PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15371131-4 2004 RESULTS: The protein synthesis inhibitor cycloheximide (10 microM) blocked both LPS-induced nitrite formation and iNOS protein expression in LSMC. Cycloheximide 41-54 nitric oxide synthase 2 Rattus norvegicus 114-118 10362664-5 1999 CX markedly attenuated the loss in contractile function and prevented the increase in iNOS and XO activities and dityrosine level. Cycloheximide 0-2 nitric oxide synthase 2 Rattus norvegicus 86-90 14630716-2 2004 We have previously shown that cytokine-induced iNOS expression is cycloheximide (CHX) sensitive and requires nuclear factor-kappa B (NF-kappa B) activation. Cycloheximide 66-79 nitric oxide synthase 2 Rattus norvegicus 47-51 14630716-2 2004 We have previously shown that cytokine-induced iNOS expression is cycloheximide (CHX) sensitive and requires nuclear factor-kappa B (NF-kappa B) activation. Cycloheximide 81-84 nitric oxide synthase 2 Rattus norvegicus 47-51 10834301-5 2000 Co-treatment of cycloheximide (10(-5) M), a protein synthesis inhibitor, or actinomycin D (10(-7) M), an RNA synthesis inhibitor with LPS inhibited the development of relaxing ability in response to L-arginine, indicating iNOS induction by LPS. Cycloheximide 16-29 nitric oxide synthase 2 Rattus norvegicus 222-226 11385144-9 2001 Using the protein synthesis inhibitor cycloheximide, we demonstrated that meconium directly induced iNOS in macrophages. Cycloheximide 38-51 nitric oxide synthase 2 Rattus norvegicus 100-104 10215633-4 1999 In the RA and CM, functional iNOS induction was blocked by both actinomycin D and cycloheximide; actinomycin D also blocked the appearance of iNOS mRNA in both tissues. Cycloheximide 82-95 nitric oxide synthase 2 Rattus norvegicus 29-33 10215633-5 1999 In contrast, cycloheximide blocked CM (but not RA) iNOS mRNA induction. Cycloheximide 13-26 nitric oxide synthase 2 Rattus norvegicus 51-55 9559891-6 1998 Cycloheximide (1 microM), a protein synthesis inhibitor, prevented iNOS protein expression, nitrite accumulation and the suppression of contractility by IL-1beta on the isolated aortic rings. Cycloheximide 0-13 nitric oxide synthase 2 Rattus norvegicus 67-71 10375811-11 1998 Cycloheximide and dactinomycin also suppressed enhancement of NOS activity stimulated by LPS/dBcAMP, both in nitrite production and citrulline assay, indicating that the enhancement of NOS activity was due to the expression of inducible NOS (iNOS) gene and protein. Cycloheximide 0-13 nitric oxide synthase 2 Rattus norvegicus 227-240 10375811-11 1998 Cycloheximide and dactinomycin also suppressed enhancement of NOS activity stimulated by LPS/dBcAMP, both in nitrite production and citrulline assay, indicating that the enhancement of NOS activity was due to the expression of inducible NOS (iNOS) gene and protein. Cycloheximide 0-13 nitric oxide synthase 2 Rattus norvegicus 242-246 9493500-15 1998 Western blotting using an antibody specific for inducible nitric oxide synthase (NOS) revealed that 17beta-oestradiol (10 micromol/L for 24 h) treatment induced the formation of inducible NOS protein in the aorta, an effect blocked by cycloheximide. Cycloheximide 235-248 nitric oxide synthase 2 Rattus norvegicus 48-79 9878697-4 1999 The enzymatic activity of iNOS was not changed by CsA, since it failed to affect NO production in cells in which iNOS had already been induced with IFN-gamma and any further induction was blocked by protein synthesis inhibitor cycloheximide (CHX). Cycloheximide 227-240 nitric oxide synthase 2 Rattus norvegicus 26-30 9878697-4 1999 The enzymatic activity of iNOS was not changed by CsA, since it failed to affect NO production in cells in which iNOS had already been induced with IFN-gamma and any further induction was blocked by protein synthesis inhibitor cycloheximide (CHX). Cycloheximide 242-245 nitric oxide synthase 2 Rattus norvegicus 26-30 9671378-17 1998 Prior treatment of rats with the protein synthesis inhibitor, cycloheximide, also blunted LPS-induced iNOS mRNA expression. Cycloheximide 62-75 nitric oxide synthase 2 Rattus norvegicus 102-106 9671378-19 1998 LPS-induced iNOS expression is blunted by pretreating rats with dexamethasone or cycloheximide. Cycloheximide 81-94 nitric oxide synthase 2 Rattus norvegicus 12-16 7517798-11 1994 Cycloheximide and actinomycin D completely inhibited the IL-1 beta-induced NOx production and iNOS mRNA expression. Cycloheximide 0-13 nitric oxide synthase 2 Rattus norvegicus 94-98 8879343-9 1996 Thus, IL-1 beta controls iNOS gene expression at the transcriptional level, and an intermediate labile protein, whose synthesis is inhibited by cycloheximide, is required for IL-1 beta stimulated induction of iNOS mRNA transcription in WKY cells but not in SHR. Cycloheximide 144-157 nitric oxide synthase 2 Rattus norvegicus 209-213 8820971-5 1996 The induction of i-NOS by LPS was abolished by cycloheximide, actinomycin D, or dexamethasone. Cycloheximide 47-60 nitric oxide synthase 2 Rattus norvegicus 17-22 7536858-9 1995 Both actinomycin D and cycloheximide significantly inhibited NO synthesis and iNOS mRNA expression. Cycloheximide 23-36 nitric oxide synthase 2 Rattus norvegicus 78-82 8647111-7 1996 Northern blot analysis using rat EC iNOS cDNA as a probe revealed that cycloheximide treatment led to a marked accumulation of iNOS mRNA in the presence and absence of interleukin-1 beta. Cycloheximide 71-84 nitric oxide synthase 2 Rattus norvegicus 36-40 8647111-7 1996 Northern blot analysis using rat EC iNOS cDNA as a probe revealed that cycloheximide treatment led to a marked accumulation of iNOS mRNA in the presence and absence of interleukin-1 beta. Cycloheximide 71-84 nitric oxide synthase 2 Rattus norvegicus 127-131 8603706-3 1996 Even cycloheximide (CHX) added by itself elicited an early, sustained activation of NF-kappa B followed by an intense induction of iNOS gene expression, irrespective of what degree of protein synthesis inhibition was brought about by the several concentrations tested. Cycloheximide 5-18 nitric oxide synthase 2 Rattus norvegicus 131-135 8603706-3 1996 Even cycloheximide (CHX) added by itself elicited an early, sustained activation of NF-kappa B followed by an intense induction of iNOS gene expression, irrespective of what degree of protein synthesis inhibition was brought about by the several concentrations tested. Cycloheximide 20-23 nitric oxide synthase 2 Rattus norvegicus 131-135 8603706-4 1996 When given together, TPA and CHX exerted additive effects on hepatocellular iNOS mRNA levels. Cycloheximide 29-32 nitric oxide synthase 2 Rattus norvegicus 76-80 8603706-5 1996 These results suggest the likelihood of an ordered sequence of events by which an activated NF-kappa B mediates the induction of iNOS gene expression in TPA- and/or CHX-treated primary hepatocytes. Cycloheximide 165-168 nitric oxide synthase 2 Rattus norvegicus 129-133 7524486-4 1994 Cycloheximide, an inhibitor of protein synthesis, prevented IL-1 beta-induced expression of iNOS mRNA, but not MnSOD mRNA. Cycloheximide 0-13 nitric oxide synthase 2 Rattus norvegicus 92-96 7509342-7 1994 Actinomycin D abolished the cAMP-induced iNOS mRNA, whereas cycloheximide remarkably increased iNOS mRNA levels in the presence and absence of 8-bromo-cAMP (superinduction). Cycloheximide 60-73 nitric oxide synthase 2 Rattus norvegicus 95-99 7509342-8 1994 Actinomycin D, but not dexamethasone, completely abolished the cycloheximide-induced iNOS mRNA. Cycloheximide 63-76 nitric oxide synthase 2 Rattus norvegicus 85-89 7508406-4 1994 Cycloheximide potentiated the expression of iNOS mRNA in SMCs in culture stimulated with LPS+IFN gamma but attenuated the response in aortic strips. Cycloheximide 0-13 nitric oxide synthase 2 Rattus norvegicus 44-48 7682068-6 1993 Cycloheximide added along with LPS + IFN gamma totally inhibits iNOS activity, while cycloheximide added 6 h after LPS + IFN gamma did not reduce NO2- and NO3- in tissue culture supernatants. Cycloheximide 0-13 nitric oxide synthase 2 Rattus norvegicus 64-68