PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8625495-2	1996	Our previous study demonstrated that cytochrome P450 (P450) 1A2 catalyzes the formation of 4-hydroxy-1-(3-pyridyl)-1-butanone (keto alcohol) (an alpha-hydroxylation product) from NNK in human liver microsomes.	4-hydroxy-1-(3-pyridyl)-1-butanone	91-125	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	37-63
8319620-1	1993	Hemoglobin adducts of the common metabolite of the tobacco-specific nitrosamine (TSNA) 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and of 4-aminobiphenyl (4-ABP) were quantified in blood samples from smokers and nonsmokers to test their suitability for biomonitoring tobacco smoke exposure.	4-hydroxy-1-(3-pyridyl)-1-butanone	123-126	auxin-binding protein T92	Nicotiana tabacum	154-157
31026483-9	2019	The amounts of HPB from Alb adducts in smoker plasma averaged 1.82 +- 0.19 pg/mg Alb (0.42 to 3.11 pg/mg Alb), which was 36 times the value in nonsmokers (0.05 +- 0.01 pg/mg Alb).	4-hydroxy-1-(3-pyridyl)-1-butanone	15-18	albumin	Homo sapiens	24-27
31026483-9	2019	The amounts of HPB from Alb adducts in smoker plasma averaged 1.82 +- 0.19 pg/mg Alb (0.42 to 3.11 pg/mg Alb), which was 36 times the value in nonsmokers (0.05 +- 0.01 pg/mg Alb).	4-hydroxy-1-(3-pyridyl)-1-butanone	15-18	albumin	Homo sapiens	81-84
31026483-9	2019	The amounts of HPB from Alb adducts in smoker plasma averaged 1.82 +- 0.19 pg/mg Alb (0.42 to 3.11 pg/mg Alb), which was 36 times the value in nonsmokers (0.05 +- 0.01 pg/mg Alb).	4-hydroxy-1-(3-pyridyl)-1-butanone	15-18	albumin	Homo sapiens	81-84
31026483-9	2019	The amounts of HPB from Alb adducts in smoker plasma averaged 1.82 +- 0.19 pg/mg Alb (0.42 to 3.11 pg/mg Alb), which was 36 times the value in nonsmokers (0.05 +- 0.01 pg/mg Alb).	4-hydroxy-1-(3-pyridyl)-1-butanone	15-18	albumin	Homo sapiens	81-84
31026483-10	2019	Importantly, HPB level from Alb correlated positively with the level of human tobacco exposure estimated by urinary total nicotine equivalent (TNE) (R2 = 0.6170).	4-hydroxy-1-(3-pyridyl)-1-butanone	13-16	albumin	Homo sapiens	28-31