PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 16363792-1 2005 Cystathionine beta-synthase (CBS) is a pyridoxal-5"-dependent enzyme that catalyzes the condensation of homocysteine and serine to form cystathionine. Cystathionine 136-149 cystathionine beta-synthase Homo sapiens 0-27 16363792-1 2005 Cystathionine beta-synthase (CBS) is a pyridoxal-5"-dependent enzyme that catalyzes the condensation of homocysteine and serine to form cystathionine. Cystathionine 136-149 cystathionine beta-synthase Homo sapiens 29-32 15698597-12 2005 Conversely, L-cystathionine and N-acetyl-L-cysteine inhibited the translocation to membrane of p47(phox) and p67(phox) in a concentration-dependent manner. Cystathionine 12-27 pleckstrin Homo sapiens 99-103 15893507-7 2005 When cystathionine, cystine and S-methylcysteine were used as substrates, pyruvate was produced by TTHA1620. Cystathionine 5-18 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme Thermus thermophilus HB8 99-107 15890026-1 2005 Cystathionine gamma-lyase (CSE) is an enzyme catalyzing cystathionine and cysteine to yield cysteine and hydrogen sulfide (H(2)S), respectively. Cystathionine 56-69 cystathionine gamma-lyase Rattus norvegicus 0-25 15890026-1 2005 Cystathionine gamma-lyase (CSE) is an enzyme catalyzing cystathionine and cysteine to yield cysteine and hydrogen sulfide (H(2)S), respectively. Cystathionine 56-69 cystathionine gamma-lyase Rattus norvegicus 27-30 15890029-1 2005 Cystathionine beta-synthase (CBS) is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and homocysteine to cystathionine and water. Cystathionine 143-156 cystathionine beta-synthase Homo sapiens 0-27 15890029-1 2005 Cystathionine beta-synthase (CBS) is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and homocysteine to cystathionine and water. Cystathionine 143-156 cystathionine beta-synthase Homo sapiens 29-32 15698597-12 2005 Conversely, L-cystathionine and N-acetyl-L-cysteine inhibited the translocation to membrane of p47(phox) and p67(phox) in a concentration-dependent manner. Cystathionine 12-27 pleckstrin Homo sapiens 95-104 15698597-12 2005 Conversely, L-cystathionine and N-acetyl-L-cysteine inhibited the translocation to membrane of p47(phox) and p67(phox) in a concentration-dependent manner. Cystathionine 12-27 CD33 molecule Homo sapiens 109-112 15698597-16 2005 L-cystathionine and N-acetyl-L-cysteine suppressed fMLP- and PMA-induced superoxide generation by the inhibition of translocation to membrane of p47(phox) and p67(phox). Cystathionine 0-15 pleckstrin Homo sapiens 145-154 15698597-16 2005 L-cystathionine and N-acetyl-L-cysteine suppressed fMLP- and PMA-induced superoxide generation by the inhibition of translocation to membrane of p47(phox) and p67(phox). Cystathionine 0-15 CD33 molecule Homo sapiens 159-162 15698597-16 2005 L-cystathionine and N-acetyl-L-cysteine suppressed fMLP- and PMA-induced superoxide generation by the inhibition of translocation to membrane of p47(phox) and p67(phox). Cystathionine 0-15 pleckstrin Homo sapiens 149-153 15196993-1 2004 Cystathionine beta-synthase catalyzes the condensation of serine and homocysteine to give cystathionine in a pyridoxal phosphate (PLP)-dependent reaction. Cystathionine 90-103 cystathionine beta-synthase Homo sapiens 0-27 15520012-4 2004 Here we show that the CBS enzyme can efficiently produce H2S via a beta-replacement reaction in which cysteine is condensed with homocysteine to form cystathionine and H2S. Cystathionine 150-163 cystathionine beta-synthase Homo sapiens 22-25 15642325-2 2004 We examined the presence of the gene for cystathionine-beta-synthase (CBS), the rate limiting enzyme that converts homocysteine to cystathionine in the transsulfuration pathway, in human lens epithelial (HLE) B3 cells using PCR with primers designed based on the sequence of human liver CBS (Forward 5"-CCA CAC TGC CCC GGC AAA AT-3"; Reverse 5"-CTG GCA ATG CCC GTG ATG GT-3"). Cystathionine 41-54 cystathionine beta-synthase Homo sapiens 70-73 15262267-3 2004 Of 35 amino acids quantified, we found significant dysregulation in SSADH(-/-) mice for 11 (GABA, glutamate, glutamine, alanine, aspartate, serine, taurine, cystathionine, methionine, homocarnosine, and arginine) as compared to age-matched littermates both before, and following, the period of generalized convulsive seizures and status epilepticus. Cystathionine 157-170 aldhehyde dehydrogenase family 5, subfamily A1 Mus musculus 68-73 12686104-2 2003 Cystathionine beta-synthase catalyzes a PLP-dependent condensation of serine and homocysteine to cystathionine and is unique in also having a heme cofactor. Cystathionine 97-110 cystathionine beta-synthase Homo sapiens 0-27 15151507-3 2004 Recently, we discovered that cystathioninuria was caused by mutations in the CTH gene encoding cystathionine gamma-lyase, an enzyme that converts cystathionine to cysteine in the trans-sulfuration pathway. Cystathionine 95-108 V-set and immunoglobulin domain containing 2 Homo sapiens 77-80 15105297-2 2004 Cystathionine beta-synthase (CBS) is an enzyme that condenses homocysteine with serine to form cystathionine. Cystathionine 95-108 cystathionine beta-synthase Mus musculus 0-27 15105297-2 2004 Cystathionine beta-synthase (CBS) is an enzyme that condenses homocysteine with serine to form cystathionine. Cystathionine 95-108 cystathionine beta-synthase Mus musculus 29-32 12837693-7 2003 Amino acid analysis confirmed the defect in SAA metabolism: homocystine, cysteine, cystathionine and serine were significantly decreased in frataxin-deficient cell extracts and mitochondria. Cystathionine 83-96 frataxin Homo sapiens 140-148 12686134-1 2003 Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyses a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Cystathionine 173-186 cystathionine beta-synthase Homo sapiens 0-27 12686134-1 2003 Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyses a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Cystathionine 173-186 cystathionine beta-synthase Homo sapiens 29-32 15016471-6 2004 GTK also catalyzes the transamination of cystathionine, lanthionine, and thialysine to the corresponding alpha-keto acids, which cyclize to ketimines. Cystathionine 41-54 kynurenine aminotransferase 1 Homo sapiens 0-3 14670973-1 2004 Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and transsulfuration. Cystathionine 97-110 cystathionine beta-synthase Homo sapiens 0-27 12686104-2 2003 Cystathionine beta-synthase catalyzes a PLP-dependent condensation of serine and homocysteine to cystathionine and is unique in also having a heme cofactor. Cystathionine 97-110 proteolipid protein 1 Homo sapiens 40-43 12574942-8 2003 Also, the availability of a common non-synonymous SNP can allow for testing of association of the CTH gene with biochemical traits affected by trans-sulfuration, such as plasma concentrations of homocysteine or even cystathionine itself, in addition to more downstream clinical phenotypes, such as vascular disease. Cystathionine 216-229 cystathionine gamma-lyase Homo sapiens 98-101 12379655-2 2002 Cystathionine beta-synthase is a tetrameric hemeprotein that catalyzes the pyridoxal 5"-phosphate-dependent condensation of serine and homocysteine to cystathionine. Cystathionine 151-164 cystathionine beta-synthase Homo sapiens 0-27 12631446-2 2003 The latter condenses homocysteine and serine to cystathionine in a reaction catalyzed by cystathionine beta-synthase followed by cleavage of cystathionine to cysteine and alpha-ketoglutarate by gamma-cystathionase. Cystathionine 48-61 cystathionine beta-synthase Homo sapiens 89-116 12631446-2 2003 The latter condenses homocysteine and serine to cystathionine in a reaction catalyzed by cystathionine beta-synthase followed by cleavage of cystathionine to cysteine and alpha-ketoglutarate by gamma-cystathionase. Cystathionine 48-61 cystathionine gamma-lyase Homo sapiens 194-213 12631446-2 2003 The latter condenses homocysteine and serine to cystathionine in a reaction catalyzed by cystathionine beta-synthase followed by cleavage of cystathionine to cysteine and alpha-ketoglutarate by gamma-cystathionase. Cystathionine 89-102 cystathionine gamma-lyase Homo sapiens 194-213 12427542-1 2002 Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine. Cystathionine 96-109 cystathionine beta-synthase Homo sapiens 0-27 12198128-2 2002 Cystathionine beta-synthase (CBS), a key enzyme involved in the transsulfuration pathway, which irreversibly converts homocysteine to cysteine, catalyzes the condensation of serine and homocysteine to cystathionine. Cystathionine 201-214 cystathionine beta synthase Rattus norvegicus 0-27 12198128-2 2002 Cystathionine beta-synthase (CBS), a key enzyme involved in the transsulfuration pathway, which irreversibly converts homocysteine to cysteine, catalyzes the condensation of serine and homocysteine to cystathionine. Cystathionine 201-214 cystathionine beta synthase Rattus norvegicus 29-32 11744062-1 2001 Homocysteine is a key junction metabolite that can be converted to cystathionine in a reaction catalyzed by the heme and pyridoxal phosphate-dependent cystathionine beta-synthase. Cystathionine 67-80 cystathionine beta-synthase Homo sapiens 151-178 11827570-8 2002 Homocysteine was the most efficacious of the tested cystathionine precursors in increasing the GSH content and reducing the cytotoxicity of DEM and diamide in Fa32 and HEp-G2 cells. Cystathionine 52-65 DNL-type zinc finger Homo sapiens 168-171 12115739-1 2002 Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration. Cystathionine 97-110 cystathionine beta-synthase Homo sapiens 0-27 12115739-1 2002 Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration. Cystathionine 97-110 cystathionine beta-synthase Homo sapiens 29-32 12054683-4 2002 In addition to H2S production CBS also catalyzes another metabolic pathway in which cystathionine is produced from the substrate homocysteine. Cystathionine 84-97 cystathionine beta-synthase Homo sapiens 30-33 11562358-1 2001 Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine. Cystathionine 96-109 cystathionine beta-synthase Homo sapiens 0-27 11568918-7 2001 In addition, the child had a five-fold increase in cystathionine level relative to normal children, consistent with over-expression of the cystathionine beta synthase gene present on chromosome 21. Cystathionine 51-64 cystathionine beta-synthase Homo sapiens 139-166 11483494-1 2001 Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Cystathionine 174-187 cystathionine beta-synthase Homo sapiens 0-27 11592449-1 2001 In a pilot study we measured the effect of three different combinations of the vitamins B6, folate and B12 on the serum concentrations of homocysteine, cystathionine and methylmalonic acid in five healthy young men without hyperhomocysteinemia. Cystathionine 152-165 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 103-106 11483494-1 2001 Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Cystathionine 174-187 cystathionine beta-synthase Homo sapiens 29-32 11483494-1 2001 Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Cystathionine 174-187 pyridoxal phosphatase Homo sapiens 111-114 11173483-1 2001 Cystathionine beta-synthase (CBS) is a unique heme enzyme that catalyzes a PLP-dependent condensation of serine and homocysteine to give cystathionine. Cystathionine 137-150 cystathionine beta-synthase Homo sapiens 0-27 11415440-1 2001 Cystathionine beta-synthase (CBS) catalyses the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine. Cystathionine 96-109 cystathionine beta-synthase Homo sapiens 0-27 11415440-1 2001 Cystathionine beta-synthase (CBS) catalyses the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine. Cystathionine 96-109 cystathionine beta-synthase Homo sapiens 29-32 11402193-8 2001 In addition, the binding pocket of Arabidopsis CBL is larger than that of E. coli CBL, explaining the similar binding of L-cystathionine and L-djenkolate in Arabidopsis CBL in contrast to E. coli CBL, where the substrate binding site is optimized for the natural substrate cystathionine. Cystathionine 121-136 cystathionine beta-lyase Arabidopsis thaliana 47-50 11402193-8 2001 In addition, the binding pocket of Arabidopsis CBL is larger than that of E. coli CBL, explaining the similar binding of L-cystathionine and L-djenkolate in Arabidopsis CBL in contrast to E. coli CBL, where the substrate binding site is optimized for the natural substrate cystathionine. Cystathionine 121-136 cystathionine beta-lyase Arabidopsis thaliana 82-85 11402193-8 2001 In addition, the binding pocket of Arabidopsis CBL is larger than that of E. coli CBL, explaining the similar binding of L-cystathionine and L-djenkolate in Arabidopsis CBL in contrast to E. coli CBL, where the substrate binding site is optimized for the natural substrate cystathionine. Cystathionine 121-136 cystathionine beta-lyase Arabidopsis thaliana 82-85 11402193-8 2001 In addition, the binding pocket of Arabidopsis CBL is larger than that of E. coli CBL, explaining the similar binding of L-cystathionine and L-djenkolate in Arabidopsis CBL in contrast to E. coli CBL, where the substrate binding site is optimized for the natural substrate cystathionine. Cystathionine 121-136 cystathionine beta-lyase Arabidopsis thaliana 82-85 11402193-8 2001 In addition, the binding pocket of Arabidopsis CBL is larger than that of E. coli CBL, explaining the similar binding of L-cystathionine and L-djenkolate in Arabidopsis CBL in contrast to E. coli CBL, where the substrate binding site is optimized for the natural substrate cystathionine. Cystathionine 123-136 cystathionine beta-lyase Arabidopsis thaliana 47-50 11402193-8 2001 In addition, the binding pocket of Arabidopsis CBL is larger than that of E. coli CBL, explaining the similar binding of L-cystathionine and L-djenkolate in Arabidopsis CBL in contrast to E. coli CBL, where the substrate binding site is optimized for the natural substrate cystathionine. Cystathionine 123-136 cystathionine beta-lyase Arabidopsis thaliana 82-85 11402193-8 2001 In addition, the binding pocket of Arabidopsis CBL is larger than that of E. coli CBL, explaining the similar binding of L-cystathionine and L-djenkolate in Arabidopsis CBL in contrast to E. coli CBL, where the substrate binding site is optimized for the natural substrate cystathionine. Cystathionine 123-136 cystathionine beta-lyase Arabidopsis thaliana 82-85 11402193-8 2001 In addition, the binding pocket of Arabidopsis CBL is larger than that of E. coli CBL, explaining the similar binding of L-cystathionine and L-djenkolate in Arabidopsis CBL in contrast to E. coli CBL, where the substrate binding site is optimized for the natural substrate cystathionine. Cystathionine 123-136 cystathionine beta-lyase Arabidopsis thaliana 82-85 11173483-1 2001 Cystathionine beta-synthase (CBS) is a unique heme enzyme that catalyzes a PLP-dependent condensation of serine and homocysteine to give cystathionine. Cystathionine 137-150 cystathionine beta-synthase Homo sapiens 29-32 10708546-2 2000 Among the cystathionine metabolites, cystathionine ketimine and N-acetyl-S-(3-oxo-3-carboxy-n-propyl) cysteine (NAc-OCPC) significantly enhanced the N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide generation, but cystathionine, NAc-cystathionine, and cyclothionine did not enhance the superoxide generation. Cystathionine 37-50 formyl peptide receptor 1 Homo sapiens 187-191 10994627-0 2000 Is the increase in serum cystathionine levels in patients with liver cirrhosis a consequence of impaired homocysteine transsulfuration at the level of gamma-cystathionase? Cystathionine 25-38 cystathionine gamma-lyase Homo sapiens 151-170 10708546-2 2000 Among the cystathionine metabolites, cystathionine ketimine and N-acetyl-S-(3-oxo-3-carboxy-n-propyl) cysteine (NAc-OCPC) significantly enhanced the N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide generation, but cystathionine, NAc-cystathionine, and cyclothionine did not enhance the superoxide generation. Cystathionine 10-23 X-linked Kx blood group Homo sapiens 112-115 10708546-2 2000 Among the cystathionine metabolites, cystathionine ketimine and N-acetyl-S-(3-oxo-3-carboxy-n-propyl) cysteine (NAc-OCPC) significantly enhanced the N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide generation, but cystathionine, NAc-cystathionine, and cyclothionine did not enhance the superoxide generation. Cystathionine 37-50 X-linked Kx blood group Homo sapiens 243-246 10052944-1 1999 Cystathionine beta-synthase is an unusual enzyme that requires the cofactors heme and pyridoxal phosphate (PLP) to catalyze the condensation of homocysteine and serine to generate cystathionine. Cystathionine 180-193 cystathionine beta-synthase Homo sapiens 0-27 16232856-6 2000 Both the MET2- and MET17-disrupted mutants could grow in a minimal medium containing homocysteine but not in the same medium containing succinylhomoserine or cystathionine. Cystathionine 158-171 bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 Saccharomyces cerevisiae S288C 19-24 10595588-2 1999 The recombinant cystathionine gamma-synthase catalyses the pyridoxal 5"-phosphate dependent formation of L-cystathionine from L-homoserine phosphate and L-cysteine with apparent Km-values of 7.1+/-3.1 mM and of 0.23+/-0.07 mM, respectively. Cystathionine 105-120 cystathionine gamma-synthase 1, chloroplastic-like Nicotiana tabacum 16-44 10797837-4 1999 It is normally catalyzed to cystathionine by cystathionine beta-synthase a pyridoxal phosphate-dependent enzyme. Cystathionine 28-41 cystathionine beta-synthase Homo sapiens 45-72 10052942-1 1999 Cystathionine beta-synthase (CBS), a pyridoxal 5"-phosphate (PLP) dependent enzyme, catalyzes the condensation of serine and homocysteine to form cystathionine. Cystathionine 146-159 cystathionine beta-synthase Homo sapiens 0-27 10052942-1 1999 Cystathionine beta-synthase (CBS), a pyridoxal 5"-phosphate (PLP) dependent enzyme, catalyzes the condensation of serine and homocysteine to form cystathionine. Cystathionine 146-159 cystathionine beta-synthase Homo sapiens 29-32 10052942-1 1999 Cystathionine beta-synthase (CBS), a pyridoxal 5"-phosphate (PLP) dependent enzyme, catalyzes the condensation of serine and homocysteine to form cystathionine. Cystathionine 146-159 pyridoxal phosphatase Homo sapiens 61-64 9235230-3 1997 It is normally catalysed to cystathionine by cystathionine beta-synthase a pyridoxal phosphate-dependent enzyme. Cystathionine 28-41 cystathionine beta-synthase Homo sapiens 45-72 9675031-1 1998 Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine and serine to cystathionine-an irreversible step in the eukaryotic transsulfuration pathway. Cystathionine 91-104 cystathionine beta-synthase Homo sapiens 0-27 9466825-1 1998 Cystathionine beta-synthase (CBS) catalyzes the irreversible, serine-dependent conversion of homocysteine to cystathionine via a transsulfuration pathway. Cystathionine 109-122 cystathionine beta-synthase Homo sapiens 0-27 9466825-1 1998 Cystathionine beta-synthase (CBS) catalyzes the irreversible, serine-dependent conversion of homocysteine to cystathionine via a transsulfuration pathway. Cystathionine 109-122 cystathionine beta-synthase Homo sapiens 29-32 9389904-6 1997 The inhibition of gamma-cystathionase was reflected in the blood levels of amino acids, because the L-methionine: L-cyst(e)ine ratio was significantly higher in PPG-treated rats than in control rats; blood concentration of cystathionine was also greater. Cystathionine 223-236 cystathionine gamma-lyase Rattus norvegicus 18-37 9488680-5 1998 rMGL1 and rMGL2 were found to have high activity toward methionine (10.4 and 0.67 mumol/min/mg of protein, respectively), homocysteine (370 and 128 mumol/min/mg of protein), cysteine (6.02 and 1.06 mumol/min/mg of protein), and O-acetylserine (3.74 and 1.51 mumol/min/mg of protein), but to be inactive toward cystathionine. Cystathionine 310-323 C-type lectin domain containing 10A Rattus norvegicus 0-5 8304446-7 1994 Insulin infusion significantly decreased the arterial concentration of every amino acid with the exception of cystathionine and significantly increased limb blood flow and glucose uptake. Cystathionine 110-123 LOC105613195 Ovis aries 0-7 8541513-1 1995 Cystathionine beta-lyase, the second enzyme involved in the methionine biosynthetic pathway in plants, catalyses the synthesis of homocysteine from cystathionine. Cystathionine 148-161 cystathionine beta-lyase Arabidopsis thaliana 0-24 8973544-1 1996 Cystathionine beta-lyase is a key enzyme in sulphur metabolism that catalyses the second reaction specific for methionine biosynthesis, the pyridoxal 5"-phosphate-dependent beta-cleavage of cystathionine to produce homocysteine. Cystathionine 190-203 cystathionine beta-lyase Arabidopsis thaliana 0-24 8973544-9 1996 The cystathionine analogue aminoethoxyvinylglycine irreversibly inactivates the recombinant cystathionine beta-lyase. Cystathionine 4-17 cystathionine beta-lyase Arabidopsis thaliana 92-116 7492971-9 1995 These findings indicated that at least one reason of the high content of cystathionine in the 3 weeks rat cerebellum was due to the low level of cystathionine gamma-lyase. Cystathionine 73-86 cystathionine gamma-lyase Rattus norvegicus 145-170 34517051-4 2022 Levels of methionine, S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) and cystathionine were positively correlated with NFE2L2 expression, while homocysteine (HCY) was negatively correlated. Cystathionine 83-96 NFE2 like bZIP transcription factor 2 Homo sapiens 129-135 8335636-13 1993 The protein showed a number of cystathionine-related activities, i.e., cystathionine beta-lyase (EC 4.4.1.8), cystathionine gamma-lyase, and cystathionine gamma-synthase (EC 4.2.99.9) with L-homoserine as substrate. Cystathionine 31-44 cystathionine gamma-synthase Saccharomyces cerevisiae S288C 141-169 1629286-6 1992 Cystathionine beta-synthase activity was measured by the same method by determining cystathionine formed in only 113 ng of wet weight of rat liver. Cystathionine 84-97 cystathionine beta synthase Rattus norvegicus 0-27 8507876-2 1993 Homocysteine can also condense with serine to form cystathionine in a pyridoxal phosphate-dependent reaction catalyzed by cystathionine beta-synthase. Cystathionine 51-64 cystathionine beta-synthase Homo sapiens 122-149 8507876-3 1993 Cystathionine is subsequently cleaved to cysteine and alpha-ketobutyrate by the pyridoxal phosphate-dependent enzyme gamma-cystathionase. Cystathionine 0-13 cystathionine gamma-lyase Homo sapiens 117-136 18278872-1 2008 Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to cystathionine, which represents the committing step in the transsulfuration pathway. Cystathionine 91-104 cystathionine beta-synthase Homo sapiens 0-27 18278872-1 2008 Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to cystathionine, which represents the committing step in the transsulfuration pathway. Cystathionine 91-104 cystathionine beta-synthase Homo sapiens 29-32 6614921-6 1983 The ability of normal tissues to synthesize cystathionine utilizing cystathionine beta-synthase was 1.98 +/- 0.40 mumol/min/g in liver, 0.61 +/- 0.13 in kidney, and 0.18 +/- 0.015 in brain. Cystathionine 44-57 cystathionine beta synthase Rattus norvegicus 68-95 34923141-9 2022 Knockdown of GFPT2 decreased cystathionine and sulfide:quinone oxidoreductase (SQOR) in the transsulfuration pathway that regulates H2S production and mitochondrial homeostasis. Cystathionine 29-42 glutamine-fructose-6-phosphate transaminase 2 Homo sapiens 13-18 33949005-1 2021 Cystathionine beta-synthase (CBS) is a key enzyme of the trans-sulfuration pathway that converts homocysteine to cystathionine. Cystathionine 113-126 cystathionine beta-synthase Mus musculus 0-27 33949005-1 2021 Cystathionine beta-synthase (CBS) is a key enzyme of the trans-sulfuration pathway that converts homocysteine to cystathionine. Cystathionine 113-126 cystathionine beta-synthase Mus musculus 29-32 3793784-2 1986 The second of these enzymes, CT, is apparently present in most cell lines regardless of their tissues of origin, since most cells can grow in vitro in the absence of cystine if they are provided with cystathionine, the intermediate in the pathway. Cystathionine 200-213 cystathionine gamma-lyase Rattus norvegicus 29-31 6885789-0 1983 Similarity of the oxidation products of L-cystathionine by L-amino acid oxidase to those excreted by cystathioninuric patients. Cystathionine 40-55 interleukin 4 induced 1 Homo sapiens 59-79 6885789-1 1983 L-Cystathionine is oxidized by snake venom L-amino acid oxidase at a rate about half that with L-leucine at pH 8.5. Cystathionine 0-15 interleukin 4 induced 1 Homo sapiens 43-63 6885789-2 1983 The appearance of an absorbance at 296 nm and quantitation of the products of oxidation in the presence of catalase indicate formation in the solutions of a seven-membered ketimine ring produced by cyclization of the monoamino monoketo derivative of cystathionine. Cystathionine 250-263 catalase Homo sapiens 107-115 34662447-6 2022 RESULTS: The Pten-KO prostate increased purine nucleotide pools, cystathionine, and both reduced and oxidized glutathione (GSH, GSSG), and gluconate/glucuronate species in addition to cholesteryl sulfate and polyamine precursor ornithine. Cystathionine 65-78 phosphatase and tensin homolog Mus musculus 13-17 34662447-11 2022 CONCLUSIONS: The aqueous metabolomic patterns in Pten-KO prostate and TRAMP NECa shared similarities in the greater pools of cystathionine, GSH/GSSG redox pair, and nucleotides and shunting away from glycolysis-citrate cycle in both models. Cystathionine 125-138 phosphatase and tensin homolog Mus musculus 49-53 34662447-11 2022 CONCLUSIONS: The aqueous metabolomic patterns in Pten-KO prostate and TRAMP NECa shared similarities in the greater pools of cystathionine, GSH/GSSG redox pair, and nucleotides and shunting away from glycolysis-citrate cycle in both models. Cystathionine 125-138 dermatopontin Mus musculus 70-75 33521459-1 2021 Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively. Cystathionine 187-200 cystathionine beta-synthase Homo sapiens 0-27 7155792-8 1982 The FRR of L-cystathionine at an initial concentration of 0.115 mmol X l-1 was only 30% under the same conditions. Cystathionine 11-26 ribosomal protein L4 Rattus norvegicus 71-74 203329-2 1978 Crystal of L-cystathionine are tetragonal, space group P41 with cell constants a = 6.691(1) A, c = 21.998(3) A and Z = 4. Cystathionine 11-26 mitogen-activated protein kinase 1 Homo sapiens 55-58 33719952-2 2021 BACKGROUND: The protein coded by cystathionine beta synthase (CBS) gene act as a catalyzer, converts homocysteine to cystathionine. Cystathionine 33-46 cystathionine beta-synthase Homo sapiens 62-65 33521459-1 2021 Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively. Cystathionine 187-200 cystathionine beta-synthase Homo sapiens 29-32 33262405-1 2020 Cystathionine beta-synthase (CBS) is a eukaryotic enzyme that maintains the cellular homocysteine homeostasis and catalyzes the conversion of homocysteine to L-cystathionine and Hydrogen sulfide, via the trans-sulfuration pathway. Cystathionine 158-173 PALP domain-containing protein Caenorhabditis elegans 0-27 33262405-1 2020 Cystathionine beta-synthase (CBS) is a eukaryotic enzyme that maintains the cellular homocysteine homeostasis and catalyzes the conversion of homocysteine to L-cystathionine and Hydrogen sulfide, via the trans-sulfuration pathway. Cystathionine 158-173 cystathionine beta-synthase Homo sapiens 29-32 32468069-2 2020 Hydrogen sulfide (H2S) has recently been reported to be involved in numerous biological functions, and it has been shown that H2S can enhance the sodium current density, and inhibiting the endogenous production of H2S mediated by cystathionine beta-synthetase (CBS) using O-(carboxymethyl)hydroxylamine hemihydrochloride (AOAA) can significantly reduce the expression of Nav1.7 and thus the sodium current density in rat dorsal root ganglion (DRG) neurons. Cystathionine 230-243 cystathionine beta synthase Rattus norvegicus 261-264 32468069-2 2020 Hydrogen sulfide (H2S) has recently been reported to be involved in numerous biological functions, and it has been shown that H2S can enhance the sodium current density, and inhibiting the endogenous production of H2S mediated by cystathionine beta-synthetase (CBS) using O-(carboxymethyl)hydroxylamine hemihydrochloride (AOAA) can significantly reduce the expression of Nav1.7 and thus the sodium current density in rat dorsal root ganglion (DRG) neurons. Cystathionine 230-243 sodium voltage-gated channel alpha subunit 9 Rattus norvegicus 371-377 31885769-7 2019 Furthermore, L-cystathionine decreased the production of mitochondrial superoxide anion and the expression of Bax and restrained its translocation to mitochondria, increased mitochondrial membrane potential, inhibited mitochondrial permeability transition pore (MPTP) opening, suppressed the leakage of cytochrome c from mitochondria into the cytoplasm, and downregulated activities of caspase-9 and caspase-3. Cystathionine 13-28 BCL2 associated X, apoptosis regulator Homo sapiens 110-113 31864735-18 2020 An interaction of BCS and feeding level was detected for the aforementioned metabolites plus methionine, cystathionine, cysteinesulfinate, and hypotaurine, due to greater overall concentrations in BCS5 cows fed 75% of requirements compared with other groups. Cystathionine 105-118 BCS Bos taurus 18-21 32042803-1 2019 Background: This study aimed to determine the contribution of cystathionine gamma lyase (CSE) to physiological and orthodontic root resorption in mice. Cystathionine 62-75 cystathionase (cystathionine gamma-lyase) Mus musculus 89-92 32937467-0 2020 Cystathione beta-synthase regulates HIF-1alpha stability through persulfidation of PHD2. Cystathionine 0-11 hypoxia inducible factor 1 subunit alpha a Danio rerio 36-46 31638087-4 2020 The enzymes cystathionine beta-synthase, cystathionine gamma-lya-se, and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of H2S. Cystathionine 41-60 cystathionine beta-synthase Homo sapiens 12-39 31885769-7 2019 Furthermore, L-cystathionine decreased the production of mitochondrial superoxide anion and the expression of Bax and restrained its translocation to mitochondria, increased mitochondrial membrane potential, inhibited mitochondrial permeability transition pore (MPTP) opening, suppressed the leakage of cytochrome c from mitochondria into the cytoplasm, and downregulated activities of caspase-9 and caspase-3. Cystathionine 13-28 cytochrome c, somatic Homo sapiens 303-315 31885769-7 2019 Furthermore, L-cystathionine decreased the production of mitochondrial superoxide anion and the expression of Bax and restrained its translocation to mitochondria, increased mitochondrial membrane potential, inhibited mitochondrial permeability transition pore (MPTP) opening, suppressed the leakage of cytochrome c from mitochondria into the cytoplasm, and downregulated activities of caspase-9 and caspase-3. Cystathionine 13-28 caspase 9 Homo sapiens 386-395 31885769-7 2019 Furthermore, L-cystathionine decreased the production of mitochondrial superoxide anion and the expression of Bax and restrained its translocation to mitochondria, increased mitochondrial membrane potential, inhibited mitochondrial permeability transition pore (MPTP) opening, suppressed the leakage of cytochrome c from mitochondria into the cytoplasm, and downregulated activities of caspase-9 and caspase-3. Cystathionine 13-28 caspase 3 Homo sapiens 400-409 31885769-8 2019 However, BTSA1, a Bax agonist, or Bax overexpression successfully abolished the inhibitory effect of L-cystathionine on Hcy-induced MPTP opening, caspase-9 and caspase-3 activation, and HUVEC apoptosis. Cystathionine 101-116 BCL2 associated X, apoptosis regulator Homo sapiens 34-37 31885769-8 2019 However, BTSA1, a Bax agonist, or Bax overexpression successfully abolished the inhibitory effect of L-cystathionine on Hcy-induced MPTP opening, caspase-9 and caspase-3 activation, and HUVEC apoptosis. Cystathionine 101-116 caspase 9 Homo sapiens 146-155 31885769-8 2019 However, BTSA1, a Bax agonist, or Bax overexpression successfully abolished the inhibitory effect of L-cystathionine on Hcy-induced MPTP opening, caspase-9 and caspase-3 activation, and HUVEC apoptosis. Cystathionine 101-116 caspase 3 Homo sapiens 160-169 31611932-2 2019 The cystathionine gamma-lyase/hydrogen sulfide (CSE/H2S) pathway have been associated with several cardiovascular diseases, but the effect of TFR on the Rho-associated protein kinase (ROCK) and CSE/H2S signaling pathways remains unknown. Cystathionine 4-17 cystathionase (cystathionine gamma-lyase) Mus musculus 48-51 31301157-3 2019 Cystathionine-beta-synthase (CBS) is an enzyme that catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine, and in which variations are associated with human hyperhomocysteinemia and homocystinuria. Cystathionine 131-144 cystathionine beta-synthase Homo sapiens 0-27 31582588-5 2019 The expression of CYS3 and CYS4, two transsulfuration pathway genes encoding cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS), were also decreased under mTORC1-Sch9 inhibition. Cystathionine 77-90 cystathionine gamma-lyase CYS3 Saccharomyces cerevisiae S288C 18-22 31582588-5 2019 The expression of CYS3 and CYS4, two transsulfuration pathway genes encoding cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS), were also decreased under mTORC1-Sch9 inhibition. Cystathionine 77-90 cystathionine beta-synthase CYS4 Saccharomyces cerevisiae S288C 27-31 31582588-5 2019 The expression of CYS3 and CYS4, two transsulfuration pathway genes encoding cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS), were also decreased under mTORC1-Sch9 inhibition. Cystathionine 77-90 CREB regulated transcription coactivator 1 Mus musculus 174-180 31582588-5 2019 The expression of CYS3 and CYS4, two transsulfuration pathway genes encoding cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS), were also decreased under mTORC1-Sch9 inhibition. Cystathionine 77-90 serine/threonine protein kinase SCH9 Saccharomyces cerevisiae S288C 181-185 31582588-5 2019 The expression of CYS3 and CYS4, two transsulfuration pathway genes encoding cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS), were also decreased under mTORC1-Sch9 inhibition. Cystathionine 113-126 cystathionine gamma-lyase CYS3 Saccharomyces cerevisiae S288C 18-22 31582588-5 2019 The expression of CYS3 and CYS4, two transsulfuration pathway genes encoding cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS), were also decreased under mTORC1-Sch9 inhibition. Cystathionine 113-126 cystathionine beta-synthase CYS4 Saccharomyces cerevisiae S288C 27-31 31582588-5 2019 The expression of CYS3 and CYS4, two transsulfuration pathway genes encoding cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS), were also decreased under mTORC1-Sch9 inhibition. Cystathionine 113-126 cystathionine beta-synthase Homo sapiens 142-145 31582588-5 2019 The expression of CYS3 and CYS4, two transsulfuration pathway genes encoding cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS), were also decreased under mTORC1-Sch9 inhibition. Cystathionine 113-126 CREB regulated transcription coactivator 1 Mus musculus 174-180 31582588-5 2019 The expression of CYS3 and CYS4, two transsulfuration pathway genes encoding cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS), were also decreased under mTORC1-Sch9 inhibition. Cystathionine 113-126 serine/threonine protein kinase SCH9 Saccharomyces cerevisiae S288C 181-185 31301157-3 2019 Cystathionine-beta-synthase (CBS) is an enzyme that catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine, and in which variations are associated with human hyperhomocysteinemia and homocystinuria. Cystathionine 131-144 cystathionine beta-synthase Homo sapiens 29-32 31421954-6 2019 Concentration of cystathionine, another substrate of xCT, in the thymus and spleen was measured by LC-MS/MS. Cystathionine 17-30 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 Mus musculus 53-56 31160338-6 2019 We observed that CPC inhibited the gamma-elimination reaction of cystathionine and H2S synthesis from cysteine by human CSE with Ki values of 50 +- 3 and 180 +- 15 mum, respectively. Cystathionine 65-78 cystathionine gamma-lyase Homo sapiens 120-123 30726924-7 2019 Selective accumulation of cystathionine was observed in codeleted gliomas in vivo, in brain tissue samples, as well as in cells harboring heterozygous deletions for serine- and cystathionine-pathway genes located on 1p: phosphoglycerate dehydrogenase (PHGDH) and cystathionine gamma-lyase (CTH). Cystathionine 26-39 phosphoglycerate dehydrogenase Homo sapiens 252-257 30726924-7 2019 Selective accumulation of cystathionine was observed in codeleted gliomas in vivo, in brain tissue samples, as well as in cells harboring heterozygous deletions for serine- and cystathionine-pathway genes located on 1p: phosphoglycerate dehydrogenase (PHGDH) and cystathionine gamma-lyase (CTH). Cystathionine 26-39 cystathionine gamma-lyase Homo sapiens 263-288 30726924-7 2019 Selective accumulation of cystathionine was observed in codeleted gliomas in vivo, in brain tissue samples, as well as in cells harboring heterozygous deletions for serine- and cystathionine-pathway genes located on 1p: phosphoglycerate dehydrogenase (PHGDH) and cystathionine gamma-lyase (CTH). Cystathionine 26-39 cystathionine gamma-lyase Homo sapiens 290-293 30646578-4 2019 A common mutation (1364T/T) of the cystathionine-gamma-lyase (CTH) gene affects the enzyme that converts cystathionine to cysteine in the transsulfuration pathway causing plasma elevation of total homocysteine (tHcy) or hyperhomocysteinemia-a strong and independent risk factor for cognitive loss and AD. Cystathionine 35-48 cystathionine gamma-lyase Homo sapiens 62-65 31166132-2 2019 We found that reactive sulfur species (RSS), such as cysteine persulfides produced by cystathionine [Formula: see text] (CSE), capture environmental electrophiles through formation of sulfur adducts. Cystathionine 86-99 cystathionase (cystathionine gamma-lyase) Mus musculus 121-124 29970364-11 2019 Finally, in mice and humans, plasma levels of the CSE substrate l-cystathionine negatively correlated with vascular reactivity and H2S levels, indicating its potential use as a biomarker for vascular disease. Cystathionine 64-79 cystathionase (cystathionine gamma-lyase) Mus musculus 50-53 29275181-2 2018 CBS catalyzes the pyridoxal-5"-phosphate-dependent condensation of serine and homocysteine to form cystathionine, which is subsequently converted into cysteine. Cystathionine 99-112 cystathionine beta-synthase Apis mellifera 0-3 30380942-3 2018 Cystathionine beta-synthase (CBS) plays an important role in Hcy homeostasis catalyzing the irreversible degradation of Hcy to cystathionine, protecting the endothelium from injury caused by hypoxia. Cystathionine 127-140 cystathionine beta-synthase Homo sapiens 0-27 30380942-3 2018 Cystathionine beta-synthase (CBS) plays an important role in Hcy homeostasis catalyzing the irreversible degradation of Hcy to cystathionine, protecting the endothelium from injury caused by hypoxia. Cystathionine 127-140 cystathionine beta-synthase Homo sapiens 29-32 30396922-1 2018 BACKGROUND: Cystathione beta-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway. Cystathionine 128-139 cystathionine beta-synthase Homo sapiens 12-37 30396922-1 2018 BACKGROUND: Cystathione beta-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway. Cystathionine 128-139 cystathionine beta-synthase Homo sapiens 39-42 29803556-1 2018 Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine. Cystathionine 180-193 cystathionine beta-synthase Mus musculus 0-27 29803556-1 2018 Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine. Cystathionine 180-193 cystathionine beta-synthase Mus musculus 29-32 28821635-1 2017 Classical homocystinuria (HCU) is an inborn error of sulfur amino acid metabolism caused by deficient activity of cystathionine beta-synthase (CBS), resulting in an accumulation of homocysteine and a concomitant decrease of cystathionine and cysteine in blood and tissues. Cystathionine 114-127 cystathionine beta-synthase Mus musculus 143-146 29865064-6 2018 Notably, the effects of severe MTHFR deficiency in young mice are recapitulated by prolonged dietary folate deficiency in old mice, which leads to regional brain accumulation of cystathionine due to impaired methylation of homocysteine. Cystathionine 178-191 methylenetetrahydrofolate reductase Mus musculus 31-36 29329322-9 2018 MEASUREMENTS AND MAIN RESULTS: Loss of Mthfr alters single carbon metabolite levels in the lung and serum including elevated homocysteine and cystathionine and reduced methionine. Cystathionine 142-155 methylenetetrahydrofolate reductase Mus musculus 39-44 28675039-1 2017 Cystathionine gamma-synthase (MetB) condenses O-acetyl-l-homoserine (OAHS) or O-succinyl-l-homoserine (OSHS) with cysteine to produce cystathionine. Cystathionine 134-147 cystathionine gamma-synthase 1, chloroplastic-like Nicotiana tabacum 30-34 27664576-9 2016 The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs. Cystathionine 32-47 cystathionine gamma-lyase Homo sapiens 19-22 28232079-8 2017 The action of gamma-cystathionase is dependent upon converting cystathionine to cysteine, a precursor of the major cellular antioxidant, glutathione. Cystathionine 63-76 cystathionase (cystathionine gamma-lyase) Mus musculus 14-33 28291844-5 2017 The RP-HPLC method was used to determine the concentration of cystathionine and alpha-ketobutyrate, products of the CBS- and CTH-catalyzed reactions. Cystathionine 62-75 cystathionine beta-synthase Homo sapiens 116-119 27761974-0 2016 Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability. Cystathionine 45-58 insulin Homo sapiens 65-72 27761974-6 2016 The intra-A-chain cystathionine insulin analogue was obtained in good overall yield, chemically characterized and demonstrated to possess native binding affinity for the insulin receptor isoform B. Cystathionine 18-31 insulin Homo sapiens 32-39 27761974-6 2016 The intra-A-chain cystathionine insulin analogue was obtained in good overall yield, chemically characterized and demonstrated to possess native binding affinity for the insulin receptor isoform B. Cystathionine 18-31 insulin Homo sapiens 170-177 27778219-1 2017 Cystathionine beta-synthase (CBS) deficiency is a rare inherited disorder in the methionine catabolic pathway, in which the impaired synthesis of cystathionine leads to accumulation of homocysteine. Cystathionine 146-159 cystathionine beta-synthase Homo sapiens 0-27 28275971-1 2017 Extreme hyperhomocysteinemia with low cystathionine and cysteine is virtually diagnostic of cystathionine beta-synthase (CBS) deficiency since remethylation defects and hypermethioninemia due to other inborn errors cause elevated serum cystathionine. Cystathionine 38-51 cystathionine beta-synthase Homo sapiens 92-119 28275971-1 2017 Extreme hyperhomocysteinemia with low cystathionine and cysteine is virtually diagnostic of cystathionine beta-synthase (CBS) deficiency since remethylation defects and hypermethioninemia due to other inborn errors cause elevated serum cystathionine. Cystathionine 38-51 cystathionine beta-synthase Homo sapiens 121-124 28275971-1 2017 Extreme hyperhomocysteinemia with low cystathionine and cysteine is virtually diagnostic of cystathionine beta-synthase (CBS) deficiency since remethylation defects and hypermethioninemia due to other inborn errors cause elevated serum cystathionine. Cystathionine 92-105 cystathionine beta-synthase Homo sapiens 121-124 27664576-9 2016 The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs. Cystathionine 32-47 matrix metallopeptidase 1 Homo sapiens 139-143 27664576-9 2016 The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs. Cystathionine 32-47 prostaglandin-endoperoxide synthase 2 Homo sapiens 145-150 27664576-9 2016 The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs. Cystathionine 32-47 C-X-C motif chemokine ligand 8 Homo sapiens 156-161 27664576-9 2016 The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs. Cystathionine 32-47 cystathionine gamma-lyase Homo sapiens 179-182 27664576-9 2016 The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs. Cystathionine 32-47 cystathionine beta-synthase Homo sapiens 187-190 27311614-2 2016 The accumulation of CTH, specifically in HBC, was attributed to the overexpression of cystathionine beta synthase (CBS), its synthesizing enzyme, and the undetectable levels of its downstream metabolizing enzyme, cystathionine gamma lyase (CGL). Cystathionine 20-23 cystathionine beta-synthase Homo sapiens 86-113 30462393-8 2016 The substrates of BHMT and CTH, such as betaine, choline and cystathionine, were decreased in SKO liver while their products including hydrogen sulfide and cysteine were increased. Cystathionine 61-74 betaine-homocysteine methyltransferase Mus musculus 18-22 27311614-2 2016 The accumulation of CTH, specifically in HBC, was attributed to the overexpression of cystathionine beta synthase (CBS), its synthesizing enzyme, and the undetectable levels of its downstream metabolizing enzyme, cystathionine gamma lyase (CGL). Cystathionine 20-23 cystathionine beta-synthase Homo sapiens 115-118 27311614-2 2016 The accumulation of CTH, specifically in HBC, was attributed to the overexpression of cystathionine beta synthase (CBS), its synthesizing enzyme, and the undetectable levels of its downstream metabolizing enzyme, cystathionine gamma lyase (CGL). Cystathionine 20-23 cystathionine gamma-lyase Homo sapiens 213-238 27311614-2 2016 The accumulation of CTH, specifically in HBC, was attributed to the overexpression of cystathionine beta synthase (CBS), its synthesizing enzyme, and the undetectable levels of its downstream metabolizing enzyme, cystathionine gamma lyase (CGL). Cystathionine 20-23 cystathionine gamma-lyase Homo sapiens 240-243 27183385-2 2016 CBS condenses homocysteine and serine to cystathionine that is then converted to cysteine. Cystathionine 41-54 cystathionine beta-synthase Mus musculus 0-3 26791043-1 2016 Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine. Cystathionine 61-74 cystathionine beta-synthase Homo sapiens 90-93 26791043-1 2016 Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine. Cystathionine 61-74 cystathionine gamma-lyase Homo sapiens 120-123 26791043-7 2016 In the remethylation defects the accumulation of homocysteine and the increased flux of metabolites through the transsulfuration pathway resulted in elevation of cystathionine and homolanthionine (857% and 400% of median control values, respectively) indicating a possibility of an increased biosynthesis of H2S by both CBS and CTH. Cystathionine 162-175 cystathionine beta-synthase Homo sapiens 320-323 26791043-7 2016 In the remethylation defects the accumulation of homocysteine and the increased flux of metabolites through the transsulfuration pathway resulted in elevation of cystathionine and homolanthionine (857% and 400% of median control values, respectively) indicating a possibility of an increased biosynthesis of H2S by both CBS and CTH. Cystathionine 162-175 cystathionine gamma-lyase Homo sapiens 328-331 27365395-3 2016 We demonstrate that a kinetically controlled heme-dependent metabolite switch in CBS regulates these competing reactions where by cystathionine, the product of CBS, inhibits H2S synthesis by the second enzyme, CSE. Cystathionine 130-143 cystathionine beta-synthase Homo sapiens 81-84 27365395-3 2016 We demonstrate that a kinetically controlled heme-dependent metabolite switch in CBS regulates these competing reactions where by cystathionine, the product of CBS, inhibits H2S synthesis by the second enzyme, CSE. Cystathionine 130-143 cystathionine beta-synthase Homo sapiens 160-163 27365395-3 2016 We demonstrate that a kinetically controlled heme-dependent metabolite switch in CBS regulates these competing reactions where by cystathionine, the product of CBS, inhibits H2S synthesis by the second enzyme, CSE. Cystathionine 130-143 cystathionine gamma-lyase Homo sapiens 210-213 27365395-4 2016 Under endoplasmic reticulum stress conditions, induction of CSE and up-regulation of the CBS inhibitor, CO, a product of heme oxygenase-1, flip the operating preference of CSE from cystathionine to cysteine, transiently stimulating H2S production. Cystathionine 181-194 cystathionine beta-synthase Homo sapiens 89-92 27365395-4 2016 Under endoplasmic reticulum stress conditions, induction of CSE and up-regulation of the CBS inhibitor, CO, a product of heme oxygenase-1, flip the operating preference of CSE from cystathionine to cysteine, transiently stimulating H2S production. Cystathionine 181-194 heme oxygenase 1 Homo sapiens 121-137 27365395-4 2016 Under endoplasmic reticulum stress conditions, induction of CSE and up-regulation of the CBS inhibitor, CO, a product of heme oxygenase-1, flip the operating preference of CSE from cystathionine to cysteine, transiently stimulating H2S production. Cystathionine 181-194 cystathionine gamma-lyase Homo sapiens 172-175 27365395-6 2016 This metabolite switch from cystathionine to cysteine and/or homocysteine renders H2S synthesis by CSE responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO. Used acutely, it regulates H2S synthesis; used chronically, it might contribute to disease pathology. Cystathionine 28-41 cystathionine gamma-lyase Homo sapiens 99-102 27365395-6 2016 This metabolite switch from cystathionine to cysteine and/or homocysteine renders H2S synthesis by CSE responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO. Used acutely, it regulates H2S synthesis; used chronically, it might contribute to disease pathology. Cystathionine 28-41 cystathionine beta-synthase Homo sapiens 141-144 26765812-4 2016 Thus, cellular and plasma cystathionine concentrations increase in vitamin B6 deficiency mainly due to the bottleneck caused by reduced CSE activity. Cystathionine 26-39 cystathionine gamma-lyase Homo sapiens 136-139 26825869-9 2016 Serum levels of cystathionine increased significantly compared with baseline after FA/B12 administration, but then decreased, fluctuating cyclically during pemetrexed therapy. Cystathionine 16-29 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 86-89 26666246-7 2016 Furthermore, glutamate and cystathionine, both substrates of PLP-dependent enzymes were increased in HD. Cystathionine 27-40 pyridoxal phosphatase Homo sapiens 61-64 26955774-3 2016 Cystathionine-beta-synthase (CBS) is a key-enzyme in the pathway, converting homocysteine into cysteine via cystathionine. Cystathionine 108-121 cystathionine beta-synthase Homo sapiens 0-27 26867575-1 2016 Cystathionine beta-synthase (CBS) is a pyridoxal phosphate-dependent enzyme that catalyzes the condensation of homocysteine with serine or with cysteine to form cystathionine and either water or hydrogen sulfide, respectively. Cystathionine 161-174 cystathionine beta-synthase Homo sapiens 0-27 26184909-6 2016 Knockdown of CARS led to the accumulation of cystathionine, a metabolite on the transsulfuration pathway, and upregulated genes associated with serine biosynthesis and transsulfuration. Cystathionine 45-58 cysteinyl-tRNA synthetase 1 Homo sapiens 13-17 27506718-2 2016 The method exploits cystathionine gamma-lyase as an ancillary enzyme capable of transforming cystathionine, produced by cystathionine beta-synthase, into cysteine. Cystathionine 20-33 cystathionine beta-synthase Bos taurus 120-147 26955774-3 2016 Cystathionine-beta-synthase (CBS) is a key-enzyme in the pathway, converting homocysteine into cysteine via cystathionine. Cystathionine 108-121 cystathionine beta-synthase Homo sapiens 29-32 26051168-1 2015 Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH). Cystathionine 184-197 cystathionine beta-synthase Homo sapiens 0-27 26435880-1 2015 BACKGROUND: Recently a profound depletion of cystathionine gamma-lyase (CSE), the principal enzyme involved in the generation of cysteine from cystathionine, was shown in Huntington disease (HD) patients and several transgenic HD mouse models. Cystathionine 45-58 cystathionine gamma-lyase Homo sapiens 72-75 26051168-1 2015 Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH). Cystathionine 184-197 cystathionine beta-synthase Homo sapiens 29-32 26051168-1 2015 Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH). Cystathionine 199-202 cystathionine beta-synthase Homo sapiens 0-27 26051168-1 2015 Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH). Cystathionine 199-202 cystathionine beta-synthase Homo sapiens 29-32 26051168-7 2015 Silencing of CBS in HBC cells caused a significant decrease in the levels of H2S and CTH but did not affect the growth of these cells per se, in in vitro cultures. Cystathionine 85-88 cystathionine beta-synthase Homo sapiens 13-16 25772816-8 2015 In the presence of PPG, intracellular and medium cystathionine levels for both wild-type and Cdo1 (-/-) cells were increased. Cystathionine 49-62 cysteine dioxygenase 1, cytosolic Mus musculus 93-97 25871637-4 2015 Purified Irc7p also utilized l-cystine and some other cysteine conjugates, but not l-cystathionine or l-methionine, as substrates. Cystathionine 83-98 cysteine-S-conjugate beta-lyase IRC7 Saccharomyces cerevisiae S288C 9-14 26020416-0 2015 L-cystathionine inhibits oxidized low density lipoprotein-induced THP-1-derived macrophage inflammatory cytokine monocyte chemoattractant protein-1 generation via the NF-kappaB pathway. Cystathionine 0-15 GLI family zinc finger 2 Homo sapiens 66-71 26020416-0 2015 L-cystathionine inhibits oxidized low density lipoprotein-induced THP-1-derived macrophage inflammatory cytokine monocyte chemoattractant protein-1 generation via the NF-kappaB pathway. Cystathionine 0-15 C-C motif chemokine ligand 2 Homo sapiens 113-147 26020416-1 2015 This study aimed to explore whether and how L-cystathionine had any regulatory effect on the inflammatory response in THP-1-derived macrophages cultured in vitro under oxidized low-density lipoprotein (ox-LDL) stimulation. Cystathionine 44-59 GLI family zinc finger 2 Homo sapiens 118-123 26020416-5 2015 Compared with the ox-LDL group, 0.3 mmol/L and 1.0 mmol/L L-cystathionine significantly inhibited the expression of THP-1-derived macrophage MCP-1. Cystathionine 58-73 GLI family zinc finger 2 Homo sapiens 116-121 26020416-5 2015 Compared with the ox-LDL group, 0.3 mmol/L and 1.0 mmol/L L-cystathionine significantly inhibited the expression of THP-1-derived macrophage MCP-1. Cystathionine 58-73 C-C motif chemokine ligand 2 Homo sapiens 141-146 26020416-6 2015 Mechanistically, 0.3 mmol/L and 1.0 mmol/L L-cystathionine suppressed phosphorylation and nuclear translocation of the NF-kappaB p65 protein, as well as the DNA binding activity and DNA binding level of NF-kappaB with the MCP-1 promoter, which resulted in a reduced THP-1-derived macrophage MCP-1 generation. Cystathionine 43-58 C-C motif chemokine ligand 2 Homo sapiens 222-227 26020416-6 2015 Mechanistically, 0.3 mmol/L and 1.0 mmol/L L-cystathionine suppressed phosphorylation and nuclear translocation of the NF-kappaB p65 protein, as well as the DNA binding activity and DNA binding level of NF-kappaB with the MCP-1 promoter, which resulted in a reduced THP-1-derived macrophage MCP-1 generation. Cystathionine 43-58 GLI family zinc finger 2 Homo sapiens 266-271 26020416-6 2015 Mechanistically, 0.3 mmol/L and 1.0 mmol/L L-cystathionine suppressed phosphorylation and nuclear translocation of the NF-kappaB p65 protein, as well as the DNA binding activity and DNA binding level of NF-kappaB with the MCP-1 promoter, which resulted in a reduced THP-1-derived macrophage MCP-1 generation. Cystathionine 43-58 C-C motif chemokine ligand 2 Homo sapiens 291-296 26020416-7 2015 This study suggests that L-cystathionine could inhibit the expression of MCP-1 in THP-1-derived macrophages induced by ox-LDL via inhibition of NF-kappaB p65 phosphorylation, nuclear translocation, and binding of the MCP-1 promoter sequence after entry into the nucleus. Cystathionine 25-40 C-C motif chemokine ligand 2 Homo sapiens 73-78 26020416-7 2015 This study suggests that L-cystathionine could inhibit the expression of MCP-1 in THP-1-derived macrophages induced by ox-LDL via inhibition of NF-kappaB p65 phosphorylation, nuclear translocation, and binding of the MCP-1 promoter sequence after entry into the nucleus. Cystathionine 25-40 GLI family zinc finger 2 Homo sapiens 82-87 26020416-7 2015 This study suggests that L-cystathionine could inhibit the expression of MCP-1 in THP-1-derived macrophages induced by ox-LDL via inhibition of NF-kappaB p65 phosphorylation, nuclear translocation, and binding of the MCP-1 promoter sequence after entry into the nucleus. Cystathionine 25-40 C-C motif chemokine ligand 2 Homo sapiens 217-222 23981774-1 2013 Cystathionine beta-synthase (CBS) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine. Cystathionine 157-170 cystathionine beta-synthase Homo sapiens 0-27 25713140-5 2015 Although most of the analyzed metabolites did not show significant alterations between xCT-deficient and wild-type mice, cystathionine emerged as being absent specifically in the thymus and spleen of xCT-deficient mice. Cystathionine 121-134 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 Mus musculus 200-203 24598918-1 2014 Cystathionine beta-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water. Cystathionine 109-122 cystathionine beta-synthase Homo sapiens 0-27 24598918-1 2014 Cystathionine beta-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water. Cystathionine 109-122 cystathionine beta-synthase Homo sapiens 29-32 25624861-1 2014 INTRODUCTION: The cystathionine beta synthase (CBS) gene plays an important role in homocysteine metabolism because it catalyzes the first step of the transsulfuration pathway, during which homocysteine is converted to cystathionine. Cystathionine 18-31 cystathionine beta-synthase Homo sapiens 47-50 25044645-1 2014 Cystathionine beta-synthase (CBS) catalyzes the formation of cystathionine from homocysteine and serine. Cystathionine 61-74 cystathionine beta-synthase Homo sapiens 0-27 25044645-1 2014 Cystathionine beta-synthase (CBS) catalyzes the formation of cystathionine from homocysteine and serine. Cystathionine 61-74 cystathionine beta-synthase Homo sapiens 29-32 24994751-1 2014 UNLABELLED: Cystathionine beta-synthase (CBS) catalyzes metabolic reactions that convert homocysteine to cystathionine. Cystathionine 105-118 cystathionine beta-synthase Homo sapiens 12-39 24994751-1 2014 UNLABELLED: Cystathionine beta-synthase (CBS) catalyzes metabolic reactions that convert homocysteine to cystathionine. Cystathionine 105-118 cystathionine beta-synthase Homo sapiens 41-44 23981774-1 2013 Cystathionine beta-synthase (CBS) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine. Cystathionine 157-170 cystathionine beta-synthase Homo sapiens 29-32 23981774-1 2013 Cystathionine beta-synthase (CBS) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine. Cystathionine 157-170 pyridoxal phosphatase Homo sapiens 63-66 23790103-1 2013 Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively. Cystathionine 109-122 cystathionine beta-synthase Homo sapiens 0-27 23697717-8 2013 Fasting insulin was related with 3-methylhistidine, Asparagine, Alanine, gamma-aminobutyric acid and Cystathionine. Cystathionine 101-114 insulin Homo sapiens 8-15 23350603-3 2013 CDO(-/-) mice had elevated urinary excretion of thiosulfate, high tissue and serum cystathionine and lanthionine levels, and evidence of inhibition and destabilization of cytochrome c oxidase, which is consistent with excess production of H2S/HS(-). Cystathionine 83-96 cysteine dioxygenase 1, cytosolic Mus musculus 0-3 23350603-4 2013 Accumulation of cystathionine and lanthionine appeared to result from cystathionine beta-synthase (CBS)-mediated cysteine desulfhydration. Cystathionine 16-29 cystathionine beta-synthase Mus musculus 70-97 24043838-2 2013 CBS condenses serine and homocysteine to cystathionine with the help of three cofactors, heme, pyridoxal-5"-phosphate, and S-adenosyl-l-methionine. Cystathionine 41-54 cystathionine beta-synthase Homo sapiens 0-3 23315129-1 2013 Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration. Cystathionine 97-110 cystathionine beta-synthase Mus musculus 0-27 23315129-1 2013 Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration. Cystathionine 97-110 cystathionine beta-synthase Mus musculus 29-32 23790103-1 2013 Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively. Cystathionine 109-122 cystathionine beta-synthase Homo sapiens 29-32 23124209-1 2012 Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively. Cystathionine 6-19 cystathionine beta-synthase Homo sapiens 35-38 23470016-1 2013 UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH). Cystathionine 146-159 cystathionine beta-synthase Mus musculus 30-57 23470016-1 2013 UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH). Cystathionine 146-159 cystathionine beta-synthase Mus musculus 59-62 23190757-8 2013 Mthfd1(gt/+) mice also had higher plasma concentrations of homocysteine (P = 0.0016) and cysteine (P < 0.001) as well as lower plasma concentrations of methionine (P = 0.0003) and cystathionine (P = 0.011). Cystathionine 183-196 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase Mus musculus 0-6 23124209-6 2012 In the reverse direction, CBS reacted with cystathionine, forming the aminoacrylate intermediate with k(obs) = 0.38 +- 0.01 mM(-1) s(-1). Cystathionine 43-56 cystathionine beta-synthase Homo sapiens 26-29 23143240-2 2012 CBS catalyzes the beta-replacement reaction of homocysteine (Hcy) with serine to yield cystathionine. Cystathionine 87-100 cystathionine beta-synthase Homo sapiens 0-3 23143241-1 2012 Cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent enzyme that catalyzes the first step of the transsulfuration pathway, namely the condensation of serine with homocysteine to form cystathionine. Cystathionine 202-215 cystathionine beta-synthase Apis mellifera 0-27 23143241-1 2012 Cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent enzyme that catalyzes the first step of the transsulfuration pathway, namely the condensation of serine with homocysteine to form cystathionine. Cystathionine 202-215 cystathionine beta-synthase Apis mellifera 29-32 22333527-1 2012 Cystathionine beta-synthase (CBS), a heme-containing pyridoxal-5-phosphate (PLP)-dependent enzyme, catalyzes the condensation of serine and homocysteine to yield cystathionine. Cystathionine 162-175 cystathionine beta-synthase Homo sapiens 0-27 22738154-1 2012 Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function. Cystathionine 176-189 cystathionine beta-synthase Homo sapiens 0-27 22738154-1 2012 Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function. Cystathionine 176-189 cystathionine beta-synthase Homo sapiens 29-32 22738154-1 2012 Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function. Cystathionine 176-189 cystathionine beta-synthase Homo sapiens 211-214 22854956-2 2012 In mammals, cystathionine is formed as an intermediate of the transsulfuration pathway by the condensation of serine and homocysteine (Hcy) in a reaction catalyzed by cystathionine beta-synthase (CBS). Cystathionine 12-25 cystathionine beta-synthase Mus musculus 167-194 22854956-2 2012 In mammals, cystathionine is formed as an intermediate of the transsulfuration pathway by the condensation of serine and homocysteine (Hcy) in a reaction catalyzed by cystathionine beta-synthase (CBS). Cystathionine 12-25 cystathionine beta-synthase Mus musculus 196-199 22854956-3 2012 Cystathionine is subsequently converted to cysteine plus ammonia and alpha-ketobutyrate by the action of cystathionine gamma-lyase (CGL). Cystathionine 0-13 cystathionase (cystathionine gamma-lyase) Mus musculus 105-130 22854956-3 2012 Cystathionine is subsequently converted to cysteine plus ammonia and alpha-ketobutyrate by the action of cystathionine gamma-lyase (CGL). Cystathionine 0-13 cystathionase (cystathionine gamma-lyase) Mus musculus 132-135 22137257-9 2012 This low CGL reduced cysteine and taurine concentrations in IUGR pigs and led to an accumulation of hepatic cystathionine, with lower homocysteine concentrations. Cystathionine 108-121 cystathionine gamma-lyase Sus scrofa 9-12 22333527-1 2012 Cystathionine beta-synthase (CBS), a heme-containing pyridoxal-5-phosphate (PLP)-dependent enzyme, catalyzes the condensation of serine and homocysteine to yield cystathionine. Cystathionine 162-175 cystathionine beta-synthase Homo sapiens 29-32 22333527-1 2012 Cystathionine beta-synthase (CBS), a heme-containing pyridoxal-5-phosphate (PLP)-dependent enzyme, catalyzes the condensation of serine and homocysteine to yield cystathionine. Cystathionine 162-175 pyridoxal phosphatase Homo sapiens 76-79 24278674-1 2012 Hydrogen sulfide (H2S) is a well-known toxic gas that is synthesized in the human body from the amino acids cystathionine, homocysteine, and cysteine by the action of at least two distinct enzymes: cystathionine-gamma-lyase and cystathionine-beta-synthase. Cystathionine 108-121 cystathionine gamma-lyase Homo sapiens 198-223 22093698-6 2012 Recombinant human GTK (rhGTK) has a relatively open catalytic active site, and we report here that this enzyme, like the rat and bovine enzymes, can also utilize sulfur-containing l-amino acids, including l-methionine, l-cystine, and l-cystathionine as substrates. Cystathionine 234-249 kynurenine aminotransferase 1 Homo sapiens 18-21 20638879-1 2010 Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase. Cystathionine 97-110 cystathionine beta-synthase Mus musculus 0-27 21898591-4 2011 CBS converts HCY to cystathionine, thereby committing it to cysteine synthesis. Cystathionine 20-33 cystathionine beta-synthase Mus musculus 0-3 21480614-1 2011 Human cystathionine beta-synthase (hCBS), a key enzyme in the trans-sulfuration pathway, catalyzes the condensation of serine with homocysteine to produce cystathionine. Cystathionine 6-19 cystathionine beta-synthase Homo sapiens 35-39 21141970-1 2011 Cystathionine beta-synthase (CBS) catalyzes the first step in the transsulfuration pathway in mammals, i.e., the condensation of serine and homocysteine to produce cystathionine and water. Cystathionine 164-177 cystathionine beta-synthase Homo sapiens 0-27 21141970-1 2011 Cystathionine beta-synthase (CBS) catalyzes the first step in the transsulfuration pathway in mammals, i.e., the condensation of serine and homocysteine to produce cystathionine and water. Cystathionine 164-177 cystathionine beta-synthase Homo sapiens 29-32 22002135-1 2011 Cystathionine beta synthase gene (CbetaS) catalyzes the condensation of homocysteine with serine, forming cystathionine by the transsulfuration pathway. Cystathionine 108-121 cystathionine beta-synthase Homo sapiens 0-28 21275900-2 2011 CBS catalyzes the pyridoxal 5"-phosphate (PLP)-dependent conversion of homocysteine in Cystathionine whilst CSE the pyridoxal 5"-phosphate (PLP)-dependent synthesis of L-cysteine from Cystathionine. Cystathionine 87-100 cystathionine beta-synthase Homo sapiens 0-3 21275900-2 2011 CBS catalyzes the pyridoxal 5"-phosphate (PLP)-dependent conversion of homocysteine in Cystathionine whilst CSE the pyridoxal 5"-phosphate (PLP)-dependent synthesis of L-cysteine from Cystathionine. Cystathionine 184-197 cystathionine beta-synthase Homo sapiens 0-3 21275900-2 2011 CBS catalyzes the pyridoxal 5"-phosphate (PLP)-dependent conversion of homocysteine in Cystathionine whilst CSE the pyridoxal 5"-phosphate (PLP)-dependent synthesis of L-cysteine from Cystathionine. Cystathionine 184-197 cystathionine gamma-lyase Homo sapiens 108-111 21081698-2 2010 CBS catalyzes beta-replacement reactions of either serine or cysteine by homocysteine to give cystathionine and water or H(2)S, respectively. Cystathionine 94-107 Cystathionine beta-synthase Drosophila melanogaster 0-3 20638879-1 2010 Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase. Cystathionine 97-110 cystathionine beta-synthase Mus musculus 29-32 20638879-1 2010 Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase. Cystathionine 97-110 cystathionase (cystathionine gamma-lyase) Mus musculus 152-177 18776696-1 2008 Human cystathionine beta-synthase (CBS) catalyzes a pyridoxal 5"-phosphate (PLP) dependent beta-replacement reaction to synthesize cystathionine from serine and homocysteine. Cystathionine 6-19 pyridoxal phosphatase Homo sapiens 76-79 20067586-3 2010 Cystathionine beta-synthase (EC 4.2.1.22), and cystathionine gamma-lyase (CSE; EC 4.4.1.1), also known as cystathionine, can generate H(2)S from cyst(e)ine. Cystathionine 47-60 cystathionase (cystathionine gamma-lyase) Mus musculus 74-77 20035290-5 2009 L-cysteine, NAc-L-cysteine and D,L-homocysteine enhanced AA-induced serine/threonine phosphorylation and the translocation of cytosolic compounds to the cell membrane, but L-cystathionine had opposite effects. Cystathionine 172-187 synuclein alpha Homo sapiens 12-15 19715455-4 2009 The in vitro assay used HTMS to quantify the unlabeled product of the CBS reaction, cystathionine. Cystathionine 84-97 cystathionine beta-synthase Homo sapiens 70-73 19296828-5 2009 LmjCBS (L. major CBS) catalyses the synthesis of cystathionine from homocysteine, but, unlike mammalian CBS, also has high cysteine synthase activity (but with the Km for sulfide being 10.7 mM). Cystathionine 49-62 cystathionine beta-synthase Homo sapiens 3-6 19296828-5 2009 LmjCBS (L. major CBS) catalyses the synthesis of cystathionine from homocysteine, but, unlike mammalian CBS, also has high cysteine synthase activity (but with the Km for sulfide being 10.7 mM). Cystathionine 49-62 cystathionine beta-synthase Homo sapiens 17-20 19374684-1 2009 Hydrogen sulfide (H(2)S) is a well known and pungent toxic gas that has recently been shown to be synthesised in man from the amino acids cystathionine, homocysteine and cysteine by at least two distinct enzymes; cystathionine-gamma-lyase and cystathionine-beta-synthase. Cystathionine 138-151 cystathionine gamma-lyase Homo sapiens 213-238 19374684-1 2009 Hydrogen sulfide (H(2)S) is a well known and pungent toxic gas that has recently been shown to be synthesised in man from the amino acids cystathionine, homocysteine and cysteine by at least two distinct enzymes; cystathionine-gamma-lyase and cystathionine-beta-synthase. Cystathionine 138-151 cystathionine beta-synthase Homo sapiens 243-270 20155941-2 2010 CBS is a pyridoxal-5"-phosphate-dependent heme enzyme with cysteine and histidine axial ligands that catalyzes the condensation of serine and homocysteine to form cystathionine. Cystathionine 163-176 cystathionine beta-synthase Homo sapiens 0-3 19722721-2 2009 CBS contains a pyridoxal 5"-phosphate (PLP) cofactor which catalyzes the synthesis of cystathionine from homocysteine and serine. Cystathionine 86-99 pyridoxal phosphatase Homo sapiens 39-42 19486201-1 2009 Cystathionine gamma-lyase (CSE) is a key enzyme in the trans-sulphuration pathway for the biosynthesis of cysteine from methionine and catalyses the hydrolysis of cystathionine into cysteine. Cystathionine 163-176 cystathionine gamma-lyase Homo sapiens 0-25 19486201-1 2009 Cystathionine gamma-lyase (CSE) is a key enzyme in the trans-sulphuration pathway for the biosynthesis of cysteine from methionine and catalyses the hydrolysis of cystathionine into cysteine. Cystathionine 163-176 cystathionine gamma-lyase Homo sapiens 27-30 19424622-1 2009 The cystathionine beta-synthase (CBS) gene encodes an enzyme that catalyzes the synthesis of cystathionine in the trans-sulfuration pathway and is subject to tight regulation because of its critical role in antioxidant and methylation metabolism. Cystathionine 4-17 cystathionine beta-synthase Homo sapiens 33-36 19010420-1 2009 Cystathionine beta-synthase (CBS) catalyzes the pyridoxal-50-phosphate-dependent condensation of L-serine and L-homocysteine to form L-cystathionine in the first step of the transsulfuration pathway. Cystathionine 133-148 cystathionine beta-synthase Homo sapiens 0-27 19010420-1 2009 Cystathionine beta-synthase (CBS) catalyzes the pyridoxal-50-phosphate-dependent condensation of L-serine and L-homocysteine to form L-cystathionine in the first step of the transsulfuration pathway. Cystathionine 133-148 cystathionine beta-synthase Homo sapiens 29-32 19107218-5 2008 When the substrates for CBS, homocysteine and serine for cystathionine generation and homocysteine and cysteine for H(2)S generation, are added to the sumoylation mixture, they inhibit the sumoylation reaction, but only in the absence of hPc2. Cystathionine 57-70 cystathionine beta-synthase Homo sapiens 24-27 19107218-6 2008 Similarly, the product of the CBS reaction, cystathionine, inhibits sumoylation in the absence of hPc2. Cystathionine 44-57 cystathionine beta-synthase Homo sapiens 30-33 19107218-6 2008 Similarly, the product of the CBS reaction, cystathionine, inhibits sumoylation in the absence of hPc2. Cystathionine 44-57 chromobox 4 Homo sapiens 98-102 17337535-8 2007 With cystathionine, methanethiol production was detected from the CBL overexpression variant and complementation of the CBL-null mutant, implying that CBL may be involved in the conversion of cystathionine to methanethiol. Cystathionine 5-18 LHE_RS13155 Lactobacillus helveticus CNRZ32 66-69 17956124-1 2007 Cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent enzyme that catalyzes the condensation of serine and homocysteine to form cystathionine. Cystathionine 146-159 cystathionine beta-synthase Homo sapiens 0-27 17956124-1 2007 Cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent enzyme that catalyzes the condensation of serine and homocysteine to form cystathionine. Cystathionine 146-159 cystathionine beta-synthase Homo sapiens 29-32 18048956-3 2007 CT treatment reversed the changes in renal concentrations of non-protein thiols (NPSH), reactive oxygen species (ROS), sulfane sulfur and activities of rhodanese, cystathionase and glutathione S-transferase (GST) in tumor-bearing mice, which returned to the level observed in healthy animals. Cystathionine 0-2 hematopoietic prostaglandin D synthase Mus musculus 181-206 18048956-3 2007 CT treatment reversed the changes in renal concentrations of non-protein thiols (NPSH), reactive oxygen species (ROS), sulfane sulfur and activities of rhodanese, cystathionase and glutathione S-transferase (GST) in tumor-bearing mice, which returned to the level observed in healthy animals. Cystathionine 0-2 hematopoietic prostaglandin D synthase Mus musculus 208-211 17537983-5 2007 The higher renal CBS activity in males (22.7 +/- 3.1 mmol cystathionine.h(-1).kg kidney(-1)) vs. females (8.4 +/- 3.4 mmol cystathionine.h(-1).kg kidney(-1), P < or = 10(-6)) in C57Bl/6J mice was associated with lower plasma tHcy levels in males vs. females, and this difference was exacerbated in Cbs+/- mice (7.7 +/- 1.9 micromol/l in males vs. 13.8 +/- 6.4 micromol/l in females, P = 0.005). Cystathionine 58-71 cystathionine beta-synthase Mus musculus 17-20 17461778-7 2007 The conversion of homocysteine into cystathionine, a rate-limiting step in trans-sulfuration catalysed by cystathionine beta-synthase, was comparatively less efficient in the old mice, as indicated by cystathionine/homocysteine ratios. Cystathionine 36-49 cystathionine beta-synthase Mus musculus 106-133 17663144-1 2007 CBS is a vitamin B6-dependent transsulfuration enzyme needed to synthesize cysteine from methionine, catalyzing the condensation of serine with homocysteine to form cystathionine. Cystathionine 165-178 cystathionine beta-synthase Mus musculus 0-3 17855772-12 2007 Transfection of endothelial cells with cystathionine-beta-synthase (CBS) gene construct, which converts Hcy to cystathionine, reduced Hcy accumulation in high methionine-fed cells. Cystathionine 39-52 cystathionine beta-synthase Homo sapiens 68-71 17537983-5 2007 The higher renal CBS activity in males (22.7 +/- 3.1 mmol cystathionine.h(-1).kg kidney(-1)) vs. females (8.4 +/- 3.4 mmol cystathionine.h(-1).kg kidney(-1), P < or = 10(-6)) in C57Bl/6J mice was associated with lower plasma tHcy levels in males vs. females, and this difference was exacerbated in Cbs+/- mice (7.7 +/- 1.9 micromol/l in males vs. 13.8 +/- 6.4 micromol/l in females, P = 0.005). Cystathionine 123-136 cystathionine beta-synthase Mus musculus 17-20 17337535-8 2007 With cystathionine, methanethiol production was detected from the CBL overexpression variant and complementation of the CBL-null mutant, implying that CBL may be involved in the conversion of cystathionine to methanethiol. Cystathionine 192-205 LHE_RS13155 Lactobacillus helveticus CNRZ32 66-69 17337535-8 2007 With cystathionine, methanethiol production was detected from the CBL overexpression variant and complementation of the CBL-null mutant, implying that CBL may be involved in the conversion of cystathionine to methanethiol. Cystathionine 192-205 LHE_RS13155 Lactobacillus helveticus CNRZ32 120-123 17337535-8 2007 With cystathionine, methanethiol production was detected from the CBL overexpression variant and complementation of the CBL-null mutant, implying that CBL may be involved in the conversion of cystathionine to methanethiol. Cystathionine 192-205 LHE_RS13155 Lactobacillus helveticus CNRZ32 120-123 17004132-2 2006 Formed homocysteine is either catabolized into cystathionine (transsulfuration pathway) by cystathionine beta-synthase, or remethylated into methionine (remethylation pathway) by methionine synthase. Cystathionine 47-60 cystathionine beta-synthase Homo sapiens 91-118 17352495-1 2007 Cystathionine beta-synthase catalyzes the condensation of serine and homocysteine to yield cystathionine and is the single most common locus of mutations associated with homocystinuria. Cystathionine 91-104 cystathionine beta-synthase Homo sapiens 0-27 16953589-1 2006 Cystathionine beta-synthase (CBS) is a tetrameric heme protein that catalyzes the PLP-dependent condensation of serine and homocysteine to cystathionine. Cystathionine 139-152 cystathionine beta-synthase Homo sapiens 0-27 16953589-1 2006 Cystathionine beta-synthase (CBS) is a tetrameric heme protein that catalyzes the PLP-dependent condensation of serine and homocysteine to cystathionine. Cystathionine 139-152 cystathionine beta-synthase Homo sapiens 29-32 16953589-1 2006 Cystathionine beta-synthase (CBS) is a tetrameric heme protein that catalyzes the PLP-dependent condensation of serine and homocysteine to cystathionine. Cystathionine 139-152 proteolipid protein 1 Homo sapiens 82-85 16946488-1 2006 Cystathionine gamma-lyase (CSE) is the last key enzyme in the transsulfuration pathway for the biosynthesis of cysteine from methionine in mammals, and catalyzes the hydrolysis of cystathionine into cysteine. Cystathionine 180-193 cystathionase (cystathionine gamma-lyase) Mus musculus 0-25 16946488-1 2006 Cystathionine gamma-lyase (CSE) is the last key enzyme in the transsulfuration pathway for the biosynthesis of cysteine from methionine in mammals, and catalyzes the hydrolysis of cystathionine into cysteine. Cystathionine 180-193 cystathionase (cystathionine gamma-lyase) Mus musculus 27-30 16946488-8 2006 Serum concentrations of homocysteine (the precursor of cystathionine) were significantly lower in G18.5 dams than in virgins or G15.5 dams, suggesting that the expression of CSE in the kidneys contributes to the effective clearance of homocysteine during the late gestational stage. Cystathionine 55-68 cystathionase (cystathionine gamma-lyase) Mus musculus 174-177