PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19563893-5	2009	Cycloheximide inhibits stimulation at the mRNA level, suggesting that progestin induction of MnSOD mRNA depends on synthesis of protein.	Cycloheximide	0-13	superoxide dismutase 2	Homo sapiens	93-98	
15118344-4	2004	In Hela cells, the induction of Mn-SOD mRNA by YS 51 was in a time- and dose-dependent manner and the expression of Mn-SOD mRNA was increased to a maximum of 4-fold in 9 h. Enhancement of Mn-SOD mRNA by YS 51 was completely abolished by actinomycin D but not cycloheximide, suggesting that the induction of Mn-SOD mRNA byYS 51 is independent of new protein synthesis.	Cycloheximide	259-272	superoxide dismutase 2	Homo sapiens	32-38	
17157182-5	2006	In the presence of cycloheximide, an inhibitor of protein synthesis, the rates of cell death and MnSOD degradation were accelerated.	Cycloheximide	19-32	superoxide dismutase 2	Homo sapiens	97-102	
15330761-3	2004	Pre-treatment with CHX (cycloheximide) followed by PMA led to significantly higher levels of MnSOD mRNA compared with those with either agent alone, suggesting de novo synthesis of an inhibitory protein.	Cycloheximide	19-22	superoxide dismutase 2	Homo sapiens	93-98	
15330761-3	2004	Pre-treatment with CHX (cycloheximide) followed by PMA led to significantly higher levels of MnSOD mRNA compared with those with either agent alone, suggesting de novo synthesis of an inhibitory protein.	Cycloheximide	24-37	superoxide dismutase 2	Homo sapiens	93-98	
15118344-4	2004	In Hela cells, the induction of Mn-SOD mRNA by YS 51 was in a time- and dose-dependent manner and the expression of Mn-SOD mRNA was increased to a maximum of 4-fold in 9 h. Enhancement of Mn-SOD mRNA by YS 51 was completely abolished by actinomycin D but not cycloheximide, suggesting that the induction of Mn-SOD mRNA byYS 51 is independent of new protein synthesis.	Cycloheximide	259-272	superoxide dismutase 2	Homo sapiens	116-122	
15118344-4	2004	In Hela cells, the induction of Mn-SOD mRNA by YS 51 was in a time- and dose-dependent manner and the expression of Mn-SOD mRNA was increased to a maximum of 4-fold in 9 h. Enhancement of Mn-SOD mRNA by YS 51 was completely abolished by actinomycin D but not cycloheximide, suggesting that the induction of Mn-SOD mRNA byYS 51 is independent of new protein synthesis.	Cycloheximide	259-272	superoxide dismutase 2	Homo sapiens	116-122	
15118344-4	2004	In Hela cells, the induction of Mn-SOD mRNA by YS 51 was in a time- and dose-dependent manner and the expression of Mn-SOD mRNA was increased to a maximum of 4-fold in 9 h. Enhancement of Mn-SOD mRNA by YS 51 was completely abolished by actinomycin D but not cycloheximide, suggesting that the induction of Mn-SOD mRNA byYS 51 is independent of new protein synthesis.	Cycloheximide	259-272	superoxide dismutase 2	Homo sapiens	116-122	
8903482-6	1996	Pre-treatment with either actinomycin D or cycloheximide inhibited the induction of MnSOD mRNA by OK432.	Cycloheximide	43-56	superoxide dismutase 2	Homo sapiens	84-89	
2058689-4	1991	The induction of Mn SOD by LPS was blocked by both a RNA synthesis inhibitor, actinomycin D, and a protein synthesis inhibitor, cycloheximide.	Cycloheximide	128-141	superoxide dismutase 2	Homo sapiens	17-23	
1313774-3	1992	The purpose of this study was to establish whether MnSOD was increased in cells selected for resistance to cytolysis by TNF in combination with cycloheximide.	Cycloheximide	144-157	superoxide dismutase 2	Homo sapiens	51-56	
1761541-10	1991	Induction of MnSOD gene expression was prevented by addition of actinomycin D and cycloheximide.	Cycloheximide	82-95	superoxide dismutase 2	Homo sapiens	13-18	
8037686-6	1994	When the effect of cycloheximide on the decay of Mn-SOD mRNA was examined by inhibiting mRNA synthesis with actinomycin D, cycloheximide had virtually no effect on mRNA stability, suggesting that accumulation of the mRNA was caused by activation by this reagent of transcription of the gene.	Cycloheximide	19-32	superoxide dismutase 2	Homo sapiens	49-55	
8037686-7	1994	PMA pretreatment of HeLa cells markedly enhanced cycloheximide-dependent superinduction of Mn-SOD mRNA.	Cycloheximide	49-62	superoxide dismutase 2	Homo sapiens	91-97	
2476237-3	1989	Overexpression of MnSOD confers increased resistance to TNF plus cycloheximide on the 293 human embryonic kidney cell line.	Cycloheximide	65-78	superoxide dismutase 2	Homo sapiens	18-23	
2476237-4	1989	Conversely, expression of antisense MnSOD RNA renders these cells sensitive to TNF even in the absence of cycloheximide.	Cycloheximide	106-119	superoxide dismutase 2	Homo sapiens	36-41