PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23006579-2 2012 RT-PCR and cycloheximide inhibition experiments indicated that PMS-induced HIF-1alpha decrease is involved in post-translational degradation during hypoxia. Cycloheximide 11-24 hypoxia inducible factor 1 subunit alpha Homo sapiens 75-85 24436242-8 2015 Furthermore, cycloheximide chase showed that PC7/furin siRNA regulation occurred at the level of HIF-1alpha translation. Cycloheximide 13-26 hypoxia inducible factor 1 subunit alpha Homo sapiens 97-107 24221993-13 2013 HIF-1alpha protein was markedly reduced by resveratrol, and inhibiting HIF-1alpha expression with cycloheximide or specific small interfering RNAs suppressed (18)F-FDG uptake. Cycloheximide 98-111 hypoxia inducible factor 1 subunit alpha Homo sapiens 71-81 26620226-7 2016 This EGF-mediated increase in HIF-1alpha protein was blocked through inhibition of translation by cycloheximide. Cycloheximide 98-111 hypoxia inducible factor 1 subunit alpha Homo sapiens 30-40 23824493-9 2013 Half-life measurements with cycloheximide indicated that S1P treatment stabilized the HIF-1alpha protein. Cycloheximide 28-41 hypoxia inducible factor 1 subunit alpha Homo sapiens 86-96 23088607-5 2012 Estrogen modulation of HIF-1 and subsequent effects on endothelial cells is dependent on the Akt/PI3K pathway and protein synthesis as validated by the use of the inhibitors wortmannin and cycloheximide which abrogated estrogen"s effects respectively. Cycloheximide 189-202 hypoxia inducible factor 1 subunit alpha Homo sapiens 23-28 20713124-3 2010 Treatment with the 26S proteasome inhibitor MG132 failed to abrogate the suppression of HIF-1alpha accumulation induced by IDPm knockdown, whereas HIF-1alpha levels were reduced by cycloheximide treatment in both control and IDPm siRNA-transfected cells. Cycloheximide 181-194 hypoxia inducible factor 1 subunit alpha Homo sapiens 147-157 15930287-8 2005 Instead cycloheximide effectively prevented the increase in HIF-1alpha protein, indicating a stimulatory effect of IL-1beta on HIF-1alpha translation. Cycloheximide 8-21 hypoxia inducible factor 1 subunit alpha Homo sapiens 60-70 18655183-7 2008 Treatment with 100 microM cycloheximide, a protein synthesis inhibitor, replicated the effect of quercetin by inhibiting HIF-1alpha accumulation during hypoxia. Cycloheximide 26-39 hypoxia inducible factor 1 subunit alpha Homo sapiens 121-131 17146432-6 2007 The HIF-1alpha protein level remained up to 60 min in the presence of 6-MP when de novo protein synthesis was blocked by cycloheximide, suggesting that 6-MP induces stabilization of the HIF-1alpha protein. Cycloheximide 121-134 hypoxia inducible factor 1 subunit alpha Homo sapiens 4-14 17122584-9 2006 Cycloheximide, an inhibitor for protein synthesis, completely abrogated the induction of HIF-1alpha protein by isoflurane. Cycloheximide 0-13 hypoxia inducible factor 1 subunit alpha Homo sapiens 89-99 18563715-13 2008 Secondly, cycloheximide, a protein synthesis inhibitor, prevented HIF-1 alpha protein increase in serum-deprived PCa cells. Cycloheximide 10-23 hypoxia inducible factor 1 subunit alpha Homo sapiens 66-77 18381294-6 2008 Using cycloheximide and MG132, we demonstrated that the Cyr61-mediated HIF-1alpha up-regulation was through de novo protein synthesis, rather than increased protein stability. Cycloheximide 6-19 hypoxia inducible factor 1 subunit alpha Homo sapiens 71-81 16051672-10 2005 To examine whether HIF-1alpha is directly induced, we used the translation inhibitor cycloheximide (CHX). Cycloheximide 85-98 hypoxia inducible factor 1 subunit alpha Homo sapiens 19-29 16051672-10 2005 To examine whether HIF-1alpha is directly induced, we used the translation inhibitor cycloheximide (CHX). Cycloheximide 100-103 hypoxia inducible factor 1 subunit alpha Homo sapiens 19-29 15714461-5 2005 In addition, the translation inhibitor cycloheximide confirmed that bFGF-induced HIF-1alpha protein expression was due to de novo protein synthesis. Cycloheximide 39-52 hypoxia inducible factor 1 subunit alpha Homo sapiens 81-91 8674541-2 1996 This complex (HIF-D) resembled mammalian hypoxia inducible factor (HIF-1) in DNA sequence specificity, abrogation of induction by cycloheximide, induction by desferrioxamine and redox sensitivity of DNA binding. Cycloheximide 130-143 hypoxia inducible factor 1 subunit alpha Homo sapiens 67-72 34520103-9 2021 Using a protein synthesis inhibitor, cycloheximide, we also observed that fenofibrate inhibited HIF-1alpha protein synthesis. Cycloheximide 37-50 hypoxia inducible factor 1 subunit alpha Homo sapiens 96-106 11093754-7 2000 The effect of NOC-18 on HIF-1 activity was blocked by cycloheximide, consistent with a post-transcriptional effect. Cycloheximide 54-67 hypoxia inducible factor 1 subunit alpha Homo sapiens 24-29 8408001-3 1993 Induction of HIF-1 is inhibited by cycloheximide, which also inhibits induction of erythropoietin RNA. Cycloheximide 35-48 hypoxia inducible factor 1 subunit alpha Homo sapiens 13-18 35350760-6 2022 The mechanisms of which HNK functions as a direct inhibitor of HIF-1alpha were verified through the ubiquitination assay, the Co-IP assay, and the cycloheximide (CHX) pulse-chase assay. Cycloheximide 147-160 hypoxia inducible factor 1 subunit alpha Homo sapiens 63-73 35350760-6 2022 The mechanisms of which HNK functions as a direct inhibitor of HIF-1alpha were verified through the ubiquitination assay, the Co-IP assay, and the cycloheximide (CHX) pulse-chase assay. Cycloheximide 162-165 hypoxia inducible factor 1 subunit alpha Homo sapiens 63-73