PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8694789-6 1996 Cycloheximide, which partly inhibited rapid ODC degradation caused by hypertonic shock, also part inhibited the increase in the ratio of ODC-antizyme complex total ODC. Cycloheximide 0-13 ornithine decarboxylase 1 Rattus norvegicus 44-47 9490031-9 1998 Ornithine decarboxylase activity was completely suppressed but that of aspartate transcarbamoylase was further increased by cycloheximide treatment. Cycloheximide 124-137 ornithine decarboxylase 1 Rattus norvegicus 0-23 10070056-11 1999 Addition of cycloheximide during ASN and ASN plus EGF treatment completely inhibited ODC activity without affecting the level of ODC protein. Cycloheximide 12-25 ornithine decarboxylase 1 Rattus norvegicus 85-88 8694789-6 1996 Cycloheximide, which partly inhibited rapid ODC degradation caused by hypertonic shock, also part inhibited the increase in the ratio of ODC-antizyme complex total ODC. Cycloheximide 0-13 ornithine decarboxylase 1 Rattus norvegicus 137-140 7543894-7 1995 Cycloheximide rapidly diminished cochlear ODC activity and expression of ODC protein. Cycloheximide 0-13 ornithine decarboxylase 1 Rattus norvegicus 42-45 7543894-7 1995 Cycloheximide rapidly diminished cochlear ODC activity and expression of ODC protein. Cycloheximide 0-13 ornithine decarboxylase 1 Rattus norvegicus 73-76 8224368-4 1993 Its effect on ODC was completely prevented by cycloheximide, that on SAT only partially. Cycloheximide 46-59 ornithine decarboxylase 1 Rattus norvegicus 14-17 24190557-5 1993 This effect of zinc in mitogen activated thymocytes may be due to the stabilization of ODC, which was found to decay with a half life of 65 min after the block of protein synthesis with cycloheximide. Cycloheximide 186-199 ornithine decarboxylase 1 Rattus norvegicus 87-90 2914963-4 1989 The induction of ornithine decarboxylase by both NGF and PMA is inhibited by cycloheximide and actinomycin D suggesting that both agents increase enzyme activity by increasing gene transcription. Cycloheximide 77-90 ornithine decarboxylase 1 Rattus norvegicus 17-40 1280364-7 1992 Furthermore, bFGF was also able to stimulate ODC mRNA synthesis in the presence of cycloheximide. Cycloheximide 83-96 ornithine decarboxylase 1 Rattus norvegicus 45-48 2106270-5 1990 With the use of scraped intestinal mucosa from cycloheximide-treated rats, the time course of the decline in ODC activity yielded a half-life of approximately 22 min. Cycloheximide 47-60 ornithine decarboxylase 1 Rattus norvegicus 109-112 1889704-6 1991 When protein synthesis was blocked by addition of cycloheximide, ornithine decarboxylase mRNA levels remained unchanged in response to glucocorticoids, indicating a primary effect of dexamethasone. Cycloheximide 50-63 ornithine decarboxylase 1 Rattus norvegicus 65-88 2082182-4 1990 Addition of 25 micrograms/ml cycloheximide (CHX) to the testosterone-pretreated cells resulted in a loss of the testosterone-mediated decrease in ODC mRNA levels by 4 h. Surprisingly, a further 1.8-fold increase in ODC mRNA was observed at 8 h compared to that in untreated cells. Cycloheximide 29-42 ornithine decarboxylase 1 Rattus norvegicus 146-149 2082182-4 1990 Addition of 25 micrograms/ml cycloheximide (CHX) to the testosterone-pretreated cells resulted in a loss of the testosterone-mediated decrease in ODC mRNA levels by 4 h. Surprisingly, a further 1.8-fold increase in ODC mRNA was observed at 8 h compared to that in untreated cells. Cycloheximide 29-42 ornithine decarboxylase 1 Rattus norvegicus 215-218 2082182-4 1990 Addition of 25 micrograms/ml cycloheximide (CHX) to the testosterone-pretreated cells resulted in a loss of the testosterone-mediated decrease in ODC mRNA levels by 4 h. Surprisingly, a further 1.8-fold increase in ODC mRNA was observed at 8 h compared to that in untreated cells. Cycloheximide 44-47 ornithine decarboxylase 1 Rattus norvegicus 146-149 2082182-4 1990 Addition of 25 micrograms/ml cycloheximide (CHX) to the testosterone-pretreated cells resulted in a loss of the testosterone-mediated decrease in ODC mRNA levels by 4 h. Surprisingly, a further 1.8-fold increase in ODC mRNA was observed at 8 h compared to that in untreated cells. Cycloheximide 44-47 ornithine decarboxylase 1 Rattus norvegicus 215-218 2082182-7 1990 These results demonstrate that the mechanism by which testosterone decreases ODC mRNA levels requires continual protein synthesis, since the effect can be abolished by treating the cells with CHX or puromycin. Cycloheximide 192-195 ornithine decarboxylase 1 Rattus norvegicus 77-80 2554685-4 1989 Induction of ODC activity by PTH was partly inhibited by actinomycin D and cycloheximide, with 40 and 55% inhibition, respectively. Cycloheximide 75-88 ornithine decarboxylase 1 Rattus norvegicus 13-16 3341033-5 1988 The increases in ODC and heme oxygenase activities evoked by DEM were almost completely blocked by pretreatment of rats with either actinomycin D or cycloheximide. Cycloheximide 149-162 ornithine decarboxylase 1 Rattus norvegicus 17-20 3178765-6 1988 These results are consistent with the previous observation in HTC cells that the decay rate of ODC activity in the presence of cycloheximide correlated well with the proportion of ODC present as a complex with antizyme, suggesting the ubiquitous role of antizyme in ODC degradation. Cycloheximide 127-140 ornithine decarboxylase 1 Rattus norvegicus 95-98 2605669-5 1989 The two independently collected fractions of ODC peaks exhibited different affinity for pyridoxal 5"-phosphate in vitro and sensitivity to cycloheximide in vivo. Cycloheximide 139-152 ornithine decarboxylase 1 Rattus norvegicus 45-48 2491756-6 1989 Cycloheximide and actinomycin D were without effect on the early increase in ODC activity but inhibited the delayed increase in ODC activity, an observation suggesting that the initial increase in activity reflects an activation of a cryptic ODC via a posttranslational process, whereas the delayed increase in activity results from ODC synthesis mainly under transcriptional control. Cycloheximide 0-13 ornithine decarboxylase 1 Rattus norvegicus 128-131 2491756-6 1989 Cycloheximide and actinomycin D were without effect on the early increase in ODC activity but inhibited the delayed increase in ODC activity, an observation suggesting that the initial increase in activity reflects an activation of a cryptic ODC via a posttranslational process, whereas the delayed increase in activity results from ODC synthesis mainly under transcriptional control. Cycloheximide 0-13 ornithine decarboxylase 1 Rattus norvegicus 128-131 2491756-6 1989 Cycloheximide and actinomycin D were without effect on the early increase in ODC activity but inhibited the delayed increase in ODC activity, an observation suggesting that the initial increase in activity reflects an activation of a cryptic ODC via a posttranslational process, whereas the delayed increase in activity results from ODC synthesis mainly under transcriptional control. Cycloheximide 0-13 ornithine decarboxylase 1 Rattus norvegicus 128-131 2796592-6 1989 Pretreatment of rats with actinomycin D and cycloheximide almost completely blocked the BSP-mediated increase of ODC and SAMDC activities. Cycloheximide 44-57 ornithine decarboxylase 1 Rattus norvegicus 113-116 3621358-0 1987 Studies on ornithine decarboxylase from liver, kidney and tumoral tissues during activity decay following cycloheximide administration. Cycloheximide 106-119 ornithine decarboxylase 1 Rattus norvegicus 11-34 3632701-6 1987 Inhibition of protein synthesis by cycloheximide (10 micrograms/ml) led to a superinduction of ODC mRNA in the presence of TPA, which suggested that a short-lived protein may be responsible for negative control of ODC expression. Cycloheximide 35-48 ornithine decarboxylase 1 Rattus norvegicus 95-98 3632701-6 1987 Inhibition of protein synthesis by cycloheximide (10 micrograms/ml) led to a superinduction of ODC mRNA in the presence of TPA, which suggested that a short-lived protein may be responsible for negative control of ODC expression. Cycloheximide 35-48 ornithine decarboxylase 1 Rattus norvegicus 214-217 3754136-7 1986 The pretreatment of animals with either actinomycin D or cycloheximide almost completely blocked the Co2+-mediated increase of ODC activity. Cycloheximide 57-70 ornithine decarboxylase 1 Rattus norvegicus 127-130 3948865-5 1986 Addition of 10 mM putrescine caused a rapid decay of ODC activity, which was faster than ODC decay in the presence of cycloheximide. Cycloheximide 118-131 ornithine decarboxylase 1 Rattus norvegicus 89-92 6517942-5 1984 The increase of ornithine decarboxylase seen on the administration of cadmium was cancelled by pretreatment of rats with cycloheximide. Cycloheximide 121-134 ornithine decarboxylase 1 Rattus norvegicus 16-39 4039135-1 1985 A good correlation was observed between the reciprocal of the half-life of ornithine decarboxylase (ODC) activity in the presence of cycloheximide and the relative amount of ODC-antizyme complex to total ODC (free ODC plus complexed ODC) activity in HTC cells examined at various times after cell dilution or change of medium. Cycloheximide 133-146 ornithine decarboxylase 1 Rattus norvegicus 75-98 4039135-1 1985 A good correlation was observed between the reciprocal of the half-life of ornithine decarboxylase (ODC) activity in the presence of cycloheximide and the relative amount of ODC-antizyme complex to total ODC (free ODC plus complexed ODC) activity in HTC cells examined at various times after cell dilution or change of medium. Cycloheximide 133-146 ornithine decarboxylase 1 Rattus norvegicus 100-103 4039135-1 1985 A good correlation was observed between the reciprocal of the half-life of ornithine decarboxylase (ODC) activity in the presence of cycloheximide and the relative amount of ODC-antizyme complex to total ODC (free ODC plus complexed ODC) activity in HTC cells examined at various times after cell dilution or change of medium. Cycloheximide 133-146 ornithine decarboxylase 1 Rattus norvegicus 174-177 4039135-1 1985 A good correlation was observed between the reciprocal of the half-life of ornithine decarboxylase (ODC) activity in the presence of cycloheximide and the relative amount of ODC-antizyme complex to total ODC (free ODC plus complexed ODC) activity in HTC cells examined at various times after cell dilution or change of medium. Cycloheximide 133-146 ornithine decarboxylase 1 Rattus norvegicus 174-177 4039135-1 1985 A good correlation was observed between the reciprocal of the half-life of ornithine decarboxylase (ODC) activity in the presence of cycloheximide and the relative amount of ODC-antizyme complex to total ODC (free ODC plus complexed ODC) activity in HTC cells examined at various times after cell dilution or change of medium. Cycloheximide 133-146 ornithine decarboxylase 1 Rattus norvegicus 174-177 4039135-1 1985 A good correlation was observed between the reciprocal of the half-life of ornithine decarboxylase (ODC) activity in the presence of cycloheximide and the relative amount of ODC-antizyme complex to total ODC (free ODC plus complexed ODC) activity in HTC cells examined at various times after cell dilution or change of medium. Cycloheximide 133-146 ornithine decarboxylase 1 Rattus norvegicus 174-177 4072800-13 1985 Decay of total ODC activity (free plus complexed ODC) was more rapid with putrescine than with cycloheximide. Cycloheximide 95-108 ornithine decarboxylase 1 Rattus norvegicus 15-18 4072800-13 1985 Decay of total ODC activity (free plus complexed ODC) was more rapid with putrescine than with cycloheximide. Cycloheximide 95-108 ornithine decarboxylase 1 Rattus norvegicus 49-52 7109827-6 1982 Pretreatment of the animals with either cycloheximide or actinomycin D delayed the onset of ODC induction. Cycloheximide 40-53 ornithine decarboxylase 1 Rattus norvegicus 92-95 6432060-4 1984 EGTA appeared to inhibit the synthesis of ornithine decarboxylase, because the half-life values of ornithine decarboxylase activity were similar (37-47 min) in the presence of EGTA or protein synthesis inhibitors such as cycloheximide or emetine. Cycloheximide 221-234 ornithine decarboxylase 1 Rattus norvegicus 42-65 6432060-5 1984 Also, calcium readdition rapidly reversed EGTA inhibition of ornithine decarboxylase activity by a mechanism which could be blocked by cycloheximide. Cycloheximide 135-148 ornithine decarboxylase 1 Rattus norvegicus 61-84 6744241-7 1984 Pretreatment of the animals either with actinomycin D or with cycloheximide completely blocked anthralin mediated ODC induction suggesting that de novo ODC-mRNA synthesis and subsequent translation is involved in this process. Cycloheximide 62-75 ornithine decarboxylase 1 Rattus norvegicus 114-117 6744241-7 1984 Pretreatment of the animals either with actinomycin D or with cycloheximide completely blocked anthralin mediated ODC induction suggesting that de novo ODC-mRNA synthesis and subsequent translation is involved in this process. Cycloheximide 62-75 ornithine decarboxylase 1 Rattus norvegicus 152-155 6852208-6 1983 The tryptophan-induced stimulation of hepatic ODC activity was not affected by prior adrenalectomy but was abolished by pretreatment with cycloheximide. Cycloheximide 138-151 ornithine decarboxylase 1 Rattus norvegicus 46-49 6405745-2 1983 Although luteinizing hormone enhanced both ornithine decarboxylase activity and testosterone production at a similar physiological dose range, we found dissociation in the two responses in terms of their temporal aspect and the way they were affected by an irreversible inhibitor of ornithine decarboxylase, alpha-difluoromethylornithine, and protein synthesis inhibitor cycloheximide. Cycloheximide 371-384 ornithine decarboxylase 1 Rattus norvegicus 283-306 7394309-5 1980 The induction of ornithine decarboxylase activity by nafenopin, as well as the potentiating effect of phentolamine was inhibited by 1,3-diaminopropane and cycloheximide, implying a requirement for synthesis of new enzyme protein for both effects. Cycloheximide 155-168 ornithine decarboxylase 1 Rattus norvegicus 17-40 7339299-7 1981 Both ornithine decarboxylase and spermidine N1-acetyltransferase turn over rapidly as indicated by the loss of activity in response to cycloheximide. Cycloheximide 135-148 ornithine decarboxylase 1 Rattus norvegicus 5-28 7285867-3 1981 During cycloheximide-maintained inhibition of protein synthesis, the rate of inactivation of ventral prostate L-ornithine decarboxylase (ODC) or S-adenosyl-L-methionine decarboxylase (AMDC) activity and dorsolateral prostate AMDC activity was comparable in the prostates of young and aged AXC rats. Cycloheximide 7-20 ornithine decarboxylase 1 Rattus norvegicus 110-135 7326828-7 1981 The in vivo induction of rat liver ODC activity by TPA appeared to be under transcriptional control since administration of 2 mg actinomycin D/kg body weight or 50 mg cycloheximide/kg body weight 1 h prior to application of the tumor promotor prevented the increase of ODC activity. Cycloheximide 167-180 ornithine decarboxylase 1 Rattus norvegicus 35-38 7326828-7 1981 The in vivo induction of rat liver ODC activity by TPA appeared to be under transcriptional control since administration of 2 mg actinomycin D/kg body weight or 50 mg cycloheximide/kg body weight 1 h prior to application of the tumor promotor prevented the increase of ODC activity. Cycloheximide 167-180 ornithine decarboxylase 1 Rattus norvegicus 269-272 6113605-6 1980 When the half-lives of ODC and TAT were measured 24 hr after partial hepatectomy by using cycloheximide, it appeared that ethanol caused a significant stabilization of both enzymes. Cycloheximide 90-103 ornithine decarboxylase 1 Rattus norvegicus 23-26 30718-4 1978 The increase in ODC activity was suppressed by treatment with cycloheximide (50 mg/kg) and dactinomycin, 500 microgram/rat, confirming that the enzyme response reflects protein synthesis. Cycloheximide 62-75 ornithine decarboxylase 1 Rattus norvegicus 16-19 486492-5 1979 Lysine and ornithine decarboxylase activities were lost to similar extents on inhibition of protein synthesis by cycloheximide and on exposure to alpha-difluoromethylornithine. Cycloheximide 113-126 ornithine decarboxylase 1 Rattus norvegicus 11-34 426782-11 1979 A single injection of diaminopropane produced an extremely rapid decay of liver ornithine decarboxylase activity (half-life about 12min), which was comparable with, or swifter than, that induced by cycloheximide. Cycloheximide 198-211 ornithine decarboxylase 1 Rattus norvegicus 80-103 426782-12 1979 However, although after cycloheximide treatment the amount of immunotitrable ornithine decarboxylase decreased only slightly more slowly than the enzyme activity, diaminopropane injection did not decrease the amount of the immunoreactive protein, but, on the contrary, invariably caused a marked increase in the apparent amount of antigen, after some lag period. Cycloheximide 24-37 ornithine decarboxylase 1 Rattus norvegicus 77-100 200929-3 1977 The nerve growth factor-mediated increase in ornithine decarboxylase activity in vitro can be prevented by the addition of cycloheximide, actinomycin D, or antibody to nerve growth factor. Cycloheximide 123-136 ornithine decarboxylase 1 Rattus norvegicus 45-68 194994-2 1977 Actinomycin D, or cycloheximide, completely prevented an increase in ODC when given with PMSG, but only cycloheximide lowered the enzyme activity when given 18 h later. Cycloheximide 18-31 ornithine decarboxylase 1 Rattus norvegicus 69-72 826178-3 1976 The rise in ornithine decarboxylase is reduced by actinomycin D or cycloheximide. Cycloheximide 67-80 ornithine decarboxylase 1 Rattus norvegicus 12-35 842265-5 1977 Cycloheximide caused a rapid decay of the activity of liver ornithine decarboxylase (half-life 15 min) and also a decay of the activity of adenosylmethionine decarboxylase (half-life 36 min). Cycloheximide 0-13 ornithine decarboxylase 1 Rattus norvegicus 60-83 165059-7 1975 Little TSH effect was noted before 3 h. Maximal ODC activity occurred between 4 and 5 h. The TSH stimulation of ODC could be inhibited by pretreatment with actinomycin D or cycloheximide, suggesting that the increase in ODC activity requires new RNA and protein synthesis. Cycloheximide 173-186 ornithine decarboxylase 1 Rattus norvegicus 112-115 171142-8 1975 Stimulation of ODC activity was 90% inhibited by the intraperitoneal administration of actinomycin D (80 mug/100 g body wt) or cycloheximide (400 mug/100 g body wt) given simultaneously with TSH. Cycloheximide 127-140 ornithine decarboxylase 1 Rattus norvegicus 15-18 809057-4 1975 In addition, the rapid decay in ornithine decarboxylase activity in regenerating rat liver after cycloheximide injection is accompanied by a decrease in the immunoreactive protein. Cycloheximide 97-110 ornithine decarboxylase 1 Rattus norvegicus 32-55 165059-7 1975 Little TSH effect was noted before 3 h. Maximal ODC activity occurred between 4 and 5 h. The TSH stimulation of ODC could be inhibited by pretreatment with actinomycin D or cycloheximide, suggesting that the increase in ODC activity requires new RNA and protein synthesis. Cycloheximide 173-186 ornithine decarboxylase 1 Rattus norvegicus 48-51 165059-7 1975 Little TSH effect was noted before 3 h. Maximal ODC activity occurred between 4 and 5 h. The TSH stimulation of ODC could be inhibited by pretreatment with actinomycin D or cycloheximide, suggesting that the increase in ODC activity requires new RNA and protein synthesis. Cycloheximide 173-186 ornithine decarboxylase 1 Rattus norvegicus 112-115 806079-0 1975 Nature of the increase in renal ornithine decarboxylase activity after cycloheximide administration in the rat. Cycloheximide 71-84 ornithine decarboxylase 1 Rattus norvegicus 32-55 806079-1 1975 The present study was designed to determine whether the increase in rat renal ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) activity after cycloheximide administration was a primary effect on the kidney or was a secondary effect of adrenal or pituitary hormones released in response to the drug. Cycloheximide 158-171 ornithine decarboxylase 1 Rattus norvegicus 78-101 806079-2 1975 Renal ornithine decarboxylase activity was reduced approximately 70% 1 hr after intraperitoneal administration of doses of cycloheximide that also inhibited renal protein synthesis by 68-95% within 1 hr. Cycloheximide 123-136 ornithine decarboxylase 1 Rattus norvegicus 6-29 806079-4 1975 Peak ornithine decarboxylase activity was directly proportional to cycloheximide doses up to 250 mug; larger doses, which almost abolished protein synthesis for 8 hr, where inhibitory. Cycloheximide 67-80 ornithine decarboxylase 1 Rattus norvegicus 5-28 4352578-10 1973 In addition, actinomycin D or cycloheximide in doses sufficient to block adrenal RNA and protein synthesis, respectively inhibited the stimulation of ornithine decarboxylase activity by ACTH in vivo. Cycloheximide 30-43 ornithine decarboxylase 1 Rattus norvegicus 150-173