PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27081184-6	2016	Under the action of PENETRATION2 (PEN2), an atypical myrosinase, and PEN3, an ATP binding cassette transporter, 4MI3G is converted to extracellular unstable antimicrobial compounds, possibly isothiocyanates that can react with nucleophiles and release the stable thiocyanate ion.	Isothiocyanates	191-206	Glycosyl hydrolase superfamily protein	Arabidopsis thaliana	20-32
27081184-6	2016	Under the action of PENETRATION2 (PEN2), an atypical myrosinase, and PEN3, an ATP binding cassette transporter, 4MI3G is converted to extracellular unstable antimicrobial compounds, possibly isothiocyanates that can react with nucleophiles and release the stable thiocyanate ion.	Isothiocyanates	191-206	Glycosyl hydrolase superfamily protein	Arabidopsis thaliana	34-38
27081184-6	2016	Under the action of PENETRATION2 (PEN2), an atypical myrosinase, and PEN3, an ATP binding cassette transporter, 4MI3G is converted to extracellular unstable antimicrobial compounds, possibly isothiocyanates that can react with nucleophiles and release the stable thiocyanate ion.	Isothiocyanates	191-206	putative pentacyclic triterpene synthase 3	Arabidopsis thaliana	69-73
26397194-0	2015	Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression.	Isothiocyanates	0-15	protein tyrosine kinase 2	Homo sapiens	82-85
26542215-5	2015	These isothiocyanates increased Mcl-1 ubiquitination and either isothiocyanate treatment, or RNAi-mediated silencing of USP9x decreased Mcl-1 levels, consistent with the notion that USP9x is a primary target of isothiocyanate activity.	Isothiocyanates	6-21	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	32-37
26014809-0	2016	Sensitization of estrogen receptor-positive breast cancer cell lines to 4-hydroxytamoxifen by isothiocyanates present in cruciferous plants.	Isothiocyanates	94-109	estrogen receptor 1	Homo sapiens	17-34
26542215-5	2015	These isothiocyanates increased Mcl-1 ubiquitination and either isothiocyanate treatment, or RNAi-mediated silencing of USP9x decreased Mcl-1 levels, consistent with the notion that USP9x is a primary target of isothiocyanate activity.	Isothiocyanates	6-21	ubiquitin specific peptidase 9 X-linked	Homo sapiens	182-187
26542215-6	2015	These isothiocyanates also increased ubiquitination of the oncogenic fusion protein Bcr-Abl, resulting in degradation under low isothiocyanate concentrations and aggregation under high isothiocyanate concentrations.	Isothiocyanates	6-21	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	84-91
26397194-0	2015	Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression.	Isothiocyanates	0-15	mitogen-activated protein kinase 8	Homo sapiens	86-89
26397194-0	2015	Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression.	Isothiocyanates	0-15	matrix metallopeptidase 9	Homo sapiens	99-104
25712054-0	2015	CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells.	Isothiocyanates	52-67	chemokine (C-X-C motif) receptor 4	Mus musculus	0-5
25800511-7	2015	These results indicate that isothiocyanates/indoles and protocatechuic and tannic acids induce phase II and antioxidant gene expression in HepG2 cells through the Nrf2-Keap1-ARE signaling pathway.	Isothiocyanates	28-43	NFE2 like bZIP transcription factor 2	Homo sapiens	163-167
25800511-7	2015	These results indicate that isothiocyanates/indoles and protocatechuic and tannic acids induce phase II and antioxidant gene expression in HepG2 cells through the Nrf2-Keap1-ARE signaling pathway.	Isothiocyanates	28-43	kelch like ECH associated protein 1	Homo sapiens	168-173
26094214-1	2015	Dietary isothiocyanates are potent inducers of the NF-E2-related factor 2 (Nrf2) pathway.	Isothiocyanates	8-23	NFE2 like bZIP transcription factor 2	Homo sapiens	51-73
26094214-1	2015	Dietary isothiocyanates are potent inducers of the NF-E2-related factor 2 (Nrf2) pathway.	Isothiocyanates	8-23	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79
25851421-1	2015	SCOPE: Cruciferous-rich diets have been associated with reduction in plasma LDL-cholesterol (LDL-C), which may be due to the action of isothiocyanates derived from glucosinolates that accumulate in these vegetables.	Isothiocyanates	135-150	component of oligomeric golgi complex 2	Homo sapiens	76-91
25851421-1	2015	SCOPE: Cruciferous-rich diets have been associated with reduction in plasma LDL-cholesterol (LDL-C), which may be due to the action of isothiocyanates derived from glucosinolates that accumulate in these vegetables.	Isothiocyanates	135-150	component of oligomeric golgi complex 2	Homo sapiens	93-98
25672622-3	2015	Health-promoting nutrients and other factors act, at least in part by raising Nrf2 including: many phenolic antioxidants; gamma- and delta-tocopherols and tocotrienols; long chain omega-3 fatty acids DHA and EPA; many carotenoids of which lycopene may be the most active; isothiocyanates from cruciferous vegetables; sulfur compounds from allium vegetables; terpenoids.	Isothiocyanates	272-287	NFE2 like bZIP transcription factor 2	Homo sapiens	78-82
25743213-0	2015	Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor.	Isothiocyanates	26-41	macrophage migration inhibitory factor	Homo sapiens	55-93
25743213-4	2015	Isothiocyanates inhibit MIF tautomerase activity via covalent modification of the N-terminal proline.	Isothiocyanates	0-15	macrophage migration inhibitory factor	Homo sapiens	24-27
25593219-1	2015	Sulforaphane (SFN), one of the most important isothiocyanates in the human diet, is known to have chemo-preventive and antioxidant activities in different tissues via activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 and NAD(P)H quinone oxidoreductase 1.	Isothiocyanates	46-61	NFE2 like bZIP transcription factor 2	Homo sapiens	181-224
24912716-3	2014	Enzymatic hydrolysis of glucosinolates by endogenous myrosinase (MYR) can form isothiocyanates with health-promoting activities.	Isothiocyanates	79-94	myrosinase	Brassica oleracea	53-63
26134366-0	2015	Sensitization of HER2 Positive Breast Cancer Cells to Lapatinib Using Plants-Derived Isothiocyanates.	Isothiocyanates	85-100	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-21
25108507-11	2014	The results of this study on apoptosis-related factors might help to develop novel protective and therapeutic approaches, such as isoflavonoids and isothiocyanates, which were associated with decreased Bcl-2/Bax ratio, against the malignant epithelial ovarian tumors.	Isothiocyanates	148-163	BCL2 apoptosis regulator	Homo sapiens	202-207
25165394-2	2014	Glutathione S-transferase (GST) M1 and GSTT1 metabolize isothiocyanates; genetic variants may result in differences in biologic response.	Isothiocyanates	56-71	glutathione S-transferase mu 1	Homo sapiens	0-34
25165394-2	2014	Glutathione S-transferase (GST) M1 and GSTT1 metabolize isothiocyanates; genetic variants may result in differences in biologic response.	Isothiocyanates	56-71	glutathione S-transferase theta 1	Homo sapiens	39-44
25329882-0	2014	Overexpression of glutathione transferase E7 in Drosophila differentially impacts toxicity of organic isothiocyanates in males and females.	Isothiocyanates	102-117	Glutathione S transferase E7	Drosophila melanogaster	18-44
25108507-11	2014	The results of this study on apoptosis-related factors might help to develop novel protective and therapeutic approaches, such as isoflavonoids and isothiocyanates, which were associated with decreased Bcl-2/Bax ratio, against the malignant epithelial ovarian tumors.	Isothiocyanates	148-163	BCL2 associated X, apoptosis regulator	Homo sapiens	208-211
23836589-0	2013	Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFkappaB activation.	Isothiocyanates	0-15	NFE2 like bZIP transcription factor 2	Homo sapiens	93-97
25013352-3	2014	Many studies have examined the effects of specific COX-2 and 5-LOX inhibitors on human colorectal cancer, but the role of isothiocyanates (ITSCs) as COX-LOX dual inhibitors engaged in hyaluronan-CD44 interaction has not been studied.	Isothiocyanates	122-137	CD44 molecule (Indian blood group)	Homo sapiens	195-199
24434421-3	2014	Inhibitors of the pro-survival pathways ERK, MAPK and PI3K almost completely abolished the increase in HO-1 induction and heme oxygenase activity, while the JNK pathway appeared to be mainly involved in the apoptosis triggered by the isothiocyanates.	Isothiocyanates	234-249	heme oxygenase 1	Rattus norvegicus	103-107
24434421-3	2014	Inhibitors of the pro-survival pathways ERK, MAPK and PI3K almost completely abolished the increase in HO-1 induction and heme oxygenase activity, while the JNK pathway appeared to be mainly involved in the apoptosis triggered by the isothiocyanates.	Isothiocyanates	234-249	mitogen-activated protein kinase 8	Rattus norvegicus	157-160
24434421-9	2014	These findings indicate that water-soluble isothiocyanates counteract renal dysfunction and apoptosis by up-regulating the HO-1 system and could be used as a supplementary treatment to mitigate CDDP-induced nephrotoxic effects.	Isothiocyanates	43-58	heme oxygenase 1	Rattus norvegicus	123-127
24533814-3	2014	However, most known inducers (e.g., triterpenoids, isothiocyanates and sulfoxythiocarbamates) that activate the ARE system through electrophilic attacks on the cysteine sulfhydryl group of Keap1 also disrupt theKeap1-Nrf2 interaction.	Isothiocyanates	51-66	kelch like ECH associated protein 1	Homo sapiens	189-194
24533814-3	2014	However, most known inducers (e.g., triterpenoids, isothiocyanates and sulfoxythiocarbamates) that activate the ARE system through electrophilic attacks on the cysteine sulfhydryl group of Keap1 also disrupt theKeap1-Nrf2 interaction.	Isothiocyanates	51-66	NFE2 like bZIP transcription factor 2	Homo sapiens	217-221
24129618-0	2013	AlCl3-promoted [3 + 2] annulation of cis-2,3-disubstituted cyclopropane 1,1-diesters with isothiocyanates: stereoselective synthesis of densely substituted 2-iminodihydrothiophenes.	Isothiocyanates	90-105	suppressor of cytokine signaling 2	Homo sapiens	37-42
24129618-1	2013	cis-2,3-Disubstituted cyclopropane 1,1-diesters were found to be much more reactive than their corresponding trans-isomers in the AlCl3-promoted [3 + 2]-annulations with isothiocyanates.	Isothiocyanates	170-185	suppressor of cytokine signaling 2	Homo sapiens	0-5
23836589-0	2013	Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFkappaB activation.	Isothiocyanates	0-15	nuclear factor kappa B subunit 1	Homo sapiens	138-146
25238152-2	2014	In this study, we tested whether two distinct bitter taste receptors, the bitter taste receptor 138 (T2R138), selectively activated by isothiocyanates, and the broadly tuned bitter taste receptor 108 (T2R108) are regulated by luminal content.	Isothiocyanates	135-150	taste receptor, type 2, member 138	Mus musculus	101-107
24083611-5	2014	According to their structural features, CYP1 inhibitors are divided into the following categories: flavonoids, trans-stilbenes, coumarins, terpenoids, alkaloids, quinones, isothiocyanates and synthetic aromatics.	Isothiocyanates	172-187	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	40-44
23770684-0	2013	HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.	Isothiocyanates	138-153	RB binding protein 8, endonuclease	Homo sapiens	15-19
22923034-6	2013	Only transient changes in DNMT mRNA expression, which occurred mostly in the treatment groups containing isothiocyanates, were observed, and these occurred only for specific DNMT transcripts and did not lead to the modification of the aberrant methylation status present in these cells.	Isothiocyanates	105-120	DNA methyltransferase 1	Homo sapiens	26-30
24454992-3	2013	In vitro and in vivo studies suggest a chemopreventive activity of isothiocyanates through the redox-sensitive transcription factor Nrf2.	Isothiocyanates	67-82	NFE2 like bZIP transcription factor 2	Homo sapiens	132-136
23477345-1	2013	Readily available 1-mesyl-1,2,3-triazoles are efficiently converted into a variety of imidazolones and thiazoles by Rh(II)-catalyzed denitrogenative reactions with isocyanates and isothiocyanates, respectively.	Isothiocyanates	180-195	Rh blood group D antigen	Homo sapiens	116-121
23403058-0	2013	Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin.	Isothiocyanates	44-59	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
23649257-0	2013	Glucosinolate degradation products, isothiocyanates, nitriles, and thiocyanates, induce stomatal closure accompanied by peroxidase-mediated reactive oxygen species production in Arabidopsis thaliana.	Isothiocyanates	36-51	peroxidase	Arabidopsis thaliana	120-130
23781297-0	2013	Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates.	Isothiocyanates	141-156	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
23781297-0	2013	Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates.	Isothiocyanates	141-156	kelch like ECH associated protein 1	Homo sapiens	19-24
23781297-3	2013	Natural ITCs are key chemopreventive ingredients of cruciferous vegetables, and one of the prime chemopreventive mechanisms of natural isothiocyanates is the induction of Nrf2/ARE-dependent gene expression that plays a critical role in cellular defense against electrophiles and reactive oxygen species.	Isothiocyanates	135-150	NFE2 like bZIP transcription factor 2	Homo sapiens	171-175
22869685-7	2012	These results indicate the following: 1) 6-MSITC and 6-MTITC activate both mTRPA1 and hTRPA1; 2) 6-MSITC activates mTRPV1; and 3) the pharmacological functions of these isothiocyanates could be derived from TRPA1 activation.	Isothiocyanates	169-184	transient receptor potential cation channel subfamily A member 1	Homo sapiens	86-92
22869685-0	2012	Isothiocyanates from Wasabia japonica activate transient receptor potential ankyrin 1 channel.	Isothiocyanates	0-15	transient receptor potential cation channel subfamily A member 1	Homo sapiens	47-85
22869685-7	2012	These results indicate the following: 1) 6-MSITC and 6-MTITC activate both mTRPA1 and hTRPA1; 2) 6-MSITC activates mTRPV1; and 3) the pharmacological functions of these isothiocyanates could be derived from TRPA1 activation.	Isothiocyanates	169-184	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	115-121
22869685-7	2012	These results indicate the following: 1) 6-MSITC and 6-MTITC activate both mTRPA1 and hTRPA1; 2) 6-MSITC activates mTRPV1; and 3) the pharmacological functions of these isothiocyanates could be derived from TRPA1 activation.	Isothiocyanates	169-184	transient receptor potential cation channel subfamily A member 1	Homo sapiens	76-81
22643862-2	2012	It is demonstrated in this paper that the isothiocyanates R,S-sulforaphane and erucin are non-competitive antagonists of the aryl hydrocarbon (Ah) receptor.	Isothiocyanates	42-57	aryl hydrocarbon receptor	Rattus norvegicus	125-155
22869685-6	2012	These isothiocyanates also activated endogenous TRPA1 expressed in mouse dorsal root ganglion neurons and intraplantar injection of 10-30 mM 6-MSITC-evoked pain-related behaviors in mice.	Isothiocyanates	6-21	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	48-53
22643862-4	2012	In contrast, the classical Ah receptor agonist benzo[a]pyrene was a potent inducer of CYP1A1 mRNA levels, with this effect being effectively antagonized by the two isothiocyanates.	Isothiocyanates	164-179	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	86-92
22643862-3	2012	Both isothiocyanates were poor agonists for the receptor and elevated CYP1A1 mRNA levels only modestly when incubated with precision-cut rat liver slices.	Isothiocyanates	5-20	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	70-76
22643862-4	2012	In contrast, the classical Ah receptor agonist benzo[a]pyrene was a potent inducer of CYP1A1 mRNA levels, with this effect being effectively antagonized by the two isothiocyanates.	Isothiocyanates	164-179	aryl hydrocarbon receptor	Rattus norvegicus	27-38
22527941-1	2012	Isothiocyanates, among which alyssin is counted, are the compounds that have proved chemopreventive properties and the ability to induce the 2 and the 3 detoxification phase by affecting the transcription factor nuclear erythroid 2-related factor (Nrf2).	Isothiocyanates	0-15	NFE2 like bZIP transcription factor 2	Homo sapiens	248-252
22931430-0	2012	Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates.	Isothiocyanates	129-144	macrophage migration inhibitory factor	Homo sapiens	48-86
22931430-5	2012	We report the crystallographic structures of human MIF bound to phenethylisothiocyanate and to l-sulforaphane (dietary isothiocyanates derived from watercress and broccoli, respectively) and correlate structural features of these two isothiocyanates with their second-order rate constants for MIF inactivation.	Isothiocyanates	119-134	macrophage migration inhibitory factor	Homo sapiens	51-54
22931430-5	2012	We report the crystallographic structures of human MIF bound to phenethylisothiocyanate and to l-sulforaphane (dietary isothiocyanates derived from watercress and broccoli, respectively) and correlate structural features of these two isothiocyanates with their second-order rate constants for MIF inactivation.	Isothiocyanates	234-249	macrophage migration inhibitory factor	Homo sapiens	51-54
22664424-0	2012	Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes.	Isothiocyanates	24-39	NFE2 like bZIP transcription factor 2	Rattus norvegicus	110-114
22820176-0	2012	TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death.	Isothiocyanates	39-54	thioredoxin reductase 1	Homo sapiens	0-5
22820176-0	2012	TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death.	Isothiocyanates	39-54	glutathione peroxidase 2	Homo sapiens	10-14
21602309-2	2011	Isothiocyanates, such as sulforaphane from broccoli, are very potent inactivators of MIF tautomerase activity.	Isothiocyanates	0-15	macrophage migration inhibitory factor	Homo sapiens	85-88
22178957-3	2012	The nuclear factor-erythroid-2-related factor 2 system, which orchestrates the expression of a wide array of antioxidant genes, plays a role in the protective effect of isothiocyanates against almost all the pathological conditions reported above.	Isothiocyanates	169-184	NFE2 like bZIP transcription factor 2	Homo sapiens	4-47
22178957-5	2012	Chronic inflammation plays a central role in many human diseases and isothiocyanates inhibit the activity of many inflammation components, suppress cyclooxygenase 2, and irreversibly inactivate the macrophage migration inhibitory factor.	Isothiocyanates	69-84	prostaglandin-endoperoxide synthase 2	Homo sapiens	148-164
22178957-5	2012	Chronic inflammation plays a central role in many human diseases and isothiocyanates inhibit the activity of many inflammation components, suppress cyclooxygenase 2, and irreversibly inactivate the macrophage migration inhibitory factor.	Isothiocyanates	69-84	macrophage migration inhibitory factor	Homo sapiens	198-236
22228407-1	2012	Epithiospecifier protein (ESP) is responsible for diverting glucosinolate hydrolysis from the generation of isothiocyanates to that of epithionitriles or nitriles, and thereby negatively affects the ability of the plant to defend itself against certain insects.	Isothiocyanates	108-123	epithiospecifier protein	Arabidopsis thaliana	26-29
22131196-1	2012	In this study, we tested the ability of structure-related isothiocyanates to induce the antiatherogenic enzyme paraoxonase-1 (PON1) in cultured hepatocytes.	Isothiocyanates	58-73	paraoxonase 1	Mus musculus	111-124
22131196-1	2012	In this study, we tested the ability of structure-related isothiocyanates to induce the antiatherogenic enzyme paraoxonase-1 (PON1) in cultured hepatocytes.	Isothiocyanates	58-73	paraoxonase 1	Mus musculus	126-130
21778185-2	2011	The "mustard oil bomb" which includes myrosinase and glucosinolates is triggered by abiotic and biotic stress, resulting in the formation of toxic products such as nitriles and isothiocyanates.	Isothiocyanates	177-192	myrosinase	Brassica napus	38-48
21132492-5	2011	It may be inferred that the ability of isothiocyanates to enhance hepatic microsomal epoxide hydrolase and glucuronosyl transferase activities is dependent on the nature of the side chain.	Isothiocyanates	39-54	epoxide hydrolase 1	Rattus norvegicus	74-102
22377900-7	2012	Isothiocyanates, sulfur-containing phytochemicals present in cruciferous plants, are well known to target Keap1 for activating the transcription factor Nrf2 for inducing self-defensive and anti-oxidative gene expression.	Isothiocyanates	0-15	kelch like ECH associated protein 1	Homo sapiens	106-111
22377900-7	2012	Isothiocyanates, sulfur-containing phytochemicals present in cruciferous plants, are well known to target Keap1 for activating the transcription factor Nrf2 for inducing self-defensive and anti-oxidative gene expression.	Isothiocyanates	0-15	NFE2 like bZIP transcription factor 2	Homo sapiens	152-156
21465338-1	2012	Brassica vegetables are attracting a great deal of attention as healthy foods because of the fact that they contain substantial amounts of secondary metabolite glucosinolates that are converted into isothiocyanates, such as sulforaphane [(-)1-isothiocyanato-4R-(methylsulfinyl)-butane] (R-SFN), through the actions of chopping or chewing the vegetables.	Isothiocyanates	199-214	RNA exonuclease 2	Homo sapiens	289-292
21382770-0	2011	Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury.	Isothiocyanates	0-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	51-55
21382770-3	2011	OBJECTIVES: We investigated the protective effect of isothiocyanates, which are known to activate Nrf2, on the accumulation of mercury after exposure to MeHg in vitro and in vivo.	Isothiocyanates	53-68	nuclear factor, erythroid derived 2, like 2	Mus musculus	98-102
21382770-6	2011	RESULTS: The isothiocyanates 6-methylsulfinylhexyl isothiocyanate (6-HITC) and sulforaphane (SFN) activated Nrf2 and up-regulated downstream proteins associated with MeHg excretion, such as glutamate-cysteine ligase, glutathione S-transferase, and multidrug resistance-associated protein, in primary mouse hepatocytes.	Isothiocyanates	13-28	nuclear factor, erythroid derived 2, like 2	Mus musculus	108-112
21382770-6	2011	RESULTS: The isothiocyanates 6-methylsulfinylhexyl isothiocyanate (6-HITC) and sulforaphane (SFN) activated Nrf2 and up-regulated downstream proteins associated with MeHg excretion, such as glutamate-cysteine ligase, glutathione S-transferase, and multidrug resistance-associated protein, in primary mouse hepatocytes.	Isothiocyanates	13-28	hematopoietic prostaglandin D synthase	Mus musculus	217-287
21712538-8	2011	Isothiocyanates induced apoptotic death of myeloma cells; depletion of mitochondrial membrane potential; cleavage of PARP and caspases-3 and -9; as well as down-regulation of anti-apoptotic proteins including Mcl-1, X-IAP, c-IAP and survivin.	Isothiocyanates	0-15	collagen type XI alpha 2 chain	Homo sapiens	117-143
21712538-8	2011	Isothiocyanates induced apoptotic death of myeloma cells; depletion of mitochondrial membrane potential; cleavage of PARP and caspases-3 and -9; as well as down-regulation of anti-apoptotic proteins including Mcl-1, X-IAP, c-IAP and survivin.	Isothiocyanates	0-15	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	209-214
21712538-8	2011	Isothiocyanates induced apoptotic death of myeloma cells; depletion of mitochondrial membrane potential; cleavage of PARP and caspases-3 and -9; as well as down-regulation of anti-apoptotic proteins including Mcl-1, X-IAP, c-IAP and survivin.	Isothiocyanates	0-15	X-linked inhibitor of apoptosis	Homo sapiens	216-221
21602309-6	2011	RESULTS: A structure-potency study of MIF tautomerase inactivation by isothiocyanates showed that sulforaphane, benzyl, n-hexyl, and phenethyl isothiocyanates were especially potent.	Isothiocyanates	70-85	macrophage migration inhibitory factor	Homo sapiens	38-41
20608730-12	2010	It was concluded that manipulation of endogenous iron levels of ESP-containing plants could increase the conversion of glucosinolates to isothiocyanates and enhance potential health benefits.	Isothiocyanates	137-152	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	64-67
21656528-2	2011	The aim of this study was to examine the potential activation and synergism of Nrf2-ARE-mediated transcriptional activity between four common phytochemicals present in cruciferous vegetables; the indoles: indole-3-carbinol (I3C), 3,3"-diindolylmethane (DIM); and the isothiocyanates (ITCs): phenethyl isothiocyanate (PEITC) and sulforaphane (SFN).	Isothiocyanates	267-282	NFE2 like bZIP transcription factor 2	Homo sapiens	79-83
21656528-2	2011	The aim of this study was to examine the potential activation and synergism of Nrf2-ARE-mediated transcriptional activity between four common phytochemicals present in cruciferous vegetables; the indoles: indole-3-carbinol (I3C), 3,3"-diindolylmethane (DIM); and the isothiocyanates (ITCs): phenethyl isothiocyanate (PEITC) and sulforaphane (SFN).	Isothiocyanates	284-288	NFE2 like bZIP transcription factor 2	Homo sapiens	79-83
21298592-1	2011	The principal objectives of this study were to evaluate whether exposure of rats to low doses of isothiocyanates modulates the overall metabolism of heterocyclic amine 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ), as exemplified by urinary mutagenicity, a food carcinogen, and to relate any modifications in metabolism to changes in CYP1 and glutathione S-transferase activities.	Isothiocyanates	97-112	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	334-338
21298592-1	2011	The principal objectives of this study were to evaluate whether exposure of rats to low doses of isothiocyanates modulates the overall metabolism of heterocyclic amine 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ), as exemplified by urinary mutagenicity, a food carcinogen, and to relate any modifications in metabolism to changes in CYP1 and glutathione S-transferase activities.	Isothiocyanates	97-112	hematopoietic prostaglandin D synthase	Rattus norvegicus	343-368
21112285-1	2010	The transient receptor potential A1 channel (TRPA1) is activated by various compounds, including isothiocyanates, menthol, and cinnamaldehyde.	Isothiocyanates	97-112	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	45-50
20633589-5	2010	Receptors known as TRPA1 ion channels present in trigeminal and associated peripheral afferent nerves have shown particular sensitivity to isothiocyanates.	Isothiocyanates	139-154	transient receptor potential cation channel subfamily A member 1	Homo sapiens	19-24
20638746-4	2011	Both glucosinolates, at concentrations as low as 1 muM, up-regulated the O-deethylation of ethoxyresorufin and the apoprotein levels of CYP1A1 and CYP1B1; supplementation of the incubation medium with myrosinase, the enzyme that converts glucosinolates to their corresponding isothiocyanates, abolished the rise in ethoxyresorufin O-deethylase activity.	Isothiocyanates	276-291	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	136-142
21241062-0	2011	Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.	Isothiocyanates	60-75	tumor protein p53	Homo sapiens	30-33
20368435-7	2010	Our results show that compounds containing alpha-beta unsaturated carbonyls, sulfhydryl reactive metals, and isothiocyanates are strong activators of Nrf2 in a reporter assay system and in primary human CLL based on increased expression of the Nrf2 target heme oxygenase-1.	Isothiocyanates	109-124	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
20031254-0	2010	Exogenously applied isothiocyanates enhance glutathione S-transferase expression in Arabidopsis but act as herbicides at higher concentrations.	Isothiocyanates	20-35	glutathione S-transferase tau 5	Arabidopsis thaliana	44-69
20368435-7	2010	Our results show that compounds containing alpha-beta unsaturated carbonyls, sulfhydryl reactive metals, and isothiocyanates are strong activators of Nrf2 in a reporter assay system and in primary human CLL based on increased expression of the Nrf2 target heme oxygenase-1.	Isothiocyanates	109-124	NFE2 like bZIP transcription factor 2	Homo sapiens	244-248
20368435-7	2010	Our results show that compounds containing alpha-beta unsaturated carbonyls, sulfhydryl reactive metals, and isothiocyanates are strong activators of Nrf2 in a reporter assay system and in primary human CLL based on increased expression of the Nrf2 target heme oxygenase-1.	Isothiocyanates	109-124	heme oxygenase 1	Homo sapiens	256-272
20042523-2	2010	Glutathione S-transferases (GSTs) are involved in the metabolism and elimination of isothiocyanates; thus, genetic variations in these enzymes may affect in vivo bioavailability and the activity of isothiocyanates.	Isothiocyanates	84-99	glutathione S-transferase kappa 1	Homo sapiens	28-32
20042523-6	2010	The strongest inverse association was found among individuals with both the GSTM1-null and the GSTT1-null genotypes, with an adjusted odds ratio of 0.51 (95% CI: 0.27, 0.95), in a comparison of the highest with the lowest tertile of urinary isothiocyanates.	Isothiocyanates	241-256	glutathione S-transferase mu 1	Homo sapiens	76-81
20042523-2	2010	Glutathione S-transferases (GSTs) are involved in the metabolism and elimination of isothiocyanates; thus, genetic variations in these enzymes may affect in vivo bioavailability and the activity of isothiocyanates.	Isothiocyanates	198-213	glutathione S-transferase kappa 1	Homo sapiens	28-32
20042523-6	2010	The strongest inverse association was found among individuals with both the GSTM1-null and the GSTT1-null genotypes, with an adjusted odds ratio of 0.51 (95% CI: 0.27, 0.95), in a comparison of the highest with the lowest tertile of urinary isothiocyanates.	Isothiocyanates	241-256	glutathione S-transferase theta 1	Homo sapiens	95-100
19362136-0	2009	The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells.	Isothiocyanates	14-29	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	33-39
19776019-0	2009	Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates.	Isothiocyanates	102-117	macrophage migration inhibitory factor	Homo sapiens	63-90
19776019-10	2009	The isothiocyanates have significant potential for development as MIF inhibitors, and this activity may contribute to the biological properties of these phytochemicals.	Isothiocyanates	4-19	macrophage migration inhibitory factor	Homo sapiens	66-69
19362136-0	2009	The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells.	Isothiocyanates	14-29	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	44-50
19291240-8	2009	CONCLUSIONS: Glucosinolate hydrolysis products and specifically the isothiocyanates SFN and BITC have significant antimicrobial activity against Gram-positive and Gram-negative bacteria, and might be useful in controlling human pathogens through the diet.	Isothiocyanates	68-83	RNA exonuclease 2	Homo sapiens	84-87
19536870-4	2009	Both isothiocyanates elevated NQO1 activity in rat slices that was paralleled by a fourfold rise in protein levels.	Isothiocyanates	5-20	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	30-34
19328833-5	2009	PARP-1 cleavage occurs only after exposure to high concentrations of ER (50 microM), in accordance to previous studies showing similar bioactivity of other isothiocyanates (ITCs).	Isothiocyanates	156-171	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
19328833-5	2009	PARP-1 cleavage occurs only after exposure to high concentrations of ER (50 microM), in accordance to previous studies showing similar bioactivity of other isothiocyanates (ITCs).	Isothiocyanates	173-177	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
19124514-8	2009	There was a weak suggestion that for individuals with the GSTP1 AG or GG genotype, a detectable amount of isothiocyanates further decreases one"s risk of colorectal cancer compared with those with the GSTP1 AA genotype, but the interaction term was not statistically significant (P = 0.09).	Isothiocyanates	106-121	glutathione S-transferase pi 1	Homo sapiens	58-63
19159619-0	2009	Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling.	Isothiocyanates	61-76	nuclear factor kappa B subunit 1	Homo sapiens	5-14
19336732-1	2009	Chemoprevention by isothiocyanates from cruciferous vegetables occurs partly through up-regulation of phase II conjugating enzymes, such as UDP-glucuronosyltransferases (UGT).	Isothiocyanates	19-34	beta-1,3-glucuronyltransferase 2	Homo sapiens	140-168
19336732-1	2009	Chemoprevention by isothiocyanates from cruciferous vegetables occurs partly through up-regulation of phase II conjugating enzymes, such as UDP-glucuronosyltransferases (UGT).	Isothiocyanates	19-34	beta-1,3-glucuronyltransferase 2	Homo sapiens	170-173
19202560-7	2009	Also a mechanistic study was performed including isothiocyanates" influence on CYP1A1 and CYP1A2 catalytic activity, enzymatic protein level, and AhR translocation.	Isothiocyanates	49-64	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	79-85
19202560-7	2009	Also a mechanistic study was performed including isothiocyanates" influence on CYP1A1 and CYP1A2 catalytic activity, enzymatic protein level, and AhR translocation.	Isothiocyanates	49-64	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	90-96
19202560-10	2009	In general, CYP1A2 was altered in the more meaningful way than CYP1A1 by isothiocyanates.	Isothiocyanates	73-88	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	12-18
19202560-10	2009	In general, CYP1A2 was altered in the more meaningful way than CYP1A1 by isothiocyanates.	Isothiocyanates	73-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	63-69
19082460-0	2009	Isothiocyanates repress estrogen receptor alpha expression in breast cancer cells.	Isothiocyanates	0-15	estrogen receptor 1	Homo sapiens	24-47
18639976-1	2008	Isothiocyanates are a class of phytochemicals able to induce apoptosis in numerous cells including Jurkat T-lymphoma cells overexpressing the oncoprotein Bcl-2.	Isothiocyanates	0-15	BCL2 apoptosis regulator	Homo sapiens	154-159
18981181-5	2008	GLUT1 lysine residues were modified by isothiocyanates and N-hydroxysuccinimide (NHS) esters in a substrate-dependent manner.	Isothiocyanates	39-54	solute carrier family 2 member 1	Homo sapiens	0-5
26050183-14	2008	The synergistic effect between isothiocyanates and Se at physiologically-relevant concentrations on the induction of TR1 may play an important role in protection against oxidative stress.	Isothiocyanates	31-46	thioredoxin reductase 1	Homo sapiens	117-120
18773935-7	2008	CYP3A2 apoprotein levels were modestly elevated in rat liver by both isothiocyanates both of which, however, failed to influence CYP3A4 expression in human liver.	Isothiocyanates	69-84	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	0-6
26050183-1	2008	Dietary isothiocyanates and selenium (Se) can up-regulate thioredoxin reductase 1 (TR1) in cultured human HepG2 and MCF-7 cells [Zhang et al.	Isothiocyanates	8-23	thioredoxin reductase 1	Homo sapiens	58-81
18787901-11	2008	Thus, the production of simple nitriles instead of isothiocyanates, as catalyzed by ESP, can promote both direct and indirect defense against the specialist herbivore P. rapae.	Isothiocyanates	51-66	epithiospecifier protein	Arabidopsis thaliana	84-87
17657593-0	2008	Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression.	Isothiocyanates	24-39	heme oxygenase 1	Homo sapiens	91-107
18563540-1	2008	PURPOSE: To compare the ability of alkyl-aryl isothiocyanates (ITCs) to increase the activities of the Phase 2 detoxification enzymes NAD[P]H:quinone acceptor oxidoreductase 1 (NQO1) and glutathione S-transferases (GST) in rat tissues in vivo and in cells in vitro.	Isothiocyanates	63-67	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	177-181
18458837-5	2008	Isothiocyanates appear to alter gene expression through modification of critical thiols in regulatory proteins such as Keap1 (Kelch-like ECH-associated protein 1) or IKK (IkappaB kinase), causing activation of Nrf2 and inactivation of NF-kappaB, respectively.	Isothiocyanates	0-15	kelch like ECH associated protein 1	Homo sapiens	119-124
18458837-5	2008	Isothiocyanates appear to alter gene expression through modification of critical thiols in regulatory proteins such as Keap1 (Kelch-like ECH-associated protein 1) or IKK (IkappaB kinase), causing activation of Nrf2 and inactivation of NF-kappaB, respectively.	Isothiocyanates	0-15	kelch like ECH associated protein 1	Homo sapiens	126-161
18458837-5	2008	Isothiocyanates appear to alter gene expression through modification of critical thiols in regulatory proteins such as Keap1 (Kelch-like ECH-associated protein 1) or IKK (IkappaB kinase), causing activation of Nrf2 and inactivation of NF-kappaB, respectively.	Isothiocyanates	0-15	NFE2 like bZIP transcription factor 2	Homo sapiens	210-214
18458837-5	2008	Isothiocyanates appear to alter gene expression through modification of critical thiols in regulatory proteins such as Keap1 (Kelch-like ECH-associated protein 1) or IKK (IkappaB kinase), causing activation of Nrf2 and inactivation of NF-kappaB, respectively.	Isothiocyanates	0-15	nuclear factor kappa B subunit 1	Homo sapiens	235-244
26050183-1	2008	Dietary isothiocyanates and selenium (Se) can up-regulate thioredoxin reductase 1 (TR1) in cultured human HepG2 and MCF-7 cells [Zhang et al.	Isothiocyanates	8-23	thioredoxin reductase 1	Homo sapiens	83-86
17657593-0	2008	Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression.	Isothiocyanates	24-39	heme oxygenase 1	Homo sapiens	109-113
17657593-3	2008	In this study, the effects of ten structurally related isothiocyanates on the antioxidant response element (ARE)-mediated antioxidant enzyme heme oxygenase-1 (HO-1) induction in human hepatoma HepG2-C8 cells were evaluated.	Isothiocyanates	55-70	heme oxygenase 1	Homo sapiens	141-157
17657593-3	2008	In this study, the effects of ten structurally related isothiocyanates on the antioxidant response element (ARE)-mediated antioxidant enzyme heme oxygenase-1 (HO-1) induction in human hepatoma HepG2-C8 cells were evaluated.	Isothiocyanates	55-70	heme oxygenase 1	Homo sapiens	159-163
17617661-2	2007	Isothiocyanates, thought to be responsible for the chemopreventive properties of this food group, are conjugated to glutathione by glutathione S-transferases (GSTs) before urinary excretion.	Isothiocyanates	0-15	glutathione S-transferase kappa 1	Homo sapiens	159-163
18048326-1	2007	Isothiocyanates and phenolic antioxidants can prevent cancer through activation of Nrf2 (NF-E2 p45-related factor 2), a transcription factor that controls expression of cytoprotective genes through the antioxidant response element (ARE) enhancer.	Isothiocyanates	0-15	NFE2 like bZIP transcription factor 2	Homo sapiens	83-87
18048326-1	2007	Isothiocyanates and phenolic antioxidants can prevent cancer through activation of Nrf2 (NF-E2 p45-related factor 2), a transcription factor that controls expression of cytoprotective genes through the antioxidant response element (ARE) enhancer.	Isothiocyanates	0-15	NFE2 like bZIP transcription factor 2	Homo sapiens	89-115
18326615-1	2008	BACKGROUND: Cruciferous vegetables are the primary source of isothiocyanates and other glucosinolate derivatives that are known to induce phase II detoxifying enzymes, including glutathione S-transferases (GSTs).	Isothiocyanates	61-76	glutathione S-transferase pi 1	Homo sapiens	206-210
17823442-2	2007	Isothiocyanates induce glutathione S-transferases (GSTs), polymorphic genes that code for enzymes that conjugate isothiocyanates, as well as mutagens and reactive oxygen species, to make them more readily excretable.	Isothiocyanates	0-15	glutathione S-transferase mu 1	Homo sapiens	51-55
17823442-2	2007	Isothiocyanates induce glutathione S-transferases (GSTs), polymorphic genes that code for enzymes that conjugate isothiocyanates, as well as mutagens and reactive oxygen species, to make them more readily excretable.	Isothiocyanates	113-128	glutathione S-transferase mu 1	Homo sapiens	51-55
17693660-1	2007	Isothiocyanates are anticarcinogenic phytochemicals found in cruciferous vegetables that both induce and are substrates for the gluthatione S-transferases (GSTs).	Isothiocyanates	0-15	glutathione S-transferase mu 1	Homo sapiens	156-160
17405687-8	2007	GSTs also conjugate isothiocyanates, the chemopreventive compounds found in cruciferous vegetables.	Isothiocyanates	20-35	glutathione S-transferase kappa 1	Homo sapiens	0-4
17484723-7	2007	GSTs from the thermophile Thermosynechococcus elongatus BP-1 and from Synechococcus elongatus PCC 6301 were found to catalyse the conjugation of naturally occurring plant-derived isothiocyanates to glutathione at high rates.	Isothiocyanates	179-194	glutathione S-transferase kappa 1	Homo sapiens	0-4
16928811-0	2006	Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.	Isothiocyanates	23-38	mitogen-activated protein kinase 1	Homo sapiens	110-113
17061170-4	2006	One of these encodes the epithio-specifier protein (ESP) that promotes the formation of nitriles at the expense of isothiocyanates in certain ecotypes of A. thaliana.	Isothiocyanates	115-130	epithiospecifier protein	Arabidopsis thaliana	25-50
17061170-4	2006	One of these encodes the epithio-specifier protein (ESP) that promotes the formation of nitriles at the expense of isothiocyanates in certain ecotypes of A. thaliana.	Isothiocyanates	115-130	epithiospecifier protein	Arabidopsis thaliana	52-55
16704988-4	2006	Although we previously demonstrated that the AR expression could be modulated by isothiocyanates, which are natural constituents of cruciferous vegetables, the mechanism, however, remained to be clarified.	Isothiocyanates	81-96	androgen receptor	Homo sapiens	45-47
16652374-1	2006	Cruciferous vegetable-derived isothiocyanates (ITCs) display potent cancer chemopreventive activity, but also markedly stimulate oncogenic activator protein 1 (AP-1).	Isothiocyanates	30-45	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	160-164
16928811-0	2006	Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.	Isothiocyanates	23-38	mitogen-activated protein kinase 8	Homo sapiens	118-121
16928811-0	2006	Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.	Isothiocyanates	23-38	NFE2 like bZIP transcription factor 2	Homo sapiens	175-179
16506816-0	2006	Effect of isothiocyanates on nuclear accumulation of NF-kappaB, Nrf2, and thioredoxin in caco-2 cells.	Isothiocyanates	10-25	nuclear factor kappa B subunit 1	Homo sapiens	53-62
16596246-2	2006	We have demonstrated that isothiocyanates are also growth regulators, inhibiting cell cycle cdk activity and up-regulating inhibitor p21WAF1 (p21) in cancer cells.	Isothiocyanates	26-41	cyclin dependent kinase inhibitor 1A	Homo sapiens	133-140
16596246-2	2006	We have demonstrated that isothiocyanates are also growth regulators, inhibiting cell cycle cdk activity and up-regulating inhibitor p21WAF1 (p21) in cancer cells.	Isothiocyanates	26-41	cyclin dependent kinase inhibitor 1A	Homo sapiens	133-136
16506816-0	2006	Effect of isothiocyanates on nuclear accumulation of NF-kappaB, Nrf2, and thioredoxin in caco-2 cells.	Isothiocyanates	10-25	thioredoxin	Homo sapiens	74-85
16506816-5	2006	These results show that different individual isothiocyanates may possess some different activities in nuclear accumulation of thioredoxin, NF-kappaB, Nrf2, and production of ROS.	Isothiocyanates	45-60	thioredoxin	Homo sapiens	126-137
16506816-5	2006	These results show that different individual isothiocyanates may possess some different activities in nuclear accumulation of thioredoxin, NF-kappaB, Nrf2, and production of ROS.	Isothiocyanates	45-60	nuclear factor kappa B subunit 1	Homo sapiens	139-148
16506816-1	2006	Early effects (only 1 h of exposure) of three isothiocyanates (benzyl, phenylethyl, and sulforaphane) on nuclear accumulation of thioredoxin, APE/Ref-1, and transcription factors NF-kappaB and Nrf2, as well as production of reactive oxygen species (ROS) and reduced glutathione levels were examined in human adenocarcinoma Caco-2 cells.	Isothiocyanates	46-61	thioredoxin	Homo sapiens	129-140
16506816-5	2006	These results show that different individual isothiocyanates may possess some different activities in nuclear accumulation of thioredoxin, NF-kappaB, Nrf2, and production of ROS.	Isothiocyanates	45-60	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
16506816-1	2006	Early effects (only 1 h of exposure) of three isothiocyanates (benzyl, phenylethyl, and sulforaphane) on nuclear accumulation of thioredoxin, APE/Ref-1, and transcription factors NF-kappaB and Nrf2, as well as production of reactive oxygen species (ROS) and reduced glutathione levels were examined in human adenocarcinoma Caco-2 cells.	Isothiocyanates	46-61	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	142-145
16506816-1	2006	Early effects (only 1 h of exposure) of three isothiocyanates (benzyl, phenylethyl, and sulforaphane) on nuclear accumulation of thioredoxin, APE/Ref-1, and transcription factors NF-kappaB and Nrf2, as well as production of reactive oxygen species (ROS) and reduced glutathione levels were examined in human adenocarcinoma Caco-2 cells.	Isothiocyanates	46-61	nuclear factor kappa B subunit 1	Homo sapiens	179-188
16272172-0	2006	ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.	Isothiocyanates	118-133	mitogen-activated protein kinase 1	Homo sapiens	0-3
16520658-1	2006	Isothiocyanates (ITCs) are a class of well-known cancerpreventive phytochemicals, but are primarily disposed of and concentrated in the urine as N-acetylcysteine conjugates (NAC-ITCs) in vivo.	Isothiocyanates	0-15	synuclein alpha	Homo sapiens	174-177
16272172-0	2006	ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.	Isothiocyanates	118-133	mitogen-activated protein kinase 8	Homo sapiens	8-11
16272172-0	2006	ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.	Isothiocyanates	118-133	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-84
16898867-2	2006	We report that several isothiocyanates (ITCs) that have not been previously examined, 1-methylbutyl ITC in particular, potently and preferentially induce both GST and NQO1 in the rat bladder.	Isothiocyanates	23-38	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	167-171
16454693-8	2006	Other dietary chemicals, including methylenedioxyphenyl (MDP) compounds and isothiocyanates also modulate CYP gene expression.	Isothiocyanates	76-91	peptidylprolyl isomerase G	Homo sapiens	106-109
16898867-2	2006	We report that several isothiocyanates (ITCs) that have not been previously examined, 1-methylbutyl ITC in particular, potently and preferentially induce both GST and NQO1 in the rat bladder.	Isothiocyanates	23-38	glutathione S-transferase kappa 1	Homo sapiens	159-162
16257343-2	2005	We therefore studied the role of cruciferous vegetables in lung cancer after stratifying by GSTM1 and GSTT1 status, two genes implicated in the elimination of isothiocyanates, the likely chemopreventative compound.	Isothiocyanates	159-174	glutathione S-transferase mu 1	Homo sapiens	92-97
16054659-6	2005	Pharmacological and food-derived agents such as dithiolethiones and isothiocyanates trigger the release of Nrf2 from Keap1, allowing it to translocate into the nucleus and stimulate gene transcription.	Isothiocyanates	68-83	nuclear factor, erythroid derived 2, like 2	Mus musculus	107-111
16054659-6	2005	Pharmacological and food-derived agents such as dithiolethiones and isothiocyanates trigger the release of Nrf2 from Keap1, allowing it to translocate into the nucleus and stimulate gene transcription.	Isothiocyanates	68-83	kelch-like ECH-associated protein 1	Mus musculus	117-122
16257343-2	2005	We therefore studied the role of cruciferous vegetables in lung cancer after stratifying by GSTM1 and GSTT1 status, two genes implicated in the elimination of isothiocyanates, the likely chemopreventative compound.	Isothiocyanates	159-174	glutathione S-transferase theta 1	Homo sapiens	102-107
15648258-0	2004	Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transport.	Isothiocyanates	18-33	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	37-69
15845404-4	2005	Ectopic expression of ESP in Arabidopsis thaliana Col-5 under control of the strong viral CaMV 35S promoter altered the glucosinolate product profile from isothiocyanates towards the corresponding nitriles.	Isothiocyanates	155-170	epithiospecifier protein	Arabidopsis thaliana	22-25
15845404-4	2005	Ectopic expression of ESP in Arabidopsis thaliana Col-5 under control of the strong viral CaMV 35S promoter altered the glucosinolate product profile from isothiocyanates towards the corresponding nitriles.	Isothiocyanates	155-170	CONSTANS-like 5	Arabidopsis thaliana	50-55
15740016-2	2005	In this study, we have shown that three isothiocyanates, sulforaphane, erucin, and iberin, are potent inducers of thioredoxin reductase 1 (TrxR1) in human breast cancer MCF-7 cells.	Isothiocyanates	40-55	thioredoxin reductase 1	Homo sapiens	114-137
15740016-2	2005	In this study, we have shown that three isothiocyanates, sulforaphane, erucin, and iberin, are potent inducers of thioredoxin reductase 1 (TrxR1) in human breast cancer MCF-7 cells.	Isothiocyanates	40-55	thioredoxin reductase 1	Homo sapiens	139-144
15989974-0	2005	The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates.	Isothiocyanates	72-87	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	12-17
15989974-0	2005	The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates.	Isothiocyanates	72-87	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-29
15570060-0	2004	Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates.	Isothiocyanates	170-185	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
15570060-0	2004	Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates.	Isothiocyanates	170-185	NAD(P)H dehydrogenase, quinone 1	Mus musculus	56-88
15648258-0	2004	Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transport.	Isothiocyanates	18-33	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	71-76
15113959-3	2004	Cruciferous vegetables contain precursors of isothiocyanates (ITCs), which may be chemopreventive through potent inhibition of phase I, and induction of phase II enzymes, such as glutathione S-transferases (GSTs).	Isothiocyanates	45-60	glutathione S-transferase mu 1	Homo sapiens	207-211
15354323-0	2004	Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21.	Isothiocyanates	74-89	tumor protein p53	Homo sapiens	109-112
15354323-0	2004	Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21.	Isothiocyanates	74-89	H3 histone pseudogene 16	Homo sapiens	117-120
15215608-0	2004	Effects of isothiocyanates on tumor necrosis factor-alpha production by J774A.1 (BALB/c macrophage) cells.	Isothiocyanates	11-26	tumor necrosis factor	Mus musculus	30-57
15450419-0	2004	A mixture of isothiocyanates induces cyclin B1- and p53-mediated cell-cycle arrest and apoptosis of human T lymphoblastoid cells.	Isothiocyanates	13-28	cyclin B1	Homo sapiens	37-46
15450419-0	2004	A mixture of isothiocyanates induces cyclin B1- and p53-mediated cell-cycle arrest and apoptosis of human T lymphoblastoid cells.	Isothiocyanates	13-28	tumor protein p53	Homo sapiens	52-55
15053522-3	2004	In the present study, the ability of six plant-derived isothiocyanates (allyl isothiocyanate, iberverin, erucin, sulforaphane, iberin, and cheirolin) to increase tissue levels of the phase II detoxification enzymes quinone reductase (QR) and glutathione S-transferase (GST) in a variety of rat tissues has been compared.	Isothiocyanates	55-70	hematopoietic prostaglandin D synthase	Rattus norvegicus	242-267
15101756-3	2004	In turn, these compounds react with organic isocyanates or isothiocyanates to give C-6 fluorinated uracils or thiouracils, respectively, in excellent yields.	Isothiocyanates	59-74	complement C6	Homo sapiens	83-86
15053522-3	2004	In the present study, the ability of six plant-derived isothiocyanates (allyl isothiocyanate, iberverin, erucin, sulforaphane, iberin, and cheirolin) to increase tissue levels of the phase II detoxification enzymes quinone reductase (QR) and glutathione S-transferase (GST) in a variety of rat tissues has been compared.	Isothiocyanates	55-70	hematopoietic prostaglandin D synthase	Rattus norvegicus	269-272
15053522-5	2004	All of the other isothiocyanates, however, increased GST and QR activities in the duodenum, forestomach, and/or the urinary bladder of the animals, with the greatest effects being seen in the urinary bladder.	Isothiocyanates	17-32	hematopoietic prostaglandin D synthase	Rattus norvegicus	53-56
15139522-11	2004	The JNK activity was induced by the isothiocyanates and EGCG.	Isothiocyanates	36-51	mitogen-activated protein kinase 8	Homo sapiens	4-7
15623468-1	2004	Cruciferous vegetables contain anticarcinogenic isothiocyanates (ITCs), particularly the potent sulforaphane, which may decrease risk of prostate cancer through induction of phase II enzymes, including glutathione S-transferases (GSTs).	Isothiocyanates	48-63	glutathione S-transferase mu 1	Homo sapiens	230-234
15623468-1	2004	Cruciferous vegetables contain anticarcinogenic isothiocyanates (ITCs), particularly the potent sulforaphane, which may decrease risk of prostate cancer through induction of phase II enzymes, including glutathione S-transferases (GSTs).	Isothiocyanates	65-69	glutathione S-transferase mu 1	Homo sapiens	230-234
14604468-0	2003	Quantitative evaluation of isothiocyanates as substrates and inhibitors of P-glycoprotein.	Isothiocyanates	27-42	ATP binding cassette subfamily B member 1	Homo sapiens	75-89
12425469-0	2002	Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine.	Isothiocyanates	18-33	ATP binding cassette subfamily B member 1	Homo sapiens	41-55
14604468-4	2003	Several prominent dietary isothiocyanates were characterized for their interaction with P-gp and their specific effects on the P-gp export activity of several marker substrates.	Isothiocyanates	26-41	ATP binding cassette subfamily B member 1	Homo sapiens	88-92
14604468-4	2003	Several prominent dietary isothiocyanates were characterized for their interaction with P-gp and their specific effects on the P-gp export activity of several marker substrates.	Isothiocyanates	26-41	ATP binding cassette subfamily B member 1	Homo sapiens	127-131
12585896-5	2003	Optically and chemically stable fluorescent bioconjugates were prepared by spontaneous reaction of the isothiocyanates with monoclonal antibodies anti-CD3 and anti-CD8 in slightly basic solutions.	Isothiocyanates	103-118	CD8a molecule	Homo sapiens	164-167
12171915-1	2002	Dietary isothiocyanates induce apoptosis in various cancer cell lines through a c-Jun N-terminal kinase (JNK)-dependent mechanism.	Isothiocyanates	8-23	mitogen-activated protein kinase 8	Homo sapiens	80-103
12171915-1	2002	Dietary isothiocyanates induce apoptosis in various cancer cell lines through a c-Jun N-terminal kinase (JNK)-dependent mechanism.	Isothiocyanates	8-23	mitogen-activated protein kinase 8	Homo sapiens	105-108
12425469-0	2002	Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine.	Isothiocyanates	18-33	ATP binding cassette subfamily C member 1	Homo sapiens	61-65
12044841-6	2002	In contrast, these isothiocyanates increased LPS-stimulated tumor necrosis factor alpha (TNF-alpha) release, suggesting their selective action on genes activated by LPS.	Isothiocyanates	19-34	tumor necrosis factor	Homo sapiens	60-87
12403303-1	2002	In the reaction of (4-phenyl- or 3,4-diphenyl-5-oxo-1,2,4-triazeolin-1-ylmethyl)-carbohydrazide (IIa, IIb) with isothiocyanates the thiosemicarbazide derivatives [IIIa, b - IXa, b] were obtained.	Isothiocyanates	112-127	ATPase, class II, type 9A	Mus musculus	97-100
12403303-1	2002	In the reaction of (4-phenyl- or 3,4-diphenyl-5-oxo-1,2,4-triazeolin-1-ylmethyl)-carbohydrazide (IIa, IIb) with isothiocyanates the thiosemicarbazide derivatives [IIIa, b - IXa, b] were obtained.	Isothiocyanates	112-127	ATPase, class II, type 9B	Mus musculus	102-105
12044841-6	2002	In contrast, these isothiocyanates increased LPS-stimulated tumor necrosis factor alpha (TNF-alpha) release, suggesting their selective action on genes activated by LPS.	Isothiocyanates	19-34	tumor necrosis factor	Homo sapiens	89-98
11752388-6	2001	The major quantitative trait locus (QTL) affecting nitrile versus isothiocyanate formation was found very close to a gene encoding a homolog of a Brassica napus epithiospecifier protein (ESP), which causes the formation of epithionitriles instead of isothiocyanates during glucosinolate hydrolysis in the seeds of certain Brassicaceae.	Isothiocyanates	250-265	epithiospecifier protein-like	Brassica napus	187-190
11984078-11	2002	Isothiocyanates also induced apoptosis of pre-cancerous cells and tumor cells activated by caspase-8 and potentiated by JNK1.	Isothiocyanates	0-15	caspase 8	Homo sapiens	91-100
11984078-11	2002	Isothiocyanates also induced apoptosis of pre-cancerous cells and tumor cells activated by caspase-8 and potentiated by JNK1.	Isothiocyanates	0-15	mitogen-activated protein kinase 8	Homo sapiens	120-124
11984078-12	2002	The chemopreventive activity of isothiocyanates is influenced by the isothiocyanate bioavailability-as is toxicity, GST polymorphism, protein thiocarbamoylation and probably also by MRP expression.	Isothiocyanates	32-47	MARCKS like 1	Homo sapiens	182-185
11782348-1	2002	Recent studies in cell culture have shown that isothiocyanates (ITCs) induce apoptosis via activation of mitogen-activated protein (MAP) kinases and p53 pathways, suggesting a potential for ITCs or their conjugates to inhibit tumorigenesis during the postinitiation phase.	Isothiocyanates	47-62	transformation related protein 53, pseudogene	Mus musculus	149-152
11782348-1	2002	Recent studies in cell culture have shown that isothiocyanates (ITCs) induce apoptosis via activation of mitogen-activated protein (MAP) kinases and p53 pathways, suggesting a potential for ITCs or their conjugates to inhibit tumorigenesis during the postinitiation phase.	Isothiocyanates	64-68	transformation related protein 53, pseudogene	Mus musculus	149-152
11716714-2	2001	The isothiocyanates were reacted with bovine serum albumin (BSA) following standard procedures and the optical properties of the oligothiophene-BSA conjugates were analyzed as a function of oligomer concentration, time, and irradiation power.	Isothiocyanates	4-19	albumin	Homo sapiens	45-58
11506821-6	2001	Earlier in vivo experiments with rodents indicated that indoles and isothiocyanates, two major groups of glucosinolate breakdown products, attenuate the effects of polycyclic aromatic hydrocarbons (PAHs) and nitrosamines via induction of GST and inhibition of cytochrome-P450 isoenzymes, respectively.	Isothiocyanates	68-83	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	260-275
11672424-5	2001	The ability of hPGDS to catalyse the conjugation of aryl halides and isothiocyanates with GSH was found to be less than that of the rat enzyme.	Isothiocyanates	69-84	prostaglandin D2 synthase	Homo sapiens	15-20
11414690-0	2001	Differential effects of naturally occurring isothiocyanates on the activities of cytochrome P450 2E1 and the mutant P450 2E1 T303A.	Isothiocyanates	44-59	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	81-100
11237388-0	2001	Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK.	Isothiocyanates	60-75	BH3 interacting domain death agonist	Homo sapiens	89-92
11346483-5	2001	Significantly lower concentrations of curcumin(s) than isothiocyanates achieved 50% inhibition of activity of CYP 1A1 and 1A2, while concentrations of C (4 microM), bdmC (2.5 microM) required to inhibit CYP 2B1 were slightly higher than that of PEITC (1.3 microM), suggesting curcumin(s) to be effective inhibitors of CYP 2B1 as well.	Isothiocyanates	55-70	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	110-117
11237388-0	2001	Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK.	Isothiocyanates	60-75	mitogen-activated protein kinase 8	Homo sapiens	145-148
11045782-0	2000	Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk.	Isothiocyanates	18-33	glutathione S-transferase kappa 1	Homo sapiens	67-92
11133247-3	2001	A number of phytochemicals can also potently inhibit CYP2E1 - most notably certain isothiocyanates found in crucifera, such as sulforaphane and phenethylisothiocyanate.	Isothiocyanates	83-98	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	53-59
10397596-4	1999	At lower concentration, phenolic antioxidants and isothiocyanates activate mitogen-activated protein kinase (MAPK; extracellular signal-regulated protein kinase 2, ERK2; and c-Jun N-terminal kinase 1, JNK1) in a concentration-and time-dependent manner.	Isothiocyanates	50-65	mitogen-activated protein kinase 1	Homo sapiens	109-113
10987917-0	2000	Room temperature ring-opening cyclization reactions of 2-vinylaziridines with isocyanates, carbodiimides, and isothiocyanates catalyzed by 2-Vinylaziridines undergo cycloaddition reactions with various heterocumulenes, in the presence of [Pd(OAc)(2)] and PPh(3), at room temperature and 1 atm pressure, regioselectively affording five-membered ring products in moderate to high yields.	Isothiocyanates	110-125	caveolin 1	Homo sapiens	255-261
10936680-0	2000	A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates.	Isothiocyanates	120-135	hematopoietic prostaglandin D synthase	Rattus norvegicus	2-27
10825467-1	2000	The dietary isothiocyanates and cancer chemopreventive agents phenethyl isothiocyanate and allyl isothiocyanate and their cysteine conjugates inhibited the growth and induced apoptosis of human leukaemia HL60 (p53-) and human myeloblastic leukaemia-1 cells (p53+) in vitro.	Isothiocyanates	12-27	tumor protein p53	Homo sapiens	210-213
10825467-1	2000	The dietary isothiocyanates and cancer chemopreventive agents phenethyl isothiocyanate and allyl isothiocyanate and their cysteine conjugates inhibited the growth and induced apoptosis of human leukaemia HL60 (p53-) and human myeloblastic leukaemia-1 cells (p53+) in vitro.	Isothiocyanates	12-27	tumor protein p53	Homo sapiens	258-261
10754276-5	2000	Catalase and bathocuproine, a Cu(I)-specific chelator, inhibited Cu(II)-mediated DNA damage by these isothiocyanates, suggesting involvement of H(2)O(2) and Cu(I).	Isothiocyanates	101-116	catalase	Homo sapiens	0-8
10417337-1	1999	Myrosinase (thioglucoside glucohydrolase; EC 3.2.3.1) is a plant enzyme that hydrolyses glucosinolates, principally to isothiocyanates.	Isothiocyanates	119-134	myrosinase	Raphanus sativus	0-10
11085692-2	2000	Glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) conjugate isothiocyanates leading to more rapid elimination.	Isothiocyanates	65-80	glutathione S-transferase mu 1	Homo sapiens	38-43
11085692-2	2000	Glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) conjugate isothiocyanates leading to more rapid elimination.	Isothiocyanates	65-80	glutathione S-transferase theta 1	Homo sapiens	48-53
11085692-8	2000	This protective effect of isothiocyanates was seen primarily among individuals with homozygous deletion of GSTM1 (0.36 [0.20-0.63]) and particularly with deletion of both GSTM1 and GSTT1 (0.28 [0.13-0.57]).	Isothiocyanates	26-41	glutathione S-transferase mu 1	Homo sapiens	107-112
11085692-8	2000	This protective effect of isothiocyanates was seen primarily among individuals with homozygous deletion of GSTM1 (0.36 [0.20-0.63]) and particularly with deletion of both GSTM1 and GSTT1 (0.28 [0.13-0.57]).	Isothiocyanates	26-41	glutathione S-transferase mu 1	Homo sapiens	171-176
11085692-8	2000	This protective effect of isothiocyanates was seen primarily among individuals with homozygous deletion of GSTM1 (0.36 [0.20-0.63]) and particularly with deletion of both GSTM1 and GSTT1 (0.28 [0.13-0.57]).	Isothiocyanates	26-41	glutathione S-transferase theta 1	Homo sapiens	181-186
10692595-1	2000	Epithiospecifier protein (ESP), a ferrous ion dependent protein, has a potential role in regulating the release of elemental sulphur, nitriles, isothiocyanates and cyanoepithioalkanes from glucosinolates.	Isothiocyanates	144-159	epithiospecifier protein-like	Brassica napus	26-29
10675557-2	2000	The epithiospecifier protein (ESP) is a myrosinase (MYR) cofactor, which is necessary to drive the MYR-catalyzed hydrolysis of some specific glucosinolates towards the production of cyanoepithioalkanes instead of isothiocyanates and nitriles.	Isothiocyanates	213-228	epithiospecifier protein-like	Brassica napus	4-28
10675557-2	2000	The epithiospecifier protein (ESP) is a myrosinase (MYR) cofactor, which is necessary to drive the MYR-catalyzed hydrolysis of some specific glucosinolates towards the production of cyanoepithioalkanes instead of isothiocyanates and nitriles.	Isothiocyanates	213-228	epithiospecifier protein-like	Brassica napus	30-33
10667562-7	2000	The structure-activity relationship of the isothiocyanates also indicated that the ROI-producing activities closely correlated with their GST-inducing potencies.	Isothiocyanates	43-58	hematopoietic prostaglandin D synthase	Rattus norvegicus	138-141
10397596-4	1999	At lower concentration, phenolic antioxidants and isothiocyanates activate mitogen-activated protein kinase (MAPK; extracellular signal-regulated protein kinase 2, ERK2; and c-Jun N-terminal kinase 1, JNK1) in a concentration-and time-dependent manner.	Isothiocyanates	50-65	mitogen-activated protein kinase 1	Homo sapiens	164-168
10397596-4	1999	At lower concentration, phenolic antioxidants and isothiocyanates activate mitogen-activated protein kinase (MAPK; extracellular signal-regulated protein kinase 2, ERK2; and c-Jun N-terminal kinase 1, JNK1) in a concentration-and time-dependent manner.	Isothiocyanates	50-65	mitogen-activated protein kinase 8	Homo sapiens	174-199
10397596-4	1999	At lower concentration, phenolic antioxidants and isothiocyanates activate mitogen-activated protein kinase (MAPK; extracellular signal-regulated protein kinase 2, ERK2; and c-Jun N-terminal kinase 1, JNK1) in a concentration-and time-dependent manner.	Isothiocyanates	50-65	mitogen-activated protein kinase 8	Homo sapiens	201-205
8674048-7	1996	When comparing the kinetics of JNK1 activation by different isothiocyanates, PEITC elicited a sustained activation, whereas 3-phenylpropyl isothiocyanate and 4-phenylbutyl isothiocyanate stimulated transient activations.	Isothiocyanates	60-75	mitogen-activated protein kinase 8	Homo sapiens	31-35
9458080-0	1998	Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.	Isothiocyanates	16-31	caspase 3	Homo sapiens	53-62
9458080-1	1998	Isothiocyanates exert strong anticarcinogenic effects in a number of animal models of cancer, presumably by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome P-450 and/or by induction of phase II detoxifying enzymes.	Isothiocyanates	0-15	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	180-196
9458080-3	1998	Treatment with apoptosis-inducing concentrations of isothiocyanates also caused rapid and transient induction of caspase-3/CPP32-like activity.	Isothiocyanates	52-67	caspase 3	Homo sapiens	113-122
9458080-3	1998	Treatment with apoptosis-inducing concentrations of isothiocyanates also caused rapid and transient induction of caspase-3/CPP32-like activity.	Isothiocyanates	52-67	caspase 3	Homo sapiens	123-128
9458080-4	1998	Furthermore, these isothiocyanates, except phenyl isothiocyanate, stimulated proteolytic cleavage of poly(ADP-ribose) polymerase, which followed the appearance of caspase activity and preceded DNA fragmentation.	Isothiocyanates	19-34	poly(ADP-ribose) polymerase 1	Homo sapiens	101-128
9458080-6	1998	These results suggest that isothiocyanates may induce apoptosis through a caspase-3-dependent mechanism.	Isothiocyanates	27-42	caspase 3	Homo sapiens	74-83
9430725-0	1998	Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates.	Isothiocyanates	95-110	mitogen-activated protein kinase 8	Homo sapiens	24-47
9430725-3	1998	The sustained JNK activation caused by isothiocyanates was associated with apoptosis induction in various cell types.	Isothiocyanates	39-54	mitogen-activated protein kinase 8	Homo sapiens	14-17
9406243-4	1997	DT-diaphorase is induced in many tissues by a wide variety of compounds including dithiolethiones and isothiocyanates.	Isothiocyanates	102-117	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-13
8968058-0	1996	Inhibition of rat liver cytochrome P450 isozymes by isothiocyanates and their conjugates: a structure-activity relationship study.	Isothiocyanates	52-67	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	24-39
8674048-9	1996	Furthermore, different patterns of JNK1 induction by these isothiocyanates may contribute to their distinct chemopreventive efficacies in some animal tumor model studies.	Isothiocyanates	59-74	mitogen-activated protein kinase 8	Homo sapiens	35-39
9681534-4	1998	GSTM1 is involved in the detoxification of various carcinogens, but it also enhances the excretion of isothiocyanates and possibly other enzyme inducers in cruciferous vegetables.	Isothiocyanates	102-117	glutathione S-transferase mu 1	Homo sapiens	0-5
9430725-4	1998	An inhibitor of the caspase/interleukin-1 beta-converting enzyme blocked isothiocyanate-induced apoptosis without inhibiting the JNK activation, which suggests that JNK activation by isothiocyanates is an event that is independent or upstream of the activation of caspase/interleukin-1 beta-converting enzyme proteases.	Isothiocyanates	183-198	mitogen-activated protein kinase 8	Homo sapiens	165-168
1443546-3	1992	Under mild conditions nearly all organic isothiocyanates (R-NCS) react quantitatively with an excess of vicinal dithiols to give rise to five-membered cyclic condensation products with release of the corresponding free amines (R-NH2).	Isothiocyanates	41-56	NLR family pyrin domain containing 4	Homo sapiens	227-232
8050094-6	1994	Our data support the ability of isothiocyanates to inhibit the activity of a number of isozymes of cytochrome P-450.	Isothiocyanates	32-47	uncharacterized protein LOC107819388	Nicotiana tabacum	99-115
7681935-3	1993	Cytochrome P-450 level and monooxygenase activities were decreased by the isothiocyanates and CYB.	Isothiocyanates	74-89	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
33774519-1	2021	Sulforaphane(SFN) and erucin(ERN) are isothiocyanates (ITCs) bearing, respectively, methylsulfinyl and methylsulfanyl groups.	Isothiocyanates	38-53	RNA exonuclease 2	Homo sapiens	13-16
2556881-0	1989	Induction of glutathione S-transferase, placental type in T9 glioma cells by dibutyryladenosine 3",5"-cyclic monophosphate and modification of its expression by naturally occurring isothiocyanates.	Isothiocyanates	181-196	hematopoietic prostaglandin D synthase	Rattus norvegicus	13-38
34717147-1	2021	SFN, a dietary phytochemical, is a significant member of isothiocyanates present in cruciferous vegetables at high levels in broccoli.	Isothiocyanates	57-72	RNA exonuclease 2	Homo sapiens	0-3
34945451-2	2021	The endogenous enzyme myrosinase is responsible for the hydrolysis of glucosinolates, yielding a variety of compounds, including health-promoting isothiocyanates.	Isothiocyanates	146-161	myrosinase	Brassica oleracea	22-32
35580770-8	2022	Among them, glucosinolates can be transformated to isothiocyanates by plant myrosinase or the intestinal flora, which display a variety of activities, such as anti-tumor, anti-inflammatory, antioxidant, antibacterial, treatment of metabolic diseases, central nervous system protection, anti-osteoporosis.	Isothiocyanates	51-66	myrosinase	Raphanus sativus	76-86
35413191-3	2022	It has been demonstrated that 2 may serve as a synthon for (eta5-1,3-(Me3Si)2C5H3)2U(II) fragment in the presence of Ph2E2 (E = S, Se), alkynes, and a variety of hetero-unsaturated molecules such as diazabutadienes, azine (Ph2C N)2, o-benzoquinone, pyridine N-oxide, CS2, isothiocyanates, and organic azides.	Isothiocyanates	272-287	chorionic somatomammotropin hormone 2	Homo sapiens	267-270
291056-1	1979	alpha-Actinin from chicken gizzard labeled with tetramethylrhodamine isothiocyanate has been incorporated into living fibroblast cells by microinjection.	Isothiocyanates	48-83	actinin, alpha 4	Gallus gallus	0-13
291056-6	1979	Control studies in which heat-treated (100 degrees C, 2 min) fluorescent alpha-actinin or tetramethylrhodamine isothiocyanate alone was injected into the cells indicated that the stress fiber and polygonal network labeling was specific for "native" fluorescently labeled alpha-actinin.	Isothiocyanates	90-125	actinin alpha 1	Homo sapiens	271-284
32951477-0	2020	Characterisation of naturally occurring isothiocyanates as glutathione reductase inhibitors.	Isothiocyanates	40-55	glutathione-disulfide reductase	Homo sapiens	59-80
33900772-0	2021	Design and Structure-Activity Relationships of Isothiocyanates as Potent and Selective N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibitors.	Isothiocyanates	47-62	N-acylethanolamine acid amidase	Homo sapiens	87-130
33451160-0	2021	Identification of Phytochemical-Based beta-Catenin Nuclear Localization Inhibitor in NSCLC: Differential Targeting Population from Member of Isothiocyanates.	Isothiocyanates	141-156	catenin beta 1	Homo sapiens	38-50
33451160-4	2021	In the present study, we assessed several representatives of phytochemical categories consisting of alkaloids, chalcones and isothiocyanates for their inhibitory activity to nuclear localization of beta-catenin-an important event for Wnt/beta-catenin pathway activation, in lung cancer cell lines.	Isothiocyanates	125-140	catenin beta 1	Homo sapiens	198-210
33451160-4	2021	In the present study, we assessed several representatives of phytochemical categories consisting of alkaloids, chalcones and isothiocyanates for their inhibitory activity to nuclear localization of beta-catenin-an important event for Wnt/beta-catenin pathway activation, in lung cancer cell lines.	Isothiocyanates	125-140	catenin beta 1	Homo sapiens	238-250
32951477-2	2020	In this regard, we evaluated the naturally occurring isothiocyanates as promising GR inhibitors and elucidated the mechanism of action.	Isothiocyanates	53-68	glutathione-disulfide reductase	Homo sapiens	82-84
31706900-0	2020	A novel isothiocyanate derivative inhibits HIV-1 gene expression and replication by modulating the nuclear matrix associated protein SMAR1.	Isothiocyanates	8-22	BTG3 associated nuclear protein	Homo sapiens	133-138
33030162-4	2020	Reaction of (6-Dipp)CuPPh2 with isocyanates, isothiocyanates and carbon disulfide results in the insertion of the heterocumulene into the Cu-P bond.	Isothiocyanates	45-60	nudix hydrolase 3	Homo sapiens	15-19
31706900-2	2020	Here, we report for the first time, anti-HIV activity of 8 novel isothiocyanate (ITC) derivatives that differentially stabilise SMAR1.	Isothiocyanates	65-79	BTG3 associated nuclear protein	Homo sapiens	128-133
31706900-2	2020	Here, we report for the first time, anti-HIV activity of 8 novel isothiocyanate (ITC) derivatives that differentially stabilise SMAR1.	Isothiocyanates	81-84	BTG3 associated nuclear protein	Homo sapiens	128-133
31706900-9	2020	Taken together, these findings highlight the anti-HIV potential of novel ITC derivatives by the stabilisation of SMAR1 and strongly support further in vivo characterisation and potential translational applications of SCS-OCL-381.	Isothiocyanates	73-76	BTG3 associated nuclear protein	Homo sapiens	113-118
29513045-0	2018	Isothiocyanates: cholinesterase inhibiting, antioxidant, and anti-inflammatory activity.	Isothiocyanates	0-15	butyrylcholinesterase	Homo sapiens	17-31
31756345-5	2019	Bovine serum albumin labeled with fluorescence isothiocyanate assessed megalin expression/endocytic functionality in the proximal tubules epithelial cells (PTECs).	Isothiocyanates	47-61	LDL receptor related protein 2	Rattus norvegicus	71-78
31835873-3	2019	Starting from a 2-amino-pyrimidine scaffold, optimization of anchor moiety and warhead followed by fine-tuning of the required reactivity via scaffold hopping resulted in the isothiocyanate H3R ligand 44.	Isothiocyanates	175-189	histamine receptor H3	Homo sapiens	190-193
31541852-5	2019	Presence of GMG-ITC prior to development of oxidative stress condition, downregulated the expression of cyt-c, p53, Apaf-1, Bax, CASP3, CASP8 and CASP9 genes with concurrent upregulation of Bcl-2 gene in mitochondrial apoptotic signalling pathway.	Isothiocyanates	12-19	tumor protein p53	Homo sapiens	111-114
31541852-5	2019	Presence of GMG-ITC prior to development of oxidative stress condition, downregulated the expression of cyt-c, p53, Apaf-1, Bax, CASP3, CASP8 and CASP9 genes with concurrent upregulation of Bcl-2 gene in mitochondrial apoptotic signalling pathway.	Isothiocyanates	12-19	apoptotic peptidase activating factor 1	Homo sapiens	116-122
31541852-5	2019	Presence of GMG-ITC prior to development of oxidative stress condition, downregulated the expression of cyt-c, p53, Apaf-1, Bax, CASP3, CASP8 and CASP9 genes with concurrent upregulation of Bcl-2 gene in mitochondrial apoptotic signalling pathway.	Isothiocyanates	12-19	BCL2 associated X, apoptosis regulator	Homo sapiens	124-127
31541852-5	2019	Presence of GMG-ITC prior to development of oxidative stress condition, downregulated the expression of cyt-c, p53, Apaf-1, Bax, CASP3, CASP8 and CASP9 genes with concurrent upregulation of Bcl-2 gene in mitochondrial apoptotic signalling pathway.	Isothiocyanates	12-19	caspase 3	Homo sapiens	129-134
31541852-5	2019	Presence of GMG-ITC prior to development of oxidative stress condition, downregulated the expression of cyt-c, p53, Apaf-1, Bax, CASP3, CASP8 and CASP9 genes with concurrent upregulation of Bcl-2 gene in mitochondrial apoptotic signalling pathway.	Isothiocyanates	12-19	caspase 8	Homo sapiens	136-141
31541852-5	2019	Presence of GMG-ITC prior to development of oxidative stress condition, downregulated the expression of cyt-c, p53, Apaf-1, Bax, CASP3, CASP8 and CASP9 genes with concurrent upregulation of Bcl-2 gene in mitochondrial apoptotic signalling pathway.	Isothiocyanates	12-19	caspase 9	Homo sapiens	146-151
31541852-5	2019	Presence of GMG-ITC prior to development of oxidative stress condition, downregulated the expression of cyt-c, p53, Apaf-1, Bax, CASP3, CASP8 and CASP9 genes with concurrent upregulation of Bcl-2 gene in mitochondrial apoptotic signalling pathway.	Isothiocyanates	12-19	BCL2 apoptosis regulator	Homo sapiens	190-195
31541852-6	2019	Protein Multiplex revealed significant decreased in cyt-c, p53, Apaf-1, Bax, CASP8 and CASP9 due to GMG-ITC pre-treatment in oxidative stress condition.	Isothiocyanates	100-107	tumor protein p53	Homo sapiens	59-62
31541852-6	2019	Protein Multiplex revealed significant decreased in cyt-c, p53, Apaf-1, Bax, CASP8 and CASP9 due to GMG-ITC pre-treatment in oxidative stress condition.	Isothiocyanates	100-107	apoptotic peptidase activating factor 1	Homo sapiens	64-70
31541852-6	2019	Protein Multiplex revealed significant decreased in cyt-c, p53, Apaf-1, Bax, CASP8 and CASP9 due to GMG-ITC pre-treatment in oxidative stress condition.	Isothiocyanates	100-107	BCL2 associated X, apoptosis regulator	Homo sapiens	72-75
31541852-6	2019	Protein Multiplex revealed significant decreased in cyt-c, p53, Apaf-1, Bax, CASP8 and CASP9 due to GMG-ITC pre-treatment in oxidative stress condition.	Isothiocyanates	100-107	caspase 8	Homo sapiens	77-82
31541852-6	2019	Protein Multiplex revealed significant decreased in cyt-c, p53, Apaf-1, Bax, CASP8 and CASP9 due to GMG-ITC pre-treatment in oxidative stress condition.	Isothiocyanates	100-107	caspase 9	Homo sapiens	87-92
31612057-5	2019	Treatment with PITC promoted total glutathione depletion in GC cell lines, leading to reactive oxygen species accumulation and DNA damage, which activated the mitochondria-dependent and p53 signaling pathways to trigger apoptosis in GC cells.	Isothiocyanates	15-19	tumor protein p53	Homo sapiens	186-189
31445598-6	2019	If cruciferous plants are consumed without processing, myrosinase enzyme will hydrolyze the glucosinolates to various metabolites, such as isothiocyanates, nitriles, oxazolidine-2-thiones, and indole-3-carbinols.	Isothiocyanates	139-154	myrosinase	Brassica oleracea	55-65
29513045-2	2018	Isothiocyanates have not been previously investigated as potential cholinesterase inhibitors.	Isothiocyanates	0-15	butyrylcholinesterase	Homo sapiens	67-81
29288567-5	2018	In all systems studied, isothiocyanates are strong inducers of detoxification enzyme systems including quinone reductase, glutathione S-transferase, epoxide hydrolase, and UDP-glucuronosyl transferase.	Isothiocyanates	24-39	glutathione S-transferase kappa 1	Homo sapiens	122-147
29924908-3	2018	METHODS AND RESULTS: In the polyposis in rat colon (Pirc) model, single oral administration of SFN and structurally related long-chain isothiocyanates (ITCs) decreased histone deacetylase 3 (HDAC3) expression and increased pH2AX levels markedly in adenomatous colon polyps, extending prior observations on HDAC3 inhibition/turnover in cell-based assays.	Isothiocyanates	152-156	histone deacetylase 3	Rattus norvegicus	168-189
29924908-3	2018	METHODS AND RESULTS: In the polyposis in rat colon (Pirc) model, single oral administration of SFN and structurally related long-chain isothiocyanates (ITCs) decreased histone deacetylase 3 (HDAC3) expression and increased pH2AX levels markedly in adenomatous colon polyps, extending prior observations on HDAC3 inhibition/turnover in cell-based assays.	Isothiocyanates	152-156	histone deacetylase 3	Rattus norvegicus	191-196
29924908-3	2018	METHODS AND RESULTS: In the polyposis in rat colon (Pirc) model, single oral administration of SFN and structurally related long-chain isothiocyanates (ITCs) decreased histone deacetylase 3 (HDAC3) expression and increased pH2AX levels markedly in adenomatous colon polyps, extending prior observations on HDAC3 inhibition/turnover in cell-based assays.	Isothiocyanates	152-156	histone deacetylase 3	Rattus norvegicus	306-311
29578047-7	2018	Among them, we found that isothiocyanates (ITC), insecticidal compounds naturally present in cruciferous plant and perceived as bitter, are good substrates for GSTD2.	Isothiocyanates	26-41	Glutathione S transferase D2	Drosophila melanogaster	160-165
28657737-3	2017	Time-resolved NMR experiments confirmed the pungency mediating mechanism for electrophilic drimane sesquiterpene dialdehydes to be different from that found for other electrophilic pungent agents like isothiocyanates, which have been shown to undergo a covalent binding with cysteine residues in TRPA1.	Isothiocyanates	201-216	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	296-301
28766623-3	2017	Addition of methanol to the compounds derived from addition of Ph2PBpin to carbodiimides, isocyanates, and isothiocyanates resulted in traditional hydrophosphination products.	Isothiocyanates	107-122	polyhomeotic homolog 2	Homo sapiens	63-66
28969043-3	2017	Isothiocyanates, particularly PEITC, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 activity and invasion in various cancer cell lines.	Isothiocyanates	0-15	matrix metallopeptidase 9	Homo sapiens	99-104
28969043-8	2017	Isothiocyanates-mediated inhibition of FAK phosphorylation suppressed phosphorylation of ERK1/2 and Akt in U2OS and A549 cells, along with the translocation of p65 and c-Fos, suggesting that isothiocyanates inhibit MMP-9 expression and cell invasion by blocking phosphorylation of FAK.	Isothiocyanates	0-15	protein tyrosine kinase 2	Homo sapiens	39-42
28969043-0	2017	Isothiocyanates suppress the invasion and metastasis of tumors by targeting FAK/MMP-9 activity.	Isothiocyanates	0-15	protein tyrosine kinase 2	Homo sapiens	76-79
28969043-8	2017	Isothiocyanates-mediated inhibition of FAK phosphorylation suppressed phosphorylation of ERK1/2 and Akt in U2OS and A549 cells, along with the translocation of p65 and c-Fos, suggesting that isothiocyanates inhibit MMP-9 expression and cell invasion by blocking phosphorylation of FAK.	Isothiocyanates	0-15	mitogen-activated protein kinase 3	Homo sapiens	89-95
28969043-0	2017	Isothiocyanates suppress the invasion and metastasis of tumors by targeting FAK/MMP-9 activity.	Isothiocyanates	0-15	matrix metallopeptidase 9	Homo sapiens	80-85
28969043-8	2017	Isothiocyanates-mediated inhibition of FAK phosphorylation suppressed phosphorylation of ERK1/2 and Akt in U2OS and A549 cells, along with the translocation of p65 and c-Fos, suggesting that isothiocyanates inhibit MMP-9 expression and cell invasion by blocking phosphorylation of FAK.	Isothiocyanates	0-15	AKT serine/threonine kinase 1	Homo sapiens	100-103
28969043-8	2017	Isothiocyanates-mediated inhibition of FAK phosphorylation suppressed phosphorylation of ERK1/2 and Akt in U2OS and A549 cells, along with the translocation of p65 and c-Fos, suggesting that isothiocyanates inhibit MMP-9 expression and cell invasion by blocking phosphorylation of FAK.	Isothiocyanates	0-15	RELA proto-oncogene, NF-kB subunit	Homo sapiens	160-163
28969043-8	2017	Isothiocyanates-mediated inhibition of FAK phosphorylation suppressed phosphorylation of ERK1/2 and Akt in U2OS and A549 cells, along with the translocation of p65 and c-Fos, suggesting that isothiocyanates inhibit MMP-9 expression and cell invasion by blocking phosphorylation of FAK.	Isothiocyanates	0-15	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	168-173
28969043-8	2017	Isothiocyanates-mediated inhibition of FAK phosphorylation suppressed phosphorylation of ERK1/2 and Akt in U2OS and A549 cells, along with the translocation of p65 and c-Fos, suggesting that isothiocyanates inhibit MMP-9 expression and cell invasion by blocking phosphorylation of FAK.	Isothiocyanates	0-15	matrix metallopeptidase 9	Homo sapiens	215-220
28969043-8	2017	Isothiocyanates-mediated inhibition of FAK phosphorylation suppressed phosphorylation of ERK1/2 and Akt in U2OS and A549 cells, along with the translocation of p65 and c-Fos, suggesting that isothiocyanates inhibit MMP-9 expression and cell invasion by blocking phosphorylation of FAK.	Isothiocyanates	0-15	protein tyrosine kinase 2	Homo sapiens	281-284
28969043-8	2017	Isothiocyanates-mediated inhibition of FAK phosphorylation suppressed phosphorylation of ERK1/2 and Akt in U2OS and A549 cells, along with the translocation of p65 and c-Fos, suggesting that isothiocyanates inhibit MMP-9 expression and cell invasion by blocking phosphorylation of FAK.	Isothiocyanates	191-206	protein tyrosine kinase 2	Homo sapiens	39-42
28969043-8	2017	Isothiocyanates-mediated inhibition of FAK phosphorylation suppressed phosphorylation of ERK1/2 and Akt in U2OS and A549 cells, along with the translocation of p65 and c-Fos, suggesting that isothiocyanates inhibit MMP-9 expression and cell invasion by blocking phosphorylation of FAK.	Isothiocyanates	191-206	mitogen-activated protein kinase 3	Homo sapiens	89-95
28969043-9	2017	Furthermore, isothiocyanates, abolished MMP-9 expression and tumor metastasis in vivo with the following efficacy: PEITC>BITC>SFN.	Isothiocyanates	13-28	matrix metallopeptidase 9	Homo sapiens	40-45
28969043-10	2017	Thus, isothiocyanates act as anti-metastatic compounds that suppress MMP-9 activity/expression by inhibiting NF-kappaB and AP-1 via suppression of the FAK/ERK and FAK/Akt signaling pathways.	Isothiocyanates	6-21	matrix metallopeptidase 9	Homo sapiens	69-74
28969043-10	2017	Thus, isothiocyanates act as anti-metastatic compounds that suppress MMP-9 activity/expression by inhibiting NF-kappaB and AP-1 via suppression of the FAK/ERK and FAK/Akt signaling pathways.	Isothiocyanates	6-21	protein tyrosine kinase 2	Homo sapiens	151-154
28969043-10	2017	Thus, isothiocyanates act as anti-metastatic compounds that suppress MMP-9 activity/expression by inhibiting NF-kappaB and AP-1 via suppression of the FAK/ERK and FAK/Akt signaling pathways.	Isothiocyanates	6-21	mitogen-activated protein kinase 1	Homo sapiens	155-158
28969043-10	2017	Thus, isothiocyanates act as anti-metastatic compounds that suppress MMP-9 activity/expression by inhibiting NF-kappaB and AP-1 via suppression of the FAK/ERK and FAK/Akt signaling pathways.	Isothiocyanates	6-21	protein tyrosine kinase 2	Homo sapiens	163-166
28969043-10	2017	Thus, isothiocyanates act as anti-metastatic compounds that suppress MMP-9 activity/expression by inhibiting NF-kappaB and AP-1 via suppression of the FAK/ERK and FAK/Akt signaling pathways.	Isothiocyanates	6-21	AKT serine/threonine kinase 1	Homo sapiens	167-170
28422158-0	2017	Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress.	Isothiocyanates	0-15	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	23-29
28422158-0	2017	Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress.	Isothiocyanates	0-15	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	23-27
28422158-0	2017	Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress.	Isothiocyanates	0-15	nuclear receptor subfamily 1, group I, member 3	Mus musculus	58-61
28132875-2	2017	Cruciferous vegetable isothiocyanates (ITCs), namely sulforaphane (SFN) and erucin (ECN), significantly inhibit histone deacetylase (HDAC) activity in human bladder cancer cells representing superficial to invasive biology (59-83% inhibition with 20muM, 48h treatment), and in bladder cancer xenografts (59+-3% ECN inhibition).	Isothiocyanates	22-37	histone deacetylase 9	Homo sapiens	112-131
28132875-2	2017	Cruciferous vegetable isothiocyanates (ITCs), namely sulforaphane (SFN) and erucin (ECN), significantly inhibit histone deacetylase (HDAC) activity in human bladder cancer cells representing superficial to invasive biology (59-83% inhibition with 20muM, 48h treatment), and in bladder cancer xenografts (59+-3% ECN inhibition).	Isothiocyanates	22-37	histone deacetylase 9	Homo sapiens	133-137
27154770-0	2017	Combination of lapatinib with isothiocyanates overcomes drug resistance and inhibits migration of HER2 positive breast cancer cells.	Isothiocyanates	30-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	98-102
27154770-3	2017	The aim of this study was to verify whether combinations of lapatinib with one of isothiocyanates (sulforaphane, erucin or sulforaphene), targeting different levels of HER2 signaling pathway, exert stronger cytotoxic effect than therapy targeting the receptor only, using heterogeneous populations consisting of lapatinib-sensitive and lapatinib-resistant breast cancer cells.	Isothiocyanates	82-97	erb-b2 receptor tyrosine kinase 2	Homo sapiens	168-172
27989132-5	2016	Many dietary phytochemicals with cancer chemopreventive properties, such as polyphenols, isothiocyanates, and triterpenoids, exert antioxidant and anti-inflammatory functions by activating the Nrf2 pathway.	Isothiocyanates	89-104	NFE2 like bZIP transcription factor 2	Homo sapiens	193-197
27639582-4	2016	Kinetic analysis revealed that CdGSTP1-1 displays broad substrate specificity and shows high activity towards halogenated aryl-compounds, isothiocyanates and hydroperoxides.	Isothiocyanates	138-153	glutathione S-transferase P	Camelus dromedarius	31-40
28076424-1	2017	The TRPA1 ion channel is expressed in nociceptive (pain-sensitive) somatosensory neurons and is activated by a wide variety of chemical irritants, such as acrolein in smoke or isothiocyanates in mustard.	Isothiocyanates	176-191	transient receptor potential cation channel subfamily A member 1	Homo sapiens	4-9
27908415-11	2017	The decrease of iodine transfer into the mammary gland and milk is caused by rapeseed meal (RSM) with the glucosinolates and their degradation compounds, e.g. isothiocyanates.	Isothiocyanates	159-174	Weaning weight-maternal milk	Bos taurus	59-63
27911093-2	2017	As we reported previously, Wasabi isothiocyanates (ITCs) are activators of Nrf2-antioxidant response element pathway, and also inhibitors of pro-inflammatory cyclooxygenase-2.	Isothiocyanates	51-55	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79
27911093-2	2017	As we reported previously, Wasabi isothiocyanates (ITCs) are activators of Nrf2-antioxidant response element pathway, and also inhibitors of pro-inflammatory cyclooxygenase-2.	Isothiocyanates	51-55	prostaglandin-endoperoxide synthase 2	Homo sapiens	158-174
27307078-6	2016	ABSTRACT: The TRPA1 ion channel is expressed in nociceptive (pain-sensitive) neurons and responds to a wide variety of chemical irritants, such as acrolein in smoke or isothiocyanates in mustard.	Isothiocyanates	168-183	transient receptor potential cation channel subfamily A member 1	Homo sapiens	14-19