PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22172508-3	2012	Insertion of dMNA effectively delivered substantial amounts of ovalbumin into the skin within 3 min and induced robust antigen-specific antibody responses in the sera of mice.	2,3-dimethylnaphthalene	13-17	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	63-72
20021629-7	2009	RESULTS: The P/PCC analysis identified the DMN well in both study groups, consistent with prior literature.	2,3-dimethylnaphthalene	43-46	crystallin gamma D	Homo sapiens	15-18
18371158-8	2008	Compared to the DMN group, alpha-smooth muscle actin (SMA) and CD68 expression in the DMN-YCHD group was reduced significantly; however, alpha-SMA-positive HSC apoptosis was not observed by confocal microscopy; Fibrogenic proteins (tissue inhibitor matrix proteinases-1 and 2 and matrix metalloproteinase [MMP]-2/14) and cytokines (tumor necrosis factor-alpha and transforming growth factor-beta(1)) were decreased; MMP-9 was significantly upregulated.	2,3-dimethylnaphthalene	86-89	actin gamma 2, smooth muscle	Rattus norvegicus	27-52
19225146-7	2009	When animals were pretreated with the antiemetic palonosetron, a long-term serotonin type 3 (5-HT(3)) receptor antagonist, cisplatin-induced Fos expression was significantly attenuated in the NTS, DMN, and CeA at 6 h but not at 48 h. These results indicate that cisplatin activates a neural system that includes the dorsal vagal complex and forebrain in the musk shrew, which is partially suppressed by a 5-HT(3) receptor antagonist.	2,3-dimethylnaphthalene	197-200	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	141-144
18371158-8	2008	Compared to the DMN group, alpha-smooth muscle actin (SMA) and CD68 expression in the DMN-YCHD group was reduced significantly; however, alpha-SMA-positive HSC apoptosis was not observed by confocal microscopy; Fibrogenic proteins (tissue inhibitor matrix proteinases-1 and 2 and matrix metalloproteinase [MMP]-2/14) and cytokines (tumor necrosis factor-alpha and transforming growth factor-beta(1)) were decreased; MMP-9 was significantly upregulated.	2,3-dimethylnaphthalene	86-89	actin gamma 2, smooth muscle	Rattus norvegicus	54-57
18214934-7	2008	Exposure to 100 and 200 microM ZnSO(4) significantly induced mt2; 10 microM DMN and 20 microM DMN resulted in significantly increased cyp1a1 abundance; and 5 and 10 microM CdCl(2) significantly reduced rag1 expression levels.	2,3-dimethylnaphthalene	76-79	cytochrome P450, family 1, subfamily A	Danio rerio	134-140
18371158-8	2008	Compared to the DMN group, alpha-smooth muscle actin (SMA) and CD68 expression in the DMN-YCHD group was reduced significantly; however, alpha-SMA-positive HSC apoptosis was not observed by confocal microscopy; Fibrogenic proteins (tissue inhibitor matrix proteinases-1 and 2 and matrix metalloproteinase [MMP]-2/14) and cytokines (tumor necrosis factor-alpha and transforming growth factor-beta(1)) were decreased; MMP-9 was significantly upregulated.	2,3-dimethylnaphthalene	86-89	Cd68 molecule	Rattus norvegicus	63-67
18371158-8	2008	Compared to the DMN group, alpha-smooth muscle actin (SMA) and CD68 expression in the DMN-YCHD group was reduced significantly; however, alpha-SMA-positive HSC apoptosis was not observed by confocal microscopy; Fibrogenic proteins (tissue inhibitor matrix proteinases-1 and 2 and matrix metalloproteinase [MMP]-2/14) and cytokines (tumor necrosis factor-alpha and transforming growth factor-beta(1)) were decreased; MMP-9 was significantly upregulated.	2,3-dimethylnaphthalene	86-89	matrix metallopeptidase 9	Rattus norvegicus	416-421
18214934-7	2008	Exposure to 100 and 200 microM ZnSO(4) significantly induced mt2; 10 microM DMN and 20 microM DMN resulted in significantly increased cyp1a1 abundance; and 5 and 10 microM CdCl(2) significantly reduced rag1 expression levels.	2,3-dimethylnaphthalene	76-79	recombination activating 1	Danio rerio	202-206
18214934-7	2008	Exposure to 100 and 200 microM ZnSO(4) significantly induced mt2; 10 microM DMN and 20 microM DMN resulted in significantly increased cyp1a1 abundance; and 5 and 10 microM CdCl(2) significantly reduced rag1 expression levels.	2,3-dimethylnaphthalene	94-97	cytochrome P450, family 1, subfamily A	Danio rerio	134-140
18214934-7	2008	Exposure to 100 and 200 microM ZnSO(4) significantly induced mt2; 10 microM DMN and 20 microM DMN resulted in significantly increased cyp1a1 abundance; and 5 and 10 microM CdCl(2) significantly reduced rag1 expression levels.	2,3-dimethylnaphthalene	94-97	recombination activating 1	Danio rerio	202-206
34818816-1	2022	Carcinogenic N, N-Dimethylnitrosamine (NDMA) has been reported to generate significantly during ozonation of fuel additive unsymmetrical dimethylhydrazine (UDMH), the combined ozone/Peroxy-Monosulfate (O3/PMS) technology was tried for reducing its formation in this study.	2,3-dimethylnaphthalene	13-37	proline rich protein BstNI subfamily 1	Homo sapiens	205-208
12971962-5	2003	ERK1/2, JNK and p70(S6K) activation was associated with hepatocytes proliferation after DMN, while JNK activation was not associated with cholangiocytes proliferation after BDL.	2,3-dimethylnaphthalene	88-91	mitogen activated protein kinase 3	Rattus norvegicus	0-6
8692217-7	1996	Hypersensitivity to DMN of ER-181 cells was completely suppressed by 3-amino-1,2,4-triazole, a known inhibitor of CYP2E1.	2,3-dimethylnaphthalene	20-23	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	114-120
34773973-8	2021	RESULTS: For sFNC, compared with mTBI patients without PTH, mTB with PTH group showed four altered interactions, including decreased interactions in SN-SMN and VN-DMN pairs, increased sFNC in SN-ECN and SMN-DMN pairs.	2,3-dimethylnaphthalene	207-210	non-SMC condensin II complex, subunit G2	Mus musculus	60-63
34747100-6	2022	Meanwhile, RNA-seq analysis predicted the potential regulation of voltage-gated channels, which is according with the molecular docking simulation that both MIL and DMN can bind to Nav 1.2.	2,3-dimethylnaphthalene	165-168	sodium channel, voltage-gated, type II, alpha	Mus musculus	181-188
34773973-8	2021	RESULTS: For sFNC, compared with mTBI patients without PTH, mTB with PTH group showed four altered interactions, including decreased interactions in SN-SMN and VN-DMN pairs, increased sFNC in SN-ECN and SMN-DMN pairs.	2,3-dimethylnaphthalene	163-166	non-SMC condensin II complex, subunit G2	Mus musculus	60-63
35257305-5	2022	Results of seed-based correlational ROI and whole-brain analyses supported our hypothesis that trait dialectical thinking was positively correlated with the strength of the dACC-DMN couplings.	2,3-dimethylnaphthalene	178-181	Acetyl-CoA carboxylase	Drosophila melanogaster	173-177
34180417-8	2021	RESULTS: This study found that the impaired cognition relates to disturbances in the interactions between DMN subsystems but preferentially in core subsystem, and the abnormal regulatory processes of core subsystem were significantly associated with the levels of cerebrospinal fluid Abeta and tau in AD-spectrum patients.	2,3-dimethylnaphthalene	106-109	amyloid beta precursor protein	Homo sapiens	284-289
34180417-8	2021	RESULTS: This study found that the impaired cognition relates to disturbances in the interactions between DMN subsystems but preferentially in core subsystem, and the abnormal regulatory processes of core subsystem were significantly associated with the levels of cerebrospinal fluid Abeta and tau in AD-spectrum patients.	2,3-dimethylnaphthalene	106-109	microtubule associated protein tau	Homo sapiens	294-297
3792215-10	1986	The specific activity of cytochrome P-450 for the metabolism of DMN and B(a)P, however, was significantly reduced in menhaden oil-fed animals by phenobarbital.	2,3-dimethylnaphthalene	64-67	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	25-41
34776436-8	2022	Abeta accumulation in the inferior parietal cortex is associated with lower regional DMN functional connectivity.	2,3-dimethylnaphthalene	85-88	amyloid beta precursor protein	Homo sapiens	0-5
3525573-8	1986	Surprisingly, PI showed less inhibition of the mutagenic activity of DMNA (60% reduction), as compared to the other carcinogens; this indicates that metabolic routes other than the cytochrome P-450-dependent enzyme system may be important for the activation of DMNA.	2,3-dimethylnaphthalene	69-73	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	181-197
31145948-9	2019	The HP-beta-CD also contributed to improved loading of the hydrophobic drug molecules into the DMNA needle tips.	2,3-dimethylnaphthalene	95-99	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	7-14
33168718-8	2020	These results indicate that cholinergic neurons residing in the brainstem DMN control TNF production, revealing a role for brainstem coordination of immunity.	2,3-dimethylnaphthalene	74-77	tumor necrosis factor	Homo sapiens	86-89
6191977-10	1983	Clear dose-dependent effects of DMN were seen in induction of gamma-GT positive foci in the short-term experiment and neoplastic lesions in the long-term one.	2,3-dimethylnaphthalene	32-35	gamma-glutamyltransferase 1	Rattus norvegicus	62-70
33548906-7	2021	RESULTS: We found the correlation of the risk-associated variant belonged to HTR2A polymorphism rs3803189 with the achievements of antidepressant early response, and also with the stronger dynamic changes of DMN.	2,3-dimethylnaphthalene	208-211	5-hydroxytryptamine receptor 2A	Homo sapiens	77-82
31944423-3	2020	Ongoing endogenous prolactin signaling in lacDrd2KO mice was evidenced by increased basal phosphorylation of STAT5b in hypothalamic areas related to food intake, such as the arcuate (ARN), dorsomedial (DMN), and ventromedial nuclei.	2,3-dimethylnaphthalene	202-205	prolactin	Mus musculus	19-28
31944423-3	2020	Ongoing endogenous prolactin signaling in lacDrd2KO mice was evidenced by increased basal phosphorylation of STAT5b in hypothalamic areas related to food intake, such as the arcuate (ARN), dorsomedial (DMN), and ventromedial nuclei.	2,3-dimethylnaphthalene	202-205	signal transducer and activator of transcription 5B	Mus musculus	109-115
31944423-5	2020	Furthermore, Npy expression was increased in the DMN, probably contributing to increased food intake and decreased expression of Uncoupling protein-1 in brown adipose tissue, both events favoring weight gain.	2,3-dimethylnaphthalene	49-52	neuropeptide Y	Mus musculus	13-16
31145948-11	2019	It was found that the value of the scar elevation index was decreased to normal, together with the down regulation of mRNA expressions of Collagen I and transforming growth factor-beta1 (TGF-beta1) following the administration of DMNA containing TA (TA-DMNA).	2,3-dimethylnaphthalene	230-234	transforming growth factor beta 1	Homo sapiens	153-185
31145948-11	2019	It was found that the value of the scar elevation index was decreased to normal, together with the down regulation of mRNA expressions of Collagen I and transforming growth factor-beta1 (TGF-beta1) following the administration of DMNA containing TA (TA-DMNA).	2,3-dimethylnaphthalene	230-234	transforming growth factor beta 1	Homo sapiens	187-196
27221635-12	2016	Moreover, we found a relationship linking the increased CSF lactate and the reduced glucose consumption in the left mPFC, OFC and PHG, owing to the anterior hub of DMN.	2,3-dimethylnaphthalene	164-167	complement factor properdin	Mus musculus	116-120
28549650-12	2017	The PICALM rs3851179 polymorphism significantly affects the DMN network in MCI.	2,3-dimethylnaphthalene	60-63	phosphatidylinositol binding clathrin assembly protein	Homo sapiens	4-10
30765822-6	2019	Analyses showed that dACC GABA levels were positively correlated with resting-state connectivity in the CEN, and negatively associated with functional coupling of the DMN and CEN.	2,3-dimethylnaphthalene	167-170	Acetyl-CoA carboxylase	Drosophila melanogaster	21-25
30082141-4	2018	Therefore, we investigated the association between serotonin transporter (SERT) occupancy by the selective serotonin reuptake inhibitor citalopram and DMN functional connectivity.	2,3-dimethylnaphthalene	151-154	solute carrier family 6 member 4	Homo sapiens	51-72
30082141-4	2018	Therefore, we investigated the association between serotonin transporter (SERT) occupancy by the selective serotonin reuptake inhibitor citalopram and DMN functional connectivity.	2,3-dimethylnaphthalene	151-154	solute carrier family 6 member 4	Homo sapiens	74-78
29505815-3	2018	The objective of this study is to evaluate the effects of DMN fabrication parameters including polymer type, polymer concentration, fabrication and storage temperature, and drying conditions on the activity of the encapsulated therapeutic proteins by employing lysozyme (LYS) as a model protein.	2,3-dimethylnaphthalene	58-61	lysozyme	Homo sapiens	271-274
27616007-1	2016	Dissolving microneedle (DMN), a transdermal drug delivery in which biological drugs are encapsulated in biodegradable and biocompatible polymers, was fabricated using epidermal growth factor (EGF) as a model drug and hyaluronic acid (HA) as a backbone polymeric matrix.	2,3-dimethylnaphthalene	24-27	epidermal growth factor	Homo sapiens	167-190
27616007-1	2016	Dissolving microneedle (DMN), a transdermal drug delivery in which biological drugs are encapsulated in biodegradable and biocompatible polymers, was fabricated using epidermal growth factor (EGF) as a model drug and hyaluronic acid (HA) as a backbone polymeric matrix.	2,3-dimethylnaphthalene	24-27	epidermal growth factor	Homo sapiens	192-195
26308945-3	2015	Here, we introduce the Troy microneedle, which was created by cyclic contact and drying on the pillar (CCDP), and which enabled simultaneous complete and rapid delivery of DMN.	2,3-dimethylnaphthalene	172-175	TNF receptor superfamily member 19	Homo sapiens	23-27
24996404-8	2015	Finally, structural equation modeling confirmed a direct influence of DMN resting-state FC on the association between Abeta-pathology and cognitive impairment.	2,3-dimethylnaphthalene	70-73	amyloid beta precursor protein	Homo sapiens	118-123
27509322-1	2016	The reaction rates of (CH3)2NNO and (CH3CH2)2NNO with NO3 radicals were determined relative to formaldehyde (CH2O) and ethene (CH2CH2) at 298 +- 2 K and 1013 +- 10 hPa in purified air by long path FTIR spectroscopy.	2,3-dimethylnaphthalene	22-31	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
26308945-6	2015	When Troy microneedles were applied to pig cadaver skin, it took only 15 s for over 90% of encapsulated rhodamine B to be delivered, compared to 2 h with application of a traditional DMN patch.	2,3-dimethylnaphthalene	183-186	TNF receptor superfamily member 19	Homo sapiens	5-9
25079796-9	2015	We speculate then that serum effects of VDBP are mediated through changes in DMN structure or function, most probably via Abeta.	2,3-dimethylnaphthalene	77-80	GC vitamin D binding protein	Homo sapiens	40-44
24451655-5	2015	Participants with the high-activity genotype (MAOA-H) showed increased activity in the posterior cingulate part of the DMN.	2,3-dimethylnaphthalene	119-122	monoamine oxidase A	Homo sapiens	46-50