PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11216854-0 2001 Induction of P-glycoprotein mRNA transcripts by cycloheximide in animal tissues: evidence that class I Pgp is transcriptionally regulated whereas class II Pgp is post-transcriptionally regulated. Cycloheximide 48-61 ATP binding cassette subfamily B member 1 Homo sapiens 13-27 11216854-5 2001 In this study, the protein synthesis inhibitor cycloheximide was used as a tool to understand Pgp gene expression and regulation in animal tissues. Cycloheximide 47-60 ATP binding cassette subfamily B member 1 Homo sapiens 94-97 11216854-0 2001 Induction of P-glycoprotein mRNA transcripts by cycloheximide in animal tissues: evidence that class I Pgp is transcriptionally regulated whereas class II Pgp is post-transcriptionally regulated. Cycloheximide 48-61 ATP binding cassette subfamily B member 1 Homo sapiens 103-106 11216854-7 2001 The results showed that cycloheximide significantly induced class II Pgp expression in all tissues examined. Cycloheximide 24-37 ATP binding cassette subfamily B member 1 Homo sapiens 69-72 10441477-5 1999 The MDR1 mRNA half-life was prolonged to >20 h upon treatment with the protein synthesis inhibitor cycloheximide. Cycloheximide 102-115 ATP binding cassette subfamily B member 1 Homo sapiens 4-8 11216854-9 2001 In contrast, the relatively modest increase in class I Pgp expression by cycloheximide was found to be mainly due to increased transcriptional activity. Cycloheximide 73-86 ATP binding cassette subfamily B member 1 Homo sapiens 55-58 11216854-10 2001 On the other hand, cycloheximide induced class III Pgp expression in some tissues while caused decay of class III Pgp mRNA in other tissues. Cycloheximide 19-32 ATP binding cassette subfamily B member 1 Homo sapiens 51-54 11216854-10 2001 On the other hand, cycloheximide induced class III Pgp expression in some tissues while caused decay of class III Pgp mRNA in other tissues. Cycloheximide 19-32 ATP binding cassette subfamily B member 1 Homo sapiens 114-117 11216854-11 2001 The transcriptional and post-transcriptional mechanisms exerted by cycloheximide on Pgp genes are discussed. Cycloheximide 67-80 ATP binding cassette subfamily B member 1 Homo sapiens 84-87 10026303-3 1999 After treatment of MCF-7 cells with cycloheximide (CHX), MDR1 mRNA reached detectable levels, suggesting that MDR1 mRNA expression might be controlled by a labile negative regulatory protein(s) in MCF-7 cells. Cycloheximide 36-49 ATP binding cassette subfamily B member 1 Homo sapiens 57-61 10026303-3 1999 After treatment of MCF-7 cells with cycloheximide (CHX), MDR1 mRNA reached detectable levels, suggesting that MDR1 mRNA expression might be controlled by a labile negative regulatory protein(s) in MCF-7 cells. Cycloheximide 36-49 ATP binding cassette subfamily B member 1 Homo sapiens 110-114 10026303-3 1999 After treatment of MCF-7 cells with cycloheximide (CHX), MDR1 mRNA reached detectable levels, suggesting that MDR1 mRNA expression might be controlled by a labile negative regulatory protein(s) in MCF-7 cells. Cycloheximide 51-54 ATP binding cassette subfamily B member 1 Homo sapiens 57-61 10026303-3 1999 After treatment of MCF-7 cells with cycloheximide (CHX), MDR1 mRNA reached detectable levels, suggesting that MDR1 mRNA expression might be controlled by a labile negative regulatory protein(s) in MCF-7 cells. Cycloheximide 51-54 ATP binding cassette subfamily B member 1 Homo sapiens 110-114 7476894-7 1995 The increased expression was suppressed by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole, an RNA synthesis inhibitor, whereas the protein synthesis inhibitor cycloheximide enhanced the expression several-fold, suggesting that induction of mdr1 by these analogues is regulated at both the transcriptional and post-transcriptional levels. Cycloheximide 161-174 ATP binding cassette subfamily B member 1 Homo sapiens 242-246