PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
5283959-1	1971	Previous studies have shown that the vitamin K-induced synthesis of prothrombin in a vitamin K-deficient rat is only slightly inhibited by cycloheximide treatment.	Cycloheximide	139-152	coagulation factor II	Rattus norvegicus	68-79	
1661096-9	1991	The addition of cycloheximide to smooth muscle cells during their incubation with IL-1 beta completely inhibited smooth muscle cell nitrite production, the effects of the smooth muscle cells on platelet cGMP levels, and platelet responses to thrombin.	Cycloheximide	16-29	coagulation factor II	Rattus norvegicus	242-250	
5437347-0	1970	Reversal by vitamin K of cycloheximide inhibited biosynthesis of prothrombin in the isolated perfused rat liver.	Cycloheximide	25-38	coagulation factor II	Rattus norvegicus	65-76	
15281096-9	2004	Pre-treatment of smooth muscle cells with cycloheximide abolished the reduction of PN-1 expression by thrombin.	Cycloheximide	42-55	coagulation factor II	Rattus norvegicus	102-110	
9182610-6	1997	The thrombin-mediated increase in NGF secretion was prevented by actinomycin D and cycloheximide, suggesting that RNA transcription and protein synthesis are required.	Cycloheximide	83-96	coagulation factor II	Rattus norvegicus	4-12	
5283959-3	1971	When cycloheximide (5 mg/kg) was given to vitamin K-deficient rats 30 min before vitamin K, about 70% of the amount of prothrombin seen in rats not treated with cycloheximide was produced (two-stage assay), and the prothrombin band could be seen on the electrophoretic gels.	Cycloheximide	5-18	coagulation factor II	Rattus norvegicus	119-130	
5283959-3	1971	When cycloheximide (5 mg/kg) was given to vitamin K-deficient rats 30 min before vitamin K, about 70% of the amount of prothrombin seen in rats not treated with cycloheximide was produced (two-stage assay), and the prothrombin band could be seen on the electrophoretic gels.	Cycloheximide	5-18	coagulation factor II	Rattus norvegicus	215-226	
5283959-4	1971	However, if radioactive amino acids are administered to the rats after cycloheximide treatment, the newly formed prothrombin contains no radioactivity.	Cycloheximide	71-84	coagulation factor II	Rattus norvegicus	113-124	
5283959-5	1971	The isolated prothrombin does contain radioactivity if the vitamin K-deficient rats are treated with vitamin K but no cycloheximide.	Cycloheximide	118-131	coagulation factor II	Rattus norvegicus	13-24	
19878520-6	2010	Thrombin (2.5 U/mL) induced an increase in immunoreactive ET-1 expression, which was inhibited by cycloheximide (10 microg/mL), and an increase in preproET-1 mRNA expression, as assessed by reverse transcription polymerase chain reaction.	Cycloheximide	98-111	coagulation factor II	Rattus norvegicus	0-8	
17498698-5	2007	Intracerebroventricular injection of argatroban or cycloheximide, both of which prevent thrombin cytotoxicity in vitro, exhibited a significant neuroprotective effect against ICH-induced injury.	Cycloheximide	51-64	coagulation factor II	Rattus norvegicus	88-96