PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22999639-6	2013	In conclusion, ROS induced by 7-oxysterols may function as an early initiator of Egr1 expression.	7-oxysterols	30-42	early growth response 1	Homo sapiens	81-85
23415904-8	2013	Reduction and oxidation of 7-oxysterols by murine 11betaHSD1 proceeded more slowly and substrate affinity was lower than for glucocorticoids.	7-oxysterols	27-39	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	50-60
22999639-7	2013	The late induced p53 by 7-oxysterols contributes to apoptotic cell death and is linked to the reduction of Egr1 levels, which resembles the differential expression of p53 and Egr1 in human atheroma progression.	7-oxysterols	24-36	tumor protein p53	Homo sapiens	17-20
22999639-7	2013	The late induced p53 by 7-oxysterols contributes to apoptotic cell death and is linked to the reduction of Egr1 levels, which resembles the differential expression of p53 and Egr1 in human atheroma progression.	7-oxysterols	24-36	early growth response 1	Homo sapiens	107-111
22999639-7	2013	The late induced p53 by 7-oxysterols contributes to apoptotic cell death and is linked to the reduction of Egr1 levels, which resembles the differential expression of p53 and Egr1 in human atheroma progression.	7-oxysterols	24-36	tumor protein p53	Homo sapiens	167-170
22999639-7	2013	The late induced p53 by 7-oxysterols contributes to apoptotic cell death and is linked to the reduction of Egr1 levels, which resembles the differential expression of p53 and Egr1 in human atheroma progression.	7-oxysterols	24-36	early growth response 1	Homo sapiens	175-179
22985798-0	2012	Cell death induced by 7-oxysterols via lysosomal and mitochondrial pathways is p53-dependent.	7-oxysterols	22-34	tumor protein p53	Homo sapiens	79-82
22985798-4	2012	We show here that 7-oxysterols induce endogenous full-length p53 and phospho-p53 (p53-Ser15) in both nucleus and cytoplasm of THP1 and J774 cells, which is followed by cellular oxidative stress and apoptotic cell death.	7-oxysterols	18-30	tumor protein p53	Homo sapiens	61-64
22985798-4	2012	We show here that 7-oxysterols induce endogenous full-length p53 and phospho-p53 (p53-Ser15) in both nucleus and cytoplasm of THP1 and J774 cells, which is followed by cellular oxidative stress and apoptotic cell death.	7-oxysterols	18-30	tumor protein p53	Homo sapiens	77-80
22985798-4	2012	We show here that 7-oxysterols induce endogenous full-length p53 and phospho-p53 (p53-Ser15) in both nucleus and cytoplasm of THP1 and J774 cells, which is followed by cellular oxidative stress and apoptotic cell death.	7-oxysterols	18-30	tumor protein p53	Homo sapiens	77-80
22985798-4	2012	We show here that 7-oxysterols induce endogenous full-length p53 and phospho-p53 (p53-Ser15) in both nucleus and cytoplasm of THP1 and J774 cells, which is followed by cellular oxidative stress and apoptotic cell death.	7-oxysterols	18-30	GLI family zinc finger 2	Homo sapiens	126-130
22985798-6	2012	These results reveal that 7-oxysterols induce induction and nuclear translocation of p53 in M1-t-p53 cells, which in turn enhances LMP, mitochondrial translocation of Bax, mitochondrial membrane permeabilization, cytosolic release of cytochrome c, and cell death.	7-oxysterols	26-38	tumor protein p53	Homo sapiens	85-88
22985798-6	2012	These results reveal that 7-oxysterols induce induction and nuclear translocation of p53 in M1-t-p53 cells, which in turn enhances LMP, mitochondrial translocation of Bax, mitochondrial membrane permeabilization, cytosolic release of cytochrome c, and cell death.	7-oxysterols	26-38	tumor protein p53	Homo sapiens	97-100
22985798-6	2012	These results reveal that 7-oxysterols induce induction and nuclear translocation of p53 in M1-t-p53 cells, which in turn enhances LMP, mitochondrial translocation of Bax, mitochondrial membrane permeabilization, cytosolic release of cytochrome c, and cell death.	7-oxysterols	26-38	BCL2 associated X, apoptosis regulator	Homo sapiens	167-170
22985798-6	2012	These results reveal that 7-oxysterols induce induction and nuclear translocation of p53 in M1-t-p53 cells, which in turn enhances LMP, mitochondrial translocation of Bax, mitochondrial membrane permeabilization, cytosolic release of cytochrome c, and cell death.	7-oxysterols	26-38	cytochrome c, somatic	Homo sapiens	234-246
20100573-4	2010	Several earlier and recent studies, mainly performed in vitro, revealed a relatively broad substrate spectrum of 11beta-HSD1 and suggested that this enzyme has additional functions in the metabolism of some neurosteroids (7-oxy- and 11-oxyandrogens and -progestins) and 7-oxysterols, as well as in the detoxification of various xenobiotics that contain reactive carbonyl groups.	7-oxysterols	270-282	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	113-124
20798376-3	2010	It was previously reported that ABCG1 protects against dietary cholesterol-induced endothelial dysfunction by promoting the efflux of 7-oxysterols to HDL.	7-oxysterols	134-146	ATP binding cassette subfamily G member 1	Mus musculus	32-37
31136841-11	2019	We suggest that BMP favors the egress of cholesterol from late endosomes via an ORP11-dependent mechanism, resulting in a reduced production of cytotoxic 7-oxysterols.	7-oxysterols	154-166	oxysterol binding protein-like 11	Mus musculus	80-85
28350877-0	2017	Exposure to atheroma-relevant 7-oxysterols causes proteomic alterations in cell death, cellular longevity, and lipid metabolism in THP-1 macrophages.	7-oxysterols	30-42	GLI family zinc finger 2	Homo sapiens	131-136
18924609-10	2008	Our data suggest that ABCG1 and HDL maintain EC function in HCD-fed mice by promoting efflux of cholesterol and 7-oxysterols and preserving active eNOS dimer levels.	7-oxysterols	112-124	ATP binding cassette subfamily G member 1	Mus musculus	22-27