PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25845359-3	2015	We first designed artificially synthetic promoters with tandem copies of a single type of cis-element (SARE, JERE, GCC, GST1, HSRE, and W-box) that could mediate the expression of the beta-glucuronidase (GUS) reporter gene in plants upon PBZ treatment.	Tripelennamine	238-241	glucuronidase beta	Homo sapiens	184-202
2568728-14	1989	Pretreatment with PBZ significantly increased the SNS-evoked NA and NPY-LI overflow, while DMI enhanced both the functional response and NA release but reduced the NPY-LI overflow.	Tripelennamine	18-21	neuropeptide Y	Sus scrofa	68-71
22372713-1	2012	UV resonance Raman spectroscopy was used to characterize the binding of three first-generation histamine H(1) receptor antagonists-tripelennamine (TRP), mepyramine (MEP), and brompheniramine (BPA)-to human serum albumin (HSA) at pH 7.2 and pH 9.0.	Tripelennamine	131-145	histamine receptor H1	Homo sapiens	95-118
11180002-6	2001	The histamine H1 receptor antagonists diphenhydramine and tripelennamine accelerated the recovery.	Tripelennamine	58-72	histamine receptor H1	Mus musculus	4-25
9616188-1	1998	Classic antihistamines, namely diphenhydramine, chlorpheniramine, clemastine, perphenazine, hydroxyzine, and tripelennamine, share structural features with substrates and inhibitors of the polymorphic cytochrome P450 (CYP) isozyme CYP2D6.	Tripelennamine	109-123	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	201-216
8797856-1	1996	The amino acid p-benzoyl-L-phenylalanine, (p-Bz)Phe, has been incorporated into substance P (SP), Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, to localize the agonist-binding domains of the human neurokinin-1 (NK-1) receptor overexpressed in a transfected mammalian cell line.	Tripelennamine	42-48	tachykinin precursor 1	Homo sapiens	80-91
8797856-1	1996	The amino acid p-benzoyl-L-phenylalanine, (p-Bz)Phe, has been incorporated into substance P (SP), Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, to localize the agonist-binding domains of the human neurokinin-1 (NK-1) receptor overexpressed in a transfected mammalian cell line.	Tripelennamine	42-48	tachykinin precursor 1	Homo sapiens	93-95
8797856-1	1996	The amino acid p-benzoyl-L-phenylalanine, (p-Bz)Phe, has been incorporated into substance P (SP), Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, to localize the agonist-binding domains of the human neurokinin-1 (NK-1) receptor overexpressed in a transfected mammalian cell line.	Tripelennamine	42-48	tachykinin precursor 1	Homo sapiens	200-212
8797856-1	1996	The amino acid p-benzoyl-L-phenylalanine, (p-Bz)Phe, has been incorporated into substance P (SP), Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, to localize the agonist-binding domains of the human neurokinin-1 (NK-1) receptor overexpressed in a transfected mammalian cell line.	Tripelennamine	42-48	tachykinin receptor 1	Homo sapiens	214-228
35322828-5	2022	Eventually, the BL probe P-Bz-Luc was successfully applied for sensitive imaging of the ALP and GGT co-overexpressed fLuc-231 breast cancer cells and tumors, with the help of the coordination cleavage of P-Bz-Luc by ALP and GGT.	Tripelennamine	25-29	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	96-99
35322828-5	2022	Eventually, the BL probe P-Bz-Luc was successfully applied for sensitive imaging of the ALP and GGT co-overexpressed fLuc-231 breast cancer cells and tumors, with the help of the coordination cleavage of P-Bz-Luc by ALP and GGT.	Tripelennamine	25-29	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	224-227
35322828-5	2022	Eventually, the BL probe P-Bz-Luc was successfully applied for sensitive imaging of the ALP and GGT co-overexpressed fLuc-231 breast cancer cells and tumors, with the help of the coordination cleavage of P-Bz-Luc by ALP and GGT.	Tripelennamine	204-208	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	96-99
35322828-5	2022	Eventually, the BL probe P-Bz-Luc was successfully applied for sensitive imaging of the ALP and GGT co-overexpressed fLuc-231 breast cancer cells and tumors, with the help of the coordination cleavage of P-Bz-Luc by ALP and GGT.	Tripelennamine	204-208	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	224-227
9226736-1	1997	We previously demonstrated that combination of opioids, pentazocine and dihydrocodeine, with the histamine H1-receptor antagonists tripelennamine and chlorpheniramine could enhance their rewarding effects in rats.	Tripelennamine	131-145	histamine receptor H 1	Rattus norvegicus	97-118
8833423-1	1996	Previous studies have reported that the histamine H1 receptor blocker tripelennamine potentiates morphine withdrawal.	Tripelennamine	70-84	histamine receptor H1	Mus musculus	40-61
8833423-2	1996	In this paper, the in vivo effects produced by tripelennamine on the turnover of serotonin (5-HT), dopamine (DA) and noradrenaline (NA) in the whole brain, excluding the cerebellum, were studied in control, morphine-dependent (by SC implantation of a 75 mg morphine pellet) and morphine-dependent male CD1 mice just before naloxone-precipitated withdrawal.	Tripelennamine	47-61	CD1 antigen complex	Mus musculus	302-305
7628292-4	1995	However, expressed human UGT1.4 protein exhibited glucuronidation activity toward tertiary amine substrates, such as imipramine, cyproheptadine, tripelennamine, and chlorpromazine, which form quaternary ammonium-linked glucuronides.	Tripelennamine	145-159	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	25-31
1362943-5	1992	A polyclonal antibody preparation raised in sheep against rabbit liver p-nitrophenol UGT was found to inhibit tripelennamine glucuronidation in solubilized human liver microsomes, but had no effect on p-nitrophenol, 4-methylumbelliferone, 4-aminobiphenyl, estriol, morphine, or naloxone glucuronidation.	Tripelennamine	110-124	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	85-88
3253717-2	1988	For what concerns the effects on locomotor activity, it was demonstrated that three histamine H1 receptor antagonists, chlorpheniramine, diphenhydramine and tripelennamine enhance morphine-, but not amphetamine and scopolamine-induced hyperactivity in mice.	Tripelennamine	157-171	histamine receptor H1	Mus musculus	84-105
3522250-2	1986	Tripelennamine (H1 blocker) further enhanced renin secretion in the presence of exogenous histamine.	Tripelennamine	0-14	renin	Canis lupus familiaris	45-50
3137594-1	1988	The opioid agonist-antagonist pentazocine (1-30 mg/kg) and the partial agonist buprenorphine (0.05-0.25 mg/kg) were tested, alone or in combination with the histamine H1-receptor antagonist tripelennamine (1, 2.5, 5 or 10 mg/kg), on locomotor activity in mice of the CD-1 strain.	Tripelennamine	190-204	histamine receptor H1	Mus musculus	157-178
3539625-3	1986	Pretreatment with tripelennamine (histamine H1-receptor antagonist, 40 mg/kg i.p.)	Tripelennamine	18-32	histamine receptor H 1	Rattus norvegicus	34-55
3522250-3	1986	Moreover, tripelennamine alone increased renin secretion.	Tripelennamine	10-24	renin	Canis lupus familiaris	41-46
3888640-4	1985	Pretreatment with a dose of more than 20 mg/kg of histamine H1-receptor antagonists such as tripelennamine or diphenhydramine prior to the injection of compound 48/80 (3.0 mg/kg s.c.) attenuated or abolished the effects of compound 48/80 on PRA, hematocrit and plasma extravasation.	Tripelennamine	92-106	histamine receptor H 1	Rattus norvegicus	50-71
3918121-0	1985	Outbreak of endocarditis caused by Pseudomonas aeruginosa serotype O11 among pentazocine and tripelennamine abusers in Chicago.	Tripelennamine	93-107	immunoglobulin kappa variable 2-40	Homo sapiens	67-70
6759742-3	1982	Since the histamine-induced contraction was inhibited by tripelennamine, the contraction seems to be mediated by histamine H1-receptor.	Tripelennamine	57-71	histamine receptor H 1	Rattus norvegicus	113-134
996853-3	1976	The positive responses to histamine were not suppressed by treatment with propranolol in doses which blocked responses to norepinephrine, but these were significantly suppressed by a histamine H1 receptor blocking agent, tripelennamine.	Tripelennamine	221-235	histamine receptor H1	Canis lupus familiaris	183-204
20992876-0	1946	Pyribenzamine (n"-pyridyl-n"-benzyl-n-dimethylethylenediamine HC1), an antagonist of histamine.	Tripelennamine	0-13	CYCS pseudogene 39	Homo sapiens	62-65