PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27109480-7 2016 Both CQ and AQ elevated the transcription level of p21 though the activation of p53, but also blocked p21 protein degradation in the presence of cycloheximide, causing p21 protein accumulation mainly in the nucleus. Cycloheximide 145-158 cyclin dependent kinase inhibitor 1A Homo sapiens 102-105 27109480-7 2016 Both CQ and AQ elevated the transcription level of p21 though the activation of p53, but also blocked p21 protein degradation in the presence of cycloheximide, causing p21 protein accumulation mainly in the nucleus. Cycloheximide 145-158 cyclin dependent kinase inhibitor 1A Homo sapiens 102-105 18721791-5 2008 Cycloheximide decreased the basal p21 level, which was inhibited by CC treatment, supporting the stabilization of p21 by CC. Cycloheximide 0-13 cyclin dependent kinase inhibitor 1A Homo sapiens 34-37 18721791-5 2008 Cycloheximide decreased the basal p21 level, which was inhibited by CC treatment, supporting the stabilization of p21 by CC. Cycloheximide 0-13 cyclin dependent kinase inhibitor 1A Homo sapiens 114-117 11521188-0 2001 Identification of p21 as a target of cycloheximide-mediated facilitation of CD95-mediated apoptosis in human malignant glioma cells. Cycloheximide 37-50 cyclin dependent kinase inhibitor 1A Homo sapiens 18-21 17627285-6 2007 Inhibition of p21(Cip1/Waf1) protein synthesis with cyclohexamide (CHX) or silencing of p21(Cip1/Waf1) with siRNA, prevented ceramide-mediated G(2) arrest and the late induction of apoptosis. Cycloheximide 67-70 cyclin dependent kinase inhibitor 1A Homo sapiens 14-17 17627285-6 2007 Inhibition of p21(Cip1/Waf1) protein synthesis with cyclohexamide (CHX) or silencing of p21(Cip1/Waf1) with siRNA, prevented ceramide-mediated G(2) arrest and the late induction of apoptosis. Cycloheximide 67-70 cyclin dependent kinase inhibitor 1A Homo sapiens 18-22 12690110-4 2003 The up-regulation of p21Cip1 transcription is prevented by cycloheximide, indicating the requirement of intermediate protein(s), which, in turn, regulate gene expression. Cycloheximide 59-72 cyclin dependent kinase inhibitor 1A Homo sapiens 21-28 12396717-6 2002 Conversely, cotreatment of cells with a protein synthesis inhibitor, cycloheximide, and H(2)O(2) drastically shortened the half-life of p21. Cycloheximide 69-82 cyclin dependent kinase inhibitor 1A Homo sapiens 136-139 15961274-6 2006 Finally, our experiments utilizing cycloheximide prompt the suggestion that the stability of mRNA or protein also contributes to As2O3- or EGF-induced p21 expression. Cycloheximide 35-48 cyclin dependent kinase inhibitor 1A Homo sapiens 151-154 12869419-10 2003 Our experiments demonstrated: (i) that the elevated WAF1 mRNA expression after Fe chelation was due to increased transcription and also to a post-transcriptional mechanism that was sensitive to cycloheximide; and (ii) that Fe-chelation increased WAF1 expression through a p53-independent pathway. Cycloheximide 194-207 cyclin dependent kinase inhibitor 1A Homo sapiens 52-56 12054658-9 2002 Cycloheximide prevented the OxLDL-induced increase in p21, Rb, and HypoP-Rb, whereas okadaic acid had no effect. Cycloheximide 0-13 cyclin dependent kinase inhibitor 1A Homo sapiens 54-57 11786386-6 2002 Up-regulation of p21 was resistant to cycloheximide but not to actinomycin D, suggesting that it occurred at the transcriptional level. Cycloheximide 38-51 cyclin dependent kinase inhibitor 1A Homo sapiens 17-20 11521188-9 2001 These data place potentiating effects of CHX (i) to the activation of caspase 8 at the receptor in LN-229 cells as well as (ii) to a down-stream target at least in LN-18 cells, but probably both cell lines, that may be identical with p21Waf/Cip1. Cycloheximide 41-44 cyclin dependent kinase inhibitor 1A Homo sapiens 241-245 8878553-5 1996 Inhibition of protein synthesis by cycloheximide demonstrated increased p21 protein half-life in the presence of LC in mutant p53 containing cells. Cycloheximide 35-48 cyclin dependent kinase inhibitor 1A Homo sapiens 72-75 10441511-5 1999 In addition, in EoL-1 cells, p21 protein was induced by troglitazone treatment and the induction was inhibited by protein synthesis inhibitor, cycloheximide. Cycloheximide 143-156 cyclin dependent kinase inhibitor 1A Homo sapiens 29-32 11097743-4 2000 Further experiments suggested that cycloheximide (CHX), a protein synthesis inhibitor, increased the levels of p21(WAF1)mRNA and the induction of p21(WAF1)mRNA by TNF-alpha did not require new protein synthesis. Cycloheximide 35-48 cyclin dependent kinase inhibitor 1A Homo sapiens 111-114 11097743-4 2000 Further experiments suggested that cycloheximide (CHX), a protein synthesis inhibitor, increased the levels of p21(WAF1)mRNA and the induction of p21(WAF1)mRNA by TNF-alpha did not require new protein synthesis. Cycloheximide 35-48 cyclin dependent kinase inhibitor 1A Homo sapiens 115-119 11097743-4 2000 Further experiments suggested that cycloheximide (CHX), a protein synthesis inhibitor, increased the levels of p21(WAF1)mRNA and the induction of p21(WAF1)mRNA by TNF-alpha did not require new protein synthesis. Cycloheximide 35-48 cyclin dependent kinase inhibitor 1A Homo sapiens 146-149 11097743-4 2000 Further experiments suggested that cycloheximide (CHX), a protein synthesis inhibitor, increased the levels of p21(WAF1)mRNA and the induction of p21(WAF1)mRNA by TNF-alpha did not require new protein synthesis. Cycloheximide 35-48 cyclin dependent kinase inhibitor 1A Homo sapiens 150-154 11097743-4 2000 Further experiments suggested that cycloheximide (CHX), a protein synthesis inhibitor, increased the levels of p21(WAF1)mRNA and the induction of p21(WAF1)mRNA by TNF-alpha did not require new protein synthesis. Cycloheximide 50-53 cyclin dependent kinase inhibitor 1A Homo sapiens 111-114 11097743-4 2000 Further experiments suggested that cycloheximide (CHX), a protein synthesis inhibitor, increased the levels of p21(WAF1)mRNA and the induction of p21(WAF1)mRNA by TNF-alpha did not require new protein synthesis. Cycloheximide 50-53 cyclin dependent kinase inhibitor 1A Homo sapiens 115-119 11097743-4 2000 Further experiments suggested that cycloheximide (CHX), a protein synthesis inhibitor, increased the levels of p21(WAF1)mRNA and the induction of p21(WAF1)mRNA by TNF-alpha did not require new protein synthesis. Cycloheximide 50-53 cyclin dependent kinase inhibitor 1A Homo sapiens 146-149 11097743-4 2000 Further experiments suggested that cycloheximide (CHX), a protein synthesis inhibitor, increased the levels of p21(WAF1)mRNA and the induction of p21(WAF1)mRNA by TNF-alpha did not require new protein synthesis. Cycloheximide 50-53 cyclin dependent kinase inhibitor 1A Homo sapiens 150-154 9895307-4 1999 The increase in p21/CIP1 mRNA upon addition of EGF was rapid, and was enhanced in the presence of cycloheximide. Cycloheximide 98-111 cyclin dependent kinase inhibitor 1A Homo sapiens 16-19 9895307-4 1999 The increase in p21/CIP1 mRNA upon addition of EGF was rapid, and was enhanced in the presence of cycloheximide. Cycloheximide 98-111 cyclin dependent kinase inhibitor 1A Homo sapiens 20-24 9049198-7 1997 Inhibition of protein synthesis with cycloheximide rapidly induced p21 expression, primarily by post-transcriptional stabilization of the transcript. Cycloheximide 37-50 cyclin dependent kinase inhibitor 1A Homo sapiens 67-70 8846917-8 1996 Protein synthesis inhibition by cycloheximide (CHX) treatment indicated that the half-life of p21/SDI-1 in dividing HT1 cells was approximately 30 min. Cycloheximide 32-45 cyclin dependent kinase inhibitor 1A Homo sapiens 94-97 8846917-8 1996 Protein synthesis inhibition by cycloheximide (CHX) treatment indicated that the half-life of p21/SDI-1 in dividing HT1 cells was approximately 30 min. Cycloheximide 32-45 cyclin dependent kinase inhibitor 1A Homo sapiens 98-103 8846917-8 1996 Protein synthesis inhibition by cycloheximide (CHX) treatment indicated that the half-life of p21/SDI-1 in dividing HT1 cells was approximately 30 min. Cycloheximide 47-50 cyclin dependent kinase inhibitor 1A Homo sapiens 94-97 8846917-8 1996 Protein synthesis inhibition by cycloheximide (CHX) treatment indicated that the half-life of p21/SDI-1 in dividing HT1 cells was approximately 30 min. Cycloheximide 47-50 cyclin dependent kinase inhibitor 1A Homo sapiens 98-103