptor 4	Homo sapiens	103-107
25448716-9	2014	The addition of trehalose to the suspension of liposomes stabilized LEC PLC and did not have effect on bacterial PLCs.	Trehalose	16-25	heparan sulfate proteoglycan 2	Homo sapiens	72-75
25348467-7	2014	For instance, at the water content of 1.77%, insulin without any protectants yields the highest RMSD value as 0.451 nm, then the RMSD of insulin in presence of trehalose only ca.	Trehalose	160-169	insulin	Homo sapiens	137-144
25125332-5	2014	In the present study, we found trehalose inhibited generation of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, and nitric oxide in the conditioned medium released from lipopolysaccharide (LPS)-stimulated BV-2 cells.	Trehalose	31-40	interleukin 1 beta	Mus musculus	65-82
25125332-5	2014	In the present study, we found trehalose inhibited generation of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, and nitric oxide in the conditioned medium released from lipopolysaccharide (LPS)-stimulated BV-2 cells.	Trehalose	31-40	interleukin 6	Mus musculus	84-126
25148938-0	2014	Inhibition of invasion and metastasis by DMBT, a novel trehalose derivative, through Akt/GSK-3beta/beta-catenin pathway in B16BL6 cells.	Trehalose	55-64	thymoma viral proto-oncogene 1	Mus musculus	85-88
25148938-0	2014	Inhibition of invasion and metastasis by DMBT, a novel trehalose derivative, through Akt/GSK-3beta/beta-catenin pathway in B16BL6 cells.	Trehalose	55-64	catenin (cadherin associated protein), beta 1	Mus musculus	99-111
25255859-5	2014	Imatinib or trehalose improves metabolic parameters of Atg7(+/-)-ob/ob mice and enhances autophagic flux.	Trehalose	12-21	autophagy related 7	Mus musculus	55-59
25412249-0	2014	Trehalose, an mTOR independent autophagy inducer, alleviates human podocyte injury after puromycin aminonucleoside treatment.	Trehalose	0-9	mechanistic target of rapamycin kinase	Homo sapiens	14-18
25412249-5	2014	Trehalose, a natural disaccharide, is an mTOR independent autophagy inducer.	Trehalose	0-9	mechanistic target of rapamycin kinase	Homo sapiens	41-45
25412249-12	2014	It was shown that trehalose induced podocyte autophagy in an mTOR independent manner and without reactive oxygen species involvement.	Trehalose	18-27	mechanistic target of rapamycin kinase	Homo sapiens	61-65
25268544-2	2014	We report on the synthesis and biological properties of glycolipids based on glucose and trehalose scaffolds which potently inhibit TLR4 activation and signaling in vitro and in vivo.	Trehalose	89-98	toll like receptor 4	Homo sapiens	132-136
25348467-0	2014	A molecular simulation study of the protection of insulin bioactive structure by trehalose.	Trehalose	81-90	insulin	Homo sapiens	50-57
25348467-4	2014	In the current study, insulin was chosen as an example of a thermally sensitive biopharmaceutical to investigate whether the disaccharide, trehalose, can prevent loss of structural integrity due to drying.	Trehalose	139-148	insulin	Homo sapiens	22-29
25348467-6	2014	The results indicate that trehalose preserves the bioactive structure of insulin during drying, consistent with the use of trehalose as a protectant for thermally sensitive biopharmaceuticals.	Trehalose	26-35	insulin	Homo sapiens	73-80
25348467-7	2014	For instance, at the water content of 1.77%, insulin without any protectants yields the highest RMSD value as 0.451 nm, then the RMSD of insulin in presence of trehalose only ca.	Trehalose	160-169	insulin	Homo sapiens	45-52
25202022-0	2014	C-type lectin receptor dectin-3 mediates trehalose 6,6"-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-kappaB activation.	Trehalose	41-50	C-type lectin domain family 4, member e	Mus musculus	81-87
25202022-0	2014	C-type lectin receptor dectin-3 mediates trehalose 6,6"-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-kappaB activation.	Trehalose	41-50	caspase recruitment domain family, member 9	Mus musculus	107-112
25202022-0	2014	C-type lectin receptor dectin-3 mediates trehalose 6,6"-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-kappaB activation.	Trehalose	41-50	B cell leukemia/lymphoma 10	Mus musculus	113-118
25202022-0	2014	C-type lectin receptor dectin-3 mediates trehalose 6,6"-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-kappaB activation.	Trehalose	41-50	MALT1 paracaspase	Mus musculus	119-124
25180545-2	2014	Insulin-loaded PLGA nanoparticles with a size around 450 nm were dehydrated using a standard freeze-drying cycle, using trehalose, glucose, sucrose, fructose, and sorbitol at 10% (w/v) as cryoprotectants.	Trehalose	120-129	insulin	Homo sapiens	0-7
25034910-4	2014	In old mice, supplementation with trehalose, a nutraceutical reported to enhance mitophagy, normalized mitochondrial QC markers, p66shc activation and superoxide production, and reduced aPWV and aortic collagen I (a structural protein that confers stiffness).	Trehalose	34-43	src homology 2 domain-containing transforming protein C1	Mus musculus	129-135
25034910-5	2014	In vitro experiments suggested that mitochondrial QC processes were enhanced in the aortas from old trehalose-treated mice, and in aortic rings studied ex vivo, both aging and treatment with the mitochondrial stressor rotenone were associated with increases in p66shc activation and intrinsic mechanical stiffness, whereas co-incubation with trehalose prevented these effects.	Trehalose	100-109	src homology 2 domain-containing transforming protein C1	Mus musculus	261-267
25034910-5	2014	In vitro experiments suggested that mitochondrial QC processes were enhanced in the aortas from old trehalose-treated mice, and in aortic rings studied ex vivo, both aging and treatment with the mitochondrial stressor rotenone were associated with increases in p66shc activation and intrinsic mechanical stiffness, whereas co-incubation with trehalose prevented these effects.	Trehalose	342-351	src homology 2 domain-containing transforming protein C1	Mus musculus	261-267
25259530-8	2014	Trehalose application also increased CHIP and HSP70 expression and GSH free radical levels.	Trehalose	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	46-51
25259530-9	2014	Furthermore, trehalose augmented macro and chaperone mediated autophagy (CMA), rising the levels of LC3, LAMP2, CD63 and increasing the expression of Beclin-1 and Atg5-Atg12.	Trehalose	13-22	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	100-103
25259530-9	2014	Furthermore, trehalose augmented macro and chaperone mediated autophagy (CMA), rising the levels of LC3, LAMP2, CD63 and increasing the expression of Beclin-1 and Atg5-Atg12.	Trehalose	13-22	lysosomal associated membrane protein 2	Homo sapiens	105-110
25259530-9	2014	Furthermore, trehalose augmented macro and chaperone mediated autophagy (CMA), rising the levels of LC3, LAMP2, CD63 and increasing the expression of Beclin-1 and Atg5-Atg12.	Trehalose	13-22	CD63 molecule	Homo sapiens	112-116
25259530-9	2014	Furthermore, trehalose augmented macro and chaperone mediated autophagy (CMA), rising the levels of LC3, LAMP2, CD63 and increasing the expression of Beclin-1 and Atg5-Atg12.	Trehalose	13-22	beclin 1	Homo sapiens	150-158
25259530-9	2014	Furthermore, trehalose augmented macro and chaperone mediated autophagy (CMA), rising the levels of LC3, LAMP2, CD63 and increasing the expression of Beclin-1 and Atg5-Atg12.	Trehalose	13-22	autophagy related 5	Homo sapiens	163-167
25259530-9	2014	Furthermore, trehalose augmented macro and chaperone mediated autophagy (CMA), rising the levels of LC3, LAMP2, CD63 and increasing the expression of Beclin-1 and Atg5-Atg12.	Trehalose	13-22	autophagy related 12	Homo sapiens	168-173
25259530-10	2014	Trehalose treatment in addition increased the percentage of immunoreactive cells to HSC70 and LAMP2 and reduced the autophagic substrate, p62.	Trehalose	0-9	heat shock protein family A (Hsp70) member 8	Homo sapiens	84-89
25259530-10	2014	Trehalose treatment in addition increased the percentage of immunoreactive cells to HSC70 and LAMP2 and reduced the autophagic substrate, p62.	Trehalose	0-9	lysosomal associated membrane protein 2	Homo sapiens	94-99
25259530-10	2014	Trehalose treatment in addition increased the percentage of immunoreactive cells to HSC70 and LAMP2 and reduced the autophagic substrate, p62.	Trehalose	0-9	nucleoporin 62	Homo sapiens	138-141
24800789-4	2014	RESULTS: Trehalose-6-phosphate phosphatase (TPP) catalyzes the final step of trehalose metabolism.	Trehalose	77-86	trehalose-6-phosphate phosphatase	Arabidopsis thaliana	9-42
24800789-4	2014	RESULTS: Trehalose-6-phosphate phosphatase (TPP) catalyzes the final step of trehalose metabolism.	Trehalose	77-86	trehalose-6-phosphate phosphatase	Arabidopsis thaliana	44-47
25001408-5	2014	Specifically, we found that genes involved in trehalose metabolism, including a previously uncharacterized secreted trehalase (NTH2), are highly overrepresented in dormant spores.	Trehalose	46-55	nuclear encoded tRNA histidine 2 (anticodon GTG)	Mus musculus	127-131
24935007-2	2014	The promotion of trehalose for MEC efficiency was obvious and the optimal concentration of trehalose was 50 mmol/L.	Trehalose	17-26	C-C motif chemokine ligand 28	Homo sapiens	31-34
25064079-7	2014	MPTP-induced losses in tyrosine hydroxylase and DA transporter immunoreactivity in the ventral midbrain SNc and CPu were significantly reduced by trehalose.	Trehalose	146-155	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	48-62
25064079-11	2014	Two tight junctional proteins, ZO-1 and occludin, are downregulated following MPTP treatment and trehalose blocks this effect.	Trehalose	97-106	tight junction protein 1	Mus musculus	31-48
24935007-2	2014	The promotion of trehalose for MEC efficiency was obvious and the optimal concentration of trehalose was 50 mmol/L.	Trehalose	91-100	C-C motif chemokine ligand 28	Homo sapiens	31-34
24768772-4	2014	Furthermore, the effect of a well known bioprotectant, trehalose, that influences alpha-synuclein fibrillation, on both soluble and fibrillar forms of alpha-synuclein is discussed.	Trehalose	55-64	synuclein alpha	Homo sapiens	82-97
24951963-2	2014	In this study, strain TL301(TPS1) overexpressing TPS1 showed 62.92 % higher trehalose-6-phosphate synthase (Tps1) activity and enhanced the content of intracellular trehalose than the parental strain.	Trehalose	76-85	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	28-32
24951963-2	2014	In this study, strain TL301(TPS1) overexpressing TPS1 showed 62.92 % higher trehalose-6-phosphate synthase (Tps1) activity and enhanced the content of intracellular trehalose than the parental strain.	Trehalose	76-85	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	49-53
24951963-3	2014	Deleting ATH1 exerted a significant effect on trehalase activities and the degradation amount of intracellular trehalose during the first 30 min of prefermentation.	Trehalose	111-120	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	9-13
24951963-4	2014	This finding indicates that acid trehalase (Ath1) plays a role in intracellular trehalose degradation.	Trehalose	80-89	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	44-48
24951963-5	2014	NTH2 encodes a functional neutral trehalase (Nth2) that was significantly involved in intracellular trehalose degradation in the absence of the NTH1 and/or ATH1 gene.	Trehalose	100-109	alpha,alpha-trehalase NTH2	Saccharomyces cerevisiae S288C	0-4
24951963-5	2014	NTH2 encodes a functional neutral trehalase (Nth2) that was significantly involved in intracellular trehalose degradation in the absence of the NTH1 and/or ATH1 gene.	Trehalose	100-109	alpha,alpha-trehalase NTH2	Saccharomyces cerevisiae S288C	45-49
24951963-7	2014	The increase in freeze tolerance of strain TL301(TPS1) was accompanied by relatively low trehalase activity, high Tps1 activity and high residual content of intracellular trehalose.	Trehalose	171-180	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	49-53
25003205-1	2014	As one of the major hydrolases in Drosophila, trehalase (Treh) catalyzes the hydrolysis of trehalose into glucose providing energy for flight muscle activity.	Trehalose	91-100	Trehalase	Drosophila melanogaster	46-55
25003205-1	2014	As one of the major hydrolases in Drosophila, trehalase (Treh) catalyzes the hydrolysis of trehalose into glucose providing energy for flight muscle activity.	Trehalose	91-100	Trehalase	Drosophila melanogaster	57-61
24999534-14	2014	As expected from the analysis of the Amide I band, the maximum effect of glycerol on trehalose is determined for 5% Glyc/TRE content.	Trehalose	85-94	tRNA-Glu (anticodon TTC) 3-1	Homo sapiens	121-124
24768772-4	2014	Furthermore, the effect of a well known bioprotectant, trehalose, that influences alpha-synuclein fibrillation, on both soluble and fibrillar forms of alpha-synuclein is discussed.	Trehalose	55-64	synuclein alpha	Homo sapiens	151-166
24248470-7	2014	Additionally, trehalose led to the overexpression of the heat shock protein, Hsp104p, in mutant huntingtin-expressing cells, and resulted in rescue of the endocytotic defect in the yeast cell.	Trehalose	14-23	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	77-84
24923784-9	2014	In assays of carbohydrate levels we found that 5-HT1A knockdown in IPCs resulted in elevated hemolymph glucose, body glycogen and body trehalose levels, while no effects were seen after OAMB knockdown.	Trehalose	135-144	5-hydroxytryptamine (serotonin) receptor 1A	Drosophila melanogaster	47-53
24380875-4	2014	RESULTS: Tsl1 deficiency totally abolished the increase in Tps1 activity and accumulation of trehalose in response to a heat stress, whereas absence of Tps3 only reduced Tps1 activity and trehalose synthesis.	Trehalose	93-102	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	9-13
24380875-4	2014	RESULTS: Tsl1 deficiency totally abolished the increase in Tps1 activity and accumulation of trehalose in response to a heat stress, whereas absence of Tps3 only reduced Tps1 activity and trehalose synthesis.	Trehalose	188-197	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	152-156
24380875-9	2014	CONCLUSION: Taken together these results suggest that Tsl1 is a decisive subunit for activity of the TPS complex since in its absence no trehalose synthesis occurred.	Trehalose	137-146	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	54-58
24380875-12	2014	To readily stop trehalose synthesis during stress recovery, Tps3 must be phosphorylated by cAMP-dependent protein kinase, decreasing Tps2 activity and, consequently, increasing the concentration of T6P which would inhibit Tps1.	Trehalose	16-25	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	60-64
24380875-12	2014	To readily stop trehalose synthesis during stress recovery, Tps3 must be phosphorylated by cAMP-dependent protein kinase, decreasing Tps2 activity and, consequently, increasing the concentration of T6P which would inhibit Tps1.	Trehalose	16-25	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	133-137
24380875-12	2014	To readily stop trehalose synthesis during stress recovery, Tps3 must be phosphorylated by cAMP-dependent protein kinase, decreasing Tps2 activity and, consequently, increasing the concentration of T6P which would inhibit Tps1.	Trehalose	16-25	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	222-226
25352718-7	2014	Administration of trehalose, an inducer of TFEB, mitigated RC4 cell death caused by TNFalpha/CHX.	Trehalose	18-27	transcription factor EB	Homo sapiens	43-47
25352718-7	2014	Administration of trehalose, an inducer of TFEB, mitigated RC4 cell death caused by TNFalpha/CHX.	Trehalose	18-27	tumor necrosis factor	Homo sapiens	84-92
24929414-0	2014	Relationship between beta-relaxation and structural stability of lysozyme: microscopic insight on thermostabilization mechanism by trehalose from Raman spectroscopy experiments.	Trehalose	131-140	lysozyme	Homo sapiens	65-73
24929414-4	2014	The use of heavy water and partly deuterated trehalose gives clear information on protein-trehalose interactions in the native state of lysozyme (at room temperature) and during the thermal denaturation process of lysozyme.	Trehalose	45-54	lysozyme	Homo sapiens	136-144
24929414-4	2014	The use of heavy water and partly deuterated trehalose gives clear information on protein-trehalose interactions in the native state of lysozyme (at room temperature) and during the thermal denaturation process of lysozyme.	Trehalose	45-54	lysozyme	Homo sapiens	214-222
24929414-4	2014	The use of heavy water and partly deuterated trehalose gives clear information on protein-trehalose interactions in the native state of lysozyme (at room temperature) and during the thermal denaturation process of lysozyme.	Trehalose	90-99	lysozyme	Homo sapiens	136-144
24929414-4	2014	The use of heavy water and partly deuterated trehalose gives clear information on protein-trehalose interactions in the native state of lysozyme (at room temperature) and during the thermal denaturation process of lysozyme.	Trehalose	90-99	lysozyme	Homo sapiens	214-222
24929414-7	2014	Upon heating, interaction between trehalose and lysozyme is detected during the solvent penetration within the protein, i.e., while the native globular state softens into a molten globule (MG) state.	Trehalose	34-43	lysozyme	Homo sapiens	48-56
24568549-8	2014	Notably, trehalose is an mTOR-independent inducer of autophagy, and in animal models of neurodegenerative disorders including Alzheimer"s disease, Parkinson"s disease, and Huntington"s disease, has been shown to decrease the levels of toxic protein aggregates, increase autophagy, and improve clinical symptoms and survival.	Trehalose	9-18	mechanistic target of rapamycin kinase	Homo sapiens	25-29
24583208-3	2014	The OVA-41 was successfully freeze-dried using the excipients 5% trehalose and 1% PEG8000.	Trehalose	65-74	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	4-7
24803712-5	2014	Differential scanning calorimetry (DSC) revealed a shift in peak thermal transition temperature (T p) of myosin and actin to higher temperature as the mass fraction of trehalose increases.	Trehalose	168-177	myosin, heavy chain 15	Gallus gallus	105-111
24803712-6	2014	The transitions enthalpies of myosin and actin of WCM samples showed higher increase with the increase of mass fraction of trehalose.	Trehalose	123-132	myosin, heavy chain 15	Gallus gallus	30-36
24441414-0	2014	MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.	Trehalose	38-47	mechanistic target of rapamycin kinase	Mus musculus	0-4
24782885-9	2014	One such specific pathway where modification of trehalose metabolism improved stress tolerance, without any side effects, was recently obtained by overexpression of trehalase, which results in a more sensitive reaction of the stomatal guard cells and closing of the stomata under drought stress conditions.	Trehalose	48-57	trehalase	Homo sapiens	165-174
24412307-6	2014	Using mutants of an isogenic strain which do not express the major trehalose synthetic or metabolising enzymes or the chaperone, heat shock protein 104 (Hsp104), we were able to identify the functions of Hsp104 and the osmoprotectant trehalose in solubilising mutant huntingtin.	Trehalose	234-243	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	204-210
24441414-6	2014	We have found that trehalose significantly delays disease onset prolongs life span, and reduces motor neuron loss in the spinal cord of SOD1(G93A) mice.	Trehalose	19-28	superoxide dismutase 1, soluble	Mus musculus	136-140
24441414-7	2014	Most importantly, we have documented that trehalose decreases SOD1 and SQSTM1/p62 aggregation, reduces ubiquitinated protein accumulation, and improves autophagic flux in the motor neurons of SOD1(G93A) mice.	Trehalose	42-51	superoxide dismutase 1, soluble	Mus musculus	62-66
24441414-7	2014	Most importantly, we have documented that trehalose decreases SOD1 and SQSTM1/p62 aggregation, reduces ubiquitinated protein accumulation, and improves autophagic flux in the motor neurons of SOD1(G93A) mice.	Trehalose	42-51	sequestosome 1	Mus musculus	71-77
24441414-7	2014	Most importantly, we have documented that trehalose decreases SOD1 and SQSTM1/p62 aggregation, reduces ubiquitinated protein accumulation, and improves autophagic flux in the motor neurons of SOD1(G93A) mice.	Trehalose	42-51	sequestosome 1	Mus musculus	78-81
24441414-7	2014	Most importantly, we have documented that trehalose decreases SOD1 and SQSTM1/p62 aggregation, reduces ubiquitinated protein accumulation, and improves autophagic flux in the motor neurons of SOD1(G93A) mice.	Trehalose	42-51	superoxide dismutase 1, soluble	Mus musculus	192-196
24441414-8	2014	Moreover, we have demonstrated that trehalose can reduce skeletal muscle denervation, protect mitochondria, and inhibit the proapoptotic pathway in SOD1(G93A) mice.	Trehalose	36-45	superoxide dismutase 1, soluble	Mus musculus	148-152
24441414-9	2014	Collectively, our study indicated that the MTOR-independent autophagic inducer trehalose is neuroprotective in the ALS model and autophagosome-lysosome fusion is a possible therapeutic target for the treatment of ALS.	Trehalose	79-88	mechanistic target of rapamycin kinase	Mus musculus	43-47
28357229-2	2014	Upon addition of glucose, cells with a defect in trehalose 6-phosphate synthase (Tps1), the first committed step in the trehalose pathway, display what we have termed an imbalanced glycolytic state; in this state the flux through the upper part of glycolysis outpaces that through the lower part of glycolysis.	Trehalose	49-58	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	81-85
24448628-2	2014	Lentztrehalose is only weakly hydrolyzed by the trehalose-hydrolyzing enzyme, trehalase, so can be regarded as an enzyme-stable analog of trehalose.	Trehalose	5-14	trehalase (brush-border membrane glycoprotein)	Mus musculus	78-87
24448628-2	2014	Lentztrehalose is only weakly hydrolyzed by the trehalose-hydrolyzing enzyme, trehalase, so can be regarded as an enzyme-stable analog of trehalose.	Trehalose	48-57	trehalase (brush-border membrane glycoprotein)	Mus musculus	78-87
24142427-0	2014	The trehalose utilization gene thuA ortholog in Mesorhizobium loti does not influence competitiveness for nodulation on Lotus spp.	Trehalose	4-13	trehalose utilization protein ThuA	Sinorhizobium meliloti 1021	31-35
24142427-2	2014	In Sinorhizobium meliloti 1021 mutation in either of the trehalose utilization genes thuA or thuB influences its competitiveness for root colonization and nodule occupancy depending on the interacting host.	Trehalose	57-66	trehalose utilization protein ThuA	Sinorhizobium meliloti 1021	85-89
24142427-2	2014	In Sinorhizobium meliloti 1021 mutation in either of the trehalose utilization genes thuA or thuB influences its competitiveness for root colonization and nodule occupancy depending on the interacting host.	Trehalose	57-66	Gfo/Idh/MocA family oxidoreductase	Sinorhizobium meliloti 1021	93-97
24142427-5	2014	The thuA gene in M. loti was not induced during root colonization or in the infection threads unlike in S. meliloti, despite its induction by trehalose and high osmolarity in in vitro assays.	Trehalose	142-151	trehalose utilization protein ThuA	Sinorhizobium meliloti 1021	4-8
24365749-6	2014	Treatment with trehalose significantly protected animals from I/R injury and inhibited IgM-mediated complement activation although it did not prevent membrane lipid peroxidation.	Trehalose	15-24	immunoglobulin heavy constant mu	Mus musculus	87-90
24625756-7	2014	In addition, four potential disease-associated paths were identified, including two direct longitudinal predictive relationships: NAT8 with N-acetylornithine, N-acetyl-1-methylhistidine and incident chronic kidney disease, and TREH with trehalose and incident diabetes.	Trehalose	237-246	trehalase	Homo sapiens	227-231
24587280-8	2014	Treatment with trehalose counteracts the increase in ROS, ubiquitinated proteins, huntingtin and activated caspase-3 levels induced by epoxomicin, and also increases the LC3 levels more in HD fibroblast than controls.	Trehalose	15-24	huntingtin	Homo sapiens	82-92
24587280-8	2014	Treatment with trehalose counteracts the increase in ROS, ubiquitinated proteins, huntingtin and activated caspase-3 levels induced by epoxomicin, and also increases the LC3 levels more in HD fibroblast than controls.	Trehalose	15-24	caspase 3	Homo sapiens	107-116
24587280-8	2014	Treatment with trehalose counteracts the increase in ROS, ubiquitinated proteins, huntingtin and activated caspase-3 levels induced by epoxomicin, and also increases the LC3 levels more in HD fibroblast than controls.	Trehalose	15-24	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	170-173
24505621-7	2014	Additionally, while the autophagy inhibitor chloroquine had no effect, significant neuroprotection was seen instead with two drugs that enhance autophagy induction by different mechanisms, rapamycin (mTOR-dependent) and trehalose (mTOR-independent).	Trehalose	220-229	mechanistic target of rapamycin kinase	Homo sapiens	231-235
24529069-9	2014	Proteins Tsl1 and Tps3 (trehalose synthase complex regulatory subunit TSL1 and TPS3) represent the trehalose synthesis complex and they are expressed using constant, age-dependent and stochastic terms.	Trehalose	24-33	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	9-13
24529069-9	2014	Proteins Tsl1 and Tps3 (trehalose synthase complex regulatory subunit TSL1 and TPS3) represent the trehalose synthesis complex and they are expressed using constant, age-dependent and stochastic terms.	Trehalose	24-33	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	18-22
24529069-9	2014	Proteins Tsl1 and Tps3 (trehalose synthase complex regulatory subunit TSL1 and TPS3) represent the trehalose synthesis complex and they are expressed using constant, age-dependent and stochastic terms.	Trehalose	24-33	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	70-74
24291767-0	2014	FTIR, ESI-MS, VT-NMR and SANS study of trehalose thermal stabilization of lysozyme.	Trehalose	39-48	USH1 protein network component sans	Homo sapiens	25-29
24291767-0	2014	FTIR, ESI-MS, VT-NMR and SANS study of trehalose thermal stabilization of lysozyme.	Trehalose	39-48	lysozyme	Homo sapiens	74-82
24291767-2	2014	Data obtained in our experimental work indicate that trehalose (1.0M) effectively prevent thermal inactivation and aggregation of lysozyme.	Trehalose	53-62	lysozyme	Homo sapiens	130-138
24465983-1	2014	The purpose of this study was to investigate the stability of lysozyme in aqueous solutions in the presence of various extremolytes (betaine, hydroxyectoine, trehalose, ectoine, and firoin) under different stress conditions.	Trehalose	158-167	lysozyme	Homo sapiens	62-70
24465983-3	2014	During heat shock (10 min at 70 C), betaine, trehalose, ectoin and firoin protected lysozyme against inactivation while hydroxyectoine, did not have a significant effect.	Trehalose	45-54	lysozyme	Homo sapiens	84-92
24465983-5	2014	In contrast, betaine, hydroxyectoine, trehalose and ectoine destabilized lysozyme under this condition.	Trehalose	38-47	lysozyme	Homo sapiens	73-81
24291007-1	2014	Trehalose 6-phosphate synthase (TPS1) and trehalose 6-phosphate phosphatase (TPS2) are required for trehalose biosynthesis in yeast and filamentous fungi, including Fusarium graminearum.	Trehalose	42-51	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	77-81
23899046-7	2013	In addition, trehalose cleared the fibrillation by changing the surface hydrophobic interaction of A53T alpha-synuclein, which did not show any inhibition effect from WT alpha-synuclein.	Trehalose	13-22	synuclein alpha	Homo sapiens	104-119
24789922-3	2014	In comparison with the NI-SLNs, the NI-SLNs lyophilized with trehalose (NI-SLN-Tre) showed a slight increase in the particle size from 68.5 to 107.7 nm, but the PDI decreased from 0.38 to 0.33, and no significant change in zeta potential was observed.	Trehalose	61-70	tRNA-Glu (anticodon TTC) 3-1	Homo sapiens	79-82
24789922-7	2014	Finally, a stability study was performed with NI-SLN-Tre for up to 6 months at 30 C and 65% relative humidity, with no significant deterioration observed, suggesting that trehalose might be a useful cryoprotectant for NI-SLNs.	Trehalose	171-180	sarcolipin	Homo sapiens	49-52
24789922-7	2014	Finally, a stability study was performed with NI-SLN-Tre for up to 6 months at 30 C and 65% relative humidity, with no significant deterioration observed, suggesting that trehalose might be a useful cryoprotectant for NI-SLNs.	Trehalose	171-180	tRNA-Glu (anticodon TTC) 3-1	Homo sapiens	53-56
25273988-4	2014	Both TPS1 genes contributed to the high level of intracellular trehalose as a 3.4-fold decrease resulted from the disruption of one of the two TPS1 genes.	Trehalose	63-72	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	5-9
25273988-4	2014	Both TPS1 genes contributed to the high level of intracellular trehalose as a 3.4-fold decrease resulted from the disruption of one of the two TPS1 genes.	Trehalose	63-72	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	143-147
25273988-5	2014	Both Msn2 and Msn4, which bind to stress responsive elements in the promoter region of TPS1, were required for production of high levels of trehalose.	Trehalose	140-149	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	5-9
25273988-5	2014	Both Msn2 and Msn4, which bind to stress responsive elements in the promoter region of TPS1, were required for production of high levels of trehalose.	Trehalose	140-149	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	14-18
25273988-5	2014	Both Msn2 and Msn4, which bind to stress responsive elements in the promoter region of TPS1, were required for production of high levels of trehalose.	Trehalose	140-149	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	87-91
25273988-7	2014	These findings indicate that two TPS1 genes and the low trehalase activity are associated with high trehalose accumulation in this spore clone.	Trehalose	100-109	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	33-37
24101491-1	2013	Mincle [macrophage inducible Ca(2+)-dependent (C-type) lectin; CLEC4E] and MCL (macrophage C-type lectin; CLEC4D) are receptors for the cord factor TDM (trehalose-6,6"-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activate immune cells to confer adjuvant activity.	Trehalose	153-162	C-type lectin domain family 4 member E	Homo sapiens	0-6
24101491-1	2013	Mincle [macrophage inducible Ca(2+)-dependent (C-type) lectin; CLEC4E] and MCL (macrophage C-type lectin; CLEC4D) are receptors for the cord factor TDM (trehalose-6,6"-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activate immune cells to confer adjuvant activity.	Trehalose	153-162	C-type lectin domain family 4 member E	Homo sapiens	63-69
24101491-1	2013	Mincle [macrophage inducible Ca(2+)-dependent (C-type) lectin; CLEC4E] and MCL (macrophage C-type lectin; CLEC4D) are receptors for the cord factor TDM (trehalose-6,6"-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activate immune cells to confer adjuvant activity.	Trehalose	153-162	C-type lectin domain family 4 member D	Homo sapiens	75-78
24101491-1	2013	Mincle [macrophage inducible Ca(2+)-dependent (C-type) lectin; CLEC4E] and MCL (macrophage C-type lectin; CLEC4D) are receptors for the cord factor TDM (trehalose-6,6"-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activate immune cells to confer adjuvant activity.	Trehalose	153-162	C-type lectin domain family 4 member D	Homo sapiens	80-104
24101491-1	2013	Mincle [macrophage inducible Ca(2+)-dependent (C-type) lectin; CLEC4E] and MCL (macrophage C-type lectin; CLEC4D) are receptors for the cord factor TDM (trehalose-6,6"-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activate immune cells to confer adjuvant activity.	Trehalose	153-162	C-type lectin domain family 4 member D	Homo sapiens	106-112
24188107-2	2013	VEGF and HGF were lyophilized separately with trehalose and bovine serum albumin (BSA) and incorporated into the polymer by simple mixing.	Trehalose	46-55	vascular endothelial growth factor A	Homo sapiens	0-4
24236985-0	2013	Trehalose rescues Alzheimer"s disease phenotypes in APP/PS1 transgenic mice.	Trehalose	0-9	presenilin 1	Mus musculus	56-59
24236985-4	2013	METHODS: In this study, we evaluated the effects of trehalose in APP/PS1 transgenic mice through behaviour tests and biochemical analyses.	Trehalose	52-61	presenilin 1	Mus musculus	69-72
23810450-9	2013	Interestingly, trehalose, a well-known autophagy stimulator, induces HspB8 expression, suggesting that HspB8 might act as one of the molecular mediators of the proautophagic activity of trehalose.	Trehalose	15-24	heat shock protein family B (small) member 8	Homo sapiens	69-74
23810450-9	2013	Interestingly, trehalose, a well-known autophagy stimulator, induces HspB8 expression, suggesting that HspB8 might act as one of the molecular mediators of the proautophagic activity of trehalose.	Trehalose	15-24	heat shock protein family B (small) member 8	Homo sapiens	103-108
23810450-9	2013	Interestingly, trehalose, a well-known autophagy stimulator, induces HspB8 expression, suggesting that HspB8 might act as one of the molecular mediators of the proautophagic activity of trehalose.	Trehalose	186-195	heat shock protein family B (small) member 8	Homo sapiens	69-74
23810450-9	2013	Interestingly, trehalose, a well-known autophagy stimulator, induces HspB8 expression, suggesting that HspB8 might act as one of the molecular mediators of the proautophagic activity of trehalose.	Trehalose	186-195	heat shock protein family B (small) member 8	Homo sapiens	103-108
23899046-8	2013	The results proved that the interpeptide hydrophobic interactions in the elongation of A53T alpha-synuclein protofilaments can be greatly weakened by trehalose.	Trehalose	150-159	synuclein alpha	Homo sapiens	92-107
23763276-7	2013	Hyperaccumulation of T6P in the tps2 mutant caused an increase in cytosolic pH and strongly reduced growth rates on non-fermentable carbon sources, emphasizing the crucial role of the trehalose pathway in the regulation of respiratory and fermentative metabolism.	Trehalose	184-193	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	32-36
23793638-8	2013	Using low-strength promoters active at different stages of fermentation, the expression of the TPS1 gene was slightly upregulated, resulting in a decrease in ethanol production and an increase in trehalose biosynthesis during fermentation.	Trehalose	196-205	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	95-99
23608455-6	2013	These animals are able to counteract the increased levels of circulating trehalose induced by a high sugar diet leading to the conclusion that dMyc activity in the FB promotes glucose disposal.	Trehalose	73-82	Myc	Drosophila melanogaster	143-147
23751979-6	2013	Mutant strains lacking TPS1, which encodes a putative trehalose-6-phosphate synthase, have altered growth characteristics, do not produce detectable amounts of trehalose under any condition tested, and accumulate glycogen at levels significantly higher than wild-type F. verticillioides.	Trehalose	54-63	acyclic sesquiterpene synthase	Zea mays	23-27
23851366-5	2013	In this report, we tested the potential use of trehalose, a disaccharide that induces MTOR-independent autophagy, in the development of experimental ALS.	Trehalose	47-56	mechanistic target of rapamycin kinase	Mus musculus	86-90
23851366-6	2013	Administration of trehalose to mutant SOD1 transgenic mice significantly prolonged life span and attenuated the progression of disease signs.	Trehalose	18-27	superoxide dismutase 1, soluble	Mus musculus	38-42
23851366-9	2013	Cell culture experiments demonstrated that trehalose led to mutant SOD1 degradation by autophagy in NSC34 motoneuron cells and also protected primary motoneurons against the toxicity of conditioned media from mutant SOD1 transgenic astrocytes.	Trehalose	43-52	superoxide dismutase 1, soluble	Mus musculus	67-71
23851366-9	2013	Cell culture experiments demonstrated that trehalose led to mutant SOD1 degradation by autophagy in NSC34 motoneuron cells and also protected primary motoneurons against the toxicity of conditioned media from mutant SOD1 transgenic astrocytes.	Trehalose	43-52	superoxide dismutase 1, soluble	Mus musculus	216-220
23851366-10	2013	At the mechanistic level, trehalose treatment led to a significant upregulation in the expression of key autophagy-related genes at the mRNA level including Lc3, Becn1, Sqstm1 and Atg5.	Trehalose	26-35	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	157-160
23851366-10	2013	At the mechanistic level, trehalose treatment led to a significant upregulation in the expression of key autophagy-related genes at the mRNA level including Lc3, Becn1, Sqstm1 and Atg5.	Trehalose	26-35	beclin 1, autophagy related	Mus musculus	162-167
23851366-10	2013	At the mechanistic level, trehalose treatment led to a significant upregulation in the expression of key autophagy-related genes at the mRNA level including Lc3, Becn1, Sqstm1 and Atg5.	Trehalose	26-35	sequestosome 1	Mus musculus	169-175
23851366-10	2013	At the mechanistic level, trehalose treatment led to a significant upregulation in the expression of key autophagy-related genes at the mRNA level including Lc3, Becn1, Sqstm1 and Atg5.	Trehalose	26-35	autophagy related 5	Mus musculus	180-184
23851366-11	2013	Consistent with these changes, trehalose administration enhanced the nuclear translocation of FOXO1, an important transcription factor involved in the activation of autophagy in neurons.	Trehalose	31-40	forkhead box O1	Mus musculus	94-99
23644913-7	2013	RESULTS: Chronic administration of trehalose resulted in a reduction of frontal cortex p62/beclin-1 ratio suggesting enhancement of autophagy.	Trehalose	35-44	nucleoporin 62	Mus musculus	87-90
23644913-7	2013	RESULTS: Chronic administration of trehalose resulted in a reduction of frontal cortex p62/beclin-1 ratio suggesting enhancement of autophagy.	Trehalose	35-44	beclin 1, autophagy related	Mus musculus	91-99
23597844-8	2013	In addition, the mutant with NTH1 deletion exhibits a higher trehalose accumulation and consequently displays a higher viability of yeast cells after freezing.	Trehalose	61-70	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	29-33
23184705-0	2013	Spectroscopic determination of lysozyme conformational changes in the presence of trehalose and guanidine.	Trehalose	82-91	lysozyme	Homo sapiens	31-39
23184705-2	2013	The results indicated a direct influence of trehalose on both enzymatic activity and conformational changes of lysozyme, as shown by the decrease of the inactivation rate constant of about 1.48-fold and the loss of alpha-helix structure of lysozyme.	Trehalose	44-53	lysozyme	Homo sapiens	111-119
23184705-2	2013	The results indicated a direct influence of trehalose on both enzymatic activity and conformational changes of lysozyme, as shown by the decrease of the inactivation rate constant of about 1.48-fold and the loss of alpha-helix structure of lysozyme.	Trehalose	44-53	lysozyme	Homo sapiens	240-248
23341362-3	2013	AtTRE1 encodes the Arabidopsis trehalase, the only enzyme known in this species to specifically hydrolyze trehalose into glucose.	Trehalose	106-115	trehalase 1	Arabidopsis thaliana	0-6
23500430-0	2013	Myelin basic protein: structural characterization of spherulites formation and preventive action of trehalose.	Trehalose	100-109	myelin basic protein	Homo sapiens	0-20
23500430-6	2013	Moreover, study of protein conformational states by SDS-PAGE, let us to state that trehalose completely avoid autocatalytic cleavage properties of MBP up to 4 days of incubation at 37  C and pH 7.4.	Trehalose	83-92	myelin basic protein	Homo sapiens	147-150
23667480-2	2013	We have recently shown that trehalose reduces tau pathology in a tauopathy mouse model by stimulation of autophagy.	Trehalose	28-37	microtubule associated protein tau	Homo sapiens	46-49
23754959-0	2013	Juvenile hormone and insulin regulate trehalose homeostasis in the red flour beetle, Tribolium castaneum.	Trehalose	38-47	insulin	Bos taurus	21-28
23713139-11	2013	Advantages of the GAP1 population include amino acid uptake, fast energy recruitment by trehalose mobilization, and in some cases, adherent biofilm growth.	Trehalose	88-97	amino acid permease GAP1	Saccharomyces cerevisiae S288C	18-22
23341362-5	2013	AtTRE1-overexpressing plants had decreased trehalose levels and recovered better after drought stress, whereas Attre1 mutants had elevated trehalose contents and exhibited a drought-susceptible phenotype.	Trehalose	43-52	trehalase 1	Arabidopsis thaliana	0-6
23341362-5	2013	AtTRE1-overexpressing plants had decreased trehalose levels and recovered better after drought stress, whereas Attre1 mutants had elevated trehalose contents and exhibited a drought-susceptible phenotype.	Trehalose	139-148	trehalase 1	Arabidopsis thaliana	111-117
23158184-7	2012	Autophagy protein 5 silencing abrogated both everolimus- and trehalose-induced increases in tyrosine kinase inhibitor efficacy.	Trehalose	61-70	autophagy related 5	Homo sapiens	0-19
23357588-4	2013	To improve trehalose production, bovine serum albumin was co-aggregated with enzymes as a proteic feeder.	Trehalose	11-20	albumin	Homo sapiens	40-53
24240988-8	2013	Conversely, increasing LC3-II availability by silencing the cysteine protease ATG4B or acute trehalose exposure increases ERK phosphorylation.	Trehalose	93-102	mitogen-activated protein kinase 1	Homo sapiens	122-125
22955841-2	2012	The insect BFC is based on trehalase and glucose oxidase (GOD) reaction systems which oxidize beta-glucose obtained by hydrolyzing trehalose.	Trehalose	131-140	trehalase	Homo sapiens	27-36
23404569-0	2013	The effect of complex solvents on the structure and dynamics of protein solutions: The case of Lysozyme in trehalose/water mixtures.	Trehalose	107-116	lysozyme	Homo sapiens	95-103
23212707-0	2013	Trehalose preserves the integrity of lyophilized phycoerythrin-antihuman CD8 antibody conjugates and enhances their thermal stability in flow cytometric assays.	Trehalose	0-9	CD8a molecule	Homo sapiens	73-76
23212707-3	2013	We tested the ability of trehalose in protecting R-Phycoerythrin (R-PE), a pigment-protein complex widely used as fluorescent marker, from thermal denaturation.	Trehalose	25-34	ribulose-5-phosphate-3-epimerase	Homo sapiens	49-70
23212707-5	2013	We subsequently examined the protection exerted by trehalose on freeze-dried antihuman CD8-RPE (CD8-RPE) conjugated antibodies.	Trehalose	51-60	CD8a molecule	Homo sapiens	87-90
23212707-5	2013	We subsequently examined the protection exerted by trehalose on freeze-dried antihuman CD8-RPE (CD8-RPE) conjugated antibodies.	Trehalose	51-60	CD8a molecule	Homo sapiens	96-99
23212707-6	2013	Flow cytometric analysis showed that colyophilized trehalose-CD8-RPE preparations can be exposed for 4 weeks at 45 C without significant loss of functionality.	Trehalose	51-60	CD8a molecule	Homo sapiens	61-64
23137283-9	2013	Gene expressions of tumour necrosis factor-alpha, RANKL and toll-like receptor 4 were suppressed by trehalose.	Trehalose	100-109	TNF superfamily member 11	Rattus norvegicus	50-55
23137283-9	2013	Gene expressions of tumour necrosis factor-alpha, RANKL and toll-like receptor 4 were suppressed by trehalose.	Trehalose	100-109	toll-like receptor 4	Rattus norvegicus	60-80
23137283-10	2013	In addition, protein expressions of RANKL inducing pathway were less activated by trehalose.	Trehalose	82-91	TNF superfamily member 11	Rattus norvegicus	36-41
23137283-11	2013	CONCLUSION: Topical application of trehalose could suppress osteoclast differentiation by inactivation of RANKL inducing pathway in the rat periodontitis model.	Trehalose	35-44	TNF superfamily member 11	Rattus norvegicus	106-111
24418873-7	2013	The expression levels of insulin receptor substrate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) messenger RNA (mRNA) in muscle were also significantly increased by trehalose intake.	Trehalose	171-180	insulin receptor substrate 1	Mus musculus	25-53
24418873-7	2013	The expression levels of insulin receptor substrate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) messenger RNA (mRNA) in muscle were also significantly increased by trehalose intake.	Trehalose	171-180	insulin receptor substrate 1	Mus musculus	55-60
24418873-7	2013	The expression levels of insulin receptor substrate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) messenger RNA (mRNA) in muscle were also significantly increased by trehalose intake.	Trehalose	171-180	insulin receptor substrate 2	Mus musculus	66-94
24418873-7	2013	The expression levels of insulin receptor substrate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) messenger RNA (mRNA) in muscle were also significantly increased by trehalose intake.	Trehalose	171-180	insulin receptor substrate 2	Mus musculus	96-101
24418873-8	2013	Our data therefore suggest that administration of trehalose to obese mice mitigates insulin resistance by suppressing adipocyte hypertrophy and increasing serum HMW adiponectin, resulting in upregulation of IRS-1, and IRS-2 expression in muscle.	Trehalose	50-59	adiponectin, C1Q and collagen domain containing	Mus musculus	165-176
24418873-8	2013	Our data therefore suggest that administration of trehalose to obese mice mitigates insulin resistance by suppressing adipocyte hypertrophy and increasing serum HMW adiponectin, resulting in upregulation of IRS-1, and IRS-2 expression in muscle.	Trehalose	50-59	insulin receptor substrate 1	Mus musculus	207-212
24418873-8	2013	Our data therefore suggest that administration of trehalose to obese mice mitigates insulin resistance by suppressing adipocyte hypertrophy and increasing serum HMW adiponectin, resulting in upregulation of IRS-1, and IRS-2 expression in muscle.	Trehalose	50-59	insulin receptor substrate 2	Mus musculus	218-223
23121215-2	2013	It has been proposed that trehalose content in nodules during this symbiotic interaction might be regulated by trehalase.	Trehalose	26-35	trehalase	Homo sapiens	111-120
23121215-3	2013	In the present study, we assessed the role of trehalose accumulation by down-regulating trehalase in the nodules of common bean plants.	Trehalose	46-55	trehalase	Homo sapiens	88-97
23408980-6	2013	Moreover, the results obtained suggest that the reported action of Fps1 in mediating the passive diffusion of glycerol is a key factor in the maintenance of redox balance, an important feature for ethanol stress resistance, and may interfere with the ability of the yeast cell to accumulate trehalose.	Trehalose	291-300	Fps1p	Saccharomyces cerevisiae S288C	67-71
23359400-0	2013	Trehalose maintains bioactivity and promotes sustained release of BMP-2 from lyophilized CDHA scaffolds for enhanced osteogenesis in vitro and in vivo.	Trehalose	0-9	bone morphogenetic protein 2	Rattus norvegicus	66-71
23359400-3	2013	In present study, a new delivery system was fabricated using bone morphogenetic protein-2 (BMP-2) loaded calcium-deficient hydroxyapatite (CDHA) scaffold by lyophilization with addition of trehalose.	Trehalose	189-198	bone morphogenetic protein 2	Rattus norvegicus	61-89
23359400-3	2013	In present study, a new delivery system was fabricated using bone morphogenetic protein-2 (BMP-2) loaded calcium-deficient hydroxyapatite (CDHA) scaffold by lyophilization with addition of trehalose.	Trehalose	189-198	bone morphogenetic protein 2	Rattus norvegicus	91-96
23359400-5	2013	The release characteristics and alkaline phosphatase (ALP) activity analyses showed that addition of trehalose could sufficiently protect BMP-2 bioactivity during lyophilization and achieve sustained BMP-2 release from lyophilized CDHA construct in vitro and in vivo.	Trehalose	101-110	bone morphogenetic protein 2	Rattus norvegicus	138-143
23359400-5	2013	The release characteristics and alkaline phosphatase (ALP) activity analyses showed that addition of trehalose could sufficiently protect BMP-2 bioactivity during lyophilization and achieve sustained BMP-2 release from lyophilized CDHA construct in vitro and in vivo.	Trehalose	101-110	bone morphogenetic protein 2	Rattus norvegicus	200-205
23359400-6	2013	However, absorbed BMP-2/CDHA constructs with or without trehalose showed similar BMP-2 bioactivity and presented a burst release.	Trehalose	56-65	bone morphogenetic protein 2	Rattus norvegicus	18-23
23359400-6	2013	However, absorbed BMP-2/CDHA constructs with or without trehalose showed similar BMP-2 bioactivity and presented a burst release.	Trehalose	56-65	bone morphogenetic protein 2	Rattus norvegicus	81-86
23390573-3	2013	Comparing aqueous solutions of lysozyme with/without trehalose, we observe that the dynamics of water in the hydration layers close to the protein is dramatically slower when trehalose is present in the system.	Trehalose	175-184	lysozyme	Homo sapiens	31-39
23390573-4	2013	We also analyze the structure of water and trehalose around the lysozyme and find that the trehalose molecules form a cage surrounding the protein that contains very slow water molecules.	Trehalose	43-52	lysozyme	Homo sapiens	64-72
23390573-4	2013	We also analyze the structure of water and trehalose around the lysozyme and find that the trehalose molecules form a cage surrounding the protein that contains very slow water molecules.	Trehalose	91-100	lysozyme	Homo sapiens	64-72
22855938-3	2012	Trehalose biosynthesis in plants involves a two-step reaction in which trehalose-6-phosphate (T6P) is synthesized from UDP-glucose and glucose-6-phosphate (catalyzed by T6P synthase [TPS]), and subsequently dephosphorylated to produce the disaccharide trehalose (catalyzed by T6P phosphatase [TPP]).	Trehalose	0-9	thylakoid processing peptide	Arabidopsis thaliana	276-291
22952228-6	2012	We demonstrate a novel regulatory mechanism of heat- and Hsp90-dependent induced morphogenesis, whereby the nonreducing disaccharide trehalose acts as a negative regulator of Hsp90 release.	Trehalose	133-142	heat shock protein 90 alpha family class A member 1	Homo sapiens	57-62
22952228-6	2012	We demonstrate a novel regulatory mechanism of heat- and Hsp90-dependent induced morphogenesis, whereby the nonreducing disaccharide trehalose acts as a negative regulator of Hsp90 release.	Trehalose	133-142	heat shock protein 90 alpha family class A member 1	Homo sapiens	175-180
22952228-10	2012	These results place Gpr1 as a regulator of trehalose metabolism in C. albicans and illustrate that trehalose modulates Hsp90-dependent activation of client proteins and signaling pathways leading to filamentation in the human fungal pathogen.	Trehalose	99-108	heat shock protein 90 alpha family class A member 1	Homo sapiens	119-124
22845790-0	2012	Thermal aggregation of bovine serum albumin in trehalose and sucrose aqueous solutions.	Trehalose	47-56	albumin	Homo sapiens	30-43
22845790-1	2012	We report results of static and dynamic light scattering measurements performed on bovine serum albumin (BSA) in saccharide (trehalose and sucrose) solutions.	Trehalose	125-134	albumin	Homo sapiens	90-103
22966849-7	2012	Furthermore, the membrane dissociation of Syt7 C2A but not Syt1 C2A is slowed by Na(2)SO(4) and trehalose, solutes that enhance the hydrophobic effect.	Trehalose	96-105	synaptotagmin 7	Homo sapiens	42-46
23507897-8	2012	After freeze-drying with cryoprotectants, the amount of insulin released was higher for trehalose and lower for sucrose, glucose, fructose and sorbitol comparatively to freeze-dried PLGA-NP with no cryoprotectant added.	Trehalose	88-97	insulin	Homo sapiens	56-63
23257456-6	2012	Flow cytometry data demonstrated that incubation of RBC in a hypertonic trehalose solution resulted in a fraction of cells with different complexity that attached to little Annexin V-FITC, and that it could be removed by washing and resuspending the RBC in an iso-osmotic (300 mOsm PBS) medium.	Trehalose	72-81	annexin A5	Homo sapiens	173-182
22874558-5	2012	In the brain of the trehalose-treated mutant mice, autophagy is activated and a reduced number of neurons containing MAPT inclusions, as well as a decreased amount of insoluble MAPT, are observed.	Trehalose	20-29	microtubule associated protein tau	Homo sapiens	117-121
22874558-5	2012	In the brain of the trehalose-treated mutant mice, autophagy is activated and a reduced number of neurons containing MAPT inclusions, as well as a decreased amount of insoluble MAPT, are observed.	Trehalose	20-29	microtubule associated protein tau	Homo sapiens	177-181
22850292-6	2012	Second we tested the effect of 6 naturally occurring extremolytes (trehalose, sucrose, ectoine, hydroxyectoine, sorbitol, mannitol) on the thermal stability of G-CSF, using a central composite circumscribed design.	Trehalose	67-76	colony stimulating factor 3	Homo sapiens	160-165
22855938-3	2012	Trehalose biosynthesis in plants involves a two-step reaction in which trehalose-6-phosphate (T6P) is synthesized from UDP-glucose and glucose-6-phosphate (catalyzed by T6P synthase [TPS]), and subsequently dephosphorylated to produce the disaccharide trehalose (catalyzed by T6P phosphatase [TPP]).	Trehalose	0-9	thylakoid processing peptide	Arabidopsis thaliana	293-296
22855938-3	2012	Trehalose biosynthesis in plants involves a two-step reaction in which trehalose-6-phosphate (T6P) is synthesized from UDP-glucose and glucose-6-phosphate (catalyzed by T6P synthase [TPS]), and subsequently dephosphorylated to produce the disaccharide trehalose (catalyzed by T6P phosphatase [TPP]).	Trehalose	71-80	thylakoid processing peptide	Arabidopsis thaliana	276-291
22855938-3	2012	Trehalose biosynthesis in plants involves a two-step reaction in which trehalose-6-phosphate (T6P) is synthesized from UDP-glucose and glucose-6-phosphate (catalyzed by T6P synthase [TPS]), and subsequently dephosphorylated to produce the disaccharide trehalose (catalyzed by T6P phosphatase [TPP]).	Trehalose	71-80	thylakoid processing peptide	Arabidopsis thaliana	293-296
22855938-11	2012	Consistently, phenotypic characterization of knockdown and overexpression lines of a single TPP, AtTPPG, points to unique properties of individual TPPs in Arabidopsis, and underlines the intimate connection between trehalose metabolism and abscisic acid signaling.	Trehalose	215-224	thylakoid processing peptide	Arabidopsis thaliana	92-95
22762304-1	2012	Trehalose phosphate synthase (EC 2.4.1.15; TPS) is the crucial enzyme for the biosynthesis of trehalose, the main haemolymph sugar of insects, and therefore a potential insecticidal molecular target.	Trehalose	94-103	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	43-46
22894179-6	2012	Accordingly, the low-frequency vibrational densities of states (VDOS) and the mean square displacements (MSDs) of lysozyme reveal that it is less flexible-and thus less likely to unfold-in the presence of trehalose.	Trehalose	205-214	lysozyme	Homo sapiens	114-122
22894179-9	2012	Moreover, lysozyme interacts preferentially with water in the hydrated LT mixtures, and trehalose appears to slow down significantly the relaxation of lysozyme-water HBs.	Trehalose	88-97	lysozyme	Homo sapiens	151-159
22707286-0	2012	Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant alpha-synuclein.	Trehalose	10-19	synuclein alpha	Rattus norvegicus	74-89
22707286-2	2012	To assess the potential of trehalose in this regard, we investigated its effect on the PC12 cells overexpressing wild type (WT) or A53T mutant alpha-Syn and the implicated pathway it might mediated.	Trehalose	27-36	synuclein alpha	Rattus norvegicus	143-152
22707286-3	2012	We observed that trehalose promoted the clearance of A53T alpha-Syn but not WT alpha-Syn in PC12 cells, and confirmed the increased LC3 and Lysotracker RED positive autolysosomes by using lysotracker and LC3 staining, the enhanced expression of LC3-II in Western blot, and more autophagosomes under Transmission Electron Microscope in a dose dependent manner after the trehalose treatment.	Trehalose	17-26	synuclein alpha	Rattus norvegicus	58-67
22707286-6	2012	But the effect of trehalose on A53T alpha-Syn is mainly mediated through the macroautophagy pathway, which is not a dominant way for WT alpha-Syn clearance.	Trehalose	18-27	synuclein alpha	Rattus norvegicus	36-45
22610605-3	2012	Spc1/Sty1, a mitogen/stress-activated protein kinase homologous to human p38 and Saccharomyces cerevisiae Hog1, controls many of these changes, including enzymes of the oxidative phase of the pentose phosphate pathway and trehalose metabolism.	Trehalose	222-231	signal peptidase complex subunit 1	Homo sapiens	0-4
22610605-3	2012	Spc1/Sty1, a mitogen/stress-activated protein kinase homologous to human p38 and Saccharomyces cerevisiae Hog1, controls many of these changes, including enzymes of the oxidative phase of the pentose phosphate pathway and trehalose metabolism.	Trehalose	222-231	mitogen-activated protein kinase 14	Homo sapiens	73-76
22610605-3	2012	Spc1/Sty1, a mitogen/stress-activated protein kinase homologous to human p38 and Saccharomyces cerevisiae Hog1, controls many of these changes, including enzymes of the oxidative phase of the pentose phosphate pathway and trehalose metabolism.	Trehalose	222-231	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	106-110
22894179-0	2012	How strongly does trehalose interact with lysozyme in the solid state?	Trehalose	18-27	lysozyme	Homo sapiens	42-50
22909409-0	2012	Thermal and solution stability of lysozyme in the presence of sucrose, glucose, and trehalose.	Trehalose	84-93	lysozyme	Homo sapiens	34-42
22909409-1	2012	The effect of the sugars sucrose, glucose, and trehalose on the structural and colloidal stability of lysozyme has been investigated using differential scanning calorimetry and quasi-elastic light scattering, respectively.	Trehalose	47-56	lysozyme	Homo sapiens	102-110
22575388-2	2012	Here, by using circular dichroism spectroscopy, thioflavin T fluorescence, and atomic force microscopy, we found that trehalose at low concentration disaggregates preformed A53T AS protofibrils and fibrils into small aggregates or even random coil structure, while trehalose at high concentration slows down the structural transition into beta-sheet structure and completely prevents the formation of mature A53T AS fibrils.	Trehalose	118-127	synuclein alpha	Homo sapiens	178-180
22575388-2	2012	Here, by using circular dichroism spectroscopy, thioflavin T fluorescence, and atomic force microscopy, we found that trehalose at low concentration disaggregates preformed A53T AS protofibrils and fibrils into small aggregates or even random coil structure, while trehalose at high concentration slows down the structural transition into beta-sheet structure and completely prevents the formation of mature A53T AS fibrils.	Trehalose	118-127	synuclein alpha	Homo sapiens	413-415
22575388-0	2012	Trehalose inhibits fibrillation of A53T mutant alpha-synuclein and disaggregates existing fibrils.	Trehalose	0-9	synuclein alpha	Homo sapiens	47-62
22447585-4	2012	Introduction of this mutation or deletion of the full-length RIM15 gene in a laboratory strain led to a defective stress response, decreased synthesis of the storage carbohydrates trehalose and glycogen, and impaired G(1) arrest, which together closely resemble the characteristic phenotypes of sake yeast.	Trehalose	180-189	protein kinase RIM15	Saccharomyces cerevisiae S288C	61-66
22510446-7	2012	Trehalose was shown to be the most effective additive for stabilizing NT-3 during sonication and lyophilization and PLGA itself was shown to stabilize NT-3 during these processes.	Trehalose	0-9	neurotrophin 3	Homo sapiens	70-74
22280966-3	2012	In order to enhance the freeze tolerance of yeast cells, we constructed a self-cloning diploid baker"s yeast strain with simultaneous accumulation of proline, by expressing the PRO1-I150T allele, encoding the proline-feedback inhibition-less sensitive gamma-glutamyl kinase, and trehalose, by disrupting the NTH1 gene, encoding neutral trehalase.	Trehalose	279-288	glutamate 5-kinase	Saccharomyces cerevisiae S288C	177-181
22580694-3	2012	TPS11 (TREHALOSE PHOSPHATE SYNTHASE11)-dependent trehalose metabolism was shown to curtail GPA infestation by promoting starch accumulation and expression of the PAD4 (PHYTOALEXIN-DEFICIENT4) gene, which has important roles in regulating antibiosis and antixenosis against GPA.	Trehalose	49-58	trehalose phosphatase/synthase 11	Arabidopsis thaliana	0-5
22580694-3	2012	TPS11 (TREHALOSE PHOSPHATE SYNTHASE11)-dependent trehalose metabolism was shown to curtail GPA infestation by promoting starch accumulation and expression of the PAD4 (PHYTOALEXIN-DEFICIENT4) gene, which has important roles in regulating antibiosis and antixenosis against GPA.	Trehalose	49-58	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	162-166
22203099-5	2012	To answer this question, the effect of ethylene glycol (EG), glycerol, xylitol, sorbitol, trehalose and glucose at pH 2.5 on the structure and stability of yeast hexokinase A was investigated using spectroscopy and calorimetry.	Trehalose	90-99	hexokinase	Saccharomyces cerevisiae S288C	162-172
22306041-6	2012	Co-encapsulated trehalose significantly improved anti-NogoA bioactivity at early release time points by stabilizing the protein during lyophilization.	Trehalose	16-25	reticulon 4	Rattus norvegicus	54-59
21976136-5	2012	(125) I-VEGF was colyophilized with trehalose and serum albumin and distributed as particles throughout a photo-cross-linked elastomer composed of trimethylene carbonate, epsilon-caprolactone, and d,l-lactide.	Trehalose	36-45	vascular endothelial growth factor A	Rattus norvegicus	8-12
22173278-1	2012	OBJECTIVE: The objective of this paper is to examine the role of NF-kappa B inhibitors A20 and ABIN-family proteins in the trehalose 6,6"-dimycolate (TDM)-induced model of tuberculous granulomatous lesions.	Trehalose	123-132	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	65-75
22173278-1	2012	OBJECTIVE: The objective of this paper is to examine the role of NF-kappa B inhibitors A20 and ABIN-family proteins in the trehalose 6,6"-dimycolate (TDM)-induced model of tuberculous granulomatous lesions.	Trehalose	123-132	tumor necrosis factor, alpha-induced protein 3	Mus musculus	87-90
22173278-1	2012	OBJECTIVE: The objective of this paper is to examine the role of NF-kappa B inhibitors A20 and ABIN-family proteins in the trehalose 6,6"-dimycolate (TDM)-induced model of tuberculous granulomatous lesions.	Trehalose	123-132	TNFAIP3 interacting protein 1	Mus musculus	95-99
22228409-8	2012	The AtSUS2 promoter was induced in planta by feeding of glucose but less so by sucrose and trehalose.	Trehalose	91-100	Pre-mRNA-processing-splicing factor	Arabidopsis thaliana	4-10
22345491-7	2012	Metabolite profiling identified elevated Pro and trehalose levels in JUB1 overexpressors, in accordance with their enhanced abiotic stress tolerance.	Trehalose	49-58	NAC domain containing protein 42	Arabidopsis thaliana	69-73
21964250-6	2012	In particular, we tested 17-AAG, ibuprofen, 4-PBA, curcumin, trehalose, congo red and chrysamine G for their ability to i) recover the nuclear localisation of polyAla expanded PHOX2B, ii) rescue of PHOX2B mediated transactivation of the DBH promoter, and iii) clearance of PHOX2B (+13 Ala) aggregates.	Trehalose	61-70	paired like homeobox 2B	Homo sapiens	176-182
22355243-13	2012	The group treated with trehalose showed a similar profile expression of HSP70 and MMP-9 as the control group (UT).	Trehalose	23-32	heat shock protein 1B	Mus musculus	72-77
22355243-13	2012	The group treated with trehalose showed a similar profile expression of HSP70 and MMP-9 as the control group (UT).	Trehalose	23-32	matrix metallopeptidase 9	Mus musculus	82-87
22355243-15	2012	CONCLUSIONS: Trehalose application restored ocular surface integrity, suppressed inflammatory and proteolytic MMP-9 and HSP70 expression, and keratinization in mice with dry eye damaged by a desiccative model.	Trehalose	13-22	matrix metallopeptidase 9	Mus musculus	110-115
22355243-15	2012	CONCLUSIONS: Trehalose application restored ocular surface integrity, suppressed inflammatory and proteolytic MMP-9 and HSP70 expression, and keratinization in mice with dry eye damaged by a desiccative model.	Trehalose	13-22	heat shock protein 1B	Mus musculus	120-125
21964250-6	2012	In particular, we tested 17-AAG, ibuprofen, 4-PBA, curcumin, trehalose, congo red and chrysamine G for their ability to i) recover the nuclear localisation of polyAla expanded PHOX2B, ii) rescue of PHOX2B mediated transactivation of the DBH promoter, and iii) clearance of PHOX2B (+13 Ala) aggregates.	Trehalose	61-70	paired like homeobox 2B	Homo sapiens	198-204
21964250-6	2012	In particular, we tested 17-AAG, ibuprofen, 4-PBA, curcumin, trehalose, congo red and chrysamine G for their ability to i) recover the nuclear localisation of polyAla expanded PHOX2B, ii) rescue of PHOX2B mediated transactivation of the DBH promoter, and iii) clearance of PHOX2B (+13 Ala) aggregates.	Trehalose	61-70	dopamine beta-hydroxylase	Homo sapiens	237-240
21964250-6	2012	In particular, we tested 17-AAG, ibuprofen, 4-PBA, curcumin, trehalose, congo red and chrysamine G for their ability to i) recover the nuclear localisation of polyAla expanded PHOX2B, ii) rescue of PHOX2B mediated transactivation of the DBH promoter, and iii) clearance of PHOX2B (+13 Ala) aggregates.	Trehalose	61-70	paired like homeobox 2B	Homo sapiens	198-204
22116763-9	2011	Knockdown of DTKR in IPCs leads to increased lifespan and a faster decrease of trehalose at starvation but has no significant effect on lipid levels.	Trehalose	79-88	Tachykinin-like receptor at 99D	Drosophila melanogaster	13-17
22905132-1	2012	Trehalose-6-phosphate synthase (TPS) plays important roles in trehalose metabolism and signaling.	Trehalose	62-71	trehalose-6-phosphate synthase	Arabidopsis thaliana	0-30
22905132-1	2012	Trehalose-6-phosphate synthase (TPS) plays important roles in trehalose metabolism and signaling.	Trehalose	62-71	trehalose-6-phosphate synthase	Arabidopsis thaliana	32-35
22589700-7	2012	We identify several gene products that are likely to play a role in bet hedging and confirm that Tsl1, a trehalose-synthesis regulator, is an important component of this resistance.	Trehalose	105-114	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	97-101
21889199-9	2011	In addition, trehalose cryopreservation provided fast recovery of EGF and TGF-beta1 secretion by KCs after thawing.	Trehalose	13-22	transforming growth factor beta 1	Homo sapiens	74-83
21778669-0	2011	Effect of trehalose coating on basic fibroblast growth factor release from tailor-made bone implants.	Trehalose	10-19	fibroblast growth factor 2	Mus musculus	31-61
21778669-3	2011	In this study, we coated tailor-made bone implants with trehalose to facilitate the release of basic fibroblast growth factor (bFGF).	Trehalose	56-65	fibroblast growth factor 2	Mus musculus	95-125
21778669-3	2011	In this study, we coated tailor-made bone implants with trehalose to facilitate the release of basic fibroblast growth factor (bFGF).	Trehalose	56-65	fibroblast growth factor 2	Mus musculus	127-131
21778669-7	2011	These results suggest that coating artificial bone implants with trehalose could limit the binding of bFGF to calcium phosphate.	Trehalose	65-74	fibroblast growth factor 2	Mus musculus	102-106
21778273-0	2011	Effects of trehalose on VEGF-stimulated angiogenesis and myofibroblast proliferation: implications for glaucoma filtration surgery.	Trehalose	11-20	vascular endothelial growth factor A	Homo sapiens	24-28
21757004-4	2011	A matrix of sucrose or trehalose prevented bacterial aggregation, preserved cell morphology and maintained practically completely the protective lipopolysaccharide (LPS) antigen on the cell surface and its reactivity with specific antibody in vitro.	Trehalose	23-32	toll-like receptor 4	Mus musculus	165-168
21812471-2	2011	Exposure of Tre GOx Pt to PBS containing trehalose (Tr) and subsequent polarization at 0.6 V versus Ag/AgCl yielded after a few minutes well-defined steady-state currents ascribed to the oxidation of hydrogen peroxide generated by the GOx-mediated oxidation of glucose (Gl) produced by the Tre-mediated dissociation of Tr.	Trehalose	41-50	trehalase	Homo sapiens	12-15
21812471-2	2011	Exposure of Tre GOx Pt to PBS containing trehalose (Tr) and subsequent polarization at 0.6 V versus Ag/AgCl yielded after a few minutes well-defined steady-state currents ascribed to the oxidation of hydrogen peroxide generated by the GOx-mediated oxidation of glucose (Gl) produced by the Tre-mediated dissociation of Tr.	Trehalose	41-50	hydroxyacid oxidase 1	Homo sapiens	16-19
21778273-1	2011	PURPOSE: To investigate whether trehalose inhibits VEGF-stimulated or inflammatory angiogenesis and the proliferation of myofibroblasts.	Trehalose	32-41	vascular endothelial growth factor A	Homo sapiens	51-55
21778273-11	2011	The expressions of VEGFR2, phospho-VEGFR2, and vimentin were downregulated by trehalose.	Trehalose	78-87	kinase insert domain receptor	Homo sapiens	19-25
21778273-11	2011	The expressions of VEGFR2, phospho-VEGFR2, and vimentin were downregulated by trehalose.	Trehalose	78-87	kinase insert domain receptor	Homo sapiens	35-41
21778273-11	2011	The expressions of VEGFR2, phospho-VEGFR2, and vimentin were downregulated by trehalose.	Trehalose	78-87	vimentin	Homo sapiens	47-55
21778273-14	2011	CONCLUSIONS: Trehalose prevents angiogenesis by partially downregulating VEGFR2 expression.	Trehalose	13-22	kinase insert domain receptor	Homo sapiens	73-79
21534971-6	2011	bZIP11 induction results in a reprogramming of metabolism and activation of genes involved in the metabolism of trehalose and other minor carbohydrates such as myo-inositol and raffinose.	Trehalose	112-121	G-box binding factor 6	Arabidopsis thaliana	0-6
21753116-5	2011	Three independent transgenic lines were identified with dominant segregation of the trehalose resistance trait that overexpress the bZIP11 (for basic region/leucine zipper motif) transcription factor.	Trehalose	84-93	G-box binding factor 6	Arabidopsis thaliana	132-138
21753116-10	2011	Moreover, the expression of marker genes known to be jointly controlled by SnRK1 activity and bZIP11 was consistent with low SnRK1 or bZIP11 activity in seedlings on trehalose.	Trehalose	166-175	G-box binding factor 6	Arabidopsis thaliana	94-100
21753116-10	2011	Moreover, the expression of marker genes known to be jointly controlled by SnRK1 activity and bZIP11 was consistent with low SnRK1 or bZIP11 activity in seedlings on trehalose.	Trehalose	166-175	G-box binding factor 6	Arabidopsis thaliana	134-140
21534971-0	2011	The sucrose-regulated Arabidopsis transcription factor bZIP11 reprograms metabolism and regulates trehalose metabolism.	Trehalose	98-107	G-box binding factor 6	Arabidopsis thaliana	55-61
21426427-0	2011	TREHALOSE PHOSPHATE SYNTHASE11-dependent trehalose metabolism promotes Arabidopsis thaliana defense against the phloem-feeding insect Myzus persicae.	Trehalose	41-50	trehalose phosphatase/synthase 11	Arabidopsis thaliana	0-30
21380777-1	2011	The effect of overexpression of the trehalose-6-phosphate (T6P) synthase gene (TPS1) on ethanol fermentation of Saccharomyces cerevisiae has been studied at 30 and 38 C. The activity of T6P synthase and the accumulation of trehalose during ethanol fermentation were significantly improved by overexpression of TPS1, and especially at 38 C. Ethanol produced by transformants with and without TPS1 gene overexpression at 38 C was approx.	Trehalose	36-45	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	79-83
21380777-1	2011	The effect of overexpression of the trehalose-6-phosphate (T6P) synthase gene (TPS1) on ethanol fermentation of Saccharomyces cerevisiae has been studied at 30 and 38 C. The activity of T6P synthase and the accumulation of trehalose during ethanol fermentation were significantly improved by overexpression of TPS1, and especially at 38 C. Ethanol produced by transformants with and without TPS1 gene overexpression at 38 C was approx.	Trehalose	36-45	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	310-314
21380777-1	2011	The effect of overexpression of the trehalose-6-phosphate (T6P) synthase gene (TPS1) on ethanol fermentation of Saccharomyces cerevisiae has been studied at 30 and 38 C. The activity of T6P synthase and the accumulation of trehalose during ethanol fermentation were significantly improved by overexpression of TPS1, and especially at 38 C. Ethanol produced by transformants with and without TPS1 gene overexpression at 38 C was approx.	Trehalose	36-45	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	310-314
21426427-2	2011	Here we show that TREHALOSE PHOSPHATE SYNTHASE11 (TPS11) gene-dependent trehalose metabolism regulates Arabidopsis thaliana defense against Myzus persicae (Sulzer), commonly known as the green peach aphid (GPA).	Trehalose	72-81	trehalose phosphatase/synthase 11	Arabidopsis thaliana	18-48
21426427-2	2011	Here we show that TREHALOSE PHOSPHATE SYNTHASE11 (TPS11) gene-dependent trehalose metabolism regulates Arabidopsis thaliana defense against Myzus persicae (Sulzer), commonly known as the green peach aphid (GPA).	Trehalose	72-81	trehalose phosphatase/synthase 11	Arabidopsis thaliana	50-55
21426427-4	2011	Knockout of TPS11 function abolished trehalose increases in GPA-infested leaves of the tps11 mutant plant and attenuated defense against GPA.	Trehalose	37-46	trehalose phosphatase/synthase 11	Arabidopsis thaliana	12-17
21426427-4	2011	Knockout of TPS11 function abolished trehalose increases in GPA-infested leaves of the tps11 mutant plant and attenuated defense against GPA.	Trehalose	37-46	trehalose phosphatase/synthase 11	Arabidopsis thaliana	87-92
21426427-5	2011	Trehalose application restored resistance in the tps11 mutant, confirming that the lack of trehalose accumulation is associated with the inability of the tps11 mutant to control GPA infestation.	Trehalose	0-9	trehalose phosphatase/synthase 11	Arabidopsis thaliana	49-54
21426427-5	2011	Trehalose application restored resistance in the tps11 mutant, confirming that the lack of trehalose accumulation is associated with the inability of the tps11 mutant to control GPA infestation.	Trehalose	91-100	trehalose phosphatase/synthase 11	Arabidopsis thaliana	49-54
21426427-7	2011	Evidence presented here indicates that TPS11-dependent trehalose regulates expression of the PHYTOALEXIN DEFICIENT4 gene, which is a key modulator of defenses against GPA.	Trehalose	55-64	trehalose phosphatase/synthase 11	Arabidopsis thaliana	39-44
21426427-9	2011	Our results provide a framework for the signaling function of TPS11-dependent trehalose in plant stress responses, and also reveal an important contribution of starch in controlling the severity of aphid infestation.	Trehalose	78-87	trehalose phosphatase/synthase 11	Arabidopsis thaliana	62-67
21548571-4	2011	Furthermore, mid-infrared spectra of bovine serum albumin in trehalose aqueous solutions were not significantly modified after the exposures, confirming the hypothesis of the possible bioprotective effectiveness of trehalose against electromagnetic fields.	Trehalose	61-70	albumin	Homo sapiens	50-57
21053069-5	2010	The data obtained clearly demonstrate that in the stress model employed L-carnosine and trehalose down regulate PARP-1 and PARP-2 expression in both cell phenotypes, thus suggesting their possible application in clinical trials.	Trehalose	88-97	poly (ADP-ribose) polymerase 1	Rattus norvegicus	112-118
21492830-3	2011	This paper reports the behaviour of trehalose dihydrate upon milling at cryogenic temperatures as studied by DSC, TGA, XRPD and Raman spectroscopy.	Trehalose	36-55	T-box transcription factor 1	Homo sapiens	114-117
21084378-4	2011	DHR38 null mutants have normal levels of glucose, trehalose (the major circulating form of sugar), and triacylglycerol but display reduced levels of glycogen in the body wall muscles, which constitute the primary storage site for carbohydrates.	Trehalose	50-59	Hormone receptor-like in 38	Drosophila melanogaster	0-5
21345330-9	2011	Furthermore, the levels of storage carbohydrates such as glycogen and trehalose fluctuated in PSK2 mutants with attenuated amplitudes comparable to those in the wild type.	Trehalose	70-79	serine/threonine protein kinase PSK2	Saccharomyces cerevisiae S288C	94-98
21243352-3	2011	According to our results, the tps1 mutant, the only strain tested unable to synthesize trehalose, showed the lowest fermentation yield, indicating that this sugar is important to improve ethanol production.	Trehalose	87-96	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	30-34
21232572-9	2011	In addition, the treatment with trehalose reverted the accumulation, induced by epoxomicin, of polyubiquitinated proteins, total and phosphorylated tau, p-GSK-3, and alpha-synuclein, as well as the alpha-synuclein intracellular aggregates.	Trehalose	32-41	synuclein alpha	Homo sapiens	166-181
21232572-9	2011	In addition, the treatment with trehalose reverted the accumulation, induced by epoxomicin, of polyubiquitinated proteins, total and phosphorylated tau, p-GSK-3, and alpha-synuclein, as well as the alpha-synuclein intracellular aggregates.	Trehalose	32-41	synuclein alpha	Homo sapiens	198-213
21232572-10	2011	The effects of trehalose were not mediated through activation of free radical scavenging compounds, like GSH, or mitochondrial proteins, like DJ1, but trehalose reduced the activation of ERK and chaperone HSP-70 induced by epoxomicin.	Trehalose	151-160	mitogen-activated protein kinase 1	Homo sapiens	187-190
21232572-10	2011	The effects of trehalose were not mediated through activation of free radical scavenging compounds, like GSH, or mitochondrial proteins, like DJ1, but trehalose reduced the activation of ERK and chaperone HSP-70 induced by epoxomicin.	Trehalose	151-160	heat shock protein family A (Hsp70) member 4	Homo sapiens	205-211
20967490-4	2011	RESULTS: The enzymatic activity of beta-galactosidase decreased more slowly in lyophilizates containing trehalose or melibiose at 2:1 excipient/protein weight ratio when compared to those containing sucrose or cellobiose.	Trehalose	104-113	galactosidase beta 1	Homo sapiens	35-53
20920466-0	2011	Effect of trehalose on the interaction of Alzheimer"s Abeta-peptide and anionic lipid monolayers.	Trehalose	10-19	amyloid beta (A4) precursor protein	Mus musculus	54-59
21666345-8	2011	We screened the chemicals that improved these cellular dysfunctions and identified several compounds, including trehalose and Congo red, which could be novel therapeutics for SCA14.	Trehalose	112-121	protein kinase C gamma	Homo sapiens	175-180
21126600-6	2011	However, when trehalose synthesis genes TPS1 and TPS2 were over-expressed in the above recombinant strain AG1A, its high osmotic stress tolerance was not only restored but also improved.	Trehalose	14-23	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	40-44
21126600-6	2011	However, when trehalose synthesis genes TPS1 and TPS2 were over-expressed in the above recombinant strain AG1A, its high osmotic stress tolerance was not only restored but also improved.	Trehalose	14-23	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	49-53
21389736-0	2011	IL-6 mediates 11betaHSD type 2 to effect progression of the mycobacterial cord factor trehalose 6,6"-dimycolate-induced granulomatous response.	Trehalose	86-95	interleukin 6	Mus musculus	0-4
21603604-0	2011	Naturally occurring osmolyte, trehalose induces functional conformation in an intrinsically disordered activation domain of glucocorticoid receptor.	Trehalose	30-39	nuclear receptor subfamily 3 group C member 1	Homo sapiens	124-147
21603604-4	2011	In this study, we tested whether a naturally occurring osmolyte, trehalose can promote functionally ordered conformation in glucocorticoid receptor"s major activation function domain, AF1, which is found to exist as an ID protein, and requires an efficient interaction with coregulatory proteins for optimal activity.	Trehalose	65-74	nuclear receptor subfamily 3 group C member 1	Homo sapiens	124-147
21603604-4	2011	In this study, we tested whether a naturally occurring osmolyte, trehalose can promote functionally ordered conformation in glucocorticoid receptor"s major activation function domain, AF1, which is found to exist as an ID protein, and requires an efficient interaction with coregulatory proteins for optimal activity.	Trehalose	65-74	interferon gamma receptor 2	Homo sapiens	184-187
21603604-5	2011	Our data show that trehalose induces an ordered conformation in AF1 such that its interaction with steroid receptor coactivator-1 (SRC-1), a critical coregulator of glucocorticoid receptor"s activity, is greatly enhanced.	Trehalose	19-28	interferon gamma receptor 2	Homo sapiens	64-67
21603604-5	2011	Our data show that trehalose induces an ordered conformation in AF1 such that its interaction with steroid receptor coactivator-1 (SRC-1), a critical coregulator of glucocorticoid receptor"s activity, is greatly enhanced.	Trehalose	19-28	nuclear receptor coactivator 1	Homo sapiens	99-129
21603604-5	2011	Our data show that trehalose induces an ordered conformation in AF1 such that its interaction with steroid receptor coactivator-1 (SRC-1), a critical coregulator of glucocorticoid receptor"s activity, is greatly enhanced.	Trehalose	19-28	nuclear receptor subfamily 3 group C member 1	Homo sapiens	165-188
21053069-0	2010	Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFgamma-induced oxidative stress.	Trehalose	62-71	poly (ADP-ribose) polymerase 1	Rattus norvegicus	14-20
21053069-0	2010	Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFgamma-induced oxidative stress.	Trehalose	62-71	poly (ADP-ribose) polymerase 2	Rattus norvegicus	25-31
21053069-3	2010	In order to verify the protective action of L: -carnosine and trehalose against NO induced cell death, in the present study we examined their effects on the expression of PARP-1, PARP-2 and iNOS in primary rat astrocyte and oligodendrocyte cells, treated with lipopolysaccharide (LPS) and interferon gamma (INFgamma), through semi-quantitative PCR and western analysis.	Trehalose	62-71	poly (ADP-ribose) polymerase 1	Rattus norvegicus	171-177
21053069-3	2010	In order to verify the protective action of L: -carnosine and trehalose against NO induced cell death, in the present study we examined their effects on the expression of PARP-1, PARP-2 and iNOS in primary rat astrocyte and oligodendrocyte cells, treated with lipopolysaccharide (LPS) and interferon gamma (INFgamma), through semi-quantitative PCR and western analysis.	Trehalose	62-71	poly (ADP-ribose) polymerase 2	Rattus norvegicus	179-185
21053069-3	2010	In order to verify the protective action of L: -carnosine and trehalose against NO induced cell death, in the present study we examined their effects on the expression of PARP-1, PARP-2 and iNOS in primary rat astrocyte and oligodendrocyte cells, treated with lipopolysaccharide (LPS) and interferon gamma (INFgamma), through semi-quantitative PCR and western analysis.	Trehalose	62-71	nitric oxide synthase 2	Rattus norvegicus	190-194
21147367-0	2010	Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance.	Trehalose	0-9	insulin	Homo sapiens	55-62
21147367-2	2010	Given this hypoinsulinemic effect of trehalose, we hypothesized that trehalose suppresses adipocyte hypertrophy by reducing storage of triglyceride and mitigates insulin resistance in mice fed a high-fat diet (HFD).	Trehalose	69-78	insulin	Homo sapiens	15-22
21147367-8	2010	Thus, our data indicate that trehalose prevents adipocyte hypertrophy and mitigates insulin resistance in HFD-fed mice by reducing insulin secretion and down-regulating mRNA expression of MCP-1.	Trehalose	29-38	insulin	Homo sapiens	84-91
21147367-8	2010	Thus, our data indicate that trehalose prevents adipocyte hypertrophy and mitigates insulin resistance in HFD-fed mice by reducing insulin secretion and down-regulating mRNA expression of MCP-1.	Trehalose	29-38	chemokine (C-C motif) ligand 2	Mus musculus	188-193
21147367-9	2010	These findings further suggest that trehalose is a functional saccharide that mitigates insulin resistance.	Trehalose	36-45	insulin	Homo sapiens	88-95
21053069-5	2010	The data obtained clearly demonstrate that in the stress model employed L-carnosine and trehalose down regulate PARP-1 and PARP-2 expression in both cell phenotypes, thus suggesting their possible application in clinical trials.	Trehalose	88-97	poly (ADP-ribose) polymerase 2	Rattus norvegicus	123-129
21037064-1	2010	Trehalase (EC 3.2.1.28) hydrolyzes the main haemolymph sugar of insects, trehalose, into the essential cellular substrate glucose.	Trehalose	73-82	trehalase	Homo sapiens	0-9
20650271-5	2010	Expressions of vimentin and alpha smooth muscle actin (alpha-SMA) changed by trehalose were semiquantitatively measured by Western blot.	Trehalose	77-86	vimentin	Homo sapiens	15-23
20883010-0	2010	Characterization of the rate of thermally-induced aggregation of beta-lactoglobulin and its trehalose mixtures in the glass state.	Trehalose	92-101	beta-lactoglobulin	Bos taurus	65-83
20883010-3	2010	The initial aggregation rate was characterized by the initial rate of tetramer formation (beta-lactoglobulin dimerizes under the elution conditions), which showed Arrhenius temperature dependence with an activation energy of 95 kJ mol(-1) in the temperature range 60-100  C. The trehalose addition slowed the aggregation in a way that depended exponentially on volume fraction, exp(-phi/phi*).	Trehalose	279-288	beta-lactoglobulin	Bos taurus	90-108
20650271-11	2010	Expressions of vimentin and alpha-SMA were reduced by trehalose.	Trehalose	54-63	vimentin	Homo sapiens	15-23
20650271-13	2010	Immunohistochemical studies showed reduced staining of isolectin B4, vimentin and alpha-SMA in conjunctival wounds treated by topical trehalose.	Trehalose	134-143	vimentin	Homo sapiens	69-77
21535506-3	2010	The inactivation rate constant value of one of the mutants was comparable with that of a previously reported highly barosensitive strain, which was generated by deletion of hsp104 in a trehalose deficient strain.	Trehalose	185-194	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	173-179
20705605-0	2010	Effect of trehalose on the properties of mutant {gamma}PKC, which causes spinocerebellar ataxia type 14, in neuronal cell lines and cultured Purkinje cells.	Trehalose	10-19	protein kinase C gamma	Homo sapiens	55-58
20543015-2	2010	One of the Gr genes, Gr5a, encodes a receptor for trehalose that is expressed in a subset of GRNs.	Trehalose	50-59	Gustatory receptor 5a	Drosophila melanogaster	21-25
20543015-3	2010	Although a role for the G protein, Gsalpha, has been shown in Gr5a-expressing taste neurons, there is the residual responses to trehalose in Gsalpha mutants which could suggest additional transduction mechanisms.	Trehalose	128-137	G protein alpha s subunit	Drosophila melanogaster	141-148
20543015-4	2010	Expression and genetic analysis of the heterotrimeric G-protein subunit, Gq, shown here suggest involvement of this Galpha subunit in trehalose perception in Drosophila.	Trehalose	134-143	G protein alpha q subunit	Drosophila melanogaster	116-122
20477758-8	2010	On the other hand, the life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants.	Trehalose	53-62	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	120-125
20546895-0	2010	Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation.	Trehalose	0-9	microtubule associated protein tau	Homo sapiens	39-42
20546895-0	2010	Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation.	Trehalose	0-9	microtubule associated protein tau	Homo sapiens	71-74
20546895-7	2010	In this work, we tested if 1% trehalose in the drinking water reverts the PK(-/-)/Tau(VLW) phenotype.	Trehalose	30-39	microtubule associated protein tau	Homo sapiens	82-85
20546895-8	2010	The treatment with trehalose of 3-month-old PK(-/-)/Tau(VLW) mice for 2.5 months reverted the dropout of dopamine neurons, which takes place in the ventral midbrain of vehicle treated PK(-/-)/Tau(VLW) and the reduced dopamine-related proteins levels in the midbrain and striatum.	Trehalose	19-28	microtubule associated protein tau	Homo sapiens	52-55
20546895-8	2010	The treatment with trehalose of 3-month-old PK(-/-)/Tau(VLW) mice for 2.5 months reverted the dropout of dopamine neurons, which takes place in the ventral midbrain of vehicle treated PK(-/-)/Tau(VLW) and the reduced dopamine-related proteins levels in the midbrain and striatum.	Trehalose	19-28	microtubule associated protein tau	Homo sapiens	192-195
20546895-11	2010	The treatment with trehalose for 4 months of 3-month-old PK(-/-)/Tau(VLW) mice maintained the amelioration of the tau pathology and astrogliosis but failed to revert DA-related pathology in the striatum.	Trehalose	19-28	microtubule associated protein tau	Homo sapiens	65-68
20546895-11	2010	The treatment with trehalose for 4 months of 3-month-old PK(-/-)/Tau(VLW) mice maintained the amelioration of the tau pathology and astrogliosis but failed to revert DA-related pathology in the striatum.	Trehalose	19-28	microtubule associated protein tau	Homo sapiens	114-117
20546895-12	2010	Furthermore, the 3-week treatment with trehalose of 14-month-old PK(-/-)/Tau(VLW) mice, at the limit of their life expectancy, improved the motor behavior and anxiety of these animals, and reduced their levels of phosphorylated tau and the number of murine beta-amyloid plaques.	Trehalose	39-48	microtubule associated protein tau	Homo sapiens	73-76
20546895-12	2010	Furthermore, the 3-week treatment with trehalose of 14-month-old PK(-/-)/Tau(VLW) mice, at the limit of their life expectancy, improved the motor behavior and anxiety of these animals, and reduced their levels of phosphorylated tau and the number of murine beta-amyloid plaques.	Trehalose	39-48	microtubule associated protein tau	Homo sapiens	228-231
20477758-9	2010	RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span.	Trehalose	46-55	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1	Caenorhabditis elegans	75-107
20477758-9	2010	RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span.	Trehalose	46-55	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1	Caenorhabditis elegans	109-114
20477758-9	2010	RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span.	Trehalose	46-55	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2	Caenorhabditis elegans	120-125
20477758-9	2010	RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span.	Trehalose	46-55	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	165-170
20477758-9	2010	RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span.	Trehalose	46-55	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	194-199
20502833-3	2010	The chemical shift perturbations of nuclei in the protein"s backbone caused by the binding of the Glc(2)Man(2)-fragment to malectin suggest a binding mode like the known ligand nigerose.	Trehalose	98-104	malectin	Homo sapiens	123-131
20363292-5	2010	Aggregate formation and mutant SOD1 detergent insolubility were significantly decreased in the presence of millimolar concentrations of trehalose possibly due to its capacity to induce autophagy or to its properties as chemical chaperone.	Trehalose	136-145	superoxide dismutase 1, soluble	Mus musculus	31-35
20493190-3	2010	In this study, we also generated a dIde knockout mutant (dIde(KO)) by gene targeting, and found that loss of IDE increases the content of the major insect blood sugar, trehalose, thus suggesting a conserved role of IDE in sugar metabolism.	Trehalose	168-177	Insulin degrading metalloproteinase	Drosophila melanogaster	109-112
20420874-3	2010	Furthermore, flies which expressed the mu opioid receptor in the AKH or corazonin endocrine cells increased rather than decreased trehalose levels and this was independent of opioid agonists.	Trehalose	130-139	Adipokinetic hormone	Drosophila melanogaster	65-68
19949793-5	2010	In the 62 degrees C condition, the PM2 protein (1:5 mass ratio to LDH) effectively prevented the LDH thermo-denaturation by acting synergistically with trehalose (62.5 microg/ml), although the PM2 protein alone at this concentration showed little protective effect on LDH activity.	Trehalose	152-161	maturation polypeptide	Glycine max	35-38
20148975-5	2010	Trehalose inhibited the isolated glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and hexokinase (HXK), but not aldolase (ALD) nor phosphoglycerate kinase (PGK).	Trehalose	0-9	hexokinase	Saccharomyces cerevisiae S288C	86-96
20148975-5	2010	Trehalose inhibited the isolated glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and hexokinase (HXK), but not aldolase (ALD) nor phosphoglycerate kinase (PGK).	Trehalose	0-9	hexokinase	Saccharomyces cerevisiae S288C	98-101
20148975-5	2010	Trehalose inhibited the isolated glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and hexokinase (HXK), but not aldolase (ALD) nor phosphoglycerate kinase (PGK).	Trehalose	0-9	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	156-159
20081087-7	2010	Compared with the other groups, CAT was greater with the supplementation of trehalose at 100 and 200 mM (P &lt; 0.05).	Trehalose	76-85	catalase	Bos taurus	32-35
20159575-3	2010	The contents of trehalose constitutively accumulated in the TPS1- and TPS2-overexpressing triple deletion strains were higher than that in the original triple deletion strain.	Trehalose	16-25	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	60-64
20159575-3	2010	The contents of trehalose constitutively accumulated in the TPS1- and TPS2-overexpressing triple deletion strains were higher than that in the original triple deletion strain.	Trehalose	16-25	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	70-74
20159575-4	2010	High trehalose accumulation and growth activity were observed in the TPS2-overexpressing triple deletion strain after ethanol stress induction.	Trehalose	5-14	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	69-73
20171005-0	2010	Anti-aggregation properties of trehalose on heat-induced secondary structure and conformation changes of bovine serum albumin.	Trehalose	31-40	albumin	Homo sapiens	112-125
20171005-1	2010	During our experimental work, aggregation of bovine serum albumin was obtained incubating the protein solution at 60 degrees C to investigate temperature-induced secondary structure, conformation changes and anti-aggregative activity of trehalose.	Trehalose	237-246	albumin	Homo sapiens	52-65
19944744-4	2010	In this study, we demonstrated that the protein levels of TDP-43 and TDP-25 were increased in cells treated with a proteasome inhibitor, MG132, or an autophagy inhibitor, 3-MA, whereas, they were decreased in cells treated with an enhancer of autophagy, trehalose.	Trehalose	254-263	TAR DNA binding protein	Homo sapiens	58-64
19664296-7	2009	Differences in peak insulin response and DeltaAUC were observed with trehalose when compared with glucose during the morning and afternoon.	Trehalose	69-78	insulin	Homo sapiens	20-27
19542522-6	2009	Here we demonstrate that Gtb1p also determines the rate of Glc2 trimming.	Trehalose	59-63	Gtb1p	Saccharomyces cerevisiae S288C	25-30
19837796-3	2009	Genes coding for three possible trehalose synthesis pathways are present in the genome of S. meliloti 1021: OtsA, TreYZ, and TreS.	Trehalose	32-41	alpha,alpha-trehalose-phosphate synthase (UDP-forming)	Sinorhizobium meliloti 1021	108-112
19837796-4	2009	Among these, OtsA has a major role in trehalose accumulation under all of the conditions tested and is the main system involved in osmoadaptation.	Trehalose	38-47	alpha,alpha-trehalose-phosphate synthase (UDP-forming)	Sinorhizobium meliloti 1021	13-17
20059115-1	2009	The low-frequency (omega&lt;400 cm(-1)) vibrational properties of lysozyme in aqueous solutions of three well-known protecting sugars, namely, trehalose, maltose, and sucrose, have been investigated by means of complementary Raman scattering experiments and molecular dynamics simulations.	Trehalose	143-152	lysozyme	Homo sapiens	66-74
19734328-8	2009	While transcriptome analysis of wild-type and msn2Delta msn4Delta strains confirmed that transcriptional upregulation of glycogen and trehalose biosynthesis genes is mediated by Msn2p/Msn4p, transcriptional regulation could not quantitatively account for the drastic changes in storage carbohydrate accumulation.	Trehalose	134-143	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	178-183
19734328-8	2009	While transcriptome analysis of wild-type and msn2Delta msn4Delta strains confirmed that transcriptional upregulation of glycogen and trehalose biosynthesis genes is mediated by Msn2p/Msn4p, transcriptional regulation could not quantitatively account for the drastic changes in storage carbohydrate accumulation.	Trehalose	134-143	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	184-189
19897915-0	2009	Catalytic reaction mechanism based on alpha-secondary deuterium isotope effects in hydrolysis of trehalose by European honeybee trehalase.	Trehalose	97-106	trehalase	Apis mellifera	128-137
19897915-1	2009	Trehalase, an anomer-inverting glycosidase, hydrolyzes only alpha,alpha-trehalose in natural substrates to release equimolecular beta-glucose and alpha-glucose.	Trehalose	60-81	trehalase	Apis mellifera	0-9
19555421-10	2009	Further studies revealed that trehalose could prevent the apoptosis of refrigerated PLTs, which was determined by the phosphatidylserine exposure, caspase-3 activities, mitochondrial transmembrane potentials, and expression of Bcl-XL and Bax.	Trehalose	30-39	caspase 3	Homo sapiens	147-156
19620241-0	2009	The trehalose pathway regulates mitochondrial respiratory chain content through hexokinase 2 and cAMP in Saccharomyces cerevisiae.	Trehalose	4-13	hexokinase 2	Saccharomyces cerevisiae S288C	80-92
19620241-1	2009	In yeast, trehalose is synthesized by a multimeric enzymatic complex: TPS1 encodes trehalose 6-phosphate synthase, which belongs to a complex that is composed of at least three other subunits, including trehalose 6-phosphate phosphatase Tps2 and the redundant regulatory subunits Tps3 and Tsl1.	Trehalose	10-19	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	70-74
19620241-1	2009	In yeast, trehalose is synthesized by a multimeric enzymatic complex: TPS1 encodes trehalose 6-phosphate synthase, which belongs to a complex that is composed of at least three other subunits, including trehalose 6-phosphate phosphatase Tps2 and the redundant regulatory subunits Tps3 and Tsl1.	Trehalose	10-19	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	237-241
19620241-1	2009	In yeast, trehalose is synthesized by a multimeric enzymatic complex: TPS1 encodes trehalose 6-phosphate synthase, which belongs to a complex that is composed of at least three other subunits, including trehalose 6-phosphate phosphatase Tps2 and the redundant regulatory subunits Tps3 and Tsl1.	Trehalose	10-19	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	280-284
19620241-1	2009	In yeast, trehalose is synthesized by a multimeric enzymatic complex: TPS1 encodes trehalose 6-phosphate synthase, which belongs to a complex that is composed of at least three other subunits, including trehalose 6-phosphate phosphatase Tps2 and the redundant regulatory subunits Tps3 and Tsl1.	Trehalose	10-19	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	289-293
19620241-4	2009	We show that the different mutants of the trehalose synthesis pathway (tps1Delta, tps2Delta, and tps1,2Delta) exhibit modulation in the amount of respiratory chains, in terms of cytochrome content and maximal respiratory activity.	Trehalose	42-51	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	97-108
19703229-5	2009	Finally, the physiological significance of the cell-surface localization of Ath1 was established by showing that fusion of the signal peptide of invertase to N-terminal truncated Ath1 allowed the ath1Delta mutant to grow on trehalose, whereas the signal sequence of the vacuolar-targeted Pep4 constrained Ath1 in the vacuole and prevented growth of this mutant on trehalose.	Trehalose	364-373	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	179-183
19703229-5	2009	Finally, the physiological significance of the cell-surface localization of Ath1 was established by showing that fusion of the signal peptide of invertase to N-terminal truncated Ath1 allowed the ath1Delta mutant to grow on trehalose, whereas the signal sequence of the vacuolar-targeted Pep4 constrained Ath1 in the vacuole and prevented growth of this mutant on trehalose.	Trehalose	364-373	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	179-183
19703407-0	2009	Kinetics of the thermal inactivation and aggregate formation of rabbit muscle pyruvate kinase in the presence of trehalose.	Trehalose	113-122	pyruvate kinase PKLR	Oryctolagus cuniculus	78-93
19703407-2	2009	Because dimethylsulfoxide is known to perturb structure and function of many proteins, we have explored the effect of trehalose on the kinetics of thermal inactivation and stability of pyruvate kinase; this is because trehalose, in contrast to dimethyl sulfoxide, is totally excluded from the hydration shell of proteins.	Trehalose	118-127	pyruvate kinase PKLR	Oryctolagus cuniculus	185-200
19703407-2	2009	Because dimethylsulfoxide is known to perturb structure and function of many proteins, we have explored the effect of trehalose on the kinetics of thermal inactivation and stability of pyruvate kinase; this is because trehalose, in contrast to dimethyl sulfoxide, is totally excluded from the hydration shell of proteins.	Trehalose	218-227	pyruvate kinase PKLR	Oryctolagus cuniculus	185-200
19703407-3	2009	The results show that 600 mM trehalose inhibits the activity of pyruvate kinase by about 20% at 25 degrees C, however, trehalose protects pyruvate kinase from thermal inactivation at 60 degrees C, increases the Tm(app) of unfolding by 7.2 degrees C, induces a more compact state, and stabilizes its tetrameric structure.	Trehalose	29-38	pyruvate kinase PKLR	Oryctolagus cuniculus	64-79
19703407-3	2009	The results show that 600 mM trehalose inhibits the activity of pyruvate kinase by about 20% at 25 degrees C, however, trehalose protects pyruvate kinase from thermal inactivation at 60 degrees C, increases the Tm(app) of unfolding by 7.2 degrees C, induces a more compact state, and stabilizes its tetrameric structure.	Trehalose	119-128	pyruvate kinase PKLR	Oryctolagus cuniculus	64-79
19703407-3	2009	The results show that 600 mM trehalose inhibits the activity of pyruvate kinase by about 20% at 25 degrees C, however, trehalose protects pyruvate kinase from thermal inactivation at 60 degrees C, increases the Tm(app) of unfolding by 7.2 degrees C, induces a more compact state, and stabilizes its tetrameric structure.	Trehalose	119-128	pyruvate kinase PKLR	Oryctolagus cuniculus	138-153
19703229-1	2009	Previous studies in the yeast Saccharomyces cerevisiae have proposed a vacuolar localization for Ath1, which is difficult to reconcile with its ability to hydrolyze exogenous trehalose.	Trehalose	175-184	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	97-101
19703229-5	2009	Finally, the physiological significance of the cell-surface localization of Ath1 was established by showing that fusion of the signal peptide of invertase to N-terminal truncated Ath1 allowed the ath1Delta mutant to grow on trehalose, whereas the signal sequence of the vacuolar-targeted Pep4 constrained Ath1 in the vacuole and prevented growth of this mutant on trehalose.	Trehalose	224-233	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	76-80
19703229-5	2009	Finally, the physiological significance of the cell-surface localization of Ath1 was established by showing that fusion of the signal peptide of invertase to N-terminal truncated Ath1 allowed the ath1Delta mutant to grow on trehalose, whereas the signal sequence of the vacuolar-targeted Pep4 constrained Ath1 in the vacuole and prevented growth of this mutant on trehalose.	Trehalose	224-233	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	179-183
19703229-5	2009	Finally, the physiological significance of the cell-surface localization of Ath1 was established by showing that fusion of the signal peptide of invertase to N-terminal truncated Ath1 allowed the ath1Delta mutant to grow on trehalose, whereas the signal sequence of the vacuolar-targeted Pep4 constrained Ath1 in the vacuole and prevented growth of this mutant on trehalose.	Trehalose	224-233	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	179-183
19703229-5	2009	Finally, the physiological significance of the cell-surface localization of Ath1 was established by showing that fusion of the signal peptide of invertase to N-terminal truncated Ath1 allowed the ath1Delta mutant to grow on trehalose, whereas the signal sequence of the vacuolar-targeted Pep4 constrained Ath1 in the vacuole and prevented growth of this mutant on trehalose.	Trehalose	364-373	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	76-80
19442960-1	2009	This work presents an analysis of near environment of myoglobin (Mb) in different aqueous solutions (in the presence of NaCl, sucrose, trehalose, urea, and glycerol) using the coupled water fractions measured using a quartz crystal microbalance (QCM).	Trehalose	135-144	myoglobin	Homo sapiens	54-63
19555421-10	2009	Further studies revealed that trehalose could prevent the apoptosis of refrigerated PLTs, which was determined by the phosphatidylserine exposure, caspase-3 activities, mitochondrial transmembrane potentials, and expression of Bcl-XL and Bax.	Trehalose	30-39	BCL2 like 1	Homo sapiens	227-233
19442960-1	2009	This work presents an analysis of near environment of myoglobin (Mb) in different aqueous solutions (in the presence of NaCl, sucrose, trehalose, urea, and glycerol) using the coupled water fractions measured using a quartz crystal microbalance (QCM).	Trehalose	135-144	myoglobin	Homo sapiens	65-67
19555421-10	2009	Further studies revealed that trehalose could prevent the apoptosis of refrigerated PLTs, which was determined by the phosphatidylserine exposure, caspase-3 activities, mitochondrial transmembrane potentials, and expression of Bcl-XL and Bax.	Trehalose	30-39	BCL2 associated X, apoptosis regulator	Homo sapiens	238-241
19632110-2	2009	Synthesis of the two diastereomeric isomers of the molecule followed by chiral resolution of each enantiomer revealed the (2R,3S)-isomer to be a potent norepinephrine reuptake inhibitor (IC(50)=28 nM) with excellent selectivity over the dopamine transporter and 13-fold selectivity over the serotonin transporter.	Trehalose	122-129	solute carrier family 6 member 3	Homo sapiens	237-257
19640707-0	2009	Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.	Trehalose	24-31	solute carrier family 6 member 2	Homo sapiens	82-107
19840487-7	2009	The combination of DMSO and trehalose revealed the protective effect on the external morphology and internal structure of platelets to be close to the normal homeostasis, and ensured an ideal recovery rate of the cryopreserved platelets and higher expression levels of CD41, CD42b, CD61 and CD62p in the same time.	Trehalose	28-37	integrin subunit alpha 2b	Homo sapiens	269-273
19840487-7	2009	The combination of DMSO and trehalose revealed the protective effect on the external morphology and internal structure of platelets to be close to the normal homeostasis, and ensured an ideal recovery rate of the cryopreserved platelets and higher expression levels of CD41, CD42b, CD61 and CD62p in the same time.	Trehalose	28-37	glycoprotein Ib platelet subunit alpha	Homo sapiens	275-280
19840487-7	2009	The combination of DMSO and trehalose revealed the protective effect on the external morphology and internal structure of platelets to be close to the normal homeostasis, and ensured an ideal recovery rate of the cryopreserved platelets and higher expression levels of CD41, CD42b, CD61 and CD62p in the same time.	Trehalose	28-37	integrin subunit beta 3	Homo sapiens	282-286
19840487-7	2009	The combination of DMSO and trehalose revealed the protective effect on the external morphology and internal structure of platelets to be close to the normal homeostasis, and ensured an ideal recovery rate of the cryopreserved platelets and higher expression levels of CD41, CD42b, CD61 and CD62p in the same time.	Trehalose	28-37	selectin P	Homo sapiens	291-296
19637920-5	2009	In this article, we tested the influence of trehalose, sucrose and trimethylamine-N-oxide (TMAO) on Abeta aggregation and fluorescent dye leakage induced by Abeta aggregates from liposomes.	Trehalose	44-53	amyloid beta precursor protein	Homo sapiens	100-105
19632110-2	2009	Synthesis of the two diastereomeric isomers of the molecule followed by chiral resolution of each enantiomer revealed the (2R,3S)-isomer to be a potent norepinephrine reuptake inhibitor (IC(50)=28 nM) with excellent selectivity over the dopamine transporter and 13-fold selectivity over the serotonin transporter.	Trehalose	122-129	solute carrier family 6 member 4	Homo sapiens	291-312
19520725-0	2009	The three trehalases Nth1p, Nth2p and Ath1p participate in the mobilization of intracellular trehalose required for recovery from saline stress in Saccharomyces cerevisiae.	Trehalose	93-102	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	21-26
19664552-8	2009	Expression levels of TPS1 and TSL1, which are responsible for trehalose biosynthesis, were higher in YFY strains relative to W303-1A, resulting in high levels of intracellular trehalose in YFY strains.	Trehalose	62-71	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	21-25
19664552-8	2009	Expression levels of TPS1 and TSL1, which are responsible for trehalose biosynthesis, were higher in YFY strains relative to W303-1A, resulting in high levels of intracellular trehalose in YFY strains.	Trehalose	62-71	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	30-34
19664552-8	2009	Expression levels of TPS1 and TSL1, which are responsible for trehalose biosynthesis, were higher in YFY strains relative to W303-1A, resulting in high levels of intracellular trehalose in YFY strains.	Trehalose	176-185	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	21-25
19664552-8	2009	Expression levels of TPS1 and TSL1, which are responsible for trehalose biosynthesis, were higher in YFY strains relative to W303-1A, resulting in high levels of intracellular trehalose in YFY strains.	Trehalose	176-185	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	30-34
19520725-0	2009	The three trehalases Nth1p, Nth2p and Ath1p participate in the mobilization of intracellular trehalose required for recovery from saline stress in Saccharomyces cerevisiae.	Trehalose	93-102	alpha,alpha-trehalase NTH2	Saccharomyces cerevisiae S288C	28-33
19520725-0	2009	The three trehalases Nth1p, Nth2p and Ath1p participate in the mobilization of intracellular trehalose required for recovery from saline stress in Saccharomyces cerevisiae.	Trehalose	93-102	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	38-43
19505677-0	2009	Trehalose inhibits inflammatory cytokine production by protecting IkappaB-alpha reduction in mouse peritoneal macrophages.	Trehalose	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	66-79
19505677-7	2009	RESULTS: Treatment with trehalose suppressed LPS-induced IL-1beta and TNF-alpha production and downregulated transcription of these cytokines.	Trehalose	24-33	interleukin 1 beta	Mus musculus	57-65
19505677-7	2009	RESULTS: Treatment with trehalose suppressed LPS-induced IL-1beta and TNF-alpha production and downregulated transcription of these cytokines.	Trehalose	24-33	tumor necrosis factor	Mus musculus	70-79
19505677-8	2009	Furthermore, trehalose inhibited LPS-induced reduction of IkappaB-alpha.	Trehalose	13-22	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	58-71
19505677-10	2009	CONCLUSION: These results may suggest that trehalose inhibits LPS-induced production of IL-1beta and TNF-alpha in mouse peritoneal macrophages by inhibiting degradation of IkappaB-alphavia the trehalose receptor T1R3.	Trehalose	43-52	interleukin 1 beta	Mus musculus	88-96
19505677-10	2009	CONCLUSION: These results may suggest that trehalose inhibits LPS-induced production of IL-1beta and TNF-alpha in mouse peritoneal macrophages by inhibiting degradation of IkappaB-alphavia the trehalose receptor T1R3.	Trehalose	43-52	tumor necrosis factor	Mus musculus	101-110
19505677-10	2009	CONCLUSION: These results may suggest that trehalose inhibits LPS-induced production of IL-1beta and TNF-alpha in mouse peritoneal macrophages by inhibiting degradation of IkappaB-alphavia the trehalose receptor T1R3.	Trehalose	43-52	taste receptor, type 1, member 3	Mus musculus	212-216
19409412-1	2009	In the present article the influence of salts and additives, such as trehalose, NaCl, ornithine, sodium phosphate and ammonium sulphate, on ornithine carbamoyltransferase (OCTase) is investigated in order to study the OCTase stabilization process as a function of solutes and to point out the fundamental role played by an enhancement of hydrophobic interactions.	Trehalose	69-78	ornithine transcarbamylase	Homo sapiens	140-170
19409412-1	2009	In the present article the influence of salts and additives, such as trehalose, NaCl, ornithine, sodium phosphate and ammonium sulphate, on ornithine carbamoyltransferase (OCTase) is investigated in order to study the OCTase stabilization process as a function of solutes and to point out the fundamental role played by an enhancement of hydrophobic interactions.	Trehalose	69-78	ornithine transcarbamylase	Homo sapiens	172-178
19521507-0	2009	MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis.	Trehalose	86-95	macrophage receptor with collagenous structure	Mus musculus	0-5
19344332-2	2009	In Arabidopsis, 21 putative trehalose biosynthesis genes are classified in three subfamilies based on their similarity with yeast TPS1 (encoding a trehalose-6-phosphate synthase, TPS) or TPS2 (encoding a trehalose-6-phosphate phosphatase, TPP).	Trehalose	28-37	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	130-134
19344332-2	2009	In Arabidopsis, 21 putative trehalose biosynthesis genes are classified in three subfamilies based on their similarity with yeast TPS1 (encoding a trehalose-6-phosphate synthase, TPS) or TPS2 (encoding a trehalose-6-phosphate phosphatase, TPP).	Trehalose	28-37	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	187-191
19344332-2	2009	In Arabidopsis, 21 putative trehalose biosynthesis genes are classified in three subfamilies based on their similarity with yeast TPS1 (encoding a trehalose-6-phosphate synthase, TPS) or TPS2 (encoding a trehalose-6-phosphate phosphatase, TPP).	Trehalose	28-37	thylakoid processing peptide	Arabidopsis thaliana	239-242
19232773-2	2009	For this purpose, we used validamycin A, a potent trehalase inhibitor, in order to induce trehalose accumulation.	Trehalose	90-99	probable trehalase	Medicago truncatula	50-59
19232773-3	2009	Validamycin A induced an increase of trehalose concentration in root nodules of M. truncatula by inhibiting trehalase activity; no effect on trehalose concentration was observed in roots and leaves.	Trehalose	37-46	probable trehalase	Medicago truncatula	108-117
19306919-1	2009	The aim of this review is to highlight the role of myo-inositol phosphate synthase (MIPS), which catalyses the first step in inositol biosynthesis and of sucrose synthase (Sus), an enzyme involved in UDP-glucose formation, the principal nucleoside diphosphate in the sucrose cleavage reaction and in trehalose biosynthesis.	Trehalose	300-309	myo-inositol-3-phosphate synthase	Glycine max	51-82
19306919-1	2009	The aim of this review is to highlight the role of myo-inositol phosphate synthase (MIPS), which catalyses the first step in inositol biosynthesis and of sucrose synthase (Sus), an enzyme involved in UDP-glucose formation, the principal nucleoside diphosphate in the sucrose cleavage reaction and in trehalose biosynthesis.	Trehalose	300-309	myo-inositol-3-phosphate synthase	Glycine max	84-88
19306919-1	2009	The aim of this review is to highlight the role of myo-inositol phosphate synthase (MIPS), which catalyses the first step in inositol biosynthesis and of sucrose synthase (Sus), an enzyme involved in UDP-glucose formation, the principal nucleoside diphosphate in the sucrose cleavage reaction and in trehalose biosynthesis.	Trehalose	300-309	sucrose synthase	Glycine max	154-170
19306919-1	2009	The aim of this review is to highlight the role of myo-inositol phosphate synthase (MIPS), which catalyses the first step in inositol biosynthesis and of sucrose synthase (Sus), an enzyme involved in UDP-glucose formation, the principal nucleoside diphosphate in the sucrose cleavage reaction and in trehalose biosynthesis.	Trehalose	300-309	sucrose synthase	Glycine max	172-175
19383678-5	2009	Because the mutant strain displayed a higher intracellular trehalose concentration than the wild-type, which could mask the effect of manipulating HSP12, we overexpressed the HSP12 gene in a trehalose-6-phosphate synthase (TPS1) null mutant.	Trehalose	59-68	lipid-binding protein HSP12	Saccharomyces cerevisiae S288C	175-180
19383678-6	2009	The tps1Delta strain overexpressing HSP12 showed an increase in resistance to freezing storage, indicating that Hsp12p plays a role in freezing tolerance in a way that seems to be interchangeable with trehalose.	Trehalose	201-210	lipid-binding protein HSP12	Saccharomyces cerevisiae S288C	36-41
19383678-7	2009	In addition, we show that overexpression of HSP12 in this tps1Delta strain also increased resistance to heat shock and that absence of HSP12 compromises the ability of yeast cells to accumulate high levels of trehalose in response to a mild heat stress.	Trehalose	209-218	lipid-binding protein HSP12	Saccharomyces cerevisiae S288C	44-49
19383678-7	2009	In addition, we show that overexpression of HSP12 in this tps1Delta strain also increased resistance to heat shock and that absence of HSP12 compromises the ability of yeast cells to accumulate high levels of trehalose in response to a mild heat stress.	Trehalose	209-218	lipid-binding protein HSP12	Saccharomyces cerevisiae S288C	135-140
19385694-0	2009	Thermostabilization mechanism of bovine serum albumin by trehalose.	Trehalose	57-66	albumin	Homo sapiens	40-53
19594018-9	2009	CONCLUSION: Trehalose/DMSO is better than traditional cryoprotectant DMSO/propanediol in protecting Dsg 1 of human skin.	Trehalose	12-21	desmoglein 1	Homo sapiens	100-105
19336219-5	2009	In turn, the cell wall-linked trehalase (Atc1p) showed elevated activity in resting cells or in cultures growing on trehalose or glycerol.	Trehalose	116-125	Atc1p	Saccharomyces cerevisiae S288C	41-46
19182537-4	2009	Here, we demonstrate that trehalose can significantly reduce PrP(Sc) in a dose- and time-dependent manner while at the same time it induces autophagy in persistently prion-infected neuronal cells.	Trehalose	26-35	prion protein	Mus musculus	61-64
19182537-9	2009	Preliminary in vivo studies with trehalose in intraperitoneally prion-infected mice did not result in prolongation of incubation times, but demonstrated delayed appearance of PrP(Sc) in the spleen.	Trehalose	33-42	prion protein	Mus musculus	175-178
19175415-5	2009	The results also show that stress-responsive genes (HSP12, SSA3, PAU5, SOD1, SOD2, CTA1 and CTT1) were induced during the process, together with the accumulation of trehalose.	Trehalose	165-174	lipid-binding protein HSP12	Saccharomyces cerevisiae S288C	52-57
19135990-9	2009	The addition of trehalose is correlated with high osmotic pressure, which had minor effects during incubation at 4 degrees C, but seemed to have exacerbated the severity of cellular injury at 37 degrees C, as measured by higher levels of hemolysis, methemoglobin and lipid peroxidation.	Trehalose	16-25	hemoglobin subunit gamma 2	Homo sapiens	249-262
18988262-5	2009	Interestingly, we report here that CYP2D6 colyophilized with trehalose and suspended in n-decane shows higher activity than in aqueous buffer.	Trehalose	61-70	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	35-41
19175415-5	2009	The results also show that stress-responsive genes (HSP12, SSA3, PAU5, SOD1, SOD2, CTA1 and CTT1) were induced during the process, together with the accumulation of trehalose.	Trehalose	165-174	Hsp70 family ATPase SSA3	Saccharomyces cerevisiae S288C	59-63
19175415-5	2009	The results also show that stress-responsive genes (HSP12, SSA3, PAU5, SOD1, SOD2, CTA1 and CTT1) were induced during the process, together with the accumulation of trehalose.	Trehalose	165-174	seripauperin PAU5	Saccharomyces cerevisiae S288C	65-69
19004876-4	2009	The activity of trehalose-6-phosphate synthase (TPS) during H. armigera larval-pupal development is significantly higher in diapause-type individuals and is closely correlated with the changes in the trehalose content.	Trehalose	16-25	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	48-51
19175415-5	2009	The results also show that stress-responsive genes (HSP12, SSA3, PAU5, SOD1, SOD2, CTA1 and CTT1) were induced during the process, together with the accumulation of trehalose.	Trehalose	165-174	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	71-75
19004876-9	2009	The Har-TPS mRNA was detected at high levels in the late stage of sixth larval instar and the early middle stage of diapause-destined pupae, which are most likely to respond the changes in TPS activity and trehalose in the hemolymph.	Trehalose	206-215	narrow abdomen	Drosophila melanogaster	4-7
19004876-9	2009	The Har-TPS mRNA was detected at high levels in the late stage of sixth larval instar and the early middle stage of diapause-destined pupae, which are most likely to respond the changes in TPS activity and trehalose in the hemolymph.	Trehalose	206-215	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	8-11
19175415-5	2009	The results also show that stress-responsive genes (HSP12, SSA3, PAU5, SOD1, SOD2, CTA1 and CTT1) were induced during the process, together with the accumulation of trehalose.	Trehalose	165-174	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	77-81
19175415-5	2009	The results also show that stress-responsive genes (HSP12, SSA3, PAU5, SOD1, SOD2, CTA1 and CTT1) were induced during the process, together with the accumulation of trehalose.	Trehalose	165-174	catalase T	Saccharomyces cerevisiae S288C	92-96
22303248-17	2009	This supports a function for T6P as a sugar signaling molecule integrating metabolism and development in plants in relation to carbon supply.Genetic engineering of Arabidopsis as well as tobacco, potato and rice with TPS or TPS/TPP protein fusions reveals that trehalose metabolism also mediates multiple abiotic stress tolerances.	Trehalose	261-270	trehalose-6-phosphate synthase	Arabidopsis thaliana	217-220
19126402-2	2009	ATH1, and NTH1 hydrolyze trehalose to glucose to provide energy and assist in recovery from stress.	Trehalose	25-34	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	0-4
19126402-2	2009	ATH1, and NTH1 hydrolyze trehalose to glucose to provide energy and assist in recovery from stress.	Trehalose	25-34	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	10-14
19126402-3	2009	Human trehalase (TREH) is expressed in the intestine and kidney and probably hydrolyzes ingested trehalose in the intestine and acts as marker of renal tubular damage in kidney.	Trehalose	97-106	trehalase	Homo sapiens	6-15
19126402-3	2009	Human trehalase (TREH) is expressed in the intestine and kidney and probably hydrolyzes ingested trehalose in the intestine and acts as marker of renal tubular damage in kidney.	Trehalose	97-106	trehalase	Homo sapiens	17-21
18983838-5	2009	The ABCB1 purification procedure was optimised to allow successful freeze drying by substitution of glycerol with the disaccharides trehalose or maltose.	Trehalose	132-141	ATP binding cassette subfamily B member 1	Homo sapiens	4-9
18983838-7	2009	However, during storage trehalose preserved ATPase activity for several months regardless of the temperature (e.g. 60% retention at 150 days), whereas ATPase activity in maltose purified P-gp was affected by both storage time and temperature.	Trehalose	24-33	dynein axonemal heavy chain 8	Homo sapiens	44-50
22303248-19	2009	Both Escherichia coli and Saccharomyces cerevisiae TPS/TPP protein fusions can be used to engineer stress tolerance suggesting that metabolites rather than proteins of the trehalose pathway are key stress tolerance elicitors.	Trehalose	172-181	trehalose-6-phosphate synthase	Arabidopsis thaliana	51-54
22303248-17	2009	This supports a function for T6P as a sugar signaling molecule integrating metabolism and development in plants in relation to carbon supply.Genetic engineering of Arabidopsis as well as tobacco, potato and rice with TPS or TPS/TPP protein fusions reveals that trehalose metabolism also mediates multiple abiotic stress tolerances.	Trehalose	261-270	trehalose-6-phosphate synthase	Arabidopsis thaliana	224-227
22303248-3	2009	Firstly, trehalose-6-phosphate synthase (TPS) converts UDP-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P); secondly, T6P-phosphatase (TPP) converts T6P into trehalose and Pi.	Trehalose	9-18	trehalose-6-phosphate synthase	Arabidopsis thaliana	41-44
22303248-3	2009	Firstly, trehalose-6-phosphate synthase (TPS) converts UDP-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P); secondly, T6P-phosphatase (TPP) converts T6P into trehalose and Pi.	Trehalose	9-18	thylakoid processing peptide	Arabidopsis thaliana	133-148
22303248-17	2009	This supports a function for T6P as a sugar signaling molecule integrating metabolism and development in plants in relation to carbon supply.Genetic engineering of Arabidopsis as well as tobacco, potato and rice with TPS or TPS/TPP protein fusions reveals that trehalose metabolism also mediates multiple abiotic stress tolerances.	Trehalose	261-270	thylakoid processing peptide	Arabidopsis thaliana	228-231
22303248-3	2009	Firstly, trehalose-6-phosphate synthase (TPS) converts UDP-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P); secondly, T6P-phosphatase (TPP) converts T6P into trehalose and Pi.	Trehalose	9-18	thylakoid processing peptide	Arabidopsis thaliana	150-153
22303248-19	2009	Both Escherichia coli and Saccharomyces cerevisiae TPS/TPP protein fusions can be used to engineer stress tolerance suggesting that metabolites rather than proteins of the trehalose pathway are key stress tolerance elicitors.	Trehalose	172-181	thylakoid processing peptide	Arabidopsis thaliana	55-58
22303248-7	2009	Feeding trehalose to Arabidopsis seedlings alters carbon allocation with massive starch accumulation in cotyledons and leaves and absence of starch and growth in shoot and root apices.The Arabidopsis genome has experienced extensive radiation of genes likely encoding enzymes of T6P metabolism: 4 and 10 genes are found with homology to TPS and TPP respectively and 7 genes are found with homology to both TPS and TPP.	Trehalose	8-17	trehalose-6-phosphate synthase	Arabidopsis thaliana	337-340
22303248-7	2009	Feeding trehalose to Arabidopsis seedlings alters carbon allocation with massive starch accumulation in cotyledons and leaves and absence of starch and growth in shoot and root apices.The Arabidopsis genome has experienced extensive radiation of genes likely encoding enzymes of T6P metabolism: 4 and 10 genes are found with homology to TPS and TPP respectively and 7 genes are found with homology to both TPS and TPP.	Trehalose	8-17	thylakoid processing peptide	Arabidopsis thaliana	345-348
22303248-7	2009	Feeding trehalose to Arabidopsis seedlings alters carbon allocation with massive starch accumulation in cotyledons and leaves and absence of starch and growth in shoot and root apices.The Arabidopsis genome has experienced extensive radiation of genes likely encoding enzymes of T6P metabolism: 4 and 10 genes are found with homology to TPS and TPP respectively and 7 genes are found with homology to both TPS and TPP.	Trehalose	8-17	trehalose-6-phosphate synthase	Arabidopsis thaliana	406-409
22303248-7	2009	Feeding trehalose to Arabidopsis seedlings alters carbon allocation with massive starch accumulation in cotyledons and leaves and absence of starch and growth in shoot and root apices.The Arabidopsis genome has experienced extensive radiation of genes likely encoding enzymes of T6P metabolism: 4 and 10 genes are found with homology to TPS and TPP respectively and 7 genes are found with homology to both TPS and TPP.	Trehalose	8-17	thylakoid processing peptide	Arabidopsis thaliana	414-417
19180358-1	2009	OBJECTIVE: This randomized, double-blind, crossover study was designed to assess the effects of trehalose, a non-reducing disaccharide, alone and in combination with fructose, on postprandial serum insulin and glucose levels in obese men compared with a glucose control.	Trehalose	96-105	insulin	Homo sapiens	198-205
19180643-6	2009	Moreover, some deletion strains showed further trehalose accumulation under non-stress conditions by overexpression of the TPS1 or TPS2 genes encoding the enzymes related to trehalose biosynthesis at the mid-exponential phase.	Trehalose	47-56	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	123-127
18769872-2	2009	MATERIALS AND METHODS: Insulin with stabilizers such as mannitol and trehalose was micronized by aerosol solvent extraction system (ASES).	Trehalose	69-78	insulin	Homo sapiens	23-30
18769872-5	2009	With the incorporation of a second stabilizer trehalose (insulin/mannitol/trehalose: 15/70/15 wt.%, designated IMT), the particles were relatively uniform, more spherical, less cohesive, and less agglomerated in an air flow, when compared to IM particles.	Trehalose	46-55	insulin	Homo sapiens	57-64
19519525-0	2009	Inhibitory effects of beta-cyclodextrin and trehalose on nanofibril and AGE formation during glycation of human serum albumin.	Trehalose	44-53	albumin	Homo sapiens	112-125
19180643-6	2009	Moreover, some deletion strains showed further trehalose accumulation under non-stress conditions by overexpression of the TPS1 or TPS2 genes encoding the enzymes related to trehalose biosynthesis at the mid-exponential phase.	Trehalose	47-56	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	131-135
19180643-6	2009	Moreover, some deletion strains showed further trehalose accumulation under non-stress conditions by overexpression of the TPS1 or TPS2 genes encoding the enzymes related to trehalose biosynthesis at the mid-exponential phase.	Trehalose	174-183	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	123-127
19180643-6	2009	Moreover, some deletion strains showed further trehalose accumulation under non-stress conditions by overexpression of the TPS1 or TPS2 genes encoding the enzymes related to trehalose biosynthesis at the mid-exponential phase.	Trehalose	174-183	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	131-135
19045233-4	2008	The new revised procedure is applied on data of myoglobin in trehalose dry environment and of hydrated homologous disaccharides (sucrose and trehalose).	Trehalose	61-70	myoglobin	Homo sapiens	48-57
19026541-3	2008	Disruption of Gr5a prevents the detection of trehalose [1-3], whereas mutation of Gr64a impairs the responses to sucrose, maltose, and glucose [4, 5].	Trehalose	45-54	Gustatory receptor 5a	Drosophila melanogaster	14-18
19026541-5	2008	In the current work, we demonstrate that Gr64f is required in combination with Gr5a for the behavioral response to trehalose and for production of nerve responses to trehalose.	Trehalose	115-124	Gustatory receptor 64f	Drosophila melanogaster	41-46
19026541-5	2008	In the current work, we demonstrate that Gr64f is required in combination with Gr5a for the behavioral response to trehalose and for production of nerve responses to trehalose.	Trehalose	115-124	Gustatory receptor 5a	Drosophila melanogaster	79-83
19026541-5	2008	In the current work, we demonstrate that Gr64f is required in combination with Gr5a for the behavioral response to trehalose and for production of nerve responses to trehalose.	Trehalose	166-175	Gustatory receptor 64f	Drosophila melanogaster	41-46
19046378-5	2008	Here, we found that an AC inhibitor, MDL-12330A, depressed the response in GRNs to trehalose as well as sucrose; that an AC gene, AC78C, was expressed in the sugar-sensitive GRNs; that RNAi against AC78C depressed the electrical response in GRNs to sucrose; and that the sugar response in GRNs, as well as sugar intake in a behavioral assay in an AC78C mutant, was depressed at low sugar concentrations.	Trehalose	83-92	Adenylyl cyclase 78C	Drosophila melanogaster	23-25
19046378-5	2008	Here, we found that an AC inhibitor, MDL-12330A, depressed the response in GRNs to trehalose as well as sucrose; that an AC gene, AC78C, was expressed in the sugar-sensitive GRNs; that RNAi against AC78C depressed the electrical response in GRNs to sucrose; and that the sugar response in GRNs, as well as sugar intake in a behavioral assay in an AC78C mutant, was depressed at low sugar concentrations.	Trehalose	83-92	Adenylyl cyclase 78C	Drosophila melanogaster	130-135
18823327-8	2008	Under salt stress conditions, trehalase activity is downregulated at the transcriptional level, allowing trehalose accumulation.	Trehalose	105-114	probable trehalase	Medicago truncatula	30-39
18761403-7	2008	The presence of trehalose was shown to stabilize the bioactivity of RANKL adsorbed to brushite cement.	Trehalose	16-25	TNF superfamily member 11	Homo sapiens	68-73
19160808-2	2008	Two enzymes are capable of hydrolyzing trehalose: a neutral trehalase (NTH1) and an acidic trehalase (ATH1).	Trehalose	39-48	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	71-75
19160808-2	2008	Two enzymes are capable of hydrolyzing trehalose: a neutral trehalase (NTH1) and an acidic trehalase (ATH1).	Trehalose	39-48	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	102-106
18563901-5	2008	When starch digestion was carried out at 75 degrees C and wild-type and mutant MTHases were, respectively, used with isoamylase and maltooligosyltrehalose synthase (MTSase), the ratios of initial rates of glucose formation to those of trehalose formation were inversely correlated to the peak trehalose yields.	Trehalose	235-244	IS110 family transposase	Saccharolobus solfataricus	165-171
18407479-0	2008	Role of trehalose in moisture-induced aggregation of bovine serum albumin.	Trehalose	8-17	albumin	Homo sapiens	60-73
18555988-11	2008	Trehalose reduced hypotension, NF-kappaB binding activity, IkappaBalpha protein loss and TLR-4 activation.	Trehalose	0-9	NFKB inhibitor alpha	Rattus norvegicus	59-71
18555988-11	2008	Trehalose reduced hypotension, NF-kappaB binding activity, IkappaBalpha protein loss and TLR-4 activation.	Trehalose	0-9	toll-like receptor 4	Rattus norvegicus	89-94
18555988-12	2008	In addition trehalose reduced TNF-alpha, IL-1, IL-6 and MDA levels.	Trehalose	12-21	tumor necrosis factor	Rattus norvegicus	30-39
18555988-12	2008	In addition trehalose reduced TNF-alpha, IL-1, IL-6 and MDA levels.	Trehalose	12-21	interleukin 6	Rattus norvegicus	47-51
18452589-3	2008	Here we report the characterization of a novel Arabidopsis thaliana mutant, sweetie, with drastically altered morphogenesis, and a strongly modified carbohydrate metabolism leading to elevated levels of trehalose, trehalose-6-phosphate and starch.	Trehalose	203-212	HEAT repeat-containing protein	Arabidopsis thaliana	76-83
27877974-1	2008	A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid beta peptide (1-42) (Abeta), as evaluated by thioflavin T assay and atomic force microscopy.	Trehalose	24-33	amyloid beta precursor protein	Homo sapiens	127-132
18524936-0	2008	A role for tumour necrosis factor-alpha, complement C5 and interleukin-6 in the initiation and development of the mycobacterial cord factor trehalose 6,6"-dimycolate induced granulomatous response.	Trehalose	140-149	interleukin 6	Mus musculus	59-72
18641702-0	2008	A compensatory increase in trehalose synthesis in response to desiccation stress in Saccharomyces cerevisiae cells lacking the heat shock protein Hsp12p.	Trehalose	27-36	lipid-binding protein HSP12	Saccharomyces cerevisiae S288C	146-152
18641702-3	2008	Furthermore, the increased intracellular trehalose levels in the Deltahsp12 strain suggested that this strain compensated for the lack of Hsp12p synthesis by increasing trehalose synthesis, which facilitated increased desiccation tolerance.	Trehalose	169-178	lipid-binding protein HSP12	Saccharomyces cerevisiae S288C	138-144
18572937-8	2008	Chaotropic agents (e.g., salts, trehalose, urea, temperature) that disrupt water structure and the ability of water to mediate intermolecular hydrogen bonding also specifically expanded PIP 2 monolayers.	Trehalose	32-41	prolactin induced protein	Homo sapiens	186-189
18268028-3	2008	To further aggravate the deregulation in the pathogen, we have additionally deleted the GPR1 gene, encoding the nutrient receptor that activates the cyclic AMP-protein kinase A signaling pathway, which negatively regulates trehalose accumulation in yeasts.	Trehalose	223-232	Gpr1p	Saccharomyces cerevisiae S288C	88-92
18201973-7	2008	MBF1c is required for thermotolerance and functions upstream to SA, trehalose, ethylene, and pathogenesis-related protein 1 during heat stress.	Trehalose	68-77	multiprotein bridging factor 1C	Arabidopsis thaliana	0-5
18201973-10	2008	Our results provide evidence for the existence of a tightly coordinated heat stress-response network, involving trehalose-, SA-, and ethylene-signaling pathways, that is under the control of MBF1c.	Trehalose	112-121	multiprotein bridging factor 1C	Arabidopsis thaliana	191-196
18351334-6	2008	In contrast, in the presence of 9% ethanol, the rapid induction of TPS2 encoding trehalose-6-phosphate phosphatase resulted in trehalose accumulation.	Trehalose	81-90	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	67-71
18068693-1	2008	Several novel N-1, N-2, and S-5 tetrazole and 1,3,4-oxadiazole derivatives of alpha,alpha-trehalose disubstituted at C-6,6", with potential synthetic and pharmacological interest were prepared from commercial tetrazoles and 1,3,4-oxadiazoles in reaction with hexa-O-benzyl-6,6"-di-O-triflyl-alpha,alpha-trehalose.	Trehalose	78-99	hexosaminidase subunit alpha	Homo sapiens	259-263
18575445-0	2008	[Investigation on the effect of trehalose on alpha-actinin in cryopreserved human skin].	Trehalose	32-41	actinin alpha 1	Homo sapiens	45-58
18575445-4	2008	Furthermore, the influence of trehalose on alpha-actinin at gene level with RT-PCR was investigated.	Trehalose	30-39	actinin alpha 1	Homo sapiens	43-56
18575445-13	2008	CONCLUSION: The results suggest that cryopreservation protocol-trehalose/DMSO is better than the traditional cryoprotectant for cryopreservation on alpha-actinin of human skin.	Trehalose	63-72	actinin alpha 1	Homo sapiens	148-161
18065618-0	2008	New insights into trehalose metabolism by Saccharomyces cerevisiae: NTH2 encodes a functional cytosolic trehalase, and deletion of TPS1 reveals Ath1p-dependent trehalose mobilization.	Trehalose	18-27	alpha,alpha-trehalase NTH2	Saccharomyces cerevisiae S288C	68-72
18301741-7	2008	We also show that yeast switched from FLO11 expression to accumulation of trehalose, a STRE response controlled by a transcriptional activator Msn2/4, with decrease in the inducing concentration to complete starvation.	Trehalose	74-83	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	143-147
18205397-0	2008	Effect of trehalose on W7FW14F apomyoglobin and insulin fibrillization: new insight into inhibition activity.	Trehalose	10-19	insulin	Homo sapiens	48-55
18205397-3	2008	The aim of our study was to use two amyloid-forming proteins, i.e., W7FW14F apomyoglobin and insulin, as model systems to elucidate the molecular mechanism by which trehalose affects the amyloid aggregation process and to investigate further its therapeutic potential.	Trehalose	165-174	insulin	Homo sapiens	68-100
18205397-7	2008	In fact, trehalose dose-dependently inhibited fibril formation in the W7FW14F apomyoglobin model and increased the lag phase in the insulin model.	Trehalose	9-18	insulin	Homo sapiens	132-139
18065618-2	2008	In this work, we showed that NTH2, a paralog of NTH1, encodes a functional trehalase that is implicated in trehalose mobilization.	Trehalose	107-116	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	48-52
18065618-0	2008	New insights into trehalose metabolism by Saccharomyces cerevisiae: NTH2 encodes a functional cytosolic trehalase, and deletion of TPS1 reveals Ath1p-dependent trehalose mobilization.	Trehalose	18-27	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	131-135
18065618-3	2008	Yeast is also endowed with an acid trehalase encoded by ATH1 and an H+/trehalose transporter encoded by AGT1, which can together sustain assimilation of exogenous trehalose.	Trehalose	71-80	alpha-glucoside permease	Saccharomyces cerevisiae S288C	104-108
18065618-0	2008	New insights into trehalose metabolism by Saccharomyces cerevisiae: NTH2 encodes a functional cytosolic trehalase, and deletion of TPS1 reveals Ath1p-dependent trehalose mobilization.	Trehalose	18-27	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	144-149
18065618-4	2008	We showed that a tps1 mutant defective in the TPS catalytic subunit cultivated on trehalose, or on a dual source of carbon made of galactose and trehalose, accumulated high levels of intracellular trehalose by its Agt1p-mediated transport.	Trehalose	82-91	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	17-21
18065618-4	2008	We showed that a tps1 mutant defective in the TPS catalytic subunit cultivated on trehalose, or on a dual source of carbon made of galactose and trehalose, accumulated high levels of intracellular trehalose by its Agt1p-mediated transport.	Trehalose	145-154	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	17-21
18065618-0	2008	New insights into trehalose metabolism by Saccharomyces cerevisiae: NTH2 encodes a functional cytosolic trehalase, and deletion of TPS1 reveals Ath1p-dependent trehalose mobilization.	Trehalose	160-169	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	131-135
18065618-4	2008	We showed that a tps1 mutant defective in the TPS catalytic subunit cultivated on trehalose, or on a dual source of carbon made of galactose and trehalose, accumulated high levels of intracellular trehalose by its Agt1p-mediated transport.	Trehalose	145-154	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	17-21
18065618-7	2008	However, when the Ath1p-dependent mobilization of trehalose identified in this study was impaired, glycogen was mobilized earlier and faster, indicating a fine-tuning control in carbon storage management during periods of carbon and energy restriction.	Trehalose	50-59	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	18-23
18065618-0	2008	New insights into trehalose metabolism by Saccharomyces cerevisiae: NTH2 encodes a functional cytosolic trehalase, and deletion of TPS1 reveals Ath1p-dependent trehalose mobilization.	Trehalose	160-169	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	144-149
18065618-1	2008	In the yeast Saccharomyces cerevisiae, the synthesis of endogenous trehalose is catalyzed by a trehalose synthase complex, TPS, and its hydrolysis relies on a cytosolic/neutral trehalase encoded by NTH1.	Trehalose	67-76	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	198-202
18065618-2	2008	In this work, we showed that NTH2, a paralog of NTH1, encodes a functional trehalase that is implicated in trehalose mobilization.	Trehalose	107-116	alpha,alpha-trehalase NTH2	Saccharomyces cerevisiae S288C	29-33
19005568-5	2008	We found that DILP2 was limiting only for the increased whole-body trehalose content associated with mNSC-ablation.	Trehalose	67-76	Insulin-like peptide 2	Drosophila melanogaster	14-19
17981987-5	2008	This result from a point mutation in AtTPS6 encoding a conserved amino-terminal domain, thought to catalyze trehalose-6-phosphate synthesis and a carboxy-terminal phosphatase domain, is catalyzing a two-step conversion to trehalose.	Trehalose	108-117	UDP-Glycosyltransferase / trehalose-phosphatase family protein	Arabidopsis thaliana	37-43
17597380-3	2008	METHODS: Calmodulin (CaM, 17 kD) was co-lyophilized with carbohydrate excipients (sucrose, mannitol, trehalose, raffinose, dextran 5,000, dextran 12,000) or guanidine hydrochloride (negative control) and exposed to D2O vapor at 33% RH and RT.	Trehalose	101-110	calmodulin 1	Homo sapiens	9-19
17628825-10	2007	TPS1-TPS2 overexpressor lines were glucose insensitive, consistent with a suggested role of trehalose/T6P in modulating sugar sensing and carbohydrate metabolism.	Trehalose	92-101	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	0-4
17705272-0	2007	The crystal structure of the effector-binding domain of the trehalose repressor TreR from Bacillus subtilis 168 reveals a unique quarternary assembly.	Trehalose	60-69	transcriptional regulator (TreR-trehalose)	Bacillus subtilis subsp. subtilis str. 168	80-84
17628825-10	2007	TPS1-TPS2 overexpressor lines were glucose insensitive, consistent with a suggested role of trehalose/T6P in modulating sugar sensing and carbohydrate metabolism.	Trehalose	92-101	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	5-9
17274046-7	2007	Catalase showed 35% activity loss on rehydration of its spray freeze-drying (SFD) powder, which was improved in the TM/D (3:3:4) formulation, but not up to that level seen with either trehalose or mannitol alone.	Trehalose	184-193	catalase	Homo sapiens	0-8
17919910-7	2007	Interestingly, response to trehalose is also abolished in these flies, even though they contain a functional Gr5a gene, which has been previously shown to encode a receptor for this sugar [8, 9].	Trehalose	27-36	Gustatory receptor 5a	Drosophila melanogaster	109-113
17958330-11	2007	In conclusion, our data suggest that sucrose and trehalose as additives seems to be sufficient to protect from lyophilization of rHSA protein and also maintain its stability in the solid state during storage.	Trehalose	49-58	CD24 molecule	Rattus norvegicus	129-133
17715294-2	2007	However, only one receptor, Gr5a, has been associated with a sugar, and it appears to be activated specifically by trehalose.	Trehalose	115-124	Gustatory receptor 5a	Drosophila melanogaster	28-32
17404806-0	2007	Significance of local mobility in aggregation of beta-galactosidase lyophilized with trehalose, sucrose or stachyose.	Trehalose	85-94	galactosidase beta 1	Homo sapiens	49-67
17673210-4	2007	The full-length AtTRE1, when expressed in yeast can functionally substitute for the extracellularly active trehalase Ath1p, by sustaining the growth of an ath1 null mutant strain on trehalose and at pH 4.8.	Trehalose	182-191	trehalase 1	Arabidopsis thaliana	16-22
17673210-4	2007	The full-length AtTRE1, when expressed in yeast can functionally substitute for the extracellularly active trehalase Ath1p, by sustaining the growth of an ath1 null mutant strain on trehalose and at pH 4.8.	Trehalose	182-191	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	117-122
17531948-2	2007	We found that EMO of the transformant tps1Delta deleted of TPS1 encoding trehalose-6-phosphate synthase fluctuated unsteadily with a short wavelength in the absence of trehalose synthesis, while EMO was gradually destabilized with the wavelength increasing as storage in a frozen state was prolonged.	Trehalose	73-82	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	59-63
17286268-0	2007	Trehalose and calcium exert site-specific effects on calmodulin conformation in amorphous solids.	Trehalose	0-9	calmodulin 1	Homo sapiens	53-63
17286268-2	2007	Using calmodulin (CaM, 17 kD) as a model protein, we demonstrate that trehalose and calcium exert site-specific effects on protein conformation.	Trehalose	70-79	calmodulin 1	Homo sapiens	6-16
17286268-2	2007	Using calmodulin (CaM, 17 kD) as a model protein, we demonstrate that trehalose and calcium exert site-specific effects on protein conformation.	Trehalose	70-79	calmodulin 1	Homo sapiens	18-21
17629322-0	2007	How do trehalose, maltose, and sucrose influence some structural and dynamical properties of lysozyme? Insight from molecular dynamics simulations.	Trehalose	7-16	lysozyme	Homo sapiens	93-102
17599599-5	2007	We also show that similar protection is observed through colyophilization of CYP2D6 with trehalose.	Trehalose	89-98	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	77-83
17646889-5	2007	Additionally, molecular dynamics methods were used to show that rearrangement to a suitable conformer for lactonisation to occur happens to a lesser extent when the CCR1 inhibitor was embedded in an amorphous trehalose matrix (a model carbohydrate excipient).	Trehalose	209-218	C-C motif chemokine receptor 1	Homo sapiens	165-169
17517387-5	2007	Anthrone assay revealed that in TRH group trehalose concentration/oocyte was 2.6microM.	Trehalose	42-51	thyrotropin releasing hormone	Homo sapiens	32-35
17368048-4	2007	The presence of glycerol, sucrose, trehalose and lipids during extraction improved the thermal stability of the recombinant green cone pigment up to twofold.	Trehalose	35-44	opsin 1, medium wave sensitive	Homo sapiens	124-142
17541681-4	2007	All of these sites are predicted to be located either in loop regions or just inside membrane spanning regions, and interestingly one of the two sites in Gr68a is in a similar position to a previously described polymorphism in Gr5a that causes a shift in sensitivity to its ligand trehalose.	Trehalose	281-290	Gustatory receptor 68a	Drosophila melanogaster	154-159
17475771-4	2007	Hydrolysis of trehalose in yeast depends on neutral trehalase and acid trehalase (Ath1).	Trehalose	14-23	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	82-86
17475771-5	2007	Ath1 resides and functions in the vacuole; however, it appears to catalyze the hydrolysis of extracellular trehalose.	Trehalose	107-116	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	0-4
17453154-1	2007	Most organisms naturally accumulating trehalose upon stress produce the sugar in a two-step process by the action of the enzymes trehalose-6-phosphate synthase (TPS) and trehalose-6-phosphate phosphatase (TPP).	Trehalose	38-47	trehalose-6-phosphate synthase	Arabidopsis thaliana	129-159
17453154-1	2007	Most organisms naturally accumulating trehalose upon stress produce the sugar in a two-step process by the action of the enzymes trehalose-6-phosphate synthase (TPS) and trehalose-6-phosphate phosphatase (TPP).	Trehalose	38-47	trehalose-6-phosphate synthase	Arabidopsis thaliana	161-164
17453154-1	2007	Most organisms naturally accumulating trehalose upon stress produce the sugar in a two-step process by the action of the enzymes trehalose-6-phosphate synthase (TPS) and trehalose-6-phosphate phosphatase (TPP).	Trehalose	38-47	trehalose-6-phosphate phosphatase	Arabidopsis thaliana	170-203
17453154-1	2007	Most organisms naturally accumulating trehalose upon stress produce the sugar in a two-step process by the action of the enzymes trehalose-6-phosphate synthase (TPS) and trehalose-6-phosphate phosphatase (TPP).	Trehalose	38-47	trehalose-6-phosphate phosphatase	Arabidopsis thaliana	205-208
17453154-2	2007	Transgenic plants overexpressing TPS have shown enhanced drought tolerance in spite of minute accumulation of trehalose, amounts believed to be too small to provide a protective function.	Trehalose	110-119	trehalose-6-phosphate synthase	Arabidopsis thaliana	33-36
17541681-4	2007	All of these sites are predicted to be located either in loop regions or just inside membrane spanning regions, and interestingly one of the two sites in Gr68a is in a similar position to a previously described polymorphism in Gr5a that causes a shift in sensitivity to its ligand trehalose.	Trehalose	281-290	Gustatory receptor 5a	Drosophila melanogaster	227-231
17522728-12	2007	Finally, most membrane proteins of cryopreserved red blood cells were similar to the membrane proteins of fresh red blood cells, but trehalose can result in loss of glyceraldehyde phosphate dehydrogenase (GAPD) and peroxiredoxin 2.	Trehalose	133-142	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	205-209
17086411-6	2007	The yeast strain, which can accumulate a large amount of trehalose under normal growth conditions, has many applications and TPS1 gene in such strain may have unique use in transgenic organisms.	Trehalose	57-66	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	125-129
16977331-4	2007	However, here we show that mitochondria frozen in buffer containing the sugar, trehalose, maintained MOM integrity and responsiveness to Bcl-2-family proteins, much like fresh mitochondria.	Trehalose	79-88	B cell leukemia/lymphoma 2	Mus musculus	137-142
17522728-12	2007	Finally, most membrane proteins of cryopreserved red blood cells were similar to the membrane proteins of fresh red blood cells, but trehalose can result in loss of glyceraldehyde phosphate dehydrogenase (GAPD) and peroxiredoxin 2.	Trehalose	133-142	peroxiredoxin 2	Homo sapiens	215-230
17522728-14	2007	The cryoprotective effect of glucose may be better than that of trehalose in the presence of PVP and human serum albumin, because sugar loading process causes more cell injuries in case of trehalose compared to glucose, and these injuries in turn manifest themselves during subsequent cryopreservation and thawing.	Trehalose	64-73	albumin	Homo sapiens	107-120
17522728-14	2007	The cryoprotective effect of glucose may be better than that of trehalose in the presence of PVP and human serum albumin, because sugar loading process causes more cell injuries in case of trehalose compared to glucose, and these injuries in turn manifest themselves during subsequent cryopreservation and thawing.	Trehalose	189-198	albumin	Homo sapiens	107-120
17216712-9	2006	Our results imply up-regulation in both dauers and daf-2 mutant adults of gluconeogenesis, glyoxylate pathway activity, and trehalose biosynthesis.	Trehalose	124-133	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	51-56
17084069-8	2007	Inclusion of a more osmotically active agent, trehalose, into the vitamin B12 particles through co-lyophilization resulted in enhanced total fraction released and a faster release rate.	Trehalose	46-55	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	74-77
17182613-0	2007	Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.	Trehalose	0-9	mechanistic target of rapamycin kinase	Homo sapiens	19-23
17182613-0	2007	Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.	Trehalose	0-9	huntingtin	Homo sapiens	92-102
17182613-0	2007	Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.	Trehalose	0-9	synuclein alpha	Homo sapiens	107-122
17182613-3	2007	Here we report a novel function of trehalose as an mTOR-independent autophagy activator.	Trehalose	35-44	mechanistic target of rapamycin kinase	Homo sapiens	51-55
17182613-4	2007	Trehalose-induced autophagy enhanced the clearance of autophagy substrates like mutant huntingtin and the A30P and A53T mutants of alpha-synuclein, associated with Huntington disease (HD) and Parkinson disease (PD), respectively.	Trehalose	0-9	huntingtin	Homo sapiens	87-97
17182613-4	2007	Trehalose-induced autophagy enhanced the clearance of autophagy substrates like mutant huntingtin and the A30P and A53T mutants of alpha-synuclein, associated with Huntington disease (HD) and Parkinson disease (PD), respectively.	Trehalose	0-9	synuclein alpha	Homo sapiens	131-146
17142287-0	2007	Cytochrome C in a dry trehalose matrix: structural and dynamical effects probed by x-ray absorption spectroscopy.	Trehalose	22-31	cytochrome c, somatic	Equus caballus	0-12
17142287-9	2007	It appears, therefore, that the dried trehalose matrix dramatically perturbs the energy landscape of cytochrome c, giving rise, at the level of local structure, to well-resolved structural distortions and restricting the ensemble of accessible conformational substates.	Trehalose	38-47	cytochrome c, somatic	Equus caballus	101-113
17253797-2	2007	1H and 2H NMR investigation of reactions using stereospecifically labeled tert-butyl (2R*,3R*)-3-acetoxy-2,3-2H2-butanoate (1) and its (2R*,3S*) diastereomer (2) shows that 23 +/- 2% syn elimination occurs.	Trehalose	135-142	synemin	Homo sapiens	183-186
17145780-3	2007	Here, we show that the transcriptional activity of Hsf1 during the heat shock response depends on trehalose.	Trehalose	98-107	stress-responsive transcription factor HSF1	Saccharomyces cerevisiae S288C	51-55
17145780-6	2007	In addition, the phosphorylation levels of Hsf1 correlate with both transcriptional activity and the presence of trehalose.	Trehalose	113-122	stress-responsive transcription factor HSF1	Saccharomyces cerevisiae S288C	43-47
17145780-7	2007	These in vivo results support a new role for trehalose, where trehalose directly modifies the dynamic range of Hsf1 activity and therefore influences heat shock protein mRNA levels in response to stress.	Trehalose	45-54	stress-responsive transcription factor HSF1	Saccharomyces cerevisiae S288C	111-115
17145780-7	2007	These in vivo results support a new role for trehalose, where trehalose directly modifies the dynamic range of Hsf1 activity and therefore influences heat shock protein mRNA levels in response to stress.	Trehalose	62-71	stress-responsive transcription factor HSF1	Saccharomyces cerevisiae S288C	111-115
17031512-0	2007	ABI4 mediates the effects of exogenous trehalose on Arabidopsis growth and starch breakdown.	Trehalose	39-48	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	0-4
17031512-2	2007	Arabidopsis seedlings grown on trehalose-containing medium without sucrose display increased expression of the starch synthesis gene ApL3, hyper-accumulation of starch in the cotyledons and inhibition of root growth.	Trehalose	31-40	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	133-137
17031512-3	2007	Here we show that the ABI4 transcription factor mediates the effects of trehalose on starch metabolism and growth, independently of abscisic acid (ABA) synthesis and hexokinase (HXK1) signaling.	Trehalose	72-81	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	22-26
17031512-4	2007	Surprisingly, although the abi4 mutation partially rescued trehalose inhibition of root elongation, ApL3 expression levels were still enhanced.	Trehalose	59-68	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	27-31
17031512-6	2007	The expression of genes involved in starch breakdown, such as SEX1 and the beta-amylase gene BMY8/BAM3, was strongly down-regulated in WT plants grown on trehalose but not in abi4 mutants.	Trehalose	154-163	Pyruvate phosphate dikinase, PEP/pyruvate binding domain-containing protein	Arabidopsis thaliana	62-66
17031512-6	2007	The expression of genes involved in starch breakdown, such as SEX1 and the beta-amylase gene BMY8/BAM3, was strongly down-regulated in WT plants grown on trehalose but not in abi4 mutants.	Trehalose	154-163	chloroplast beta-amylase	Arabidopsis thaliana	93-97
17031512-6	2007	The expression of genes involved in starch breakdown, such as SEX1 and the beta-amylase gene BMY8/BAM3, was strongly down-regulated in WT plants grown on trehalose but not in abi4 mutants.	Trehalose	154-163	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	98-102
17031512-7	2007	Addition of trehalose to liquid-grown WT seedlings also significantly reduced SEX1 expression after 6 h. Bypassing the need for starch breakdown by growth in continuous light or addition of sucrose rescued root growth on trehalose medium similar to the abi4 mutation.	Trehalose	12-21	Pyruvate phosphate dikinase, PEP/pyruvate binding domain-containing protein	Arabidopsis thaliana	78-82
17031512-7	2007	Addition of trehalose to liquid-grown WT seedlings also significantly reduced SEX1 expression after 6 h. Bypassing the need for starch breakdown by growth in continuous light or addition of sucrose rescued root growth on trehalose medium similar to the abi4 mutation.	Trehalose	12-21	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	253-257
17031512-9	2007	Trehalose also significantly enhanced ABI4 expression but reduced its sucrose induction, providing a possible molecular mechanism for the trehalose effect on plant gene expression and growth.	Trehalose	0-9	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	38-42
17031512-9	2007	Trehalose also significantly enhanced ABI4 expression but reduced its sucrose induction, providing a possible molecular mechanism for the trehalose effect on plant gene expression and growth.	Trehalose	138-147	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	38-42
17172986-8	2007	Furthermore, in vivo trehalose prevented mortality in rats challenged with a lethal dose (20 mg/kg; LD90) of LPS (80% survival rate and 70% survival rate 24 and 72 h after LPS injection, respectively) and reduced serum TNF-alpha.	Trehalose	21-30	tumor necrosis factor	Rattus norvegicus	219-228
17259623-3	2007	The presence of a conserved acyltransferase motif (HX(3)DX(14)Y) suggested a role for PapA1 in acylation of sulfated trehalose to form SL-I.	Trehalose	117-126	acyltransferase	Mycobacterium tuberculosis H37Rv	86-91
17154395-7	2007	The use of trehalose as an additive for cryopreserving human hepatocytes resulted in a significantly increased total protein level in the attached cells, higher secretion of albumin and a lower aspartate aminotransferase (AST) level after thawing.	Trehalose	11-20	solute carrier family 17 member 5	Homo sapiens	194-220
17154395-7	2007	The use of trehalose as an additive for cryopreserving human hepatocytes resulted in a significantly increased total protein level in the attached cells, higher secretion of albumin and a lower aspartate aminotransferase (AST) level after thawing.	Trehalose	11-20	solute carrier family 17 member 5	Homo sapiens	222-225
17172986-7	2007	In vitro trehalose significantly blunted LPS-induced extracellular-regulated kinase (LPS = 21 +/- 6 integrated intensity; LPS + trehalose 100 mmol = 2 +/- 0.3 integrated intensity), c-jun-N terminal kinase (LPS = 15 +/- 5 integrated intensity; LPS + trehalose 100 mmol = 3.5 +/- 0.9 integrated intensity), and inducible nitric oxide synthase activation (LPS = 12 +/- 3 integrated intensity; LPS + trehalose 100 mmol = 1 +/- 0.09 integrated intensity), blunted IL-1beta (LPS = 5 +/- 1.9 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.5 +/- 0.8 n-folds/beta-actin), IL-6 (LPS = 4 +/- 1.5 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.4 +/- 0.5 n-folds/beta-actin), and TNF-alpha (LPS = 4.2 +/- 1.6 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.1 +/- 0.7 n-folds/beta-actin) gene expression, and markedly reduced the release of inflammatory cytokines and nitrite content.	Trehalose	9-18	interleukin 1 beta	Rattus norvegicus	460-468
17172986-7	2007	In vitro trehalose significantly blunted LPS-induced extracellular-regulated kinase (LPS = 21 +/- 6 integrated intensity; LPS + trehalose 100 mmol = 2 +/- 0.3 integrated intensity), c-jun-N terminal kinase (LPS = 15 +/- 5 integrated intensity; LPS + trehalose 100 mmol = 3.5 +/- 0.9 integrated intensity), and inducible nitric oxide synthase activation (LPS = 12 +/- 3 integrated intensity; LPS + trehalose 100 mmol = 1 +/- 0.09 integrated intensity), blunted IL-1beta (LPS = 5 +/- 1.9 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.5 +/- 0.8 n-folds/beta-actin), IL-6 (LPS = 4 +/- 1.5 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.4 +/- 0.5 n-folds/beta-actin), and TNF-alpha (LPS = 4.2 +/- 1.6 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.1 +/- 0.7 n-folds/beta-actin) gene expression, and markedly reduced the release of inflammatory cytokines and nitrite content.	Trehalose	9-18	actin, beta	Rattus norvegicus	494-504
17172986-7	2007	In vitro trehalose significantly blunted LPS-induced extracellular-regulated kinase (LPS = 21 +/- 6 integrated intensity; LPS + trehalose 100 mmol = 2 +/- 0.3 integrated intensity), c-jun-N terminal kinase (LPS = 15 +/- 5 integrated intensity; LPS + trehalose 100 mmol = 3.5 +/- 0.9 integrated intensity), and inducible nitric oxide synthase activation (LPS = 12 +/- 3 integrated intensity; LPS + trehalose 100 mmol = 1 +/- 0.09 integrated intensity), blunted IL-1beta (LPS = 5 +/- 1.9 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.5 +/- 0.8 n-folds/beta-actin), IL-6 (LPS = 4 +/- 1.5 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.4 +/- 0.5 n-folds/beta-actin), and TNF-alpha (LPS = 4.2 +/- 1.6 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.1 +/- 0.7 n-folds/beta-actin) gene expression, and markedly reduced the release of inflammatory cytokines and nitrite content.	Trehalose	9-18	actin, beta	Rattus norvegicus	553-563
17172986-7	2007	In vitro trehalose significantly blunted LPS-induced extracellular-regulated kinase (LPS = 21 +/- 6 integrated intensity; LPS + trehalose 100 mmol = 2 +/- 0.3 integrated intensity), c-jun-N terminal kinase (LPS = 15 +/- 5 integrated intensity; LPS + trehalose 100 mmol = 3.5 +/- 0.9 integrated intensity), and inducible nitric oxide synthase activation (LPS = 12 +/- 3 integrated intensity; LPS + trehalose 100 mmol = 1 +/- 0.09 integrated intensity), blunted IL-1beta (LPS = 5 +/- 1.9 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.5 +/- 0.8 n-folds/beta-actin), IL-6 (LPS = 4 +/- 1.5 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.4 +/- 0.5 n-folds/beta-actin), and TNF-alpha (LPS = 4.2 +/- 1.6 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.1 +/- 0.7 n-folds/beta-actin) gene expression, and markedly reduced the release of inflammatory cytokines and nitrite content.	Trehalose	9-18	interleukin 6	Rattus norvegicus	566-570
17172986-7	2007	In vitro trehalose significantly blunted LPS-induced extracellular-regulated kinase (LPS = 21 +/- 6 integrated intensity; LPS + trehalose 100 mmol = 2 +/- 0.3 integrated intensity), c-jun-N terminal kinase (LPS = 15 +/- 5 integrated intensity; LPS + trehalose 100 mmol = 3.5 +/- 0.9 integrated intensity), and inducible nitric oxide synthase activation (LPS = 12 +/- 3 integrated intensity; LPS + trehalose 100 mmol = 1 +/- 0.09 integrated intensity), blunted IL-1beta (LPS = 5 +/- 1.9 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.5 +/- 0.8 n-folds/beta-actin), IL-6 (LPS = 4 +/- 1.5 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.4 +/- 0.5 n-folds/beta-actin), and TNF-alpha (LPS = 4.2 +/- 1.6 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.1 +/- 0.7 n-folds/beta-actin) gene expression, and markedly reduced the release of inflammatory cytokines and nitrite content.	Trehalose	9-18	actin, beta	Rattus norvegicus	553-563
17172986-7	2007	In vitro trehalose significantly blunted LPS-induced extracellular-regulated kinase (LPS = 21 +/- 6 integrated intensity; LPS + trehalose 100 mmol = 2 +/- 0.3 integrated intensity), c-jun-N terminal kinase (LPS = 15 +/- 5 integrated intensity; LPS + trehalose 100 mmol = 3.5 +/- 0.9 integrated intensity), and inducible nitric oxide synthase activation (LPS = 12 +/- 3 integrated intensity; LPS + trehalose 100 mmol = 1 +/- 0.09 integrated intensity), blunted IL-1beta (LPS = 5 +/- 1.9 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.5 +/- 0.8 n-folds/beta-actin), IL-6 (LPS = 4 +/- 1.5 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.4 +/- 0.5 n-folds/beta-actin), and TNF-alpha (LPS = 4.2 +/- 1.6 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.1 +/- 0.7 n-folds/beta-actin) gene expression, and markedly reduced the release of inflammatory cytokines and nitrite content.	Trehalose	9-18	actin, beta	Rattus norvegicus	553-563
17172986-7	2007	In vitro trehalose significantly blunted LPS-induced extracellular-regulated kinase (LPS = 21 +/- 6 integrated intensity; LPS + trehalose 100 mmol = 2 +/- 0.3 integrated intensity), c-jun-N terminal kinase (LPS = 15 +/- 5 integrated intensity; LPS + trehalose 100 mmol = 3.5 +/- 0.9 integrated intensity), and inducible nitric oxide synthase activation (LPS = 12 +/- 3 integrated intensity; LPS + trehalose 100 mmol = 1 +/- 0.09 integrated intensity), blunted IL-1beta (LPS = 5 +/- 1.9 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.5 +/- 0.8 n-folds/beta-actin), IL-6 (LPS = 4 +/- 1.5 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.4 +/- 0.5 n-folds/beta-actin), and TNF-alpha (LPS = 4.2 +/- 1.6 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.1 +/- 0.7 n-folds/beta-actin) gene expression, and markedly reduced the release of inflammatory cytokines and nitrite content.	Trehalose	9-18	tumor necrosis factor	Rattus norvegicus	672-681
17172986-7	2007	In vitro trehalose significantly blunted LPS-induced extracellular-regulated kinase (LPS = 21 +/- 6 integrated intensity; LPS + trehalose 100 mmol = 2 +/- 0.3 integrated intensity), c-jun-N terminal kinase (LPS = 15 +/- 5 integrated intensity; LPS + trehalose 100 mmol = 3.5 +/- 0.9 integrated intensity), and inducible nitric oxide synthase activation (LPS = 12 +/- 3 integrated intensity; LPS + trehalose 100 mmol = 1 +/- 0.09 integrated intensity), blunted IL-1beta (LPS = 5 +/- 1.9 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.5 +/- 0.8 n-folds/beta-actin), IL-6 (LPS = 4 +/- 1.5 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.4 +/- 0.5 n-folds/beta-actin), and TNF-alpha (LPS = 4.2 +/- 1.6 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.1 +/- 0.7 n-folds/beta-actin) gene expression, and markedly reduced the release of inflammatory cytokines and nitrite content.	Trehalose	9-18	actin, beta	Rattus norvegicus	553-563
17172986-7	2007	In vitro trehalose significantly blunted LPS-induced extracellular-regulated kinase (LPS = 21 +/- 6 integrated intensity; LPS + trehalose 100 mmol = 2 +/- 0.3 integrated intensity), c-jun-N terminal kinase (LPS = 15 +/- 5 integrated intensity; LPS + trehalose 100 mmol = 3.5 +/- 0.9 integrated intensity), and inducible nitric oxide synthase activation (LPS = 12 +/- 3 integrated intensity; LPS + trehalose 100 mmol = 1 +/- 0.09 integrated intensity), blunted IL-1beta (LPS = 5 +/- 1.9 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.5 +/- 0.8 n-folds/beta-actin), IL-6 (LPS = 4 +/- 1.5 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.4 +/- 0.5 n-folds/beta-actin), and TNF-alpha (LPS = 4.2 +/- 1.6 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.1 +/- 0.7 n-folds/beta-actin) gene expression, and markedly reduced the release of inflammatory cytokines and nitrite content.	Trehalose	9-18	actin, beta	Rattus norvegicus	553-563
17159227-0	2006	CD3+ cells transfer the hypersensitive granulomatous response to mycobacterial glycolipid trehalose 6,6"-dimycolate in mice.	Trehalose	90-99	CD3 antigen, epsilon polypeptide	Mus musculus	0-3
16928328-5	2006	It is concluded that the concentrations of thrombin (1 U/ml), ristocetin (1.6 mg/ml), ADP (20 micromol/L) and collagen (2 microg/ml) are optimal for platelets aggregation tests, the internal and extracellular trehalose significantly enhance the aggregation of rehydrated-lyophilized platelets.	Trehalose	209-218	coagulation factor II, thrombin	Homo sapiens	43-51
16988267-5	2006	Sorbitol suppresses the growth defect in the tps1 and tps2 mutants at 37 degrees C, which supports the hypothesis that these sugars (trehalose and sorbitol) act primarily as stress protectants for proteins and membranes during exposure to high temperatures in C. neoformans.	Trehalose	133-142	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1	Caenorhabditis elegans	45-49
16988267-7	2006	Furthermore, in the system of the invertebrate C. elegans, in which high in vivo temperature is no longer an environmental factor, attenuation in virulence was still noted with the tps1 mutant, and this supports the hypothesis that the trehalose pathway in C. neoformans is involved in more host survival mechanisms than simply high-temperature stresses and glycolysis.	Trehalose	236-245	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1	Caenorhabditis elegans	181-185
16927180-3	2006	MATERIALS AND METHODS: Trehalose dihydrate was dehydrated isothermally at several temperatures below 100 degrees C and the anhydrous product was characterized by XRD, DSC and water vapor sorption.	Trehalose	23-42	desmocollin 3	Homo sapiens	167-170
16927180-4	2006	RESULTS: XRD and DSC suggested that the dehydration product was a partially crystalline alpha-polymorphic form of anhydrous trehalose (T(alpha)).	Trehalose	124-133	desmocollin 3	Homo sapiens	17-20
16935379-4	2006	When spray-dried alone DNase I lost almost 40% of its original biological activity, but stabilising DNase I with trehalose and PVA (DTPVA) retained 85% biological activity and trehalose, PVA and PVP (DTPVAPVP) retained 100%.	Trehalose	113-122	deoxyribonuclease 1	Homo sapiens	100-107
16968069-1	2006	The maltooligosyltrehalose trehalohydrolase (MTHase) mainly cleaves the alpha-1,4-glucosidic linkage next to the alpha-1,1-linked terminal disaccharide of maltooligosyltrehalose to produce trehalose and the maltooligosaccharide with lower molecular mass.	Trehalose	17-26	DUF4143 domain-containing protein	Saccharolobus solfataricus	45-51
16968069-7	2006	These results suggest that this MTHase could be used to produce trehalose at high temperatures.	Trehalose	64-73	DUF4143 domain-containing protein	Saccharolobus solfataricus	32-38
16882729-7	2006	Both the oga-1(ok1207) and ogt-1(ok430) strains showed elevated stores of glycogen and trehalose, and decreased lipid storage.	Trehalose	87-96	O-GlcNAc selective N-Acetyl-beta-D-glucosaminidase (O-GlcNAcase)	Caenorhabditis elegans	9-14
16734821-2	2006	Whether trehalose-loaded freeze-dried and rehydrated PLTs could regulate intracellular pH (pHi) was evaluated.	Trehalose	8-17	glucose-6-phosphate isomerase	Homo sapiens	91-94
16545359-6	2006	The results showed that the addition of PBS to the trehalose mixture causes a shift from the type II isotherm to a type III isotherm (characterized by BET equation) which may have detrimental effect on cell desiccation.	Trehalose	51-60	delta/notch like EGF repeat containing	Homo sapiens	151-154
16763022-4	2006	Second, trehalose-intake is reduced in flies heterozygous for null mutations in DGsalpha, a homolog of mammalian Gs, and trehalose-induced electrical activities in sugar-sensitive GRNs were depressed in those flies.	Trehalose	8-17	DiGeorge syndrome critical region gene 9	Homo sapiens	80-88
16763022-4	2006	Second, trehalose-intake is reduced in flies heterozygous for null mutations in DGsalpha, a homolog of mammalian Gs, and trehalose-induced electrical activities in sugar-sensitive GRNs were depressed in those flies.	Trehalose	121-130	DiGeorge syndrome critical region gene 9	Homo sapiens	80-88
16763022-6	2006	Third, expression of double-stranded RNA for DGsalpha in sugar-sensitive GRNs depressed both behavioral and electrophysiological responses to trehalose.	Trehalose	142-151	G protein alpha s subunit	Drosophila melanogaster	45-53
16763022-7	2006	Together, these findings indicate that DGsalpha is involved in trehalose perception.	Trehalose	63-72	G protein alpha s subunit	Drosophila melanogaster	39-47
16704419-4	2006	We show here that glycerol, the sugar alcohol erythritol, the disaccharide trehalose and its breakdown product glucose reduce the rate of polymerization of wild-type neuroserpin and the Ser49Pro mutant that causes dementia.	Trehalose	75-84	serpin family I member 1	Homo sapiens	166-177
19127729-8	2006	These results suggest that use of F405Y MTSase might result in a higher yield of trehalose production from starch when it replaces wild-type MTSase.	Trehalose	81-90	IS110 family transposase	Saccharolobus solfataricus	40-46
19127729-8	2006	These results suggest that use of F405Y MTSase might result in a higher yield of trehalose production from starch when it replaces wild-type MTSase.	Trehalose	81-90	IS110 family transposase	Saccharolobus solfataricus	141-147
16715386-0	2006	Beta-relaxation of insulin molecule in lyophilized formulations containing trehalose or dextran as a determinant of chemical reactivity.	Trehalose	75-84	insulin	Homo sapiens	19-26
16522328-7	2006	Our results imply up-regulation in both dauers and daf-2 mutant adults of gluconeogenesis, glyoxylate pathway activity, and trehalose biosynthesis.	Trehalose	124-133	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	51-56
16715386-10	2006	These findings suggest that the beta-relaxation of insulin is inhibited by trehalose at low humidity, presumably as a result of insulin-trehalose interaction, and thus becomes a rate determinant.	Trehalose	136-145	insulin	Homo sapiens	51-58
16715386-10	2006	These findings suggest that the beta-relaxation of insulin is inhibited by trehalose at low humidity, presumably as a result of insulin-trehalose interaction, and thus becomes a rate determinant.	Trehalose	136-145	insulin	Homo sapiens	128-135
16715386-4	2006	Furthermore, the T1rho of the insulin carbonyl carbon in the lyophilized insulin-dextran and insulin-trehalose systems was measured at 25 degrees C by 13C solid-state NMR, and the effect of trehalose and dextran on T1rho was compared at various humidities.	Trehalose	101-110	insulin	Homo sapiens	30-37
16715386-12	2006	CONCLUSIONS: Beta-relaxation rather than matrix mobility seems to be more important in determining the stability of insulin in the glassy state in lyophilized formulations containing trehalose and dextran.	Trehalose	183-192	insulin	Homo sapiens	116-123
16715386-6	2006	The insulin-dextran system exhibited a substantially greater degradation rate than the insulin-trehalose system at a given temperature below the Tg.	Trehalose	95-104	insulin	Homo sapiens	87-94
16715386-7	2006	The difference in degradation rate between the insulin-dextran and insulin-trehalose systems observed at 12% RH was eliminated at 43% RH.	Trehalose	75-84	insulin	Homo sapiens	67-74
16715386-8	2006	In addition, the T1rho of the insulin carbonyl carbon at low humidity (12% RH) was prolonged by the addition of trehalose, but not by the addition of dextran.	Trehalose	112-121	insulin	Homo sapiens	30-37
16715386-10	2006	These findings suggest that the beta-relaxation of insulin is inhibited by trehalose at low humidity, presumably as a result of insulin-trehalose interaction, and thus becomes a rate determinant.	Trehalose	75-84	insulin	Homo sapiens	51-58
16715386-10	2006	These findings suggest that the beta-relaxation of insulin is inhibited by trehalose at low humidity, presumably as a result of insulin-trehalose interaction, and thus becomes a rate determinant.	Trehalose	75-84	insulin	Homo sapiens	128-135
16371351-9	2006	Indeed, the absence of Hog1p impaired the cold-instigated expression of genes for trehalose- and glycerol-synthesizing enzymes and small chaperones.	Trehalose	82-91	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	23-28
16553903-8	2006	Through the advanced characterization of trehalose-6-P synthase1 (tps1) embryos, this approach finally provides new insight into the regulatory role played by trehalose metabolism in embryo development.	Trehalose	41-50	trehalose-6-phosphate synthase	Arabidopsis thaliana	66-70
16506754-1	2006	Interconversion dynamics of the ligand in the primary docking site of myoglobin (Mb) and hemoglobin (Hb) in trehalose and glycerol/D2O mixtures at 283 K was investigated by probing time-resolved vibrational spectra of CO photolyzed from these proteins.	Trehalose	108-117	myoglobin	Homo sapiens	70-79
16506754-1	2006	Interconversion dynamics of the ligand in the primary docking site of myoglobin (Mb) and hemoglobin (Hb) in trehalose and glycerol/D2O mixtures at 283 K was investigated by probing time-resolved vibrational spectra of CO photolyzed from these proteins.	Trehalose	108-117	myoglobin	Homo sapiens	81-83
16506754-3	2006	Interconversion rates in the heme pocket of Hb in water solution are slower than those of Mb in trehalose glass, suggesting that the interconversion barrier in Hb is intrinsically higher than that in Mb and is not modified by the solvent viscosity.	Trehalose	96-105	myoglobin	Homo sapiens	90-92
16506754-3	2006	Interconversion rates in the heme pocket of Hb in water solution are slower than those of Mb in trehalose glass, suggesting that the interconversion barrier in Hb is intrinsically higher than that in Mb and is not modified by the solvent viscosity.	Trehalose	96-105	myoglobin	Homo sapiens	200-202
16510250-4	2006	The protective effect of trehalose against oxidative damage produced by menadione was especially efficient under SOD1 deficiency.	Trehalose	25-34	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	113-117
16300984-0	2006	Mycobacterial trehalose-containing glycolipid with immunomodulatory activity on human CD4+ and CD8+ T-cells.	Trehalose	14-23	CD4 molecule	Homo sapiens	86-89
16338230-0	2006	Trehalose uptake through P2X7 purinergic channels provides dehydration protection.	Trehalose	0-9	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	25-29
16338230-2	2006	The current study explores the kinetics of loading alpha,alpha-trehalose (342 Da) into ATP stimulated J774.A1 cells, which are known to express the purinergic P2X7 receptor.	Trehalose	57-72	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	159-172
16461669-3	2006	Analysis of the Lactobacillus acidophilus NCFM genome revealed a putative trehalose utilization locus consisting of a transcriptional regulator, treR; a trehalose phosphoenolpyruvate transferase system (PTS) transporter, treB; and a trehalose-6-phosphate hydrolase, treC.	Trehalose	74-83	trehalose operon repressor	Lactobacillus acidophilus NCFM	145-149
16300984-0	2006	Mycobacterial trehalose-containing glycolipid with immunomodulatory activity on human CD4+ and CD8+ T-cells.	Trehalose	14-23	CD8a molecule	Homo sapiens	95-98
16438608-1	2006	We have carried out molecular-dynamics simulations on fully flexible all-atom models of the protein lysozyme immersed in trehalose, an effective biopreservative, with the purpose of exploring the nature and extent of the dynamical coupling between them.	Trehalose	121-130	lysozyme	Homo sapiens	100-108
16311254-6	2006	Here, we show that trehalose reduces aggregate formation and toxicity of mutant PABPN1 in cell models.	Trehalose	19-28	poly(A) binding protein, nuclear 1	Mus musculus	80-86
16383322-2	2006	Specifically, GPCR cell membrane fragments were suspended in a buffered solution containing bovine serum albumin (BSA) and disaccharide sucrose or trehalose and used for fabricating GPCR microarrays.	Trehalose	147-156	C-X-C motif chemokine receptor 6	Homo sapiens	14-18
16377847-2	2005	Validoxylamine A is structurally similar to trehalose and acts a potent competitive inhibitor of trehalase.	Trehalose	44-53	trehalase	Apis mellifera	97-106
16187303-0	2006	Disruption of insulin pathways alters trehalose level and abolishes sexual dimorphism in locomotor activity in Drosophila.	Trehalose	38-47	Insulin-like receptor	Drosophila melanogaster	14-21
16417738-8	2005	With slow-rate freezing and rapid-thawing methods modified by adding trehalose, the recovery rate of undifferentiated hES1 cells has been greatly improved from 15 to 48%.	Trehalose	69-78	glutamine amidotransferase class 1 domain containing 3	Homo sapiens	118-122
16185682-9	2005	Trehalose loaded RBCs demonstrated high survival and low levels of methemoglobin during 10 weeks of storage at 4 degrees C in the dry state when lyophilized in the presence of liposomes.	Trehalose	0-9	hemoglobin subunit gamma 2	Homo sapiens	67-80
16164606-3	2005	To incorporate trehalose into cells and utilize it, tissue cells possess the enzyme trehalase (EC3.2.1.28), which catalyses trehalose into glucose, in the organellar membrane or in the cytoplasm.	Trehalose	15-24	trehalase	Bombyx mori	84-93
16181753-8	2005	The aerosolisation performance of lysozyme or catalase formulations containing either sucrose or trehalose as stabilisers appeared to deteriorate as a function of storage time.	Trehalose	97-106	catalase	Homo sapiens	46-54
15937943-8	2005	Finally, platelets protected by the trehalose plus phosphate formulation exhibit similar aggregation response upon thrombin addition as fresh platelets, but an increase of cytosolic calcium concentration upon thrombin addition was not observed in the cryopreserved platelets.	Trehalose	36-45	coagulation factor II, thrombin	Homo sapiens	115-123
15937943-9	2005	These results suggest that trehalose and phosphate protect several aspects of platelet structure and function during cryopreservation, including an intact plasma membrane, metabolic activity, and aggregation in response to thrombin, but not intracellular calcium release in response to thrombin.	Trehalose	27-36	coagulation factor II, thrombin	Homo sapiens	223-231
16197937-9	2005	The suppression of gob-1 lethality by ablation of TPS-1 and TPS-2, the upstream enzymes in the trehalose synthesis pathway, suggests that gob-1 lethality results from a toxic build-up of the intermediate trehalose-6-phosphate, not from an absence of trehalose.	Trehalose	95-104	Trehalose-phosphatase	Caenorhabditis elegans	19-24
16197937-9	2005	The suppression of gob-1 lethality by ablation of TPS-1 and TPS-2, the upstream enzymes in the trehalose synthesis pathway, suggests that gob-1 lethality results from a toxic build-up of the intermediate trehalose-6-phosphate, not from an absence of trehalose.	Trehalose	95-104	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1	Caenorhabditis elegans	50-55
16197937-9	2005	The suppression of gob-1 lethality by ablation of TPS-1 and TPS-2, the upstream enzymes in the trehalose synthesis pathway, suggests that gob-1 lethality results from a toxic build-up of the intermediate trehalose-6-phosphate, not from an absence of trehalose.	Trehalose	95-104	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2	Caenorhabditis elegans	60-65
16197937-9	2005	The suppression of gob-1 lethality by ablation of TPS-1 and TPS-2, the upstream enzymes in the trehalose synthesis pathway, suggests that gob-1 lethality results from a toxic build-up of the intermediate trehalose-6-phosphate, not from an absence of trehalose.	Trehalose	95-104	Trehalose-phosphatase	Caenorhabditis elegans	138-143
16197937-9	2005	The suppression of gob-1 lethality by ablation of TPS-1 and TPS-2, the upstream enzymes in the trehalose synthesis pathway, suggests that gob-1 lethality results from a toxic build-up of the intermediate trehalose-6-phosphate, not from an absence of trehalose.	Trehalose	204-213	Trehalose-phosphatase	Caenorhabditis elegans	19-24
16197937-9	2005	The suppression of gob-1 lethality by ablation of TPS-1 and TPS-2, the upstream enzymes in the trehalose synthesis pathway, suggests that gob-1 lethality results from a toxic build-up of the intermediate trehalose-6-phosphate, not from an absence of trehalose.	Trehalose	204-213	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1	Caenorhabditis elegans	50-55
16197937-9	2005	The suppression of gob-1 lethality by ablation of TPS-1 and TPS-2, the upstream enzymes in the trehalose synthesis pathway, suggests that gob-1 lethality results from a toxic build-up of the intermediate trehalose-6-phosphate, not from an absence of trehalose.	Trehalose	204-213	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2	Caenorhabditis elegans	60-65
16197937-9	2005	The suppression of gob-1 lethality by ablation of TPS-1 and TPS-2, the upstream enzymes in the trehalose synthesis pathway, suggests that gob-1 lethality results from a toxic build-up of the intermediate trehalose-6-phosphate, not from an absence of trehalose.	Trehalose	204-213	Trehalose-phosphatase	Caenorhabditis elegans	138-143
16164606-3	2005	To incorporate trehalose into cells and utilize it, tissue cells possess the enzyme trehalase (EC3.2.1.28), which catalyses trehalose into glucose, in the organellar membrane or in the cytoplasm.	Trehalose	124-133	trehalase	Bombyx mori	84-93
16137568-4	2005	Here, we show that trehalose is also effective in inhibiting aggregation of Abeta and reducing its cytotoxicity, although it shows differential effects toward Abeta40 and Abeta42.	Trehalose	19-28	amyloid beta precursor protein	Homo sapiens	76-81
16137568-9	2005	These results also suggest that the use of trehalose, a highly soluble, low-priced sugar, as part of a potential therapeutic cocktail to control Abeta peptide aggregation and toxicity warrants further study.	Trehalose	43-52	amyloid beta precursor protein	Homo sapiens	145-150
15963489-3	2005	We report here that human embryonic kidney (293H) cells transfected with the gene for the stress protein p26 from Artemia and loaded with trehalose showed a sharp increase in survival during air-drying.	Trehalose	138-147	transmembrane p24 trafficking protein 3	Homo sapiens	105-108
16002092-0	2005	Stabilization of the ribosomal protein S6 by trehalose is counterbalanced by the formation of a putative off-pathway species.	Trehalose	45-54	ribosomal protein S6	Homo sapiens	21-41
16002092-1	2005	The effect of trehalose on folding and stability of the small ribosomal protein S6 was studied.	Trehalose	14-23	ribosomal protein S6	Homo sapiens	62-82
16046541-4	2005	Feeding of trehalose to Arabidopsis leaves led to stimulation of starch synthesis within 30 min, accompanied by activation of ADP-glucose pyrophosphorylase (AGPase) via posttranslational redox modification.	Trehalose	11-20	ADP-glucose pyrophosphorylase small subunit 2	Arabidopsis thaliana	126-155
16046541-4	2005	Feeding of trehalose to Arabidopsis leaves led to stimulation of starch synthesis within 30 min, accompanied by activation of ADP-glucose pyrophosphorylase (AGPase) via posttranslational redox modification.	Trehalose	11-20	ADP-glucose pyrophosphorylase small subunit 2	Arabidopsis thaliana	157-163
16085846-0	2005	Activation of the protein kinase C1 pathway upon continuous heat stress in Saccharomyces cerevisiae is triggered by an intracellular increase in osmolarity due to trehalose accumulation.	Trehalose	163-172	protein kinase C	Saccharomyces cerevisiae S288C	18-35
16046541-8	2005	Moreover, TPP expression prevented the increase in AGPase activation in response to sucrose or trehalose feeding.	Trehalose	95-104	thylakoid processing peptide	Arabidopsis thaliana	10-13
16046541-8	2005	Moreover, TPP expression prevented the increase in AGPase activation in response to sucrose or trehalose feeding.	Trehalose	95-104	ADP-glucose pyrophosphorylase small subunit 2	Arabidopsis thaliana	51-57
16085846-4	2005	It was observed that the PKC1 pathway was hardly activated in a tps1 mutant that is unable to accumulate any trehalose.	Trehalose	109-118	protein kinase C	Saccharomyces cerevisiae S288C	25-29
16085846-4	2005	It was observed that the PKC1 pathway was hardly activated in a tps1 mutant that is unable to accumulate any trehalose.	Trehalose	109-118	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	64-68
16085846-6	2005	The results of these analyses support our hypothesis that under heat stress conditions the activation of the PKC1 pathway is triggered by an increase in intracellular osmolarity, due to the accumulation of trehalose, rather than by the increase in temperature as such.	Trehalose	206-215	protein kinase C	Saccharomyces cerevisiae S288C	109-113
16078146-3	2005	METHODS: Insulin degradation and dimerization in lyophilized trehalose and PVP formulations were monitored at various relative humidities (6-60% RH) and temperatures (10-60 degrees C) by reverse-phase high-performance liquid chromatography (HPLC) and high-performance size-exclusion chromatography (HP-SEC), respectively.	Trehalose	61-70	insulin	Homo sapiens	9-16
16078146-5	2005	RESULTS: Insulin degradation in the initial stage was describable with first-order kinetics for both of the trehalose and PVP formulations.	Trehalose	108-117	insulin	Homo sapiens	9-16
16078146-6	2005	The temperature- and Tg-dependence of the degradation rate indicated that the reactivity of insulin in the trehalose formulation is affected by molecular mobility at low humidity (12% RH), such that the ratio of the observed rate constant (k") to the rate constant governed only by the activational barrier (k) was 0.051 at the Tg.	Trehalose	107-116	insulin	Homo sapiens	92-99
16078146-9	2005	CONCLUSIONS: The reactivity of insulin in the trehalose and PVP formulations can be described by an equation including factors reflecting the activational barrier (activation energy and frequency coefficient) and factors reflecting the molecular mobility (Tg, fragility parameter and a constant representing the relationship between the molecular mobility and the reaction rate).	Trehalose	46-55	insulin	Homo sapiens	31-38
15843172-0	2005	Trehalose and 6-aminohexanoic acid stabilize and renature glucose-6-phosphate dehydrogenase inactivated by glycation and by guanidinium hydrochloride.	Trehalose	0-9	glucose-6-phosphate dehydrogenase	Homo sapiens	58-91
15926040-4	2005	Interestingly, both read-outs depend on Pho81 but, while the previously described minimum domain of Pho81 is sufficient to sustain phosphate-regulated transcription of PHO genes, full-length Pho81 is required to control trehalose metabolism and the PDS targets.	Trehalose	220-229	Pho81p	Saccharomyces cerevisiae S288C	100-105
15926040-4	2005	Interestingly, both read-outs depend on Pho81 but, while the previously described minimum domain of Pho81 is sufficient to sustain phosphate-regulated transcription of PHO genes, full-length Pho81 is required to control trehalose metabolism and the PDS targets.	Trehalose	220-229	Pho81p	Saccharomyces cerevisiae S288C	100-105
16101818-0	2005	Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6"-dimycolate.	Trehalose	108-117	hemolytic complement	Mus musculus	19-32
16101818-0	2005	Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6"-dimycolate.	Trehalose	108-117	complement component 5a receptor 1	Mus musculus	41-53
15967629-0	2005	Mycobacterial trehalose 6,6"-dimycolate preferentially induces type 1 helper T cell responses through signal transducer and activator of transcription 4 protein.	Trehalose	14-23	signal transducer and activator of transcription 4	Mus musculus	102-152
15907184-0	2005	Stabilization of cold-adapted protease MCP-01 promoted by trehalose: prevention of the autolysis.	Trehalose	58-67	CD46 molecule	Homo sapiens	39-42
15907184-5	2005	In the absence of trehalose, protease MCP-01 autolyzed rapidly at 35 degrees C. However, when trehalose was added, autolysis was remarkably prevented and the loss of activity reduced.	Trehalose	94-103	CD46 molecule	Homo sapiens	38-41
15907184-6	2005	MCP-01 may be a useful model for basic research on the interaction of protein and trehalose.	Trehalose	82-91	CD46 molecule	Homo sapiens	0-3
15843172-6	2005	Both trehalose and AHA significantly protect glucose-6-phosphate dehydrogenase (G6PD) against glycation-induced inactivation, and renatured enzyme already inactivated by glycation and by guanidinium hydrochloride (GuHCl).	Trehalose	5-14	glucose-6-phosphate dehydrogenase	Homo sapiens	45-78
15843172-6	2005	Both trehalose and AHA significantly protect glucose-6-phosphate dehydrogenase (G6PD) against glycation-induced inactivation, and renatured enzyme already inactivated by glycation and by guanidinium hydrochloride (GuHCl).	Trehalose	5-14	glucose-6-phosphate dehydrogenase	Homo sapiens	80-84
15651035-11	2005	Our results suggest that the dramatic changes in S. cerevisiae HSF1 transcriptional activity in response to stress might be linked to the combined effects of trehalose and elevated temperatures in modifying the overall structure of HSF1"s C-terminal activation domain.	Trehalose	158-167	stress-responsive transcription factor HSF1	Saccharomyces cerevisiae S288C	63-67
15651035-11	2005	Our results suggest that the dramatic changes in S. cerevisiae HSF1 transcriptional activity in response to stress might be linked to the combined effects of trehalose and elevated temperatures in modifying the overall structure of HSF1"s C-terminal activation domain.	Trehalose	158-167	stress-responsive transcription factor HSF1	Saccharomyces cerevisiae S288C	232-236
15374818-1	2005	Adipokinetic hormone (AKH) is a metabolic neuropeptide principally known for its mobilization of energy substrates, notably lipid and trehalose during energy-requiring activities, such as flight and locomotion.	Trehalose	134-143	Adipokinetic hormone	Drosophila melanogaster	22-25
16851317-8	2005	All NMR experiments performed, including 1H-1H NOESY measurements, indicated that trehalose selectively interacts with the cis-olefin proton pair in the above diene with a 1:1 stoichiometry, and the C-3 (C-3") and C-6" (C-6) sites of the sugar are responsible for the interaction.	Trehalose	82-91	complement C3	Homo sapiens	199-202
16851317-8	2005	All NMR experiments performed, including 1H-1H NOESY measurements, indicated that trehalose selectively interacts with the cis-olefin proton pair in the above diene with a 1:1 stoichiometry, and the C-3 (C-3") and C-6" (C-6) sites of the sugar are responsible for the interaction.	Trehalose	82-91	complement C3	Homo sapiens	204-207
16851317-8	2005	All NMR experiments performed, including 1H-1H NOESY measurements, indicated that trehalose selectively interacts with the cis-olefin proton pair in the above diene with a 1:1 stoichiometry, and the C-3 (C-3") and C-6" (C-6) sites of the sugar are responsible for the interaction.	Trehalose	82-91	complement C6	Homo sapiens	214-217
16851317-8	2005	All NMR experiments performed, including 1H-1H NOESY measurements, indicated that trehalose selectively interacts with the cis-olefin proton pair in the above diene with a 1:1 stoichiometry, and the C-3 (C-3") and C-6" (C-6) sites of the sugar are responsible for the interaction.	Trehalose	82-91	complement C6	Homo sapiens	220-223
15374818-4	2005	Trehalose levels were decreased in larvae and starved adults, when the stimulation by AKH of the production of trehalose from fat body glycogen is no longer possible.	Trehalose	0-9	Adipokinetic hormone	Drosophila melanogaster	86-89
15374818-4	2005	Trehalose levels were decreased in larvae and starved adults, when the stimulation by AKH of the production of trehalose from fat body glycogen is no longer possible.	Trehalose	111-120	Adipokinetic hormone	Drosophila melanogaster	86-89
15516499-2	2004	Here, we report that overexpression of AtTPS1 in Arabidopsis using the 35S promoter led to a small increase in trehalose and trehalose-6-P levels.	Trehalose	111-120	trehalose-6-phosphate synthase	Arabidopsis thaliana	39-45
15496475-9	2005	Trehalose levels were elevated approximately twofold in age-1 mutants, but this increase was insufficient to prevent rapid hypertonic shrinkage.	Trehalose	0-9	Phosphatidylinositol 3-kinase age-1	Caenorhabditis elegans	56-61
15665460-3	2005	From the data of the 1H-1H coupling constants of trehalose in the presence of the alkaline-earth chlorides, it appeared that trehalose formed complexes with MgCl2, and CaCl2 at the various complexing sites: Mg2+ was coordinated to O-4 and O-4" of trehalose, and Ca2+ to O-2 and O-3.	Trehalose	125-134	immunoglobulin kappa variable 1D-37 (non-functional)	Homo sapiens	231-234
15665460-3	2005	From the data of the 1H-1H coupling constants of trehalose in the presence of the alkaline-earth chlorides, it appeared that trehalose formed complexes with MgCl2, and CaCl2 at the various complexing sites: Mg2+ was coordinated to O-4 and O-4" of trehalose, and Ca2+ to O-2 and O-3.	Trehalose	125-134	immunoglobulin kappa variable 1D-37 (non-functional)	Homo sapiens	239-242
15665460-3	2005	From the data of the 1H-1H coupling constants of trehalose in the presence of the alkaline-earth chlorides, it appeared that trehalose formed complexes with MgCl2, and CaCl2 at the various complexing sites: Mg2+ was coordinated to O-4 and O-4" of trehalose, and Ca2+ to O-2 and O-3.	Trehalose	125-134	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	262-281
15665460-3	2005	From the data of the 1H-1H coupling constants of trehalose in the presence of the alkaline-earth chlorides, it appeared that trehalose formed complexes with MgCl2, and CaCl2 at the various complexing sites: Mg2+ was coordinated to O-4 and O-4" of trehalose, and Ca2+ to O-2 and O-3.	Trehalose	125-134	immunoglobulin kappa variable 1D-37 (non-functional)	Homo sapiens	231-234
15665460-3	2005	From the data of the 1H-1H coupling constants of trehalose in the presence of the alkaline-earth chlorides, it appeared that trehalose formed complexes with MgCl2, and CaCl2 at the various complexing sites: Mg2+ was coordinated to O-4 and O-4" of trehalose, and Ca2+ to O-2 and O-3.	Trehalose	125-134	immunoglobulin kappa variable 1D-37 (non-functional)	Homo sapiens	239-242
15665460-3	2005	From the data of the 1H-1H coupling constants of trehalose in the presence of the alkaline-earth chlorides, it appeared that trehalose formed complexes with MgCl2, and CaCl2 at the various complexing sites: Mg2+ was coordinated to O-4 and O-4" of trehalose, and Ca2+ to O-2 and O-3.	Trehalose	125-134	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	262-281
15738154-0	2005	Trehalose sensitivity of the gustatory receptor neurons expressing wild-type, mutant and ectopic Gr5a in Drosophila.	Trehalose	0-9	Gustatory receptor 5a	Drosophila melanogaster	97-101
15786733-4	2005	In the present study we tested trehalose and glycerol on thermal protection of the mammalian cytosolic enzyme phosphofructokinase.	Trehalose	31-40	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	110-129
15786733-5	2005	Here we found that trehalose was able to protect phosphofructokinase against thermal inactivation as well as to promote an activation of its catalytic activity.	Trehalose	19-28	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	49-68
15667325-7	2005	We have shown that overexpression of the Arabidopsis trehalose-6-phosphate synthase gene (AtTPS1) in Arabidopsis promotes trehalose and trehalose-6-phosphate (T6P) accumulation.	Trehalose	53-62	trehalose-6-phosphate synthase	Arabidopsis thaliana	90-96
15667325-11	2005	These data suggest that AtTPS1 and accordingly T6P and trehalose play an important role in the regulation of Glc sensing and signalling genes during plant development.	Trehalose	55-64	trehalose-6-phosphate synthase	Arabidopsis thaliana	24-30
15667326-1	2005	We previously showed that trehalose-6-phosphate synthase 1 (TPS1), which catalyses the first step in trehalose synthesis, is essential for embryo maturation in Arabidopsis.	Trehalose	26-35	trehalose-6-phosphate synthase	Arabidopsis thaliana	60-64
15252058-0	2004	The ATC1 gene encodes a cell wall-linked acid trehalase required for growth on trehalose in Candida albicans.	Trehalose	79-88	Atc1p	Saccharomyces cerevisiae S288C	4-8
15228382-1	2004	We reported previously that Gts1p regulates oscillations of heat resistance in concert with those of energy metabolism in continuous cultures of the yeast Saccharomyces cerevisiae by inducing fluctuations in the levels of trehalose, but not in those of Hsp104 (heat shock protein 104).	Trehalose	222-231	Gts1p	Saccharomyces cerevisiae S288C	28-33
15228382-8	2004	Thus we suggest that Gts1p plays a major role in the oscillatory expression of TPS1 and SUC2 in continuous cultures of Saccharomyces cerevisiae, and hypothesized that Gts1p stabilizes oscillations in energy metabolism by activating trehalose synthesis to facilitate glycolysis at the shift from the respiratory to the respiro-fermentative phase.	Trehalose	232-241	Gts1p	Saccharomyces cerevisiae S288C	21-26
15228382-8	2004	Thus we suggest that Gts1p plays a major role in the oscillatory expression of TPS1 and SUC2 in continuous cultures of Saccharomyces cerevisiae, and hypothesized that Gts1p stabilizes oscillations in energy metabolism by activating trehalose synthesis to facilitate glycolysis at the shift from the respiratory to the respiro-fermentative phase.	Trehalose	232-241	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	79-83
15228382-8	2004	Thus we suggest that Gts1p plays a major role in the oscillatory expression of TPS1 and SUC2 in continuous cultures of Saccharomyces cerevisiae, and hypothesized that Gts1p stabilizes oscillations in energy metabolism by activating trehalose synthesis to facilitate glycolysis at the shift from the respiratory to the respiro-fermentative phase.	Trehalose	232-241	Gts1p	Saccharomyces cerevisiae S288C	167-172
15252058-0	2004	The ATC1 gene encodes a cell wall-linked acid trehalase required for growth on trehalose in Candida albicans.	Trehalose	79-88	trehalase (brush-border membrane glycoprotein)	Mus musculus	46-55
15252058-4	2004	Analysis of these null mutants shows that Atc1p is localized in the cell wall and is required for growth on trehalose as a carbon source.	Trehalose	108-117	Atc1p	Saccharomyces cerevisiae S288C	42-47
15260750-1	2004	Analysis of Raman and neutron scattering spectra of lysozyme demonstrates that the protein dynamics follow the dynamics of the solvents glycerol and trehalose over the entire temperature range measured 100-350 K. The protein"s fast conformational fluctuations and low-frequency vibrations and their temperature variations are very sensitive to behavior of the solvents.	Trehalose	149-158	lysozyme	Homo sapiens	52-60
15450184-5	2004	However, the real importance of trehalose in this response was veiled by the unexpected phenotypes harboured by the tps1 mutant, chosen for its inability to synthesize trehalose.	Trehalose	32-41	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	116-120
15450184-5	2004	However, the real importance of trehalose in this response was veiled by the unexpected phenotypes harboured by the tps1 mutant, chosen for its inability to synthesize trehalose.	Trehalose	168-177	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	116-120
15299033-2	2004	The best known and most widely distributed pathway of trehalose synthesis involves the transfer of glucose from UDP-glucose to glucose 6-phosphate to form trehalose-6-phosphate and UDP via the trehalose-6-phosphate synthase (TPS1).	Trehalose	54-63	tryptase alpha/beta 1	Homo sapiens	225-229
15299033-3	2004	Trehalose-6-phosphate phosphatase (TPS2) then converts trehalose-6-phosphate to free trehalose.	Trehalose	55-64	tryptase beta 2	Homo sapiens	35-39
15342513-0	2004	A single-amino-acid change of the gustatory receptor gene, Gr5a, has a major effect on trehalose sensitivity in a natural population of Drosophila melanogaster.	Trehalose	87-96	Gustatory receptor 5a	Drosophila melanogaster	59-63
15342513-7	2004	These results suggest that apart from the Gr5a gene, other genetic factors contribute to variation in trehalose sensitivity.	Trehalose	102-111	Gustatory receptor 5a	Drosophila melanogaster	42-46
15207533-6	2004	With adding either trehalose or dextran to sucrose-containing formulations, the stabilisation of lysozyme native structure could be as effective as with sucrose alone, whilst the Tg could be enhanced.	Trehalose	19-28	lysozyme	Homo sapiens	97-105
15181208-3	2004	We previously identified a mutant in the Arabidopsis trehalose biosynthesis gene AtTPS1.	Trehalose	53-62	trehalose-6-phosphate synthase	Arabidopsis thaliana	81-87
15202999-6	2004	In contrast, Gr5a, which encodes a receptor for trehalose, is expressed in a distinct and larger set of taste neurons associated with most chemosensory sensilla, including taste pegs.	Trehalose	48-57	Gustatory receptor 5a	Drosophila melanogaster	13-17
15202999-8	2004	Moreover, tetanus toxin-mediated inactivation of Gr66a- or Gr5a-expressing cells shows that these two sets of neurons mediate distinct taste modalities-the perception of bitter (caffeine) and sweet (trehalose) taste, respectively.	Trehalose	199-208	Gustatory receptor 66a	Drosophila melanogaster	49-54
15202999-8	2004	Moreover, tetanus toxin-mediated inactivation of Gr66a- or Gr5a-expressing cells shows that these two sets of neurons mediate distinct taste modalities-the perception of bitter (caffeine) and sweet (trehalose) taste, respectively.	Trehalose	199-208	Gustatory receptor 5a	Drosophila melanogaster	59-63
15181209-7	2004	Expression analysis of genes from the Arabidopsis trehalose metabolism further supports this: Suc rapidly induces expression of trehalose phosphate synthase homolog AtTPS5 to high levels.	Trehalose	50-59	trehalose phosphatase/synthase 5	Arabidopsis thaliana	165-171
15128531-6	2004	Second, Agt1p rapidly lost activity during growth on trehalose, by a mechanism similar to the sugar-induced inactivation of the maltose permease.	Trehalose	53-62	alpha-glucoside permease	Saccharomyces cerevisiae S288C	8-13
15197729-6	2004	Also, most of the structural genes involved in trehalose and glycogen synthesis and a few genes in the glyoxylate cycle and the pentose phosphate pathway are derepressed in the ssy1 and stp1 stp2 strains.	Trehalose	47-56	Ssy1p	Saccharomyces cerevisiae S288C	177-181
15197729-6	2004	Also, most of the structural genes involved in trehalose and glycogen synthesis and a few genes in the glyoxylate cycle and the pentose phosphate pathway are derepressed in the ssy1 and stp1 stp2 strains.	Trehalose	47-56	Stp1p	Saccharomyces cerevisiae S288C	186-195
15109657-0	2004	Alpha,alpha-trehalose derivatives bearing guanidino groups as inhibitors to HIV-1 Tat-TAR RNA interaction in human cells.	Trehalose	0-21	Tat	Human immunodeficiency virus 1	82-85
15128531-2	2004	However, the molecular mechanism by which extracellular trehalose can be transported to the vacuole and degraded by the acid trehalase Ath1p is not clear.	Trehalose	56-65	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	135-140
15128531-4	2004	We also found that Agt1p-mediated trehalose transport and the hydrolysis of the disaccharide by the cytosolic neutral trehalase Nth1p are coupled and represent a second, independent pathway, although there are several constraints on this alternative route.	Trehalose	34-43	alpha-glucoside permease	Saccharomyces cerevisiae S288C	19-24
15306051-5	2004	The ability of trehalose to maintain native protein structure during drying starts between 10 and 25 mM, and changes only slightly at concentrations above this threshold; with drying in 150-mM trehalose, catalase crystals yield diffraction spots out to 3.7.	Trehalose	15-24	catalase	Homo sapiens	204-212
15128531-4	2004	We also found that Agt1p-mediated trehalose transport and the hydrolysis of the disaccharide by the cytosolic neutral trehalase Nth1p are coupled and represent a second, independent pathway, although there are several constraints on this alternative route.	Trehalose	34-43	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	128-133
15006642-8	2004	Moreover, two other yeast enzymes, cytosolic pyrophosphatase and glucose 6-phosphate dehydrogenase, showed temperature dependences on inhibition by trehalose that were similar to the temperature dependence of GR inhibition.	Trehalose	148-157	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	65-98
15306051-5	2004	The ability of trehalose to maintain native protein structure during drying starts between 10 and 25 mM, and changes only slightly at concentrations above this threshold; with drying in 150-mM trehalose, catalase crystals yield diffraction spots out to 3.7.	Trehalose	193-202	catalase	Homo sapiens	204-212
14997551-6	2004	To investigate the nature of protein-trehalose-water interactions in solution at the molecular level, two molecular dynamics simulations of the protein lysozyme in solution at room temperature have been carried out, one in the presence (about 0.5 M) and one in the absence of trehalose.	Trehalose	37-46	lysozyme	Homo sapiens	152-160
14517875-4	2003	Trehalose protection had shown some promise for ToF-SIMS analysis in our previous study and was further examined with the model protein fibrinogen in this study.	Trehalose	0-9	fibrinogen beta chain	Homo sapiens	136-146
15040952-4	2004	Here, we show that in Saccharomyces cerevisiae, MG exposure increased the internal MG content and activated the expression of GLO1 and GRE3, two genes involved in MG detoxification; GPD1, the gene for glycerol synthesis; and TPS1 and TPS2, the trehalose pathway genes.	Trehalose	244-253	lactoylglutathione lyase GLO1	Saccharomyces cerevisiae S288C	126-130
15269438-7	2004	The selectable marker gene encodes the essential trehalose-6-phophate synthase, AtTPS1, that catalyzes the first reaction of the two-step trehalose synthesis.	Trehalose	49-58	trehalose-6-phosphate synthase	Arabidopsis thaliana	80-86
14608037-6	2003	The Gr5a gene on the X chromosome, which encodes a receptor for the sugar trehalose, has transposed from one such tandem cluster of six genes at cytological location 64, as has Gr61a, and all eight of these receptors might bind sugars.	Trehalose	74-83	Gustatory receptor 5a	Drosophila melanogaster	4-8
15053871-0	2004	Yeast adapt to near-freezing temperatures by STRE/Msn2,4-dependent induction of trehalose synthesis and certain molecular chaperones.	Trehalose	80-89	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	50-54
15053871-3	2004	This response involves a dramatic accumulation of the chemical chaperone trehalose and induction of trehalose-synthesizing enzymes (Tps1, Tps2) and certain heat shock proteins (Hsp104, Hsp42, Hsp12, Ssa4).	Trehalose	100-109	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	132-136
15053871-3	2004	This response involves a dramatic accumulation of the chemical chaperone trehalose and induction of trehalose-synthesizing enzymes (Tps1, Tps2) and certain heat shock proteins (Hsp104, Hsp42, Hsp12, Ssa4).	Trehalose	100-109	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	138-142
14745784-0	2004	The high general stress resistance of the Saccharomyces cerevisiae fil1 adenylate cyclase mutant (Cyr1Lys1682) is only partially dependent on trehalose, Hsp104 and overexpression of Msn2/4-regulated genes.	Trehalose	142-151	adenylate cyclase	Saccharomyces cerevisiae S288C	67-71
14745784-4	2004	Deletion of the TPS1 gene, encoding the first enzyme in the biosynthesis of trehalose, or the heat shock protein gene HSP104 only resulted in a minor effect on heat stress resistance compared with deletion of these genes in a wild-type background.	Trehalose	76-85	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	16-20
13129920-3	2003	Previous studies from our laboratory showed that over-expression of Drosophila trehalose-phosphate synthase (dtps1) increases the trehalose level and anoxia tolerance in flies.	Trehalose	79-88	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	109-114
13129920-5	2003	Glucose starvation in culture showed that HEK-293 cells transfected with pcDNA3.1(-)-dtps1 (HEK-dtps1) do not metabolize intracellular trehalose, and, interestingly, these cells accumulated intracellular trehalose during hypoxic exposure.	Trehalose	204-213	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	85-90
13129920-11	2003	Our results indicate that increased trehalose in mammalian cells following transfection by the Drosophila tps1 gene protects cells from hypoxic injury.	Trehalose	36-45	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	106-110
14523229-0	2003	Drosophila Gr5a encodes a taste receptor tuned to trehalose.	Trehalose	50-59	Gustatory receptor 5a	Drosophila melanogaster	11-15
14523229-2	2003	One of these genes, Gr5a, has been shown by genetic analysis to be required by the fly for behavioral and sensory responses to a sugar, trehalose.	Trehalose	136-145	Gustatory receptor 5a	Drosophila melanogaster	20-24
14523229-5	2003	We demonstrate by heterologous expression in a Drosophila S2 cell line that Gr5a encodes a receptor tuned to trehalose.	Trehalose	109-118	Gustatory receptor 5a	Drosophila melanogaster	76-80
14614785-2	2003	Under these conditions trehalose has an essential protective function and its concentration increases in response to enhanced expression of trehalose synthase genes, TPS1, TPS2, TPS3 and TSL1.	Trehalose	23-32	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	166-170
14614785-2	2003	Under these conditions trehalose has an essential protective function and its concentration increases in response to enhanced expression of trehalose synthase genes, TPS1, TPS2, TPS3 and TSL1.	Trehalose	23-32	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	172-176
14614785-2	2003	Under these conditions trehalose has an essential protective function and its concentration increases in response to enhanced expression of trehalose synthase genes, TPS1, TPS2, TPS3 and TSL1.	Trehalose	23-32	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	178-182
14614785-2	2003	Under these conditions trehalose has an essential protective function and its concentration increases in response to enhanced expression of trehalose synthase genes, TPS1, TPS2, TPS3 and TSL1.	Trehalose	23-32	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	187-191
14517875-5	2003	Using the combination of principal component analysis (PCA) and static ToF-SIMS analysis, we found that trehalose protection could reduce the conformation change of fibrinogen upon drying, and prevent it from unfolding and exposing hydrophobic domains.	Trehalose	104-113	fibrinogen beta chain	Homo sapiens	165-175
12782635-3	2003	Intracellular levels of Hsp104 and trehalose, which were reportedly required for the acquisition of heat tolerance in the stationary phase of cell growth, were affected in both GTS1 mutants roughly in proportion to the gene dosage of GTS1, whereas those of other Hsps were less affected.	Trehalose	35-44	Gts1p	Saccharomyces cerevisiae S288C	177-181
13678635-3	2003	In C. elegans two putative trehalose-6-phosphate synthase (tps) genes encode the enzymes that catalyse trehalose synthesis and five putative trehalase (tre) genes encode enzymes catalysing hydrolysis of the sugar.	Trehalose	27-36	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2	Caenorhabditis elegans	59-62
13678635-8	2003	We did not observe an obvious phenotype for any of the genes silenced individually but gas-chromatographic analysis showed &gt;90% decline in trehalose levels when both tps genes were targeted simultaneously.	Trehalose	142-151	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2	Caenorhabditis elegans	169-172
12782635-3	2003	Intracellular levels of Hsp104 and trehalose, which were reportedly required for the acquisition of heat tolerance in the stationary phase of cell growth, were affected in both GTS1 mutants roughly in proportion to the gene dosage of GTS1, whereas those of other Hsps were less affected.	Trehalose	35-44	Gts1p	Saccharomyces cerevisiae S288C	234-238
12689634-5	2003	The growth rate dependency of trehalose accumulation was supported by studies in cells overexpressing the G(1)-cyclin CLN3.	Trehalose	30-39	cyclin CLN3	Saccharomyces cerevisiae S288C	118-122
12702728-4	2003	Among them, RNase A has been used as a model enzyme to investigate the effect of trehalose on the retention of enzymatic activity upon incubation at high temperatures.	Trehalose	81-90	ribonuclease A family member 1, pancreatic	Homo sapiens	12-19
12702728-5	2003	2 m trehalose was observed to raise the transition temperature, Tm of RNase A by as much as 18 degrees C and Gibbs free energy by 4.8 kcal mol-1 at pH 2.5.	Trehalose	4-13	ribonuclease A family member 1, pancreatic	Homo sapiens	70-77
12748054-2	2003	Trehalose synthesis in yeast is mediated by a complex of trehalose-6-phosphate synthase (TPS1) and trehalose-6-phosphate phosphatase (TPS2).	Trehalose	0-9	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	89-93
12748054-2	2003	Trehalose synthesis in yeast is mediated by a complex of trehalose-6-phosphate synthase (TPS1) and trehalose-6-phosphate phosphatase (TPS2).	Trehalose	0-9	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	134-138
12689634-6	2003	The trehalose level appeared to be dependent on the duration of the G(1) phase, as trehalose was only accumulated at a G(1) phase duration of more than 5 h in both wild-type and CLN3-overexpressing cells.	Trehalose	4-13	cyclin CLN3	Saccharomyces cerevisiae S288C	178-182
12689634-6	2003	The trehalose level appeared to be dependent on the duration of the G(1) phase, as trehalose was only accumulated at a G(1) phase duration of more than 5 h in both wild-type and CLN3-overexpressing cells.	Trehalose	83-92	cyclin CLN3	Saccharomyces cerevisiae S288C	178-182
12604583-8	2003	This indicates that hypertrehalosaemia is not acutely toxic, whereas lack of glucose causes organ failure (presumably of the nervous system), and that sufficient haemolymph glucose can only be generated from trehalose by trehalase.	Trehalose	208-217	trehalase	Homo sapiens	221-230
12761667-0	2003	Synthesis of a new vanadyl(IV) complex with trehalose (TreVO): insulin-mimetic activities in osteoblast-like cells in culture.	Trehalose	44-53	insulin	Homo sapiens	63-70
12695020-4	2003	The preparation of L-asparaginase nanospheres with trehalose, PEG 400, and glycerol as components of the inner aqueous phase yielded colloidal formulations with increased biological activity as determined by an improved protocol for quantification of the active enzyme encapsulated.	Trehalose	51-60	asparaginase and isoaspartyl peptidase 1	Homo sapiens	19-33
12698493-0	2003	The fourth helical secondary structure of beta-peptides: the (P)-28-helix of a beta-hexapeptide consisting of (2R,3S)-3-amino-2-hydroxy acid residues.	Trehalose	110-117	amyloid beta precursor protein	Homo sapiens	77-83
12586876-2	2003	Trehalose-producing, transgenic rice (Oryza sativa) plants were generated by the introduction of a gene encoding a bifunctional fusion (TPSP) of the trehalose-6-phosphate (T-6-P) synthase (TPS) and T-6-P phosphatase (TPP) of Escherichia coli, under the control of the maize (Zea mays) ubiquitin promoter (Ubi1).	Trehalose	0-9	alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1-like	Nicotiana tabacum	136-139
12604583-1	2003	The main blood sugar of locusts is trehalose, which is hydrolysed to two glucose units by trehalase.	Trehalose	35-44	trehalase	Homo sapiens	90-99
12603162-1	2003	The fluorescence intensity-time records of individual metal-free porphyrin cytochrome-c and Zn porphyrin cytochrome-c molecules whose translational motions are restricted by encapsulation in trehalose are examined by single-molecule spectroscopy by means of a two-channel confocal microscope that records transient fluorescence signals in two orthogonal polarization directions.	Trehalose	191-200	cytochrome c, somatic	Homo sapiens	105-117
12586876-2	2003	Trehalose-producing, transgenic rice (Oryza sativa) plants were generated by the introduction of a gene encoding a bifunctional fusion (TPSP) of the trehalose-6-phosphate (T-6-P) synthase (TPS) and T-6-P phosphatase (TPP) of Escherichia coli, under the control of the maize (Zea mays) ubiquitin promoter (Ubi1).	Trehalose	0-9	trehalose-phosphate phosphatase A-like	Nicotiana tabacum	217-220
12800502-0	2003	Trehalose, glycogen and ethanol metabolism in the gcr1 mutant of Saccharomyces cerevisiae.	Trehalose	0-9	transcription regulator GCR1	Saccharomyces cerevisiae S288C	50-54
12800502-1	2003	Since Gcr1p is pivotal in controlling the transcription of glycolytic enzymes and trehalose metabolism seems to be one of the control points of glycolysis, we examined trehalose and glycogen synthesis in response to 2% glucose pulse during batch growth in gcr1 (glucose regulation-1) mutant lacking fully functional glycolytic pathway and in the wild-type strain.	Trehalose	168-177	transcription regulator GCR1	Saccharomyces cerevisiae S288C	6-11
12527978-10	2003	Pre-exercise ingestion of trehalose and galactose resulted in lower plasma glucose and insulin responses prior to exercise and reduced the prevalence of rebound hypoglycaemia.	Trehalose	26-35	insulin	Homo sapiens	87-94
12892531-0	2003	Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose.	Trehalose	94-103	taste 1 receptor member 3	Homo sapiens	15-19
12892531-3	2003	We demonstrate for the first time that the candidate sweet taste receptor T1R3 is essential for the recognition and response to the disaccharide trehalose.	Trehalose	145-154	taste 1 receptor member 3	Homo sapiens	74-78
11895938-1	2002	Deletion of trehalose-6-phosphate phosphatase, encoded by TPS2, in Saccharomyces cerevisiae results in accumulation of trehalose-6-phosphate (Tre6P) instead of trehalose under stress conditions.	Trehalose	12-21	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	58-62
12508064-2	2003	In arabidopsis disruption of the first step of trehalose synthesis, catalysed by trehalose-6-phosphate synthase (TPS), has lethal consequences, demonstrating an important physiological role.	Trehalose	47-56	trehalose-6-phosphate synthase	Arabidopsis thaliana	81-111
12508064-2	2003	In arabidopsis disruption of the first step of trehalose synthesis, catalysed by trehalose-6-phosphate synthase (TPS), has lethal consequences, demonstrating an important physiological role.	Trehalose	47-56	trehalose-6-phosphate synthase	Arabidopsis thaliana	113-116
12523665-3	2002	RESULTS: Small molecular excipients (glycerol, sorbitol, 1,6-anhydroglucose, sucrose, and trehalose) were found to stabilize the activity and/or the native structure of freeze-dried lysozyme and catalase, despite the processing temperatures being above Tg" of excipent-protein mixtures.	Trehalose	90-99	catalase	Homo sapiens	195-203
12191695-4	2002	In this study, bovine insulin was dissolved in deionized water alone or with tyloxapol, lactose or trehalose.	Trehalose	99-108	insulin	Bos taurus	22-29
11978181-3	2002	Overexpression of the plant genes in a Saccharomyces cerevisiae tps1 mutant results in very low TPS-catalytic activity and trehalose accumulation.	Trehalose	123-132	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	64-68
11978181-4	2002	We show that truncation of the plant-specific N-terminal extension in the A. thaliana AtTPS1 and S. lepidophylla SlTPS1 homologues results in 10-40-fold higher TPS activity and 20-40-fold higher trehalose accumulation on expression in yeast.	Trehalose	195-204	trehalose-6-phosphate synthase	Arabidopsis thaliana	86-92
12071726-0	2002	Trehalose glass-facilitated thermal reduction of metmyoglobin and methemoglobin.	Trehalose	0-9	hemoglobin subunit gamma 2	Homo sapiens	66-79
11719513-4	2002	We first cloned the gene trehalose-6-phosphate synthase (tps1), which synthesizes trehalose, and examined the effect of tps1 overexpression as well as mutation on the resistance of Drosophila to anoxia.	Trehalose	25-34	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	57-61
11948532-9	2002	Trehalose and lactose decreased relaxation rates in the lysozyme-sugar systems while hydration increased relaxation rates that were correlated with changes in aggregation and activity of the protein.	Trehalose	0-9	lysozyme	Homo sapiens	56-64
11719513-5	2002	Upon induction of tps1, trehalose increased, and this was associated with increased tolerance to anoxia.	Trehalose	24-33	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	18-22
12630316-0	2002	The GCR1 gene function is essential for glycogen and trehalose metabolism in Saccharomyces cerevisiae.	Trehalose	53-62	transcription regulator GCR1	Saccharomyces cerevisiae S288C	4-8
11779242-3	2002	By varying the temperature (-15 to 65 degrees C) and humidity for samples of carbonmonoxy myoglobin embedded in trehalose-glass, it is possible to observe a hierarchy of distinct geminate recombination phases that extend from nanosecond to almost seconds that can be directly associated with rebinding from specific hydrophobic cavities.	Trehalose	112-121	myoglobin	Homo sapiens	90-99
11963965-0	2002	Trehalose augments osteoprotegerin production in the FHs74Int human intestinal epithelial cell line.	Trehalose	0-9	TNF receptor superfamily member 11b	Homo sapiens	19-34
11963965-3	2002	We report here for the first time that a human intestinal epithelial cell line, FHs74Int, also produces osteoprotegerin (OPG) and that trehalose augments OPG production by this cell line.	Trehalose	135-144	TNF receptor superfamily member 11b	Homo sapiens	154-157
11963965-4	2002	Thus, these results suggest that trehalose promotes the production of OPG by intestinal epithelial cells, which then acts on bone marrow cells, resulting in the suppression of osteoclastogenesis.	Trehalose	33-42	TNF receptor superfamily member 11b	Homo sapiens	70-73
11517217-8	2001	Systematic dose responses of glycine betaine, glycerol, proline, and trehalose revealed a regulatory effect on the folding activities of individual and combinations of chaperones GroEL, DnaK, and ClpB.	Trehalose	69-78	GroEL	Escherichia coli	179-184
11851922-0	2002	Trehalose-6-phosphate synthase 1, which catalyses the first step in trehalose synthesis, is essential for Arabidopsis embryo maturation.	Trehalose	68-77	trehalose-6-phosphate synthase	Arabidopsis thaliana	0-32
11851922-2	2002	Here we report on an Arabidopsis mutant (tps1), disrupted in a gene encoding the first enzyme of trehalose biosynthesis (trehalose-6-phosphate synthase).	Trehalose	97-106	trehalose-6-phosphate synthase	Arabidopsis thaliana	41-45
11851922-2	2002	Here we report on an Arabidopsis mutant (tps1), disrupted in a gene encoding the first enzyme of trehalose biosynthesis (trehalose-6-phosphate synthase).	Trehalose	97-106	trehalose-6-phosphate synthase	Arabidopsis thaliana	121-151
11704765-4	2001	In two different mutants that carry deletions in Gr5a, electrophysiological and behavioral responses to trehalose were diminished but the response to sucrose was unaffected.	Trehalose	104-113	Gustatory receptor 5a	Drosophila melanogaster	49-53
11704765-5	2001	Transgenic rescue experiments showed that Gr5a confers response to trehalose.	Trehalose	67-76	Gustatory receptor 5a	Drosophila melanogaster	42-46
11517217-10	2001	High osmolyte concentrations, especially trehalose, strongly inhibited DnaK-dependent chaperone networks, such as DnaK+GroEL and DnaK+ClpB, likely because high viscosity affects dynamic interactions between chaperones and folding substrates and stabilizes protein aggregates.	Trehalose	41-50	GroEL	Escherichia coli	119-124
11672518-9	2001	Of the three bioantioxidants tested, i.e., ascorbic acid, alpha-tocopherol acetate, and catalase, catalase shows maximum cryoprotective effect both at -196 degrees C and at -80 degrees C. Because the mode of cryoprotective action of catalase and trehalose are totally different, we tried a combination of these two compounds along with 10% DMSO.	Trehalose	246-255	catalase	Homo sapiens	88-96
11672518-9	2001	Of the three bioantioxidants tested, i.e., ascorbic acid, alpha-tocopherol acetate, and catalase, catalase shows maximum cryoprotective effect both at -196 degrees C and at -80 degrees C. Because the mode of cryoprotective action of catalase and trehalose are totally different, we tried a combination of these two compounds along with 10% DMSO.	Trehalose	246-255	catalase	Homo sapiens	98-106
11672518-9	2001	Of the three bioantioxidants tested, i.e., ascorbic acid, alpha-tocopherol acetate, and catalase, catalase shows maximum cryoprotective effect both at -196 degrees C and at -80 degrees C. Because the mode of cryoprotective action of catalase and trehalose are totally different, we tried a combination of these two compounds along with 10% DMSO.	Trehalose	246-255	catalase	Homo sapiens	98-106
11520870-0	2001	Trehalose metabolism in Arabidopsis: occurrence of trehalose and molecular cloning and characterization of trehalose-6-phosphate synthase homologues.	Trehalose	0-9	trehalose-6-phosphate synthase	Arabidopsis thaliana	107-137
11566105-0	2001	Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a.	Trehalose	0-9	Gustatory receptor 5a	Drosophila melanogaster	111-115
11520870-3	2001	In a variety of organisms, the synthesis of trehalose is catalysed by trehalose-6-phosphate synthase (TPS; EC 2.4.1.15) and trehalose-6-phosphate phosphatase (TPP; EC 3.1.3.12).	Trehalose	44-53	trehalose-6-phosphate synthase	Arabidopsis thaliana	70-100
11520870-3	2001	In a variety of organisms, the synthesis of trehalose is catalysed by trehalose-6-phosphate synthase (TPS; EC 2.4.1.15) and trehalose-6-phosphate phosphatase (TPP; EC 3.1.3.12).	Trehalose	44-53	trehalose-6-phosphate synthase	Arabidopsis thaliana	102-105
11520870-3	2001	In a variety of organisms, the synthesis of trehalose is catalysed by trehalose-6-phosphate synthase (TPS; EC 2.4.1.15) and trehalose-6-phosphate phosphatase (TPP; EC 3.1.3.12).	Trehalose	44-53	trehalose-6-phosphate phosphatase	Arabidopsis thaliana	124-157
11520870-3	2001	In a variety of organisms, the synthesis of trehalose is catalysed by trehalose-6-phosphate synthase (TPS; EC 2.4.1.15) and trehalose-6-phosphate phosphatase (TPP; EC 3.1.3.12).	Trehalose	44-53	trehalose-6-phosphate phosphatase	Arabidopsis thaliana	159-162
11520870-10	2001	The results indicate that while AtTPS1 is involved in the formation of trehalose in Arabidopsis, some of the Arabidopsis genes with homologies to known TPS/TPP genes encode proteins lacking catalytic activity in trehalose synthesis.	Trehalose	71-80	trehalose-6-phosphate synthase	Arabidopsis thaliana	32-38
11520870-10	2001	The results indicate that while AtTPS1 is involved in the formation of trehalose in Arabidopsis, some of the Arabidopsis genes with homologies to known TPS/TPP genes encode proteins lacking catalytic activity in trehalose synthesis.	Trehalose	71-80	trehalose-6-phosphate synthase	Arabidopsis thaliana	34-37
11520870-10	2001	The results indicate that while AtTPS1 is involved in the formation of trehalose in Arabidopsis, some of the Arabidopsis genes with homologies to known TPS/TPP genes encode proteins lacking catalytic activity in trehalose synthesis.	Trehalose	212-221	trehalose-6-phosphate synthase	Arabidopsis thaliana	32-38
11520870-10	2001	The results indicate that while AtTPS1 is involved in the formation of trehalose in Arabidopsis, some of the Arabidopsis genes with homologies to known TPS/TPP genes encode proteins lacking catalytic activity in trehalose synthesis.	Trehalose	212-221	trehalose-6-phosphate synthase	Arabidopsis thaliana	34-37
11520870-10	2001	The results indicate that while AtTPS1 is involved in the formation of trehalose in Arabidopsis, some of the Arabidopsis genes with homologies to known TPS/TPP genes encode proteins lacking catalytic activity in trehalose synthesis.	Trehalose	212-221	trehalose-6-phosphate phosphatase	Arabidopsis thaliana	156-159
11580836-0	2001	Lre1 affects chitinase expression, trehalose accumulation and heat resistance through inhibition of the Cbk1 protein kinase in Saccharomyces cerevisiae.	Trehalose	35-44	Lre1p	Saccharomyces cerevisiae S288C	0-4
11580836-3	2001	Overexpression of LRE1 in a wild-type strain causes the same phenotype as observed in strains with reduced activity of the cAMP-PKA pathway: higher heat resistance and enhanced trehalose levels.	Trehalose	177-186	Lre1p	Saccharomyces cerevisiae S288C	18-22
11580836-11	2001	In addition, we show that increased trehalose accumulation and increased heat resistance caused by overexpression of LRE1 are also the result of inhibition of Cbk1, revealing a novel control pathway for certain targets affected by PKA.	Trehalose	36-45	Lre1p	Saccharomyces cerevisiae S288C	117-121
11580836-11	2001	In addition, we show that increased trehalose accumulation and increased heat resistance caused by overexpression of LRE1 are also the result of inhibition of Cbk1, revealing a novel control pathway for certain targets affected by PKA.	Trehalose	36-45	serine/threonine protein kinase CBK1	Saccharomyces cerevisiae S288C	159-163
11410278-2	2001	Single particle analysis from electron micrographs of Prx-II molecules homogeneously orientated across holes in the presence of a thin film of ammonium molybdate and trehalose has facilitated the production of a &gt;/=20 A 3-D reconstruction by angular reconstitution that emphasises the D5 symmetry of the ring-like decamer.	Trehalose	166-175	peroxiredoxin 2	Homo sapiens	54-60
11446983-2	2001	Also, trehalose inhibits the secretion of interleukin-6 in bone marrow cell cultures, resulting in a decrease in osteoclast formation.	Trehalose	6-15	interleukin 6	Mus musculus	42-55
11446983-5	2001	Trehalose significantly suppressed LPS-induced tumor necrosis factor (TNF)-alpha production after 90 min and decreased the number of osteoclasts in the bone marrow 48 hours after LPS injection.	Trehalose	0-9	toll-like receptor 4	Mus musculus	35-38
11446983-5	2001	Trehalose significantly suppressed LPS-induced tumor necrosis factor (TNF)-alpha production after 90 min and decreased the number of osteoclasts in the bone marrow 48 hours after LPS injection.	Trehalose	0-9	tumor necrosis factor	Mus musculus	47-80
11446983-5	2001	Trehalose significantly suppressed LPS-induced tumor necrosis factor (TNF)-alpha production after 90 min and decreased the number of osteoclasts in the bone marrow 48 hours after LPS injection.	Trehalose	0-9	toll-like receptor 4	Mus musculus	179-182
11446983-6	2001	These results indicate that trehalose suppresses excessive osteoclastogenesis not only in OVX mice but also in a LPS-induced bone resorption mouse model and further suggest that the latter finding may be mediated at least in part through a decrease in TNF-alpha production.	Trehalose	28-37	toll-like receptor 4	Mus musculus	113-116
11446983-6	2001	These results indicate that trehalose suppresses excessive osteoclastogenesis not only in OVX mice but also in a LPS-induced bone resorption mouse model and further suggest that the latter finding may be mediated at least in part through a decrease in TNF-alpha production.	Trehalose	28-37	tumor necrosis factor	Mus musculus	252-261
11402215-0	2001	Induction of ApL3 expression by trehalose complements the starch-deficient Arabidopsis mutant adg2-1 lacking ApL1, the large subunit of ADP-glucose pyrophosphorylase.	Trehalose	32-41	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	13-17
11402215-0	2001	Induction of ApL3 expression by trehalose complements the starch-deficient Arabidopsis mutant adg2-1 lacking ApL1, the large subunit of ADP-glucose pyrophosphorylase.	Trehalose	32-41	ADP glucose pyrophosphorylase large subunit 1	Arabidopsis thaliana	109-113
12702465-5	2001	On the other hand, the alpha-glucoside permease encoded by the AGT1 gene had a high affinity (K(m) approximately 7 mM) for trehalose, a low affinity (K(m) approximately 18 mM) for maltose and maltotriose, and a very low affinity (K(m) approximately 35 mM) for alpha-methylglucoside.	Trehalose	123-132	alpha-glucoside permease	Saccharomyces cerevisiae S288C	63-67
11402215-2	2001	In Arabidopsis seedlings, growth on trehalose-containing medium leads to an inhibition of root elongation, an accumulation of starch in the shoots, an increased activity of ADP-Glc pyrophosphorylase (AGPase), and an induction of the expression of the AGPase gene, ApL3 (A. Wingler, T. Fritzius, A. Wiemken, T. Boller, R.A. Aeschbacher [2000] Plant Physiol 124: 105-114).	Trehalose	36-45	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	264-268
11402215-4	2001	In a mutant lacking the large AGPase subunit, ApL1, (adg2-1 mutant) growth on trehalose restored AGPase activity and led to a strong accumulation of starch in the shoots.	Trehalose	78-87	ADP glucose pyrophosphorylase large subunit 1	Arabidopsis thaliana	46-50
11402215-7	2001	In addition, root elongation in the mutants, especially in the adg1-1 mutant, was partially resistant to trehalose, suggesting that the induction of ApL3 expression and the resulting accumulation of starch in the shoots were partially responsible for the effects of trehalose on the growth of wild-type plants.	Trehalose	105-114	ADP glucose pyrophosphorylase 1	Arabidopsis thaliana	63-69
11402215-7	2001	In addition, root elongation in the mutants, especially in the adg1-1 mutant, was partially resistant to trehalose, suggesting that the induction of ApL3 expression and the resulting accumulation of starch in the shoots were partially responsible for the effects of trehalose on the growth of wild-type plants.	Trehalose	105-114	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	149-153
11402215-7	2001	In addition, root elongation in the mutants, especially in the adg1-1 mutant, was partially resistant to trehalose, suggesting that the induction of ApL3 expression and the resulting accumulation of starch in the shoots were partially responsible for the effects of trehalose on the growth of wild-type plants.	Trehalose	266-275	ADP glucose pyrophosphorylase 1	Arabidopsis thaliana	63-69
11402215-7	2001	In addition, root elongation in the mutants, especially in the adg1-1 mutant, was partially resistant to trehalose, suggesting that the induction of ApL3 expression and the resulting accumulation of starch in the shoots were partially responsible for the effects of trehalose on the growth of wild-type plants.	Trehalose	266-275	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	149-153
11389981-6	2001	Addition of excess trehalose increased the rate of release from the PLG.	Trehalose	19-28	plasminogen	Homo sapiens	68-71
11334630-0	2001	Effect of trehalose in low concentration on the binding and transport of porphyrins in liposome-human serum albumin system.	Trehalose	10-19	albumin	Homo sapiens	102-115
11334630-1	2001	The influence of trehalose on the interaction of liposomes with porphyrins and with human serum albumin (HSA) was studied.	Trehalose	17-26	albumin	Homo sapiens	90-103
11329880-7	2001	From the result above, we could conclude that the TPS1 gene of S. cerevisiae was able to restore otsA gene function in E. coli for both osmotolerance and trehalose accumulation during salt stress.	Trehalose	154-163	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	50-54
11206185-8	2001	FTIR data showed that the structure of the BSA-trehalose formulation encapsulated into PLG microspheres was less perturbed than that of BSA obtained from buffer alone.	Trehalose	47-56	plasminogen	Homo sapiens	87-90
33873340-8	2001	Trehalose also enhanced phenylalanine ammonia-lyase (PAL) and peroxidase (PO) activities; both markers of plant defence responses.	Trehalose	0-9	wali4	Triticum aestivum	24-51
33873340-8	2001	Trehalose also enhanced phenylalanine ammonia-lyase (PAL) and peroxidase (PO) activities; both markers of plant defence responses.	Trehalose	0-9	peroxidase-like	Triticum aestivum	62-72
11055939-6	2000	The genes represented by HAC1, PRY1, and ICT1 have been reported to be associated with cell stress, and AGT1 and GAC1 have been reported to be involved in the uptake of trehalose and the production of glycogen, respectively.	Trehalose	169-178	alpha-glucoside permease	Saccharomyces cerevisiae S288C	104-108
11055939-6	2000	The genes represented by HAC1, PRY1, and ICT1 have been reported to be associated with cell stress, and AGT1 and GAC1 have been reported to be involved in the uptake of trehalose and the production of glycogen, respectively.	Trehalose	169-178	protein phosphatase regulator GAC1	Saccharomyces cerevisiae S288C	113-117
10931304-2	2000	It has been speculated that trehalose protects proteins and membranes under environmental stress conditions, but recently it was shown to assist the Hsp104 chaperone in refolding of heat-damaged proteins in the yeast cytosol.	Trehalose	28-37	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	149-155
11083487-6	2000	RESULTS: When 30 g of trehalose were administered orally to six subjects with the low trehalase activity, blood glucose and insulin levels scarcely elevated after loading.	Trehalose	22-31	insulin	Homo sapiens	124-131
11083487-9	2000	Yet, decreases in blood insulin levels in the trehalose loading experiment were delayed in comparison with the same amount of glucose ingestion, and peak insulin levels were significantly lower than those with glucose ingestion (P&lt;0.01).	Trehalose	46-55	insulin	Homo sapiens	24-31
10982426-0	2000	Trehalose induces the ADP-glucose pyrophosphorylase gene, ApL3, and starch synthesis in Arabidopsis.	Trehalose	0-9	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	58-62
10982426-5	2000	The accumulation of starch in the shoots of trehalose-treated seedlings was accompanied by an increased activity of ADP-glucose pyrophosphorylase and an induction of the expression of the ADP-glucose pyrophosphorylase gene, ApL3.	Trehalose	44-53	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	224-228
10982426-6	2000	Even in the presence of 50 mM Suc, which itself also slightly induced ApL3, trehalose (5 mM) led to a further increase in ApL3 expression.	Trehalose	76-85	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	122-126
10982426-8	2000	Furthermore, trehalose induced the expression of the beta-amylase gene, AT-beta-Amy, in combination with Suc but not when trehalose was supplied alone, indicating that trehalose can modulate sugar-mediated gene expression.	Trehalose	13-22	beta-amylase 5	Arabidopsis thaliana	72-83
11055939-6	2000	The genes represented by HAC1, PRY1, and ICT1 have been reported to be associated with cell stress, and AGT1 and GAC1 have been reported to be involved in the uptake of trehalose and the production of glycogen, respectively.	Trehalose	169-178	transcription factor HAC1	Saccharomyces cerevisiae S288C	25-29
11055939-6	2000	The genes represented by HAC1, PRY1, and ICT1 have been reported to be associated with cell stress, and AGT1 and GAC1 have been reported to be involved in the uptake of trehalose and the production of glycogen, respectively.	Trehalose	169-178	sterol-binding protein	Saccharomyces cerevisiae S288C	31-35
11055939-6	2000	The genes represented by HAC1, PRY1, and ICT1 have been reported to be associated with cell stress, and AGT1 and GAC1 have been reported to be involved in the uptake of trehalose and the production of glycogen, respectively.	Trehalose	169-178	lysophosphatidic acid acyltransferase ICT1	Saccharomyces cerevisiae S288C	41-45
10884225-2	2000	Employing a differential screening strategy, we identified a taste receptor gene, Tre1, that controls the taste sensitivity to trehalose in Drosophila melanogaster.	Trehalose	127-136	Trapped in endoderm 1	Drosophila melanogaster	82-86
10884225-4	2000	Disruption of the Tre1 gene lowered the taste sensitivity to trehalose, whereas sensitivities to other sugars were unaltered.	Trehalose	61-70	Trapped in endoderm 1	Drosophila melanogaster	18-22
10884225-5	2000	Overexpression of the Tre1 gene restored the taste sensitivity to trehalose in the Tre1 deletion mutant.	Trehalose	66-75	Trapped in endoderm 1	Drosophila melanogaster	22-26
10884225-5	2000	Overexpression of the Tre1 gene restored the taste sensitivity to trehalose in the Tre1 deletion mutant.	Trehalose	66-75	Trapped in endoderm 1	Drosophila melanogaster	83-87
10884225-7	2000	These results provide direct evidence that Tre1 encodes a putative taste receptor for trehalose in Drosophila.	Trehalose	86-95	Trapped in endoderm 1	Drosophila melanogaster	43-47
10901163-1	2000	In yeast, trehalose-6-phosphate synthase is a key enzyme for trehalose biosynthesis, encoded by the structural gene TPS1.	Trehalose	10-19	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	116-120
10811893-13	2000	Tpk2 negatively regulates genes involved in iron uptake and positively regulates genes involved in trehalose degradation and water homeostasis.	Trehalose	99-108	cAMP-dependent protein kinase catalytic subunit TPK2	Saccharomyces cerevisiae S288C	0-4
10841782-8	2000	The reduction of trans-2-octenoyl-CoA catalyzed by InhA resulted in the syn addition of (2)H(2) across the double bond yielding (2R,3S)-?2, 3-(2)H(2)octanoyl-CoA.	Trehalose	128-135	inhibin subunit alpha	Rattus norvegicus	51-55
10957961-5	2000	The high-affinity trehalose-H+ symporter encoded by the AGT1 gene is required for growth on trehalose.	Trehalose	18-27	alpha-glucoside permease	Saccharomyces cerevisiae S288C	56-60
10791714-1	2000	Strains of Saccharomyces cerevisiae deleted for TPS1 encoding trehalose-6-phosphate synthase still accumulate trehalose when harbouring a functional MAL locus.	Trehalose	62-71	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	48-52
10791714-3	2000	The uptake of trehalose was shown to be mediated by the alpha-glucoside transporter encoded by AGT1, the expression of which is linked to the presence of a functional MAL locus.	Trehalose	14-23	alpha-glucoside permease	Saccharomyces cerevisiae S288C	95-99
10791714-4	2000	Deletion of this gene in a MAL+ tps1 mutant abolished trehalose accumulation on a maltose or galactose mineral medium.	Trehalose	54-63	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	32-36
10791714-5	2000	However, small amounts of disaccharide were still detected in a agt1 tps1 double mutant when the medium was supplemented with 10 g trehalose l(-1), indicating the existence of a non-concentrative low-affinity sugar transporter.	Trehalose	131-140	alpha-glucoside permease	Saccharomyces cerevisiae S288C	64-73
10722600-0	2000	Trehalose 6,6"-dimycolate (Cord factor) enhances neovascularization through vascular endothelial growth factor production by neutrophils and macrophages.	Trehalose	0-9	vascular endothelial growth factor A	Mus musculus	76-110
10794745-1	2000	BACKGROUND: alpha,alpha-Trehalase, located on renal proximal tubules, is a glycoprotein that hydrolyses alpha,alpha-trehalose to two glucose molecules.	Trehalose	110-125	trehalase	Homo sapiens	24-33
10675505-6	2000	HSP 12 was found to act in an analogous manner to trehalose and protect liposomal membrane integrity against desiccation.	Trehalose	50-59	lipid-binding protein HSP12	Saccharomyces cerevisiae S288C	0-6
10957961-5	2000	The high-affinity trehalose-H+ symporter encoded by the AGT1 gene is required for growth on trehalose.	Trehalose	92-101	alpha-glucoside permease	Saccharomyces cerevisiae S288C	56-60
10361302-11	1999	Deletion of Gpr1 and/or Gpa2 affected cAPK-controlled features (levels of trehalose, glycogen, heat resistance, expression of STRE-controlled genes and ribosomal protein genes) specifically during the transition to growth on glucose.	Trehalose	74-83	Gpr1p	Saccharomyces cerevisiae S288C	12-16
10941794-1	1999	The alpha-amylase from Sulfolobus solfataricus has the commercially important ability to hydrolyze glycosyltrehalose and can be used for the production of trehalose from soluble starch.	Trehalose	107-116	glycoside hydrolase family 57 protein	Saccharolobus solfataricus	4-17
10368160-0	1999	AGT1, encoding an alpha-glucoside transporter involved in uptake and intracellular accumulation of trehalose in Saccharomyces cerevisiae.	Trehalose	99-108	alpha-glucoside permease	Saccharomyces cerevisiae S288C	0-4
10368160-3	1999	The trehalose found in a tps1 mutant of trehalose synthase may therefore largely reflect its uptake from the enriched medium that was employed.	Trehalose	4-13	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	25-29
10652100-1	2000	Saccharomyces cerevisiae neutral trehalase, encoded by NTH1, controls trehalose hydrolysis in response to multiple stress conditions, including nutrient limitation.	Trehalose	70-79	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	55-59
10652100-7	2000	The trehalose concentration in the msn2 msn4 double mutant increases less during heat stress and drops more slowly during recovery than in wild-type cells.	Trehalose	4-13	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	35-39
10652100-7	2000	The trehalose concentration in the msn2 msn4 double mutant increases less during heat stress and drops more slowly during recovery than in wild-type cells.	Trehalose	4-13	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	40-44
10652100-8	2000	This shows that Msn2/Msn4-controlled expression of enzymes of trehalose synthesis and hydrolysis help to maintain trehalose concentration during stress.	Trehalose	62-71	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	16-20
10652100-8	2000	This shows that Msn2/Msn4-controlled expression of enzymes of trehalose synthesis and hydrolysis help to maintain trehalose concentration during stress.	Trehalose	62-71	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	21-25
10652100-8	2000	This shows that Msn2/Msn4-controlled expression of enzymes of trehalose synthesis and hydrolysis help to maintain trehalose concentration during stress.	Trehalose	114-123	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	16-20
10652100-8	2000	This shows that Msn2/Msn4-controlled expression of enzymes of trehalose synthesis and hydrolysis help to maintain trehalose concentration during stress.	Trehalose	114-123	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	21-25
10652100-9	2000	However, the Msn2/Msn4-independent mechanism exists for heat control of trehalose metabolism.	Trehalose	72-81	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	13-17
10652100-9	2000	However, the Msn2/Msn4-independent mechanism exists for heat control of trehalose metabolism.	Trehalose	72-81	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	18-22
10652100-15	2000	These results might help to elucidate the general connection between control by STREs, Msn2/Msn4 and PKA and, in particular, how these components play a role in control of trehalose metabolism.	Trehalose	172-181	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	87-91
10652100-15	2000	These results might help to elucidate the general connection between control by STREs, Msn2/Msn4 and PKA and, in particular, how these components play a role in control of trehalose metabolism.	Trehalose	172-181	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	92-96
10594371-0	1999	Combined effects of trehalose and cations on the thermal resistance of beta-galactosidase in freeze-dried systems.	Trehalose	20-29	galactosidase beta 1	Homo sapiens	71-89
10594371-1	1999	The purpose of this study was to investigate the combined effects of trehalose and cations on the preservation of beta-galactosidase in freeze-dried systems and their relationship to physical properties.	Trehalose	69-78	galactosidase beta 1	Homo sapiens	114-132
10523302-5	1999	Overexpression of RGS2 generates phenotypes consistent with low activity of cAMP-dependent protein kinase A (PKA), such as enhanced accumulation of trehalose and glycogen, enhanced heat resistance and elevated expression of STRE-controlled genes.	Trehalose	148-157	GTPase-activating protein RGS2	Saccharomyces cerevisiae S288C	18-22
10361302-11	1999	Deletion of Gpr1 and/or Gpa2 affected cAPK-controlled features (levels of trehalose, glycogen, heat resistance, expression of STRE-controlled genes and ribosomal protein genes) specifically during the transition to growth on glucose.	Trehalose	74-83	guanine nucleotide-binding protein subunit alpha	Saccharomyces cerevisiae S288C	24-28
9916036-0	1999	Harmonic behavior of trehalose-coated carbon-monoxy-myoglobin at high temperature.	Trehalose	21-30	myoglobin	Homo sapiens	52-61
9916036-3	1999	In this paper we report on the low-frequency dynamics of carbon monoxy myoglobin in an extremely dry trehalose glass measured by neutron spectroscopy.	Trehalose	101-110	myoglobin	Homo sapiens	71-80
9887287-1	1999	Conventional and enhanced 1D experiments and different NOESY experiments (the 2D unbiased method) were performed for measuring CSA/DD cross-correlated relaxation on trehalose, a compound which could be approximated as a spherical top, and on simple model compounds comprising C3v symmetry (CHCl3, triphenylsilane (TPSi)).	Trehalose	165-174	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	127-130
9919656-6	1999	This weak-acid-induced trehalose accumulation is enhanced in the pfk1 S. cerevisiae mutant, indicating that it arises through inhibition of glycolysis at the phosphofructokinase step.	Trehalose	23-32	6-phosphofructokinase subunit alpha	Saccharomyces cerevisiae S288C	65-69
9919658-1	1999	The AGT1 permease is a alpha-glucoside-H+ symporter responsible for the active transport of maltose, trehalose, maltotriose, alpha-methylglucoside, melezitose and sucrose.	Trehalose	101-110	alpha-glucoside permease	Saccharomyces cerevisiae S288C	4-8
10077186-3	1999	Under glucose limitation, genes involved in glycogen and trehalose biosynthesis (GLG1, GSY1, GSY2, GAC1, GLC3, TPS1), in their degradation (GPH1, NTHI), and the typical stress-responsive CTT1 gene were coordinately induced in parallel with glycogen, when the growth has left the pure exponential phase and while glucose was still plentiful in the medium.	Trehalose	57-66	glycogenin glucosyltransferase GLG1	Saccharomyces cerevisiae S288C	81-85
10077186-3	1999	Under glucose limitation, genes involved in glycogen and trehalose biosynthesis (GLG1, GSY1, GSY2, GAC1, GLC3, TPS1), in their degradation (GPH1, NTHI), and the typical stress-responsive CTT1 gene were coordinately induced in parallel with glycogen, when the growth has left the pure exponential phase and while glucose was still plentiful in the medium.	Trehalose	57-66	glycogen (starch) synthase GSY1	Saccharomyces cerevisiae S288C	87-91
10077186-3	1999	Under glucose limitation, genes involved in glycogen and trehalose biosynthesis (GLG1, GSY1, GSY2, GAC1, GLC3, TPS1), in their degradation (GPH1, NTHI), and the typical stress-responsive CTT1 gene were coordinately induced in parallel with glycogen, when the growth has left the pure exponential phase and while glucose was still plentiful in the medium.	Trehalose	57-66	glycogen (starch) synthase GSY2	Saccharomyces cerevisiae S288C	93-97
10077186-3	1999	Under glucose limitation, genes involved in glycogen and trehalose biosynthesis (GLG1, GSY1, GSY2, GAC1, GLC3, TPS1), in their degradation (GPH1, NTHI), and the typical stress-responsive CTT1 gene were coordinately induced in parallel with glycogen, when the growth has left the pure exponential phase and while glucose was still plentiful in the medium.	Trehalose	57-66	protein phosphatase regulator GAC1	Saccharomyces cerevisiae S288C	99-103
10077186-3	1999	Under glucose limitation, genes involved in glycogen and trehalose biosynthesis (GLG1, GSY1, GSY2, GAC1, GLC3, TPS1), in their degradation (GPH1, NTHI), and the typical stress-responsive CTT1 gene were coordinately induced in parallel with glycogen, when the growth has left the pure exponential phase and while glucose was still plentiful in the medium.	Trehalose	57-66	1,4-alpha-glucan branching enzyme	Saccharomyces cerevisiae S288C	105-109
10077186-3	1999	Under glucose limitation, genes involved in glycogen and trehalose biosynthesis (GLG1, GSY1, GSY2, GAC1, GLC3, TPS1), in their degradation (GPH1, NTHI), and the typical stress-responsive CTT1 gene were coordinately induced in parallel with glycogen, when the growth has left the pure exponential phase and while glucose was still plentiful in the medium.	Trehalose	57-66	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	111-115
10077186-3	1999	Under glucose limitation, genes involved in glycogen and trehalose biosynthesis (GLG1, GSY1, GSY2, GAC1, GLC3, TPS1), in their degradation (GPH1, NTHI), and the typical stress-responsive CTT1 gene were coordinately induced in parallel with glycogen, when the growth has left the pure exponential phase and while glucose was still plentiful in the medium.	Trehalose	57-66	glycogen phosphorylase	Saccharomyces cerevisiae S288C	140-144
10077186-4	1999	Trehalose accumulation was delayed until the diauxic shift, although TPS1 was induced much earlier, due to hydrolysis of trehalose by high trehalase activity.	Trehalose	121-130	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	69-73
9917346-3	1998	The presence of ethanol was shown to slow down the inactivation of mALT, increasing its half-life from 1 to 4 h. Trehalose was found to greatly enhance the stability of mALT in a concentration-dependent manner.	Trehalose	113-122	glutamic pyruvic transaminase, soluble	Mus musculus	169-173
9915893-3	1999	The activity of trehalase, an enzyme that metabolizes trehalose to glucose, was measured in rabbit serum and kidney.	Trehalose	54-63	trehalase	Oryctolagus cuniculus	16-25
9915893-6	1999	12 g.kg-1 on d 1) of trehalose for 5 d. Trehalase activity resembled maltase activity, both being high in the renal cortex (2.04 +/- 0.71 and 2.93 +/- 0.26 micromol.g-1.min-1, respectively), weak in the medulla, and undetectable in the serum.	Trehalose	21-30	trehalase	Oryctolagus cuniculus	40-49
9915893-7	1999	Serum glucose and insulin concentrations were increased significantly by trehalose infusion.	Trehalose	73-82	insulin	Oryctolagus cuniculus	18-25
9917346-2	1998	In this report we examine the possibility of stabilizing mALT with ethanol, trehalose, and protease inhibitors.	Trehalose	76-85	glutamic pyruvic transaminase, soluble	Mus musculus	57-61
9917346-3	1998	The presence of ethanol was shown to slow down the inactivation of mALT, increasing its half-life from 1 to 4 h. Trehalose was found to greatly enhance the stability of mALT in a concentration-dependent manner.	Trehalose	113-122	glutamic pyruvic transaminase, soluble	Mus musculus	67-71
9837904-4	1998	Deletion of TPS1 totally abolished TPS activity and measurable trehalose, whereas deletion of any of the other genes in most cases reduced both.	Trehalose	63-72	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	12-16
9837904-7	1998	Since we observed measurable trehalose in strains lacking all but the TPS1 gene, some phosphatase activity in addition to Tps2 can hydrolyze trehalose 6-phosphate.	Trehalose	29-38	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	70-74
9837904-8	1998	Deletion of TPS3, in particular in a tsl1Delta background, reduced both TPS and TPP activities and trehalose content.	Trehalose	99-108	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	12-16
9837904-15	1998	We discuss the possible role of differentially regulated Tps1 in a complex-bound or monomeric form in light of the requirement of Tps1 for trehalose production and for growth on glucose and fructose.	Trehalose	139-148	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	130-134
9917346-4	1998	In the presence of 36.5% trehalose, the half-life of mALT was 85 h. Of the protease inhibitors tested only antipain and chymostatin slowed down the inactivation of mALT but only within the first 24 h following preparation of the crude enzyme.	Trehalose	25-34	glutamic pyruvic transaminase, soluble	Mus musculus	53-57
9917346-4	1998	In the presence of 36.5% trehalose, the half-life of mALT was 85 h. Of the protease inhibitors tested only antipain and chymostatin slowed down the inactivation of mALT but only within the first 24 h following preparation of the crude enzyme.	Trehalose	25-34	glutamic pyruvic transaminase, soluble	Mus musculus	164-168
9797287-6	1998	The substrate specificity of TSase was very strict: among eight disaccharides examined, only trehalose was phosphorolyzed, and only alpha-D-glucose 1-P served as a donor substrate with D-glucose as the acceptor in trehalose synthesis.	Trehalose	94-103	thymidylate synthetase	Homo sapiens	30-35
9797287-6	1998	The substrate specificity of TSase was very strict: among eight disaccharides examined, only trehalose was phosphorolyzed, and only alpha-D-glucose 1-P served as a donor substrate with D-glucose as the acceptor in trehalose synthesis.	Trehalose	215-224	thymidylate synthetase	Homo sapiens	30-35
9797287-0	1998	Purification and characterization of a trehalose synthase from the basidiomycete grifola frondosa A trehalose synthase (TSase) that catalyzes the synthesis of trehalose from D-glucose and alpha-D-glucose 1-phosphate (alpha-D-glucose 1-P) was detected in a basidiomycete, Grifola frondosa.	Trehalose	40-49	thymidylate synthetase	Homo sapiens	121-126
9797287-8	1998	In system I, the alpha-D-glucose 1-P liberated by 1.05 U of sucrose phosphorylase was linked with D-glucose by 1.05 U of TSase, generating trehalose at the initial synthesis rate of 18 mmol/h in a final yield of 90 mol% under optimum conditions (300 mM each sucrose and glucose, 20 mM inorganic phosphate, 37.5 degreesC, and pH 6.5).	Trehalose	140-149	thymidylate synthetase	Homo sapiens	122-127
9797287-3	1998	Although TSase catalyzed the phosphorolysis of trehalose to D-glucose and alpha-D-glucose 1-P, in addition to the synthesis of trehalose from the two substrates, the TSase equilibrium strongly favors trehalose synthesis.	Trehalose	48-57	thymidylate synthetase	Homo sapiens	10-15
9797287-3	1998	Although TSase catalyzed the phosphorolysis of trehalose to D-glucose and alpha-D-glucose 1-P, in addition to the synthesis of trehalose from the two substrates, the TSase equilibrium strongly favors trehalose synthesis.	Trehalose	48-57	thymidylate synthetase	Homo sapiens	167-172
9797287-3	1998	Although TSase catalyzed the phosphorolysis of trehalose to D-glucose and alpha-D-glucose 1-P, in addition to the synthesis of trehalose from the two substrates, the TSase equilibrium strongly favors trehalose synthesis.	Trehalose	128-137	thymidylate synthetase	Homo sapiens	10-15
9797287-3	1998	Although TSase catalyzed the phosphorolysis of trehalose to D-glucose and alpha-D-glucose 1-P, in addition to the synthesis of trehalose from the two substrates, the TSase equilibrium strongly favors trehalose synthesis.	Trehalose	128-137	thymidylate synthetase	Homo sapiens	167-172
9797287-3	1998	Although TSase catalyzed the phosphorolysis of trehalose to D-glucose and alpha-D-glucose 1-P, in addition to the synthesis of trehalose from the two substrates, the TSase equilibrium strongly favors trehalose synthesis.	Trehalose	128-137	thymidylate synthetase	Homo sapiens	10-15
9797287-3	1998	Although TSase catalyzed the phosphorolysis of trehalose to D-glucose and alpha-D-glucose 1-P, in addition to the synthesis of trehalose from the two substrates, the TSase equilibrium strongly favors trehalose synthesis.	Trehalose	128-137	thymidylate synthetase	Homo sapiens	167-172
9797333-1	1998	Disruption of the HSP104 gene in a mutant which cannot accumulate trehalose during heat shock treatment caused trehalose accumulation (H. Iwahashi, K. Obuchi, S. Fujii, and Y. Komatsu, Lett.	Trehalose	66-75	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	18-24
9797333-1	1998	Disruption of the HSP104 gene in a mutant which cannot accumulate trehalose during heat shock treatment caused trehalose accumulation (H. Iwahashi, K. Obuchi, S. Fujii, and Y. Komatsu, Lett.	Trehalose	111-120	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	18-24
9797333-4	1998	This implies that Hsp104 affects trehalose metabolism.	Trehalose	33-42	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	18-24
9797333-6	1998	The activities of trehalose-synthesizing and -hydrolyzing enzymes are low in the HSP104 disruption mutant during heat shock.	Trehalose	18-27	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	81-87
9797333-7	1998	This data is correlated with intracellular trehalose and glucose levels observed in the HSP104 disruption mutant.	Trehalose	43-52	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	88-94
9797333-8	1998	These results suggest that during heat shock, Hsp104 contributes to the simultaneous increase in both accumulation and degradation of trehalose.	Trehalose	134-143	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	46-52
9811499-1	1998	We have investigated the effect of mannitol, sorbitol, methyl alpha-D-mannopyranoside, lactose, trehalose, and cellobiose on the stability and structure of the pharmaceutical protein recombinant human growth hormone (rhGH) in the lyophilized state.	Trehalose	96-105	growth hormone 1	Homo sapiens	201-215
9374502-5	1997	Treatment of cells with dihydrosphingosine activates transcription of the TPS2 gene encoding a subunit of trehalose synthase and causes trehalose, a known thermoprotectant, to accumulate.	Trehalose	106-115	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	74-78
9813347-3	1998	The glucose/trehalose system preserved glucose-6-phosphate dehydrogenase better than did the glucose/sucrose system with the same glass transition temperature (Tg).	Trehalose	12-21	glucose-6-phosphate dehydrogenase	Homo sapiens	39-72
9744870-2	1998	Here, we show that loss of Rim15p causes an additional pleiotropic phenotype in cells grown to stationary phase on rich medium; this phenotype includes defects in trehalose and glycogen accumulation, in transcriptional derepression of HSP12, HSP26, and SSA3, in induction of thermotolerance and starvation resistance, and in proper G1 arrest.	Trehalose	163-172	protein kinase RIM15	Saccharomyces cerevisiae S288C	27-33
9681010-4	1998	On the other hand, expression of the AtTPS1 cDNA in the yeast tps1 mutant restored its ability to synthesize trehalose and suppressed its growth defect related to the lack of trehalose-6-phosphate.	Trehalose	109-118	trehalose-6-phosphate synthase	Arabidopsis thaliana	37-43
9681010-4	1998	On the other hand, expression of the AtTPS1 cDNA in the yeast tps1 mutant restored its ability to synthesize trehalose and suppressed its growth defect related to the lack of trehalose-6-phosphate.	Trehalose	109-118	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	62-66
9468339-6	1998	Our results also suggest that the recently characterized AGT1 gene of S. cerevisiae may encode the high-affinity trehalose-H+ symporter.	Trehalose	113-122	alpha-glucoside permease	Saccharomyces cerevisiae S288C	57-61
10950639-0	1998	A reduction of protein specific motions in co-ligated myoglobin embedded in a trehalose glass.	Trehalose	78-87	myoglobin	Homo sapiens	54-63
9308367-7	1998	The role of the putative trehalase Nth2p in trehalose metabolism is not known.	Trehalose	44-53	alpha,alpha-trehalase NTH2	Saccharomyces cerevisiae S288C	35-40
9628870-8	1998	Stimulation by glucose was dependent on the Galpha-protein Gpa2, whose deletion confers the typical phenotype associated with a reduced cAMP level: higher heat resistance, a higher level of trehalose and glycogen and elevated expression of STRE-controlled genes.	Trehalose	190-199	guanine nucleotide-binding protein subunit alpha	Saccharomyces cerevisiae S288C	59-63
9579083-1	1998	A pma1-1 mutant of Saccharomyces cerevisiae with reduced H(+)-ATPase activity and the isogenic wild-type strain accumulated high levels of trehalose in response to a temperature upshift to 40 degrees C and after addition of 10% ethanol, but only modest levels in response to a rapid drop in external pH and after addition of decanoic acid.	Trehalose	139-148	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	2-8
9579083-6	1998	Another finding was that a pma1-1 mutant exhibited a two- to threefold greater capacity to accumulate trehalose than the isogenic wild-type.	Trehalose	102-111	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	27-33
9534237-7	1998	The mutant strains unable to produce trehalose (tps1 delta tps2 delta and tps1 delta hxk2 delta) were more sensitive to severe osmotic stress (0.866 aw) than the isogenic wild-type strain, confirming a role for trehalose in survival.	Trehalose	37-46	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	48-95
9534237-7	1998	The mutant strains unable to produce trehalose (tps1 delta tps2 delta and tps1 delta hxk2 delta) were more sensitive to severe osmotic stress (0.866 aw) than the isogenic wild-type strain, confirming a role for trehalose in survival.	Trehalose	211-220	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	48-95
9534237-8	1998	Hyperaccumulation of trehalose found in the nth1 delta and the nth1 delta gpd1 delta mutant strains, however, did not improve survival rates compared to the wild-type strain.	Trehalose	21-30	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	44-48
9534237-8	1998	Hyperaccumulation of trehalose found in the nth1 delta and the nth1 delta gpd1 delta mutant strains, however, did not improve survival rates compared to the wild-type strain.	Trehalose	21-30	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	63-67
9534237-8	1998	Hyperaccumulation of trehalose found in the nth1 delta and the nth1 delta gpd1 delta mutant strains, however, did not improve survival rates compared to the wild-type strain.	Trehalose	21-30	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1	Saccharomyces cerevisiae S288C	74-78
9427410-5	1997	In contrast, haploid elm1-15 TRP1 cells grow well in budding form on all media, are stress resistant and overaccumulate trehalose.	Trehalose	120-129	serine/threonine protein kinase ELM1	Saccharomyces cerevisiae S288C	21-25
9413144-1	1997	The thermal stability of enzymes lactase and invertase in dried, amorphous matrices of sugars (trehalose, maltose, lactose, sucrose, raffinose) and some other selected systems (casein, PVP, milk) was studied.	Trehalose	95-104	lactase	Homo sapiens	33-40
9315717-2	1997	The CIF1 gene (allelic to GGS1 and TPS1) encodes a subunit of the trehalose synthase complex that affects trehalose synthesis.	Trehalose	66-75	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	4-8
9315717-2	1997	The CIF1 gene (allelic to GGS1 and TPS1) encodes a subunit of the trehalose synthase complex that affects trehalose synthesis.	Trehalose	66-75	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	26-30
9315717-2	1997	The CIF1 gene (allelic to GGS1 and TPS1) encodes a subunit of the trehalose synthase complex that affects trehalose synthesis.	Trehalose	66-75	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	35-39
9276477-7	1997	Heat-induced expression of the NTH1 gene is shown to be accompanied by accumulation of trehalose.	Trehalose	87-96	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	31-35
9276477-10	1997	Participation of neutral trehalase (Nth1p) in multiple stress response dependent and independent on trehalose is discussed.	Trehalose	100-109	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	36-41
9145529-1	1997	Glycosyl-trehaloses with an isomaltosyl residue were synthesized by alpha-glucosidase from Aspergillus niger by using maltotetraose as a glucosyl donor and trehalose as the acceptor.	Trehalose	9-18	sucrase-isomaltase	Homo sapiens	68-85
9228765-2	1997	Experimental evidence showed that viability for both strains decreased with increasing pressure and that tps1 mutants, unable to accumulate trehalose, were more sensitive to hydrostatic pressure than the wild-type cells.	Trehalose	140-149	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	105-109
9228765-3	1997	Additionally, both tps1 and wild-type cells in the stationary phase, when there is an accumulation of endogenous trehalose, were more resistant to pressure than proliferating cells.	Trehalose	113-122	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	19-23
9188709-0	1997	Trehalose prevents myoglobin collapse and preserves its internal mobility.	Trehalose	0-9	myoglobin	Physeter catodon	19-28
9188709-1	1997	A quantitative model, which involves diffusion on a temperature-dependent potential, is utilized to analyze the time-dependence of geminate CO recombination to sperm whale myoglobin in a trehalose glass and the accompanying spectral shifts.	Trehalose	187-196	myoglobin	Physeter catodon	172-181
9202465-5	1997	Experiments performed with an msn2/msn4 double mutant proved that the transcriptional induction of the genes encoding glycogen synthase (GSY2) and trehalose-6-phosphate synthase (TPS1) was needed for the small increase in glycogen and trehalose upon exposure to a mild heat stress and salt shock.	Trehalose	147-156	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	30-34
9202465-5	1997	Experiments performed with an msn2/msn4 double mutant proved that the transcriptional induction of the genes encoding glycogen synthase (GSY2) and trehalose-6-phosphate synthase (TPS1) was needed for the small increase in glycogen and trehalose upon exposure to a mild heat stress and salt shock.	Trehalose	147-156	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	35-39
9202465-5	1997	Experiments performed with an msn2/msn4 double mutant proved that the transcriptional induction of the genes encoding glycogen synthase (GSY2) and trehalose-6-phosphate synthase (TPS1) was needed for the small increase in glycogen and trehalose upon exposure to a mild heat stress and salt shock.	Trehalose	147-156	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	179-183
9302019-3	1997	Genetic approaches to determine the specific role of trehalose in heat-induced thermotolerance in Saccharomyces cerevisiae have been hampered by the finding that deletion of TPS1, the gene encoding trehalose-6-phosphate synthase, causes a variety of pleiotropic effects, including inability to grow on glucose-containing media.	Trehalose	53-62	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	174-178
9302019-5	1997	We show that tps1 mutants have a serious defect in heat shock-induced acquisition of thermotolerance if conditioned at highly elevated temperatures (40-42.5 degrees C), which, in wild-type cells, prevent hsp but not trehalose synthesis.	Trehalose	216-225	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	13-17
9302019-6	1997	In contrast, hsp synthesis appears to become particularly important under conditions in which trehalose synthesis is either absent (in tps1 mutant strains) or not fully induced (conditioning at moderately elevated temperatures, i.e. 35 degrees C).	Trehalose	94-103	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	135-139
9302019-8	1997	Unconditioned pka1 cells had low levels of trehalose but a high basal level of thermotolerance.	Trehalose	43-52	cAMP-dependent protein kinase catalytic subunit TPK1	Saccharomyces cerevisiae S288C	14-18
9302019-9	1997	It was found that pka1 mutant cells, contrary to wild-type cells, accumulated large amounts of trehalose, even during a 50 degrees C treatment.	Trehalose	95-104	cAMP-dependent protein kinase catalytic subunit TPK1	Saccharomyces cerevisiae S288C	18-22
9302019-10	1997	pka1 tps1 double mutants lacked this ability and showed reduced intrinsic thermotolerance, indicating a particularly important role for trehalose synthesis, which takes place during the challenging heat shock.	Trehalose	136-145	cAMP-dependent protein kinase catalytic subunit TPK1	Saccharomyces cerevisiae S288C	0-4
9302019-10	1997	pka1 tps1 double mutants lacked this ability and showed reduced intrinsic thermotolerance, indicating a particularly important role for trehalose synthesis, which takes place during the challenging heat shock.	Trehalose	136-145	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	5-9
9188045-8	1997	Covalent dimerization was almost totally suppressed by incorporation into a glassy matrix of trehalose, which both minimizes molecular mobility and physically separates the insulin molecules.	Trehalose	93-102	insulin	Homo sapiens	173-180
9194697-1	1997	Synthesis of trehalose in the yeast Saccharomyces cerevisiae is catalysed by the trehalose-6-phosphate (Tre6P) synthase/phosphatase complex, which is composed of at least three different subunits encoded by the genes TPS1, TPS2, and TSL1.	Trehalose	13-22	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	217-221
9194697-1	1997	Synthesis of trehalose in the yeast Saccharomyces cerevisiae is catalysed by the trehalose-6-phosphate (Tre6P) synthase/phosphatase complex, which is composed of at least three different subunits encoded by the genes TPS1, TPS2, and TSL1.	Trehalose	13-22	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	223-227
9194697-1	1997	Synthesis of trehalose in the yeast Saccharomyces cerevisiae is catalysed by the trehalose-6-phosphate (Tre6P) synthase/phosphatase complex, which is composed of at least three different subunits encoded by the genes TPS1, TPS2, and TSL1.	Trehalose	13-22	trehalose 6-phosphate synthase/phosphatase complex subunit	Saccharomyces cerevisiae S288C	233-237
9194697-2	1997	Previous studies indicated that Tps1 and Tps2 carry the catalytic activities of trehalose synthesis, namely Tre6P synthase (Tps1) and Tre6P phosphatase (Tps2), while TsI1 was suggested to have regulatory functions.	Trehalose	80-89	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	32-36
9194697-2	1997	Previous studies indicated that Tps1 and Tps2 carry the catalytic activities of trehalose synthesis, namely Tre6P synthase (Tps1) and Tre6P phosphatase (Tps2), while TsI1 was suggested to have regulatory functions.	Trehalose	80-89	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	41-45
9194697-2	1997	Previous studies indicated that Tps1 and Tps2 carry the catalytic activities of trehalose synthesis, namely Tre6P synthase (Tps1) and Tre6P phosphatase (Tps2), while TsI1 was suggested to have regulatory functions.	Trehalose	80-89	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	124-128
9194697-2	1997	Previous studies indicated that Tps1 and Tps2 carry the catalytic activities of trehalose synthesis, namely Tre6P synthase (Tps1) and Tre6P phosphatase (Tps2), while TsI1 was suggested to have regulatory functions.	Trehalose	80-89	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	153-157
9133641-3	1997	Using three different methods for trehalose determination, we observed trehalose accumulation in ggs1/tps1delta, tps2delta and tsl1delta mutants, and in the double mutants ggs1/tps1delta/tps2delta and also in ggs1/tps1delta deleted mutants suppressed for growth on glucose.	Trehalose	71-80	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	97-101
8922592-4	1996	[14C]Glc1-Man9-GlcNAc2 was found to be approximately sevenfold more rapidly hydrolyzed than the [14C]Glc2- and [14C]Glc3-homologues.	Trehalose	101-105	mannosidase alpha class 1A member 1	Homo sapiens	10-14
9008394-0	1997	Inhibition of trehalase activity enhances trehalose accumulation in transgenic plants.	Trehalose	42-51	probable trehalase	Nicotiana tabacum	14-23
9008394-3	1997	Plant trehalase activity was shown to affect the accumulation of trehalose in these plants.	Trehalose	65-74	probable trehalase	Nicotiana tabacum	6-15
9008394-4	1997	An increase in trehalose accumulation, up to 0.41 and 4.04 mg g-1 fresh weight in tobacco leaves and potato micro-tubers, respectively, was noted when the potent trehalase inhibitor validamycin A was added to in vitro plants and to hydroponically grown greenhouse plants.	Trehalose	15-24	probable trehalase	Nicotiana tabacum	162-171
8913738-8	1996	The same effect was seen in the tps1 (trehalose-6-phosphate synthase) hsp104 double mutant, suggesting that the extreme heat shock sensitivity was due mainly to a lack of trehalose rather than to the presence of trehalose-6-phosphate.	Trehalose	38-47	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	32-36
8913738-8	1996	The same effect was seen in the tps1 (trehalose-6-phosphate synthase) hsp104 double mutant, suggesting that the extreme heat shock sensitivity was due mainly to a lack of trehalose rather than to the presence of trehalose-6-phosphate.	Trehalose	38-47	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	70-76
9032112-8	1997	Grafts from islets cryopreserved with trehalose contained 14-fold more insulin than grafts from islets cryopreserved without trehalose.	Trehalose	38-47	insulin	Homo sapiens	71-78
9032112-11	1997	After transplantation in nude mice, there was a 15-fold increase in insulin content of grafts from ICCs cryopreserved with trehalose compared with ICCs cryopreserved without trehalose.	Trehalose	123-132	insulin	Homo sapiens	68-75
8987868-1	1996	The genes encoding for trehalose-producing enzymes, a glycosyl-trehalose-producing enzyme (glycosyltransferase) and a gylcosyl-trehalose-hydrolyzing enzyme (alpha-amylase), from Sulfolobus solfataricus KM1 were cloned and expressed in E. coli.	Trehalose	23-32	glycoside hydrolase family 57 protein	Saccharolobus solfataricus	157-170
8647289-8	1996	Our results show that the vacuolar acid trehalase Ath1p is necessary for the phenotype of growth on trehalose, i.e. trehalose utilization, in contrast to cytosolic neutral trehalase Nth1p which is necessary for intracellular degradation of trehalose.	Trehalose	116-125	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	50-55
8917076-0	1996	Analysis of DNA flanking the treA gene of Bacillus subtilis reveals genes encoding a putative specific enzyme IITre and a potential regulator of the trehalose operon.	Trehalose	149-158	trehalose-6-phosphate hydrolase	Bacillus subtilis subsp. subtilis str. 168	29-33
8856072-2	1996	Trehalase hydrolyzes trehalose (alpha-D-glycopyranosyl alpha-D-glucopyranoside) to give an equimolar mixture of alpha-D-glucose and, by inversion of configuration, beta-D-glucose.	Trehalose	21-30	trehalase	Sus scrofa	0-9
8856072-8	1996	These results support the hypothesis that the active center of trehalase may comprise two subsites, one for catalysis and one for recognition, that act separately on each of the glucose of the trehalose.	Trehalose	193-202	trehalase	Sus scrofa	63-72
8809751-1	1996	In the yeast Saccharomyces cerevisiae, trehalose-6-phosphate (tre-6-P) synthase encoded by GGS1/TPS1, is not only involved in the production of trehalose but also in restriction of sugar influx into glycolysis in an unknown fashion; it is therefore essential for growth on glucose or fructose.	Trehalose	39-48	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	91-95
8809751-1	1996	In the yeast Saccharomyces cerevisiae, trehalose-6-phosphate (tre-6-P) synthase encoded by GGS1/TPS1, is not only involved in the production of trehalose but also in restriction of sugar influx into glycolysis in an unknown fashion; it is therefore essential for growth on glucose or fructose.	Trehalose	39-48	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	96-100
8809779-4	1996	TPS2 and otsB each specify a trehalose-6-phosphate phosphatase, an enzyme that is necessary for trehalose synthesis.	Trehalose	29-38	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	0-4
8647289-0	1996	Deletion of the ATH1 gene in Saccharomyces cerevisiae prevents growth on trehalose.	Trehalose	73-82	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	16-20
8647289-2	1996	While it is generally accepted that the cytosolic neutral trehalase (encoded by the NTH1 gene) is responsible for trehalose hydrolysis in intact cells, very little is known about a role of the vacuolar acid trehalase and the product of the recently described neutral trehalase gene YBRO106 (NTH2).	Trehalose	114-123	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	84-88
8647289-6	1996	Experiments with diploid strains heterozygous for delta ath1 show a gene dosage effect for the ATH1 gene for growth on trehalose.	Trehalose	119-128	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	56-60
8647289-6	1996	Experiments with diploid strains heterozygous for delta ath1 show a gene dosage effect for the ATH1 gene for growth on trehalose.	Trehalose	119-128	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	95-99
7599147-6	1995	The inhibition of trehalase by trehazolin was competitive with respect to trehalose.	Trehalose	74-83	trehalase	Bombyx mori	18-27
8647289-8	1996	Our results show that the vacuolar acid trehalase Ath1p is necessary for the phenotype of growth on trehalose, i.e. trehalose utilization, in contrast to cytosolic neutral trehalase Nth1p which is necessary for intracellular degradation of trehalose.	Trehalose	100-109	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	50-55
8647289-8	1996	Our results show that the vacuolar acid trehalase Ath1p is necessary for the phenotype of growth on trehalose, i.e. trehalose utilization, in contrast to cytosolic neutral trehalase Nth1p which is necessary for intracellular degradation of trehalose.	Trehalose	116-125	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	50-55
8706810-7	1996	Trehalose is hydrolysed by trehalase (E.C.	Trehalose	0-9	trehalase	Homo sapiens	27-36
8549775-1	1995	The CIF1 gene (also called GGS1/TPS1) encodes a protein of the trehalose synthase complex that affects trehalose accumulation and general glucose sensing by Saccharomyces cerevisiae cells.	Trehalose	63-72	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	4-8
8549775-1	1995	The CIF1 gene (also called GGS1/TPS1) encodes a protein of the trehalose synthase complex that affects trehalose accumulation and general glucose sensing by Saccharomyces cerevisiae cells.	Trehalose	63-72	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	27-31
8549775-1	1995	The CIF1 gene (also called GGS1/TPS1) encodes a protein of the trehalose synthase complex that affects trehalose accumulation and general glucose sensing by Saccharomyces cerevisiae cells.	Trehalose	63-72	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	32-36
8549775-2	1995	There is considerable debate as to whether CIF1-dependent trehalose accumulation is a determinant in heat shock-acquired thermotolerance.	Trehalose	58-67	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	43-47
8633854-4	1996	The delta ath1 strain accumulated greater levels of cellular trehalose and grew to a higher cell density than the isogenic wild-type strain.	Trehalose	61-70	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	10-14
8633854-5	1996	In addition, the elevated levels of trehalose in the delta ath1 strain correlated with increased tolerance to dehydration, freezing, and toxic levels of ethanol.	Trehalose	36-45	alpha,alpha-trehalase ATH1	Saccharomyces cerevisiae S288C	59-63
27281156-4	1996	The alpha-amylase catalyzed the hydrolysis of glycosyltrehaloses to trehalose.	Trehalose	54-63	glycoside hydrolase family 57 protein	Saccharolobus solfataricus	4-17
27281156-5	1996	Analysis of the reaction products, kinetic parameters, and experimental findings using (3)H-labeIed substrates indicated that the alpha-amylase hydrolyzed only the alpha-1,4 glucosidic linkage adjacent to the trehalose unit of the glycosyltrehaloses.	Trehalose	209-218	glycoside hydrolase family 57 protein	Saccharolobus solfataricus	130-143
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	Trehalose	276-285	alpha-glucoside permease	Saccharomyces cerevisiae S288C	13-18
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	Trehalose	276-285	alpha-glucoside permease	Saccharomyces cerevisiae S288C	136-141
7551024-6	1995	Trehalose accumulation, a typical feature of cells entering the stationary phase G0, was very short-lived in the hex2 mutant under the same conditions.	Trehalose	0-9	protein phosphatase regulator REG1	Saccharomyces cerevisiae S288C	113-117
7788713-2	1995	Mutants defective in GGS1/TPS1 have been isolated repeatedly and they showed variable pleiotropic phenotypes, in particular with respect to trehalose content, ability to grow on fermentable sugars, glucose-induced signaling and sporulation capacity.	Trehalose	140-149	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	21-25
7788713-2	1995	Mutants defective in GGS1/TPS1 have been isolated repeatedly and they showed variable pleiotropic phenotypes, in particular with respect to trehalose content, ability to grow on fermentable sugars, glucose-induced signaling and sporulation capacity.	Trehalose	140-149	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	26-30
7788713-13	1995	We also show that the GGS1/TPS1 gene product is not only required for the transition from respirative to fermentative metabolism but continuously during logarithmic growth on glucose, in spite of the absence of trehalose under such conditions.	Trehalose	211-220	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	22-26
7988695-0	1994	Accumulation of trehalose in Saccharomyces cerevisiae growing on maltose is dependent on the TPS1 gene encoding the UDPglucose-linked trehalose synthase.	Trehalose	16-25	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	93-97
8646336-2	1995	Trehalose has many or possibly all of the properties required for this purpose, including solubilization of hemoglobin to a very high concentration, lack of toxicity, slowing of oxidation to the non-oxygen binding methemoglobin, stability at room temperature and above, and ease of transport.	Trehalose	0-9	hemoglobin subunit gamma 2	Homo sapiens	214-227
7988695-3	1994	However, this accumulation was completely prevented by deletion of the TPS1 gene coding for the catalytic subunit of the UDPglucose-linked trehalose-6-phosphate synthase, indicating that no alternative pathway for trehalose synthesis exists in yeast.	Trehalose	139-148	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	71-75
8243467-9	1993	In the presence of Glc, dGlc6P reaches a plateau after 1 h or 2 h of incubation while the quantities of trehalose (Glc-Glc), dGlc-dGlc, dGlc-Glc, which are small at 1 h, rapidly increase with time.	Trehalose	104-113	beta glucuronidase	Drosophila melanogaster	19-22
7882422-0	1994	The byp1-3 allele of the Saccharomyces cerevisiae GGS1/TPS1 gene and its multi-copy suppressor tRNA(GLN) (CAG): Ggs1/Tps1 protein levels restraining growth on fermentable sugars and trehalose accumulation.	Trehalose	182-191	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	4-8
7882422-0	1994	The byp1-3 allele of the Saccharomyces cerevisiae GGS1/TPS1 gene and its multi-copy suppressor tRNA(GLN) (CAG): Ggs1/Tps1 protein levels restraining growth on fermentable sugars and trehalose accumulation.	Trehalose	182-191	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	50-54
7882422-0	1994	The byp1-3 allele of the Saccharomyces cerevisiae GGS1/TPS1 gene and its multi-copy suppressor tRNA(GLN) (CAG): Ggs1/Tps1 protein levels restraining growth on fermentable sugars and trehalose accumulation.	Trehalose	182-191	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	55-59
7882422-0	1994	The byp1-3 allele of the Saccharomyces cerevisiae GGS1/TPS1 gene and its multi-copy suppressor tRNA(GLN) (CAG): Ggs1/Tps1 protein levels restraining growth on fermentable sugars and trehalose accumulation.	Trehalose	182-191	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	112-116
7882422-0	1994	The byp1-3 allele of the Saccharomyces cerevisiae GGS1/TPS1 gene and its multi-copy suppressor tRNA(GLN) (CAG): Ggs1/Tps1 protein levels restraining growth on fermentable sugars and trehalose accumulation.	Trehalose	182-191	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	117-121
7882422-8	1994	We also show a correlation between the level of Ggs1/Tps1, the ability to accumulate trehalose in stationary phase and the ability to grow on fermentable sugars.	Trehalose	85-94	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	48-52
7882422-8	1994	We also show a correlation between the level of Ggs1/Tps1, the ability to accumulate trehalose in stationary phase and the ability to grow on fermentable sugars.	Trehalose	85-94	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	53-57
8021171-8	1994	The TPS1 gene from S. cerevisiae could also restore trehalose synthesis in S. pombe tps1 mutants.	Trehalose	52-61	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	4-8
8021171-8	1994	The TPS1 gene from S. cerevisiae could also restore trehalose synthesis in S. pombe tps1 mutants.	Trehalose	52-61	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	84-88
8066119-4	1994	The 25% trehalose/NaCl gave higher fluorescence and phosphorescence quantum yields from both I-1 and BPDE-dG in contrast to the 1% alpha-CD/NaCl matrix.	Trehalose	8-17	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	93-96
8187889-6	1994	A mutant deficient in ubiquitin-conjugating genes, ubc4ubc5, shows during exponential growth a low trehalose concentration, but a high thermotolerance, in contrast to wild-type cells.	Trehalose	99-108	E2 ubiquitin-conjugating protein UBC4	Saccharomyces cerevisiae S288C	51-59
8306984-6	1994	Inactivation of either TPS1 or TPS2, encoding subunits of the trehalose-6-phosphate synthase/phosphatase complex, caused an inability to accumulate trehalose upon a mild heat-shock or upon initiation of the stationary phase and significantly reduced the levels of heat-induced and stationary-phase-induced thermotolerance.	Trehalose	62-71	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	23-27
8306984-6	1994	Inactivation of either TPS1 or TPS2, encoding subunits of the trehalose-6-phosphate synthase/phosphatase complex, caused an inability to accumulate trehalose upon a mild heat-shock or upon initiation of the stationary phase and significantly reduced the levels of heat-induced and stationary-phase-induced thermotolerance.	Trehalose	62-71	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	31-35
8306984-7	1994	Deletion of NTH1, the gene coding for the neutral trehalase, resulted in a defect in trehalose mobilization during recovery from a heat shock which was paralleled by an abnormally slow decrease of thermotolerance.	Trehalose	85-94	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	12-16
8148003-0	1994	Uncoupling by trehalose of Ca2+ transport and ATP hydrolysis by the plasma membrane (Ca2+ + Mg2+) ATPase of kidney tubules.	Trehalose	14-23	dynein axonemal heavy chain 8	Homo sapiens	98-104
8148003-3	1994	In the presence of 600 mM trehalose, Ca2+ uptake was almost completely inhibited, but the Ca(2+)-stimulated ATPase activity was unaffected; thus trehalose uncouples the Ca2+ transport from the ATPase activity.	Trehalose	26-35	dynein axonemal heavy chain 8	Homo sapiens	193-199
8148003-3	1994	In the presence of 600 mM trehalose, Ca2+ uptake was almost completely inhibited, but the Ca(2+)-stimulated ATPase activity was unaffected; thus trehalose uncouples the Ca2+ transport from the ATPase activity.	Trehalose	145-154	dynein axonemal heavy chain 8	Homo sapiens	193-199
8000532-0	1994	Concomitant appearance of intrinsic thermotolerance and storage of trehalose in Saccharomyces cerevisiae during early respiratory phase of batch-culture is CIF1-dependent.	Trehalose	67-76	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	156-160
8070577-0	1994	Heat-shock response in a yeast tps1 mutant deficient in trehalose synthesis.	Trehalose	56-65	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	31-35
7982561-4	1994	In general, Adh genotypes with higher ADH activity exhibit a twofold difference in relative carbon flux from malate into lactate and alanine vs. alpha,alpha-trehalose compared to low ADH activity genotypes.	Trehalose	145-166	Alcohol dehydrogenase	Drosophila melanogaster	12-15
7982561-4	1994	In general, Adh genotypes with higher ADH activity exhibit a twofold difference in relative carbon flux from malate into lactate and alanine vs. alpha,alpha-trehalose compared to low ADH activity genotypes.	Trehalose	145-166	Alcohol dehydrogenase	Drosophila melanogaster	38-41
8031833-5	1994	Our results directly implicate isoform PII of hexokinase and the minor isoform of phosphoglucomutase in the pathway of trehalose formation during heat-shock.	Trehalose	119-128	hexokinase	Saccharomyces cerevisiae S288C	46-56
8161500-1	1994	By suspending bovine rhodopsin in trehalose-water glass films, it is possible to trap photostates in the light-activation process.	Trehalose	34-43	rhodopsin	Bos taurus	21-30
8087890-6	1994	In a CIF1 background, cells carrying the mutation SCI2-1 accumulated trehalose during the logarithmic phase of growth and hyperaccumulated it during the stationary phase.	Trehalose	69-78	hexokinase 2	Saccharomyces cerevisiae S288C	50-54
8223613-8	1993	Disruption of GGS1 in K. lactis caused the same pleiotropic phenotype as in S. cerevisiae, i.e. inability to grow on glucose or fructose and strongly reduced trehalose content.	Trehalose	158-167	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	14-18
8363601-0	1993	A small influence of HSP90 levels on the trehalose and heat shock element inductions of the yeast heat shock response.	Trehalose	41-50	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	21-26
8363601-3	1993	Recently the trehalose induction was shown to be regulated by levels of HSP70 and, to a lesser extent, HSP104.	Trehalose	13-22	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	103-109
8363601-6	1993	The results show HSP90 levels having a small negative influence over the heat inductions of trehalose and the heat shock element, a minor effect compared with the major regulation exerted by HSP70.	Trehalose	92-101	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	17-22
8467996-3	1993	The TPS1 gene was able to restore both osmotolerance and trehalose accumulation during salt stress in an Escherichia coli strain mutated in the otsA gene encoding trehalose-6-phosphate synthase.	Trehalose	57-66	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	4-8
1834481-9	1991	Trehalose, glucose-6-phosphate, UDP-glucose, and ATP, were all found to increase during the 40 min heat treatment at 39 degrees C. Since this also occurs in a mutant lacking the heat shock-induced protein HSP104 (delta hsp104), this protein cannot be involved in the accumulation of trehalose under these heat shock conditions.	Trehalose	283-292	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	205-211
8467527-10	1993	However, both the ggs1 delta and the ggs1 delta, hk2 delta mutant lack detectable trehalose and trehalose-6-phosphate synthase activity.	Trehalose	82-91	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	18-22
8467527-10	1993	However, both the ggs1 delta and the ggs1 delta, hk2 delta mutant lack detectable trehalose and trehalose-6-phosphate synthase activity.	Trehalose	82-91	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	37-41
8467527-11	1993	Trehalose is undetectable even in ggs1 delta strains with strongly reduced activity of protein kinase A which normally causes a very high trehalose content.	Trehalose	0-9	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	34-38
8467527-11	1993	Trehalose is undetectable even in ggs1 delta strains with strongly reduced activity of protein kinase A which normally causes a very high trehalose content.	Trehalose	138-147	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	34-38
1834481-10	1991	However, mutant delta hsp104, in contrast to the parental wild-type, was sensitive towards a 20 min incubation at 50 degrees C. Since this mutant also accumulated normal levels of trehalose, we conclude that HSP104 function, and not towards a 20 min incubation at 50 degrees C. Since this mutant also accumulated normal levels of trehalose, we conclude that HSP104 function, and not the accumulation of trehalose, protects S. cerevisiae from the damage caused by a 50 degrees C treatment.	Trehalose	180-189	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	22-28
1834481-10	1991	However, mutant delta hsp104, in contrast to the parental wild-type, was sensitive towards a 20 min incubation at 50 degrees C. Since this mutant also accumulated normal levels of trehalose, we conclude that HSP104 function, and not towards a 20 min incubation at 50 degrees C. Since this mutant also accumulated normal levels of trehalose, we conclude that HSP104 function, and not the accumulation of trehalose, protects S. cerevisiae from the damage caused by a 50 degrees C treatment.	Trehalose	330-339	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	22-28
1834481-10	1991	However, mutant delta hsp104, in contrast to the parental wild-type, was sensitive towards a 20 min incubation at 50 degrees C. Since this mutant also accumulated normal levels of trehalose, we conclude that HSP104 function, and not towards a 20 min incubation at 50 degrees C. Since this mutant also accumulated normal levels of trehalose, we conclude that HSP104 function, and not the accumulation of trehalose, protects S. cerevisiae from the damage caused by a 50 degrees C treatment.	Trehalose	330-339	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	22-28
1935176-0	1991	Effect of Ca2+ on the cryoprotective action of trehalose.	Trehalose	47-56	carbonic anhydrase 2	Homo sapiens	10-13
1935176-2	1991	Ca2+ inhibits the cryoprotection achieved by trehalose to a greater extent than other sugars such as galactose, sucrose, and fructose.	Trehalose	45-54	carbonic anhydrase 2	Homo sapiens	0-3
1935176-3	1991	The cryoprotection by trehalose is also dependent on the Ca2+ concentration in the inside solution of the vesicle, even in the absence of external Ca2+.	Trehalose	22-31	carbonic anhydrase 2	Homo sapiens	57-60
33818826-5	2021	Carbohydrates including glucose, trehalose, and glycogen were decreased and increased in the hemolymph and tissues of lgl and melatonin-treated lgl flies, respectively.	Trehalose	33-42	lethal (2) giant larvae	Drosophila melanogaster	118-121
1699114-0	1990	Induction of interferons (IFNs) and tumor necrosis factor (TNF) in mice by a novel glycolipid trehalose 2,3,6"-trimycolate from Rhodococcus aurantiacus (Gordona aurantiaca).	Trehalose	94-103	tumor necrosis factor	Mus musculus	36-57
1699114-0	1990	Induction of interferons (IFNs) and tumor necrosis factor (TNF) in mice by a novel glycolipid trehalose 2,3,6"-trimycolate from Rhodococcus aurantiacus (Gordona aurantiaca).	Trehalose	94-103	tumor necrosis factor	Mus musculus	59-62
33786994-4	2021	Both organisms share identical pathway for trehalose biosynthesis (the TPS/TPP pathway), while a high degree of homology in their trehalose hydrolysis capacity (trehalase activities) has also been demonstrated.	Trehalose	130-139	trehalase	Homo sapiens	161-170
33768618-0	2021	The effect of trehalose, antioxidants, and acetate buffer concentration on oxytocin stability.	Trehalose	14-23	oxytocin/neurophysin I prepropeptide	Homo sapiens	75-83
33799517-0	2021	Trehalose Restrains the Fibril Load towards alpha-Lactalbumin Aggregation and Halts Fibrillation in a Concentration-Dependent Manner.	Trehalose	0-9	lactalbumin alpha	Homo sapiens	44-61
33768618-3	2021	The aim of this study was to investigate the effect of trehalose and select antioxidants (uric acid, butylated hydroxytoluene, and l-ascorbic acid) on oxytocin stability in solution.	Trehalose	55-64	oxytocin/neurophysin I prepropeptide	Homo sapiens	151-159
33232441-9	2021	Excess D-glucose is phosphorylated enters the trehalose pathway resulting in glucose recycling and energy dissipation, accumulation of trehalose-6-phosphate which inhibits the hexokinase activity, and release of trehalose into the medium.	Trehalose	46-55	hexokinase	Saccharomyces cerevisiae S288C	176-186
33232441-9	2021	Excess D-glucose is phosphorylated enters the trehalose pathway resulting in glucose recycling and energy dissipation, accumulation of trehalose-6-phosphate which inhibits the hexokinase activity, and release of trehalose into the medium.	Trehalose	135-144	hexokinase	Saccharomyces cerevisiae S288C	176-186
34971589-0	2022	Trehalose protects against cisplatin-induced cochlear hair cell damage by activating TFEB-mediated autophagy.	Trehalose	0-9	transcription factor EB	Mus musculus	85-89
14558821-8	2003	On the other hand, from the (13)C-T(1) measurements for trehalose, the T(1) values of the C-3 (C-3") and C-6" (C-6) are found to change remarkably by addition of UFA.	Trehalose	56-65	complement C3	Homo sapiens	90-93
14558821-8	2003	On the other hand, from the (13)C-T(1) measurements for trehalose, the T(1) values of the C-3 (C-3") and C-6" (C-6) are found to change remarkably by addition of UFA.	Trehalose	56-65	complement C3	Homo sapiens	95-98
14558821-8	2003	On the other hand, from the (13)C-T(1) measurements for trehalose, the T(1) values of the C-3 (C-3") and C-6" (C-6) are found to change remarkably by addition of UFA.	Trehalose	56-65	complement C6	Homo sapiens	105-114
8076599-3	1994	One such mutation was further characterized and the affected gene was shown to be identical to TPS2 which encodes trehalose phosphate phosphatase, an enzyme catalysing the second step in trehalose biosynthesis.	Trehalose	114-123	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	95-99
34927547-5	2022	The increase in the device"s surface area and the incorporation of trehalose in the loaded lyophilized mix increased the IL-2 release rate with drug release proceeding via typical zero-order release kinetics.	Trehalose	67-76	interleukin 2	Mus musculus	121-125
23997112-7	2013	Stimulation of mammalian target of rapamycin (mTOR)-dependent signaling protected against cell death induced by paraquat, whereas MPP+-induced toxicity was enhanced by wortmannin, a phosphoinositide 3-kinase class III inhibitor, rapamycin, and trehalose, an mTOR-independent autophagy activator.	Trehalose	244-253	mechanistic target of rapamycin kinase	Homo sapiens	15-44
23997112-7	2013	Stimulation of mammalian target of rapamycin (mTOR)-dependent signaling protected against cell death induced by paraquat, whereas MPP+-induced toxicity was enhanced by wortmannin, a phosphoinositide 3-kinase class III inhibitor, rapamycin, and trehalose, an mTOR-independent autophagy activator.	Trehalose	244-253	mechanistic target of rapamycin kinase	Homo sapiens	46-50
34971589-9	2022	Mechanistically, we showed that the effect of trehalose was attributed to increased nuclear translocation of transcription factor EB (TFEB), and this effect could be mimicked by TFEB overexpression and inhibited by TFEB gene silencing or treatment with cyclosporin A (CsA), a calcineurin inhibitor.	Trehalose	46-55	transcription factor EB	Mus musculus	134-138
34971589-9	2022	Mechanistically, we showed that the effect of trehalose was attributed to increased nuclear translocation of transcription factor EB (TFEB), and this effect could be mimicked by TFEB overexpression and inhibited by TFEB gene silencing or treatment with cyclosporin A (CsA), a calcineurin inhibitor.	Trehalose	46-55	transcription factor EB	Mus musculus	178-182
34971589-9	2022	Mechanistically, we showed that the effect of trehalose was attributed to increased nuclear translocation of transcription factor EB (TFEB), and this effect could be mimicked by TFEB overexpression and inhibited by TFEB gene silencing or treatment with cyclosporin A (CsA), a calcineurin inhibitor.	Trehalose	46-55	transcription factor EB	Mus musculus	215-219
34970418-0	2021	Trehalose Ameliorates Diabetic Cardiomyopathy: Role of the PK2/PKR Pathway.	Trehalose	0-9	prokineticin 2	Mus musculus	59-62
34970418-0	2021	Trehalose Ameliorates Diabetic Cardiomyopathy: Role of the PK2/PKR Pathway.	Trehalose	0-9	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	63-66
34669246-2	2021	Trehalose might antagonize dAGEs induced neurotoxicity via GSK3beta-TFEB signaling.	Trehalose	0-9	glycogen synthase kinase 3 alpha	Mus musculus	59-67
34956146-5	2021	Among eight mono- and disaccharides tested, all were potent inducers of avian beta-defensin 9 (AvBD9) gene (p<0.05), but only galactose, trehalose, and lactose obviously upregulated cathelicidin-B1 (CATHB1) gene expression.	Trehalose	137-146	cathelicidin B1	Gallus gallus	182-197
34956146-5	2021	Among eight mono- and disaccharides tested, all were potent inducers of avian beta-defensin 9 (AvBD9) gene (p<0.05), but only galactose, trehalose, and lactose obviously upregulated cathelicidin-B1 (CATHB1) gene expression.	Trehalose	137-146	cathelicidin B1	Gallus gallus	199-205
34956146-7	2021	Moreover, all sugars exhibited a strong synergy with butyrate in enhancing AvBD9 expression, while only galactose, trehalose, and lactose were synergistic with butyrate in CATHB1 induction.	Trehalose	115-124	cathelicidin B1	Gallus gallus	172-178
34669246-8	2021	Trehalose elevated p-GSK3beta ser9, induced TFEB nuclear translocation, consequently reversed AGE-BSA induced tau phosphorylation in vitro.	Trehalose	0-9	glycogen synthase kinase 3 alpha	Mus musculus	21-29
34669246-8	2021	Trehalose elevated p-GSK3beta ser9, induced TFEB nuclear translocation, consequently reversed AGE-BSA induced tau phosphorylation in vitro.	Trehalose	0-9	transcription factor EB	Mus musculus	44-48
34948299-0	2021	Ionophore Ability of Carnosine and Its Trehalose Conjugate Assists Copper Signal in Triggering Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Activation In Vitro.	Trehalose	39-48	brain derived neurotrophic factor	Homo sapiens	95-128
34948299-0	2021	Ionophore Ability of Carnosine and Its Trehalose Conjugate Assists Copper Signal in Triggering Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Activation In Vitro.	Trehalose	39-48	vascular endothelial growth factor A	Homo sapiens	133-167
34907287-8	2021	Trehalose (an inducer of mTOR-independent autophagy) treatment significantly increased NET formation, whereas rapamycin (an mTOR-dependent autophagy inducer) did not increase NET release by neutrophils.	Trehalose	0-9	mechanistic target of rapamycin kinase	Mus musculus	25-29
34749031-8	2021	We found TFEB was highly activated with trehalose treatment.	Trehalose	40-49	transcription factor EB	Rattus norvegicus	9-13
34669246-10	2021	Trehalose could strongly reverse dAGEs-induced tau phosphorylation by potentiating TFEB nuclear translocation via inhibiting GSK-3beta.	Trehalose	0-9	transcription factor EB	Mus musculus	83-87
34669246-10	2021	Trehalose could strongly reverse dAGEs-induced tau phosphorylation by potentiating TFEB nuclear translocation via inhibiting GSK-3beta.	Trehalose	0-9	glycogen synthase kinase 3 alpha	Mus musculus	125-134
34669246-2	2021	Trehalose might antagonize dAGEs induced neurotoxicity via GSK3beta-TFEB signaling.	Trehalose	0-9	transcription factor EB	Mus musculus	68-72
34669246-7	2021	Trehalose upregulated p-GSK3beta ser9, TFEB and TRPML1, ADAM10, OST48, ERalpha and induced TFEB nuclear translocation in hippocampus, elevated IDE and ERbeta in cortex, while reduced p-tau ser396&404, CDK5, cathepsin B and GFAP in hippocampus.	Trehalose	0-9	glycogen synthase kinase 3 alpha	Mus musculus	24-32
34669246-7	2021	Trehalose upregulated p-GSK3beta ser9, TFEB and TRPML1, ADAM10, OST48, ERalpha and induced TFEB nuclear translocation in hippocampus, elevated IDE and ERbeta in cortex, while reduced p-tau ser396&404, CDK5, cathepsin B and GFAP in hippocampus.	Trehalose	0-9	transcription factor EB	Mus musculus	39-43
34669246-7	2021	Trehalose upregulated p-GSK3beta ser9, TFEB and TRPML1, ADAM10, OST48, ERalpha and induced TFEB nuclear translocation in hippocampus, elevated IDE and ERbeta in cortex, while reduced p-tau ser396&404, CDK5, cathepsin B and GFAP in hippocampus.	Trehalose	0-9	mucolipin 1	Mus musculus	48-54
34669246-7	2021	Trehalose upregulated p-GSK3beta ser9, TFEB and TRPML1, ADAM10, OST48, ERalpha and induced TFEB nuclear translocation in hippocampus, elevated IDE and ERbeta in cortex, while reduced p-tau ser396&404, CDK5, cathepsin B and GFAP in hippocampus.	Trehalose	0-9	a disintegrin and metallopeptidase domain 10	Mus musculus	56-62
34669246-7	2021	Trehalose upregulated p-GSK3beta ser9, TFEB and TRPML1, ADAM10, OST48, ERalpha and induced TFEB nuclear translocation in hippocampus, elevated IDE and ERbeta in cortex, while reduced p-tau ser396&404, CDK5, cathepsin B and GFAP in hippocampus.	Trehalose	0-9	estrogen receptor 1 (alpha)	Mus musculus	71-78
34669246-7	2021	Trehalose upregulated p-GSK3beta ser9, TFEB and TRPML1, ADAM10, OST48, ERalpha and induced TFEB nuclear translocation in hippocampus, elevated IDE and ERbeta in cortex, while reduced p-tau ser396&404, CDK5, cathepsin B and GFAP in hippocampus.	Trehalose	0-9	transcription factor EB	Mus musculus	91-95
34669246-7	2021	Trehalose upregulated p-GSK3beta ser9, TFEB and TRPML1, ADAM10, OST48, ERalpha and induced TFEB nuclear translocation in hippocampus, elevated IDE and ERbeta in cortex, while reduced p-tau ser396&404, CDK5, cathepsin B and GFAP in hippocampus.	Trehalose	0-9	insulin degrading enzyme	Mus musculus	143-146
34669246-7	2021	Trehalose upregulated p-GSK3beta ser9, TFEB and TRPML1, ADAM10, OST48, ERalpha and induced TFEB nuclear translocation in hippocampus, elevated IDE and ERbeta in cortex, while reduced p-tau ser396&404, CDK5, cathepsin B and GFAP in hippocampus.	Trehalose	0-9	estrogen receptor 1 (alpha)	Mus musculus	151-157
34669246-7	2021	Trehalose upregulated p-GSK3beta ser9, TFEB and TRPML1, ADAM10, OST48, ERalpha and induced TFEB nuclear translocation in hippocampus, elevated IDE and ERbeta in cortex, while reduced p-tau ser396&404, CDK5, cathepsin B and GFAP in hippocampus.	Trehalose	0-9	cyclin-dependent kinase 5	Mus musculus	201-205
34669246-7	2021	Trehalose upregulated p-GSK3beta ser9, TFEB and TRPML1, ADAM10, OST48, ERalpha and induced TFEB nuclear translocation in hippocampus, elevated IDE and ERbeta in cortex, while reduced p-tau ser396&404, CDK5, cathepsin B and GFAP in hippocampus.	Trehalose	0-9	cathepsin B	Mus musculus	207-218
34669246-7	2021	Trehalose upregulated p-GSK3beta ser9, TFEB and TRPML1, ADAM10, OST48, ERalpha and induced TFEB nuclear translocation in hippocampus, elevated IDE and ERbeta in cortex, while reduced p-tau ser396&404, CDK5, cathepsin B and GFAP in hippocampus.	Trehalose	0-9	glial fibrillary acidic protein	Mus musculus	223-227
33356857-6	2021	Ath1 was found to be located in the periplasm and was essential for growth on trehalose as sole carbon source, while Nth1 on the other hand was important for oxidative stress resistance, an observation which was consistent by the lower survival rate of the NTH1 deletion strain in human macrophages.	Trehalose	78-87	atonal bHLH transcription factor 1	Homo sapiens	0-4
34830305-4	2021	By genetically knocking down dSLC5A5 in flies, we found that systemic and circulating glucose and trehalose levels are significantly decreased, which correlates with an attenuation in glucose uptake in the enterocytes.	Trehalose	98-107	Sodium-dependent multivitamin transporter	Drosophila melanogaster	29-36
34830305-5	2021	Reciprocally, overexpression of dSLC5A5 significantly increases systemic and circulating glucose and trehalose levels and promotes glucose uptake in the enterocytes.	Trehalose	101-110	Sodium-dependent multivitamin transporter	Drosophila melanogaster	32-39
34494279-0	2021	Improving SIRT1 by trehalose supplementation reduces oxidative stress, inflammation, and histopathological scores in the kidney of aged rats.	Trehalose	19-28	sirtuin 1	Rattus norvegicus	10-15
34779585-12	2022	In comparison with G5B0.00, supplementation of 1 mM boron with and without trehalose had significantly lower expression of GCLC.	Trehalose	75-84	glutamate-cysteine ligase catalytic subunit	Homo sapiens	123-127
34077617-7	2021	The pathway-driven analysis identified ZmTPS9, which encodes a trehalose-6-phosphate synthase in the trehalose pathway, as the causal gene for the QTL qSTA4-2, which was detected by all three statistical analyses.	Trehalose	101-110	Sesquithujene synthase A	Zea mays	39-45
34077617-7	2021	The pathway-driven analysis identified ZmTPS9, which encodes a trehalose-6-phosphate synthase in the trehalose pathway, as the causal gene for the QTL qSTA4-2, which was detected by all three statistical analyses.	Trehalose	101-110	trehalose-6-phosphate synthase	Zea mays	63-93
34486131-0	2021	Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice.	Trehalose	0-9	transcription factor EB	Mus musculus	53-57
34486131-2	2021	Trehalose, a disaccharide, activates TFEB and protects against diet-induced nonalcoholic fatty liver disease in mice.	Trehalose	0-9	transcription factor EB	Mus musculus	37-41
34486131-3	2021	The aim of the present study was to investigate whether trehalose would reverse the impairment of TFEB induced by alcohol and protect against alcohol-induced liver injury.	Trehalose	56-65	transcription factor EB	Mus musculus	98-102
34486131-7	2021	Trehalose increased TFEB nuclear translocation, elevated levels of LC3-II and lysosomal proteins in mouse livers and cultured AML12 cells, confirming the activation of TFEB by trehalose.	Trehalose	0-9	transcription factor EB	Mus musculus	20-24
34486131-7	2021	Trehalose increased TFEB nuclear translocation, elevated levels of LC3-II and lysosomal proteins in mouse livers and cultured AML12 cells, confirming the activation of TFEB by trehalose.	Trehalose	176-185	transcription factor EB	Mus musculus	20-24
34486131-7	2021	Trehalose increased TFEB nuclear translocation, elevated levels of LC3-II and lysosomal proteins in mouse livers and cultured AML12 cells, confirming the activation of TFEB by trehalose.	Trehalose	176-185	transcription factor EB	Mus musculus	168-172
34358864-2	2021	In this note, we report a ReOCl3(SMe2)(OPPh3) catalyzed coupling reaction between beta-glycosyl thiols (1-thio sugars) and glycals for the preparation of 1,1"-alpha,beta-2-deoxy thioglycosides, which are glycomimetics of natural trehalose and 2-deoxy glycosides.	Trehalose	229-238	glycoprotein hormone subunit alpha 2	Homo sapiens	165-171
34494279-4	2021	In this study, we investigated the effects of trehalose on renal SIRT1 and kidney function in senescent rats.	Trehalose	46-55	sirtuin 1	Rattus norvegicus	65-70
34494279-7	2021	Trehalose supplementation increased the level of SIRT1, whereas alleviated the level of oxidative stress, inflammation, and histopathology scores in senescent tissues.	Trehalose	0-9	sirtuin 1	Rattus norvegicus	49-54
34494279-13	2021	This study showed that trehalose administration to aged rats had renoprotective effects through reducing oxidative stress and inflammation, which was mediated by SIRT1.	Trehalose	23-32	sirtuin 1	Rattus norvegicus	162-167
34685538-9	2021	Thus, trehalose as an inducer of mTOR-independent autophagy is effective at alleviating neuronal and behavioral disturbances accompanying experimental diabetes.	Trehalose	6-15	mechanistic target of rapamycin kinase	Mus musculus	33-37
34391081-0	2021	Methanol extract of Sedum oryzifolium and its constituent, trehalose, impede the invasiveness of oral squamous cell carcinoma cell lines via downregulation of Slug.	Trehalose	59-68	snail family transcriptional repressor 2	Homo sapiens	159-163
34391081-9	2021	Notably, treatment with trehalose, a sugar component of MESO, inhibited invasiveness and Slug expression in OSCC cells.	Trehalose	24-33	snail family transcriptional repressor 2	Homo sapiens	89-93
34391081-10	2021	CONCLUSION: Cumulatively, this study highlighted the beneficial role of MESO and trehalose in the inhibition of invasiveness of OSCC cells via suppression of Slug expression and suggested a new design for potential chemotherapeutic drugs against OSCC.	Trehalose	81-90	snail family transcriptional repressor 2	Homo sapiens	158-162
34685367-1	2021	We combined broad-band depolarized light scattering and infrared spectroscopies to study the properties of hydration water in a lysozyme-trehalose aqueous solution, where trehalose is present above the concentration threshold (30% in weight) relevant for biopreservation.	Trehalose	137-146	lysozyme	Homo sapiens	128-136
34564224-0	2021	Insulin-Like Peptide and FoxO Mediate the Trehalose Catabolism Enhancement during the Diapause Termination Period in the Chinese Oak Silkworm (Antheraea pernyi).	Trehalose	42-51	insulin-like peptide	Bombyx mori	0-20
34575099-2	2021	Trehalose has been validated to restore the impaired autophagy flux by boosting transcription factor EB (TFEB) nuclear translocation, but orally administrated trehalose can be greatly digested by intestinal trehalase before entering into brain.	Trehalose	0-9	transcription factor EB	Rattus norvegicus	105-109
34564224-0	2021	Insulin-Like Peptide and FoxO Mediate the Trehalose Catabolism Enhancement during the Diapause Termination Period in the Chinese Oak Silkworm (Antheraea pernyi).	Trehalose	42-51	fkhr	Bombyx mori	25-29
34564224-1	2021	In insects, trehalose accumulation is associated with the insulin/insulin-like growth factor signalling (IIS) pathway.	Trehalose	12-21	insulin	Bos taurus	58-65
34564224-1	2021	In insects, trehalose accumulation is associated with the insulin/insulin-like growth factor signalling (IIS) pathway.	Trehalose	12-21	insulin	Bos taurus	66-73
34564224-2	2021	However, whether insulin-like peptide is involved in the regulation of the trehalose metabolism during diapause termination remains largely unknown.	Trehalose	75-84	insulin-like peptide	Bombyx mori	17-37
34564224-3	2021	This study assessed whether insulin-like peptide (ApILP) enhances the trehalose catabolism in the pupae of Antheraeapernyi during their diapause termination process.	Trehalose	70-79	insulin-like peptide	Bombyx mori	28-48
34564224-5	2021	Moreover, treatment with bovine insulin increased the expression of trehalase 1A (ApTre-1A) and trehalase 2 (ApTre-2), as well as the activity of soluble and membrane-bound trehalase, resulting in a decline in trehalose levels in the haemolymph.	Trehalose	210-219	insulin	Bos taurus	32-39
34354165-3	2021	RNA interference (RNAi) of trehalose-6-phosphate synthase gene (ApTPS) decreased while RNAi of trehalase gene (ApTRE) increased the trehalose and glucose contents.	Trehalose	132-141	trehalase	Acyrthosiphon pisum	95-104
34578829-1	2021	Trehalose, a sugar from fungi, mimics starvation due to a block of glucose transport and induces Transcription Factor EB- mediated autophagy, likely supported by the upregulation of progranulin.	Trehalose	0-9	granulin	Mus musculus	182-193
34458560-7	2021	The results showed that 100  mM  trehalose significantly improved the proliferation potential of EECs, in which the cells could be serially passaged 14 times with continued normal GPX5 and AR marker gene expression in vitro.	Trehalose	33-42	epididymal secretory glutathione peroxidase	Ovis aries	180-184
34458560-7	2021	The results showed that 100  mM  trehalose significantly improved the proliferation potential of EECs, in which the cells could be serially passaged 14 times with continued normal GPX5 and AR marker gene expression in vitro.	Trehalose	33-42	androgen receptor	Ovis aries	189-191
34458560-9	2021	Moreover, the trehalose decreased ROS significantly ( P < 0.01  ) and increased CAT ( P < 0.01  ) and GSH-Px ( P < 0.05  ) activities significantly in EECs.	Trehalose	14-23	catalase	Ovis aries	80-83
34458560-10	2021	GPX5 mRNA and protein expression were also significantly upregulated in trehalose-treated EECs ( P < 0.05  and P < 0.01  respectively).	Trehalose	72-81	epididymal secretory glutathione peroxidase	Ovis aries	0-4
34458560-11	2021	Our study suggested that exogenous trehalose exhibited antioxidant activity through increasing the activities of CAT, GSH-Px, and the expression level of GPX5 and could be employed to maintain vitality of sheep EECs during long-term in vitro culture.	Trehalose	35-44	catalase	Ovis aries	113-116
34458560-11	2021	Our study suggested that exogenous trehalose exhibited antioxidant activity through increasing the activities of CAT, GSH-Px, and the expression level of GPX5 and could be employed to maintain vitality of sheep EECs during long-term in vitro culture.	Trehalose	35-44	epididymal secretory glutathione peroxidase	Ovis aries	154-158
34405311-4	2022	In this study, the effects of a glycine powder and a trehalose powder on human gingival fibroblasts (HGF) were investigated.	Trehalose	53-62	hepatocyte growth factor	Homo sapiens	101-104
34227851-6	2021	Results: Artificial tears containing SH with and without trehalose induce a complete autophagic flux, as indicated by an increase in the number of autophagosomes and autolysosomes, and the accumulation of the lipidated form of LC3 associated with complete autophagy.	Trehalose	57-66	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	227-230
34245722-6	2021	The study results indicated that GSH-2, 1 mM and trehalose- 100 mM concentrations reduced lipid peroxidase levels and increased total antioxidant activity, catalase, superoxide dismutase, and glutathione peroxidase in comparison to the control group (P <=0.05).	Trehalose	49-58	catalase	Meleagris gallopavo	156-164
34542745-1	2021	We studied the possibilities of inhibition of neurodegeneration in MPTP-induced model of Parkinson"s disease (PD) in C57Bl/6J mice and transgenic model of early PD stage (5-monthold B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J mice) by autophagy activation through mTOR-dependent and mTOR-independent pathways with rapamycin and trehalose, respectively.	Trehalose	317-326	mechanistic target of rapamycin kinase	Mus musculus	253-257
34259987-9	2021	In contrast, treatment with the autophagy inducer trehalose (Tre) restored phagocytosis, TNF-alpha and IL-6 secretion, and MHC-II expression in GEM-induced immune-inhibited macrophages.	Trehalose	50-59	tumor necrosis factor	Homo sapiens	89-98
34259987-9	2021	In contrast, treatment with the autophagy inducer trehalose (Tre) restored phagocytosis, TNF-alpha and IL-6 secretion, and MHC-II expression in GEM-induced immune-inhibited macrophages.	Trehalose	50-59	interleukin 6	Homo sapiens	103-107
34259987-9	2021	In contrast, treatment with the autophagy inducer trehalose (Tre) restored phagocytosis, TNF-alpha and IL-6 secretion, and MHC-II expression in GEM-induced immune-inhibited macrophages.	Trehalose	61-64	tumor necrosis factor	Homo sapiens	89-98
34259987-9	2021	In contrast, treatment with the autophagy inducer trehalose (Tre) restored phagocytosis, TNF-alpha and IL-6 secretion, and MHC-II expression in GEM-induced immune-inhibited macrophages.	Trehalose	61-64	interleukin 6	Homo sapiens	103-107
34197084-0	2021	Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of alpha-Synuclein-Induced Rat Model of Parkinson"s Disease.	Trehalose	27-36	synuclein alpha	Rattus norvegicus	88-103
34152451-12	2021	Deletion of URE2 reduces glycogen and trehalose production.	Trehalose	38-47	glutathione peroxidase	Saccharomyces cerevisiae S288C	12-16
34251339-6	2021	Intriguingly, animals with E2F-deficient fat body had a lower level of circulating trehalose and reduced storage of fat.	Trehalose	83-92	E2F transcription factor 1	Drosophila melanogaster	27-30
34336117-0	2021	Trehalose Augments Neuron Survival and Improves Recovery from Spinal Cord Injury via mTOR-Independent Activation of Autophagy.	Trehalose	0-9	mechanistic target of rapamycin kinase	Rattus norvegicus	85-89
34336117-3	2021	We administered trehalose, an mTOR-independent autophagy agonist, in SCI rats suffering from moderate compression injury to elucidate the relationship between autophagy and SCI and evaluate trehalose"s therapeutic potential.	Trehalose	16-25	mechanistic target of rapamycin kinase	Rattus norvegicus	30-34
34336117-8	2021	Trehalose promotes autophagosome recruitment via an mTOR-independent pathway, enhances autophagy flux in neurons, inhibits apoptosis via the intrinsic mitochondria-dependent pathway, reduces lesion cavity expansion, decreases neuron loss, and ultimately improves functional recovery following SCI (all p < 0.05).	Trehalose	0-9	mechanistic target of rapamycin kinase	Rattus norvegicus	52-56
34336117-10	2021	This study presents new evidence that autophagy plays a critical neuroprotective and neuroregenerative role in SCI, and that mTOR-independent activation of autophagy with trehalose leads to improved outcomes.	Trehalose	171-180	mechanistic target of rapamycin kinase	Rattus norvegicus	125-129
34206776-1	2021	The disaccharide trehalose was described as possessing relevant neuroprotective properties as an mTORC1-independent inducer of autophagy, with the ability to protect cellular membranes and denaturation, resulting from desiccation, and preventing the cellular accumulation of protein aggregates.	Trehalose	17-26	CREB regulated transcription coactivator 1	Mus musculus	97-103
34206776-2	2021	These properties make trehalose an interesting therapeutic candidate against proteinopathies such as Alzheimer"s disease (AD), which is characterized by deposits of aggregated amyloid-beta (Abeta) and hyperphosphorylated tau.	Trehalose	22-31	amyloid beta (A4) precursor protein	Mus musculus	190-195
34206776-4	2021	Trehalose treatment reduced secreted Abeta levels in a manner unrelated to its intracellular accumulation or its elimination through endocytosis or enzymatic degradation.	Trehalose	0-9	amyloid beta (A4) precursor protein	Mus musculus	37-42
34206776-6	2021	Instead, our results support that the neuroprotective effect of trehalose was mediated by a reduced colocalization of APP and BACE1 in the cell, and, therefore, a lower amyloidogenic processing of APP.	Trehalose	64-73	beta-site APP cleaving enzyme 1	Mus musculus	126-131
34065101-6	2021	NPc remained stable at 4  C for 28 days, and when freeze-dried with 0.1% w/v of trehalose, the aggregation was prevented.	Trehalose	80-89	NPC intracellular cholesterol transporter 1	Homo sapiens	0-3
34177153-6	2021	Higher gene expression and enzyme activities were exhibited by superoxide dismutase, catalase and peroxidase besides the gene expression of trehalose biosynthetic pathway enzymes.	Trehalose	140-149	peroxidase 1	Zea mays	98-108
34211593-0	2021	Synthesis of Disulfide-Bridging Trehalose Polymers for Antibody and Fab Conjugation Using a Bis-Sulfone ATRP Initiator.	Trehalose	32-41	FA complementation group B	Homo sapiens	68-71
34211593-8	2021	This work provides a new way to prepare polymer-antibody/Fab conjugates utilizing bis-sulfone end groups installed by atom transfer radical polymerization of the functionalized initiators and a way to stabilize these important molecules by conjugation to trehalose polymers.	Trehalose	255-264	FA complementation group B	Homo sapiens	57-60
35483619-3	2022	Here, we show that mixtures of the stabilizing excipients trehalose (Tre) and dextran (Dex), in combination with the shell-forming dispersion enhancer leucine (Leu), stabilize TNF-alpha siRNA-loaded LPNs during spray drying into nanocomposite microparticles, and result in DPI formulations with high aerosol performance.	Trehalose	58-67	tumor necrosis factor	Mus musculus	176-185
34719147-12	2021	Up to 1% of the population of the European part of the Russian Federation have the AA*TREH genotype (i.e. trehalose intolerance in phenotype), and up to 15% (GA*TREH genotype) have a reduced ability to absorb the disaccharide.	Trehalose	106-115	trehalase	Homo sapiens	86-90
35483619-3	2022	Here, we show that mixtures of the stabilizing excipients trehalose (Tre) and dextran (Dex), in combination with the shell-forming dispersion enhancer leucine (Leu), stabilize TNF-alpha siRNA-loaded LPNs during spray drying into nanocomposite microparticles, and result in DPI formulations with high aerosol performance.	Trehalose	69-72	tumor necrosis factor	Mus musculus	176-185
35483619-10	2022	Our results demonstrate that at optimal ratios, ternary excipient mixtures of Leu, Tre and Dex protect TNF-alpha siRNA-loaded LPNs during spray drying.	Trehalose	83-86	tumor necrosis factor	Mus musculus	103-112
35426201-1	2022	A robust strategy is reported to build perfectly monodiperse star polycations combining a trehalose-based cyclooligosaccharide (cyclotrehalan, CT) central core onto which oligoethyleneimine radial arms are installed.	Trehalose	90-99	steroidogenic acute regulatory protein	Homo sapiens	61-65
35613408-7	2022	Contrarily, promoting the autophagic degradation of RIG-I by trehalose treatment could alleviate IFN-I signaling pathway.	Trehalose	61-70	DExD/H-box helicase 58	Homo sapiens	52-57
35618982-5	2022	Trehalose significantly improved olfactory dysfunction and depressive-like behaviors and markedly reduced alpha-synuclein and p62 deposition in the brain.	Trehalose	0-9	synuclein, alpha	Mus musculus	106-121
35609863-2	2022	There are two ways to induce autophagy: through mTOR-dependent and mTOR-independent pathways (here, by means of rapamycin and trehalose, respectively).	Trehalose	126-135	mechanistic target of rapamycin kinase	Mus musculus	48-52
35609863-2	2022	There are two ways to induce autophagy: through mTOR-dependent and mTOR-independent pathways (here, by means of rapamycin and trehalose, respectively).	Trehalose	126-135	mechanistic target of rapamycin kinase	Mus musculus	67-71
35618982-5	2022	Trehalose significantly improved olfactory dysfunction and depressive-like behaviors and markedly reduced alpha-synuclein and p62 deposition in the brain.	Trehalose	0-9	nucleoporin 62	Mus musculus	126-129
35499968-6	2022	Additionally, trehalose improved the gene expressions and activities of alpha-amylase, starch-branching enzymes, total amylase, H+-ATPase, and Ca2+-ATPase, as well as soluble sugar, adenosine triphosphate, and adenosine diphosphate contents and energy charge in apples.	Trehalose	14-23	probable alpha-amylase 2	Malus domestica	72-85
35578066-0	2022	Protective effects of trehalose preconditioning on cardiac and coronary endothelial function through eNOS signaling pathway in a rat model of ischemia-reperfusion injury.	Trehalose	22-31	nitric oxide synthase 3	Rattus norvegicus	101-105
35578066-2	2022	Trehalose, a natural disaccharide, has been reported to ameliorate endothelial dysfunction during aging by activating endothelial nitric oxide synthase (eNOS); however, its role in I/R injury is unknown.	Trehalose	0-9	nitric oxide synthase 3	Rattus norvegicus	118-151
35578066-2	2022	Trehalose, a natural disaccharide, has been reported to ameliorate endothelial dysfunction during aging by activating endothelial nitric oxide synthase (eNOS); however, its role in I/R injury is unknown.	Trehalose	0-9	nitric oxide synthase 3	Rattus norvegicus	153-157
35578066-12	2022	The eNOS dimerization ratio was increased by trehalose (1.2 +- 0.2 vs. 1.6 +- 0.2; P = 0.023, d = 2.1), which was associated with the recovery of RPP and CF.	Trehalose	45-54	nitric oxide synthase 3	Rattus norvegicus	4-8
35578066-13	2022	These effects of trehalose were abolished by the eNOS inhibitor.	Trehalose	17-26	nitric oxide synthase 3	Rattus norvegicus	49-53
35578066-14	2022	Trehalose preconditioning showed protective effects on cardiac and coronary endothelial function after I/R through the eNOS signaling pathway.	Trehalose	0-9	nitric oxide synthase 3	Rattus norvegicus	119-123
35565744-1	2022	Trehalose solution ingested during exercise induces gradual increases in blood glucose levels and the insulin response compared with glucose solution.	Trehalose	0-9	insulin	Homo sapiens	102-109
35501124-9	2022	Moreover, we found that WT VCP, but not the mutants, counteracted lysosomal damage induced either by trehalose or by a mutant form of SOD1 (G93A), also blocking the formation of its insoluble intracellular aggregates.	Trehalose	101-110	valosin containing protein	Homo sapiens	27-30
35381374-0	2022	Trehalose induces B cell autophagy to alleviate myocardial injury via the AMPK/ULK1 signalling pathway in acute viral myocarditis induced by Coxsackie virus B3.	Trehalose	0-9	unc-51 like kinase 1	Mus musculus	79-83
35381374-5	2022	Trehalose alleviated myocardial injury in VMC mice and increased the number of autophagosomes, LC3II/LC3I ratio, and expression level of LAMP2, whereas it decreased the expression of p62 in VMC-B cells.	Trehalose	0-9	lysosomal-associated membrane protein 2	Mus musculus	137-142
35381374-5	2022	Trehalose alleviated myocardial injury in VMC mice and increased the number of autophagosomes, LC3II/LC3I ratio, and expression level of LAMP2, whereas it decreased the expression of p62 in VMC-B cells.	Trehalose	0-9	nucleoporin 62	Mus musculus	183-186
35381374-7	2022	At the mechanistic level, trehalose treatment significantly upregulated the phosphorylation of AMPK and ULK1 in VMC-B cells.	Trehalose	26-35	unc-51 like kinase 1	Mus musculus	104-108
35381374-9	2022	In conclusion, trehalose alleviates myocardial inflammatory damage of VMC by inducing B cell autophagy, mediated by the AMPK/ULK1 signalling pathway.	Trehalose	15-24	unc-51 like kinase 1	Mus musculus	125-129
35451658-6	2022	The tests were also performed with a trehalose-6-phosphate-synthase (TPS1)-deficient mutant strain (Deltatps1) unable to synthesize trehalose, and the results revealed that TPS1 was involved in protection against oxidative stress.	Trehalose	37-46	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	173-177
35451658-6	2022	The tests were also performed with a trehalose-6-phosphate-synthase (TPS1)-deficient mutant strain (Deltatps1) unable to synthesize trehalose, and the results revealed that TPS1 was involved in protection against oxidative stress.	Trehalose	132-141	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	173-177
35400664-0	2022	Trehalose inhibits ferroptosis via NRF2/HO-1 pathway and promotes functional recovery in mice with spinal cord injury.	Trehalose	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	35-39
35531069-13	2022	Trehalose and curcumin are novel agents acting on TFEB.	Trehalose	0-9	transcription factor EB	Homo sapiens	50-54
35450405-0	2022	Trehalose Protects Keratinocytes against Ultraviolet B Radiation by Activating Autophagy via Regulating TIMP3 and ATG9A.	Trehalose	0-9	TIMP metallopeptidase inhibitor 3	Homo sapiens	104-109
35450405-0	2022	Trehalose Protects Keratinocytes against Ultraviolet B Radiation by Activating Autophagy via Regulating TIMP3 and ATG9A.	Trehalose	0-9	autophagy related 9A	Homo sapiens	114-119
35450405-4	2022	In this study, coimmunoprecipitation, label-free quantitative proteomic and parallel reaction monitoring, and western blot analysis demonstrated that trehalose promotes the interaction between tissue inhibitor of metalloproteinase (TIMP) 3 and Beclin1.	Trehalose	150-159	TIMP metallopeptidase inhibitor 3	Homo sapiens	193-239
35450405-4	2022	In this study, coimmunoprecipitation, label-free quantitative proteomic and parallel reaction monitoring, and western blot analysis demonstrated that trehalose promotes the interaction between tissue inhibitor of metalloproteinase (TIMP) 3 and Beclin1.	Trehalose	150-159	beclin 1	Homo sapiens	244-251
35450405-5	2022	Western blot and immunofluorescence staining analysis suggested that trehalose increases ATG9A localization in lysosomes and decreases its localization in the endoplasmic reticulum.	Trehalose	69-78	autophagy related 9A	Homo sapiens	89-94
35450405-7	2022	The results revealed that in HaCaT cells, TIMP3 and ATG9A siRNA resulted in attenuation of trehalose-induced autophagy and inhibited cell death.	Trehalose	91-100	TIMP metallopeptidase inhibitor 3	Homo sapiens	42-47
35450405-7	2022	The results revealed that in HaCaT cells, TIMP3 and ATG9A siRNA resulted in attenuation of trehalose-induced autophagy and inhibited cell death.	Trehalose	91-100	autophagy related 9A	Homo sapiens	52-57
35450405-8	2022	In A431 cells, TIMP3 and ATG9A siRNA led to attenuation of trehalose-induced autophagy and cell death and inhibited migration.	Trehalose	59-68	TIMP metallopeptidase inhibitor 3	Homo sapiens	15-20
35450405-8	2022	In A431 cells, TIMP3 and ATG9A siRNA led to attenuation of trehalose-induced autophagy and cell death and inhibited migration.	Trehalose	59-68	autophagy related 9A	Homo sapiens	25-30
35450405-9	2022	In human epidermal keratinocytes, trehalose-induced autophagy and inhibition of the interleukin-8 expression were blocked by ATG9A but not TIMP3 siRNA.	Trehalose	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
35450405-9	2022	In human epidermal keratinocytes, trehalose-induced autophagy and inhibition of the interleukin-8 expression were blocked by ATG9A but not TIMP3 siRNA.	Trehalose	34-43	autophagy related 9A	Homo sapiens	125-130
35450405-11	2022	These findings suggest the protective effects of trehalose in normal keratinocytes and its inhibitory effects on cancerous keratinocytes, possibly mediated by activation of autophagy and regulation of TIMP3 and ATG9A, providing the mechanistic basis for the potential use of trehalose in the prevention or treatment of UVB-induced skin diseases.	Trehalose	49-58	TIMP metallopeptidase inhibitor 3	Homo sapiens	201-206
35450405-11	2022	These findings suggest the protective effects of trehalose in normal keratinocytes and its inhibitory effects on cancerous keratinocytes, possibly mediated by activation of autophagy and regulation of TIMP3 and ATG9A, providing the mechanistic basis for the potential use of trehalose in the prevention or treatment of UVB-induced skin diseases.	Trehalose	49-58	autophagy related 9A	Homo sapiens	211-216
35400664-0	2022	Trehalose inhibits ferroptosis via NRF2/HO-1 pathway and promotes functional recovery in mice with spinal cord injury.	Trehalose	0-9	heme oxygenase 1	Mus musculus	40-44
35400664-9	2022	In terms of mechanism, our results indicate that the neuroprotective effect of trehalose is due to the activation of the NRF2/HO-1 pathway, which in turn inhibits ferroptosis and ferroptosis-related inflammation.	Trehalose	79-88	nuclear factor, erythroid derived 2, like 2	Mus musculus	121-125
35400664-9	2022	In terms of mechanism, our results indicate that the neuroprotective effect of trehalose is due to the activation of the NRF2/HO-1 pathway, which in turn inhibits ferroptosis and ferroptosis-related inflammation.	Trehalose	79-88	heme oxygenase 1	Mus musculus	126-130
35455952-6	2022	Finally, mTOR-independent autophagy induction with trehalose resulted in a significant decrease in the lysosomes level sALS PBMCs.	Trehalose	51-60	mechanistic target of rapamycin kinase	Homo sapiens	9-13
35455952-8	2022	We also found that the induction of the mTOR-independent autophagy pathway leads to a decrease in lysosomes level, suggesting a more sensitivity of sALS PBMCs to trehalose.	Trehalose	162-171	mechanistic target of rapamycin kinase	Homo sapiens	40-44
35447782-1	2022	Trehalase regulates energy metabolism in insects by converting trehalose into two glucose molecules.	Trehalose	63-72	trehalase	Plutella xylostella	0-9
35066023-2	2022	The combined action of chemical chaperones trehalose, betaine and lysine on stability, aggregation and oligomeric state of muscle glycogen phosphorylase b (Phb) has been studied.	Trehalose	43-52	prohibitin 1	Homo sapiens	139-154
35066023-2	2022	The combined action of chemical chaperones trehalose, betaine and lysine on stability, aggregation and oligomeric state of muscle glycogen phosphorylase b (Phb) has been studied.	Trehalose	43-52	prohibitin 1	Homo sapiens	156-159
35066023-3	2022	Dynamic light scattering data indicate that the affinity of trehalose to Phb increased in the presence of betaine or lysine at both stages (stage of nucleation and aggregate growth) of enzyme aggregation at 48  C, in contrast, the affinity of betaine to the enzyme in the presence of lysine remained practically unchanged.	Trehalose	60-69	prohibitin 1	Homo sapiens	73-76
35066023-4	2022	According to differential scanning calorimetry and analytical ultracentrifugation data, the mixture of trehalose and betaine stabilized Phb stronger than either of them in total.	Trehalose	103-112	prohibitin 1	Homo sapiens	136-139
35199998-3	2022	Herein, a kind of nitric oxide (NO)-driven carrier-free nanomotor based on the reaction between trehalose (Tr, one of the mTOR-independent autophagy inducers), L-arginine (Arg), and phosphatidylserine (PS) is reported.	Trehalose	96-105	coagulation factor II thrombin receptor	Homo sapiens	107-109
35199998-3	2022	Herein, a kind of nitric oxide (NO)-driven carrier-free nanomotor based on the reaction between trehalose (Tr, one of the mTOR-independent autophagy inducers), L-arginine (Arg), and phosphatidylserine (PS) is reported.	Trehalose	96-105	mechanistic target of rapamycin kinase	Homo sapiens	122-126
35348612-0	2022	Exploring the mechanism of trehalose: dual functions of PI3K/Akt and VPS34/mTOR pathways in porcine oocytes and cumulus cells .	Trehalose	27-36	AKT serine/threonine kinase 1	Homo sapiens	61-64
35348612-0	2022	Exploring the mechanism of trehalose: dual functions of PI3K/Akt and VPS34/mTOR pathways in porcine oocytes and cumulus cells .	Trehalose	27-36	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	69-74
35348612-0	2022	Exploring the mechanism of trehalose: dual functions of PI3K/Akt and VPS34/mTOR pathways in porcine oocytes and cumulus cells .	Trehalose	27-36	mechanistic target of rapamycin kinase	Homo sapiens	75-79
35348612-4	2022	Trehalose has been reported as a novel mTOR-independent autophagy inducer in many cells.	Trehalose	0-9	mechanistic target of rapamycin kinase	Homo sapiens	39-43
35348612-7	2022	In this study, we found that trehalose plays a role as an autophagy activator by autophagic flux assay and determined that it promotes PI3K/Akt inhibition and VPS34/mTOR activation by immunoblotting, both in cumulus cells (CCs) and oocytes.	Trehalose	29-38	AKT serine/threonine kinase 1	Homo sapiens	140-143
35348612-7	2022	In this study, we found that trehalose plays a role as an autophagy activator by autophagic flux assay and determined that it promotes PI3K/Akt inhibition and VPS34/mTOR activation by immunoblotting, both in cumulus cells (CCs) and oocytes.	Trehalose	29-38	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	159-164
35348612-7	2022	In this study, we found that trehalose plays a role as an autophagy activator by autophagic flux assay and determined that it promotes PI3K/Akt inhibition and VPS34/mTOR activation by immunoblotting, both in cumulus cells (CCs) and oocytes.	Trehalose	29-38	mechanistic target of rapamycin kinase	Homo sapiens	165-169
35199998-3	2022	Herein, a kind of nitric oxide (NO)-driven carrier-free nanomotor based on the reaction between trehalose (Tr, one of the mTOR-independent autophagy inducers), L-arginine (Arg), and phosphatidylserine (PS) is reported.	Trehalose	96-105	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	172-175
35007820-3	2022	In Experiment 1, intracellular trehalose (trehalose hexaacetate; Tre-(OAc)6) was synthesized from trehalose precursor and subjected to spectroscopic characterization.	Trehalose	31-40	trehalase	Homo sapiens	65-75
35007820-3	2022	In Experiment 1, intracellular trehalose (trehalose hexaacetate; Tre-(OAc)6) was synthesized from trehalose precursor and subjected to spectroscopic characterization.	Trehalose	98-107	trehalase	Homo sapiens	65-75
35007820-8	2022	The highest concentration of intracellular trehalose was detected when the oocytes were incubated for 24 h with 30 mM Tre-(OAc)6.	Trehalose	43-52	trehalase	Homo sapiens	118-128
35007820-13	2022	Our results lead us to infer that increasing the levels of intracellular trehalose by Tre-(OAc)6 during oocyte maturation improves the freezing ability of feline oocytes, albeit at specific concentrations.	Trehalose	73-82	trehalase	Homo sapiens	86-96
35045351-12	2022	Also, there was a significant difference between changes in alanine aminotransferase (ALT) trehalose and placebo groups.	Trehalose	91-100	glutamic--pyruvic transaminase	Homo sapiens	60-84
35013770-8	2022	LC3-II increased comparably in both groups, while p62 was significantly lower in the SVR + trehalose group than in the SVR alone group (P < 0.01).	Trehalose	91-100	annexin A3	Rattus norvegicus	0-3
35013770-8	2022	LC3-II increased comparably in both groups, while p62 was significantly lower in the SVR + trehalose group than in the SVR alone group (P < 0.01).	Trehalose	91-100	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	50-53
35463818-0	2022	Effects of trehalose on NFE2L2, catalase, and superoxide dismutase in the kidney of aged rats.	Trehalose	11-20	catalase	Rattus norvegicus	32-40
35463818-7	2022	Protein levels of NFE2L2 showed a 50% reduction in aged rats compared to young rats (P<0.001), which was restored by trehalose intervention.	Trehalose	117-126	NFE2 like bZIP transcription factor 2	Rattus norvegicus	18-24
35463818-8	2022	In addition, the activity and mRNA levels of catalase (CAT) increased in aged rats while treatment with trehalose reversed this trend.	Trehalose	104-113	catalase	Rattus norvegicus	45-53
35463818-8	2022	In addition, the activity and mRNA levels of catalase (CAT) increased in aged rats while treatment with trehalose reversed this trend.	Trehalose	104-113	catalase	Rattus norvegicus	55-58
35360323-6	2022	Furthermore, trehalose pretreatment promoted trehalose metabolism; significantly increased the enzymatic activity of the trehalose metabolic pathway, including trehalose-6-phosphate synthase (TPS), trehalose-6-phosphate phosphatase (TPP), and trehalase (TRE); and upregulated the expression of SlTPS1, SlTPS5, SlTPS7, SlTPPJ, SlTPPH, and SlTRE under saline conditions.	Trehalose	13-22	trehalose-6-phosphate synthase	Solanum lycopersicum	160-190
35360323-6	2022	Furthermore, trehalose pretreatment promoted trehalose metabolism; significantly increased the enzymatic activity of the trehalose metabolic pathway, including trehalose-6-phosphate synthase (TPS), trehalose-6-phosphate phosphatase (TPP), and trehalase (TRE); and upregulated the expression of SlTPS1, SlTPS5, SlTPS7, SlTPPJ, SlTPPH, and SlTRE under saline conditions.	Trehalose	13-22	trehalose-6-phosphate synthase	Solanum lycopersicum	192-195
35360323-6	2022	Furthermore, trehalose pretreatment promoted trehalose metabolism; significantly increased the enzymatic activity of the trehalose metabolic pathway, including trehalose-6-phosphate synthase (TPS), trehalose-6-phosphate phosphatase (TPP), and trehalase (TRE); and upregulated the expression of SlTPS1, SlTPS5, SlTPS7, SlTPPJ, SlTPPH, and SlTRE under saline conditions.	Trehalose	13-22	trehalose-6-phosphate synthase	Solanum lycopersicum	294-300
35360323-6	2022	Furthermore, trehalose pretreatment promoted trehalose metabolism; significantly increased the enzymatic activity of the trehalose metabolic pathway, including trehalose-6-phosphate synthase (TPS), trehalose-6-phosphate phosphatase (TPP), and trehalase (TRE); and upregulated the expression of SlTPS1, SlTPS5, SlTPS7, SlTPPJ, SlTPPH, and SlTRE under saline conditions.	Trehalose	13-22	linalool synthase	Solanum lycopersicum	302-308
35360323-6	2022	Furthermore, trehalose pretreatment promoted trehalose metabolism; significantly increased the enzymatic activity of the trehalose metabolic pathway, including trehalose-6-phosphate synthase (TPS), trehalose-6-phosphate phosphatase (TPP), and trehalase (TRE); and upregulated the expression of SlTPS1, SlTPS5, SlTPS7, SlTPPJ, SlTPPH, and SlTRE under saline conditions.	Trehalose	13-22	(E)-beta-ocimene synthase	Solanum lycopersicum	310-316
35360323-6	2022	Furthermore, trehalose pretreatment promoted trehalose metabolism; significantly increased the enzymatic activity of the trehalose metabolic pathway, including trehalose-6-phosphate synthase (TPS), trehalose-6-phosphate phosphatase (TPP), and trehalase (TRE); and upregulated the expression of SlTPS1, SlTPS5, SlTPS7, SlTPPJ, SlTPPH, and SlTRE under saline conditions.	Trehalose	121-130	trehalose-6-phosphate synthase	Solanum lycopersicum	160-190
35360323-6	2022	Furthermore, trehalose pretreatment promoted trehalose metabolism; significantly increased the enzymatic activity of the trehalose metabolic pathway, including trehalose-6-phosphate synthase (TPS), trehalose-6-phosphate phosphatase (TPP), and trehalase (TRE); and upregulated the expression of SlTPS1, SlTPS5, SlTPS7, SlTPPJ, SlTPPH, and SlTRE under saline conditions.	Trehalose	121-130	trehalose-6-phosphate synthase	Solanum lycopersicum	192-195
35360323-6	2022	Furthermore, trehalose pretreatment promoted trehalose metabolism; significantly increased the enzymatic activity of the trehalose metabolic pathway, including trehalose-6-phosphate synthase (TPS), trehalose-6-phosphate phosphatase (TPP), and trehalase (TRE); and upregulated the expression of SlTPS1, SlTPS5, SlTPS7, SlTPPJ, SlTPPH, and SlTRE under saline conditions.	Trehalose	121-130	trehalose-6-phosphate synthase	Solanum lycopersicum	294-300
35360323-6	2022	Furthermore, trehalose pretreatment promoted trehalose metabolism; significantly increased the enzymatic activity of the trehalose metabolic pathway, including trehalose-6-phosphate synthase (TPS), trehalose-6-phosphate phosphatase (TPP), and trehalase (TRE); and upregulated the expression of SlTPS1, SlTPS5, SlTPS7, SlTPPJ, SlTPPH, and SlTRE under saline conditions.	Trehalose	121-130	linalool synthase	Solanum lycopersicum	302-308
35360323-6	2022	Furthermore, trehalose pretreatment promoted trehalose metabolism; significantly increased the enzymatic activity of the trehalose metabolic pathway, including trehalose-6-phosphate synthase (TPS), trehalose-6-phosphate phosphatase (TPP), and trehalase (TRE); and upregulated the expression of SlTPS1, SlTPS5, SlTPS7, SlTPPJ, SlTPPH, and SlTRE under saline conditions.	Trehalose	121-130	(E)-beta-ocimene synthase	Solanum lycopersicum	310-316
35194654-6	2022	The overexpression of ELM1 increased the accumulation of trehalose and ergosterol and altered the composition of fatty acids with altered gene expressions involved in the metabolism of three metabolites.	Trehalose	57-66	serine/threonine protein kinase ELM1	Saccharomyces cerevisiae S288C	22-26
35194654-7	2022	Enhanced resistance to heat shock stress in SAK1 overexpression might be related to the enhanced accumulation of trehalose and ergosterol and upregulated transcription of genes related to the metabolism of trehalose and ergosterol.	Trehalose	113-122	serine/threonine protein kinase SAK1	Saccharomyces cerevisiae S288C	44-48
35194654-7	2022	Enhanced resistance to heat shock stress in SAK1 overexpression might be related to the enhanced accumulation of trehalose and ergosterol and upregulated transcription of genes related to the metabolism of trehalose and ergosterol.	Trehalose	206-215	serine/threonine protein kinase SAK1	Saccharomyces cerevisiae S288C	44-48
35194654-8	2022	Furthermore, Elm1 might regulate the metabolism of trehalose, ergosterol, and fatty acids in a Snf1-independent form under high-glucose stress.	Trehalose	51-60	serine/threonine protein kinase ELM1	Saccharomyces cerevisiae S288C	13-17
35194654-9	2022	A Snf1-independent pathway might be involved in the regulation of trehalose metabolism by Sak1 under heat shock condition.	Trehalose	66-75	serine/threonine protein kinase SAK1	Saccharomyces cerevisiae S288C	90-94
35196199-8	2022	Treatment of APOE-mice with metformin or trehalose ameliorated the loss of retinal function and reduced Bruch"s membrane thickening, enhancing LC3 and LAMP1 labeling in the ocular tissues and restoring LC3-II:LC3-I ratio to WT levels.	Trehalose	41-50	apolipoprotein E	Mus musculus	13-17
35196199-8	2022	Treatment of APOE-mice with metformin or trehalose ameliorated the loss of retinal function and reduced Bruch"s membrane thickening, enhancing LC3 and LAMP1 labeling in the ocular tissues and restoring LC3-II:LC3-I ratio to WT levels.	Trehalose	41-50	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	143-146
35196199-8	2022	Treatment of APOE-mice with metformin or trehalose ameliorated the loss of retinal function and reduced Bruch"s membrane thickening, enhancing LC3 and LAMP1 labeling in the ocular tissues and restoring LC3-II:LC3-I ratio to WT levels.	Trehalose	41-50	lysosomal-associated membrane protein 1	Mus musculus	151-156
35196199-8	2022	Treatment of APOE-mice with metformin or trehalose ameliorated the loss of retinal function and reduced Bruch"s membrane thickening, enhancing LC3 and LAMP1 labeling in the ocular tissues and restoring LC3-II:LC3-I ratio to WT levels.	Trehalose	41-50	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	202-205
35196199-8	2022	Treatment of APOE-mice with metformin or trehalose ameliorated the loss of retinal function and reduced Bruch"s membrane thickening, enhancing LC3 and LAMP1 labeling in the ocular tissues and restoring LC3-II:LC3-I ratio to WT levels.	Trehalose	41-50	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	209-212
35196199-10	2022	Additionally, trehalose increased p-MAPK14/p38 to enhance autophagy.	Trehalose	14-23	mitogen-activated protein kinase 14	Mus musculus	36-42
35196199-10	2022	Additionally, trehalose increased p-MAPK14/p38 to enhance autophagy.	Trehalose	14-23	mitogen-activated protein kinase 14	Mus musculus	43-46