PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31543522-3	2019	Therefore, to bring clarity to this relationship we disrupted expression of the endothelial gap junction connexin 43 (Cx43) by exposing confluent human umbilical vein endothelial cells (HUVECs) to a low (0.2 mug/mL) and high (2 mug/mL) concentration of 2,5-dihydroxychalcone (chalcone), a known Cx43 inhibitor.	2',5'-dihydroxychalcone	253-274	gap junction protein alpha 1	Homo sapiens	105-116
31543522-3	2019	Therefore, to bring clarity to this relationship we disrupted expression of the endothelial gap junction connexin 43 (Cx43) by exposing confluent human umbilical vein endothelial cells (HUVECs) to a low (0.2 mug/mL) and high (2 mug/mL) concentration of 2,5-dihydroxychalcone (chalcone), a known Cx43 inhibitor.	2',5'-dihydroxychalcone	253-274	gap junction protein alpha 1	Homo sapiens	118-122
12204542-0	2002	2",5"-Dihydroxychalcone down-regulates endothelial connexin43 gap junctions and affects MAP kinase activation.	2',5'-dihydroxychalcone	0-23	gap junction protein alpha 1	Homo sapiens	51-61
21712085-5	2011	2",5"-DHC treatment induced phosphorylation of the c-Jun N-terminal kinase (JNK) pathway, which was also inhibited by MnTDE-1,3-IP(5+).	2',5'-dihydroxychalcone	0-9	mitogen-activated protein kinase 8	Homo sapiens	51-74
21712085-5	2011	2",5"-DHC treatment induced phosphorylation of the c-Jun N-terminal kinase (JNK) pathway, which was also inhibited by MnTDE-1,3-IP(5+).	2',5'-dihydroxychalcone	0-9	mitogen-activated protein kinase 8	Homo sapiens	76-79
21712085-7	2011	However, whereas 2",5"-DHC triggered the NF-E2-related factor 2 (Nrf2) transcriptional response, cotreatment with MnTDE-1,3-IP(5+) did not decrease 2",5"-DHC-induced Nrf2/ARE activity, showing that this pathway is not dependent on ROS.	2',5'-dihydroxychalcone	17-26	NFE2 like bZIP transcription factor 2	Homo sapiens	65-69
21712085-8	2011	Moreover, pharmacological inhibitors of mitogen-activated protein kinase (MAPK) pathways showed a role for JNK and p38MAPK in mediating the 2",5"-DHC-induced Nrf2 response.	2',5'-dihydroxychalcone	140-149	mitogen-activated protein kinase 8	Homo sapiens	107-110
21712085-8	2011	Moreover, pharmacological inhibitors of mitogen-activated protein kinase (MAPK) pathways showed a role for JNK and p38MAPK in mediating the 2",5"-DHC-induced Nrf2 response.	2',5'-dihydroxychalcone	140-149	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
20826087-3	2010	The hydroxychalcones, 2",5"-dihydroxychalcone (D-601) and 2,2"-dihydroxychalcone (D-501), were found to activate heat shock factor 1 (Hsf1) and exhibited radiation sensitization properties in colon and pancreatic cancer cells.	2',5'-dihydroxychalcone	22-45	heat shock transcription factor 1	Homo sapiens	113-132
20826087-3	2010	The hydroxychalcones, 2",5"-dihydroxychalcone (D-601) and 2,2"-dihydroxychalcone (D-501), were found to activate heat shock factor 1 (Hsf1) and exhibited radiation sensitization properties in colon and pancreatic cancer cells.	2',5'-dihydroxychalcone	22-45	heat shock transcription factor 1	Homo sapiens	134-138
20332504-3	2010	Human epithelial MDA1586, A549, H1975, H460, HN4, and H157 cell lines were exposed to 2",5"-dihydroxychalcone, which induces a GSH efflux response.	2',5'-dihydroxychalcone	86-109	MT-RNR2 like 4 (pseudogene)	Homo sapiens	45-48
20332504-5	2010	ABCG2 was identified as the only gene in the array that closely corresponded with the magnitude of 2",5"-dihydroxychalcone (2",5"-DHC)-induced GSH efflux.	2',5'-dihydroxychalcone	99-122	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-5
20332504-5	2010	ABCG2 was identified as the only gene in the array that closely corresponded with the magnitude of 2",5"-dihydroxychalcone (2",5"-DHC)-induced GSH efflux.	2',5'-dihydroxychalcone	124-133	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-5
20332504-9	2010	In contrast, 2",5"-DHC treatment of ABCG2-expressing yeast increased extracellular GSH levels in a dose-dependent manner with a maximum 3.5-fold increase in GSH after 24 h. In addition, suppression of ABCG2 with short hairpin RNA or ABCG2 overexpression in human epithelial cells decreased or increased extracellular GSH levels, respectively.	2',5'-dihydroxychalcone	13-22	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	36-41
20332504-9	2010	In contrast, 2",5"-DHC treatment of ABCG2-expressing yeast increased extracellular GSH levels in a dose-dependent manner with a maximum 3.5-fold increase in GSH after 24 h. In addition, suppression of ABCG2 with short hairpin RNA or ABCG2 overexpression in human epithelial cells decreased or increased extracellular GSH levels, respectively.	2',5'-dihydroxychalcone	13-22	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	201-206
20332504-9	2010	In contrast, 2",5"-DHC treatment of ABCG2-expressing yeast increased extracellular GSH levels in a dose-dependent manner with a maximum 3.5-fold increase in GSH after 24 h. In addition, suppression of ABCG2 with short hairpin RNA or ABCG2 overexpression in human epithelial cells decreased or increased extracellular GSH levels, respectively.	2',5'-dihydroxychalcone	13-22	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	201-206
12204542-1	2002	We examined the effect of 2",5"-dihydroxychalcone on connexin43 (Cx43) expression and gap-junctional communication in human umbilical vein endothelial cells (HUVEC).	2',5'-dihydroxychalcone	26-49	gap junction protein alpha 1	Homo sapiens	53-63
12204542-1	2002	We examined the effect of 2",5"-dihydroxychalcone on connexin43 (Cx43) expression and gap-junctional communication in human umbilical vein endothelial cells (HUVEC).	2',5'-dihydroxychalcone	26-49	gap junction protein alpha 1	Homo sapiens	65-69
12204542-2	2002	The result showed that expression of Cx43 is rapidly reduced by 2",5"-dihydroxychalcone in a dose-dependent manner, Concomitantly, the communication function, determined by fluorescence recovery after photobleaching (FRAP), is decreased.	2',5'-dihydroxychalcone	64-87	gap junction protein alpha 1	Homo sapiens	37-41
12204542-7	2002	On the other hand, the chalcone"s down-regulating effect on Cx43, while is totally blocked by protease inhibitors leupeptin and N-acetyl-leucyl-norleucinal (ALLN), persists in the presence of PD98059, We concluded that 2",5"-dihydroxychalcone down-regulates Cx43 expression and gap-junctional communication in the HUVEC via enhancement of the proteolysis pathway, and this compound possesses dual effects on MAP kinase activation.	2',5'-dihydroxychalcone	219-242	gap junction protein alpha 1	Homo sapiens	60-64
31633688-2	2019	Therefore, we present here a mechanics-based protocol to probe the influence of gap junction connexin 43 (Cx43) has on endothelial biomechanics by exposing confluent endothelial monolayers to a known Cx43 inhibitor 2,5-dihydroxychalcone (chalcone) and measuring the impact this inhibitor has on tractions and intercellular stresses.	2',5'-dihydroxychalcone	215-236	gap junction protein alpha 1	Homo sapiens	93-104
31633688-2	2019	Therefore, we present here a mechanics-based protocol to probe the influence of gap junction connexin 43 (Cx43) has on endothelial biomechanics by exposing confluent endothelial monolayers to a known Cx43 inhibitor 2,5-dihydroxychalcone (chalcone) and measuring the impact this inhibitor has on tractions and intercellular stresses.	2',5'-dihydroxychalcone	215-236	gap junction protein alpha 1	Homo sapiens	106-110
31633688-2	2019	Therefore, we present here a mechanics-based protocol to probe the influence of gap junction connexin 43 (Cx43) has on endothelial biomechanics by exposing confluent endothelial monolayers to a known Cx43 inhibitor 2,5-dihydroxychalcone (chalcone) and measuring the impact this inhibitor has on tractions and intercellular stresses.	2',5'-dihydroxychalcone	215-236	gap junction protein alpha 1	Homo sapiens	200-204