PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16034134-5 2005 We found that porcine EC incubated with IL-4 or IL-13, but not with IL-10 or IL-11, became protected from killing by complement and apoptosis induced by TNF-alpha plus cycloheximide. Cycloheximide 168-181 interleukin 4 Homo sapiens 40-44 18005266-8 2008 Utilization of catalase, cycloheximide and genistein inhibitors showed that IL-4 induced SOCS3 by a mechanism dependent on a complete NADPH oxidase complex, protein synthesis and tyrosine phosphorylation, but independent of production of reactive oxygen species. Cycloheximide 25-38 interleukin 4 Homo sapiens 76-80 16087364-8 2005 IL-4 and IL-13 potentiated CHX-induced apoptosis in basal cells but not in columnar cells, possibly due to low levels of the IL-4 receptor. Cycloheximide 27-30 interleukin 4 Homo sapiens 0-4 17264307-9 2007 The effect of IL-4 on SOCS3 protein expression was increased markedly when the proteasome inhibitor MG132 was added to the cultures, but this was inhibited by cycloheximide, suggesting that SOCS3 is de novo-synthesized in response to IL-4. Cycloheximide 159-172 interleukin 4 Homo sapiens 14-18 17264307-9 2007 The effect of IL-4 on SOCS3 protein expression was increased markedly when the proteasome inhibitor MG132 was added to the cultures, but this was inhibited by cycloheximide, suggesting that SOCS3 is de novo-synthesized in response to IL-4. Cycloheximide 159-172 interleukin 4 Homo sapiens 234-238 15863444-7 2005 Cycloheximide and actinomycin D abrogated IL-4- and IL-13-dependent CCL26 but not CCL24 secretion. Cycloheximide 0-13 interleukin 4 Homo sapiens 42-57 10222064-5 1999 Cycloheximide (protein synthesis inhibitor), tunicamycin (N-linked glycosylation inhibitor), and beta-d-xyloside (chondroitin sulfation inhibitor) all inhibited IL-4-mediated downregulation of TNFalpha-induced monocyte HA binding. Cycloheximide 0-13 interleukin 4 Homo sapiens 161-165 9737666-8 1998 Actinomycin D, cycloheximide, and brefeldin A inhibited the increase in DAF release induced by IL-4 and IL-1beta stimulation. Cycloheximide 15-28 interleukin 4 Homo sapiens 95-99 9509417-5 1997 Activation of this factor, named NF-IL-4/CD23, occurred within 5 min after IL-4 treatment in a cycloheximide-insensitive manner. Cycloheximide 95-108 interleukin 4 Homo sapiens 36-40 9250823-4 1997 Inhibition of protein synthesis with cycloheximide (CXM) had no effect on the expression of CD21 molecules, but abrogated their down-regulation by IL4, suggesting that IL4 induced the synthesis of proteins which modify the processing of CD21 molecules. Cycloheximide 37-50 interleukin 4 Homo sapiens 147-150 9250823-4 1997 Inhibition of protein synthesis with cycloheximide (CXM) had no effect on the expression of CD21 molecules, but abrogated their down-regulation by IL4, suggesting that IL4 induced the synthesis of proteins which modify the processing of CD21 molecules. Cycloheximide 37-50 interleukin 4 Homo sapiens 168-171 9250823-4 1997 Inhibition of protein synthesis with cycloheximide (CXM) had no effect on the expression of CD21 molecules, but abrogated their down-regulation by IL4, suggesting that IL4 induced the synthesis of proteins which modify the processing of CD21 molecules. Cycloheximide 52-55 interleukin 4 Homo sapiens 147-150 9250823-4 1997 Inhibition of protein synthesis with cycloheximide (CXM) had no effect on the expression of CD21 molecules, but abrogated their down-regulation by IL4, suggesting that IL4 induced the synthesis of proteins which modify the processing of CD21 molecules. Cycloheximide 52-55 interleukin 4 Homo sapiens 168-171 8871604-3 1996 The inhibition of protein synthesis with cycloheximide (CXM) diminished the down-regulation of CD38 induced by IL4. Cycloheximide 41-54 interleukin 4 Homo sapiens 111-114 8941674-7 1996 Cycloheximide increased basal TN mRNA expression and induced TN mRNA in IL-4-treated fibroblasts, suggesting that repressor protein(s) may regulate transcription of the TN gene. Cycloheximide 0-13 interleukin 4 Homo sapiens 72-76 8871604-3 1996 The inhibition of protein synthesis with cycloheximide (CXM) diminished the down-regulation of CD38 induced by IL4. Cycloheximide 56-59 interleukin 4 Homo sapiens 111-114 7780157-7 1995 Moreover, the addition of cycloheximide (CHX) to LPS-stimulated monocytes resulted in a superinduction of COX-2 mRNA, whereas CHX almost abrogated the abilities of IL-10 and IL-4 to inhibit this gene expression. Cycloheximide 26-39 interleukin 4 Homo sapiens 174-178 7780157-7 1995 Moreover, the addition of cycloheximide (CHX) to LPS-stimulated monocytes resulted in a superinduction of COX-2 mRNA, whereas CHX almost abrogated the abilities of IL-10 and IL-4 to inhibit this gene expression. Cycloheximide 41-44 interleukin 4 Homo sapiens 174-178 8144899-10 1994 IL-4 secretion was slower (t1/2 of 1.5 h) than histamine release and was inhibited by cycloheximide. Cycloheximide 86-99 interleukin 4 Homo sapiens 0-4 8406799-6 1993 When protein synthesis of MP-stimulated PBMC was inhibited by cycloheximide, a superinduction of mRNAs for IL-4 and IL-10 and, more markedly, gamma interferon was observed. Cycloheximide 62-75 interleukin 4 Homo sapiens 107-111 2026872-5 1991 The initial 2 to 3 h lag period may be necessary for production of a protein(s) that mediates this inhibitory effect because treatment with the protein synthesis inhibitor, cycloheximide, blocked the marked reduction of IL-1 message levels induced by IL-4. Cycloheximide 173-186 interleukin 4 Homo sapiens 251-255 8417800-12 1993 Furthermore, it appeared that the induction of IL-4 mRNA was dependent on protein synthesis because cycloheximide (CHX) blocked the Con A- and Con A+PMA-induced expression of IL-4 mRNA. Cycloheximide 100-113 interleukin 4 Homo sapiens 47-51 8417800-12 1993 Furthermore, it appeared that the induction of IL-4 mRNA was dependent on protein synthesis because cycloheximide (CHX) blocked the Con A- and Con A+PMA-induced expression of IL-4 mRNA. Cycloheximide 100-113 interleukin 4 Homo sapiens 175-179 8417800-12 1993 Furthermore, it appeared that the induction of IL-4 mRNA was dependent on protein synthesis because cycloheximide (CHX) blocked the Con A- and Con A+PMA-induced expression of IL-4 mRNA. Cycloheximide 115-118 interleukin 4 Homo sapiens 47-51 8417800-12 1993 Furthermore, it appeared that the induction of IL-4 mRNA was dependent on protein synthesis because cycloheximide (CHX) blocked the Con A- and Con A+PMA-induced expression of IL-4 mRNA. Cycloheximide 115-118 interleukin 4 Homo sapiens 175-179 1617647-8 1992 Cycloheximide inhibited the expression of IL-4 receptors by 50% in about 2 h in both cell types indicating both the half-life of IL-4 receptors and the requirement for protein synthesis for the tat III up-regulation of IL-4 receptors. Cycloheximide 0-13 interleukin 4 Homo sapiens 42-46 1617647-8 1992 Cycloheximide inhibited the expression of IL-4 receptors by 50% in about 2 h in both cell types indicating both the half-life of IL-4 receptors and the requirement for protein synthesis for the tat III up-regulation of IL-4 receptors. Cycloheximide 0-13 interleukin 4 Homo sapiens 129-133 1617647-8 1992 Cycloheximide inhibited the expression of IL-4 receptors by 50% in about 2 h in both cell types indicating both the half-life of IL-4 receptors and the requirement for protein synthesis for the tat III up-regulation of IL-4 receptors. Cycloheximide 0-13 interleukin 4 Homo sapiens 129-133 1571090-4 1992 The suppressive effects of IL-4 appear to be dependent upon de novo protein synthesis, as cycloheximide abrogated the IL-4-induced reduction in TNF-alpha mRNA levels from PBM. Cycloheximide 90-103 interleukin 4 Homo sapiens 27-31 1571090-4 1992 The suppressive effects of IL-4 appear to be dependent upon de novo protein synthesis, as cycloheximide abrogated the IL-4-induced reduction in TNF-alpha mRNA levels from PBM. Cycloheximide 90-103 interleukin 4 Homo sapiens 118-122 2026872-9 1991 In addition, the kinetics of inhibition and the fact that cycloheximide blocks this process suggest that IL-4 induces or enhances synthesis of a protein(s) that mediates these effects. Cycloheximide 58-71 interleukin 4 Homo sapiens 105-109 2200823-7 1990 The IL-4-induced inhibition of IL-8 mRNA expression was dependent on protein synthesis, as the suppressive effects of IL-4 were significantly negated by the addition of cycloheximide. Cycloheximide 169-182 interleukin 4 Homo sapiens 4-8 2200823-7 1990 The IL-4-induced inhibition of IL-8 mRNA expression was dependent on protein synthesis, as the suppressive effects of IL-4 were significantly negated by the addition of cycloheximide. Cycloheximide 169-182 interleukin 4 Homo sapiens 118-122 2965726-11 1988 The induction of CD23 and class II MHC Ag by IL-4 required intact protein synthesis as shown by its inhibition by cycloheximide. Cycloheximide 114-127 interleukin 4 Homo sapiens 45-49