PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35554836-4	2022	STZ-induced diabetes was associated with increased levels of blood glucose, ROS, and IL-6 and decreased levels of IL-2, IL-7, IL-4, and GSH.	Streptozocin	0-3	interleukin 4	Mus musculus	126-130	
33604389-0	2021	Recombinant Lactococcus lactis Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model.	Streptozocin	147-150	interleukin 4	Mus musculus	40-44	
33604389-3	2021	Therefore, the aim of this study was to investigate the effect of orally administered Lactococcus lactis MG1363 FnBPA+ strains carrying plasmids encoding IL-4 and IL-10 in the streptozotocin- (STZ-) induced diabetes model and in nonobese diabetic (NOD) mice.	Streptozocin	176-190	interleukin 4	Mus musculus	154-158	
33604389-3	2021	Therefore, the aim of this study was to investigate the effect of orally administered Lactococcus lactis MG1363 FnBPA+ strains carrying plasmids encoding IL-4 and IL-10 in the streptozotocin- (STZ-) induced diabetes model and in nonobese diabetic (NOD) mice.	Streptozocin	193-196	interleukin 4	Mus musculus	154-158	
33604389-4	2021	The STZ-induced mice that were treated with combined bacterial strains carrying plasmids encoding IL-4 and IL-10 showed lower incidence of diabetes and more preserved pancreatic islets than the mice that received the individual bacterial strains.	Streptozocin	4-7	interleukin 4	Mus musculus	98-102	
18064633-7	2008	These data, along with the higher expression of IL-4 and TGF-beta observed in the periphery and in the pancreas of MLD-STZ-challenged MIF(-/-) mice as compared to WT controls suggest that MIF deficiency has induced an immune deviation towards protective type 2/3 response.	Streptozocin	119-122	interleukin 4	Mus musculus	48-52	
11999343-6	2002	In islets of C57BL/6 mice of both genders MLD-STZ similarly stimulated production of IFN-gamma and TNF-alpha, but significantly reduced IL-4 and IL-10 levels in male mice only.	Streptozocin	46-49	interleukin 4	Mus musculus	136-140	
11999343-8	2002	Here, MLD-STZ markedly decreased the levels of IFN-gamma and TNF-alpha, but significantly increased the levels of IL-4 and IL-10.	Streptozocin	10-13	interleukin 4	Mus musculus	114-118	
10066341-0	1999	Multidose streptozotocin induction of diabetes in BALB/cBy mice induces a T cell proliferation defect in thymocytes which is reversible by interleukin-4.	Streptozocin	10-24	interleukin 4	Mus musculus	139-152	
10066341-4	1999	RT-PCR analysis of thymocyte RNA revealed that levels of IL-4 mRNA were dramatically decreased in STZ-treated mice.	Streptozocin	98-101	interleukin 4	Mus musculus	57-61	
10066341-5	1999	Levels of mRNA encoding IFN-gamma were similar, but the appearance was delayed in thymocytes derived from STZ-treated mice, implying differential regulation of IL-4 and IFN-gamma.	Streptozocin	106-109	interleukin 4	Mus musculus	160-164	
10066341-6	1999	Defective thymocyte proliferation was partially restored by exposure to IL-2 in vitro; however, IL-4 completely reversed the STZ-induced defect.	Streptozocin	125-128	interleukin 4	Mus musculus	96-100	
10066341-7	1999	Administration in vivo of IL-4 before STZ treatment reversed the STZ-induced thymocyte proliferation defect and prevented both pancreatic islet destruction and hyperglycemia.	Streptozocin	65-68	interleukin 4	Mus musculus	26-30	
10066341-9	1999	Collectively these experiments suggest that STZ treatment of mice reduces expression of IL-4 which is associated with development of autoimmune diabetes.	Streptozocin	44-47	interleukin 4	Mus musculus	88-92	
28142150-5	2017	RESULTS: Induction of diabetes by streptozotocin was associated with reduction of body weight and insulin level, increase in glucose level and pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha), and reduction in IL-2 and IL-4 levels.	Streptozocin	34-48	interleukin 4	Mus musculus	229-233	
27050967-0	2016	All-trans retinoic acid prevents the development of type 1 diabetes by affecting the levels of interferon gamma and interleukin 4 in streptozotocin-induced murine diabetes model.	Streptozocin	133-147	interleukin 4	Mus musculus	116-129	
27050967-6	2016	Meanwhile, ATRA was shown to decrease the levels of IFN-gamma and increase the levels of IL-4 as well as the IFN-gamma/IL-4 ratio in STZ-treated animals (P < 0.05).	Streptozocin	133-136	interleukin 4	Mus musculus	119-123	
8617981-6	1996	We have found that IL-2, IL-4, TNF-alpha, and IFN-gamma are expressed by the time the fourth dose of STZ is given.	Streptozocin	101-104	interleukin 4	Mus musculus	25-29	
8617981-10	1996	Cells in the pancreases of nondiabetic mice treated with anti-IFN-gamma mAb and STZ show enhanced expression of IL-4, but the prevention of disease is due to blockade of the IFN-gamma itself, and not due to secretion of IL-4, because systemic administration of IL-4 does not prevent MDSDM.	Streptozocin	80-83	interleukin 4	Mus musculus	112-116	
8617981-10	1996	Cells in the pancreases of nondiabetic mice treated with anti-IFN-gamma mAb and STZ show enhanced expression of IL-4, but the prevention of disease is due to blockade of the IFN-gamma itself, and not due to secretion of IL-4, because systemic administration of IL-4 does not prevent MDSDM.	Streptozocin	80-83	interleukin 4	Mus musculus	220-224	
8617981-10	1996	Cells in the pancreases of nondiabetic mice treated with anti-IFN-gamma mAb and STZ show enhanced expression of IL-4, but the prevention of disease is due to blockade of the IFN-gamma itself, and not due to secretion of IL-4, because systemic administration of IL-4 does not prevent MDSDM.	Streptozocin	80-83	interleukin 4	Mus musculus	220-224