PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21338149-0	2011	Mass spectrometry reveals that the antibiotic simocyclinone D8 binds to DNA gyrase in a "bent-over" conformation: evidence of positive cooperativity in binding.	simocyclinone D8	46-62	DNA topoisomerase II alpha	Homo sapiens	72-82
24060488-0	2013	Flavone-based analogues inspired by the natural product simocyclinone D8 as DNA gyrase inhibitors.	simocyclinone D8	56-72	DNA topoisomerase II alpha	Homo sapiens	76-86
24060488-3	2013	The natural product simocyclinone D8 (SD8) has been reported to inhibit DNA gyrase, a validated antibacterial drug target, by a unique catalytic inhibition mechanism of action.	simocyclinone D8	20-36	DNA topoisomerase II alpha	Homo sapiens	72-82
24060488-3	2013	The natural product simocyclinone D8 (SD8) has been reported to inhibit DNA gyrase, a validated antibacterial drug target, by a unique catalytic inhibition mechanism of action.	simocyclinone D8	38-41	DNA topoisomerase II alpha	Homo sapiens	72-82
21338149-2	2011	Here we present a mass spectrometry study of complexes formed between the A subunit of the topoisomerase DNA gyrase and the bifunctional inhibitor simocyclinone D8 (SD8), an antibiotic isolated from Streptomyces.	simocyclinone D8	147-163	DNA topoisomerase II alpha	Homo sapiens	105-115
21338149-2	2011	Here we present a mass spectrometry study of complexes formed between the A subunit of the topoisomerase DNA gyrase and the bifunctional inhibitor simocyclinone D8 (SD8), an antibiotic isolated from Streptomyces.	simocyclinone D8	165-168	DNA topoisomerase II alpha	Homo sapiens	105-115
30916622-3	2020	Hence, in this work, using Smina Autodock and through structure-based virtual screening of StreptomeDB, several natural products were discovered based on the SimocyclinoneD8 (SD8) binding pocket of GyrA subunit of DNA gyrase.	simocyclinone D8	158-173	DNA topoisomerase II alpha	Homo sapiens	214-224
15728908-0	2005	Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action.	simocyclinone D8	0-16	DNA topoisomerase II alpha	Homo sapiens	34-44