PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22664382-3	2012	After sandwich-type reaction, numerous ALP were captured onto the aptasensor surface and catalyzed the hydrolysis of ascorbic acid 2-phosphate (AAP), which in situ generated ascorbic acid (AA), reducing Ag(+) to Ag nanoparticles (AgNPs) for electrochemical readout.	ascorbate-2-phosphate	117-142	alkaline phosphatase, placental	Homo sapiens	39-42
22664382-3	2012	After sandwich-type reaction, numerous ALP were captured onto the aptasensor surface and catalyzed the hydrolysis of ascorbic acid 2-phosphate (AAP), which in situ generated ascorbic acid (AA), reducing Ag(+) to Ag nanoparticles (AgNPs) for electrochemical readout.	ascorbate-2-phosphate	144-147	alkaline phosphatase, placental	Homo sapiens	39-42
22113359-1	2012	In pH 8.9 Tris-HCl buffer solutions, alkaline phosphatase (ALP) catalyzed the hydrolysis of ascorbic acid 2-phosphate (AAP) substrate to form ascorbic acid.	ascorbate-2-phosphate	92-117	alkaline phosphatase, placental	Homo sapiens	37-57
22113359-1	2012	In pH 8.9 Tris-HCl buffer solutions, alkaline phosphatase (ALP) catalyzed the hydrolysis of ascorbic acid 2-phosphate (AAP) substrate to form ascorbic acid.	ascorbate-2-phosphate	119-122	alkaline phosphatase, placental	Homo sapiens	37-57
20701628-0	2010	L-ascorbic acid 2-phosphate represses the dihydrotestosterone-induced dickkopf-1 expression in human balding dermal papilla cells.	ascorbate-2-phosphate	0-27	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	70-80
21696941-4	2011	Furthermore, ALP on the electrode surface could catalyze hydrolysis of ascorbic acid 2-phosphate to in-situ produce ascorbic acid, which co-reacted with Ru(bpy)(3)(2+) to obtain quite fast, stable and greatly amplified ECL signal.	ascorbate-2-phosphate	71-96	ATHS	Homo sapiens	13-16
20701628-3	2010	Here, we investigated whether L-ascorbic acid 2-phosphate (Asc 2-P), a derivative of L-ascorbic acid, could attenuate DHT-induced DKK-1 expression in dermal papilla cells (DPCs) from balding scalp.	ascorbate-2-phosphate	30-57	pyrin domain containing 1	Homo sapiens	59-64
20701628-3	2010	Here, we investigated whether L-ascorbic acid 2-phosphate (Asc 2-P), a derivative of L-ascorbic acid, could attenuate DHT-induced DKK-1 expression in dermal papilla cells (DPCs) from balding scalp.	ascorbate-2-phosphate	30-57	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	130-135
21034532-2	2010	We also demonstrated that L-ascorbic acid 2-phosphate (Asc 2-P) represses DHT-induced DKK-1 expression in cultured dermal papilla cells (DPCs).	ascorbate-2-phosphate	26-53	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	86-91
21034532-2	2010	We also demonstrated that L-ascorbic acid 2-phosphate (Asc 2-P) represses DHT-induced DKK-1 expression in cultured dermal papilla cells (DPCs).	ascorbate-2-phosphate	55-62	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	86-91
20206003-5	2010	ALP on the electrode surface initiated the hydrolysis of ascorbic acid 2-phosphate (AA-p) to produce ascorbic acid.	ascorbate-2-phosphate	57-82	alkaline phosphatase, placental	Homo sapiens	0-3
20206003-5	2010	ALP on the electrode surface initiated the hydrolysis of ascorbic acid 2-phosphate (AA-p) to produce ascorbic acid.	ascorbate-2-phosphate	84-88	alkaline phosphatase, placental	Homo sapiens	0-3
19678762-6	2010	After 5 weeks of cultivation, the addition of osteogenic supplements (dexamethasone, sodium-beta-glycerophosphate, and ascorbic acid-2-phosphate) to culture medium significantly increased the construct cellularity and the amounts of bone matrix components (collagen, bone sialoprotein, and bone osteopontin).	ascorbate-2-phosphate	119-144	secreted phosphoprotein 1	Homo sapiens	295-306
20233500-3	2010	In this study, we developed thick and highly cell-incorporated engineered tissues by using basic fibroblast growth factor (bFGF) and ascorbic acid 2-phosphate (Asc 2-P).	ascorbate-2-phosphate	133-158	pyrin domain containing 1	Homo sapiens	160-165
19837997-3	2009	Histochemistry revealed morphologically distinct, chondrocyte-like cells, surrounded by a sulfated proteoglycan-rich extracellular matrix in the group treated with bone morphogenetic protein 2 (BMP-2), while cells cultured with dexamethasone, ascorbate-2-phosphate, and beta-glycerophosphate displayed a spindle-shaped morphology and deposited a mineralized matrix.	ascorbate-2-phosphate	243-264	bone morphogenetic protein 2	Homo sapiens	164-192
19416266-0	2009	l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase.	ascorbate-2-phosphate	0-27	insulin like growth factor 1	Homo sapiens	84-112
19416266-1	2009	BACKGROUND: l-Ascorbic acid 2-phosphate (Asc 2-P), a derivative of l-ascorbic acid, promotes elongation of hair shafts in cultured human hair follicles and induces hair growth in mice.	ascorbate-2-phosphate	12-39	pyrin domain containing 1	Homo sapiens	41-46
17964763-0	2008	Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells.	ascorbate-2-phosphate	81-106	cyclin A2	Homo sapiens	30-34
18728347-7	2009	Bone marrow stromal cells isolated from ank/ank mice cultured in the presence of ascorbate-2-phosphate for up to 35 days showed markedly reduced mineralization compared to the mineralization of bone marrow stromal cells isolated from wild-type littermates.	ascorbate-2-phosphate	81-102	progressive ankylosis	Mus musculus	40-43
18728347-7	2009	Bone marrow stromal cells isolated from ank/ank mice cultured in the presence of ascorbate-2-phosphate for up to 35 days showed markedly reduced mineralization compared to the mineralization of bone marrow stromal cells isolated from wild-type littermates.	ascorbate-2-phosphate	81-102	progressive ankylosis	Mus musculus	44-47
27873839-4	2008	The amperometric biosensor was based on the reaction of ALP with the substrate ascorbic acid 2-phosphate (AA2P).	ascorbate-2-phosphate	79-104	alkaline phosphatase, placental	Homo sapiens	56-59
27873839-4	2008	The amperometric biosensor was based on the reaction of ALP with the substrate ascorbic acid 2-phosphate (AA2P).	ascorbate-2-phosphate	106-110	alkaline phosphatase, placental	Homo sapiens	56-59
17964763-0	2008	Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells.	ascorbate-2-phosphate	81-106	cellular communication network factor 2	Homo sapiens	39-43
15109981-1	2004	In order to investigate the effect of ascorbic acid (AsA) and ascorbic acid 2-phosphate (Asc 2-P), a long-acting vitamin C derivative, on the growth and differentiation of human osteoblast-like cells, we supplemented the culture medium of MG-63 cells with various concentrations (0.25 to 1 mM) of these factors.	ascorbate-2-phosphate	62-87	pyrin domain containing 1	Homo sapiens	89-94
15086777-2	2004	Alkaline phosphatase-expressing cells were most frequently observed when the hMSCs were treated with 2.5 ng/ml of basic fibroblast growth factor (bFGF) and 50 ng/ml of bone morphogenetic protein (BMP)-2 for 4 days in culture after a 6-day incubation in osteogenic medium containing dexamethasone, ascorbic acid-2-phosphate, and beta-glycerophosphate.	ascorbate-2-phosphate	297-322	fibroblast growth factor 2	Homo sapiens	114-144
15086777-2	2004	Alkaline phosphatase-expressing cells were most frequently observed when the hMSCs were treated with 2.5 ng/ml of basic fibroblast growth factor (bFGF) and 50 ng/ml of bone morphogenetic protein (BMP)-2 for 4 days in culture after a 6-day incubation in osteogenic medium containing dexamethasone, ascorbic acid-2-phosphate, and beta-glycerophosphate.	ascorbate-2-phosphate	297-322	fibroblast growth factor 2	Homo sapiens	146-150
15086777-2	2004	Alkaline phosphatase-expressing cells were most frequently observed when the hMSCs were treated with 2.5 ng/ml of basic fibroblast growth factor (bFGF) and 50 ng/ml of bone morphogenetic protein (BMP)-2 for 4 days in culture after a 6-day incubation in osteogenic medium containing dexamethasone, ascorbic acid-2-phosphate, and beta-glycerophosphate.	ascorbate-2-phosphate	297-322	bone morphogenetic protein 2	Homo sapiens	168-202
11169457-4	2001	Following culture in 10% FCS in alphaMEM containing ascorbate-2-phosphate and dexamethasone the amplified cells expressed the osteoblast phenotype as determined by expression of osteocalcin protein determined immunohistochemically, and Type I collagen and osteocalcin mRNA expressions determined by RT-PCR analysis.	ascorbate-2-phosphate	52-73	bone gamma-carboxyglutamate protein	Homo sapiens	178-189
12951508-3	2003	The TIMP-3 transfectants produced type I collagen at the same level as that of normal cells in response to ascorbic acid 2-phosphate (AscP).	ascorbate-2-phosphate	107-132	tissue inhibitor of metalloproteinase 3	Mus musculus	4-10
12951508-3	2003	The TIMP-3 transfectants produced type I collagen at the same level as that of normal cells in response to ascorbic acid 2-phosphate (AscP).	ascorbate-2-phosphate	134-138	tissue inhibitor of metalloproteinase 3	Mus musculus	4-10
11169457-4	2001	Following culture in 10% FCS in alphaMEM containing ascorbate-2-phosphate and dexamethasone the amplified cells expressed the osteoblast phenotype as determined by expression of osteocalcin protein determined immunohistochemically, and Type I collagen and osteocalcin mRNA expressions determined by RT-PCR analysis.	ascorbate-2-phosphate	52-73	bone gamma-carboxyglutamate protein	Homo sapiens	256-267
10984304-8	1998	Another stable AsA derivative, ascorbic acid 2-phosphate (AA-2P) effectively promoted basal and EGF-induced HGF secretion by the fibroblasts, but ascorbic acid 2-sulfate (AA-2S) was much less effective.	ascorbate-2-phosphate	31-56	hepatocyte growth factor	Homo sapiens	108-111
8777435-2	1995	UV susceptibility was appreciably reduced by the reactive oxygen species (ROS)-scavenger L-ascorbic acid-2-phosphate (Asc2P) endowed with long-lasting functions but not by L-ascorbic acid (Asc) for each cell type.	ascorbate-2-phosphate	89-116	steroid sulfatase	Homo sapiens	118-121
8524865-4	1995	Insulin release from scorbutic islets was greatly elevated if 5 mM L-ascorbic acid 2-phosphate was supplemented in the perifusion medium during the last 60 min of perifusion.	ascorbate-2-phosphate	67-94	insulin	Cavia porcellus	0-7
8524865-5	1995	When 5 mM L-ascorbic acid 2-phosphate was added to the perifusion medium concurrently with elevation of medium D-glucose, islets from scorbutic guinea pigs released insulin as rapidly as control guinea pig islets and to a somewhat greater extent.	ascorbate-2-phosphate	10-37	insulin	Cavia porcellus	165-172
9039287-1	1997	The addition of L-ascorbic acid 2-phosphate (Asc 2-P), which is active and stable under a conventional culture condition, could render dermal fibroblasts to the organization of a dermis-like structure on a plastic dish without any prior treatment.	ascorbate-2-phosphate	16-43	pyrin domain containing 1	Homo sapiens	45-50
7865478-1	1994	We performed the quantitative and qualitative analysis on the main disaccharide units of glycosaminoglycans produced by human dermal fibroblasts in the 3-dimensional culture supplemented with L-ascorbic acid 2-phosphate (Asc 2-p) comparing with the monolayer culture system.	ascorbate-2-phosphate	192-219	pyrin domain containing 1	Homo sapiens	221-226
7887121-5	1994	Co-cultures of hepatic parenchymal cells and fibroblasts formed a three-dimensional hepatic cord-like architecture in the medium supplemented with a long-acting vitamin C derivative, L-ascorbic acid 2-phosphate (Asc 2-P).	ascorbate-2-phosphate	183-210	pyrin domain containing 1	Homo sapiens	212-217
34791532-4	2021	After the sandwich immunoreactions were accomplished, the alkaline phosphatase (ALP) hydrolyzed L-ascorbic acid 2-phosphate (AAP) to form ascorbic acid (AA) that further reduces Ag+ and Cu2+ to Ag NPs and Cu+, respectively.	ascorbate-2-phosphate	96-123	alkaline phosphatase, placental	Homo sapiens	80-83
2033086-3	1991	The accumulation of pro alpha 1(I) and pro alpha 2(I) mRNAs and the transcriptional activity of these genes were determined in human skin fibroblasts in order to investigate site(s) of regulation of type I collagen production by human EGF in the absence and presence of L-ascorbic acid 2-phosphate (Asc 2-P), a long-acting vitamin C derivative.	ascorbate-2-phosphate	270-297	epidermal growth factor	Homo sapiens	235-238
33825047-3	2021	The ascorbic acid 2-phosphate (AAP) can be hydrolyzed by alkaline phosphatase (ALP) to yield ascorbic acid (AA).	ascorbate-2-phosphate	4-29	alkaline phosphatase, placental	Homo sapiens	57-77
33825047-3	2021	The ascorbic acid 2-phosphate (AAP) can be hydrolyzed by alkaline phosphatase (ALP) to yield ascorbic acid (AA).	ascorbate-2-phosphate	4-29	alkaline phosphatase, placental	Homo sapiens	79-82
33825047-3	2021	The ascorbic acid 2-phosphate (AAP) can be hydrolyzed by alkaline phosphatase (ALP) to yield ascorbic acid (AA).	ascorbate-2-phosphate	31-34	alkaline phosphatase, placental	Homo sapiens	57-77
33825047-3	2021	The ascorbic acid 2-phosphate (AAP) can be hydrolyzed by alkaline phosphatase (ALP) to yield ascorbic acid (AA).	ascorbate-2-phosphate	31-34	alkaline phosphatase, placental	Homo sapiens	79-82
33237050-5	2021	Alkaline phosphatase (ALP) can catalyze the hydrolysis of ascorbic acid 2-phosphate (AAP) to produce AA.	ascorbate-2-phosphate	58-83	alkaline phosphatase, placental	Homo sapiens	0-20
33237050-5	2021	Alkaline phosphatase (ALP) can catalyze the hydrolysis of ascorbic acid 2-phosphate (AAP) to produce AA.	ascorbate-2-phosphate	58-83	alkaline phosphatase, placental	Homo sapiens	22-25
33237050-5	2021	Alkaline phosphatase (ALP) can catalyze the hydrolysis of ascorbic acid 2-phosphate (AAP) to produce AA.	ascorbate-2-phosphate	85-88	alkaline phosphatase, placental	Homo sapiens	0-20
33237050-5	2021	Alkaline phosphatase (ALP) can catalyze the hydrolysis of ascorbic acid 2-phosphate (AAP) to produce AA.	ascorbate-2-phosphate	85-88	alkaline phosphatase, placental	Homo sapiens	22-25
34958552-5	2022	On the basis of catalyzing the dephosphorylation process of l-ascorbic acid-2-phosphate to yield AA via alkaline phosphatase (ALP) and AA-dependent signal responses, a universal fluorescent system has been successfully constructed for quantitative measurement of the activity of ALP and the ALP-related enzyme-linked immunosorbent assay with carcinoembryonic antigen as a model.	ascorbate-2-phosphate	60-87	alkaline phosphatase, placental	Homo sapiens	104-124
34958552-5	2022	On the basis of catalyzing the dephosphorylation process of l-ascorbic acid-2-phosphate to yield AA via alkaline phosphatase (ALP) and AA-dependent signal responses, a universal fluorescent system has been successfully constructed for quantitative measurement of the activity of ALP and the ALP-related enzyme-linked immunosorbent assay with carcinoembryonic antigen as a model.	ascorbate-2-phosphate	60-87	alkaline phosphatase, placental	Homo sapiens	126-129
34958552-5	2022	On the basis of catalyzing the dephosphorylation process of l-ascorbic acid-2-phosphate to yield AA via alkaline phosphatase (ALP) and AA-dependent signal responses, a universal fluorescent system has been successfully constructed for quantitative measurement of the activity of ALP and the ALP-related enzyme-linked immunosorbent assay with carcinoembryonic antigen as a model.	ascorbate-2-phosphate	60-87	alkaline phosphatase, placental	Homo sapiens	279-282
34958552-5	2022	On the basis of catalyzing the dephosphorylation process of l-ascorbic acid-2-phosphate to yield AA via alkaline phosphatase (ALP) and AA-dependent signal responses, a universal fluorescent system has been successfully constructed for quantitative measurement of the activity of ALP and the ALP-related enzyme-linked immunosorbent assay with carcinoembryonic antigen as a model.	ascorbate-2-phosphate	60-87	alkaline phosphatase, placental	Homo sapiens	291-294
34544266-10	2021	NAC/AAP also improved the population doubling time of MSCs (first 6-days post isolation) and significantly downregulated the expression of 2 genes (Nox1 and Rag2) associated with oxidative stress compared to placebo treatment.	ascorbate-2-phosphate	4-7	NADPH oxidase 1	Mus musculus	148-152
34544266-10	2021	NAC/AAP also improved the population doubling time of MSCs (first 6-days post isolation) and significantly downregulated the expression of 2 genes (Nox1 and Rag2) associated with oxidative stress compared to placebo treatment.	ascorbate-2-phosphate	4-7	recombination activating gene 2	Mus musculus	157-161
7965212-1	1994	L-Ascorbic acid 2-phosphate (Asc-P: a stable ascorbic acid derivative) markedly stimulated synthesis of marker proteins for osteoblastic differentiation such as alkaline phosphatase and osteocalcin in a murine osteoblastic cell line, MC3T3-E1, suggesting that Asc-P could promote osteoblastic differentiation.	ascorbate-2-phosphate	0-27	bone gamma-carboxyglutamate protein 2	Mus musculus	186-197
7965212-1	1994	L-Ascorbic acid 2-phosphate (Asc-P: a stable ascorbic acid derivative) markedly stimulated synthesis of marker proteins for osteoblastic differentiation such as alkaline phosphatase and osteocalcin in a murine osteoblastic cell line, MC3T3-E1, suggesting that Asc-P could promote osteoblastic differentiation.	ascorbate-2-phosphate	0-27	steroid sulfatase	Mus musculus	29-32
8123041-0	1994	A long-lasting vitamin C derivative, ascorbic acid 2-phosphate, increases myogenin gene expression and promotes differentiation in L6 muscle cells.	ascorbate-2-phosphate	37-62	myogenin	Homo sapiens	74-82
8123041-3	1994	We now show the effect of L-ascorbic acid 2-phosphate on the kinetics of myogenin expression at both the mRNA and protein levels during differentiation of L6 muscle cells.	ascorbate-2-phosphate	26-53	myogenin	Homo sapiens	73-81
8123041-6	1994	L-ascorbic acid 2-phosphate treated cells expressed a higher amount of myogenin at both the mRNA and protein levels on day 4 compared to untreated cultures.	ascorbate-2-phosphate	0-27	myogenin	Homo sapiens	71-79
8123041-7	1994	Ethyl-3,4-dihydroxybenzoate, an inhibitor of collagen synthesis, prevented expression of myogenin mRNA and protein in both the control and L-ascorbic acid 2-phosphate treated cells.	ascorbate-2-phosphate	139-166	myogenin	Homo sapiens	89-97
8482361-1	1993	L-Ascorbic acid 2-phosphate (Asc 2-P), a long-acting vitamin C derivative, stimulated transcription of genes for pro alpha 1(I) and pro alpha 2(I) collagen in normal human skin fibroblasts after 8 h of treatment in the absence or in the presence of cycloheximide, indicating Asc 2-P stimulates transcription of type I collagen genes in the absence of protein synthesis.	ascorbate-2-phosphate	0-27	pyrin domain containing 1	Homo sapiens	29-34
8482361-1	1993	L-Ascorbic acid 2-phosphate (Asc 2-P), a long-acting vitamin C derivative, stimulated transcription of genes for pro alpha 1(I) and pro alpha 2(I) collagen in normal human skin fibroblasts after 8 h of treatment in the absence or in the presence of cycloheximide, indicating Asc 2-P stimulates transcription of type I collagen genes in the absence of protein synthesis.	ascorbate-2-phosphate	0-27	collagen type I alpha 2 chain	Homo sapiens	136-155
8482361-1	1993	L-Ascorbic acid 2-phosphate (Asc 2-P), a long-acting vitamin C derivative, stimulated transcription of genes for pro alpha 1(I) and pro alpha 2(I) collagen in normal human skin fibroblasts after 8 h of treatment in the absence or in the presence of cycloheximide, indicating Asc 2-P stimulates transcription of type I collagen genes in the absence of protein synthesis.	ascorbate-2-phosphate	0-27	pyrin domain containing 1	Homo sapiens	275-280
34791532-4	2021	After the sandwich immunoreactions were accomplished, the alkaline phosphatase (ALP) hydrolyzed L-ascorbic acid 2-phosphate (AAP) to form ascorbic acid (AA) that further reduces Ag+ and Cu2+ to Ag NPs and Cu+, respectively.	ascorbate-2-phosphate	96-123	serpin family F member 2	Homo sapiens	125-128
34308636-3	2021	Whereas Alb interacts with the bromocresol green (BCG) indicator to form a bluish-green complex, ALP hydrolyzes l-ascorbic acid-2-phosphate (AAP) to produce ascorbic acid (AA), which reacts with KIO3 to generate I2 and I-.	ascorbate-2-phosphate	112-139	alkaline phosphatase, placental	Homo sapiens	97-100
34215060-4	2021	Initially, the immunoreaction was carried out on the 96-well plates in which alkaline phosphatase (ALP) could catalyze ascorbic acid 2-phosphate (AAP) to generate the signal-reporting species ascorbic acid (AA).	ascorbate-2-phosphate	119-144	alkaline phosphatase, placental	Homo sapiens	77-97
34215060-4	2021	Initially, the immunoreaction was carried out on the 96-well plates in which alkaline phosphatase (ALP) could catalyze ascorbic acid 2-phosphate (AAP) to generate the signal-reporting species ascorbic acid (AA).	ascorbate-2-phosphate	119-144	alkaline phosphatase, placental	Homo sapiens	99-102
34215060-4	2021	Initially, the immunoreaction was carried out on the 96-well plates in which alkaline phosphatase (ALP) could catalyze ascorbic acid 2-phosphate (AAP) to generate the signal-reporting species ascorbic acid (AA).	ascorbate-2-phosphate	146-149	alkaline phosphatase, placental	Homo sapiens	77-97
34215060-4	2021	Initially, the immunoreaction was carried out on the 96-well plates in which alkaline phosphatase (ALP) could catalyze ascorbic acid 2-phosphate (AAP) to generate the signal-reporting species ascorbic acid (AA).	ascorbate-2-phosphate	146-149	alkaline phosphatase, placental	Homo sapiens	99-102
34515710-4	2021	Next, AAP was catalyzed by ALP to generate ascorbic acid (AA), which is an efficient electron donor for CdS QDs under illumination.	ascorbate-2-phosphate	6-9	alkaline phosphatase, placental	Homo sapiens	27-30
34308636-3	2021	Whereas Alb interacts with the bromocresol green (BCG) indicator to form a bluish-green complex, ALP hydrolyzes l-ascorbic acid-2-phosphate (AAP) to produce ascorbic acid (AA), which reacts with KIO3 to generate I2 and I-.	ascorbate-2-phosphate	141-144	alkaline phosphatase, placental	Homo sapiens	97-100
34297532-3	2021	As a kind of hydrolysis enzyme, ALP can promote the hydrolysis of l-ascorbic acid 2-phosphate to ascorbic acid (AA).	ascorbate-2-phosphate	66-93	alkaline phosphatase, placental	Homo sapiens	32-35
34291635-5	2021	With the participation of alkaline phosphatase (ALP) labeled on Au NPs-DNA, ascorbic acid 2-phosphate was catalyzed to produce ascorbic acid as an electron donor, resulting in the enhancement of the PEC signal.	ascorbate-2-phosphate	76-101	alkaline phosphatase, placental	Homo sapiens	26-46
34291635-5	2021	With the participation of alkaline phosphatase (ALP) labeled on Au NPs-DNA, ascorbic acid 2-phosphate was catalyzed to produce ascorbic acid as an electron donor, resulting in the enhancement of the PEC signal.	ascorbate-2-phosphate	76-101	alkaline phosphatase, placental	Homo sapiens	48-51
33175189-2	2020	In the presence of ALP, ascorbic acid 2-phosphate (AAP) can be catalyzed to produce ascorbic acid (AA).	ascorbate-2-phosphate	24-49	alkaline phosphatase, placental	Homo sapiens	19-22
35549161-6	2022	These properties were exploited to devise a new biosensing system based on a cascade of reactions catalyzed by the nanozyme (ABTS oxidation) and an enzyme, the alkaline phosphatase (or ALP, ascorbic acid 2-phosphate dephosphorylation).	ascorbate-2-phosphate	190-215	alkaline phosphatase, placental	Homo sapiens	185-188
35486137-3	2022	In our design, ALP can promote the dephosphorylation of l-ascorbic acid 2-phosphate (AAP) to reduce ascorbic acid (AA), which is then able to decompose CoOOH in a nucleic acids@CoOOH nanocomplex into Co2+ cofactors.	ascorbate-2-phosphate	56-83	alkaline phosphatase, placental	Homo sapiens	15-18
35486137-3	2022	In our design, ALP can promote the dephosphorylation of l-ascorbic acid 2-phosphate (AAP) to reduce ascorbic acid (AA), which is then able to decompose CoOOH in a nucleic acids@CoOOH nanocomplex into Co2+ cofactors.	ascorbate-2-phosphate	85-88	alkaline phosphatase, placental	Homo sapiens	15-18
34996003-5	2022	The modified ALP could catalytically convert ascorbic acid-2-phosphate to AA, which was then analyzed by OPECT.	ascorbate-2-phosphate	45-70	alkaline phosphatase, placental	Homo sapiens	13-16
35063488-5	2022	The dual functional Nb-C4bpalpha-AP can recognize AFP, dephosphorylate ascorbic acid-2-phosphate (AAP) into ascorbic acid (AA), and thus tune the MnFe LDH-mediated ratiometric fluorescence, which was generated from the oxidization of MnFe LDH on o-phenylenediamine (OPD) and the catalyzation of MnFe LDH on the cyclization reaction between AA and OPD.	ascorbate-2-phosphate	71-96	complement component 4 binding protein alpha	Homo sapiens	23-32
35063488-5	2022	The dual functional Nb-C4bpalpha-AP can recognize AFP, dephosphorylate ascorbic acid-2-phosphate (AAP) into ascorbic acid (AA), and thus tune the MnFe LDH-mediated ratiometric fluorescence, which was generated from the oxidization of MnFe LDH on o-phenylenediamine (OPD) and the catalyzation of MnFe LDH on the cyclization reaction between AA and OPD.	ascorbate-2-phosphate	98-101	complement component 4 binding protein alpha	Homo sapiens	23-32
33512133-3	2021	This platform is relied on the dephosphorylation of ascorbic acid 2-phosphate (AA2P) by alkaline phosphatase (ALP).	ascorbate-2-phosphate	52-77	alkaline phosphatase, placental	Homo sapiens	88-108
33512133-3	2021	This platform is relied on the dephosphorylation of ascorbic acid 2-phosphate (AA2P) by alkaline phosphatase (ALP).	ascorbate-2-phosphate	52-77	alkaline phosphatase, placental	Homo sapiens	110-113
33498154-4	2021	Ascorbic acid 2-phosphate (AAP), which is the enzyme substrate, is hydrolyzed to produce ascorbic acid (AA) by ALP.	ascorbate-2-phosphate	0-25	alkaline phosphatase, placental	Homo sapiens	111-114
33498154-4	2021	Ascorbic acid 2-phosphate (AAP), which is the enzyme substrate, is hydrolyzed to produce ascorbic acid (AA) by ALP.	ascorbate-2-phosphate	27-30	alkaline phosphatase, placental	Homo sapiens	111-114
35057925-5	2022	The emission intensity of M-SiO2@NAC-CuNCs was significantly decreased in the presence of MnO2 nanosheets by inner filter effect (IFE), and then recovered by ascorbic acid generated by the enzymolysis of l-ascorbic acid-2-phosphate (AAP) in the presence of acid phosphatase (ACP).	ascorbate-2-phosphate	204-231	synuclein alpha	Homo sapiens	33-36
35057925-5	2022	The emission intensity of M-SiO2@NAC-CuNCs was significantly decreased in the presence of MnO2 nanosheets by inner filter effect (IFE), and then recovered by ascorbic acid generated by the enzymolysis of l-ascorbic acid-2-phosphate (AAP) in the presence of acid phosphatase (ACP).	ascorbate-2-phosphate	233-236	synuclein alpha	Homo sapiens	33-36
2910890-1	1989	Proliferation of human skin fibroblasts was stimulated significantly by the presence of L-ascorbic acid 2-phosphate (Asc 2-P).	ascorbate-2-phosphate	88-115	pyrin domain containing 1	Homo sapiens	117-122
34043331-6	2021	Furthermore, abundant electron donors can be obtained by catalyzing AAP with alkaline phosphatase (ALP).	ascorbate-2-phosphate	68-71	alkaline phosphatase, placental	Homo sapiens	77-97
34043331-6	2021	Furthermore, abundant electron donors can be obtained by catalyzing AAP with alkaline phosphatase (ALP).	ascorbate-2-phosphate	68-71	alkaline phosphatase, placental	Homo sapiens	99-102
33742255-4	2021	However, alkaline phosphatase can catalyze the hydrolysis of L-ascorbic acid-2-phosphate to produce ascorbic acid which can reduce the oxTMB to TMB, resulting in an obvious color fading.	ascorbate-2-phosphate	61-88	alkaline phosphatase, placental	Homo sapiens	9-29
33516375-5	2021	On this basis, by using ascorbic acid 2-phosphate as a substrate of ALP, which can be hydrolyzed by ALP to produce AA, the gel-sol transition process of RhB@Alg/Fe3+ was further modulated by ALP.	ascorbate-2-phosphate	24-49	alkaline phosphatase, placental	Homo sapiens	68-71
33516375-5	2021	On this basis, by using ascorbic acid 2-phosphate as a substrate of ALP, which can be hydrolyzed by ALP to produce AA, the gel-sol transition process of RhB@Alg/Fe3+ was further modulated by ALP.	ascorbate-2-phosphate	24-49	alkaline phosphatase, placental	Homo sapiens	100-103
33516375-5	2021	On this basis, by using ascorbic acid 2-phosphate as a substrate of ALP, which can be hydrolyzed by ALP to produce AA, the gel-sol transition process of RhB@Alg/Fe3+ was further modulated by ALP.	ascorbate-2-phosphate	24-49	alkaline phosphatase, placental	Homo sapiens	100-103
33502402-3	2021	In the presence of ACP, l-ascorbic acid 2-phosphate (AAP) can be converted into ascorbic acid (AA), which can reduce Ag+ to Ag0 and format the Au@Ag core-shell nanostructure.	ascorbate-2-phosphate	24-51	serpin family F member 2	Homo sapiens	53-56
33175189-2	2020	In the presence of ALP, ascorbic acid 2-phosphate (AAP) can be catalyzed to produce ascorbic acid (AA).	ascorbate-2-phosphate	51-54	alkaline phosphatase, placental	Homo sapiens	19-22
32203832-5	2020	After magnetic separation, cDNA-ALP catalyzed the decomposition of ascorbic acid 2-phosphate to ascorbic acid that reduced Ag+, forming an Ag shell on the surface of AuNRs.	ascorbate-2-phosphate	67-92	alkaline phosphatase, placental	Homo sapiens	32-35
32323314-9	2020	RESULTS: The results showed that SAP at concentrations from 50 to 500 micromol/L does not influence preosteoblast cell viability, but stimulates their differentiation, observed by the induction of RUNX2, COL1A1, and BGLAP2; by the higher secreted levels of collagen I; and also by the increase in the mineralization of the extracellular matrix in cells exposed to this agent at 200 or 400 micromol/L, compared with those not exposed.	ascorbate-2-phosphate	33-36	runt related transcription factor 2	Mus musculus	197-202
32323314-9	2020	RESULTS: The results showed that SAP at concentrations from 50 to 500 micromol/L does not influence preosteoblast cell viability, but stimulates their differentiation, observed by the induction of RUNX2, COL1A1, and BGLAP2; by the higher secreted levels of collagen I; and also by the increase in the mineralization of the extracellular matrix in cells exposed to this agent at 200 or 400 micromol/L, compared with those not exposed.	ascorbate-2-phosphate	33-36	collagen, type I, alpha 1	Mus musculus	204-210
32323314-9	2020	RESULTS: The results showed that SAP at concentrations from 50 to 500 micromol/L does not influence preosteoblast cell viability, but stimulates their differentiation, observed by the induction of RUNX2, COL1A1, and BGLAP2; by the higher secreted levels of collagen I; and also by the increase in the mineralization of the extracellular matrix in cells exposed to this agent at 200 or 400 micromol/L, compared with those not exposed.	ascorbate-2-phosphate	33-36	bone gamma-carboxyglutamate protein 2	Mus musculus	216-222
32940263-3	2020	Thus the fluorescence signal of the CNNS-Ag+ system is extremely weak even in the presence of l-ascorbic acid-2-phosphate (AAP) ("off" state).	ascorbate-2-phosphate	94-121	serpin family F member 2	Homo sapiens	123-126
32090638-2	2020	Then, we investigated the impacts of UVA irradiation and Ascorbic acid-2-phosphate (Asc-2p) on the wound healing process of the in vitro HCEnC model by examining wound-healing index, F-actin+ rate, Ki-67+ rate, and ROS production.Results: After scratching, the Ki-67+ and F-actin+ HCEnCs occupied the scratching gap.	ascorbate-2-phosphate	57-82	pyrin domain containing 1	Homo sapiens	84-90
31883584-5	2020	However, with the presence of AA, hydrolyzed from L-ascorbic-2-phosphate (AAP) by ACP, the MnO2 nanosheets in Au-NCs/MnO2 nanocomposite were reduced to Mn2+ immediately.	ascorbate-2-phosphate	50-72	serpin family F member 2	Homo sapiens	74-77
31796354-2	2020	In the presence of ALP, the substrate ascorbic acid 2-phosphate was hydrolyzed to generate ascorbic acid (AA).	ascorbate-2-phosphate	38-63	alkaline phosphatase, placental	Homo sapiens	19-22
31627810-3	2019	Meanwhile, in the presence of both alkaline phosphatase (ALP) and ascorbyl-2-phosphate (AAP), the fluorescence of N-CDs can also restore since AAP can be hydrolyzed into AA by ALP.	ascorbate-2-phosphate	66-86	alkaline phosphatase, placental	Homo sapiens	176-179
31816768-5	2020	Under the optimized parameters (500 nM DNA probe; 6 muM Ag+; 1 mM AAP; 30 min for Ag+ and DNA probe reaction time), fluorescence intensity correlates linear range between 1 and 100 U/L of ALP concentration with the detection limit of 0.503 U/L.	ascorbate-2-phosphate	66-69	alkaline phosphatase, placental	Homo sapiens	188-191
31864616-4	2020	Secondly, when in the presence of ALP, l-ascorbic acid 2-phosphate (AAP) was transformed into ascorbic acid (AA) which can react with KIO3 to produce I2.	ascorbate-2-phosphate	68-71	alkaline phosphatase, placental	Homo sapiens	34-37
31864616-4	2020	Secondly, when in the presence of ALP, l-ascorbic acid 2-phosphate (AAP) was transformed into ascorbic acid (AA) which can react with KIO3 to produce I2.	ascorbate-2-phosphate	68-71	serpin family F member 2	Homo sapiens	39-66
31816768-3	2020	In the presence of ALP, ascorbic acid 2-phosphate (AAP) is hydrolyzed to form ascorbic acid (AA) which in turn reduces Ag+ to Ag0.	ascorbate-2-phosphate	24-49	alkaline phosphatase, placental	Homo sapiens	19-22
31816768-3	2020	In the presence of ALP, ascorbic acid 2-phosphate (AAP) is hydrolyzed to form ascorbic acid (AA) which in turn reduces Ag+ to Ag0.	ascorbate-2-phosphate	51-54	alkaline phosphatase, placental	Homo sapiens	19-22
31912851-7	2020	With the assistance of alkaline phosphatase (ALP), the activity of ALP can be monitored using the ratiometric platform based on the hydrolyzing ascorbic acid 2-phosphate to yield AA with the detection limit of 0.16 mU mL-1.	ascorbate-2-phosphate	144-169	alkaline phosphatase, placental	Homo sapiens	23-43
31912851-7	2020	With the assistance of alkaline phosphatase (ALP), the activity of ALP can be monitored using the ratiometric platform based on the hydrolyzing ascorbic acid 2-phosphate to yield AA with the detection limit of 0.16 mU mL-1.	ascorbate-2-phosphate	144-169	alkaline phosphatase, placental	Homo sapiens	45-48
31912851-7	2020	With the assistance of alkaline phosphatase (ALP), the activity of ALP can be monitored using the ratiometric platform based on the hydrolyzing ascorbic acid 2-phosphate to yield AA with the detection limit of 0.16 mU mL-1.	ascorbate-2-phosphate	144-169	alkaline phosphatase, placental	Homo sapiens	67-70
31171195-7	2019	Owing to the alkaline phosphatase (ALP) can catalyze the hydrolysis of AA 2-phosphate (AAP) into AA, ALP can also be quantified by the above method.	ascorbate-2-phosphate	71-85	alkaline phosphatase, placental	Homo sapiens	13-33
31655858-7	2019	In a typical enzymatic reaction, ascorbic acid 2-phosphate is hydrolyzed by ALP to produce ascorbic acid.	ascorbate-2-phosphate	33-58	alkaline phosphatase, placental	Homo sapiens	76-79
31171195-7	2019	Owing to the alkaline phosphatase (ALP) can catalyze the hydrolysis of AA 2-phosphate (AAP) into AA, ALP can also be quantified by the above method.	ascorbate-2-phosphate	71-85	alkaline phosphatase, placental	Homo sapiens	35-38
31171195-7	2019	Owing to the alkaline phosphatase (ALP) can catalyze the hydrolysis of AA 2-phosphate (AAP) into AA, ALP can also be quantified by the above method.	ascorbate-2-phosphate	71-85	alkaline phosphatase, placental	Homo sapiens	101-104
31171195-7	2019	Owing to the alkaline phosphatase (ALP) can catalyze the hydrolysis of AA 2-phosphate (AAP) into AA, ALP can also be quantified by the above method.	ascorbate-2-phosphate	87-90	alkaline phosphatase, placental	Homo sapiens	13-33
31171195-7	2019	Owing to the alkaline phosphatase (ALP) can catalyze the hydrolysis of AA 2-phosphate (AAP) into AA, ALP can also be quantified by the above method.	ascorbate-2-phosphate	87-90	alkaline phosphatase, placental	Homo sapiens	35-38
31171195-7	2019	Owing to the alkaline phosphatase (ALP) can catalyze the hydrolysis of AA 2-phosphate (AAP) into AA, ALP can also be quantified by the above method.	ascorbate-2-phosphate	87-90	alkaline phosphatase, placental	Homo sapiens	101-104
31121436-6	2019	In the absence of T-DNA, the triple-helix molecule was in a closed state and the ALP of ALP-Au NPs-DNA could specifically catalyze the ascorbic acid 2-phosphate (AAP) to generate ascorbic acid (AA) as electron donors, which resulted in a significant photocurrent response due to the rapid electron transfer process.	ascorbate-2-phosphate	135-160	ATHS	Homo sapiens	81-84
31121436-6	2019	In the absence of T-DNA, the triple-helix molecule was in a closed state and the ALP of ALP-Au NPs-DNA could specifically catalyze the ascorbic acid 2-phosphate (AAP) to generate ascorbic acid (AA) as electron donors, which resulted in a significant photocurrent response due to the rapid electron transfer process.	ascorbate-2-phosphate	135-160	ATHS	Homo sapiens	88-91
31183571-4	2019	In the presence of ALP and its substrate ascorbic acid-2-phosphate, the latter is hydrolyzed to form ascorbic acid (AA).	ascorbate-2-phosphate	41-66	alkaline phosphatase, placental	Homo sapiens	19-22
31121436-6	2019	In the absence of T-DNA, the triple-helix molecule was in a closed state and the ALP of ALP-Au NPs-DNA could specifically catalyze the ascorbic acid 2-phosphate (AAP) to generate ascorbic acid (AA) as electron donors, which resulted in a significant photocurrent response due to the rapid electron transfer process.	ascorbate-2-phosphate	162-165	ATHS	Homo sapiens	81-84
31121436-6	2019	In the absence of T-DNA, the triple-helix molecule was in a closed state and the ALP of ALP-Au NPs-DNA could specifically catalyze the ascorbic acid 2-phosphate (AAP) to generate ascorbic acid (AA) as electron donors, which resulted in a significant photocurrent response due to the rapid electron transfer process.	ascorbate-2-phosphate	162-165	ATHS	Homo sapiens	88-91
31121436-7	2019	However, in the presence of T-DNA, the T-DNA hybridized with the ALP-Au NPs-DNA molecule, which caused triple-helix molecule in an opened state and compelled ALP-Au NPs-DNA away from the electrode surface, resulting in the absence of ALP which could catalyze AAP to generate AA.	ascorbate-2-phosphate	259-262	ATHS	Homo sapiens	65-68
31121436-7	2019	However, in the presence of T-DNA, the T-DNA hybridized with the ALP-Au NPs-DNA molecule, which caused triple-helix molecule in an opened state and compelled ALP-Au NPs-DNA away from the electrode surface, resulting in the absence of ALP which could catalyze AAP to generate AA.	ascorbate-2-phosphate	259-262	ATHS	Homo sapiens	158-161
31121436-7	2019	However, in the presence of T-DNA, the T-DNA hybridized with the ALP-Au NPs-DNA molecule, which caused triple-helix molecule in an opened state and compelled ALP-Au NPs-DNA away from the electrode surface, resulting in the absence of ALP which could catalyze AAP to generate AA.	ascorbate-2-phosphate	259-262	ATHS	Homo sapiens	158-161
31357457-5	2019	Another clinical study using a tyrosinase inhibitor L-ascorbate-2-phosphate 3 Na (ASP) demonstrated that L values of test lotion (6% APS)-treated skin significantly increased in SLs and in non-lesional skin with a significantly higher DeltaL value in SLs when compared with non-lesional skin.	ascorbate-2-phosphate	52-75	tyrosinase	Homo sapiens	31-41
31197585-3	2019	ALP specifically catalyzes the hydrolysis of ascorbic acid-2-phosphate to produce ascorbic acid which reduces CoOOH nanoflakes to Co(II) ion.	ascorbate-2-phosphate	45-70	alkaline phosphatase, placental	Homo sapiens	0-3
31197585-3	2019	ALP specifically catalyzes the hydrolysis of ascorbic acid-2-phosphate to produce ascorbic acid which reduces CoOOH nanoflakes to Co(II) ion.	ascorbate-2-phosphate	45-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
30661613-4	2019	Secondly, ALP catalyzes the hydrolysis of the substrate l-ascorbic acid 2-phosphate (AAP) to ascorbic acid (AA) which can consume part of Ag+ to inhibit the generation of OPDox and the AA was oxidized to dehydroascorbic acid (DHAA).	ascorbate-2-phosphate	56-83	alkaline phosphatase, placental	Homo sapiens	10-13
30685041-4	2019	With the formation of immunocomplex, the carried ALP hydrolyzed ascorbic acid 2-phosphate (AAP) into ascorbic acid (AA) and phosphate.	ascorbate-2-phosphate	64-89	alkaline phosphatase, placental	Homo sapiens	49-52
30685041-4	2019	With the formation of immunocomplex, the carried ALP hydrolyzed ascorbic acid 2-phosphate (AAP) into ascorbic acid (AA) and phosphate.	ascorbate-2-phosphate	91-94	alkaline phosphatase, placental	Homo sapiens	49-52
30661613-4	2019	Secondly, ALP catalyzes the hydrolysis of the substrate l-ascorbic acid 2-phosphate (AAP) to ascorbic acid (AA) which can consume part of Ag+ to inhibit the generation of OPDox and the AA was oxidized to dehydroascorbic acid (DHAA).	ascorbate-2-phosphate	56-83	serpin family F member 2	Homo sapiens	85-88
30659923-1	2019	An innovative lyophilized dry powder formulation consisting of urea-crosslinked hyaluronic acid (HA-CL) and sodium ascorbyl phosphate (SAP) - LYO HA-CL - SAP- was prepared and characterized in vitro for physico-chemical and biological properties.	ascorbate-2-phosphate	108-133	SH2 domain containing 1A	Homo sapiens	135-138
30659923-1	2019	An innovative lyophilized dry powder formulation consisting of urea-crosslinked hyaluronic acid (HA-CL) and sodium ascorbyl phosphate (SAP) - LYO HA-CL - SAP- was prepared and characterized in vitro for physico-chemical and biological properties.	ascorbate-2-phosphate	108-133	SH2 domain containing 1A	Homo sapiens	154-157
30796533-4	2019	On the basis of the boronic acid-triggered specific reaction with cis-diols, the boronic acid modified C-dots can bind to ascorbic acid that is generated by ALP-catalyzed hydrolysis of ascorbic acid 2-phosphate.	ascorbate-2-phosphate	185-210	alkaline phosphatase, placental	Homo sapiens	157-160
30534723-4	2019	Furthermore, by taking advantage of AA as a mediator, this strategy is further exploited for ALP assay given that ALP can cause the hydrolysis of l-ascorbic acid-2-phosphate (AAP), which yields AA.	ascorbate-2-phosphate	175-178	alkaline phosphatase, placental	Homo sapiens	93-96
30688059-1	2019	Inspired by the special reducing capability of ascorbic acid (AA), ascorbic acid 2-phosphate (AA2P) has been extensively utilized as a substrate in current alkaline phosphatase (ALP) activity assays owing to the ALP-triggered transformation of AA2P into AA.	ascorbate-2-phosphate	67-92	alkaline phosphatase, placental	Homo sapiens	156-176
30688059-1	2019	Inspired by the special reducing capability of ascorbic acid (AA), ascorbic acid 2-phosphate (AA2P) has been extensively utilized as a substrate in current alkaline phosphatase (ALP) activity assays owing to the ALP-triggered transformation of AA2P into AA.	ascorbate-2-phosphate	67-92	alkaline phosphatase, placental	Homo sapiens	178-181
30688059-1	2019	Inspired by the special reducing capability of ascorbic acid (AA), ascorbic acid 2-phosphate (AA2P) has been extensively utilized as a substrate in current alkaline phosphatase (ALP) activity assays owing to the ALP-triggered transformation of AA2P into AA.	ascorbate-2-phosphate	67-92	alkaline phosphatase, placental	Homo sapiens	212-215
30534723-4	2019	Furthermore, by taking advantage of AA as a mediator, this strategy is further exploited for ALP assay given that ALP can cause the hydrolysis of l-ascorbic acid-2-phosphate (AAP), which yields AA.	ascorbate-2-phosphate	175-178	alkaline phosphatase, placental	Homo sapiens	114-117
30534723-4	2019	Furthermore, by taking advantage of AA as a mediator, this strategy is further exploited for ALP assay given that ALP can cause the hydrolysis of l-ascorbic acid-2-phosphate (AAP), which yields AA.	ascorbate-2-phosphate	175-178	serpin family F member 2	Homo sapiens	146-173
29523248-4	2018	Take carcinoembryonic antigen (CEA) as a model analyte and alkaline phosphate (ALP) as a catalytic label tracer to hydrolyze ascorbic acid 2-phosphate (AAP) for producing AA, which greatly stimulated the photocurrent of the transducer of KMnO4 treated FTO/TiO2/CDs photoelectrode for signal output.	ascorbate-2-phosphate	125-150	CEA cell adhesion molecule 3	Homo sapiens	5-29
30187827-4	2018	This study investigated the effectiveness of ex vivo antioxidant treatment [N-acetylcysteine (7.5 mM NAC) and Ascorbic acid 2-phosphate (0.6 mM AAP)] to restore the paracrine function of diabetic MSCs.	ascorbate-2-phosphate	110-135	active avoidance performance	Mus musculus	144-147
32254926-4	2018	Upon addition of Kana analyte, target-assisted recycling and the 3WJ-HCR reaction were readily implemented on functional magnetic beads, thus resulting in the assembly of numerous alkaline phosphatase (ALP) molecules through the avidin-biotin interaction, which hydrolyzed ascorbic acid 2-phosphate (AAP) to ascorbic acid (AA).	ascorbate-2-phosphate	273-298	alkaline phosphatase, placental	Homo sapiens	180-200
32254926-4	2018	Upon addition of Kana analyte, target-assisted recycling and the 3WJ-HCR reaction were readily implemented on functional magnetic beads, thus resulting in the assembly of numerous alkaline phosphatase (ALP) molecules through the avidin-biotin interaction, which hydrolyzed ascorbic acid 2-phosphate (AAP) to ascorbic acid (AA).	ascorbate-2-phosphate	273-298	alkaline phosphatase, placental	Homo sapiens	202-205
32254926-4	2018	Upon addition of Kana analyte, target-assisted recycling and the 3WJ-HCR reaction were readily implemented on functional magnetic beads, thus resulting in the assembly of numerous alkaline phosphatase (ALP) molecules through the avidin-biotin interaction, which hydrolyzed ascorbic acid 2-phosphate (AAP) to ascorbic acid (AA).	ascorbate-2-phosphate	300-303	alkaline phosphatase, placental	Homo sapiens	180-200
32254926-4	2018	Upon addition of Kana analyte, target-assisted recycling and the 3WJ-HCR reaction were readily implemented on functional magnetic beads, thus resulting in the assembly of numerous alkaline phosphatase (ALP) molecules through the avidin-biotin interaction, which hydrolyzed ascorbic acid 2-phosphate (AAP) to ascorbic acid (AA).	ascorbate-2-phosphate	300-303	alkaline phosphatase, placental	Homo sapiens	202-205
30051195-0	2018	Fluorometric turn-on determination of the activity of alkaline phosphatase by using WS2 quantum dots and enzymatic cleavage of ascorbic acid 2-phosphate.	ascorbate-2-phosphate	127-152	alkaline phosphatase, placental	Homo sapiens	54-74
30051195-4	2018	The detection scheme relies on the fact that ALP hydrolyzes the substrate ascorbic acid 2-phosphate to produce AA, and that enzymatically generated AA can restore the fluorescence of the QDs.	ascorbate-2-phosphate	74-99	alkaline phosphatase, placental	Homo sapiens	45-48
30051195-7	2018	Graphical abstract The fluorescence of chromate-loaded tungsten disulfide quantum dots (QDs) is quenched but restored after reaction with ascorbic acid that is formed by the catalytic action of alkaline phosphatase (ALP) on ascorbic acid 2-phosphate (AAP).	ascorbate-2-phosphate	224-249	alkaline phosphatase, placental	Homo sapiens	194-214
30051195-7	2018	Graphical abstract The fluorescence of chromate-loaded tungsten disulfide quantum dots (QDs) is quenched but restored after reaction with ascorbic acid that is formed by the catalytic action of alkaline phosphatase (ALP) on ascorbic acid 2-phosphate (AAP).	ascorbate-2-phosphate	224-249	alkaline phosphatase, placental	Homo sapiens	216-219
30051195-7	2018	Graphical abstract The fluorescence of chromate-loaded tungsten disulfide quantum dots (QDs) is quenched but restored after reaction with ascorbic acid that is formed by the catalytic action of alkaline phosphatase (ALP) on ascorbic acid 2-phosphate (AAP).	ascorbate-2-phosphate	251-254	alkaline phosphatase, placental	Homo sapiens	194-214
30051195-7	2018	Graphical abstract The fluorescence of chromate-loaded tungsten disulfide quantum dots (QDs) is quenched but restored after reaction with ascorbic acid that is formed by the catalytic action of alkaline phosphatase (ALP) on ascorbic acid 2-phosphate (AAP).	ascorbate-2-phosphate	251-254	alkaline phosphatase, placental	Homo sapiens	216-219
29523248-4	2018	Take carcinoembryonic antigen (CEA) as a model analyte and alkaline phosphate (ALP) as a catalytic label tracer to hydrolyze ascorbic acid 2-phosphate (AAP) for producing AA, which greatly stimulated the photocurrent of the transducer of KMnO4 treated FTO/TiO2/CDs photoelectrode for signal output.	ascorbate-2-phosphate	125-150	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	252-255
29523248-4	2018	Take carcinoembryonic antigen (CEA) as a model analyte and alkaline phosphate (ALP) as a catalytic label tracer to hydrolyze ascorbic acid 2-phosphate (AAP) for producing AA, which greatly stimulated the photocurrent of the transducer of KMnO4 treated FTO/TiO2/CDs photoelectrode for signal output.	ascorbate-2-phosphate	152-155	CEA cell adhesion molecule 3	Homo sapiens	5-29
29523248-4	2018	Take carcinoembryonic antigen (CEA) as a model analyte and alkaline phosphate (ALP) as a catalytic label tracer to hydrolyze ascorbic acid 2-phosphate (AAP) for producing AA, which greatly stimulated the photocurrent of the transducer of KMnO4 treated FTO/TiO2/CDs photoelectrode for signal output.	ascorbate-2-phosphate	152-155	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	252-255
29384352-3	2018	By means of the ALP-triggered generation of ascorbic acid (AA) from the substrate ascorbic acid 2-phosphate, the AA-triggered reduction of MnO2 nanosheets to Mn2+, as well as the clear quenching mechanism of F-PDA nanoparticles by MnO2 nanosheets, we have developed a label-free, low-cost, visual, and facile synthetic fluorescent biosensor for convenient assay of ALP activity.	ascorbate-2-phosphate	82-107	alkaline phosphatase, placental	Homo sapiens	16-19
29673351-3	2018	METHODS: Using siRNA, FKBP10 expression was inhibited in phLF in absence or presence of 2ng/ml transforming growth factor-beta1 (TGF-beta1) and 0.1mM 2-phosphoascorbate.	ascorbate-2-phosphate	150-168	FKBP prolyl isomerase 10	Homo sapiens	22-28
29666467-3	2018	Supplementation of 250 muM L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate (AA2P) during in vitro maturation significantly enhanced the nuclear maturation (as indicated by higher rate of first polar body extrusion and increased Bmp15 mRNA level), reduced level of reactive oxygen species, and promoted developmental potency (higher cleavage and blastocyst rates of parthenotes, and decreased Bax and Caspase3 mRNA levels in blastocysts) of pig oocytes.	ascorbate-2-phosphate	27-54	bone morphogenetic protein 15	Sus scrofa	237-242
29666467-3	2018	Supplementation of 250 muM L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate (AA2P) during in vitro maturation significantly enhanced the nuclear maturation (as indicated by higher rate of first polar body extrusion and increased Bmp15 mRNA level), reduced level of reactive oxygen species, and promoted developmental potency (higher cleavage and blastocyst rates of parthenotes, and decreased Bax and Caspase3 mRNA levels in blastocysts) of pig oocytes.	ascorbate-2-phosphate	27-54	apoptosis regulator BAX	Sus scrofa	401-404
29666467-3	2018	Supplementation of 250 muM L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate (AA2P) during in vitro maturation significantly enhanced the nuclear maturation (as indicated by higher rate of first polar body extrusion and increased Bmp15 mRNA level), reduced level of reactive oxygen species, and promoted developmental potency (higher cleavage and blastocyst rates of parthenotes, and decreased Bax and Caspase3 mRNA levels in blastocysts) of pig oocytes.	ascorbate-2-phosphate	27-54	caspase 3	Sus scrofa	409-417
29594735-2	2018	Alkaline phosphatase (ALP) catalyzes the hydrolysis of ascorbic acid 2-phosphate to release free ascorbic acid which undergoes an in-situ redox reaction with KMnO4.	ascorbate-2-phosphate	55-80	alkaline phosphatase, placental	Homo sapiens	0-20
29594735-2	2018	Alkaline phosphatase (ALP) catalyzes the hydrolysis of ascorbic acid 2-phosphate to release free ascorbic acid which undergoes an in-situ redox reaction with KMnO4.	ascorbate-2-phosphate	55-80	alkaline phosphatase, placental	Homo sapiens	22-25
32254237-6	2018	Alkaline phosphatase (ALP) can make l-ascorbic acid-2-phosphate (AAP) hydrolyze to yield AA.	ascorbate-2-phosphate	36-63	alkaline phosphatase, placental	Homo sapiens	0-20
32254237-6	2018	Alkaline phosphatase (ALP) can make l-ascorbic acid-2-phosphate (AAP) hydrolyze to yield AA.	ascorbate-2-phosphate	36-63	alkaline phosphatase, placental	Homo sapiens	22-25
32254237-6	2018	Alkaline phosphatase (ALP) can make l-ascorbic acid-2-phosphate (AAP) hydrolyze to yield AA.	ascorbate-2-phosphate	65-68	alkaline phosphatase, placental	Homo sapiens	0-20
32254237-6	2018	Alkaline phosphatase (ALP) can make l-ascorbic acid-2-phosphate (AAP) hydrolyze to yield AA.	ascorbate-2-phosphate	65-68	alkaline phosphatase, placental	Homo sapiens	22-25
32254237-7	2018	As a result, with the help of AAP, the selective and sensitive dual-mode assay of ALP activity has been realized successfully by using fluorescence and UV-vis absorption spectroscopies.	ascorbate-2-phosphate	30-33	alkaline phosphatase, placental	Homo sapiens	82-85
29594735-9	2018	The method is based on the in-situ regulation of the formation of fluorescent polydopamine nanodots (PDA-NDs) through the competition between the KMnO4-induced polymerization of dopamine and ALP-directed ascorbic acid 2-phosphate (Asc-2P) hydrolysis.	ascorbate-2-phosphate	204-229	alkaline phosphatase, placental	Homo sapiens	191-194
29256077-4	2018	The fluorescence of VS2 quantum dots quenched by Fe3+ can be restored by ascorbic acid, which is generated by hydrolysis of L-ascorbic acid 2-phosphate catalyzed by ALP.	ascorbate-2-phosphate	124-151	alkaline phosphatase, placental	Homo sapiens	165-168
29594450-5	2018	AA is formed in-situ by hydrolysis of the substrate ascorbic acid 2-phosphate (AA2P) as catalyzed by ALP.	ascorbate-2-phosphate	52-77	alkaline phosphatase, placental	Homo sapiens	101-104
28763784-6	2018	Upon addition of tween 20, the ALP molecules were released and catalyzed the hydrolysis of ascorbic acid 2-phosphate (AA-p) to produce ascorbic acid (AA).	ascorbate-2-phosphate	91-116	alkaline phosphatase, placental	Homo sapiens	31-34
28763784-6	2018	Upon addition of tween 20, the ALP molecules were released and catalyzed the hydrolysis of ascorbic acid 2-phosphate (AA-p) to produce ascorbic acid (AA).	ascorbate-2-phosphate	118-122	alkaline phosphatase, placental	Homo sapiens	31-34
29594450-5	2018	AA is formed in-situ by hydrolysis of the substrate ascorbic acid 2-phosphate (AA2P) as catalyzed by ALP.	ascorbate-2-phosphate	79-83	alkaline phosphatase, placental	Homo sapiens	101-104
29594450-12	2018	ALP catalyzes hydrolysis of ascorbic acid 2-phosphate (AA2P) and dephosphorylation to form AA.	ascorbate-2-phosphate	28-53	alkaline phosphatase, placental	Homo sapiens	0-3
29526903-3	2018	In the presence of ALP, the substrate ascorbic acid 2-phosphate (AAP) can be enzymatically hydrolyzed to release ascorbic acid (AA), which in turn reduces Cu2+ to Cu+.	ascorbate-2-phosphate	38-63	alkaline phosphatase, placental	Homo sapiens	19-22
29526903-3	2018	In the presence of ALP, the substrate ascorbic acid 2-phosphate (AAP) can be enzymatically hydrolyzed to release ascorbic acid (AA), which in turn reduces Cu2+ to Cu+.	ascorbate-2-phosphate	65-68	alkaline phosphatase, placental	Homo sapiens	19-22
27916122-2	2017	In the presence of ALP, the applied substrate ascorbic acid 2-phosphate is enzymatically hydrolyzed to produce ascorbic acid, which then reduces Fe3+ to Fe2+.	ascorbate-2-phosphate	46-71	alkaline phosphatase, placental	Homo sapiens	19-22
28917785-3	2018	Initially, ALP can enzymatically hydrolyze the substrate ascorbic acid 2-phosphate to release ascorbic acid (AA).	ascorbate-2-phosphate	57-82	alkaline phosphatase, placental	Homo sapiens	11-14
26572654-2	2017	Addition of ascorbic acid 2 phosphate (VCP) at a high concentration (250 microg/ml) and type 1 atelocollagen (5 microg/ml) increased the accumulation of type 2 collagen by fourfold and twofold, respectively.	ascorbate-2-phosphate	12-37	valosin containing protein	Homo sapiens	39-42
27657654-4	2016	After adding target antigen, the presence of ALP labeled on antibody catalyzes the transformation of the substrate ascorbic acid 2-phosphate into ascorbic acid.	ascorbate-2-phosphate	115-140	alkaline phosphatase, placental	Homo sapiens	45-48
27615725-3	2016	The presence of ACP or ALP dephosphorylates the substrate ascorbic acid 2-phosphate to produce ascorbic acid, which then reduces Cu(BCDS)22- into Cu(BCDS)23- , leading to a turn-on spectral absorption at 484 nm and a dramatic color change of the solution from colorless to orange-red.	ascorbate-2-phosphate	58-83	alkaline phosphatase, placental	Homo sapiens	23-26
25909282-7	2015	NAC/AAP prevents apoptotic cell death via decreasing the activation of BAX, increasing the expression of BCL2, and reducing cytochrome c release from mitochondria that might lead to the activation of caspase cascade.	ascorbate-2-phosphate	4-7	BCL2 associated X, apoptosis regulator	Homo sapiens	71-74
26841098-2	2016	ALP and AChE were integrated into the PEC system through the sandwich immunobinding and could specifically catalyze the hydrolysis of ascorbic acid 2-phosphate (AAP) or the acetylthiocholine (ATC) to in situ generate ascorbic acid (AA) or thiocholine (TC) for sacrificial electron donating.	ascorbate-2-phosphate	134-159	alkaline phosphatase, placental	Homo sapiens	0-3
26841098-2	2016	ALP and AChE were integrated into the PEC system through the sandwich immunobinding and could specifically catalyze the hydrolysis of ascorbic acid 2-phosphate (AAP) or the acetylthiocholine (ATC) to in situ generate ascorbic acid (AA) or thiocholine (TC) for sacrificial electron donating.	ascorbate-2-phosphate	161-164	alkaline phosphatase, placental	Homo sapiens	0-3
27714143-1	2016	Inspired by the ALP-triggered hydrolysis of the substrate ascorbic acid 2-phosphate as well as the product ascorbate-controlled generation of polyT-CuNPs with bright red fluorescence, we have developed a novel, selective and sensitive fluorescence turn-on assay for ALP activity sensing.	ascorbate-2-phosphate	58-83	ATHS	Homo sapiens	16-19
27714143-1	2016	Inspired by the ALP-triggered hydrolysis of the substrate ascorbic acid 2-phosphate as well as the product ascorbate-controlled generation of polyT-CuNPs with bright red fluorescence, we have developed a novel, selective and sensitive fluorescence turn-on assay for ALP activity sensing.	ascorbate-2-phosphate	58-83	ATHS	Homo sapiens	266-269
27343614-3	2016	ALP can remove the phosphate group in sodium ascorbyl phosphate (SAP), and convert it into reducing ascorbate.	ascorbate-2-phosphate	38-63	alkaline phosphatase, placental	Homo sapiens	0-3
27343614-3	2016	ALP can remove the phosphate group in sodium ascorbyl phosphate (SAP), and convert it into reducing ascorbate.	ascorbate-2-phosphate	65-68	alkaline phosphatase, placental	Homo sapiens	0-3
26964642-7	2016	Interestingly, reductions in ROS generation and apoptosis, and upregulation of miR-223 were found in ADSCs treated with antioxidants NAC and AAP.	ascorbate-2-phosphate	141-144	microRNA 223	Homo sapiens	79-86
26964642-11	2016	These results indicate that NAC and AAP suppress AGE-HSA-induced apoptosis of ADSCs, possibly through downregulation of miR-223.	ascorbate-2-phosphate	36-39	microRNA 223	Homo sapiens	120-127
27807451-3	2016	In this study, we determined whether this low calcium K-NAC medium with antioxidants (N-acetyl-L-cysteine and L-ascorbic acid-2-phosphate) is a better medium to grow human breast epithelial cells.	ascorbate-2-phosphate	110-137	synuclein alpha	Homo sapiens	56-59
26619266-2	2015	Once the sandwich-type immunocomplex is formed, the ALP bound on the polystyrene microwells will hydrolyze ascorbic acid 2-phosphate into ascorbic acid.	ascorbate-2-phosphate	107-132	alkaline phosphatase, placental	Homo sapiens	52-55
26419514-4	2015	In this study, we control redox blinking by adding a reductant ascorbic acid 2-phosphate (VcP), which converts (3) R6G* into the radical anion form R6G(.-) , and by adding a bulky oxidant FeDTPA.	ascorbate-2-phosphate	63-88	valosin containing protein	Homo sapiens	90-93
25909282-7	2015	NAC/AAP prevents apoptotic cell death via decreasing the activation of BAX, increasing the expression of BCL2, and reducing cytochrome c release from mitochondria that might lead to the activation of caspase cascade.	ascorbate-2-phosphate	4-7	BCL2 apoptosis regulator	Homo sapiens	105-109
25909282-7	2015	NAC/AAP prevents apoptotic cell death via decreasing the activation of BAX, increasing the expression of BCL2, and reducing cytochrome c release from mitochondria that might lead to the activation of caspase cascade.	ascorbate-2-phosphate	4-7	cytochrome c, somatic	Homo sapiens	124-136
25356934-5	2014	Thus, through the specific recognition of antigen-antibody, numerous ALP/Fc-Ab2/AuNPs/IL/Gr, which are captured onto every single immunocomplex, could further catalyze the ascorbic acid 2-phosphate (AA-p) reaction to amplify the electrochemical signal.	ascorbate-2-phosphate	172-197	C-C motif chemokine ligand 27	Homo sapiens	69-72
25356934-5	2014	Thus, through the specific recognition of antigen-antibody, numerous ALP/Fc-Ab2/AuNPs/IL/Gr, which are captured onto every single immunocomplex, could further catalyze the ascorbic acid 2-phosphate (AA-p) reaction to amplify the electrochemical signal.	ascorbate-2-phosphate	199-203	C-C motif chemokine ligand 27	Homo sapiens	69-72
25458345-9	2014	The findings suggest the combined addition of BMP-2, BMP-6 and BMP-9 to the osteoinductive culture medium containing dexamethasone, beta-glycerophosphate and ascorbate-2-phosphate produces more potent osteoblast differentiation of human MSCs in vitro.	ascorbate-2-phosphate	158-179	bone morphogenetic protein 2	Homo sapiens	46-51
25458345-9	2014	The findings suggest the combined addition of BMP-2, BMP-6 and BMP-9 to the osteoinductive culture medium containing dexamethasone, beta-glycerophosphate and ascorbate-2-phosphate produces more potent osteoblast differentiation of human MSCs in vitro.	ascorbate-2-phosphate	158-179	bone morphogenetic protein 6	Homo sapiens	53-58
25458345-9	2014	The findings suggest the combined addition of BMP-2, BMP-6 and BMP-9 to the osteoinductive culture medium containing dexamethasone, beta-glycerophosphate and ascorbate-2-phosphate produces more potent osteoblast differentiation of human MSCs in vitro.	ascorbate-2-phosphate	158-179	growth differentiation factor 2	Homo sapiens	63-68
25244147-4	2014	Upon target ALP introduction into the substrate, the ascorbic acid 2-phosphate was hydrolyzed to form ascorbic acid, and then, the generated ascorbic acid reduced silver ion to metal silver and coated on the gold nanorod, thereby resulting in the blue shift of longitudinal localized surface plasmon resonance peak of gold nanorod accompanying a perceptible color change from red to orange to yellow to green to cyan to blue and to violet.	ascorbate-2-phosphate	53-78	alkaline phosphatase, placental	Homo sapiens	12-15
23767049-2	2013	Initially, the carried CeO2 nanoparticles autocatalytically hydrolyzed the phosphate ester bond of l-ascorbic acid 2-phosphate (AAP) to produce a new reactant (l-ascorbic acid, AA), then the generated AA was electrochemically oxidized by the assembled thionine on the Thi-CeO2, and the resultant product was then reduced back to AA by the added tris(2-carboxyethy)phosphine (TCEP).	ascorbate-2-phosphate	128-131	serpin family F member 2	Homo sapiens	99-126
22862802-5	2012	It was found that basic fibroblast growth factor, epidermal growth factor and ascorbic acid 2-phosphate promoted HGF secretion in MSCs.	ascorbate-2-phosphate	78-103	hepatocyte growth factor	Rattus norvegicus	113-116
23081981-0	2012	Role of hepatocyte growth factor in promoting the growth of human corneal endothelial cells stimulated by L-ascorbic acid 2-phosphate.	ascorbate-2-phosphate	106-133	hepatocyte growth factor	Homo sapiens	8-32