PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7577656-9 1995 Cycloheximide (CHX) incubation abolished the inhibitory effect of IFN-alpha on GM-CSF expression, suggesting the requirement of a labile protein. Cycloheximide 0-13 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 79-85 7577656-9 1995 Cycloheximide (CHX) incubation abolished the inhibitory effect of IFN-alpha on GM-CSF expression, suggesting the requirement of a labile protein. Cycloheximide 15-18 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 79-85 7930569-4 1994 However, comparative studies using extracts of D10.G4.1 cells treated with the cellular activators Con A and PMA and the inhibitors cycloheximide and cyclosporin A indicated that the binding activities to the conserved elements in the IL-5 and GM-CSF genes (designated NF-IL-5A and NF-GM-CSFA, respectively) are regulated by different signaling pathways. Cycloheximide 132-145 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 244-250 2824613-14 1987 However, both mediators act by inducing the transcription of the HDC gene and de novo synthesis of this enzyme since actinomycin D or cycloheximide abolish GM-CSF-or IL-3-induced histamine-producing cell-stimulating activity. Cycloheximide 134-147 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 156-162 1535090-10 1992 The protein synthesis inhibitor cycloheximide abrogated GM-CSF receptor up-regulation induced by both rMuIL-3 and rMuGM-CSF, whereas actinomycin D inhibited only the second (8-24 h) phase of GM-CSF receptor up-regulation induced by exposure to high concentrations rMuGM-CSF (10 ng/ml). Cycloheximide 32-45 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 56-62 1535090-10 1992 The protein synthesis inhibitor cycloheximide abrogated GM-CSF receptor up-regulation induced by both rMuIL-3 and rMuGM-CSF, whereas actinomycin D inhibited only the second (8-24 h) phase of GM-CSF receptor up-regulation induced by exposure to high concentrations rMuGM-CSF (10 ng/ml). Cycloheximide 32-45 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 117-123 1993549-6 1991 GM-CSF mRNA was, however, detected in the tumor cells in the presence of an mRNA-stabilizing agent, cycloheximide, suggesting the possibility that the tumor cells of this type were transcribing GM-CSF gene, and secreting it in undetectable levels; (3) in culture of the 4 remaining poorly or non-metastatic tumors, neither CSF activity nor GM-CSF mRNA could be detected even in the presence of cycloheximide. Cycloheximide 100-113 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 0-6 1993549-6 1991 GM-CSF mRNA was, however, detected in the tumor cells in the presence of an mRNA-stabilizing agent, cycloheximide, suggesting the possibility that the tumor cells of this type were transcribing GM-CSF gene, and secreting it in undetectable levels; (3) in culture of the 4 remaining poorly or non-metastatic tumors, neither CSF activity nor GM-CSF mRNA could be detected even in the presence of cycloheximide. Cycloheximide 394-407 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 0-6 3123388-7 1988 CSF production by peritoneal adherent cells was completely inhibited by cycloheximide (50 micrograms/ml), and neither the elimination of T cells from the peritoneal adherent cells by treating them with anti-Thy-1.2 antibody plus complement nor the addition of T cells affected CSF production. Cycloheximide 72-85 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 0-3 9880508-12 1999 Northern analysis demonstrates that cycloheximide treatment abrogates the capacity of GM-CSF to decrease beta5 mRNA levels. Cycloheximide 36-49 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 86-92 6602193-9 1983 Only 8% secretion was noted at 4 degrees C; however, this increased to 70% to 80% at 37 degrees C. Development of binding sites in vitro appeared to require new protein synthesis, since addition of 1 microgram/ml cycloheximide during the preincubation prevented the subsequent CSF binding. Cycloheximide 213-226 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 277-280