PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8311923-3 1993 RESULTS: Protein synthesis inhibition with cycloheximide or actinomycin D resulted in complete abrogation of the stimulation of PGE2 production by IL-1 beta, TNF alpha, and EGF. Cycloheximide 43-56 epidermal growth factor Homo sapiens 173-176 18638274-7 2008 Interestingly, EGF prevention of apoptosis induced by tumor necrosis factor-alpha in the face of cycloheximide blockade of protein translation occurs via a different set of pathways as the simultaneous inhibition of extracellular signal-regulated kinase, Rac, and PI3K signaling did not eliminate EGF from rescuing fibroblasts in the face of this cytokine. Cycloheximide 97-110 epidermal growth factor Homo sapiens 15-18 11787064-9 2002 EGF and bFGF were able both to cooperate with cycloheximide, an inhibitor of protein synthesis, to augment the expression of SAMDC mRNA. Cycloheximide 46-59 epidermal growth factor Homo sapiens 0-3 9895307-4 1999 The increase in p21/CIP1 mRNA upon addition of EGF was rapid, and was enhanced in the presence of cycloheximide. Cycloheximide 98-111 epidermal growth factor Homo sapiens 47-50 9247974-4 1997 On the other hand, cyclooxygenase (COX) activity was increased (1.6-fold) within 2 h after the EGF-treatment and the induced activity was inhibited by cycloheximide. Cycloheximide 151-164 epidermal growth factor Homo sapiens 95-98 8360167-9 1993 The induction of the 12-lipoxygenase mRNA by EGF was completely blocked by 35 microM cycloheximide, if present in culture medium during EGF treatment, indicating that a de novo protein biosynthesis was essential for EGF-induced 12-lipoxygenase mRNA expression. Cycloheximide 85-98 epidermal growth factor Homo sapiens 45-48 8360167-9 1993 The induction of the 12-lipoxygenase mRNA by EGF was completely blocked by 35 microM cycloheximide, if present in culture medium during EGF treatment, indicating that a de novo protein biosynthesis was essential for EGF-induced 12-lipoxygenase mRNA expression. Cycloheximide 85-98 epidermal growth factor Homo sapiens 136-139 8360167-9 1993 The induction of the 12-lipoxygenase mRNA by EGF was completely blocked by 35 microM cycloheximide, if present in culture medium during EGF treatment, indicating that a de novo protein biosynthesis was essential for EGF-induced 12-lipoxygenase mRNA expression. Cycloheximide 85-98 epidermal growth factor Homo sapiens 136-139 20351270-7 2010 Time-course experiments and incubation with cycloheximide demonstrated that E6 alternative splicing is a direct and reversible effect of EGF signal transduction, not depending on de novo protein synthesis. Cycloheximide 44-57 epidermal growth factor Homo sapiens 137-140 17115938-6 2007 This suppressive effect of EGF on the sensitivity to NaHS was inhibited by cycloheximide, indicating that de novo protein synthesis was required for the suppression of H2S sensitivity. Cycloheximide 75-88 epidermal growth factor Homo sapiens 27-30 16113838-8 2005 However, the induction of TF was abrogated by cycloheximide as well as actinomycin-D, inhibitors or protein- and mRNA-synthesis, respectively, demonstrating that EGF mediates its effect through activation of the TF gene. Cycloheximide 46-59 epidermal growth factor Homo sapiens 162-165 10491655-7 1999 Inhibitors of protein synthesis (cycloheximide) and RNA synthesis (actinomycin D, and 5,6-dichloro-1-beta-ribofuranosyl benzimidazole) completely abrogated the EGF-induced LDH A mRNA expression, indicating that EGF increased LDH A mRNA levels through a transcriptional mechanism, which probably involves protein synthesis. Cycloheximide 33-46 epidermal growth factor Homo sapiens 160-163 12168008-6 1998 Cycloheximide, a well-known inhibitor of protein synthesis, showed an effect similar to the inhibition of protein kinases;it not only inhibited the basal activity of GnT-V, but also abolished the inducing stimulation of GnT-V by EGF of PMA. Cycloheximide 0-13 epidermal growth factor Homo sapiens 229-232 8980292-5 1997 Stimulation by EGF was an actinomycin D- and cycloheximide-sensitive process. Cycloheximide 45-58 epidermal growth factor Homo sapiens 15-18 8162329-7 1993 The induction of ODC by EGF was inhibited by pretreatment of cultures with either cycloheximide or actinomycin D, suggesting that both protein synthesis and gene transcription are important in the EGF induction of ODC. Cycloheximide 82-95 epidermal growth factor Homo sapiens 24-27 8162329-7 1993 The induction of ODC by EGF was inhibited by pretreatment of cultures with either cycloheximide or actinomycin D, suggesting that both protein synthesis and gene transcription are important in the EGF induction of ODC. Cycloheximide 82-95 epidermal growth factor Homo sapiens 197-200 2173488-6 1990 Cycloheximide and actinomycin D were also inhibitory to enzyme induction, indicating that enhancement of enzyme activity by EGF and cAMP was not due to post-translational modification. Cycloheximide 0-13 epidermal growth factor Homo sapiens 124-127 8480471-8 1993 By contrast, the addition of cycloheximide (5 x 10(-5) mol/l) dramatically reduced the secretion of immunoreactive EGF. Cycloheximide 29-42 epidermal growth factor Homo sapiens 115-118 1483963-2 1992 In the present study we investigated the effect of insulinlike growth factor-1, insulin, and epidermal growth factor on cell death induced by cycloheximide in the confluent MCF-7 cells, and correlated this effect to the inhibition rate of protein synthesis. Cycloheximide 142-155 epidermal growth factor Homo sapiens 93-116 2968288-6 1988 Induction of cyclooxygenase by EGF and TGF-beta also was prevented by cycloheximide but not by actinomycin D. Cycloheximide 70-83 epidermal growth factor Homo sapiens 31-34 2114514-1 1990 In an attempt to elucidate possible mechanism(s) for stimulated arachidonic acid metabolism by phorbol 12-myristate 13-acetate (PMA) and epidermal growth factor (EGF) in porcine thyroid cells, we examined the effects of protein kinase inhibitors, isoquinolinesulfonamide derivatives (H-7 and HA-1004), and cycloheximide. Cycloheximide 306-319 epidermal growth factor Homo sapiens 162-165 2114514-2 1990 The production of PGE2 stimulated by either PMA or EGF was strongly inhibited by H-7, with an ID50 value of approximately 20 to 25 mumol/L in each case, as well as by cycloheximide, with an ID50 value of less than 0.5 micrograms/mL in each case. Cycloheximide 167-180 epidermal growth factor Homo sapiens 51-54 2114514-5 1990 The EGF- and PMA-stimulated release of 3H-arachidonic acid from the cells was also strongly inhibited by H-7 and cycloheximide. Cycloheximide 113-126 epidermal growth factor Homo sapiens 4-7 2492191-4 1989 Cycloheximide potentiated the c-fos induction by both EGF and antibody. Cycloheximide 0-13 epidermal growth factor Homo sapiens 54-57 2169831-9 1990 The increase in cell surface uPA produced by exposure to EGF required protein synthesis and could be blocked by cycloheximide. Cycloheximide 112-125 epidermal growth factor Homo sapiens 57-60 3139271-7 1988 Cycloheximide added before, at the same time as, or up to 30-60 min after epidermal growth factor completely abolished the stimulation. Cycloheximide 0-13 epidermal growth factor Homo sapiens 74-97 6319448-13 1984 Down-regulation of EGF receptors was reversible, with 50% recovery by 16 h. However, cycloheximide (10 micrograms/ml) blocked EGF-induced down-regulation and receptor recovery. Cycloheximide 85-98 epidermal growth factor Homo sapiens 19-22 3291183-3 1988 The stimulation appeared at 3-6 h of incubation and lasted at least 24 h. It was suppressed by EGF antibodies and blocked by protein synthesis inhibitor cycloheximide. Cycloheximide 153-166 epidermal growth factor Homo sapiens 95-98 6319448-13 1984 Down-regulation of EGF receptors was reversible, with 50% recovery by 16 h. However, cycloheximide (10 micrograms/ml) blocked EGF-induced down-regulation and receptor recovery. Cycloheximide 85-98 epidermal growth factor Homo sapiens 126-129 6197492-8 1984 When cycloheximide was added 1 h before EGF, ornithine decarboxylase activity was obliterated. Cycloheximide 5-18 epidermal growth factor Homo sapiens 40-43 26620226-7 2016 This EGF-mediated increase in HIF-1alpha protein was blocked through inhibition of translation by cycloheximide. Cycloheximide 98-111 epidermal growth factor Homo sapiens 5-8 24484548-9 2014 Characterization in fibroblasts showed that potentiation of the EGF pathway was significant after 60 minutes of DHT exposure and persisted in the presence of the translational inhibitor cycloheximide. Cycloheximide 186-199 epidermal growth factor Homo sapiens 64-67 22689575-8 2012 Cycloheximide, a translation elongation inhibitor known to augment intracellular amino acid levels, prevented the effect of bafilomycin on amino acids levels and completely reversed its inhibition of EGF-induced mTORC1 activation. Cycloheximide 0-13 epidermal growth factor Homo sapiens 200-203