PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2766930-1 1989 Simultaneous treatment of the rat hepatocyte-derived cell line LCS7 with cycloheximide and polycyclic aromatic compounds increased CYP1A1 (cytochrome P450c) gene transcription rate four- to sixfold and mRNA levels 20-fold relative to the levels in cells treated with inducers alone. Cycloheximide 73-86 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 131-137 2766930-1 1989 Simultaneous treatment of the rat hepatocyte-derived cell line LCS7 with cycloheximide and polycyclic aromatic compounds increased CYP1A1 (cytochrome P450c) gene transcription rate four- to sixfold and mRNA levels 20-fold relative to the levels in cells treated with inducers alone. Cycloheximide 73-86 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 139-155 2766930-4 1989 Thus, treatment with cycloheximide revealed two phases to the response of the CYP1A1 gene to inducer. Cycloheximide 21-34 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 78-84 2766930-9 1989 All of these exhibited elevated levels of CYP1A1 mRNA following simultaneous treatment with inducer and cycloheximide; transcription rate was superinduced three- to fourfold in primary hepatocytes, and CYP1A1 mRNA levels were superinduced 20- to 25-fold in both kidney and lung explants. Cycloheximide 104-117 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 42-48 2458855-2 1988 AHH activity was induced by treatment with benz[a]anthracene and combined treatment with cycloheximide for an initial short period during the induction enhanced benz[a]anthracene-inducible AHH activity. Cycloheximide 89-102 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 0-3 2458855-5 1988 In addition, 3-methoxybenzamide was found to further increase the enhancing effects of cycloheximide on benz[a]anthracene induction of AHH. Cycloheximide 87-100 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 135-138 2458855-2 1988 AHH activity was induced by treatment with benz[a]anthracene and combined treatment with cycloheximide for an initial short period during the induction enhanced benz[a]anthracene-inducible AHH activity. Cycloheximide 89-102 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 189-192 7441519-4 1980 TCDD-induction of AHH and cytochrome P-450 contents can be completely inhibited by a single pretreatment with either actinomycin D or cycloheximide, suggesting TCDD induces de novo synthesis of specific proteins. Cycloheximide 134-147 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 18-21 1995646-4 1991 Treatment of adult aortic SMC with cycloheximide dramatically elevated CypIa1 mRNA levels and had little effect on the amount of this mRNA in pup SMC. Cycloheximide 35-48 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 71-77 9512490-14 1998 The dependence of CYP1A1 induction on dexamethasone or cycloheximide suggests that derepression by a glucocorticoid receptor-modulated negative-acting factor of CYP1A1 gene expression might be critical to induction by metyrapone. Cycloheximide 55-68 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 18-24 9512490-14 1998 The dependence of CYP1A1 induction on dexamethasone or cycloheximide suggests that derepression by a glucocorticoid receptor-modulated negative-acting factor of CYP1A1 gene expression might be critical to induction by metyrapone. Cycloheximide 55-68 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 161-167 9512490-7 1998 CYP1A1 mRNA is also induced when hepatocytes are treated with metyrapone in combination with the protein synthesis inhibitor cycloheximide but not with dexamethasone in combination with cycloheximide, indicating that CYP1A1 mRNA induction is strictly dependent on the presence of metyrapone and suggesting that the metyrapone-associated induction of CYP1A1 mRNA is dependent on a loss of a constitutively expressed protein that functions to suppress CYP1A1 gene expression. Cycloheximide 125-138 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 0-6 9512490-7 1998 CYP1A1 mRNA is also induced when hepatocytes are treated with metyrapone in combination with the protein synthesis inhibitor cycloheximide but not with dexamethasone in combination with cycloheximide, indicating that CYP1A1 mRNA induction is strictly dependent on the presence of metyrapone and suggesting that the metyrapone-associated induction of CYP1A1 mRNA is dependent on a loss of a constitutively expressed protein that functions to suppress CYP1A1 gene expression. Cycloheximide 125-138 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 217-223 9512490-7 1998 CYP1A1 mRNA is also induced when hepatocytes are treated with metyrapone in combination with the protein synthesis inhibitor cycloheximide but not with dexamethasone in combination with cycloheximide, indicating that CYP1A1 mRNA induction is strictly dependent on the presence of metyrapone and suggesting that the metyrapone-associated induction of CYP1A1 mRNA is dependent on a loss of a constitutively expressed protein that functions to suppress CYP1A1 gene expression. Cycloheximide 125-138 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 217-223 9512490-7 1998 CYP1A1 mRNA is also induced when hepatocytes are treated with metyrapone in combination with the protein synthesis inhibitor cycloheximide but not with dexamethasone in combination with cycloheximide, indicating that CYP1A1 mRNA induction is strictly dependent on the presence of metyrapone and suggesting that the metyrapone-associated induction of CYP1A1 mRNA is dependent on a loss of a constitutively expressed protein that functions to suppress CYP1A1 gene expression. Cycloheximide 125-138 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 217-223 1995646-5 1991 That the cycloheximide effect in adult SMC was due to enhanced transcription of the CypIa1 gene was demonstrated by 1) the ability of actinomycin D to completely block the cycloheximide-induced increase in steady-state mRNA levels, and 2) the increased transcription rate of the CypIa1 gene in cycloheximide-treated adult nuclei determined via nuclear transcription assays. Cycloheximide 9-22 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 84-90 1995646-5 1991 That the cycloheximide effect in adult SMC was due to enhanced transcription of the CypIa1 gene was demonstrated by 1) the ability of actinomycin D to completely block the cycloheximide-induced increase in steady-state mRNA levels, and 2) the increased transcription rate of the CypIa1 gene in cycloheximide-treated adult nuclei determined via nuclear transcription assays. Cycloheximide 9-22 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 279-285 1995646-5 1991 That the cycloheximide effect in adult SMC was due to enhanced transcription of the CypIa1 gene was demonstrated by 1) the ability of actinomycin D to completely block the cycloheximide-induced increase in steady-state mRNA levels, and 2) the increased transcription rate of the CypIa1 gene in cycloheximide-treated adult nuclei determined via nuclear transcription assays. Cycloheximide 172-185 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 84-90 1995646-5 1991 That the cycloheximide effect in adult SMC was due to enhanced transcription of the CypIa1 gene was demonstrated by 1) the ability of actinomycin D to completely block the cycloheximide-induced increase in steady-state mRNA levels, and 2) the increased transcription rate of the CypIa1 gene in cycloheximide-treated adult nuclei determined via nuclear transcription assays. Cycloheximide 172-185 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 279-285 1995646-5 1991 That the cycloheximide effect in adult SMC was due to enhanced transcription of the CypIa1 gene was demonstrated by 1) the ability of actinomycin D to completely block the cycloheximide-induced increase in steady-state mRNA levels, and 2) the increased transcription rate of the CypIa1 gene in cycloheximide-treated adult nuclei determined via nuclear transcription assays. Cycloheximide 172-185 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 84-90 1995646-5 1991 That the cycloheximide effect in adult SMC was due to enhanced transcription of the CypIa1 gene was demonstrated by 1) the ability of actinomycin D to completely block the cycloheximide-induced increase in steady-state mRNA levels, and 2) the increased transcription rate of the CypIa1 gene in cycloheximide-treated adult nuclei determined via nuclear transcription assays. Cycloheximide 172-185 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 279-285