PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
1302569-1	1992	Cortisol is metabolized to 6 beta-hydroxycortisol by the human cytochrome P-450 3A4, an enzyme implicated in the critical epoxidation reactions of aflatoxin B1 and certain polycyclic aromatic hydrocarbons.	6 beta-hydroxycortisol	27-49	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	63-83
34880651-5	2021	The activity of CYP3A4 isoenzyme was measured as the ratio of the concentrations of cortisol and 6beta-hydroxycortisol.	6 beta-hydroxycortisol	97-118	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	16-22
1819871-0	1991	Effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor pravastatin on urinary 6 beta-hydroxycortisol excretion: a preliminary study.	6 beta-hydroxycortisol	91-113	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	10-57
1800391-1	1991	Urinary 6 beta-hydroxycortisol (6 beta OHF) is a specific marker of the induction of the cytochrome P-450 IIIA.	6 beta-hydroxycortisol	8-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-105
34664787-0	2021	Studies on CYP3A activity during the menstrual cycle as measured by urinary 6beta-hydroxycortisol/cortisol.	6 beta-hydroxycortisol	76-97	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	11-16
34664787-1	2021	The 6beta-OH-cortisol/cortisol ratio (6beta-OHC/C) in urine is an endogenous marker of drug-metabolizing enzyme cytochrome P450 3A (CYP3A).	6 beta-hydroxycortisol	4-21	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	112-130
34664787-1	2021	The 6beta-OH-cortisol/cortisol ratio (6beta-OHC/C) in urine is an endogenous marker of drug-metabolizing enzyme cytochrome P450 3A (CYP3A).	6 beta-hydroxycortisol	4-21	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	132-137
2500346-3	1989	Cytochrome P-450 activity was monitored by measuring urinary 6-beta-hydroxycortisol output and systemic antipyrine clearance.	6 beta-hydroxycortisol	61-83	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
34674508-5	2021	Results: The CS group showed higher serum levels of 11-deoxycortisol than the NFA group, and increased levels of tetrahydrocortisone (THE), 20alpha-dihydrocortisol, and 6beta-hydroxycortisol were found in the PA group.	6 beta-hydroxycortisol	169-190	citrate synthase	Homo sapiens	13-15
35589097-1	2022	The feasibility of taking the ratio of 6beta-hydroxycortisol (6beta-OHCOR) to cortisol (COR) in plasma as a biomarker to reflect CYP3A4 activity needs to be verified, but the low concentration of 6beta-OHCOR which is an endogenous substance in plasma presents a challenge for determination.	6 beta-hydroxycortisol	39-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	129-135
34390638-6	2021	The activity of CYP3A4 isoenzyme was measured as the ratio of the concentrations of 6beta-hydroxycortisol and cortisol.	6 beta-hydroxycortisol	84-105	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	16-22
34390638-8	2021	Carriers of TT allelic variant polymorphism ABCB1 rs4148738 had a higher concentration of the 6-beta-hydroxycortisol in urine compared to CC and CT variants 3,467.35 +- 1,055.53 vs. 3,453.52 +- 1,516.89 vs. 2,593.30 +- 1,172.52 (p=0.029).	6 beta-hydroxycortisol	94-116	ATP binding cassette subfamily B member 1	Homo sapiens	44-49
4029252-3	1985	In all patients the oxidative cytochrome P-450 dependent drug metabolism was induced as shown by an increase of antipyrine-clearance from 36.3 +/- 8.8 to 80.6 +/- 20.1 ml/min and an enhanced urinary excretion of 6-beta-hydroxycortisol from 454 +/- 1.99 to 1607 +/- 362 micrograms/24 h. Furthermore, in all 6 patients the serum alkaline phosphatase declined.	6 beta-hydroxycortisol	212-234	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	30-46
4308754-0	1969	[Levels of urinary 6-beta-hydroxycortisol and other polar corticosteroids in children with severe diseases and its fluctuation by ACTH loading].	6 beta-hydroxycortisol	19-41	proopiomelanocortin	Homo sapiens	130-134
33622083-8	2021	CONCLUSION: Possible relationship between the CYP3A activity, evaluated by the content of the urinary endogenous substrate of the given isoenzyme and its metabolite, the 6-beta-hydroxy cortisol (6-beta-HC) / cortisol ratio, and the efficacy of diazepam was demonstrated.	6 beta-hydroxycortisol	170-193	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	46-51
4308676-0	1969	[Urinary excretion of 6-beta-hydroxycortisol and other polar corticosteroids in puberty and its changes by ACTH loading].	6 beta-hydroxycortisol	22-44	proopiomelanocortin	Homo sapiens	107-111
33622083-8	2021	CONCLUSION: Possible relationship between the CYP3A activity, evaluated by the content of the urinary endogenous substrate of the given isoenzyme and its metabolite, the 6-beta-hydroxy cortisol (6-beta-HC) / cortisol ratio, and the efficacy of diazepam was demonstrated.	6 beta-hydroxycortisol	195-204	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	46-51
32112986-10	2020	The activity of CYP3A was evaluated using the HPLC-MS/MS method by the content of the endogenous substrate of the given isoenzyme and its metabolite in urine (6- beta-hydroxy-cortisol/cortisol).	6 beta-hydroxycortisol	159-183	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	16-21
32112986-17	2020	In addition, we revealed the relationship between the CYP3A enzymatic activity (as evaluated by 6-beta-hydroxycortisol/ cortisol ratio measurement) and the miR-27b plasma concentration: rs = -0.27, p = 0.006.	6 beta-hydroxycortisol	96-118	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	54-59
31721244-3	2020	METHODS: A random forest (RF) algorithm which incorporated an endogenous CYP3A4 phenotype (assessed by urinary ratio of 6beta-hydroxycortisol and 6beta-hydroxycortisone to cortisol and cortisone), CYP3A5*3 genotype and other clinical determinants of tacrolimus disposition was performed in 182 medically stable renal transplant recipients.	6 beta-hydroxycortisol	120-141	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	73-79
32112986-17	2020	In addition, we revealed the relationship between the CYP3A enzymatic activity (as evaluated by 6-beta-hydroxycortisol/ cortisol ratio measurement) and the miR-27b plasma concentration: rs = -0.27, p = 0.006.	6 beta-hydroxycortisol	96-118	microRNA 27b	Homo sapiens	156-163
30607725-2	2018	6beta-hydroxycortisol, formed during CYP3A4-dependent electrocatalysis, has a characteristic fluorescent peak at lambda = 427 +- 2 nm after treating with the sulfuric acid : ethanol (3 : 1) mixture and excitation at lambda = 365 nm, which is different from the substrate (hydrocortisone) fluorescence (lambda = 525 +- 2 nm).	6 beta-hydroxycortisol	0-21	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	37-43
31102151-3	2019	The activity of CYP3A4/5 was expressed as the ratio of the concentrations of cortisol and 6beta-hydroxycortisol was performed by using high performance liquid chromatography.	6 beta-hydroxycortisol	90-111	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	16-22
30683357-0	2019	Assessment of electrocatalytic hydroxylase activity of cytochrome P450 3A4 (CYP3A4) by means of derivatization of 6beta-hydroxycortisol by sulfuric acid for fluorimetric assay.	6 beta-hydroxycortisol	114-135	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	55-74
30683357-0	2019	Assessment of electrocatalytic hydroxylase activity of cytochrome P450 3A4 (CYP3A4) by means of derivatization of 6beta-hydroxycortisol by sulfuric acid for fluorimetric assay.	6 beta-hydroxycortisol	114-135	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	76-82
29950882-9	2018	Median metabolic ratios 6beta-hydroxycortisol/cortisol (25%-75% percentiles) were 2.84 (1.99-4.39) for CYP2C19 extensive metabolizers (EMs), 2.51 (1.86-4.73) for CYP2C19 ultra-rapid metabolizers (UMs), and 1.45 (1.12-2.16) for CYP2C19 intermediate metabolizers (IMs) + poor metabolizers (PMs).	6 beta-hydroxycortisol	24-45	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	103-110
29606886-10	2018	CYP3A isoenzyme group activity was evaluated by determining urinary concentration of endogenous substrate of the enzyme and its metabolite (6-beta-hydroxycortisol to cortisol ratio).	6 beta-hydroxycortisol	140-162	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-5
29780235-5	2018	In clinical practice, the process of phenotyping of CYP isoenzymes and some endogenous substrates in the ratio of cortisol to 6beta-hydroxycortisol in urine for the evaluation of CYP3A4 activity has been deemed to be a quite promising, safe and minimally invasive method for patients nowadays.	6 beta-hydroxycortisol	126-147	peptidylprolyl isomerase G	Homo sapiens	52-55
29780235-5	2018	In clinical practice, the process of phenotyping of CYP isoenzymes and some endogenous substrates in the ratio of cortisol to 6beta-hydroxycortisol in urine for the evaluation of CYP3A4 activity has been deemed to be a quite promising, safe and minimally invasive method for patients nowadays.	6 beta-hydroxycortisol	126-147	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	179-185
27317471-0	2016	Urinary 6beta-Hydroxycortisol/Cortisol Ratio Most Highly Correlates With Midazolam Clearance Under Hepatic CYP3A Inhibition and Induction in Females: A Pharmacometabolomics Approach.	6 beta-hydroxycortisol	8-29	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	107-112
29343979-5	2018	The activity of CYP3A was evaluated by determining the concentrations of an endogenous substrate of this isoenzyme (cortisol) and its urinary metabolite (6-beta-hydroxycortisol, 6-B-HC).	6 beta-hydroxycortisol	154-176	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	16-21
28787271-7	2017	CYP2D6 and CYP3A were phenotyped with HPLC-MS using the concentration of endogenous substrate of the enzyme and its urinary metabolites [6-hydroxy-1,2,3,4-tetrahydro-beta-carboline(6-HO-THBC) to pinoline ratio for CYP2D6 and 6-beta-hydroxycortisol to cortisol ratio for CYP3A].	6 beta-hydroxycortisol	225-247	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6
28787271-7	2017	CYP2D6 and CYP3A were phenotyped with HPLC-MS using the concentration of endogenous substrate of the enzyme and its urinary metabolites [6-hydroxy-1,2,3,4-tetrahydro-beta-carboline(6-HO-THBC) to pinoline ratio for CYP2D6 and 6-beta-hydroxycortisol to cortisol ratio for CYP3A].	6 beta-hydroxycortisol	225-247	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	11-16
28157069-7	2017	We monitored CYP2C9 and CYP3A activities over their clinical courses by measuring the metabolic clearance of S-warfarin to S-7-hydroxywarfarin and that of cortisol to 6beta-hydroxycortisol, respectively.	6 beta-hydroxycortisol	167-188	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	13-19
28157069-7	2017	We monitored CYP2C9 and CYP3A activities over their clinical courses by measuring the metabolic clearance of S-warfarin to S-7-hydroxywarfarin and that of cortisol to 6beta-hydroxycortisol, respectively.	6 beta-hydroxycortisol	167-188	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	24-29
29075133-3	2017	CYP3A4 isoenzyme activity was determined by urine cortisol and 6-beta-hydroxycortisol levels.	6 beta-hydroxycortisol	63-85	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
29075133-5	2017	RESULTS: Low mean 6-beta-hydroxycortisol/cortisol ratio is indicative of impaired CYP3A4 activity and was associated with higher risk of thrombosis (b coefficient=0.022, SE 0.009, p=0.021 in the linear regression model).	6 beta-hydroxycortisol	18-40	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	82-88
27317471-7	2016	Of the urine and plasma metabolites measured, the 6beta-hydroxycortisol/cortisol ratio was most significantly correlated with midazolam clearance during hepatic CYP3A inhibition and induction.	6 beta-hydroxycortisol	50-71	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	161-166
27582327-8	2016	The activities of cytochrome P450 (CYP) 1A2, CYP2D6, CYP3A, xanthine oxidase (XO) and N-acetyltransferase 2 (NAT2) were assessed based on the urinary metabolic indices of caffeine and dextromethorphan, and the urinary excretion ratio of 6beta-hydroxycortisol to cortisol.	6 beta-hydroxycortisol	237-258	N-acetyltransferase 2	Homo sapiens	109-113
27317471-8	2016	Our results suggest that the urinary 6beta-hydroxycortisol/cortisol ratio is the best predictor of hepatic CYP3A activity under both maximal inhibition and maximal induction.	6 beta-hydroxycortisol	37-58	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	107-112
27317471-9	2016	Furthermore, the predictive model including 6beta-hydroxycortisol/cortisol as a covariate could be applied to predict the magnitude of CYP3A-mediated drug interactions.	6 beta-hydroxycortisol	44-65	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	135-140
26924289-3	2016	The endogenous CYP3A4 phenotype was assessed by the ratio of 6beta-hydroxycortisol and 6beta-hydroxycortisone to cortisol and cortisone in urine.	6 beta-hydroxycortisol	61-82	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	15-21
26399557-2	2016	The biomarkers 4beta-hydroxycholesterol (4betaHC) and 6beta-hydroxycortisol (6betaHCL) are sensitive to CYP3A induction and inhibition.	6 beta-hydroxycortisol	54-75	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	104-109
26399557-2	2016	The biomarkers 4beta-hydroxycholesterol (4betaHC) and 6beta-hydroxycortisol (6betaHCL) are sensitive to CYP3A induction and inhibition.	6 beta-hydroxycortisol	77-85	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	104-109
26399557-4	2016	We investigated whether endogenous plasma biomarkers (4betaHC and 6betaHCL) are associated with basal CYP3A metabolic activity in healthy subjects assessed by a convenient single-time-point oral midazolam (MDZ) phenotyping strategy.	6 beta-hydroxycortisol	66-74	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	102-107
26150050-0	2015	Evaluation of 6beta-Hydroxycortisol and 6beta-Hydroxycortisone as Biomarkers for Cytochrome P450 3A Activity: Insight into Their Predictive Value for Estimating Oral Immunosuppressant Metabolism.	6 beta-hydroxycortisol	14-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-99
26819743-5	2015	Serum drug concentrations and urinary levels of endogenous cortisol (F) and 6 beta-hydroxycortisol (6betaOHF), the metabolite of F by CYP3A4, were measured, and evaluated 6betaOHF/F ratio as a CYP3A4 activity marker.	6 beta-hydroxycortisol	76-98	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	134-140
26150050-1	2015	The combined clearance of endogenous 6beta-hydroxycortisol and 6beta-hydroxycortisone is suggested biomarker for in vivo cytochrome P450 3A (CYP3A) activity.	6 beta-hydroxycortisol	37-58	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	121-139
26150050-1	2015	The combined clearance of endogenous 6beta-hydroxycortisol and 6beta-hydroxycortisone is suggested biomarker for in vivo cytochrome P450 3A (CYP3A) activity.	6 beta-hydroxycortisol	37-58	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	141-146
26150050-6	2015	The combined clearance of 6beta-hydroxycortisol and 6beta-hydroxycortisone correlated significantly with cyclosporine pharmacokinetics (p < 0.001) after oral dose of a BCS 1 formulation, whereas no relationships were seen after administration of tacrolimus and sirolimus formulations, both of which belonged to BCS 2.	6 beta-hydroxycortisol	26-47	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	171-176
26150050-6	2015	The combined clearance of 6beta-hydroxycortisol and 6beta-hydroxycortisone correlated significantly with cyclosporine pharmacokinetics (p < 0.001) after oral dose of a BCS 1 formulation, whereas no relationships were seen after administration of tacrolimus and sirolimus formulations, both of which belonged to BCS 2.	6 beta-hydroxycortisol	26-47	PR/SET domain 5	Homo sapiens	314-319
26639694-14	2015	Determination of CYP3A4 activity was performed using high performance liquid chromatography with mass spectrometry (HPLC/ MS) by determination of endogenous substrate of this isoenzyme and its metabolite in urine - the ratio: cortisol/6-beta-hydroxycortisol.	6 beta-hydroxycortisol	235-257	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	17-23
25407158-2	2015	The urinary ratio of 6-beta hydroxycortisol to cortisol (6betaHF : F) is a marker of CYP3A4 induction.	6 beta-hydroxycortisol	21-43	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	85-91
26639694-31	2015	LIMITATIONS OF THE STUDY: It should be noted that in this research the activity of CYP3A4 was determined using high performance liquid chromatography with mass spectrometry (HPLC/MS) by determination the ratio of cortisol/6-beta-hydroxycortisol for the fist time.	6 beta-hydroxycortisol	222-244	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	83-89
24611975-3	2014	The activity of CYP3A can be assessed by the urinary ratio of 6beta-hydroxycortisol to cortisol.	6 beta-hydroxycortisol	62-83	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	16-21
23404385-0	2013	Association between urinary 6beta-hydroxycortisol/cortisol ratio and CYP3A5 genotypes in a normotensive population.	6 beta-hydroxycortisol	28-49	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	69-75
24487120-0	2014	6beta-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects.	6 beta-hydroxycortisol	0-21	solute carrier family 22 member 8	Homo sapiens	145-149
24487120-0	2014	6beta-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects.	6 beta-hydroxycortisol	0-21	solute carrier family 22 member 8	Homo sapiens	150-157
24487120-1	2014	6beta-Hydroxycortisol (6beta-OHF) is a substrate of the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins MATE1 and MATE-2K in the corresponding cDNA-transfected cells.	6 beta-hydroxycortisol	0-21	solute carrier family 22 member 8	Homo sapiens	56-83
24487120-1	2014	6beta-Hydroxycortisol (6beta-OHF) is a substrate of the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins MATE1 and MATE-2K in the corresponding cDNA-transfected cells.	6 beta-hydroxycortisol	0-21	solute carrier family 22 member 8	Homo sapiens	85-89
24487120-1	2014	6beta-Hydroxycortisol (6beta-OHF) is a substrate of the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins MATE1 and MATE-2K in the corresponding cDNA-transfected cells.	6 beta-hydroxycortisol	0-21	solute carrier family 47 member 1	Homo sapiens	138-143
24487120-1	2014	6beta-Hydroxycortisol (6beta-OHF) is a substrate of the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins MATE1 and MATE-2K in the corresponding cDNA-transfected cells.	6 beta-hydroxycortisol	0-21	solute carrier family 47 member 2	Homo sapiens	148-155
23674608-5	2013	The CYP3A4 induction could be detected even at the lowest dose of rifampicin (10 mg) via the estimated midazolam clearance, the 4beta-hydroxycholesterol ratio (both P < 0.01), and the 6beta-hydroxycortisol ratio (P < 0.05).	6 beta-hydroxycortisol	187-208	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	4-10
23320986-9	2013	CONCLUSION: This study demonstrates the absence of common CYP3A4 variant alleles in Nepalese people residing in Bangladesh whereas Nepalese people carrying the CYP3A5*1/*1 genotype appear to show a significantly higher 6beta-hydroxycortisol/cortisol ratios compared to those with CYP3A5*3/*3 genotype.	6 beta-hydroxycortisol	219-240	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	160-166
23320986-9	2013	CONCLUSION: This study demonstrates the absence of common CYP3A4 variant alleles in Nepalese people residing in Bangladesh whereas Nepalese people carrying the CYP3A5*1/*1 genotype appear to show a significantly higher 6beta-hydroxycortisol/cortisol ratios compared to those with CYP3A5*3/*3 genotype.	6 beta-hydroxycortisol	219-240	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	280-286
23073666-0	2013	Effect of the fluoroquinolone antibacterial agent DX-619 on the apparent formation and renal clearances of 6beta-hydroxycortisol, an endogenous probe for CYP3A4 inhibition, in healthy subjects.	6 beta-hydroxycortisol	107-128	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	154-160
23073666-4	2013	6beta-hydroxycortisol uptake was determined in HEK293 cells expressing OAT1, OAT3, OCT2, MATE1, and MATE2-K.	6 beta-hydroxycortisol	0-21	potassium two pore domain channel subfamily K member 3	Homo sapiens	71-75
23073666-4	2013	6beta-hydroxycortisol uptake was determined in HEK293 cells expressing OAT1, OAT3, OCT2, MATE1, and MATE2-K.	6 beta-hydroxycortisol	0-21	solute carrier family 22 member 8	Homo sapiens	77-81
23073666-4	2013	6beta-hydroxycortisol uptake was determined in HEK293 cells expressing OAT1, OAT3, OCT2, MATE1, and MATE2-K.	6 beta-hydroxycortisol	0-21	POU class 2 homeobox 2	Homo sapiens	83-87
23073666-4	2013	6beta-hydroxycortisol uptake was determined in HEK293 cells expressing OAT1, OAT3, OCT2, MATE1, and MATE2-K.	6 beta-hydroxycortisol	0-21	solute carrier family 47 member 1	Homo sapiens	89-94
23073666-4	2013	6beta-hydroxycortisol uptake was determined in HEK293 cells expressing OAT1, OAT3, OCT2, MATE1, and MATE2-K.	6 beta-hydroxycortisol	0-21	solute carrier family 47 member 2	Homo sapiens	100-107
23073666-8	2013	6beta-hydroxycortisol was a substrate of OAT3 (K(m) = 183 +- 25 mumol/l), OCT2, MATE1, and MATE2-K.	6 beta-hydroxycortisol	0-21	solute carrier family 22 member 8	Homo sapiens	41-45
23073666-8	2013	6beta-hydroxycortisol was a substrate of OAT3 (K(m) = 183 +- 25 mumol/l), OCT2, MATE1, and MATE2-K.	6 beta-hydroxycortisol	0-21	POU class 2 homeobox 2	Homo sapiens	74-78
23073666-8	2013	6beta-hydroxycortisol was a substrate of OAT3 (K(m) = 183 +- 25 mumol/l), OCT2, MATE1, and MATE2-K.	6 beta-hydroxycortisol	0-21	solute carrier family 47 member 1	Homo sapiens	80-85
23073666-8	2013	6beta-hydroxycortisol was a substrate of OAT3 (K(m) = 183 +- 25 mumol/l), OCT2, MATE1, and MATE2-K.	6 beta-hydroxycortisol	0-21	solute carrier family 47 member 2	Homo sapiens	91-98
23162091-7	2013	RESULTS: We found a sharp increase in the excretion of 6beta-hydroxycortisol over cortisol (P < 0.001), indicative of a strong induction of the major drug-metabolizing enzyme cytochrome P450 3A4.	6 beta-hydroxycortisol	55-76	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	178-197
23404385-3	2013	The purpose of the present study was to study the associations of single nucleotide polymorphisms in the CYP3A5 gene with the urinary 6beta-hydroxycortisol/cortisol (6beta-OH-CS/CS) ratio considered as quantitative phenotypes.	6 beta-hydroxycortisol	134-155	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	105-111
23404385-3	2013	The purpose of the present study was to study the associations of single nucleotide polymorphisms in the CYP3A5 gene with the urinary 6beta-hydroxycortisol/cortisol (6beta-OH-CS/CS) ratio considered as quantitative phenotypes.	6 beta-hydroxycortisol	166-177	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	105-111
23404385-16	2013	This is the first study to report the genetic polymorphism of CYP3A5 in a North Indian population and its association with urinary 6beta-OH-CS/CS ratio reflecting the CYP3A phenotypes.	6 beta-hydroxycortisol	131-142	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	62-68
23404385-16	2013	This is the first study to report the genetic polymorphism of CYP3A5 in a North Indian population and its association with urinary 6beta-OH-CS/CS ratio reflecting the CYP3A phenotypes.	6 beta-hydroxycortisol	131-142	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	62-67
22120734-6	2012	CYP3A4 enzyme activity in urine samples was assessed through determination of 6beta-hydroxycortisol/cortisol free ratio (6betaOHC/FC).	6 beta-hydroxycortisol	78-99	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
21114969-7	2011	Two samples heterozygous for CYP3A4*1B (1.0%) and twenty six samples with the genotype CYP3A5*1/*1 (13.0%) were found to have relatively high 6beta-hydroxy-cortisol/cortisol ratios.	6 beta-hydroxycortisol	142-164	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	87-93
22741198-2	2012	The activity of cytochrome P450 isoenzyme CYP3A4 was estimated by the ratio of 6-beta-hydroxycortisol and cortisol.	6 beta-hydroxycortisol	79-101	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	42-48
21490593-2	2011	The aim of this study was to determine whether formation clearance (CL(f)) of the sum of 6beta-hydroxycortisol and 6beta-hydroxycortisone is a useful probe of CYP3A4 inhibition in vivo.	6 beta-hydroxycortisol	89-110	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	159-165
21490593-3	2011	In human liver microsomes (HLMs), the formation of 6beta-hydroxycortisol and 6beta-hydroxycortisone was catalyzed by CYP3A4, and itraconazole inhibited these reactions with half maximal inhibitory concentration (IC(50))(,u) values of 3.1 nmol/l and 3.4 nmol/l, respectively.	6 beta-hydroxycortisol	51-72	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	117-123
21490593-7	2011	Given the significant decrease in CL(f) of 6beta-hydroxycortisone and 6beta-hydroxycortisol after 200-mg and 400-mg single doses of itraconazole, this endogenous probe can be used to detect moderate and potent CYP3A4 inhibition in vivo.	6 beta-hydroxycortisol	70-91	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	210-216
16842393-1	2006	AIMS: A non-invasive proposed method for measuring CYP3A activity is the urinary 6beta-hydroxycortisol:cortisol ratio.	6 beta-hydroxycortisol	81-102	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	51-56
17371531-6	2007	Urine samples (0-24 hr) were collected for the analysis of 6beta-hydroxycortisol (biomarker for CYP3A4).	6 beta-hydroxycortisol	59-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	96-102
19959402-3	2010	The metabolic ratio (MR) of the concentration of 6beta-hydroxycortisol (6beta-OHC) to cortisol (MR 6beta-OHC/cortisol) in human urine had been proposed as an endogenous marker for CYP3A activity.	6 beta-hydroxycortisol	49-70	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	180-185
19690646-0	2007	Study of the Urinary Ratio of 6 beta-Hydroxycortisol/Cortisol as a Biomarker of CYP3A4 Activity in Egyptian Patients with Chronic Liver Diseases.	6 beta-hydroxycortisol	30-52	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	80-86
19690646-1	2007	The urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker of CYP3A4 metabolizing activity has been studied in Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection to determine any possible alteration in enzyme activity.	6 beta-hydroxycortisol	21-43	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	86-92
16842393-9	2006	Larger interindividual and intra-individual variability in CYP3A activity was observed in 6beta-hydroxycortisol:cortisol ratios compared with midazolam clearances.	6 beta-hydroxycortisol	90-111	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-64
15016124-1	2004	The urinary ratio of 6beta-hydroxycortisol to cortisol (6beta-OHF/F) is considered to be the simplest and most practical method for estimation of hepatic cytochrome P450 3A4 (CYP3A4) activity as a non-invasive marker of human in vivo CYP3A4 activity.	6 beta-hydroxycortisol	21-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	154-173
15726657-9	2005	In contrast, administration of rifampicin markedly induced CYP3A metabolism, resulting in abolished budesonide plasma levels and high urinary excretion of 6beta-hydroxycortisol.	6 beta-hydroxycortisol	155-176	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-64
15545313-1	2004	The present study determined the interindividual and intrandividual variability of the urinary 6beta-hydroxycortisol/cortisol ratio, a useful marker for CYP3A induction and inhibition in Chinese subjects.	6 beta-hydroxycortisol	95-116	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	153-158
15373933-9	2004	The urinary ratio of 6beta-hydroxycortisol to cortisol, which reflects CYP3A4 activity, also increased after dosing with SJW (ratio; 2.1 (95%CI 0.85-3.4)).	6 beta-hydroxycortisol	21-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	71-77
15365655-0	2004	Effects of growth hormone deficiency and rhGH replacement therapy on the 6beta-hydroxycortisol/free cortisol ratio, a marker of CYP3A activity, in growth hormone-deficient children.	6 beta-hydroxycortisol	73-94	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	128-133
15365655-3	2004	The urinary ratio 6beta-hydroxycortisol/free cortisol was used as a marker of CYP3A activity.	6 beta-hydroxycortisol	18-39	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	78-83
15298747-0	2004	Urinary 6beta-hydroxycortisol/17-hydroxycorticosteroids ratio as a measure of hepatic CYP3A4 capacity after enzyme induction.	6 beta-hydroxycortisol	8-29	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	86-92
15298747-1	2004	BACKGROUND: The correlation between the urinary 6beta-hydroxycortisol/17-hydroxycorticosteroids (6beta-OHF/17-OHCS) ratio and the metabolic capacity of the most abundant form of hepatic cytochrome P450 (CYP3A4) after induction remains unclear.	6 beta-hydroxycortisol	48-69	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	203-209
16433874-8	2006	CYP3A4 induction was assessed by ratios of urinary 6beta-hydroxycortisol : cortisol (6beta-OHC : C) obtained via 24 h and morning-spot sampling techniques.	6 beta-hydroxycortisol	51-72	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
16183337-0	2005	Simultaneous determination of 6beta-hydroxycortisol and cortisol in human urine and plasma by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity.	6 beta-hydroxycortisol	30-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	174-179
15657405-2	2005	We developed a novel method for estimating the interpatient variability of CYP3A4 activity by the urinary metabolite of exogenous cortisol (6-beta-hydroxycortisol [6-beta-OHF]).	6 beta-hydroxycortisol	140-162	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	75-81
15770075-12	2005	The urinary 6beta-hydroxycortisol/cortisol concentration ratio following ITZ administration for 7 consecutive days was about half of that before the start of ITZ administration, indicating that CYP3A4 metabolic activity was inhibited by administration of ITZ.	6 beta-hydroxycortisol	12-33	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	194-200
15016124-1	2004	The urinary ratio of 6beta-hydroxycortisol to cortisol (6beta-OHF/F) is considered to be the simplest and most practical method for estimation of hepatic cytochrome P450 3A4 (CYP3A4) activity as a non-invasive marker of human in vivo CYP3A4 activity.	6 beta-hydroxycortisol	21-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	175-181
15016124-1	2004	The urinary ratio of 6beta-hydroxycortisol to cortisol (6beta-OHF/F) is considered to be the simplest and most practical method for estimation of hepatic cytochrome P450 3A4 (CYP3A4) activity as a non-invasive marker of human in vivo CYP3A4 activity.	6 beta-hydroxycortisol	21-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	234-240
14605790-0	2003	Urinary 6beta-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals.	6 beta-hydroxycortisol	8-29	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	114-119
14751784-0	2004	Simultaneous determination of 6beta-hydroxycortisol and cortisol in human urine by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity determined by the cortisol 6beta-hydroxylation clearance.	6 beta-hydroxycortisol	30-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	163-168
14605865-12	2004	All subjects demonstrated a marked induction of hepatic microsomal CYP3A analyzed by the excretion ratio of 6beta-hydroxycortisol to cortisol from a mean baseline concentration of 5.6 U to 50.5 U.	6 beta-hydroxycortisol	108-129	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-72
14715379-1	2004	Cortisol is metabolized to 6beta-hydroxycortisol by human cytochrome p450-3A4 (CYP3A4), an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds.	6 beta-hydroxycortisol	27-48	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	58-77
14715379-1	2004	Cortisol is metabolized to 6beta-hydroxycortisol by human cytochrome p450-3A4 (CYP3A4), an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds.	6 beta-hydroxycortisol	27-48	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	79-85
14715379-8	2004	These results indicated that urinary 6beta-hydroxycortisol to cortisol ratios measured in a spot urine sample may reflect the level of this biomarker over a relatively longer time period in Caucasian women, and thus, it can be used in epidemiologic studies as a biomarker to evaluate the association between CYP3A4 activity and disease risk.	6 beta-hydroxycortisol	37-58	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	308-314
12787801-1	2003	While the urinary concentration ratio of 6beta-hydroxycortisol (6beta-HC) to cortisol (C) in 24-h urine samples is an established parameter for the induction of hepatic cytochrome P450 (CYP) 3A activity, it remains unclear whether it would be reduced in association with chronic liver damages.	6 beta-hydroxycortisol	41-62	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	169-193
14713367-3	2003	Twenty-six healthy subjects were studied to evaluate their baseline activity of CYP1A2 and XO by the respective urinary metabolic ratios of an 8-h urine sample after an oral 150-mg dose of caffeine and of CYP3A by a urinary excretion ratio of 6beta-hydroxycortisol (6beta-HC) to free cortisol (FC).	6 beta-hydroxycortisol	243-264	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
14713367-3	2003	Twenty-six healthy subjects were studied to evaluate their baseline activity of CYP1A2 and XO by the respective urinary metabolic ratios of an 8-h urine sample after an oral 150-mg dose of caffeine and of CYP3A by a urinary excretion ratio of 6beta-hydroxycortisol (6beta-HC) to free cortisol (FC).	6 beta-hydroxycortisol	266-274	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
12787801-1	2003	While the urinary concentration ratio of 6beta-hydroxycortisol (6beta-HC) to cortisol (C) in 24-h urine samples is an established parameter for the induction of hepatic cytochrome P450 (CYP) 3A activity, it remains unclear whether it would be reduced in association with chronic liver damages.	6 beta-hydroxycortisol	64-72	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	169-193
12463723-2	2002	The objective of this prospective, open-label study conducted in healthy volunteers was to evaluate the influence of multiple-dose pioglitazone therapy on the urinary excretion ratio of 6-beta-hydroxycortisol to cortisol, an endogenous marker of CYP3A4 activity.	6 beta-hydroxycortisol	186-208	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	246-252
12463723-5	2002	Baseline and posttreatment CYP3A4 activity was assessed with the urinary 6-beta-hydroxycortisol/cortisol ratio.	6 beta-hydroxycortisol	73-95	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	27-33
12463733-5	2002	In the course of modifying her anticonvulsant regimen, the authors examined the 6beta-hydroxycortisol/cortisol ratio (6beta-OHF/F) in her urine, which can be the index of hepatic CYP3A4 activity, with electrospray ionization/mass spectrometry/mass spectrometry (ESI/MS/MS).	6 beta-hydroxycortisol	80-101	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	179-185
11549205-1	2001	OBJECTIVE: The urinary ratio of 6beta-hydroxycortisol to cortisol is known as a possible marker of CYP3A4 activity.	6 beta-hydroxycortisol	32-53	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	99-105
12451288-1	2002	The frequency distribution of CYP3A activity was investigated by measuring ratios of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy subjects to determine whether a genetic polymorphism for this cytochrome enzyme exists in "native-born" Japanese persons.	6 beta-hydroxycortisol	93-114	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	30-35
12451288-6	2002	These results show that a CYP3A genetic polymorphism in Japanese persons, based on 6beta-hydroxycortisol excretions, likely does not exist, but there appears to be a broad unimodal distribution of enzyme activity in the population.	6 beta-hydroxycortisol	83-104	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	26-31
11303593-1	2001	The ratio of urinary 6beta-hydroxycortisol:cortisol is a measure of the activity of cytochrome p450 3A4 (CYP3A4).	6 beta-hydroxycortisol	21-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	84-103
11471773-3	2001	Two such tests of CYP3A activity are the midazolam plasma clearance after its intravenous administration and the 6beta-OH cortisol urinary ratio.	6 beta-hydroxycortisol	113-130	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	18-23
11303593-1	2001	The ratio of urinary 6beta-hydroxycortisol:cortisol is a measure of the activity of cytochrome p450 3A4 (CYP3A4).	6 beta-hydroxycortisol	21-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	105-111
10463384-0	1999	Increase in urinary excretion of 6beta-hydroxycortisol in common marmosets as a marker of hepatic CYP3A induction.	6 beta-hydroxycortisol	33-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	98-103
11181494-13	2001	When compared with healthy Chinese population data, the 6beta-hydroxycortisol to free cortisol ratio data suggested that these alleles (CYP3A4*4, CYP3A4*5, and CYP3A4*6) may decrease the CYP3A4 activity.	6 beta-hydroxycortisol	56-77	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	136-142
11181494-13	2001	When compared with healthy Chinese population data, the 6beta-hydroxycortisol to free cortisol ratio data suggested that these alleles (CYP3A4*4, CYP3A4*5, and CYP3A4*6) may decrease the CYP3A4 activity.	6 beta-hydroxycortisol	56-77	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	146-152
11129093-8	2000	Cytochrome P4503A4 (CYP3A4) inducibility was measured by comparing the urinary metabolic ratio of 6beta-hydroxycortisol/cortisol on day 14 and 19, Lymphocyte P-gp expression and activity was not induced by rifampicin, while it increased CYP3A4 activity from 5.0 +/- 4.0 to 22.9 +/- 16.6 (P < 0.001).	6 beta-hydroxycortisol	98-119	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-18
11129093-8	2000	Cytochrome P4503A4 (CYP3A4) inducibility was measured by comparing the urinary metabolic ratio of 6beta-hydroxycortisol/cortisol on day 14 and 19, Lymphocyte P-gp expression and activity was not induced by rifampicin, while it increased CYP3A4 activity from 5.0 +/- 4.0 to 22.9 +/- 16.6 (P < 0.001).	6 beta-hydroxycortisol	98-119	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	20-26
10975239-2	2000	The endogenous hormonal ratio of 6beta-hydroxycortisol (beta-OHF) to cortisol (F) in the urine is an index for metabolic enzyme activity of cytochrome p-450 (CYP) 3A4.	6 beta-hydroxycortisol	33-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	140-166
10824623-7	2000	Baseline and posttreatment CYP3A4 activity was assessed with the urinary 6-beta-hydroxycortisol/cortisol ratio after a 24-hour urine collection.	6 beta-hydroxycortisol	73-95	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	27-33
10611140-9	2000	This has been confirmed subsequently in a clinical study, with 6beta-hydroxycortisol/cortisol ratios as marker of CYP3A4 activity.	6 beta-hydroxycortisol	63-84	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	114-120
11522047-2	2001	To accomplish this goal, the in vivo activity of CYP3A was estimated by measuring the 24-hour urinary excretion of 6beta-hydroxycortisol (6beta-OHC) and by calculating 24-hour ratio of 6beta-hydroxycortisol to urinary free cortisol (6beta-OHC/UFC ratio).	6 beta-hydroxycortisol	115-136	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-54
11522047-2	2001	To accomplish this goal, the in vivo activity of CYP3A was estimated by measuring the 24-hour urinary excretion of 6beta-hydroxycortisol (6beta-OHC) and by calculating 24-hour ratio of 6beta-hydroxycortisol to urinary free cortisol (6beta-OHC/UFC ratio).	6 beta-hydroxycortisol	185-206	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-54
10805065-0	2000	Circadian variation of the urinary 6beta-hydroxycortisol to cortisol ratio that would reflect hepatic CYP3A activity.	6 beta-hydroxycortisol	35-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	102-107
10805065-2	2000	The aim of this study was to assess the intra-individual diurnal variation and day-to-day variation of the urinary 6beta-hydroxycortisol to cortisol ratio, a noninvasive index of human CYP3A activity.	6 beta-hydroxycortisol	115-136	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	185-190
10463384-1	1999	The ratio of urinary 6beta-hydroxycortisol (6beta-OHF) to free cortisol (F), i.e., the 6beta-OHF/F ratio, has been reported to be a specific marker for human CYP3A induction by in vivo studies of human subjects.	6 beta-hydroxycortisol	21-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	158-163
10234596-1	1999	A single spot urine collection to measure the ratio of 6 beta-hydroxycortisol (6 beta-OHC) to free cortisol (C) has been proposed as a research tool for the assessment of CYP3A4 induction.	6 beta-hydroxycortisol	55-77	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	171-177
10354961-1	1999	The urinary ratio of 6-beta-hydroxycortisol/cortisol has been used as a noninvasive probe for human cytochrome P450 3A4 isoforms (CYP3A4).	6 beta-hydroxycortisol	21-43	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	100-119
10354961-1	1999	The urinary ratio of 6-beta-hydroxycortisol/cortisol has been used as a noninvasive probe for human cytochrome P450 3A4 isoforms (CYP3A4).	6 beta-hydroxycortisol	21-43	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	130-136
9753209-3	1998	Known inducers of CYP3A, such as rifampin, phenytoin, carbamazepine, and phenobarbital, increase the urinary excretion of 6beta-hydroxycortisol and the ratio of 6beta-hydroxycortisol to cortisol.	6 beta-hydroxycortisol	122-143	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	18-23
10073736-1	1999	AIMS: To assess CYP3A enzyme activity in human neonates by measuring the urinary 6beta-hydroxycortisol/cortisol (6beta-OHF/C) ratio.	6 beta-hydroxycortisol	81-102	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	16-21
9855326-0	1998	Cytochrome P450 3A4 activity in premenopausal and postmenopausal women, based on 6-beta-hydroxycortisol:cortisol ratios.	6 beta-hydroxycortisol	81-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-19
9855326-1	1998	STUDY OBJECTIVE: To characterize cytochrome P450 (CYP) 3A4 activity in premenopausal and postmenopausal women by evaluating the urinary 6-beta-hydroxycortisol:cortisol ratio.	6 beta-hydroxycortisol	136-158	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	33-58
9855326-7	1998	CONCLUSION: Cytochrome P450 3A4 activity as measured by 6-beta-hydroxy cortisol:cortisol ratio did not differ by week of menstrual cycle, suggesting no menstrual cycle-related changes.	6 beta-hydroxycortisol	56-79	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	12-31
9753209-3	1998	Known inducers of CYP3A, such as rifampin, phenytoin, carbamazepine, and phenobarbital, increase the urinary excretion of 6beta-hydroxycortisol and the ratio of 6beta-hydroxycortisol to cortisol.	6 beta-hydroxycortisol	161-182	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	18-23
9492385-7	1998	A high CYP3A4 activity in the patient is consistent with the repeated administration of methylprednisolone for 14 days before paclitaxel treatment, a compound known to induce the CYP3A isoform, and with the increased ratio of 6beta-hydroxycortisol/cortisol in urine, an index of CYP3A activity.	6 beta-hydroxycortisol	226-247	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	7-13
9660842-8	1998	The 24-hr urinary recoveries of 6beta-hydroxycortisol were reduced by an average of 27% during nelfinavir treatment, consistent with CYP3A inhibition by nelfinavir.	6 beta-hydroxycortisol	32-53	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	133-138
9663175-0	1998	Urinary excretion of 6 beta-hydroxycortisol as an in vivo marker for CYP3A induction: applications and recommendations.	6 beta-hydroxycortisol	21-43	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	69-74
9663175-8	1998	CONCLUSIONS: Urinary excretion of 6 beta-hydroxycortisol may be useful as a screening tool in early-phase development to assess the potential for an investigational drug to induce CYP3A.	6 beta-hydroxycortisol	34-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	180-185
9492385-7	1998	A high CYP3A4 activity in the patient is consistent with the repeated administration of methylprednisolone for 14 days before paclitaxel treatment, a compound known to induce the CYP3A isoform, and with the increased ratio of 6beta-hydroxycortisol/cortisol in urine, an index of CYP3A activity.	6 beta-hydroxycortisol	226-247	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	7-12
9391787-10	1997	CONCLUSION: A fourfold increase of urinary 6-beta-hydroxycortisol output after induction of cytochrome P-450 by rifampicin is associated with a significant but less than 10% increase in human liver volume.	6 beta-hydroxycortisol	43-65	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	92-108
7917777-4	1994	Induction of the cytochrome P450 isoform, CYP3A, has been assessed in the same patients by measurement of the 24 h urinary excretion of 6 beta-hydroxycortisol by radioimmunoassay.	6 beta-hydroxycortisol	136-158	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	42-47
7858720-0	1994	Simultaneous determination of urinary free cortisol and 6 beta-hydroxycortisol by high-performance liquid chromatography to measure human CYP3A activity.	6 beta-hydroxycortisol	56-78	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	138-143
7858720-1	1994	The ratio of the hydrophilic metabolite 6 beta-hydroxycortisol to its parent compound cortisol has recently been demonstrated to be a specific marker for human CYP3A oxygenase activity.	6 beta-hydroxycortisol	40-62	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	160-165