PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9632527-2 1998 IFN-gamma specific transcripts were clearly detected in rat astrocytes and were upregulated after treatment with IFN-gamma itself or cycloheximide. Cycloheximide 133-146 interferon gamma Rattus norvegicus 0-9 15287883-7 2004 The delayed increase in NCX activity by IFN-gamma for 24 h was blocked by the protein synthesis inhibitor cycloheximide and actinomycin D. Cycloheximide 106-119 interferon gamma Rattus norvegicus 40-49 9632527-3 1998 In microglial cells, IFN-gamma transcripts were barely detectable in basal conditions and were upregulated by lipopolysaccharide and, to a lesser extent, by IFN-gamma or cycloheximide. Cycloheximide 170-183 interferon gamma Rattus norvegicus 21-30 1847861-0 1991 Cycloheximide inhibits interferon-gamma-induced class II major histocompatibility complex antigen expression in cultured rat thyroid cells. Cycloheximide 0-13 interferon gamma Rattus norvegicus 23-39 8933170-6 1996 While the enhancing SLO effect on NAT could not be neutralized by the inhibitor of transcription actinomycin D, NAT stimulation by IFN gamma was abolished by actinomycin D and by the inhibitor of translation, cycloheximide. Cycloheximide 209-222 interferon gamma Rattus norvegicus 131-140 9203943-7 1997 Cycloheximide prevented the effects of IEL supernatant and of rIFN gamma on TER. Cycloheximide 0-13 interferon gamma Rattus norvegicus 62-72 8719803-13 1995 Cycloheximide (1 microM) abolished induction of L-arginine transport and nitrite accumulation in response to LPS and IFN-gamma. Cycloheximide 0-13 interferon gamma Rattus norvegicus 117-126 7530691-7 1994 was stimulated by the cytokines interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha), an effect enhanced by endotoxin [lipopolysaccharide (LPS)], reduced by the competitive inhibitor of L-arginine metabolism, NG-monomethyl-L-arginine (L-NMMA) and inhibited by cycloheximide. Cycloheximide 281-294 interferon gamma Rattus norvegicus 32-48 7530691-7 1994 was stimulated by the cytokines interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha), an effect enhanced by endotoxin [lipopolysaccharide (LPS)], reduced by the competitive inhibitor of L-arginine metabolism, NG-monomethyl-L-arginine (L-NMMA) and inhibited by cycloheximide. Cycloheximide 281-294 interferon gamma Rattus norvegicus 50-59 8301134-2 1994 Treatment of macrophages from BCG-resistant mice with 1 U of rIFN-gamma induced transient I-A expression that decayed in the presence of cycloheximide. Cycloheximide 137-150 interferon gamma Rattus norvegicus 61-71 7508406-4 1994 Cycloheximide potentiated the expression of iNOS mRNA in SMCs in culture stimulated with LPS+IFN gamma but attenuated the response in aortic strips. Cycloheximide 0-13 interferon gamma Rattus norvegicus 93-102 7689840-8 1993 Induction of GTPCH mRNA was apparent by 2 h, peaked at 4 h, and was sustained at high levels for at least 24 h. Induction of GTPCH mRNA by LPS/IFN was substantially enhanced by cycloheximide, suggesting that mRNA levels are depressed by a labile protein. Cycloheximide 177-190 interferon gamma Rattus norvegicus 143-146 1847717-8 1991 Macrophages were primed with low doses of rIFN-gamma in order to induce transient, cycloheximide-sensitive Ia expression. Cycloheximide 83-96 interferon gamma Rattus norvegicus 42-52 1847717-9 1991 The cells were then treated with high doses of rIFN-gamma in order to induce persistent, cycloheximide-resistant Ia expression. Cycloheximide 89-102 interferon gamma Rattus norvegicus 47-57 2115429-11 1990 The decrease in hybridization signal for BGP mRNA was detectable by 1 h after IFN exposure and continued to decline at 6 and 24 h. Treatment with cycloheximide (5 micrograms/ml) blocked the inhibitory effect of IFN on steady state levels of BGP mRNA. Cycloheximide 146-159 interferon gamma Rattus norvegicus 78-81 2115429-11 1990 The decrease in hybridization signal for BGP mRNA was detectable by 1 h after IFN exposure and continued to decline at 6 and 24 h. Treatment with cycloheximide (5 micrograms/ml) blocked the inhibitory effect of IFN on steady state levels of BGP mRNA. Cycloheximide 146-159 interferon gamma Rattus norvegicus 211-214 2115543-7 1990 Addition of protein or RNA synthesis inhibitors (cycloheximide, emetine, actinomycin D) during exposure to rIL-2 and rIFN-gamma totally abrogated the ability of macrophages to express this effector reaction; inhibitors of protein kinase C, PG, or calcium redistribution had no effect. Cycloheximide 49-62 interferon gamma Rattus norvegicus 117-127 2180586-5 1990 Treatment of these cells with rIFN-gamma resulted in a cycloheximide resistant Ia expression of both parental haplotypes. Cycloheximide 55-68 interferon gamma Rattus norvegicus 30-40 2832315-4 1988 The enhancing effect of rIFN-gamma on the respiratory response of PMN was not blocked by polymixin B sulphate, but an anti-rIFN-gamma monoclonal antibody and cycloheximide and actinomycin D were effective inhibitors. Cycloheximide 158-171 interferon gamma Rattus norvegicus 24-34 3933177-2 1985 Cycloheximide prevented the induction of these mRNAs when rIFN-gamma, but not rIFN-alpha 2, was the inducer. Cycloheximide 0-13 interferon gamma Rattus norvegicus 58-68 3040496-4 1987 The induction of class I proteins by interferon-gamma was nearly completely abolished by cycloheximide. Cycloheximide 89-102 interferon gamma Rattus norvegicus 37-53 26212436-6 2015 Cycloheximide chase analysis revealed that TNF-alpha (10 ng/ml) alone or in combination with IFN-gamma (5 ng/ml) accelerated the degradation of Cx43 protein in cultured spinal astrocytes. Cycloheximide 0-13 interferon gamma Rattus norvegicus 93-102 3155725-10 1985 The turnover of the rIFN-gamma receptor was measured by inhibiting protein synthesis with cycloheximide and the half-life of this receptor was found to be 2 h. The unglycosylated rIFN-gamma was bound to cellular receptors with an affinity similar to that previously reported for natural IFN-gamma. Cycloheximide 90-103 interferon gamma Rattus norvegicus 20-30